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SV1998000065A - Formulas estables de insulina ref. x-10675 - Google Patents

Formulas estables de insulina ref. x-10675

Info

Publication number
SV1998000065A
SV1998000065A SV1998000065A SV1998000065A SV1998000065A SV 1998000065 A SV1998000065 A SV 1998000065A SV 1998000065 A SV1998000065 A SV 1998000065A SV 1998000065 A SV1998000065 A SV 1998000065A SV 1998000065 A SV1998000065 A SV 1998000065A
Authority
SV
El Salvador
Prior art keywords
insulin
human
lys
group
ref
Prior art date
Application number
SV1998000065A
Other languages
English (en)
Inventor
Michael Rosario Defelippis
Dobbins Michael Allen
Frank Bruce Hill
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV1998000065A publication Critical patent/SV1998000065A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UNA SOLUCION QUE INCLUYE UN BUFER FISIOLOGICAMENTE TOLERADO SELECCIONADO DEL GRUPO QUE CONSISTE DE TRIS Y L-ARGININA; Y UN COMPLEJO HEXAMERO ANALOGO DE INSULINA QUE INCLUYE; A) 6 MOLECULAS DE UN ANALOGO DE INSULINA HUMANA, DONDE EL ANALOGO DE INSULINA HUMANA SE SELECCIONA DEL GRUPO QUE CONSISTE DE : i) INSULINA HUMANA DONDE PRO EN LA POSICION B28 SE SUSTITUYE CON ASP, LYS, LEU, VAL, ALA Y LYS EN AL POSICION B29 ES LYS O PRO; ii) INSULINA ALA B26-HUMANA; iii) INSULINA DES(B28-B30); iv) INSULINA DES(B27)-HUMANA; B) DOS IONES DE ZINC; C) POR LO MENOS TRES MOLECULAS DE UN PRESERVANTE FENOLICO SELECCIONADO DEL GRUPO QUE CONSISTE DE: i) CLOROCRESOL; ii) M-CRESOL; iii) FENOL; iv)MEZCLAS DE CLOROCRESOL, M-CRESOL Y FENOL.
SV1998000065A 1997-06-13 1998-06-08 Formulas estables de insulina ref. x-10675 SV1998000065A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5308997P 1997-06-13 1997-06-13

Publications (1)

Publication Number Publication Date
SV1998000065A true SV1998000065A (es) 1999-02-03

Family

ID=21981869

Family Applications (1)

Application Number Title Priority Date Filing Date
SV1998000065A SV1998000065A (es) 1997-06-13 1998-06-08 Formulas estables de insulina ref. x-10675

Country Status (31)

Country Link
US (3) US6034054A (es)
EP (1) EP0884053B1 (es)
JP (1) JP2002504908A (es)
KR (1) KR100597500B1 (es)
CN (1) CN1293916C (es)
AR (1) AR012894A1 (es)
AT (2) ATE226088T1 (es)
AU (1) AU734781B2 (es)
BR (1) BR9810116B1 (es)
CA (1) CA2295140C (es)
CO (1) CO4750643A1 (es)
CZ (1) CZ299637B6 (es)
DE (2) DE69808695T2 (es)
DK (1) DK0884053T3 (es)
EA (1) EA002880B1 (es)
ES (2) ES2264713T3 (es)
HK (1) HK1030747A1 (es)
HU (1) HUP0002877A3 (es)
ID (1) ID24310A (es)
IL (1) IL133348A0 (es)
NO (1) NO996131L (es)
NZ (1) NZ501382A (es)
PE (1) PE79099A1 (es)
PL (1) PL194244B1 (es)
PT (2) PT884053E (es)
SV (1) SV1998000065A (es)
TR (1) TR199903036T2 (es)
TW (1) TW577753B (es)
UA (1) UA61109C2 (es)
WO (1) WO1998056406A1 (es)
ZA (1) ZA984697B (es)

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