ATE444290T1 - Oxazolderivate von tetracyclinen - Google Patents

Oxazolderivate von tetracyclinen

Info

Publication number: ATE444290T1
Authority: AT; Austria
Prior art keywords: tetracyclines; oxazole derivatives; oxazole; derivatives
Prior art date: 2003-12-08

Application number

AT04813199T

Other languages

English (en)

Inventor

Phaik-Eng Sum

David How

Darrin Hopper

Matthew Vera

Joshua Sabatini

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-08

Filing date

2004-12-07

Publication date

2009-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34681543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE444290(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-12-07 Application filed by Wyeth Corp filed Critical Wyeth Corp

2009-10-15 Application granted granted Critical

2009-10-15 Publication of ATE444290T1 publication Critical patent/ATE444290T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT04813199T 2003-12-08 2004-12-07 Oxazolderivate von tetracyclinen ATE444290T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US52792803P	2003-12-08	2003-12-08
US58482304P	2004-07-01	2004-07-01
PCT/US2004/040850 WO2005056538A1 (en)	2003-12-08	2004-12-07	Oxazole derivatives of tetracyclines

Publications (1)

Publication Number	Publication Date
ATE444290T1 true ATE444290T1 (de)	2009-10-15

Family

ID=34681543

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04813199T ATE444290T1 (de)	2003-12-08	2004-12-07	Oxazolderivate von tetracyclinen
AT09010915T ATE525365T1 (de)	2003-12-08	2004-12-07	Oxazol, derivate aus tetracyclinen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT09010915T ATE525365T1 (de)	2003-12-08	2004-12-07	Oxazol, derivate aus tetracyclinen

Country Status (25)

Country	Link
US (3)	US7176225B2 (de)
EP (2)	EP1692117B1 (de)
JP (1)	JP4848287B2 (de)
KR (1)	KR101164262B1 (de)
CN (1)	CN100545151C (de)
AR (1)	AR047274A1 (de)
AT (2)	ATE444290T1 (de)
AU (1)	AU2004297243B2 (de)
BR (1)	BRPI0417421A (de)
CA (1)	CA2546895A1 (de)
CO (1)	CO5700818A2 (de)
CR (1)	CR8437A (de)
DE (1)	DE602004023417D1 (de)
EC (1)	ECSP066605A (de)
ES (2)	ES2372635T3 (de)
IL (2)	IL176162A (de)
MY (1)	MY146098A (de)
NO (1)	NO20062629L (de)
PA (1)	PA8619601A1 (de)
PE (1)	PE20050995A1 (de)
RU (1)	RU2415844C2 (de)
SG (1)	SG148216A1 (de)
TW (1)	TW200528437A (de)
UA (2)	UA83266C2 (de)
WO (1)	WO2005056538A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101171408B1 (ko)	2004-05-21	2012-08-08	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	테트라사이클린 및 이의 유사체의 합성
US7858601B2 (en)	2004-10-25	2010-12-28	Paratek Pharmaceuticals, Inc.	4-substituted tetracyclines and methods of use thereof
AR057032A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos de preparacion
AR057324A1 (es) *	2005-05-27	2007-11-28	Wyeth Corp	Tigeciclina y metodos para preparar 9-aminominociclina
AR057033A1 (es) *	2005-05-27	2007-11-14	Wyeth Corp	Tigeciclina y metodos para preparar 9-nitrominociclina
AU2006272698B2 (en) *	2005-07-21	2012-11-01	Paratek Pharmaceuticals, Inc.	10-substituted tetracyclines and methods of use thereof
US8486921B2 (en)	2006-04-07	2013-07-16	President And Fellows Of Harvard College	Synthesis of tetracyclines and analogues thereof
US8440646B1 (en)	2006-10-11	2013-05-14	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for treatment of Bacillus anthracis infections
WO2008127361A2 (en)	2006-10-11	2008-10-23	President And Fellows Of Harvard College	Synthesis of enone intermediate
US8121767B2 (en) *	2007-11-02	2012-02-21	GM Global Technology Operations LLC	Predicted and immediate output torque control architecture for a hybrid powertrain system
EP2220033B1 (de) *	2007-11-14	2014-12-17	Sandoz AG	Kristalline formen von tigecyclinhydrochlorid
JP2011527708A (ja)	2008-07-11	2011-11-04	ニュメディックス	減少した抗菌活性および神経保護作用の利点を有するテトラサイクリン誘導体
US8513224B2 (en)	2008-12-18	2013-08-20	Sandoz Ag	Crystalline form C of tigecycline dihydrochloride and methods for its preparation
US9073829B2 (en)	2009-04-30	2015-07-07	President And Fellows Of Harvard College	Synthesis of tetracyclines and intermediates thereto

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US26253A (en) *		1859-11-29		Vegetable-cutter
US2482055A (en)	1948-02-11	1949-09-13	American Cyanamid Co	Aureomycin and preparation of same
US3007965A (en)	1959-02-13	1961-11-07	American Cyanamid Co	New tetracyclines produced by streptomyces aureofaciens
US3043875A (en)	1959-10-22	1962-07-10	Pfizer & Co C	Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (de)	1960-05-23	1966-05-25
US3338963A (en)	1960-10-28	1967-08-29	American Cyanamid Co	Tetracycline compounds
US3148212A (en)	1961-12-22	1964-09-08	American Cyanamid Co	Reductive alkylation process
US3360557A (en)	1963-05-10	1967-12-26	American Cyanamid Co	9-hydroxytetracyclines and a process of preparing same
USRE26253E (en)	1963-05-17	1967-08-15		And z-alkylamino-g-deoxytetracycline
US3341585A (en)	1966-05-06	1967-09-12	American Cyanamid Co	Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3360561A (en)	1967-06-19	1967-12-26	American Cyanamid Co	Nitration of tetracyclines
US3518306A (en)	1968-02-19	1970-06-30	American Cyanamid Co	7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US4806529A (en)	1982-11-18	1989-02-21	Trustees Of Tufts College, Tufts University	Tetracycline activity enhancement
US5494903A (en)	1991-10-04	1996-02-27	American Cyanamid Company	7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DE122006000058I1 (de) *	1991-10-04	2007-01-18	Wyeth Corp	7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5328902A (en) *	1992-08-13	1994-07-12	American Cyanamid Co.	7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
CO5190716A1 (es) *	1999-08-10	2002-08-29	Smithkline Beecham Corp	4,4-diaril-ciclohexanos 1,4-sustituidos
WO2003005971A2 (en) *	2001-07-13	2003-01-23	Paratek Pharmaceuticals, Inc.	Tetracycline compounds having target therapeutic activities

2004
- 2004-07-12 UA UAA200606344A patent/UA83266C2/ru unknown
- 2004-10-30 UA UAA200606646A patent/UA83268C2/ru unknown
- 2004-12-01 TW TW093137032A patent/TW200528437A/zh unknown
- 2004-12-07 JP JP2006542866A patent/JP4848287B2/ja not_active Expired - Fee Related
- 2004-12-07 ES ES09010915T patent/ES2372635T3/es not_active Expired - Lifetime
- 2004-12-07 RU RU2006118367/04A patent/RU2415844C2/ru not_active IP Right Cessation
- 2004-12-07 CA CA002546895A patent/CA2546895A1/en not_active Abandoned
- 2004-12-07 PE PE2004001203A patent/PE20050995A1/es not_active Application Discontinuation
- 2004-12-07 AR ARP040104570A patent/AR047274A1/es unknown
- 2004-12-07 EP EP04813199A patent/EP1692117B1/de not_active Expired - Lifetime
- 2004-12-07 AT AT04813199T patent/ATE444290T1/de not_active IP Right Cessation
- 2004-12-07 AU AU2004297243A patent/AU2004297243B2/en not_active Ceased
- 2004-12-07 MY MYPI20045049A patent/MY146098A/en unknown
- 2004-12-07 BR BRPI0417421-6A patent/BRPI0417421A/pt not_active IP Right Cessation
- 2004-12-07 DE DE602004023417T patent/DE602004023417D1/de not_active Expired - Lifetime
- 2004-12-07 AT AT09010915T patent/ATE525365T1/de not_active IP Right Cessation
- 2004-12-07 SG SG200809014-4A patent/SG148216A1/en unknown
- 2004-12-07 WO PCT/US2004/040850 patent/WO2005056538A1/en active Application Filing
- 2004-12-07 ES ES04813199T patent/ES2331574T3/es not_active Expired - Lifetime
- 2004-12-07 KR KR1020067013606A patent/KR101164262B1/ko not_active IP Right Cessation
- 2004-12-07 EP EP09010915A patent/EP2157085B1/de not_active Expired - Lifetime
- 2004-12-07 CN CNB2004800364939A patent/CN100545151C/zh not_active Expired - Fee Related
- 2004-12-07 PA PA20048619601A patent/PA8619601A1/es unknown
- 2004-12-08 US US11/007,621 patent/US7176225B2/en not_active Expired - Fee Related
2006
- 2006-06-05 EC EC2006006605A patent/ECSP066605A/es unknown
- 2006-06-06 CR CR8437A patent/CR8437A/es not_active Application Discontinuation
- 2006-06-06 IL IL176162A patent/IL176162A/en not_active IP Right Cessation
- 2006-06-08 NO NO20062629A patent/NO20062629L/no not_active Application Discontinuation
- 2006-06-08 CO CO06055450A patent/CO5700818A2/es unknown
- 2006-12-13 US US11/638,138 patent/US7365087B2/en not_active Expired - Fee Related
2008
- 2008-03-24 US US12/053,856 patent/US20080177080A1/en not_active Abandoned
2010
- 2010-05-27 IL IL206050A patent/IL206050A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PA8619601A1 (es)	2006-03-24
CO5700818A2 (es)	2006-11-30
CN100545151C (zh)	2009-09-30
US7176225B2 (en)	2007-02-13
EP1692117B1 (de)	2009-09-30
IL206050A0 (en)	2010-11-30
MY146098A (en)	2012-06-29
TW200528437A (en)	2005-09-01
CR8437A (es)	2006-10-06
IL206050A (en)	2013-01-31
CA2546895A1 (en)	2005-06-23
KR101164262B1 (ko)	2012-07-09
IL176162A0 (en)	2006-10-05
KR20060105047A (ko)	2006-10-09
EP1692117A1 (de)	2006-08-23
ECSP066605A (es)	2006-10-25
RU2006118367A (ru)	2008-01-20
ES2331574T3 (es)	2010-01-08
UA83268C2 (en)	2008-06-25
JP2007515411A (ja)	2007-06-14
PE20050995A1 (es)	2006-01-11
JP4848287B2 (ja)	2011-12-28
SG148216A1 (en)	2008-12-31
AU2004297243A1 (en)	2005-06-23
RU2415844C2 (ru)	2011-04-10
US20050153944A1 (en)	2005-07-14
AR047274A1 (es)	2006-01-11
US7365087B2 (en)	2008-04-29
US20080064667A1 (en)	2008-03-13
DE602004023417D1 (de)	2009-11-12
WO2005056538A1 (en)	2005-06-23
EP2157085A1 (de)	2010-02-24
EP2157085B1 (de)	2011-09-21
US20080177080A1 (en)	2008-07-24
BRPI0417421A (pt)	2007-03-13
ATE525365T1 (de)	2011-10-15
UA83266C2 (en)	2008-06-25
IL176162A (en)	2011-09-27
NO20062629L (no)	2006-09-06
CN1890226A (zh)	2007-01-03
AU2004297243B2 (en)	2011-02-17
ES2372635T3 (es)	2012-01-25

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ATE423771T1 (de)	2009-03-15	Tetrahydrochinolinderivate
DE602004026773D1 (de)	2010-06-02	Verfahrensherstellung von ethern
DE60212694D1 (de)	2006-08-03	Benzothiazolderivaten
DE50306277D1 (de)	2007-02-22	4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate
DE602004030779D1 (de)	2011-02-10	Angehen des problems des schrittmachersyndroms
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ATE499348T1 (de)	2011-03-15	Stabiler polymorph von bifeprunoxmesilat
DE60305741D1 (de)	2006-07-06	Neue halbsynthetische macrolidantibiotika der azalidreihe
DE60323088D1 (de)	2008-10-02	Leberschützende wirkung der 10-o-p-hydroxybenzoylaucubin
ATE410417T1 (de)	2008-10-15	Kristallmodifikationen von triazinylaminostilbenen

Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties