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AR057033A1 - Tigeciclina y metodos para preparar 9-nitrominociclina - Google Patents

Tigeciclina y metodos para preparar 9-nitrominociclina

Info

Publication number
AR057033A1
AR057033A1 ARP060102155A ARP060102155A AR057033A1 AR 057033 A1 AR057033 A1 AR 057033A1 AR P060102155 A ARP060102155 A AR P060102155A AR P060102155 A ARP060102155 A AR P060102155A AR 057033 A1 AR057033 A1 AR 057033A1
Authority
AR
Argentina
Prior art keywords
methods
compound
formula
tigecicline
nitrominocicline
Prior art date
Application number
ARP060102155A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR057033A1 publication Critical patent/AR057033A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se revelan métodos para preparar y purificar tetraciclinas, tales como tigeciclina. Tales se revelan composiciones de tetraciclinas, tales como composiciones de tigeciclina, preparadas por estos métodos. Reivindicacion 1: Un método para preparar al menos un compuesto de formula (1), o una sal aceptable para uso farmacéutico del mismo, donde R1 y R2 se selecciona cada uno en forma independiente de hidrogeno, alquilo (C1-6) de cadena recta y ramificada y cicloalquilo, o R1 y R2, junto con N, forman un heterociclo; R es -NR3R4, donde R3 y R4 se selecciona cada uno en forma independiente de hidrogeno, y alquilo (C1-6) de cadena recta y ramificada; y n oscila entre 1-4, que comprende: (a) hacer reaccionar al menos un agente nitrante con al menos un compuesto de formula (2), o una sal del mismo, para producir una mezcla de reaccion que comprende un intermediario; y (b) hacer además reaccionar el intermediario para formar el al menos un compuesto de formula 1, donde el intermediario no se aísla de la mezcla de reaccion.
ARP060102155A 2005-05-27 2006-05-24 Tigeciclina y metodos para preparar 9-nitrominociclina AR057033A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68529105P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
AR057033A1 true AR057033A1 (es) 2007-11-14

Family

ID=36933528

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102155A AR057033A1 (es) 2005-05-27 2006-05-24 Tigeciclina y metodos para preparar 9-nitrominociclina

Country Status (20)

Country Link
US (1) US20070049560A1 (es)
EP (1) EP1885687A2 (es)
JP (1) JP2008545708A (es)
KR (1) KR20080016893A (es)
CN (1) CN101228111A (es)
AR (1) AR057033A1 (es)
AU (1) AU2006252687A1 (es)
BR (1) BRPI0610268A2 (es)
CA (1) CA2609264A1 (es)
CR (1) CR9543A (es)
EC (1) ECSP078042A (es)
GT (1) GT200600223A (es)
IL (1) IL187539A0 (es)
MX (1) MX2007014718A (es)
NO (1) NO20076072L (es)
PE (1) PE20061422A1 (es)
RU (1) RU2007143164A (es)
TW (1) TW200716514A (es)
WO (1) WO2006130501A2 (es)
ZA (1) ZA200710173B (es)

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AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US7871993B2 (en) * 2006-04-24 2011-01-18 Teva Pharmaceutical Industries Ltd. Tigecycline crystalline forms and processes for preparation thereof
US8198470B2 (en) 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
WO2008066935A2 (en) 2006-11-29 2008-06-05 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
US20090099376A1 (en) * 2007-10-16 2009-04-16 Wyeth Tigecycline and methods of preparing intermediates
SI2220033T1 (sl) * 2007-11-14 2015-07-31 Sandoz Ag Kristalna oblika tigeciklin hidroklorida
CA2746585C (en) 2008-12-18 2017-08-29 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
CA2751238A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
EP2327676B1 (en) * 2009-11-26 2014-03-05 Sandoz Ag Reaction of organic compounds with low amounts of hydrogen
CA2799079C (en) 2010-05-12 2019-01-15 Rempex Pharmaceuticals, Inc. Tetracycline compositions
CN102391148B (zh) * 2011-10-24 2014-01-08 江苏奥赛康药业股份有限公司 一种高纯度替加环素的合成方法
CN103044281A (zh) * 2013-01-02 2013-04-17 湖南赛隆药业有限公司 高纯度替加环素的制法
CN104418766B (zh) * 2013-08-26 2018-09-07 江苏豪森药业集团有限公司 替加环素的纯化方法
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
CN104211617A (zh) * 2014-08-29 2014-12-17 重庆康乐制药有限公司 一种替加环素的制备方法
CN111362829B (zh) * 2018-12-26 2021-11-30 浙江昌海制药有限公司 一种米诺环素二对氯苯磺酸盐晶型及其制备方法和应用
CN111060641B (zh) * 2019-12-27 2020-10-23 瀚晖制药有限公司 一种注射用替加环素中9-硝基米诺环素的检测方法
WO2022029796A1 (en) * 2020-08-04 2022-02-10 Sumar Biotech Llp An improved process for the preparation of Tigecycline intermediate and process for the preparation of Tigecycline therefrom
CN114957031B (zh) * 2022-05-17 2024-05-31 河北圣雪大成制药有限责任公司 一种合成9-氨基米诺环素硫酸盐的新方法

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Also Published As

Publication number Publication date
US20070049560A1 (en) 2007-03-01
TW200716514A (en) 2007-05-01
ECSP078042A (es) 2008-01-23
GT200600223A (es) 2007-05-08
EP1885687A2 (en) 2008-02-13
CR9543A (es) 2008-02-20
NO20076072L (no) 2008-02-19
KR20080016893A (ko) 2008-02-22
ZA200710173B (en) 2009-09-30
WO2006130501A3 (en) 2007-03-29
AU2006252687A1 (en) 2006-12-07
IL187539A0 (en) 2008-03-20
MX2007014718A (es) 2008-02-15
CN101228111A (zh) 2008-07-23
RU2007143164A (ru) 2009-07-10
CA2609264A1 (en) 2006-12-07
WO2006130501A2 (en) 2006-12-07
JP2008545708A (ja) 2008-12-18
PE20061422A1 (es) 2007-01-29
BRPI0610268A2 (pt) 2010-06-08

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