ZA937276B - Quarternary basic amides method of preparing them and pharmaceutical compositions in which they are present - Google Patents

Quarternary basic amides method of preparing them and pharmaceutical compositions in which they are present

Info

Publication number: ZA937276B
Authority: ZA; South Africa
Prior art keywords: group; alkyl; quarternary; preparing; present
Prior art date: 1992-09-30

Application number

ZA937276A

Other languages

English (en)

Inventor

Xavier Emonds-Alt

Patrick Gueule

Vincenzo Proietto

Didier Van Broeck

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-30

Filing date

1993-09-30

Publication date

1994-04-25

1993-09-30 Application filed by Sanofi Elf filed Critical Sanofi Elf

1994-04-25 Publication of ZA937276B publication Critical patent/ZA937276B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Indole Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)

ZA937276A 1992-09-30 1993-09-30 Quarternary basic amides method of preparing them and pharmaceutical compositions in which they are present ZA937276B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9212083A FR2696178B1 (fr)	1992-09-30	1992-09-30	Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number	Publication Date
ZA937276B true ZA937276B (en)	1994-04-25

Family

ID=9434374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA937276A ZA937276B (en)	1992-09-30	1993-09-30	Quarternary basic amides method of preparing them and pharmaceutical compositions in which they are present

Country Status (27)

Country	Link
EP (1)	EP0591040B1 (xx)
JP (2)	JP2857041B2 (xx)
KR (1)	KR100279084B1 (xx)
CN (1)	CN1036652C (xx)
AT (1)	ATE176469T1 (xx)
AU (1)	AU674875B2 (xx)
BR (1)	BR9303982A (xx)
CA (1)	CA2107432C (xx)
CZ (1)	CZ287272B6 (xx)
DE (1)	DE69323375T2 (xx)
DK (1)	DK0591040T3 (xx)
ES (1)	ES2130238T3 (xx)
FI (1)	FI114474B (xx)
FR (1)	FR2696178B1 (xx)
GR (1)	GR3030000T3 (xx)
HU (2)	HU215848B (xx)
IL (1)	IL107158A0 (xx)
MX (1)	MX9306024A (xx)
MY (1)	MY108881A (xx)
NO (1)	NO304888B1 (xx)
NZ (1)	NZ248821A (xx)
OA (1)	OA09869A (xx)
RU (1)	RU2120436C1 (xx)
SG (1)	SG47807A1 (xx)
SI (1)	SI9300513B (xx)
TW (1)	TW242625B (xx)
ZA (1)	ZA937276B (xx)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5583134A (en) *	1992-09-30	1996-12-10	Sanofi	1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
FR2717804B1 (fr) *	1994-03-25	1996-06-21	Sanofi Sa	Sels de composés hétéroaromatiques azotés substitués, procédé pour leur préparation et compositions pharmaceutiques en contenant.
FR2717802B1 (fr) *	1994-03-25	1996-06-21	Sanofi Sa	Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant.
IL113472A0 (en)	1994-04-29	1995-07-31	Lilly Co Eli	Non-peptidyl tachykinin receptor antogonists
AU688072B2 (en)	1994-07-12	1998-03-05	Eli Lilly And Company	Heterocyclic tachykinin receptor antagonists
FR2725900B1 (fr) *	1994-10-21	1997-07-18	Sanofi Sa	Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
US6008223A (en) *	1994-10-27	1999-12-28	Zeneca Limited	Therapeutic compounds
GB9421709D0 (en) *	1994-10-27	1994-12-14	Zeneca Ltd	Therapeutic compounds
EP0714891A1 (en) *	1994-11-22	1996-06-05	Eli Lilly And Company	Heterocyclic tachykinin receptor antagonists
FR2751654B1 (fr) *	1996-07-26	1998-10-23	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729954B1 (fr) *	1995-01-30	1997-08-01	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729952B1 (fr) *	1995-01-30	1997-04-18	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729951B1 (fr) *	1995-01-30	1997-04-18	Sanofi Sa	Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
EP0848706B1 (en) *	1995-06-06	2003-02-05	Schering Corporation	Substituted benzene-fused heterocyclics as neurokinin antagonists
US5654316A (en) *	1995-06-06	1997-08-05	Schering Corporation	Piperidine derivatives as neurokinin antagonists
FR2745811B1 (fr)	1996-03-07	1998-05-22	Sanofi Sa	Glutarimide disubstitue procede pour sa preparation, et son utilisation
AU3149297A (en) *	1996-05-24	1997-12-09	Eli Lilly And Company	Methods of treating hypertension
US5691362A (en) *	1996-06-05	1997-11-25	Schering-Plough Corporation	Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
GB9617730D0 (en) *	1996-08-23	1996-10-02	Pfizer Ltd	Quarternary ammonium compounds
FR2759584B1 (fr) *	1997-02-17	1999-06-11	Sanofi Sa	Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire
FR2759585B1 (fr) *	1997-02-17	1999-06-11	Sanofi Sa	Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique
WO1998047513A1 (en) *	1997-04-24	1998-10-29	Merck Sharp & Dohme Limited	Use of nk-1 receptor antagonists for treating eating disorders
GB9712882D0 (en) *	1997-06-18	1997-08-20	Pfizer Ltd	Quaternary ammonium compounds
GB9716463D0 (en) *	1997-08-04	1997-10-08	Merck Sharp & Dohme	Therapeutic agents
CA2298777A1 (en) *	1997-08-04	1999-02-18	Merck Sharp & Dohme Limited	Use of nk-1 receptor antagonists for treating mania
GB9716457D0 (en) *	1997-08-04	1997-10-08	Merck Sharp & Dohme	Therapeutic agents
CA2298779A1 (en) *	1997-08-04	1999-02-18	Merck Sharp & Dohme Limited	Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
GB9816897D0 (en) *	1998-08-04	1998-09-30	Merck Sharp & Dohme	Therapeutic use
GB9927125D0 (en)	1999-11-16	2000-01-12	Univ Reading The	Placental human neurokinin B precursor
US7560549B2 (en)	2004-02-25	2009-07-14	Sankyo Company, Limited	Sulfonyloxy derivatives
CA2601709C (en)	2005-03-22	2017-02-14	Azevan Pharmaceuticals, Inc.	Beta-lactamylalkanoic acids
RU2466991C2 (ru)	2005-07-19	2012-11-20	Эйзеван Фармасьютиклз, Инк.	β-ЛАКТАМИЛЗАМЕЩЕННЫЕ АНАЛОГИ ФЕНИЛАЛАНИНА, ЦИСТЕИНА И СЕРИНА В КАЧЕСТВЕ АНТАГОНИСТОВ ВАЗОПРЕССИНА
JP2010516731A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
ES2858499T3 (es)	2010-07-01	2021-09-30	Azevan Pharmaceuticals Inc	Compuestos para su uso en el tratamiento de trastorno explosivo intermitente
EP3122743B1 (en)	2014-03-28	2022-11-09	Azevan Pharmaceuticals, Inc.	Compositions and methods for treating neurodegenerative diseases
EP3556435B1 (en) *	2016-12-14	2020-10-28	Beijing Showby Pharmaceutical Co., Ltd.	Class of bifunctional compounds with quaternary ammonium salt structure
AU2018333051B2 (en)	2017-09-15	2024-03-21	Azevan Pharmaceuticals, Inc.	Compositions and methods for treating brain injury

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE903957A1 (en) *	1989-11-06	1991-05-08	Sanofi Sa	Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2666185B1 (fr) *	1990-08-21	1992-12-04	Sgs Thomson Microelectronics	Convertisseur analogique/numerique a interpolation.
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical preparations containing them

1992
- 1992-09-30 FR FR9212083A patent/FR2696178B1/fr not_active Expired - Fee Related
1993
- 1993-09-13 TW TW082107498A patent/TW242625B/zh active
- 1993-09-28 KR KR1019930020216A patent/KR100279084B1/ko not_active IP Right Cessation
- 1993-09-28 EP EP93402362A patent/EP0591040B1/fr not_active Expired - Lifetime
- 1993-09-28 DK DK93402362T patent/DK0591040T3/da active
- 1993-09-28 SG SG1996004468A patent/SG47807A1/en unknown
- 1993-09-28 AT AT93402362T patent/ATE176469T1/de not_active IP Right Cessation
- 1993-09-28 DE DE69323375T patent/DE69323375T2/de not_active Expired - Fee Related
- 1993-09-28 ES ES93402362T patent/ES2130238T3/es not_active Expired - Lifetime
- 1993-09-29 MX MX9306024A patent/MX9306024A/es not_active IP Right Cessation
- 1993-09-29 IL IL107158A patent/IL107158A0/xx not_active IP Right Cessation
- 1993-09-29 MY MYPI93001979A patent/MY108881A/en unknown
- 1993-09-29 NO NO933481A patent/NO304888B1/no not_active IP Right Cessation
- 1993-09-29 CN CN93118177A patent/CN1036652C/zh not_active Expired - Fee Related
- 1993-09-29 OA OA60420A patent/OA09869A/fr unknown
- 1993-09-29 RU RU93055131/04A patent/RU2120436C1/ru not_active IP Right Cessation
- 1993-09-29 CZ CZ19932035A patent/CZ287272B6/cs not_active IP Right Cessation
- 1993-09-29 FI FI934273A patent/FI114474B/fi active IP Right Grant
- 1993-09-30 ZA ZA937276A patent/ZA937276B/xx unknown
- 1993-09-30 HU HUP9302770A patent/HU215848B/hu not_active IP Right Cessation
- 1993-09-30 BR BR9303982A patent/BR9303982A/pt not_active Application Discontinuation
- 1993-09-30 SI SI9300513A patent/SI9300513B/sl not_active IP Right Cessation
- 1993-09-30 NZ NZ248821A patent/NZ248821A/en not_active IP Right Cessation
- 1993-09-30 JP JP5268295A patent/JP2857041B2/ja not_active Expired - Fee Related
- 1993-09-30 CA CA002107432A patent/CA2107432C/en not_active Expired - Fee Related
- 1993-09-30 AU AU48708/93A patent/AU674875B2/en not_active Ceased
1995
- 1995-06-28 HU HU95P/P00518P patent/HU211889A9/hu unknown
1997
- 1997-12-25 JP JP35863297A patent/JP3243212B2/ja not_active Expired - Fee Related
1999
- 1999-04-20 GR GR990401079T patent/GR3030000T3/el unknown

Also Published As

Publication number	Publication date
HU9302770D0 (en)	1993-12-28
SG47807A1 (en)	1998-04-17
NO304888B1 (no)	1999-03-01
DK0591040T3 (da)	1999-09-20
JPH10175976A (ja)	1998-06-30
AU674875B2 (en)	1997-01-16
CZ203593A3 (en)	1994-04-13
DE69323375T2 (de)	1999-06-24
HU215848B (hu)	1999-04-28
CN1088582A (zh)	1994-06-29
FR2696178A1 (fr)	1994-04-01
NO933481D0 (no)	1993-09-29
JP3243212B2 (ja)	2002-01-07
JP2857041B2 (ja)	1999-02-10
TW242625B (xx)	1995-03-11
CA2107432C (en)	2000-04-04
CA2107432A1 (en)	1994-03-31
HU211889A9 (en)	1995-12-28
FR2696178B1 (fr)	1994-12-30
ES2130238T3 (es)	1999-07-01
IL107158A0 (en)	1993-12-28
BR9303982A (pt)	1994-10-25
NZ248821A (en)	1995-10-26
MY108881A (en)	1996-11-30
FI934273A (fi)	1994-03-31
FI114474B (fi)	2004-10-29
KR940007026A (ko)	1994-04-26
SI9300513B (sl)	2002-02-28
CN1036652C (zh)	1997-12-10
GR3030000T3 (en)	1999-07-30
CZ287272B6 (en)	2000-10-11
NO933481L (no)	1994-04-05
EP0591040A1 (fr)	1994-04-06
FI934273A0 (fi)	1993-09-29
OA09869A (fr)	1994-08-15
DE69323375D1 (de)	1999-03-18
EP0591040B1 (fr)	1999-02-03
KR100279084B1 (ko)	2001-01-15
HUT65759A (en)	1994-07-28
JPH06211850A (ja)	1994-08-02
SI9300513A (en)	1994-06-30
MX9306024A (es)	1994-03-31
AU4870893A (en)	1994-04-14
ATE176469T1 (de)	1999-02-15
RU2120436C1 (ru)	1998-10-20

Publication	Publication Date	Title
ZA937276B (en)	1994-04-25	Quarternary basic amides method of preparing them and pharmaceutical compositions in which they are present
RU93055131A (ru)	1996-04-27	Четвертичные амиды основного характера, способ их получения и содержащая их фармацевтическая композиция
SG64368A1 (en)	1999-04-27	Dermorphin analogs their methods of preparation pharmaceutical compositions and methods of therapeutic treatment using the same
WO1990004918A3 (en)	1990-08-09	Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
IL93832A0 (en)	1990-12-23	Pharmaceutical compositions containing 8-substituted xanthines and certain such compounds
FR2613624B1 (fr)	1990-11-23	Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines
GB9310582D0 (en)	1993-07-07	Pharmaceuticals
ZA898678B (en)	1990-09-26	Compositions and compounds
DE3269309D1 (en)	1986-04-03	Pyrrolo(2,3-d)carbazole derivatives, preparation thereof and their therapeutical use
IL67970A0 (en)	1983-06-15	Psoralen derivatives,their preparation and pharmaceutical and cosmetic compositions containing them
IL84895A0 (en)	1988-06-30	Quaternary halide salts of cinnamate esters,their preparation and their use as sunscreen agents
IE872578L (en)	1988-03-26	Antigestagen compositions
ES8503356A1 (es)	1985-02-16	Un procedimiento para la preparacion de nuevos derivados de fosfato.
IL106080A (en)	1997-06-10	Pharmaceutical compositions containing amidinoalkane-1, 1-bisphosphonic acids and some such novel compounds
ES8201151A1 (es)	1981-12-01	Procedimiento para la preparacion de acidos 5-sulfamoilorta-nilicos
ZA922252B (en)	1993-09-27	Bis-Naphthalimides containing amino acid derived linkers as anticancer agents
HU895452D0 (en)	1990-01-28	Process for the preparation of pharmaceutical compositions of new dose form