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MX9306024A - Amidas basicas cuaternarias, procedimiento para supreparacion y composiciones farmaceuticas que las contienen. - Google Patents

Amidas basicas cuaternarias, procedimiento para supreparacion y composiciones farmaceuticas que las contienen.

Info

Publication number
MX9306024A
MX9306024A MX9306024A MX9306024A MX9306024A MX 9306024 A MX9306024 A MX 9306024A MX 9306024 A MX9306024 A MX 9306024A MX 9306024 A MX9306024 A MX 9306024A MX 9306024 A MX9306024 A MX 9306024A
Authority
MX
Mexico
Prior art keywords
group
alkyl
supreparation
procedure
contain
Prior art date
Application number
MX9306024A
Other languages
English (en)
Inventor
Didier Van Broeck
Xavier Emonds-Alt
Patrick Gueule
Vincenzo Proietto
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Publication of MX9306024A publication Critical patent/MX9306024A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

La invención se refiere a las amidas básicas cuaternarias de fórmula: (Ver Fórmula); en las cuales -Ar representa un grupo aromático o heteroaromático mono-, di- o tricíclico, eventualmente substituido; - T representa un enlace directo, un grupo hidroxi-metileno, un grupo alcoximetileno cuyo grupo alcoxi es de 1 a 4 átomos de carbono o un grupo alquileno de 1 a 5 átomos de carbono; - Ar' representa un fenilo no substituido o substituido una o más veces, un grupo tienilo; un grupo benzotienilo; un grupo naftilo o un grupo indolilo; - R representa hidrógeno, un alquilo de 1 a 4 átomos de carbono, un w-alcoxi de 1 a 4 átomos de carbono-alquilo de 2 a 4 átomos de carbono; o un w-alcanoil-oxi de 2 a 4 átomos de carbono-alquilo de 2 a 4 átomos de carbono; - Q representa hidrógeno, - o bien Q y R, conjuntamente, forman un grupo 1,2- etileno, 1,3-propileno o 1,4-butileno; - Am + representa el radical (Ver Fórmula); en el cual X1, X2 X3, conjuntamente y con el átomo de nitrógeno al cual están unidos, forman un sistema azabicíclico o azatricíclico eventualmente substituido por un grupo fenilo; - A - es un anión farmacéuticamente aceptable. Estos compuestos son útiles para la preparación de medicamentos destinados a tratar las patologías que implican el sistema de las taquiquininas.
MX9306024A 1992-09-30 1993-09-29 Amidas basicas cuaternarias, procedimiento para supreparacion y composiciones farmaceuticas que las contienen. MX9306024A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9212083A FR2696178B1 (fr) 1992-09-30 1992-09-30 Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number Publication Date
MX9306024A true MX9306024A (es) 1994-03-31

Family

ID=9434374

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306024A MX9306024A (es) 1992-09-30 1993-09-29 Amidas basicas cuaternarias, procedimiento para supreparacion y composiciones farmaceuticas que las contienen.

Country Status (27)

Country Link
EP (1) EP0591040B1 (es)
JP (2) JP2857041B2 (es)
KR (1) KR100279084B1 (es)
CN (1) CN1036652C (es)
AT (1) ATE176469T1 (es)
AU (1) AU674875B2 (es)
BR (1) BR9303982A (es)
CA (1) CA2107432C (es)
CZ (1) CZ287272B6 (es)
DE (1) DE69323375T2 (es)
DK (1) DK0591040T3 (es)
ES (1) ES2130238T3 (es)
FI (1) FI114474B (es)
FR (1) FR2696178B1 (es)
GR (1) GR3030000T3 (es)
HU (2) HU215848B (es)
IL (1) IL107158A0 (es)
MX (1) MX9306024A (es)
MY (1) MY108881A (es)
NO (1) NO304888B1 (es)
NZ (1) NZ248821A (es)
OA (1) OA09869A (es)
RU (1) RU2120436C1 (es)
SG (1) SG47807A1 (es)
SI (1) SI9300513B (es)
TW (1) TW242625B (es)
ZA (1) ZA937276B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583134A (en) * 1992-09-30 1996-12-10 Sanofi 1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
FR2717804B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Sels de composés hétéroaromatiques azotés substitués, procédé pour leur préparation et compositions pharmaceutiques en contenant.
FR2717802B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant.
IL113472A0 (en) 1994-04-29 1995-07-31 Lilly Co Eli Non-peptidyl tachykinin receptor antogonists
AU688072B2 (en) 1994-07-12 1998-03-05 Eli Lilly And Company Heterocyclic tachykinin receptor antagonists
FR2725900B1 (fr) * 1994-10-21 1997-07-18 Sanofi Sa Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9421709D0 (en) * 1994-10-27 1994-12-14 Zeneca Ltd Therapeutic compounds
EP0714891A1 (en) * 1994-11-22 1996-06-05 Eli Lilly And Company Heterocyclic tachykinin receptor antagonists
FR2751654B1 (fr) * 1996-07-26 1998-10-23 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729952B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729951B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
EP0848706B1 (en) * 1995-06-06 2003-02-05 Schering Corporation Substituted benzene-fused heterocyclics as neurokinin antagonists
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
FR2745811B1 (fr) 1996-03-07 1998-05-22 Sanofi Sa Glutarimide disubstitue procede pour sa preparation, et son utilisation
AU3149297A (en) * 1996-05-24 1997-12-09 Eli Lilly And Company Methods of treating hypertension
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
GB9617730D0 (en) * 1996-08-23 1996-10-02 Pfizer Ltd Quarternary ammonium compounds
FR2759584B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire
FR2759585B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique
WO1998047513A1 (en) * 1997-04-24 1998-10-29 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating eating disorders
GB9712882D0 (en) * 1997-06-18 1997-08-20 Pfizer Ltd Quaternary ammonium compounds
GB9716463D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
CA2298777A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating mania
GB9716457D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
CA2298779A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
GB9927125D0 (en) 1999-11-16 2000-01-12 Univ Reading The Placental human neurokinin B precursor
US7560549B2 (en) 2004-02-25 2009-07-14 Sankyo Company, Limited Sulfonyloxy derivatives
CA2601709C (en) 2005-03-22 2017-02-14 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids
RU2466991C2 (ru) 2005-07-19 2012-11-20 Эйзеван Фармасьютиклз, Инк. β-ЛАКТАМИЛЗАМЕЩЕННЫЕ АНАЛОГИ ФЕНИЛАЛАНИНА, ЦИСТЕИНА И СЕРИНА В КАЧЕСТВЕ АНТАГОНИСТОВ ВАЗОПРЕССИНА
JP2010516731A (ja) 2007-01-24 2010-05-20 グラクソ グループ リミテッド ２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
ES2858499T3 (es) 2010-07-01 2021-09-30 Azevan Pharmaceuticals Inc Compuestos para su uso en el tratamiento de trastorno explosivo intermitente
EP3122743B1 (en) 2014-03-28 2022-11-09 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
EP3556435B1 (en) * 2016-12-14 2020-10-28 Beijing Showby Pharmaceutical Co., Ltd. Class of bifunctional compounds with quaternary ammonium salt structure
AU2018333051B2 (en) 2017-09-15 2024-03-21 Azevan Pharmaceuticals, Inc. Compositions and methods for treating brain injury

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2666185B1 (fr) * 1990-08-21 1992-12-04 Sgs Thomson Microelectronics Convertisseur analogique/numerique a interpolation.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
HU9302770D0 (en) 1993-12-28
SG47807A1 (en) 1998-04-17
NO304888B1 (no) 1999-03-01
DK0591040T3 (da) 1999-09-20
JPH10175976A (ja) 1998-06-30
AU674875B2 (en) 1997-01-16
CZ203593A3 (en) 1994-04-13
DE69323375T2 (de) 1999-06-24
HU215848B (hu) 1999-04-28
CN1088582A (zh) 1994-06-29
FR2696178A1 (fr) 1994-04-01
NO933481D0 (no) 1993-09-29
JP3243212B2 (ja) 2002-01-07
JP2857041B2 (ja) 1999-02-10
TW242625B (es) 1995-03-11
CA2107432C (en) 2000-04-04
CA2107432A1 (en) 1994-03-31
HU211889A9 (en) 1995-12-28
FR2696178B1 (fr) 1994-12-30
ES2130238T3 (es) 1999-07-01
IL107158A0 (en) 1993-12-28
ZA937276B (en) 1994-04-25
BR9303982A (pt) 1994-10-25
NZ248821A (en) 1995-10-26
MY108881A (en) 1996-11-30
FI934273A (fi) 1994-03-31
FI114474B (fi) 2004-10-29
KR940007026A (ko) 1994-04-26
SI9300513B (sl) 2002-02-28
CN1036652C (zh) 1997-12-10
GR3030000T3 (en) 1999-07-30
CZ287272B6 (en) 2000-10-11
NO933481L (no) 1994-04-05
EP0591040A1 (fr) 1994-04-06
FI934273A0 (fi) 1993-09-29
OA09869A (fr) 1994-08-15
DE69323375D1 (de) 1999-03-18
EP0591040B1 (fr) 1999-02-03
KR100279084B1 (ko) 2001-01-15
HUT65759A (en) 1994-07-28
JPH06211850A (ja) 1994-08-02
SI9300513A (en) 1994-06-30
AU4870893A (en) 1994-04-14
ATE176469T1 (de) 1999-02-15
RU2120436C1 (ru) 1998-10-20

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Legal Events

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FG Grant or registration
HC Change of company name or juridical status

Owner name: TENCEL LIMITED.*

MM Annulment or lapse due to non-payment of fees