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AR057324A1 - Tigeciclina y metodos para preparar 9-aminominociclina - Google Patents

Tigeciclina y metodos para preparar 9-aminominociclina

Info

Publication number
AR057324A1
AR057324A1 ARP060102153A ARP060102153A AR057324A1 AR 057324 A1 AR057324 A1 AR 057324A1 AR P060102153 A ARP060102153 A AR P060102153A AR P060102153 A ARP060102153 A AR P060102153A AR 057324 A1 AR057324 A1 AR 057324A1
Authority
AR
Argentina
Prior art keywords
methods
tigecicline
aminominocicline
prepare
salts
Prior art date
Application number
ARP060102153A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR057324A1 publication Critical patent/AR057324A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se revelan métodos para preparar y purificar tetraciclinas, tales como tigeciclina. También se revelan composiciones de tetraciclinas, tales como composiciones de tigeciclina, preparadas por estos métodos. Reivindicacion 1: Un método para preparar, al menos, un compuesto de formula (1), o una de sus sales, donde R = -NR3R4, donde R3 y R4 se seleccionan, cada uno en forma independiente, de hidrogeno y alquilo C1-4 de cadena lineal y ramificada, que comprende: combinar, al menos, un agente reductor con una mezcla de reaccion en suspension que comprende un intermediario preparado a partir de una reaccion entre, al menos, un agente, nitrante y, al menos, un compuesto de formula (2), o una de sus sales.
ARP060102153A 2005-05-27 2006-05-24 Tigeciclina y metodos para preparar 9-aminominociclina AR057324A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68514605P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
AR057324A1 true AR057324A1 (es) 2007-11-28

Family

ID=37025920

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102153A AR057324A1 (es) 2005-05-27 2006-05-24 Tigeciclina y metodos para preparar 9-aminominociclina

Country Status (21)

Country Link
US (1) US20070049563A1 (es)
EP (1) EP1885686A2 (es)
JP (1) JP2008545707A (es)
KR (1) KR20080016894A (es)
CN (1) CN101228113A (es)
AR (1) AR057324A1 (es)
AU (1) AU2006252686A1 (es)
BR (1) BRPI0610649A2 (es)
CA (1) CA2609649A1 (es)
CR (1) CR9538A (es)
EC (1) ECSP078056A (es)
GT (1) GT200600222A (es)
IL (1) IL187358A0 (es)
MX (1) MX2007014734A (es)
NI (1) NI200700300A (es)
NO (1) NO20075998L (es)
PE (1) PE20061447A1 (es)
RU (1) RU2007143159A (es)
TW (1) TW200716515A (es)
WO (1) WO2006130500A2 (es)
ZA (1) ZA200710154B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US7871993B2 (en) * 2006-04-24 2011-01-18 Teva Pharmaceutical Industries Ltd. Tigecycline crystalline forms and processes for preparation thereof
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
WO2008066935A2 (en) * 2006-11-29 2008-06-05 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
US20090099376A1 (en) * 2007-10-16 2009-04-16 Wyeth Tigecycline and methods of preparing intermediates
SI2220033T1 (sl) * 2007-11-14 2015-07-31 Sandoz Ag Kristalna oblika tigeciklin hidroklorida
CA2746585C (en) 2008-12-18 2017-08-29 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
CA2751238A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
IT1393350B1 (it) * 2009-03-16 2012-04-20 Antibioticos Spa Processo di preparazione di tigeciclina
EP2327676B1 (en) * 2009-11-26 2014-03-05 Sandoz Ag Reaction of organic compounds with low amounts of hydrogen
CN101919816B (zh) * 2010-07-02 2012-07-25 赵军旭 一种含有替加环素的注射用无菌分装制剂
CN101973906B (zh) * 2010-09-27 2014-03-19 重庆福安药业(集团)股份有限公司 一种替加环素无定形态的制备方法
CN101955443B (zh) * 2010-09-30 2012-05-23 浙江大学 一种替加环素中间体及其盐的制备方法
CN102617395B (zh) * 2011-01-29 2014-06-11 正大天晴药业集团股份有限公司 一种甘氨酰环素类抗生素的制备方法
CN103044280B (zh) * 2012-12-20 2015-04-22 安徽悦康凯悦制药有限公司 替加环素的制备方法
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
CN111855857B (zh) * 2020-07-30 2022-07-26 武汉药品医疗器械检验所 一种盐酸米诺环素及其杂质的高效液相色谱检测方法

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) * 1967-09-26 Reductive alkylation process
US3026248A (en) * 1959-09-11 1962-03-20 Pfizer & Co C Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (es) * 1960-05-23 1966-05-25
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
US3502696A (en) * 1961-08-18 1970-03-24 Pfizer & Co C Antibacterial agents
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3250810A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-hydroxy-6-halomethyl tetracyclines
US3145228A (en) * 1962-09-06 1964-08-18 Pfizer & Co C 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof
US3250809A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives
US3219529A (en) * 1962-10-04 1965-11-23 American Cyanamid Co Stable tetracycline solutions
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3433834A (en) * 1966-03-14 1969-03-18 American Cyanamid Co Nitration of 11a-chloro tetracyclines
US3397230A (en) * 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
US3341585A (en) * 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3849493A (en) * 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3345410A (en) * 1966-12-01 1967-10-03 American Cyanamid Co Substituted 7- and/or 9-amino tetracyclines
US3373196A (en) * 1967-03-21 1968-03-12 American Cyanamid Co 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines
US3373197A (en) * 1967-04-27 1968-03-12 American Cyanamid Co Substituted 6-epitetracyclines and 5a-epi-6-epitetracyclines
US3373198A (en) * 1967-04-27 1968-03-12 American Cyanamid Co Substituted 5a, 11a-dehydro-6-epitetracyclines
US3360561A (en) * 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
JPS5697277A (en) * 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5843925A (en) * 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US6946453B2 (en) * 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
US6833365B2 (en) * 2000-01-24 2004-12-21 Trustees Of Tufts College Tetracycline compounds for treatment of Cryptosporidium parvum related disorders
WO2001074761A1 (en) * 2000-03-31 2001-10-11 Trustees Of Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
EA009175B1 (ru) * 2000-07-07 2007-12-28 Трастис Оф Тафтс Коллидж Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
EP1303479B1 (en) * 2000-07-07 2011-04-06 Trustees Of Tufts College 7-, 8- and 9-substituted tetracycline compounds
JP2005505588A (ja) * 2001-10-05 2005-02-24 テトラジェネックス ファーマスーティカルズ インク テトラサイクリン誘導体、及びそれを使用する方法
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina

Also Published As

Publication number Publication date
GT200600222A (es) 2007-01-12
CR9538A (es) 2008-02-20
CN101228113A (zh) 2008-07-23
ZA200710154B (en) 2009-05-27
NO20075998L (no) 2008-02-19
WO2006130500A8 (en) 2008-01-10
PE20061447A1 (es) 2007-01-22
WO2006130500A2 (en) 2006-12-07
WO2006130500A3 (en) 2007-01-18
BRPI0610649A2 (pt) 2010-07-13
US20070049563A1 (en) 2007-03-01
ECSP078056A (es) 2008-01-23
IL187358A0 (en) 2008-04-13
TW200716515A (en) 2007-05-01
AU2006252686A1 (en) 2006-12-07
EP1885686A2 (en) 2008-02-13
JP2008545707A (ja) 2008-12-18
CA2609649A1 (en) 2006-12-07
RU2007143159A (ru) 2009-07-10
NI200700300A (es) 2008-07-03
MX2007014734A (es) 2008-02-15
KR20080016894A (ko) 2008-02-22

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