DK1248776T3 - Semi-syntetiske taxaner med antitumor og antiangiogene aktiviteter - Google Patents

Semi-syntetiske taxaner med antitumor og antiangiogene aktiviteter

Info

Publication number: DK1248776T3
Authority: DK; Denmark
Prior art keywords: del; ins; sup; delete; date
Prior art date: 2000-01-18

Application number

DK01905668T

Other languages

English (en)

Inventor

Ezio Bombardelli

Alessandro Pontiroli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-18

Filing date

2001-01-15

Publication date

2004-11-22

2001-01-15 Application filed by Indena Spa filed Critical Indena Spa

2004-11-22 Application granted granted Critical

2004-11-22 Publication of DK1248776T3 publication Critical patent/DK1248776T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Oncology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK01905668T 2000-01-18 2001-01-15 Semi-syntetiske taxaner med antitumor og antiangiogene aktiviteter DK1248776T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI000056A IT1317731B1 (it)	2000-01-18	2000-01-18	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
EP01905668A EP1248776B1 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities

Publications (1)

Publication Number	Publication Date
DK1248776T3 true DK1248776T3 (da)	2004-11-22

Family

ID=11443708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01905668T DK1248776T3 (da)	2000-01-18	2001-01-15	Semi-syntetiske taxaner med antitumor og antiangiogene aktiviteter

Country Status (24)

Country	Link
US (2)	US6589979B2 (da)
EP (1)	EP1248776B1 (da)
JP (1)	JP4986354B2 (da)
KR (1)	KR100813704B1 (da)
CN (1)	CN1176916C (da)
AT (1)	ATE271044T1 (da)
AU (1)	AU781650B2 (da)
CA (1)	CA2397591C (da)
CZ (1)	CZ301251B6 (da)
DE (1)	DE60104281T2 (da)
DK (1)	DK1248776T3 (da)
ES (1)	ES2223778T3 (da)
HK (1)	HK1049998B (da)
HU (1)	HU229347B1 (da)
IL (1)	IL150787A0 (da)
IT (1)	IT1317731B1 (da)
NO (1)	NO329403B1 (da)
PL (1)	PL202591B1 (da)
PT (1)	PT1248776E (da)
RU (1)	RU2259363C2 (da)
SI (1)	SI1248776T1 (da)
SK (1)	SK285683B6 (da)
TR (1)	TR200401811T4 (da)
WO (1)	WO2001053282A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1688415A1 (en) *	2004-12-07	2006-08-09	Aventis Pharma S.A.	Cytotoxic agents comprising new C-2 modified taxanes
ITMI20050415A1 (it) *	2005-03-15	2006-09-16	Indena Spa	Derivati tassanici semi-sintetici ad attivita' antitumorale
EP2922818B1 (en)	2012-11-24	2018-09-05	Hangzhou Dac Biotech Co., Ltd	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
DK3122757T3 (da)	2014-02-28	2023-10-09	Hangzhou Dac Biotech Co Ltd	Ladede linkere og anvendelse deraf til konjugering
CN113350518A (zh)	2015-07-12	2021-09-07	杭州多禧生物科技有限公司	与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
EP3888691A1 (en)	2016-11-14	2021-10-06	Hangzhou Dac Biotech Co., Ltd.	Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
CA2109861C (en) *	1992-12-04	1999-03-16	Shu-Hui Chen	6,7-modified paclitaxels
EP0773938B1 (en)	1994-07-26	1999-02-03	INDENA S.p.A.	Semi-synthetic taxanes with anti-tumoural activity

2000
- 2000-01-18 IT IT2000MI000056A patent/IT1317731B1/it active
2001
- 2001-01-15 DK DK01905668T patent/DK1248776T3/da active
- 2001-01-15 CZ CZ20022478A patent/CZ301251B6/cs not_active IP Right Cessation
- 2001-01-15 EP EP01905668A patent/EP1248776B1/en not_active Expired - Lifetime
- 2001-01-15 HU HU0204344A patent/HU229347B1/hu not_active IP Right Cessation
- 2001-01-15 SI SI200130147T patent/SI1248776T1/xx unknown
- 2001-01-15 SK SK1056-2002A patent/SK285683B6/sk not_active IP Right Cessation
- 2001-01-15 AT AT01905668T patent/ATE271044T1/de active
- 2001-01-15 DE DE60104281T patent/DE60104281T2/de not_active Expired - Lifetime
- 2001-01-15 WO PCT/EP2001/000386 patent/WO2001053282A1/en active IP Right Grant
- 2001-01-15 CA CA002397591A patent/CA2397591C/en not_active Expired - Lifetime
- 2001-01-15 ES ES01905668T patent/ES2223778T3/es not_active Expired - Lifetime
- 2001-01-15 PL PL356272A patent/PL202591B1/pl unknown
- 2001-01-15 CN CNB018038344A patent/CN1176916C/zh not_active Expired - Fee Related
- 2001-01-15 KR KR1020027009182A patent/KR100813704B1/ko active IP Right Grant
- 2001-01-15 RU RU2002119060/04A patent/RU2259363C2/ru not_active IP Right Cessation
- 2001-01-15 PT PT01905668T patent/PT1248776E/pt unknown
- 2001-01-15 TR TR2004/01811T patent/TR200401811T4/xx unknown
- 2001-01-15 JP JP2001553757A patent/JP4986354B2/ja not_active Expired - Fee Related
- 2001-01-15 AU AU33694/01A patent/AU781650B2/en not_active Ceased
- 2001-01-15 IL IL15078701A patent/IL150787A0/xx active IP Right Grant
2002
- 2002-07-03 US US10/187,995 patent/US6589979B2/en not_active Ceased
- 2002-07-17 NO NO20023428A patent/NO329403B1/no not_active IP Right Cessation
2003
- 2003-03-19 HK HK03102021.6A patent/HK1049998B/zh not_active IP Right Cessation
2005
- 2005-06-20 US US11/158,323 patent/USRE39723E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ITMI20000056A0 (it)	2000-01-18
JP4986354B2 (ja)	2012-07-25
NO329403B1 (no)	2010-10-11
AU3369401A (en)	2001-07-31
CA2397591A1 (en)	2001-07-26
IL150787A0 (en)	2003-02-12
SK285683B6 (sk)	2007-06-07
CA2397591C (en)	2009-10-20
NO20023428L (no)	2002-09-16
HU229347B1 (hu)	2013-11-28
CZ301251B6 (cs)	2009-12-23
HK1049998B (zh)	2005-04-01
HUP0204344A2 (en)	2003-05-28
HK1049998A1 (en)	2003-06-06
ITMI20000056A1 (it)	2001-07-18
ATE271044T1 (de)	2004-07-15
HUP0204344A3 (en)	2004-01-28
CN1395571A (zh)	2003-02-05
CZ20022478A3 (cs)	2002-10-16
IT1317731B1 (it)	2003-07-15
DE60104281D1 (de)	2004-08-19
US20030028038A1 (en)	2003-02-06
KR20020068082A (ko)	2002-08-24
ES2223778T3 (es)	2005-03-01
USRE39723E1 (en)	2007-07-10
SI1248776T1 (en)	2004-10-31
DE60104281T2 (de)	2005-08-18
JP2003520792A (ja)	2003-07-08
PL356272A1 (en)	2004-06-28
SK10562002A3 (sk)	2002-11-06
EP1248776B1 (en)	2004-07-14
EP1248776A1 (en)	2002-10-16
WO2001053282A1 (en)	2001-07-26
AU781650B2 (en)	2005-06-02
NO20023428D0 (no)	2002-07-17
CN1176916C (zh)	2004-11-24
KR100813704B1 (ko)	2008-03-13
PT1248776E (pt)	2004-10-29
PL202591B1 (pl)	2009-07-31
TR200401811T4 (tr)	2004-09-21
RU2002119060A (ru)	2004-01-10
US6589979B2 (en)	2003-07-08
RU2259363C2 (ru)	2005-08-27

Publication	Publication Date	Title
RU2365372C2 (ru)	2009-08-27	Циклические ингибиторы протеинтирозинкиназ
DE60318177D1 (de)	2008-01-31	Rho-kinase inhibitoren
TR200200717T2 (tr)	2002-06-21	Terapötik kinazolin türevleri.
ATE453636T1 (de)	2010-01-15	Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren
HK1097189A1 (en)	2007-06-22	Cannabinoid receptor ligands
MY134783A (en)	2007-12-31	Rho-kinase inhibitors
MY142915A (en)	2011-01-31	Rho-kinase inhibitors
BR0010746A (pt)	2002-02-13	Derivados heterocìclicos úteis com agentes anticâncer
IS6865A (is)	2003-07-03	Setnar alkýlamínafleiður og aðferðir við notkun þeirra
DK1309589T3 (da)	2006-06-12	Ureaforbindelser og anvendelsesfremgangsmåder
PT1017675E (pt)	2006-09-29	Derivados da camtotecina altamente lipofilos
NO20021367D0 (no)	2002-03-19	Indolyl-3-glyoksylsyrederivater som har terapeutisk verdifulle egenskaper
PT1212312E (pt)	2003-08-29	Novos derivados de flavonas xantonas e cumarinas
ATE238981T1 (de)	2003-05-15	Antitumorwirkstoffe
NO20024076D0 (no)	2002-08-27	Sammensetning omfattende camptotecin og et pyrimidinderivat for behandling av cancer
DK1248776T3 (da)	2004-11-22	Semi-syntetiske taxaner med antitumor og antiangiogene aktiviteter
DK1039900T3 (da)	2004-10-04	Farmaceutisk præparat indeholdende sibutramin og orlistat
ATE390923T1 (de)	2008-04-15	Topoisomerase-giftmittel
NO20031410D0 (no)	2003-03-27	Antitumorterapi innbefattende distamycinderivater
DK1549329T3 (da)	2007-05-07	Ekstrakt med antitumoraktivitet og anti-giftaktivitet
EE200200660A (et)	2004-06-15	Akrüloüüldistamütsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritudravimpreparaat
FR2908131B1 (fr)	2009-01-09	Derives d'aminobenzocycloheptene,leurs procedes de preparation et leur utilisation en therapeutique
RS20220367A1 (sr)	2023-10-31	Derivati diazahrizenа, njihovo dobijanje i primena
Su et al.	2006	Antitumor therapeutic effects of new gene-targeted alkylating agents, 9-anilinoacridines bearing an alkylating N-mustard residue on the acridine chromophore
DK1551850T3 (da)	2006-09-25	2"-oxo-voruscharin og derivater deraf