IT1317731B1 - Tassani semisintetici con attivita' antitumorale ed antiangiogenetica. - Google Patents

Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.

Info

Publication number: IT1317731B1
Authority: IT; Italy
Prior art keywords: del; ins; sup; delete; date
Prior art date: 2000-01-18

Application number

IT2000MI000056A

Other languages

English (en)

Inventor

Ezio Bombardelli

Alessandro Pontiroli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-18

Filing date

2000-01-18

Publication date

2003-07-15

2000-01-18 Application filed by Indena Spa filed Critical Indena Spa

2000-01-18 Publication of ITMI20000056A0 publication Critical patent/ITMI20000056A0/it

2000-01-18 Priority to IT2000MI000056A priority Critical patent/IT1317731B1/it

2001-01-15 Priority to JP2001553757A priority patent/JP4986354B2/ja

2001-01-15 Priority to AU33694/01A priority patent/AU781650B2/en

2001-01-15 Priority to AT01905668T priority patent/ATE271044T1/de

2001-01-15 Priority to IL15078701A priority patent/IL150787A0/xx

2001-01-15 Priority to TR2004/01811T priority patent/TR200401811T4/xx

2001-01-15 Priority to DE60104281T priority patent/DE60104281T2/de

2001-01-15 Priority to PCT/EP2001/000386 priority patent/WO2001053282A1/en

2001-01-15 Priority to ES01905668T priority patent/ES2223778T3/es

2001-01-15 Priority to HU0204344A priority patent/HU229347B1/hu

2001-01-15 Priority to DK01905668T priority patent/DK1248776T3/da

2001-01-15 Priority to SI200130147T priority patent/SI1248776T1/xx

2001-01-15 Priority to PT01905668T priority patent/PT1248776E/pt

2001-01-15 Priority to CZ20022478A priority patent/CZ301251B6/cs

2001-01-15 Priority to CA002397591A priority patent/CA2397591C/en

2001-01-15 Priority to RU2002119060/04A priority patent/RU2259363C2/ru

2001-01-15 Priority to SK1056-2002A priority patent/SK285683B6/sk

2001-01-15 Priority to PL356272A priority patent/PL202591B1/pl

2001-01-15 Priority to CNB018038344A priority patent/CN1176916C/zh

2001-01-15 Priority to KR1020027009182A priority patent/KR100813704B1/ko

2001-01-15 Priority to EP01905668A priority patent/EP1248776B1/en

2001-07-18 Publication of ITMI20000056A1 publication Critical patent/ITMI20000056A1/it

2002-07-03 Priority to US10/187,995 priority patent/US6589979B2/en

2002-07-17 Priority to NO20023428A priority patent/NO329403B1/no

2003-03-19 Priority to HK03102021.6A priority patent/HK1049998B/zh

2003-07-15 Application granted granted Critical

2003-07-15 Publication of IT1317731B1 publication Critical patent/IT1317731B1/it

2005-06-20 Priority to US11/158,323 priority patent/USRE39723E1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Oncology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IT2000MI000056A 2000-01-18 2000-01-18 Tassani semisintetici con attivita' antitumorale ed antiangiogenetica. IT1317731B1 (it)

Priority Applications (25)

Application Number	Priority Date	Filing Date	Title
IT2000MI000056A IT1317731B1 (it)	2000-01-18	2000-01-18	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
PT01905668T PT1248776E (pt)	2000-01-18	2001-01-15	Taxanos semi-sinteticos com actividades antitumor e anti-angiogeneticas
CA002397591A CA2397591C (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
AT01905668T ATE271044T1 (de)	2000-01-18	2001-01-15	Semi-synthetische taxane mit antitumor und antiangiogenetischer wirkung
IL15078701A IL150787A0 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
TR2004/01811T TR200401811T4 (tr)	2000-01-18	2001-01-15	Antitümör ve antianjiyogenetik etkinlikleri olan yarı-sentetik taksanlar.
DE60104281T DE60104281T2 (de)	2000-01-18	2001-01-15	Semi-synthetische taxane mit antitumor und antiangiogenetischer wirkung
PCT/EP2001/000386 WO2001053282A1 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
ES01905668T ES2223778T3 (es)	2000-01-18	2001-01-15	Taxanos semisinteticos con actividad antitumoral y antiangiogenica.
HU0204344A HU229347B1 (hu)	2000-01-18	2001-01-15	Daganatellenes és érképzõdés-ellenes hatású félszintetikus taxánok, valamint ezeket tartalmazó gyógyászati készítmények
DK01905668T DK1248776T3 (da)	2000-01-18	2001-01-15	Semi-syntetiske taxaner med antitumor og antiangiogene aktiviteter
SI200130147T SI1248776T1 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
JP2001553757A JP4986354B2 (ja)	2000-01-18	2001-01-15	抗腫瘍活性及び抗脈管形成活性を有する半合成タキサン類
CZ20022478A CZ301251B6 (cs)	2000-01-18	2001-01-15	Polosyntetické taxany s antitumorovými a antiangiogenními úcinky a jejich použití pro výrobu farmaceutického prostredku
AU33694/01A AU781650B2 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
RU2002119060/04A RU2259363C2 (ru)	2000-01-18	2001-01-15	Полусинтетические таксаны и фармацевтические композиции на их основе
SK1056-2002A SK285683B6 (sk)	2000-01-18	2001-01-15	Polosyntetické taxány, farmaceutický prostriedok s ich obsahom a ich použitie
PL356272A PL202591B1 (pl)	2000-01-18	2001-01-15	Związki stanowiace pochodne seco-bakkatyny, kompozycje farmaceutyczne zawierające te związki i zastosowanie tych związków do wytwarzania leków o działaniu przeciwnowotworowym i przeciwnaczyniotwórczym
CNB018038344A CN1176916C (zh)	2000-01-18	2001-01-15	具有抗肿瘤和抗血管生成活性的半合成紫杉烷
KR1020027009182A KR100813704B1 (ko)	2000-01-18	2001-01-15	항암활성 및 혈관신생억제활성을 가진 반합성 탁산
EP01905668A EP1248776B1 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
US10/187,995 US6589979B2 (en)	2000-01-18	2002-07-03	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
NO20023428A NO329403B1 (no)	2000-01-18	2002-07-17	Semisyntetiske taksaner med antitumor, antiangiogenetiske og anti-artrose aktiviteter, farmasoytiske sammensetninger inneholdende dem og anvendelse av forbindelsene
HK03102021.6A HK1049998B (zh)	2000-01-18	2003-03-19	具有抗腫瘤和抗血管生成活性的半合成紫杉烷
US11/158,323 USRE39723E1 (en)	2000-01-18	2005-06-20	Semi-synthetic taxanes with antitumor and antiangiogenetic activities

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000MI000056A IT1317731B1 (it)	2000-01-18	2000-01-18	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.

Publications (3)

Publication Number	Publication Date
ITMI20000056A0 ITMI20000056A0 (it)	2000-01-18
ITMI20000056A1 ITMI20000056A1 (it)	2001-07-18
IT1317731B1 true IT1317731B1 (it)	2003-07-15

Family

ID=11443708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2000MI000056A IT1317731B1 (it)	2000-01-18	2000-01-18	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.

Country Status (24)

Country	Link
US (2)	US6589979B2 (it)
EP (1)	EP1248776B1 (it)
JP (1)	JP4986354B2 (it)
KR (1)	KR100813704B1 (it)
CN (1)	CN1176916C (it)
AT (1)	ATE271044T1 (it)
AU (1)	AU781650B2 (it)
CA (1)	CA2397591C (it)
CZ (1)	CZ301251B6 (it)
DE (1)	DE60104281T2 (it)
DK (1)	DK1248776T3 (it)
ES (1)	ES2223778T3 (it)
HK (1)	HK1049998B (it)
HU (1)	HU229347B1 (it)
IL (1)	IL150787A0 (it)
IT (1)	IT1317731B1 (it)
NO (1)	NO329403B1 (it)
PL (1)	PL202591B1 (it)
PT (1)	PT1248776E (it)
RU (1)	RU2259363C2 (it)
SI (1)	SI1248776T1 (it)
SK (1)	SK285683B6 (it)
TR (1)	TR200401811T4 (it)
WO (1)	WO2001053282A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1688415A1 (en) *	2004-12-07	2006-08-09	Aventis Pharma S.A.	Cytotoxic agents comprising new C-2 modified taxanes
ITMI20050415A1 (it) *	2005-03-15	2006-09-16	Indena Spa	Derivati tassanici semi-sintetici ad attivita' antitumorale
EP2922818B1 (en)	2012-11-24	2018-09-05	Hangzhou Dac Biotech Co., Ltd	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
FI3122757T3 (fi)	2014-02-28	2023-10-10	Hangzhou Dac Biotech Co Ltd	Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
JP6759326B2 (ja)	2015-07-12	2020-09-23	ハンジョウディーエーシーバイオテックシーオー．，エルティディ．ＨａｎｇｚｈｏｕＤａｃＢｉｏｔｅｃｈＣｏ．，Ｌｔｄ．	細胞結合分子の共役のための架橋連結体
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en)	2016-11-14	2019-05-02	Hangzhou Dac Biotech Co., Ltd.	Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
CA2109861C (en) *	1992-12-04	1999-03-16	Shu-Hui Chen	6,7-modified paclitaxels
DE69507702T2 (de) *	1994-07-26	1999-08-26	Indena S.P.A.	Semisynthetisch taxal derivate mit antitumor wirkung

2000
- 2000-01-18 IT IT2000MI000056A patent/IT1317731B1/it active
2001
- 2001-01-15 PL PL356272A patent/PL202591B1/pl unknown
- 2001-01-15 EP EP01905668A patent/EP1248776B1/en not_active Expired - Lifetime
- 2001-01-15 KR KR1020027009182A patent/KR100813704B1/ko active IP Right Grant
- 2001-01-15 RU RU2002119060/04A patent/RU2259363C2/ru not_active IP Right Cessation
- 2001-01-15 AU AU33694/01A patent/AU781650B2/en not_active Ceased
- 2001-01-15 PT PT01905668T patent/PT1248776E/pt unknown
- 2001-01-15 AT AT01905668T patent/ATE271044T1/de active
- 2001-01-15 JP JP2001553757A patent/JP4986354B2/ja not_active Expired - Fee Related
- 2001-01-15 HU HU0204344A patent/HU229347B1/hu not_active IP Right Cessation
- 2001-01-15 DE DE60104281T patent/DE60104281T2/de not_active Expired - Lifetime
- 2001-01-15 SI SI200130147T patent/SI1248776T1/xx unknown
- 2001-01-15 TR TR2004/01811T patent/TR200401811T4/xx unknown
- 2001-01-15 IL IL15078701A patent/IL150787A0/xx active IP Right Grant
- 2001-01-15 CZ CZ20022478A patent/CZ301251B6/cs not_active IP Right Cessation
- 2001-01-15 CA CA002397591A patent/CA2397591C/en not_active Expired - Lifetime
- 2001-01-15 DK DK01905668T patent/DK1248776T3/da active
- 2001-01-15 SK SK1056-2002A patent/SK285683B6/sk not_active IP Right Cessation
- 2001-01-15 ES ES01905668T patent/ES2223778T3/es not_active Expired - Lifetime
- 2001-01-15 CN CNB018038344A patent/CN1176916C/zh not_active Expired - Fee Related
- 2001-01-15 WO PCT/EP2001/000386 patent/WO2001053282A1/en active IP Right Grant
2002
- 2002-07-03 US US10/187,995 patent/US6589979B2/en not_active Ceased
- 2002-07-17 NO NO20023428A patent/NO329403B1/no not_active IP Right Cessation
2003
- 2003-03-19 HK HK03102021.6A patent/HK1049998B/zh not_active IP Right Cessation
2005
- 2005-06-20 US US11/158,323 patent/USRE39723E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO329403B1 (no)	2010-10-11
KR100813704B1 (ko)	2008-03-13
ES2223778T3 (es)	2005-03-01
PL202591B1 (pl)	2009-07-31
SI1248776T1 (en)	2004-10-31
CZ20022478A3 (cs)	2002-10-16
RU2259363C2 (ru)	2005-08-27
CN1176916C (zh)	2004-11-24
US20030028038A1 (en)	2003-02-06
TR200401811T4 (tr)	2004-09-21
AU3369401A (en)	2001-07-31
NO20023428L (no)	2002-09-16
WO2001053282A1 (en)	2001-07-26
NO20023428D0 (no)	2002-07-17
US6589979B2 (en)	2003-07-08
AU781650B2 (en)	2005-06-02
ITMI20000056A1 (it)	2001-07-18
SK285683B6 (sk)	2007-06-07
JP4986354B2 (ja)	2012-07-25
DE60104281D1 (de)	2004-08-19
DK1248776T3 (da)	2004-11-22
HK1049998B (zh)	2005-04-01
JP2003520792A (ja)	2003-07-08
EP1248776A1 (en)	2002-10-16
HUP0204344A3 (en)	2004-01-28
HK1049998A1 (en)	2003-06-06
PL356272A1 (en)	2004-06-28
CZ301251B6 (cs)	2009-12-23
EP1248776B1 (en)	2004-07-14
PT1248776E (pt)	2004-10-29
CA2397591C (en)	2009-10-20
HU229347B1 (hu)	2013-11-28
DE60104281T2 (de)	2005-08-18
SK10562002A3 (sk)	2002-11-06
ITMI20000056A0 (it)	2000-01-18
IL150787A0 (en)	2003-02-12
HUP0204344A2 (en)	2003-05-28
CN1395571A (zh)	2003-02-05
RU2002119060A (ru)	2004-01-10
CA2397591A1 (en)	2001-07-26
KR20020068082A (ko)	2002-08-24
ATE271044T1 (de)	2004-07-15
USRE39723E1 (en)	2007-07-10

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SE9902267D0 (sv)	1999-06-16	New compounds
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