SI1248776T1 - Semi-synthetic taxanes with antitumor and antiangiogenetic activities - Google Patents

Semi-synthetic taxanes with antitumor and antiangiogenetic activities

Info

Publication number: SI1248776T1
Authority: SI; Slovenia
Prior art keywords: del; ins; sup; delete; date
Prior art date: 2000-01-18

Application number

SI200130147T

Other languages

English (en)

Slovenian (sl)

Inventor

Ezio Bombardelli

Alessandro Pontiroli

Original Assignee

Indena S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-18

Filing date

2001-01-15

Publication date

2004-10-31

2001-01-15 Application filed by Indena S.P.A. filed Critical Indena S.P.A.

2004-10-31 Publication of SI1248776T1 publication Critical patent/SI1248776T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Oncology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SI200130147T 2000-01-18 2001-01-15 Semi-synthetic taxanes with antitumor and antiangiogenetic activities SI1248776T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT2000MI000056A IT1317731B1 (it)	2000-01-18	2000-01-18	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
EP01905668A EP1248776B1 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
PCT/EP2001/000386 WO2001053282A1 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities

Publications (1)

Publication Number	Publication Date
SI1248776T1 true SI1248776T1 (en)	2004-10-31

Family

ID=11443708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200130147T SI1248776T1 (en)	2000-01-18	2001-01-15	Semi-synthetic taxanes with antitumor and antiangiogenetic activities

Country Status (24)

Country	Link
US (2)	US6589979B2 (da)
EP (1)	EP1248776B1 (da)
JP (1)	JP4986354B2 (da)
KR (1)	KR100813704B1 (da)
CN (1)	CN1176916C (da)
AT (1)	ATE271044T1 (da)
AU (1)	AU781650B2 (da)
CA (1)	CA2397591C (da)
CZ (1)	CZ301251B6 (da)
DE (1)	DE60104281T2 (da)
DK (1)	DK1248776T3 (da)
ES (1)	ES2223778T3 (da)
HK (1)	HK1049998B (da)
HU (1)	HU229347B1 (da)
IL (1)	IL150787A0 (da)
IT (1)	IT1317731B1 (da)
NO (1)	NO329403B1 (da)
PL (1)	PL202591B1 (da)
PT (1)	PT1248776E (da)
RU (1)	RU2259363C2 (da)
SI (1)	SI1248776T1 (da)
SK (1)	SK285683B6 (da)
TR (1)	TR200401811T4 (da)
WO (1)	WO2001053282A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1688415A1 (en) *	2004-12-07	2006-08-09	Aventis Pharma S.A.	Cytotoxic agents comprising new C-2 modified taxanes
ITMI20050415A1 (it) *	2005-03-15	2006-09-16	Indena Spa	Derivati tassanici semi-sintetici ad attivita' antitumorale
EP2922818B1 (en)	2012-11-24	2018-09-05	Hangzhou Dac Biotech Co., Ltd	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
EP3122757B1 (en)	2014-02-28	2023-09-06	Hangzhou Dac Biotech Co., Ltd	Charged linkers and their uses for conjugation
JP6759326B2 (ja)	2015-07-12	2020-09-23	ハンジョウディーエーシーバイオテックシーオー．，エルティディ．ＨａｎｇｚｈｏｕＤａｃＢｉｏｔｅｃｈＣｏ．，Ｌｔｄ．	細胞結合分子の共役のための架橋連結体
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en)	2016-11-14	2019-05-02	Hangzhou Dac Biotech Co., Ltd.	Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
CA2109861C (en) *	1992-12-04	1999-03-16	Shu-Hui Chen	6,7-modified paclitaxels
SI9520078B (sl)	1994-07-26	1998-12-31	Indena S.P.A.	Polsintetski taksani z antitumorsko aktivnostjo

2000
- 2000-01-18 IT IT2000MI000056A patent/IT1317731B1/it active
2001
- 2001-01-15 PT PT01905668T patent/PT1248776E/pt unknown
- 2001-01-15 ES ES01905668T patent/ES2223778T3/es not_active Expired - Lifetime
- 2001-01-15 AT AT01905668T patent/ATE271044T1/de active
- 2001-01-15 DE DE60104281T patent/DE60104281T2/de not_active Expired - Lifetime
- 2001-01-15 CA CA002397591A patent/CA2397591C/en not_active Expired - Lifetime
- 2001-01-15 DK DK01905668T patent/DK1248776T3/da active
- 2001-01-15 SK SK1056-2002A patent/SK285683B6/sk not_active IP Right Cessation
- 2001-01-15 EP EP01905668A patent/EP1248776B1/en not_active Expired - Lifetime
- 2001-01-15 SI SI200130147T patent/SI1248776T1/xx unknown
- 2001-01-15 RU RU2002119060/04A patent/RU2259363C2/ru not_active IP Right Cessation
- 2001-01-15 AU AU33694/01A patent/AU781650B2/en not_active Ceased
- 2001-01-15 PL PL356272A patent/PL202591B1/pl unknown
- 2001-01-15 CZ CZ20022478A patent/CZ301251B6/cs not_active IP Right Cessation
- 2001-01-15 TR TR2004/01811T patent/TR200401811T4/xx unknown
- 2001-01-15 WO PCT/EP2001/000386 patent/WO2001053282A1/en active IP Right Grant
- 2001-01-15 JP JP2001553757A patent/JP4986354B2/ja not_active Expired - Fee Related
- 2001-01-15 CN CNB018038344A patent/CN1176916C/zh not_active Expired - Fee Related
- 2001-01-15 HU HU0204344A patent/HU229347B1/hu not_active IP Right Cessation
- 2001-01-15 KR KR1020027009182A patent/KR100813704B1/ko active IP Right Grant
- 2001-01-15 IL IL15078701A patent/IL150787A0/xx active IP Right Grant
2002
- 2002-07-03 US US10/187,995 patent/US6589979B2/en not_active Ceased
- 2002-07-17 NO NO20023428A patent/NO329403B1/no not_active IP Right Cessation
2003
- 2003-03-19 HK HK03102021.6A patent/HK1049998B/zh not_active IP Right Cessation
2005
- 2005-06-20 US US11/158,323 patent/USRE39723E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ITMI20000056A1 (it)	2001-07-18
CA2397591A1 (en)	2001-07-26
RU2002119060A (ru)	2004-01-10
HK1049998B (zh)	2005-04-01
NO20023428D0 (no)	2002-07-17
NO20023428L (no)	2002-09-16
JP2003520792A (ja)	2003-07-08
US6589979B2 (en)	2003-07-08
HK1049998A1 (en)	2003-06-06
CN1395571A (zh)	2003-02-05
PL202591B1 (pl)	2009-07-31
CA2397591C (en)	2009-10-20
SK285683B6 (sk)	2007-06-07
CZ301251B6 (cs)	2009-12-23
EP1248776B1 (en)	2004-07-14
AU3369401A (en)	2001-07-31
KR20020068082A (ko)	2002-08-24
NO329403B1 (no)	2010-10-11
HUP0204344A3 (en)	2004-01-28
SK10562002A3 (sk)	2002-11-06
ATE271044T1 (de)	2004-07-15
AU781650B2 (en)	2005-06-02
ITMI20000056A0 (it)	2000-01-18
CZ20022478A3 (cs)	2002-10-16
JP4986354B2 (ja)	2012-07-25
HU229347B1 (hu)	2013-11-28
EP1248776A1 (en)	2002-10-16
DE60104281T2 (de)	2005-08-18
PL356272A1 (en)	2004-06-28
TR200401811T4 (tr)	2004-09-21
PT1248776E (pt)	2004-10-29
HUP0204344A2 (en)	2003-05-28
WO2001053282A1 (en)	2001-07-26
ES2223778T3 (es)	2005-03-01
IL150787A0 (en)	2003-02-12
CN1176916C (zh)	2004-11-24
DK1248776T3 (da)	2004-11-22
KR100813704B1 (ko)	2008-03-13
RU2259363C2 (ru)	2005-08-27
USRE39723E1 (en)	2007-07-10
DE60104281D1 (de)	2004-08-19
US20030028038A1 (en)	2003-02-06
IT1317731B1 (it)	2003-07-15

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TR200200717T2 (tr)	2002-06-21	Terapötik kinazolin türevleri.
EA200000282A1 (ru)	2000-10-30	Способ введения таксана пациенту, нуждающемуся в лечении таксаном, способ лечения человека таксаном (варианты)
EP1154782A4 (en)	2002-09-25	TAXAN DERIVATIVES FOR TARGETED CANCER THERAPY
GB2334521A (en)	1999-08-25	Anthranilic acid derivatives as multi drug resistance modulators
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BR0010746A (pt)	2002-02-13	Derivados heterocìclicos úteis com agentes anticâncer
PL367682A1 (en)	2005-03-07	Dolastatin 10 derivatives
PL364811A1 (en)	2004-12-13	Indolyl-3-glyoxylic acid derivatives serving as antitumor agents
EP1017675A4 (en)	2001-08-22	HIGHLY LIPOPHILIC CAMPTOTHECIN DERIVATIVES
PT1212312E (pt)	2003-08-29	Novos derivados de flavonas xantonas e cumarinas
BG104436A (en)	2000-12-29	The administration of macrolides for the treatment of cancer and macular degeneration
ATE238981T1 (de)	2003-05-15	Antitumorwirkstoffe
ATE268174T1 (de)	2004-06-15	Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen
IL150787A0 (en)	2003-02-12	Semi-synthetic taxanes with antitumor and antiangiogenetic activities
NO20031410D0 (no)	2003-03-27	Antitumorterapi innbefattende distamycinderivater
MX2007001267A (es)	2007-07-11	Derivados de naftiridinas 2,8-disustituidas.
EE200200681A (et)	2004-06-15	Akrüloüüldistamütsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritudravimpreparaat
MXPA01012936A (es)	2004-04-21	Composicion farmaceutica que contiene sibutramina y orlistat.
NZ337048A (en)	2000-10-27	Use of N-[1-methyl-(substituted phenyl)ethyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide derivatives to treat prostate cancer
Su et al.	2006	Antitumor therapeutic effects of new gene-targeted alkylating agents, 9-anilinoacridines bearing an alkylating N-mustard residue on the acridine chromophore