SK283335B6 - (Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze - Google Patents

(Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze Download PDF

Info

Publication number: SK283335B6
Authority: SK; Slovakia
Prior art keywords: alkyl; methyl; formula; imidazol; quinolinone
Prior art date: 1995-12-08

Application number

SK704-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK70498A3 (en

Inventor

Marc Gaston Venet

Patrick Ren Angibaud

Philippe Muller

G�Rard Charles Sanz

Original Assignee

Janssen Pharmaceutica N. V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-08

Filing date

1996-10-16

Publication date

2003-06-03

1996-10-16 Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.

1998-10-07 Publication of SK70498A3 publication Critical patent/SK70498A3/sk

2003-06-03 Publication of SK283335B6 publication Critical patent/SK283335B6/sk

Links

239000000543 intermediate Substances 0.000 title claims abstract description 101
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239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 12
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IKMMPHALUZQNMN-UHFFFAOYSA-N 3-(1h-imidazol-5-ylmethyl)-1h-quinolin-2-one Chemical class O=C1NC2=CC=CC=C2C=C1CC1=CN=CN1 IKMMPHALUZQNMN-UHFFFAOYSA-N 0.000 title abstract 2
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ALKQAQOKGRWMSJ-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-ethoxyphenyl)-1-methylquinolin-2-one Chemical compound CCOC1=CC=CC(C=2C3=CC(=CC=C3N(C)C(=O)C=2)C(N)(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 ALKQAQOKGRWMSJ-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK704-98A 1995-12-08 1996-10-16 (Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze SK283335B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95203427		1995-12-08
PCT/EP1996/004515 WO1997021701A1 (en)	1995-12-08	1996-10-16	Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives

Publications (2)

Publication Number	Publication Date
SK70498A3 SK70498A3 (en)	1998-10-07
SK283335B6 true SK283335B6 (sk)	2003-06-03

Family

ID=8220926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK704-98A SK283335B6 (sk)	1995-12-08	1996-10-16	(Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze

Country Status (36)

Country	Link
US (3)	US6037350A (uk)
EP (2)	EP1162201B1 (uk)
JP (1)	JP3257559B2 (uk)
KR (1)	KR100272676B1 (uk)
CN (1)	CN1101392C (uk)
AP (1)	AP1108A (uk)
AR (1)	AR004992A1 (uk)
AT (2)	ATE215541T1 (uk)
AU (1)	AU711142B2 (uk)
BG (1)	BG62615B1 (uk)
BR (1)	BR9610745A (uk)
CA (1)	CA2231105C (uk)
CY (1)	CY2289B1 (uk)
CZ (1)	CZ293296B6 (uk)
DE (2)	DE69620445T2 (uk)
DK (2)	DK1162201T3 (uk)
EA (1)	EA000710B1 (uk)
EE (1)	EE03484B1 (uk)
ES (2)	ES2260156T3 (uk)
HK (2)	HK1012188A1 (uk)
HR (1)	HRP960576B1 (uk)
HU (1)	HU221227B1 (uk)
IL (1)	IL123568A (uk)
MX (1)	MX9802068A (uk)
MY (1)	MY114444A (uk)
NO (1)	NO314036B1 (uk)
NZ (1)	NZ320244A (uk)
PL (1)	PL184171B1 (uk)
PT (2)	PT1162201E (uk)
SI (2)	SI0865440T1 (uk)
SK (1)	SK283335B6 (uk)
TR (1)	TR199800825T2 (uk)
TW (1)	TW494101B (uk)
UA (1)	UA57717C2 (uk)
WO (1)	WO1997021701A1 (uk)
ZA (1)	ZA9610254B (uk)

Families Citing this family (234)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI0865440T1 (en) *	1995-12-08	2002-08-31	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives
ES2182327T3 (es) *	1997-06-02	2003-03-01	Janssen Pharmaceutica Nv	Derivados de (imidazol-5-il)metil-2-quinlinona como inhibidores de la proliferacion de celulas de musculos lisos.
US20030114503A1 (en) *	1997-06-16	2003-06-19	Pfizer Inc.	Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the treatment of cancer
DK1097150T3 (da) *	1998-06-16	2004-07-26	Sod Conseils Rech Applic	Imidazolylderivater
US6420555B1 (en)	1998-06-16	2002-07-16	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Imidazolyl derivatives
SI1094815T1 (en) *	1998-07-06	2004-04-30	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitors for treating arthropathies
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ES2260156T3 (es)	2006-11-01
EA000710B1 (ru)	2000-02-28
CY2289B1 (en)	2003-07-04
MY114444A (en)	2002-10-31
EP1162201A9 (en)	2002-04-03
CA2231105C (en)	2005-09-13
CN1101392C (zh)	2003-02-12
IL123568A (en)	2001-08-08
UA57717C2 (uk)	2003-07-15
MX9802068A (es)	1998-08-30
NZ320244A (en)	1999-06-29
EP0865440B1 (en)	2002-04-03
EA199800443A1 (ru)	1998-10-29
NO314036B1 (no)	2003-01-20
BG102458A (en)	1999-06-30
KR100272676B1 (ko)	2000-11-15
PL184171B1 (pl)	2002-09-30
ATE321757T1 (de)	2006-04-15
CZ157398A3 (cs)	1998-10-14
DK0865440T3 (da)	2002-07-22
CN1203598A (zh)	1998-12-30
BG62615B1 (en)	2000-03-31
EP1162201B1 (en)	2006-03-29
HK1012188A1 (en)	1999-07-30
AU7294896A (en)	1997-07-03
WO1997021701A1 (en)	1997-06-19
JP3257559B2 (ja)	2002-02-18
PL325962A1 (en)	1998-08-17
DE69620445T2 (de)	2002-12-12
PT1162201E (pt)	2006-08-31
DE69635966T2 (de)	2006-11-30
ZA9610254B (en)	1998-06-05
SI1162201T1 (sl)	2006-08-31
SK70498A3 (en)	1998-10-07
ATE215541T1 (de)	2002-04-15
CZ293296B6 (cs)	2004-03-17
HU221227B1 (en)	2002-08-28
HUP9900185A2 (hu)	1999-04-28
ES2175137T3 (es)	2002-11-16
US6420387B1 (en)	2002-07-16
HK1042482B (zh)	2006-06-09
HUP9900185A3 (en)	1999-11-29
EP0865440A1 (en)	1998-09-23
US6169096B1 (en)	2001-01-02
AR004992A1 (es)	1999-04-07
PT865440E (pt)	2002-09-30
TR199800825T2 (xx)	1998-08-21
BR9610745A (pt)	1999-07-13
DE69635966D1 (de)	2006-05-18
NO980927L (no)	1998-06-08
HRP960576B1 (en)	2002-04-30
KR19990063891A (ko)	1999-07-26
SI0865440T1 (en)	2002-08-31
AP1108A (en)	2002-10-02
EP1162201A3 (en)	2003-11-26
AP9801257A0 (en)	1998-06-30
IL123568A0 (en)	1998-10-30
DK1162201T3 (da)	2006-07-17
HRP960576A2 (en)	1998-02-28
JPH10511405A (ja)	1998-11-04
EE9800146A (et)	1998-10-15
US6037350A (en)	2000-03-14
CA2231105A1 (en)	1997-06-19
HK1042482A1 (en)	2002-08-16
TW494101B (en)	2002-07-11
NO980927D0 (no)	1998-03-04
AU711142B2 (en)	1999-10-07
DE69620445D1 (de)	2002-05-08
EE03484B1 (et)	2001-08-15
EP1162201A2 (en)	2001-12-12

Publication	Publication Date	Title
SK283335B6 (sk)	2003-06-03	(Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze
EP1019395B1 (en)	2002-01-30	Farnesyl transferase inhibiting 2-quinolone derivatives
US6187786B1 (en)	2001-02-13	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
CZ371799A3 (cs)	2000-02-16	Chinazolinony inhibující farnesyltransferázu
MXPA98002067A (en)	1998-11-12	Derivatives of the 2-quinolone inhibitors of the farnesil transfer

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