SI9520078B - Polsintetski taksani z antitumorsko aktivnostjo - Google Patents

Polsintetski taksani z antitumorsko aktivnostjo Download PDF

Info

Publication number: SI9520078B
Authority: SI; Slovenia
Prior art keywords: formula; tert; phenyl; propanoyl; hydroxy
Prior art date: 1994-07-26

Application number

SI9520078A

Other languages

English (en)

Slovenian (sl)

Other versions

SI9520078A (en

Inventor

Ezio Bombardelli

Bellis Paolo De

Bruno Gabetta

Original Assignee

Indena S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-26

Filing date

1995-07-21

Publication date

1998-12-31

1994-07-26 Priority claimed from ITMI941592A external-priority patent/IT1274356B/it

1995-06-19 Priority claimed from IT95RM000413A external-priority patent/IT1278108B1/it

1995-07-21 Application filed by Indena S.P.A. filed Critical Indena S.P.A.

1997-06-30 Publication of SI9520078A publication Critical patent/SI9520078A/sl

1998-12-31 Publication of SI9520078B publication Critical patent/SI9520078B/sl

Links

229940123237 Taxane Drugs 0.000 title claims 3
230000000259 anti-tumor effect Effects 0.000 title abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims abstract 2
150000001875 compounds Chemical class 0.000 claims 5
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
206010028980 Neoplasm Diseases 0.000 claims 1
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
125000002252 acyl group Chemical group 0.000 claims 1
125000003118 aryl group Chemical group 0.000 claims 1
-1 caproyl Chemical group 0.000 claims 1
230000003130 cardiopathic effect Effects 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
125000001072 heteroaryl group Chemical group 0.000 claims 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
238000000034 method Methods 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
125000006239 protecting group Chemical group 0.000 claims 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical class O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)

SI9520078A 1994-07-26 1995-07-21 Polsintetski taksani z antitumorsko aktivnostjo SI9520078B (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI941592A IT1274356B (it)	1994-07-26	1994-07-26	Tassani semisintetici odtati di attivita' antitumorale
IT95RM000413A IT1278108B1 (it)	1995-06-19	1995-06-19	Secotassani dotati di attivita' antitumorale.
PCT/EP1995/002896 WO1996003394A1 (fr)	1994-07-26	1995-07-21	Taxanes semi-synthetiques presentant une activite antitumorale

Publications (2)

Publication Number	Publication Date
SI9520078A SI9520078A (en)	1997-06-30
SI9520078B true SI9520078B (sl)	1998-12-31

Family

ID=26331178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9520078A SI9520078B (sl)	1994-07-26	1995-07-21	Polsintetski taksani z antitumorsko aktivnostjo

Country Status (24)

Country	Link
US (1)	US5756776A (fr)
EP (1)	EP0773938B1 (fr)
JP (1)	JP2986550B2 (fr)
KR (1)	KR100220490B1 (fr)
CN (4)	CN1073105C (fr)
AT (1)	ATE176464T1 (fr)
AU (1)	AU684218B2 (fr)
BG (1)	BG62851B1 (fr)
CA (1)	CA2195844C (fr)
CZ (1)	CZ293076B6 (fr)
DE (1)	DE69507702T2 (fr)
DK (1)	DK0773938T3 (fr)
ES (1)	ES2126919T3 (fr)
FI (1)	FI120398B (fr)
GR (1)	GR3029309T3 (fr)
HK (1)	HK1011687A1 (fr)
HU (1)	HU222496B1 (fr)
NO (1)	NO315116B1 (fr)
PL (1)	PL187579B1 (fr)
RO (2)	RO115875B1 (fr)
RU (1)	RU2134688C1 (fr)
SI (1)	SI9520078B (fr)
SK (1)	SK281526B6 (fr)
WO (1)	WO1996003394A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6107332A (en)	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
AU7130098A (en) *	1995-10-26	1998-12-30	Baker Norton Pharmaceuticals, Inc.	Method and compositions for administering taxanes orally to human patients
US6395770B1 (en) *	1995-10-26	2002-05-28	Baker Norton Pharmaceuticals, Inc.	Method and compositions for administering taxanes orally to human patients
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EP0868422A1 (fr) *	1996-09-24	1998-10-07	Marigen S.A.	Ultramicroemulsions constituees de concentres pouvant etre disperses de fa on spontanne, renfermant des esters de composes de baccatine-iii a effet antitumoral et antiviral
US5773464A (en) *	1996-09-30	1998-06-30	Bristol-Myers Squibb Company	C-10 epoxy taxanes
US5977386A (en) *	1996-12-24	1999-11-02	Bristol-Myers Squibb Company	6-thio-substituted paclitaxels
US5902822A (en) *	1997-02-28	1999-05-11	Bristol-Myers Squibb Company	7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) *	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US6017935A (en) *	1997-04-24	2000-01-25	Bristol-Myers Squibb Company	7-sulfur substituted paclitaxels
IT1308636B1 (it) *	1999-03-02	2002-01-09	Indena Spa	Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
EP1229934B1 (fr)	1999-10-01	2014-03-05	Immunogen, Inc.	Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
IT1317731B1 (it)	2000-01-18	2003-07-15	Indena Spa	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
US6649632B2 (en) *	2000-02-02	2003-11-18	Fsu Research Foundation, Inc.	C10 ester substituted taxanes
EP1129991A1 (fr) *	2000-03-02	2001-09-05	Degussa AG	Procédé de préparation d'une zéolite contenant du titane
US7064980B2 (en) *	2003-09-17	2006-06-20	Sandisk Corporation	Non-volatile memory and method with bit line coupled compensation
HN2005000054A (es) *	2004-02-13	2009-02-18	Florida State University Foundation Inc	Taxanos sustituidos con esteres de ciclopentilo en c10
JP2008530122A (ja) *	2005-02-14	2008-08-07	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	Ｃ１０シクロプロピルエステル置換タキサン組成物
ITMI20050415A1 (it) *	2005-03-15	2006-09-16	Indena Spa	Derivati tassanici semi-sintetici ad attivita' antitumorale
ITMI20062479A1 (it) *	2006-12-21	2008-06-22	Indena Spa	Processo per la preparazione di secotassani
EP2183234A4 (fr) *	2007-08-22	2012-02-29	Canada Inc 6570763	Procédé de conversion de la 9-dihydro-13-acétylbaccatine iii en docétaxel ou paclitaxel
JP2011517455A (ja) *	2008-03-31	2011-06-09	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン
US8637466B2 (en)	2008-08-11	2014-01-28	Nektar Therapeutics	Multi-arm polymeric alkanoate conjugates
WO2012088445A1 (fr)	2010-12-22	2012-06-28	Nektar Therapeutics	Conjugués promédicaments polymères à plusieurs bras de composés à base de cabazitaxel
US20130331443A1 (en)	2010-12-22	2013-12-12	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088391A1 (fr) *	2010-12-22	2012-06-28	Nektar Therapeutics	Taxanes substitués par hydroxy, non cycliques, et leurs procédés de synthèse
US20130338216A1 (en) *	2010-12-22	2013-12-19	Nektar Therapeutics	Deuterated and/or fluorinated taxane derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
CA2092705C (fr) *	1991-07-17	1995-11-07	Koji Saito	Compose presentant une action antitumorale, nsc-lsc1, et procede de fabrication dudit compose
US5399726A (en) *	1993-01-29	1995-03-21	Florida State University	Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
FR2688499B1 (fr) *	1992-03-10	1994-05-06	Rhone Poulenc Rorer Sa	Procede de preparation de la beta-phenylisoserine et de ses analogues.
US5200534A (en) *	1992-03-13	1993-04-06	University Of Florida	Process for the preparation of taxol and 10-deacetyltaxol

1995
- 1995-07-21 AT AT95927699T patent/ATE176464T1/de active
- 1995-07-21 CZ CZ1997199A patent/CZ293076B6/cs not_active IP Right Cessation
- 1995-07-21 RO RO97-00125A patent/RO115875B1/ro unknown
- 1995-07-21 PL PL95318289A patent/PL187579B1/pl not_active IP Right Cessation
- 1995-07-21 SK SK100-97A patent/SK281526B6/sk not_active IP Right Cessation
- 1995-07-21 SI SI9520078A patent/SI9520078B/sl not_active IP Right Cessation
- 1995-07-21 KR KR1019970700442A patent/KR100220490B1/ko not_active Expired - Fee Related
- 1995-07-21 WO PCT/EP1995/002896 patent/WO1996003394A1/fr active IP Right Grant
- 1995-07-21 HU HU9700206A patent/HU222496B1/hu not_active IP Right Cessation
- 1995-07-21 RO ROA200000502A patent/RO116549B1/ro unknown
- 1995-07-21 RU RU97102722A patent/RU2134688C1/ru not_active IP Right Cessation
- 1995-07-21 JP JP8505456A patent/JP2986550B2/ja not_active Ceased
- 1995-07-21 ES ES95927699T patent/ES2126919T3/es not_active Expired - Lifetime
- 1995-07-21 CA CA002195844A patent/CA2195844C/fr not_active Expired - Fee Related
- 1995-07-21 CN CN95194333A patent/CN1073105C/zh not_active Expired - Fee Related
- 1995-07-21 AU AU31641/95A patent/AU684218B2/en not_active Ceased
- 1995-07-21 DE DE69507702T patent/DE69507702T2/de not_active Expired - Lifetime
- 1995-07-21 DK DK95927699T patent/DK0773938T3/da active
- 1995-07-21 EP EP95927699A patent/EP0773938B1/fr not_active Expired - Lifetime
- 1995-07-24 US US08/505,924 patent/US5756776A/en not_active Expired - Lifetime
1997
- 1997-01-23 BG BG101165A patent/BG62851B1/bg unknown
- 1997-01-23 FI FI970271A patent/FI120398B/fi not_active IP Right Cessation
- 1997-01-23 NO NO19970296A patent/NO315116B1/no not_active IP Right Cessation
1998
- 1998-12-07 HK HK98112903A patent/HK1011687A1/xx not_active IP Right Cessation
1999
- 1999-02-09 GR GR990400393T patent/GR3029309T3/el unknown
2000
- 2000-09-29 CN CN00129056A patent/CN1128795C/zh not_active Expired - Fee Related
- 2000-09-29 CN CN00129054A patent/CN1120161C/zh not_active Expired - Fee Related
- 2000-09-29 CN CN00129055A patent/CN1130356C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2986550B2 (ja)	1999-12-06
EP0773938A1 (fr)	1997-05-21
RU2134688C1 (ru)	1999-08-20
HK1011687A1 (en)	1999-07-16
CA2195844C (fr)	2001-10-09
JPH09512827A (ja)	1997-12-22
PL187579B1 (pl)	2004-08-31
NO970296L (no)	1997-03-12
CN1308073A (zh)	2001-08-15
RO115875B1 (ro)	2000-07-28
CZ19997A3 (en)	1997-07-16
CZ293076B6 (cs)	2004-02-18
AU3164195A (en)	1996-02-22
AU684218B2 (en)	1997-12-04
CN1073105C (zh)	2001-10-17
BG62851B1 (bg)	2000-09-29
DE69507702D1 (de)	1999-03-18
PL318289A1 (en)	1997-06-09
FI970271A0 (fi)	1997-01-23
CN1128795C (zh)	2003-11-26
CN1154109A (zh)	1997-07-09
EP0773938B1 (fr)	1999-02-03
DE69507702T2 (de)	1999-08-26
RO116549B1 (ro)	2001-03-30
SK10097A3 (en)	1997-08-06
WO1996003394A1 (fr)	1996-02-08
SK281526B6 (sk)	2001-04-09
GR3029309T3 (en)	1999-05-28
CN1120161C (zh)	2003-09-03
NO970296D0 (no)	1997-01-23
BG101165A (en)	1997-08-29
CN1130356C (zh)	2003-12-10
HUT76829A (en)	1997-11-28
FI120398B (fi)	2009-10-15
NO315116B1 (no)	2003-07-14
KR100220490B1 (ko)	1999-09-15
CN1308072A (zh)	2001-08-15
ES2126919T3 (es)	1999-04-01
CN1332163A (zh)	2002-01-23
FI970271L (fi)	1997-03-19
US5756776A (en)	1998-05-26
CA2195844A1 (fr)	1996-02-08
HU222496B1 (hu)	2003-07-28
DK0773938T3 (da)	1999-09-20
ATE176464T1 (de)	1999-02-15
SI9520078A (en)	1997-06-30

Publication	Publication Date	Title
SI9520078B (sl)	1998-12-31	Polsintetski taksani z antitumorsko aktivnostjo
DE69809959T2 (de)	2003-07-24	Neue taxanderivate
RU97102722A (ru)	1999-03-10	Полусинтетические таксаны с противоопухолевой активностью
KR970701708A (ko)	1997-04-12	9-데옥소탁산 화합물(9-Deoxotaxane compounds)
KR930006045A (ko)	1993-04-20	항종양 활성을 가진 피리미딘 뉴클레오사이드, 그의 제조방법 및 용도
KR960034178A (ko)	1996-10-22	벤자제핀- 벤즈옥사제핀- 및 벤조티아제핀-n- 아세트산 유도체와 그 제조방법 및 그들을 함유한 약제학적 조성물
ATE14423T1 (de)	1985-08-15	Hydroxamsaeurederivate vom typ der mannich-basen mit verbesserter biologischer verfuegbarkeit von nicht-steroiden entzuendungshemmern, verfahren zur herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzung.
SE8107274L (sv)	1982-06-06	1-sulfo-2-oxazetidinderivat, forfarande for framstellning derav och faramceutisk komposition innehallande desamma
KR900001686A (ko)	1990-02-27	4-옥소퀴놀린-3-카르복실산 유도체, 그의 제조방법 및 용도
ZA938214B (en)	1994-07-19	Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
GB8919417D0 (en)	1989-10-11	Novel compounds
RU95116366A (ru)	1997-06-10	Способ получения таксановых производных и бета -лактамные промежуточные соединения для них
CA2148103A1 (fr)	1994-05-11	Procede de preparation de derives du taxane
EP0815095B1 (fr)	2000-05-24	Derives de 10-deacetylbaccatine iii et de 10-deacetyl-14 beta-hydroxybaccatine iii, leur procede de preparation et compositions pharmaceutiques les contenant
RU2003134629A (ru)	2005-06-10	Соединения цефема
DE68926981D1 (de)	1996-09-26	Cephemverbindungen und Verfahren zu ihrer Herstellung
KR910700230A (ko)	1991-03-14	신규 히드록실아민 유도체
CA2373530A1 (fr)	2001-01-11	Derives de taxane et procedes de preparation de ceux-ci
FR2681864B1 (fr)	1995-03-31	Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES8701143A1 (es)	1986-11-16	Un procedimiento para la preparacion de nuevos aminas terciarias.
GB1421446A (en)	1976-01-21	Disalkylamino esters of benzopyranopyridines and compositions containing the same
HUP0204344A2 (en)	2003-05-28	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
ATE16278T1 (de)	1985-11-15	Hydroxybenzylamino-aryl verbindungen, verfahren zur deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen.
HU229257B1 (en)	2013-10-28	Condensation derivatives of thiocolchicine and baccatin as antitumor agents
KR930000527A (ko)	1993-01-15	칼슘-길항성 물질로서의 이노시톨 포스페이트 동족체

Legal Events

Date	Code	Title	Description
2005-01-10	IF	Valid on the event date
2013-04-30	KO00	Lapse of patent	Effective date: 20130304