SI9520084B - Uporaba hetrocikličnih spojin kot dopamin-d3-ligandov - Google Patents
Uporaba hetrocikličnih spojin kot dopamin-d3-ligandov Download PDFInfo
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- SI9520084B SI9520084B SI9520084A SI9520084A SI9520084B SI 9520084 B SI9520084 B SI 9520084B SI 9520084 A SI9520084 A SI 9520084A SI 9520084 A SI9520084 A SI 9520084A SI 9520084 B SI9520084 B SI 9520084B
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- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 11
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 2
- 108010081348 HRT1 protein Hairy Proteins 0.000 claims 2
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- VKVJIWVUYNTBEZ-UHFFFAOYSA-N 1,3-bis(3,5-dichlorophenyl)urea Chemical compound ClC1=CC(Cl)=CC(NC(=O)NC=2C=C(Cl)C=C(Cl)C=2)=C1 VKVJIWVUYNTBEZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 claims 1
- 206010029333 Neurosis Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000015238 neurotic disease Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 102000004073 Dopamine D3 Receptors Human genes 0.000 abstract 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (11)
- 4 Patentni zahtevki 1. Uporaba spojin s formulo I: Het-A-B-Ar kjer A stoji za nerazvejeno ali razvejeno Cj-Cis-alkilensko skupino, ki lahko po izbiri obsega vsaj eno skupino, ki je izbrana izmed O, S, NR4, CONR4, NR4CO, COO, OCO in dvojne ali trojne vezi, B stoji za ostanek s formulo:ali Ar stoji za fenil, piridil, pirimidil ali triazinil, pri čemer ima lahko Ar po izbiri enega do štiri substituente, ki so neodvisno eden od drugega izbrani izmed OR4, Ci-Cg-alkila, C2-C8-alkenila, C2-C8-alkinila, halogena, CN, CO2R4, NO2, SO2R4, SO3R4, NR4R5, S02NR4R5, SR4, CF3, CHF2, 5- ali 6-členskega karbocikličnega, aromatskega ali nearomatskega obroča in 5- ali 6-členskega heterocikličnega aromatskega ali nearomatskega obroča z 1 do 3 heteroatomi, ki so izbrani izmed O, S in N, pri čemer je karbociklični ali heterociklični obroč po izbiri substituiran s Ci-Cs -alkilom, halogenom, OCj-Cs-alkilom, OH, NO2 ali CF3 in pri čemer je lahko Ar po izbiri kondenziran tudi z karbocikličnim ali heterocikličnim obročem zgoraj definirane vrste, stoji za skupino, kije izbrana izmedR2 in R2 stojijo neodvisno eden od drugega za H, halogen, OR-*, NR^R^, SR^, CF3, CN, C02R^ ali Ci-Cg-alkil, ki je po izbiri substituiran z OH, OCi-Cg-alkilom ali halogenom, 3 R4 stoji za H ali Cj-Cg-alkil, ki je po izbiri substituiran z OH, OCi-Cg-alkilom ali halogenom; R5 ima pomene, navedene za R4 ali stoji za COR4 ali CO2R4; R8 ima pomene, navedene za R~\ in njihovih soli s fiziološko prenesljivimi kislinami, za pripravo farmacevtskega sredstva za zdravljenje shizofrenije, depresij, nevroz in psihoz.
- 2. Uporaba po zahtevku 1 spojin s formulo I, kjer Het stoji za skupino s splošno formulo R2 R
- 3. Uporaba po zahtevku 2 spojin s formulo I, kjer Het stoji za ostanek s splošno formulo:
- 4. Uporaba po zahtevku 2 spojin s formulo I, kjer Het stoji za ostanek s splošno formulo:s
- 5. Uporaba po enem od predhodnih zahtevkov spojin s formulo I, kjer A stoji za Ci-Cg-alkilensko skupino, ki po izbiri obsega O, S ali CONR4 in Ar stoji za fenil ali piridil, ki ima po izbiri en ali dva substituenta, ki sta neodvisno eden od drugega izbrana izmed H, Cj-Cg-alkila, OC i-Cg-alkila, CHF2, CF3, CN, halogena, SO2OR4 in CO2R4 pri čemer ima R4 v zahtevku 1 navedene pomene.
- 6. Uporaba po zahtevku 5 spojin s formulo I, kjer A stoji za C3-C()-alkilensko skupino, ki lahko po izbiri vsebuje S, O ali CONR4, ima Ar po izbiri enega ali dva substituenta, ki sta neodvisno eden od drugega izbrana izmed H, CF3, halogena, Ci-Cs-alkila, OCi-Cg-alkila in CN, in B stoji za Γ\ i >
- 7. Uporaba po zahtevku 6 spojin s formulo I, kjer R1, R2 in R2 vsakokrat neodvisno eden od drugega stojijo za H, NR4R5, OR5, Ci-Cg-alkil, CO2R4, CF3 ali halogen, R4 stoji za H, Ci-Cs-alkil, R5 stoji za H, C]-C8-alkil ali CO-Ci-Cs-alkil in R^ stoji za H ali Ci-Cs-alkil.
- 8. Uporaba po enem od predhodnih zahtevkov spojin s formulo I, kjer A stoji za C3-C6-alkilensko skupino, ki lahko po izbiri vsebuje S, O ali CONH, B stoji za vy w in je ali so substituenti ostanka Ar neodvisno eden od drugega izbrani izmed H, CHF2, Ci-C4-alkila ali CF3.
- 9. Uporaba po enem od predhodnih zahtevkov spojin s formulo la: Hrt-r kjer Het in A posedujeta pomene, ki so navedeni v enem od predhodnih zahtevkov, in sta X in Y definirana kot substituenta ostanka Ar.
- 10. Uporaba po zahtevku 9 spojin s formulo Ib: Y Het- v_y X kjer Het, A, X in Y posedujejo v zahtevku 9 navedene pomene.
- 11. Uporaba po zahtevku 9 ali 10, pri čemer Y stoji za H ali Ci -C4-alkil in stoji X za CF3, CHF2, CN, Ci-C4-alkil.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4425146A DE4425146A1 (de) | 1994-07-15 | 1994-07-15 | Verwendung heterocyclischer Verbindungen |
| PCT/EP1995/002782 WO1996002246A1 (de) | 1994-07-15 | 1995-07-14 | Verwendung heterocyclischer verbindungen als dopamin-d3 liganden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9520084A SI9520084A (en) | 1997-08-31 |
| SI9520084B true SI9520084B (sl) | 2005-02-28 |
Family
ID=6523325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9520084A SI9520084B (sl) | 1994-07-15 | 1995-07-14 | Uporaba hetrocikličnih spojin kot dopamin-d3-ligandov |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6090807A (sl) |
| EP (1) | EP0771197B1 (sl) |
| JP (1) | JPH10502658A (sl) |
| KR (2) | KR970704435A (sl) |
| CN (2) | CN1152870A (sl) |
| AT (1) | ATE236629T1 (sl) |
| AU (1) | AU704839B2 (sl) |
| BG (1) | BG63487B1 (sl) |
| BR (1) | BR9508296A (sl) |
| CA (1) | CA2195242A1 (sl) |
| CZ (1) | CZ293126B6 (sl) |
| DE (2) | DE4425146A1 (sl) |
| DK (1) | DK0771197T3 (sl) |
| ES (1) | ES2196072T3 (sl) |
| FI (1) | FI970148A0 (sl) |
| HU (1) | HUT77608A (sl) |
| MX (1) | MX9700430A (sl) |
| NO (1) | NO311683B1 (sl) |
| NZ (1) | NZ290388A (sl) |
| PT (1) | PT771197E (sl) |
| SI (1) | SI9520084B (sl) |
| WO (1) | WO1996002246A1 (sl) |
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| JP4108747B2 (ja) * | 1995-07-13 | 2008-06-25 | アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 治療薬としてのピペラジン誘導体 |
| DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| JP2000510137A (ja) * | 1996-05-11 | 2000-08-08 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ドーパミンｄ３受容体のモジュレーターとしてのテトラヒドロイソキノリン誘導体 |
| WO1998006699A1 (en) * | 1996-08-14 | 1998-02-19 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives and their pharmaceutical use |
| GB9708694D0 (en) * | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
| GB9708805D0 (en) * | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9709303D0 (en) * | 1997-05-09 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
| TW530054B (en) * | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
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| GB9810876D0 (en) * | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| OA11663A (en) | 1998-10-08 | 2004-12-08 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors recptors (antipsychotic agents). |
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| DE2513940A1 (de) * | 1975-03-29 | 1976-10-14 | Merck Patent Gmbh | Pharmazeutische zubereitung |
| US4123529A (en) * | 1976-04-23 | 1978-10-31 | Lilly Industries Limited | Phenylpiperazine derivatives |
| US4404382A (en) * | 1980-09-17 | 1983-09-13 | The Upjohn Company | Piperazinyl-substituted imidazoles |
| US5254552A (en) * | 1988-05-24 | 1993-10-19 | American Home Products Corporation | Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity |
| AU645681B2 (en) * | 1991-05-02 | 1994-01-20 | John Wyeth & Brother Limited | Piperazine derivatives |
| FR2682953B1 (fr) * | 1991-10-23 | 1995-04-21 | Inst Nat Sante Rech Med | Nouveaux derives de naphtamides, leur procede de preparation et leur application dans le domaine therapeutique. |
| EP0558245A1 (en) * | 1992-02-25 | 1993-09-01 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors |
| IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
| US5395835A (en) * | 1994-03-24 | 1995-03-07 | Warner-Lambert Company | Naphthalamides as central nervous system agents |
-
1994
- 1994-07-15 DE DE4425146A patent/DE4425146A1/de not_active Ceased
-
1995
- 1995-07-14 WO PCT/EP1995/002782 patent/WO1996002246A1/de active IP Right Grant
- 1995-07-14 CN CN95194149A patent/CN1152870A/zh active Pending
- 1995-07-14 KR KR1019970700265A patent/KR970704435A/ko active Search and Examination
- 1995-07-14 AT AT95926896T patent/ATE236629T1/de not_active IP Right Cessation
- 1995-07-14 HU HU9700111A patent/HUT77608A/hu unknown
- 1995-07-14 SI SI9520084A patent/SI9520084B/sl not_active IP Right Cessation
- 1995-07-14 EP EP95926896A patent/EP0771197B1/de not_active Expired - Lifetime
- 1995-07-14 ES ES95926896T patent/ES2196072T3/es not_active Expired - Lifetime
- 1995-07-14 CA CA002195242A patent/CA2195242A1/en not_active Abandoned
- 1995-07-14 CZ CZ199796A patent/CZ293126B6/cs not_active IP Right Cessation
- 1995-07-14 MX MX9700430A patent/MX9700430A/es not_active IP Right Cessation
- 1995-07-14 NZ NZ290388A patent/NZ290388A/en unknown
- 1995-07-14 DK DK95926896T patent/DK0771197T3/da active
- 1995-07-14 US US08/765,181 patent/US6090807A/en not_active Expired - Lifetime
- 1995-07-14 AU AU31114/95A patent/AU704839B2/en not_active Ceased
- 1995-07-14 KR KR10-2003-7012315A patent/KR100443850B1/ko not_active IP Right Cessation
- 1995-07-14 CN CNA2003101131172A patent/CN1534023A/zh active Pending
- 1995-07-14 DE DE59510635T patent/DE59510635D1/de not_active Expired - Lifetime
- 1995-07-14 PT PT95926896T patent/PT771197E/pt unknown
- 1995-07-14 JP JP8504701A patent/JPH10502658A/ja not_active Ceased
- 1995-07-14 BR BR9508296A patent/BR9508296A/pt active Search and Examination
-
1997
- 1997-01-06 BG BG101112A patent/BG63487B1/bg unknown
- 1997-01-14 NO NO19970163A patent/NO311683B1/no not_active IP Right Cessation
- 1997-01-14 FI FI970148A patent/FI970148A0/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2196072T3 (es) | 2003-12-16 |
| NZ290388A (en) | 2001-04-27 |
| FI970148A (fi) | 1997-01-14 |
| CN1152870A (zh) | 1997-06-25 |
| DE4425146A1 (de) | 1996-01-18 |
| US6090807A (en) | 2000-07-18 |
| PT771197E (pt) | 2003-08-29 |
| EP0771197B1 (de) | 2003-04-09 |
| NO970163D0 (no) | 1997-01-14 |
| AU3111495A (en) | 1996-02-16 |
| KR100443850B1 (ko) | 2004-08-11 |
| CN1534023A (zh) | 2004-10-06 |
| BG101112A (en) | 1998-04-30 |
| SI9520084A (en) | 1997-08-31 |
| FI970148A0 (fi) | 1997-01-14 |
| BG63487B1 (bg) | 2002-03-29 |
| EP0771197A1 (de) | 1997-05-07 |
| DE59510635D1 (de) | 2003-05-15 |
| NO970163L (no) | 1997-03-14 |
| HUT77608A (hu) | 1998-06-29 |
| KR970704435A (ko) | 1997-09-06 |
| CZ293126B6 (cs) | 2004-02-18 |
| JPH10502658A (ja) | 1998-03-10 |
| KR20040000412A (ko) | 2004-01-03 |
| HU9700111D0 (en) | 1997-02-28 |
| CA2195242A1 (en) | 1996-02-01 |
| BR9508296A (pt) | 1998-05-19 |
| NO311683B1 (no) | 2002-01-07 |
| MX9700430A (es) | 1998-05-31 |
| DK0771197T3 (da) | 2003-06-23 |
| AU704839B2 (en) | 1999-05-06 |
| ATE236629T1 (de) | 2003-04-15 |
| WO1996002246A1 (de) | 1996-02-01 |
| CZ9697A3 (en) | 1997-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20041129 |
|
| KO00 | Lapse of patent |
Effective date: 20050412 |