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SMT202400233T1 - Modulatori di enzimi modificanti il metile, composizioni e usi degli stessi - Google Patents

Modulatori di enzimi modificanti il metile, composizioni e usi degli stessi

Info

Publication number
SMT202400233T1
SMT202400233T1 SM20240233T SMT202400233T SMT202400233T1 SM T202400233 T1 SMT202400233 T1 SM T202400233T1 SM 20240233 T SM20240233 T SM 20240233T SM T202400233 T SMT202400233 T SM T202400233T SM T202400233 T1 SMT202400233 T1 SM T202400233T1
Authority
SM
San Marino
Prior art keywords
modulators
compositions
modifying enzymes
methyl modifying
methyl
Prior art date
Application number
SM20240233T
Other languages
English (en)
Inventor
Victor S Gehling
Avinash Khanna
Alexandre Côté
Ludivine Moine
Jacob I Stuckey
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of SMT202400233T1 publication Critical patent/SMT202400233T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
SM20240233T 2018-04-18 2019-04-17 Modulatori di enzimi modificanti il metile, composizioni e usi degli stessi SMT202400233T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862659408P 2018-04-18 2018-04-18
EP19722363.9A EP3781561B1 (en) 2018-04-18 2019-04-17 Modulators of methyl modifying enzymes, compositions and uses thereof
PCT/US2019/027932 WO2019204490A1 (en) 2018-04-18 2019-04-17 Modulators of methyl modifying enzymes, compositions and uses thereof

Publications (1)

Publication Number Publication Date
SMT202400233T1 true SMT202400233T1 (it) 2024-07-09

Family

ID=66429588

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20240233T SMT202400233T1 (it) 2018-04-18 2019-04-17 Modulatori di enzimi modificanti il metile, composizioni e usi degli stessi

Country Status (34)

Country Link
US (3) US10689371B2 (it)
EP (2) EP4421072A1 (it)
JP (2) JP7256823B2 (it)
KR (2) KR102798145B1 (it)
CN (2) CN119954787A (it)
AR (1) AR114793A1 (it)
AU (1) AU2019255310B2 (it)
BR (1) BR112020021194A2 (it)
CA (1) CA3098428A1 (it)
CL (1) CL2020002698A1 (it)
CO (1) CO2020014217A2 (it)
CR (1) CR20200553A (it)
DK (1) DK3781561T3 (it)
EA (1) EA202092490A1 (it)
ES (1) ES2983344T3 (it)
FI (1) FI3781561T3 (it)
HR (1) HRP20240793T1 (it)
HU (1) HUE066783T2 (it)
IL (1) IL278013B2 (it)
LT (1) LT3781561T (it)
MA (1) MA52288B1 (it)
MD (1) MD3781561T2 (it)
MX (1) MX2020010999A (it)
PE (1) PE20201448A1 (it)
PH (1) PH12020551578A1 (it)
PL (1) PL3781561T3 (it)
PT (1) PT3781561T (it)
RS (1) RS65621B1 (it)
SG (1) SG11202009438UA (it)
SI (1) SI3781561T1 (it)
SM (1) SMT202400233T1 (it)
TW (1) TWI828677B (it)
UA (1) UA127357C2 (it)
WO (1) WO2019204490A1 (it)

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KR102798145B1 (ko) * 2018-04-18 2025-04-22 콘스텔레이션 파마슈티칼스, 인크. 메틸 변형 효소 조절제, 이의 조성물 및 용도
EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
KR102689665B1 (ko) 2019-02-19 2024-07-31 한미약품 주식회사 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도
MX2022000931A (es) * 2019-07-24 2022-05-03 Constellation Pharmaceuticals Inc Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidin-1-il) ciclohexil)-2, 4- dimetil-n-((6-metil-4-(metiltio)-2-oxo-1, 2-dihidropiridin-3-il) metil) benzo [d] [1, 3] dioxol-5-carboxamida.
PH12022550189A1 (en) * 2019-07-24 2022-11-21 Constellation Pharmaceuticals Inc Ezh2 inhibition in combination therapies for the treatment of cancers
TW202144341A (zh) * 2020-03-13 2021-12-01 大陸商四川海思科製藥有限公司 Zeste同源基因增強子2抑制劑及其用途
CN113666920A (zh) * 2020-04-14 2021-11-19 上海华汇拓医药科技有限公司 苯并恶唑类化合物制备方法及其在医药领域的应用
KR20230037488A (ko) * 2020-07-08 2023-03-16 다이이찌 산쿄 가부시키가이샤 1,3-벤조디옥솔 유도체의 제조 방법
EP4247371B1 (en) * 2020-11-18 2025-01-01 Constellation Pharmaceuticals, Inc. Ezh2 inhibition therapies for the treatment of androgen receptor mutated prostate cancers
KR20220101295A (ko) 2021-01-11 2022-07-19 주식회사 엘지에너지솔루션 전극 슬러리의 유량 제어가 가능한 전극 슬러리 코팅 시스템 및 이를 이용한 전극 슬러리 코팅 방법
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