[go: up one dir, main page]

SI9300513B - Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni - Google Patents

Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni Download PDF

Info

Publication number
SI9300513B
SI9300513B SI9300513A SI9300513A SI9300513B SI 9300513 B SI9300513 B SI 9300513B SI 9300513 A SI9300513 A SI 9300513A SI 9300513 A SI9300513 A SI 9300513A SI 9300513 B SI9300513 B SI 9300513B
Authority
SI
Slovenia
Prior art keywords
carbon atoms
group
phenyl
alkyl
formula
Prior art date
Application number
SI9300513A
Other languages
English (en)
Slovenian (sl)
Other versions
SI9300513A (en
Inventor
Xavier Edmonds-Alt
Patrick Gueule
Vincenzo Proietto
Broeck Didier Van
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of SI9300513A publication Critical patent/SI9300513A/sl
Publication of SI9300513B publication Critical patent/SI9300513B/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
SI9300513A 1992-09-30 1993-09-30 Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni SI9300513B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9212083A FR2696178B1 (fr) 1992-09-30 1992-09-30 Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.

Publications (2)

Publication Number Publication Date
SI9300513A SI9300513A (en) 1994-06-30
SI9300513B true SI9300513B (sl) 2002-02-28

Family

ID=9434374

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9300513A SI9300513B (sl) 1992-09-30 1993-09-30 Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni

Country Status (27)

Country Link
EP (1) EP0591040B1 (cs)
JP (2) JP2857041B2 (cs)
KR (1) KR100279084B1 (cs)
CN (1) CN1036652C (cs)
AT (1) ATE176469T1 (cs)
AU (1) AU674875B2 (cs)
BR (1) BR9303982A (cs)
CA (1) CA2107432C (cs)
CZ (1) CZ287272B6 (cs)
DE (1) DE69323375T2 (cs)
DK (1) DK0591040T3 (cs)
ES (1) ES2130238T3 (cs)
FI (1) FI114474B (cs)
FR (1) FR2696178B1 (cs)
GR (1) GR3030000T3 (cs)
HU (2) HU215848B (cs)
IL (1) IL107158A0 (cs)
MX (1) MX9306024A (cs)
MY (1) MY108881A (cs)
NO (1) NO304888B1 (cs)
NZ (1) NZ248821A (cs)
OA (1) OA09869A (cs)
RU (1) RU2120436C1 (cs)
SG (1) SG47807A1 (cs)
SI (1) SI9300513B (cs)
TW (1) TW242625B (cs)
ZA (1) ZA937276B (cs)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583134A (en) * 1992-09-30 1996-12-10 Sanofi 1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
FR2717804B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Sels de composés hétéroaromatiques azotés substitués, procédé pour leur préparation et compositions pharmaceutiques en contenant.
FR2717802B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant.
IL113472A0 (en) 1994-04-29 1995-07-31 Lilly Co Eli Non-peptidyl tachykinin receptor antogonists
AU688072B2 (en) 1994-07-12 1998-03-05 Eli Lilly And Company Heterocyclic tachykinin receptor antagonists
FR2725900B1 (fr) * 1994-10-21 1997-07-18 Sanofi Sa Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9421709D0 (en) * 1994-10-27 1994-12-14 Zeneca Ltd Therapeutic compounds
EP0714891A1 (en) * 1994-11-22 1996-06-05 Eli Lilly And Company Heterocyclic tachykinin receptor antagonists
FR2751654B1 (fr) * 1996-07-26 1998-10-23 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729952B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729951B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
EP0848706B1 (en) * 1995-06-06 2003-02-05 Schering Corporation Substituted benzene-fused heterocyclics as neurokinin antagonists
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
FR2745811B1 (fr) 1996-03-07 1998-05-22 Sanofi Sa Glutarimide disubstitue procede pour sa preparation, et son utilisation
AU3149297A (en) * 1996-05-24 1997-12-09 Eli Lilly And Company Methods of treating hypertension
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
GB9617730D0 (en) * 1996-08-23 1996-10-02 Pfizer Ltd Quarternary ammonium compounds
FR2759584B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire
FR2759585B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique
WO1998047513A1 (en) * 1997-04-24 1998-10-29 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating eating disorders
GB9712882D0 (en) * 1997-06-18 1997-08-20 Pfizer Ltd Quaternary ammonium compounds
GB9716463D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
CA2298777A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating mania
GB9716457D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
CA2298779A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
GB9927125D0 (en) 1999-11-16 2000-01-12 Univ Reading The Placental human neurokinin B precursor
US7560549B2 (en) 2004-02-25 2009-07-14 Sankyo Company, Limited Sulfonyloxy derivatives
CA2601709C (en) 2005-03-22 2017-02-14 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids
RU2466991C2 (ru) 2005-07-19 2012-11-20 Эйзеван Фармасьютиклз, Инк. β-ЛАКТАМИЛЗАМЕЩЕННЫЕ АНАЛОГИ ФЕНИЛАЛАНИНА, ЦИСТЕИНА И СЕРИНА В КАЧЕСТВЕ АНТАГОНИСТОВ ВАЗОПРЕССИНА
JP2010516731A (ja) 2007-01-24 2010-05-20 グラクソ グループ リミテッド ２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
ES2858499T3 (es) 2010-07-01 2021-09-30 Azevan Pharmaceuticals Inc Compuestos para su uso en el tratamiento de trastorno explosivo intermitente
EP3122743B1 (en) 2014-03-28 2022-11-09 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
EP3556435B1 (en) * 2016-12-14 2020-10-28 Beijing Showby Pharmaceutical Co., Ltd. Class of bifunctional compounds with quaternary ammonium salt structure
AU2018333051B2 (en) 2017-09-15 2024-03-21 Azevan Pharmaceuticals, Inc. Compositions and methods for treating brain injury

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2666185B1 (fr) * 1990-08-21 1992-12-04 Sgs Thomson Microelectronics Convertisseur analogique/numerique a interpolation.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
HU9302770D0 (en) 1993-12-28
SG47807A1 (en) 1998-04-17
NO304888B1 (no) 1999-03-01
DK0591040T3 (da) 1999-09-20
JPH10175976A (ja) 1998-06-30
AU674875B2 (en) 1997-01-16
CZ203593A3 (en) 1994-04-13
DE69323375T2 (de) 1999-06-24
HU215848B (hu) 1999-04-28
CN1088582A (zh) 1994-06-29
FR2696178A1 (fr) 1994-04-01
NO933481D0 (no) 1993-09-29
JP3243212B2 (ja) 2002-01-07
JP2857041B2 (ja) 1999-02-10
TW242625B (cs) 1995-03-11
CA2107432C (en) 2000-04-04
CA2107432A1 (en) 1994-03-31
HU211889A9 (en) 1995-12-28
FR2696178B1 (fr) 1994-12-30
ES2130238T3 (es) 1999-07-01
IL107158A0 (en) 1993-12-28
ZA937276B (en) 1994-04-25
BR9303982A (pt) 1994-10-25
NZ248821A (en) 1995-10-26
MY108881A (en) 1996-11-30
FI934273A (fi) 1994-03-31
FI114474B (fi) 2004-10-29
KR940007026A (ko) 1994-04-26
CN1036652C (zh) 1997-12-10
GR3030000T3 (en) 1999-07-30
CZ287272B6 (en) 2000-10-11
NO933481L (no) 1994-04-05
EP0591040A1 (fr) 1994-04-06
FI934273A0 (fi) 1993-09-29
OA09869A (fr) 1994-08-15
DE69323375D1 (de) 1999-03-18
EP0591040B1 (fr) 1999-02-03
KR100279084B1 (ko) 2001-01-15
HUT65759A (en) 1994-07-28
JPH06211850A (ja) 1994-08-02
SI9300513A (en) 1994-06-30
MX9306024A (es) 1994-03-31
AU4870893A (en) 1994-04-14
ATE176469T1 (de) 1999-02-15
RU2120436C1 (ru) 1998-10-20

Similar Documents

Publication Publication Date Title
SI9300513B (sl) Kvarterni bazični amidi, postopek za njihovo pripravo in farmacevtski sestavki, v katerih so prisotni
KR930703025A (ko) 비사이클로폴리아자매크로사이클로포스폰산 착체, 그의 제조방법, 결합체 및 방사성 약제
ES2212580T3 (es) Inhibidores de la proteina farnesil-transferasa para el tratamiento de artropatias.
BRPI0017548B8 (pt) Composto
FR2903107B1 (fr) Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
EA200600497A1 (ru) Композиция для аэрозольной ингаляции, содержащая антихолинергическое средство
CA2111560A1 (en) Stable pharmaceutical composition of fumagillol derivatives
AR012488A1 (es) Un compuesto derivado de quino- y quinazolinas antagonistas del factor liberador de corticotropina, un procedimiento para su preparacion, unacomposicion que los comprende, un procedimiento para la preparacion de dicha composicion, intermediarios y el uso de dichos compuestos para la fabricacion
JP2002521428A5 (cs)
MX2007001855A (es) Solucion para infusion de dihidropteridinonas que tiene una larga vida en el estante.
RU93055131A (ru) Четвертичные амиды основного характера, способ их получения и содержащая их фармацевтическая композиция
RU2005121162A (ru) Производные хинуклидина, фармацевтическая композиция и способ лечения респираторных, урологических или желудочно-кишечных заболеваний
SI9620111B (en) Imidazole derivatives having affinity for alpha2 receptors activity
JP2004509128A5 (cs)
HRP20120394T1 (hr) Derivati karbonata kinuklodina i njihovi medicinski pripravci
HRP20110178T1 (hr) Kinuklidinski derivati (hetero) arilcikloheptankarboksilne kiseline kao antagonisti muskarinskog receptora
JP2009500441A5 (cs)
ATE269865T1 (de) Pyrazolo(3,4-g)chinoxaline als pdgf-rezeptor protein tyrosin-kinase inhibitoren
ES2866401T3 (es) Complejo poco soluble o solvato del mismo, composición farmacéutica y aplicación de los mismos
JP2004524349A5 (cs)
JP2005529935A5 (cs)
KR940702726A (ko) 치환된 퀴놀린-3-카르복시아미드 화합물의 용도 및 이를 이용한 다발성 경화증의 치료방법
IL163608A (en) Sulfonanilides are conserved in their amino / amino acids and derivatives, their process, their pharmaceutical preparations, and their conjugated antibodies and their use in the preparation of drugs for the treatment of culture disorders
JP2015510496A5 (cs)
JP2006518726A5 (cs)

Legal Events

Date Code Title Description
IF Valid on the event date
SP73 Change of data on owner

Owner name: SANOFI-AVENTIS; FR

Effective date: 20050325

KO00 Lapse of patent

Effective date: 20100531