SMT201700347T1 - Modulatori di ror-gamma-t chinolinilici legati a metilene - Google Patents

Modulatori di ror-gamma-t chinolinilici legati a metilene

Info

Publication number: SMT201700347T1
Authority: SM; San Marino
Prior art keywords: ror; modulators; gamma; methylene; linked quinolinyl
Prior art date: 2012-10-16

Application number

SM20170347T

Other languages

English (en)

Inventor

Steven Goldberg

Kristi A Leonard

Kent Barbay

James P Edwards

Kevin D Kreutter

David A Kummer

Umar Maharoof

Rachel Nishimura

Maud Urbanski

Hariharan Venkatesan

Aihua Wang

Ronald L Wolin

Craig R Woods

Joan Pierce

Anne Fourie

Xiaohua Xue

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-10-16

Filing date

2013-10-15

Publication date

2017-09-07

2013-10-15 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2017-09-07 Publication of SMT201700347T1 publication Critical patent/SMT201700347T1/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)

SM20170347T 2012-10-16 2013-10-15 Modulatori di ror-gamma-t chinolinilici legati a metilene SMT201700347T1 (it)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201261714419P	2012-10-16	2012-10-16
US201261725528P	2012-11-13	2012-11-13
US201361782257P	2013-03-14	2013-03-14
EP13786564.8A EP2909192B1 (en)	2012-10-16	2013-10-15	Methylene linked quinolinyl modulators of ror-gamma-t
PCT/US2013/065013 WO2014062658A1 (en)	2012-10-16	2013-10-15	Methylene linked quinolinyl modulators of ror-gamma-t

Publications (1)

Publication Number	Publication Date
SMT201700347T1 true SMT201700347T1 (it)	2017-09-07

Family

ID=49546611

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM20170347T SMT201700347T1 (it)	2012-10-16	2013-10-15	Modulatori di ror-gamma-t chinolinilici legati a metilene

Country Status (38)

Country	Link
US (1)	US9290476B2 (it)
EP (1)	EP2909192B1 (it)
JP (1)	JP6466335B2 (it)
KR (1)	KR20150070347A (it)
CN (1)	CN105209453B (it)
AR (1)	AR093017A1 (it)
AU (1)	AU2013331496B2 (it)
BR (1)	BR112015008308A2 (it)
CA (1)	CA2888210C (it)
CL (1)	CL2015000945A1 (it)
CR (1)	CR20150193A (it)
CY (1)	CY1119234T1 (it)
DK (1)	DK2909192T3 (it)
EA (1)	EA026415B1 (it)
EC (1)	ECSP15015022A (it)
ES (1)	ES2632269T3 (it)
GT (1)	GT201500093A (it)
HR (1)	HRP20171082T1 (it)
HU (1)	HUE035335T2 (it)
IL (1)	IL237866B (it)
LT (1)	LT2909192T (it)
ME (1)	ME02794B (it)
MX (1)	MX358508B (it)
MY (1)	MY189505A (it)
NI (1)	NI201500053A (it)
NZ (1)	NZ706775A (it)
PE (1)	PE20150778A1 (it)
PH (1)	PH12015500817B1 (it)
PL (1)	PL2909192T3 (it)
PT (1)	PT2909192T (it)
RS (1)	RS56283B1 (it)
SG (1)	SG11201502369XA (it)
SI (1)	SI2909192T1 (it)
SM (1)	SMT201700347T1 (it)
TW (1)	TWI606045B (it)
UY (1)	UY35084A (it)
WO (1)	WO2014062658A1 (it)
ZA (1)	ZA201503418B (it)

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JOP20210058A1 (ar)	2018-09-28	2021-03-24	Janssen Pharmaceutica Nv	مُعدلات ليباز أُحادِيُّ الجلِيسِريد
US10947253B2 (en)	2019-08-05	2021-03-16	Ankh Life Sciences Limited	Fused polycyclic dimers
AU2020358948A1 (en)	2019-09-30	2022-05-26	Janssen Pharmaceutica Nv	Radiolabelled MGL PET ligands
EP4053109A4 (en) *	2019-10-31	2022-12-21	Jiangsu Hengrui Medicine Co., Ltd.	ACID ADDITION SALT OF RORy REGULATOR
CN115335378B (zh)	2020-03-26	2025-03-04	詹森药业有限公司	单酰基甘油脂肪酶调节剂
EP4143179A1 (en)	2020-04-30	2023-03-08	Idorsia Pharmaceuticals Ltd	Azetidin-3-ylmethanol derivatives as ccr6 receptor modulators
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CN112939974B (zh) *	2021-03-11	2023-10-20	中山大学	一种氮杂苯并薁衍生物的制备方法
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Publication number	Publication date
TW201427969A (zh)	2014-07-16
WO2014062658A1 (en)	2014-04-24
BR112015008308A2 (pt)	2017-12-05
AU2013331496B2 (en)	2017-07-27
MY189505A (en)	2022-02-16
ECSP15015022A (es)	2016-01-29
PE20150778A1 (es)	2015-05-23
KR20150070347A (ko)	2015-06-24
JP2015536320A (ja)	2015-12-21
SG11201502369XA (en)	2015-05-28
NI201500053A (es)	2020-03-18
IL237866B (en)	2018-05-31
PT2909192T (pt)	2017-08-04
AR093017A1 (es)	2015-05-13
UY35084A (es)	2014-04-30
NZ706775A (en)	2018-10-26
US20140107094A1 (en)	2014-04-17
CA2888210A1 (en)	2014-04-24
PH12015500817A1 (en)	2015-06-08
RS56283B1 (sr)	2017-12-29
HUE035335T2 (en)	2018-05-02
ME02794B (me)	2018-01-20
GT201500093A (es)	2017-09-26
JP6466335B2 (ja)	2019-02-06
AU2013331496A1 (en)	2015-04-09
DK2909192T3 (en)	2017-08-07
MX358508B (es)	2018-08-22
CN105209453A (zh)	2015-12-30
US9290476B2 (en)	2016-03-22
CR20150193A (es)	2015-05-18
ZA201503418B (en)	2017-11-29
TWI606045B (zh)	2017-11-21
HK1213248A1 (en)	2016-06-30
EP2909192A1 (en)	2015-08-26
MX2015004783A (es)	2015-08-14
SI2909192T1 (sl)	2017-08-31
PL2909192T3 (pl)	2017-09-29
ES2632269T3 (es)	2017-09-12
EP2909192B1 (en)	2017-05-17
PH12015500817B1 (en)	2015-06-08
LT2909192T (lt)	2017-07-10
CY1119234T1 (el)	2018-02-14
CL2015000945A1 (es)	2015-08-28
HRP20171082T1 (hr)	2017-10-06
EA201590736A1 (ru)	2015-09-30
CA2888210C (en)	2021-02-09
EA026415B1 (ru)	2017-04-28
WO2014062658A8 (en)	2014-07-10
CN105209453B (zh)	2017-06-20

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