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SG11201907580SA - Combination therapies for treatment of bcma-related cancers and autoimmune disorders - Google Patents

Combination therapies for treatment of bcma-related cancers and autoimmune disorders

Info

Publication number
SG11201907580SA
SG11201907580SA SG11201907580SA SG11201907580SA SG11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA
Authority
SG
Singapore
Prior art keywords
international
bcma
seattle
rule
combination
Prior art date
Application number
SG11201907580SA
Inventor
Stanley Riddell
Damian Green
Tyler Hill
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of SG11201907580SA publication Critical patent/SG11201907580SA/en

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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date IiiimmoimiolollmonolomolEmolmoolliflovoimIE (10) International Publication Number WO 2018/151836 Al 23 August 2018 (23.08.2018) WIPOIPCT (51) International Patent Classification: (72) Inventors: RIDDELL, Stanley, R.; 1763 268th Place SE, A61K 31/55 (2006.01) A61P 35/02 (2006.01) Sammamish, WA 98075 (US). GREEN, Damian; 2746 NE A61K 39/395 (2006.01) A61P 37/00 (2006.01) 88th Street, Seattle, WA 98115 (US). HILL, Tuler; 1315 A61K 35/17 (2015.01) A61K 45/06 (2006.01) N 88th Street, Seattle, WA 98103 (US). A61P 37/02 (2006.01) Cl 2N 15/62 (2006.01) A61P 35/00 (2006.01) (74) Agent: PEPE, Jeffrey, C. et al.; Seed Intellectual Property, Law Group LLP, 701 Fifth Avenue, Suite 5400, Seattle, WA (21) International Application Number: PCT/US2018/000050 (22) International Filing Date: 16 February 2018 (16.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/460,612 17 February 2017 (17.02.2017) US 62/582,270 06 November 2017 (06.11.2017) US (71) Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER [US/US]; 1100 Fairview Avenue North, Seattle, WA 98109 (US). 98104-7064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (54) Title: COMBINATION THERAPIES FOR TREATMENT OF BCMA-RELATED CANCERS AND AUTOIMMUNE DISORDERS C113ST 0mg/kg C113ST 3C mg/kg FMC63 30mg/kg •• , ;A.,. 49043001ft 4 , 0PC4 A 1 4 . A Oe ? 49$1 VP 4VQ30:0101 )40: C g C :4' 114. I I GC kr) 00 O 1-1 1-1 N C 0 ( .2 H FIG. 7B (57) : The present disclosure relates to methods for using BCMA-specific binding molecules (such as a BCMA-specific chimeric antigen receptor or antibody) in combination with y-secretase inhibitors, which can be done concurrently or sequentially, to treat or prevent a B-cell related proliferative disease, such as a cancer or autoimmune disease, or the like. A BCMA-specific binding molecule in combination with y-secretase inhibitor can be used in, for example, adoptive immunotherapy. [Continued on next page] WO 2018/151836 Al MIDEDIMOMOIDEIREE3110111MOROMEEN GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
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Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
NZ630178A (en) 2012-09-07 2017-06-30 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r antagonist
TWI697334B (en) 2013-06-04 2020-07-01 美商再生元醫藥公司 Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor
TWI682781B (en) 2013-07-11 2020-01-21 美商再生元醫藥公司 Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
ES2973858T3 (en) 2014-02-28 2024-06-24 Regeneron Pharma Methods for treating skin infections by administering an IL-4R antagonist
MX2017001011A (en) 2014-07-21 2018-05-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor.
CA3035202A1 (en) 2016-09-01 2018-03-08 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an il-4r antagonist
WO2018057776A1 (en) 2016-09-22 2018-03-29 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an il-4r inhibitor
IL268349B2 (en) 2017-02-17 2024-08-01 Hutchinson Fred Cancer Res Combination therapies for the treatment of BCMA-associated cancer and autoimmune disorders
EP3615068A1 (en) * 2017-04-28 2020-03-04 Novartis AG Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
EP3615055A1 (en) * 2017-04-28 2020-03-04 Novartis AG Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
KR102794702B1 (en) 2017-09-01 2025-04-11 다나-파버 캔서 인스티튜트 인크. Immunogenic peptides specific for BCMA and TACI antigens for the treatment of cancer
JP7233425B2 (en) 2017-11-06 2023-03-06 ジュノー セラピューティクス インコーポレイテッド Combination of cell therapy and gamma secretase inhibitor
AU2019266150A1 (en) * 2018-05-06 2021-01-07 Ayala Pharmaceuticals Inc. Combination compositions comprising bisfluoroalkyl-1,4- benzodiazepinone compounds and methods of use thereof
EP3790553A4 (en) * 2018-05-06 2022-04-20 Ayala Pharmaceuticals Inc. Compositions comprising cd20 inhibitors and bisfluoroalkyl-1,4-benzodiazepinone compounds and methods of use thereof
AU2019270940A1 (en) 2018-05-13 2020-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an IL-4R inhibitor
EP3801551A4 (en) * 2018-05-24 2022-04-06 Ayala Pharmaceuticals Inc. COMPOSITIONS COMPRISING BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS AND IMMUNOTHERAPEUTIC AGENTS AND METHODS OF USE THEREOF
BR112020024351A2 (en) 2018-06-01 2021-02-23 Novartis Ag binding molecules against bcma and uses thereof
CA3100724A1 (en) 2018-06-13 2019-12-19 Novartis Ag B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof
CN119954969A (en) 2018-07-19 2025-05-09 瑞泽恩制药公司 Chimeric antigen receptors specific for BCMA and uses thereof
TWI838389B (en) 2018-07-19 2024-04-11 美商再生元醫藥公司 BISPECIFIC ANTI-BCMAxANTI-CD3 ANTIBODIES AND USES THEREOF
CN109503716B (en) * 2018-10-08 2021-04-27 浙江生研生物科技有限公司 A bispecific chimeric antigen receptor molecule and its application in tumor therapy
EP3874272A1 (en) * 2018-10-31 2021-09-08 GlaxoSmithKline Intellectual Property Development Limited Methods of treating cancer
EP3941938A1 (en) * 2019-03-06 2022-01-26 Dana-Farber Cancer Institute, Inc. T cell receptors specific to b-cell maturation antigen for treatment of cancer
CN121102493A (en) 2019-03-21 2025-12-12 瑞泽恩制药公司 A combination of IL-4/IL-13 pathway inhibitors and plasma cell ablation used to treat allergies.
MX2021013351A (en) * 2019-04-30 2022-01-31 Memorial Sloan Kettering Cancer Center COMBINATION THERAPIES.
CN113874398B (en) 2019-05-21 2025-08-01 诺华股份有限公司 CD19 binding molecules and uses thereof
US12023354B2 (en) * 2019-05-31 2024-07-02 Case Western Reserve University Targeting B cell activating factor receptor (BAFF-R) using ligand-based chimeric antigen receptor (CAR)-T cells
JP2022543815A (en) 2019-08-05 2022-10-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
EP4010373A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
WO2021051390A1 (en) * 2019-09-20 2021-03-25 上海吉倍生物技术有限公司 Bcma-targeted antibody and chimeric antigen receptor
US20230112444A1 (en) * 2020-01-16 2023-04-13 Springworks Therapeutics, Inc. Combination therapies of chimeric antigen receptors targeting b-cell maturation antigen and gamma secretase inhibitors
CN111234020B (en) * 2020-01-23 2020-10-23 和铂医药(苏州)有限公司 BCMA binding protein and preparation method and application thereof
TW202200132A (en) * 2020-03-13 2022-01-01 美商斯普林渥克斯治療有限公司 A combination therapy with nirogacestat and a bcma-directed therapy and uses thereof
WO2021209498A1 (en) * 2020-04-14 2021-10-21 Julius-Maximilians-Universität Würzburg Combination therapy of atra or other retinoids with immunotherapeutic agents binding to bcma
WO2022035793A1 (en) 2020-08-10 2022-02-17 Precision Biosciences, Inc. Antibodies and fragments specific for b-cell maturation antigen and uses thereof
AU2021329507A1 (en) * 2020-08-20 2023-03-09 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating respiratory diseases characterized by mucus hypersecretion
MX2024002590A (en) 2021-09-01 2024-03-22 Springworks Therapeutics Inc Synthesis of nirogacestat.
WO2023044633A1 (en) * 2021-09-22 2023-03-30 南京驯鹿医疗技术有限公司 Application of bcma car-t in preparation of drug for treating autoimmune diseases
WO2023064872A1 (en) 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
WO2024228989A1 (en) * 2023-05-01 2024-11-07 Caribou Biosciences, Inc. Treatment of autoimmune diseases with bcma-targeting engineered immune cells
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells
US20250242056A1 (en) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing
US20250242018A1 (en) 2024-01-26 2025-07-31 Regeneron Pharmaceuticals, Inc. Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration
WO2025184567A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response

Family Cites Families (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1999A (en) 1841-03-12 Improvement in seed-planters
CA136551A (en) 1911-08-03 1911-10-31 Hedwig Heeron Rolling mill
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
WO1990007380A2 (en) 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
WO1992008796A1 (en) 1990-11-13 1992-05-29 Immunex Corporation Bifunctional selectable fusion genes
EP0804590A1 (en) 1993-05-21 1997-11-05 Targeted Genetics Corporation Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
EP0737207B1 (en) 1994-01-11 2004-09-22 Dyax Corporation Inhibitors of human plasmin derived from the kunitz domains
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
WO1996018105A1 (en) 1994-12-06 1996-06-13 The President And Fellows Of Harvard College Single chain t-cell receptor
US20020150914A1 (en) 1995-06-30 2002-10-17 Kobenhavns Universitet Recombinant antibodies from a phage display library, directed against a peptide-MHC complex
DE19608753C1 (en) 1996-03-06 1997-06-26 Medigene Gmbh Transduction system based on rep-negative adeno-associated virus vector
US6451995B1 (en) 1996-03-20 2002-09-17 Sloan-Kettering Institute For Cancer Research Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods
AU749658C (en) 1996-12-23 2004-04-29 Elan Pharmaceuticals, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
JP2001519143A (en) 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション Soluble single-chain T cell receptor protein
US6759243B2 (en) 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
NZ507887A (en) 1998-05-19 2002-12-20 Avidex Ltd Soluble T cell receptor
EP1109921A4 (en) 1998-09-04 2002-08-28 Sloan Kettering Inst Cancer FOR PROSTATE-SPECIFIC MEMBRANE-ANTI-SPECIFIC FUSION RECEPTORS AND THEIR USE
JP2002526109A (en) 1998-10-02 2002-08-20 ザ ガバメント オブ ザ ユナイテッドステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ ザ ナショナル インステ Apoptosis inducers and methods
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
AU779875B2 (en) 2000-01-24 2005-02-17 Merck Sharp & Dohme Limited Gamma-secretase inhibitors
GB0005251D0 (en) 2000-03-03 2000-04-26 Merck Sharp & Dohme Therapeutic compounds
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
GB0008710D0 (en) 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic compounds
EP1287357A2 (en) 2000-06-02 2003-03-05 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
KR20120053525A (en) 2000-06-16 2012-05-25 캠브리지 안티바디 테크놀로지 리미티드 Antibodies that immunospecifically bind to blys
EP1334085B1 (en) 2000-11-02 2005-08-24 Merck Sharp & Dohme Ltd. Sulfamides as gamma-secretase inhibitors
EP1334188B1 (en) 2000-11-07 2006-08-30 City of Hope Cd19-specific redirected immune cells
US20030012783A1 (en) 2001-02-20 2003-01-16 Wayne Kindsvogel Antibodies that bind both BCMA and TACI
DE10113776B4 (en) 2001-03-21 2012-08-09 "Iba Gmbh" Isolated streptavidin-binding, competitively elutable peptide, this comprehensive fusion peptide, nucleic acid coding therefor, expression vector, methods for producing a recombinant fusion protein and methods for detecting and / or obtaining the fusion protein
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
NZ531208A (en) 2001-08-31 2005-08-26 Avidex Ltd Multivalent soluble T cell receptor (TCR) complexes
US7939059B2 (en) 2001-12-10 2011-05-10 California Institute Of Technology Method for the generation of antigen-specific lymphocytes
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
CA2476625A1 (en) 2002-02-20 2003-08-28 Dyax Corp. Mhc-peptide complex binding ligands
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
GB0223038D0 (en) 2002-10-04 2002-11-13 Merck Sharp & Dohme Therapeutic compounds
GB0223039D0 (en) 2002-10-04 2002-11-13 Merck Sharp & Dohme Therapeutic compounds
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
GB0225474D0 (en) 2002-11-01 2002-12-11 Merck Sharp & Dohme Therapeutic agents
US7575925B2 (en) 2002-12-10 2009-08-18 Sunnybrook Health Sciences Centre Cell preparations comprising cells of the T cell lineage and methods of making and using them
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
GB0326039D0 (en) 2003-11-07 2003-12-10 Merck Sharp & Dohme Therapeutic agents
WO2006001956A2 (en) 2004-05-20 2006-01-05 The Board Of Trustees Of The University Of Illinois Compositions for inhibiting cell growth and inducing apoptosis in cancer cells and methods of use thereof
WO2005116072A2 (en) 2004-05-27 2005-12-08 Weidanz Jon A Antibodies as t cell receptor mimics, methods of production and uses thereof
US20090226474A1 (en) 2004-05-27 2009-09-10 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
US20090304679A1 (en) 2004-05-27 2009-12-10 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
ATE475669T1 (en) 2004-06-29 2010-08-15 Immunocore Ltd CELLS EXPRESSING A MODIFIED T-CELL RECEPTOR
ES2320374T3 (en) 2005-01-05 2009-05-21 F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. DOMAINS OF SYNTHETIC IMMUNOGLOBULIN WITH MODIFIED LINK PROPERTIES IN MOLECULA REGIONS DIFFERENT FROM COMPLEMENTARITY DETERMINATION REGIONS.
GB0504767D0 (en) 2005-03-08 2005-04-13 Ares Trading Sa Lipocalin protein
US20090215775A1 (en) 2005-05-17 2009-08-27 Huw David Lewis Sulphonamido-Substituted Cyclohexyl Sulphones for Treatment of Cancer
CN105330741B (en) 2005-07-01 2023-01-31 E.R.施贵宝&圣斯有限责任公司 Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
WO2007062090A2 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
EP2198863A1 (en) 2006-02-27 2010-06-23 The Johns Hopkins University Cancer treatment with gamma-secretase inhibitors
EP1829895A1 (en) 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
CN101460518B (en) 2006-06-06 2012-08-22 克鲁塞尔荷兰公司 Human binding molecule with killing activity against enterococcus and staphylococcus aureus and application thereof
WO2008042814A2 (en) 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
WO2008112249A1 (en) 2007-03-13 2008-09-18 Trustees Of Columbia University In The City Of New York Synergistic interaction of notch-1 inhibitors with glucocorticoids
SI2132230T1 (en) 2007-03-22 2014-07-31 Genentech, Inc. Apoptotic anti-ige antibodies binding the membrane-bound ige
PT2856876T (en) 2007-03-30 2018-03-28 Memorial Sloan Kettering Cancer Center CONSTITUTIVE EXPRESSION OF CO-STIMULATING LIGANTS IN TREATY LYMPHOCYTES
MX2010001754A (en) 2007-08-14 2010-05-14 Lilly Co Eli Azepine derivatives as gamma-secretase inhibitors.
RU2010113977A (en) 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) APPLICATION OF THE FIBRINOGEN RECEPTOR ANTAGONIST AND / OR FOLICULAR GONADOLIBERIN PEPTIDE AS A THERAPEUTIC AGAINST TREATMENT OF STREPTOCOCCUS PNEUMONIAE INFECTION
US8377886B2 (en) 2007-09-14 2013-02-19 Albert Einstein College Of Medicine Of Yeshiva University Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease
CA2700391A1 (en) 2007-09-24 2009-04-02 University Of Zuerich Designed armadillo repeat proteins
ATE528077T1 (en) 2007-12-07 2011-10-15 Miltenyi Biotec Gmbh CENTRIFUGE FOR SEPARATING A SAMPLE INTO AT LEAST TWO COMPONENTS
US20120164718A1 (en) 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
EP2307019A1 (en) 2008-06-03 2011-04-13 Fresenius Medical Care Deutschland GmbH Pharmaceutical compositions comprising gamma secretase modulators
EP4032552B1 (en) 2008-08-26 2023-10-04 City of Hope Method and compositions for enhanced anti-tumor effector functioning of t cells
US9221902B2 (en) 2008-11-07 2015-12-29 Fabrus, Inc. Combinatorial antibody libraries and uses thereof
PA8852901A1 (en) 2008-12-22 2010-07-27 Lilly Co Eli PROTEIN CINASE INHIBITORS
CN102421801B (en) 2009-03-10 2016-03-16 比奥根Ma公司 anti-BCMA antibody
US9101559B2 (en) 2009-05-08 2015-08-11 New York University Leukemic cell CNS infiltration controlled by notch-induced chemotaxis
US8569245B2 (en) 2009-06-26 2013-10-29 University Of Florida Research Foundation, Inc. Protease inhibitors, compositions and methods of use
CA2777053A1 (en) 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
HRP20190556T1 (en) 2009-11-03 2019-06-14 City Of Hope TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRANSDUCED T CELL SELECTION
US8637493B2 (en) 2009-11-12 2014-01-28 University Of Massachusetts Methods for treating glioblastoma
CN102085372A (en) 2009-12-04 2011-06-08 中国医学科学院基础医学研究所 Application of Notch pathway inhibitor in treatment of tumors caused by activation of mTOR
WO2011085103A2 (en) 2010-01-06 2011-07-14 Dyax Corp. Plasma kallikrein binding proteins
JP2011178691A (en) 2010-02-26 2011-09-15 Takuya Ueda Catenin-binding probe and use thereof
WO2011108008A2 (en) 2010-03-04 2011-09-09 Transgene Biotek Ltd. Antibody for targeted induction of apoptosis, cdc and adcc mediated killing of cancer cells, tbl-cln1
EP2640750A1 (en) 2010-11-16 2013-09-25 Boehringer Ingelheim International GmbH Agents and methods for treating diseases that correlate with bcma expression
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
JO3003B1 (en) 2011-01-14 2016-09-05 Lilly Co Eli Imidazo [4,5 -c] quinoline-2-one and its use as a PI3 / mtor kinase inhibitor
CN110200997A (en) 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 Method and composition for cellular immunotherapy
US20130101599A1 (en) 2011-04-21 2013-04-25 Boehringer Ingelheim International Gmbh Bcma-based stratification and therapy for multiple myeloma patients
SI3415531T1 (en) 2011-05-27 2023-12-29 Glaxo Group Limited BCMA (CD269/TNFRSF17) - BINDING PROTEINS
AR087107A1 (en) 2011-07-27 2014-02-12 Lilly Co Eli INHIBITOR COMPOUND OF THE SIGNALING OF THE NOTCH TRAJECTORY
WO2013026837A1 (en) 2011-08-23 2013-02-28 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
EP2766015A1 (en) 2011-10-14 2014-08-20 Novartis AG 2-carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases
CN104080797A (en) 2011-11-11 2014-10-01 弗雷德哈钦森癌症研究中心 T cell immunotherapy targeting cyclin A1 against cancer
TWI679212B (en) 2011-11-15 2019-12-11 美商安進股份有限公司 Binding molecules for e3 of bcma and cd3
EP2814846B1 (en) 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
AU2013246443B2 (en) * 2012-04-11 2017-04-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting B-cell maturation antigen
EP2844743B1 (en) 2012-05-03 2021-01-13 Fred Hutchinson Cancer Research Center Enhanced affinity t cell receptors and methods for making the same
EP2674439B1 (en) 2012-06-13 2017-02-01 Rottapharm Biotech S.r.l. Anti-TrkA antibodies, derivatives and uses thereof
SI2884999T2 (en) 2012-08-20 2026-01-30 Fred Hutchinson Cancer Center Method and compositions for cellular immunotherapy
SG11201502598SA (en) 2012-10-02 2015-05-28 Sloan Kettering Inst Cancer Compositions and methods for immunotherapy
JP6694712B2 (en) * 2012-11-01 2020-05-20 マックス−デルブルック−セントラム フアー モレキュラーレ メデジン Antibody against CD269 (BCMA)
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
US9243058B2 (en) 2012-12-07 2016-01-26 Amgen, Inc. BCMA antigen binding proteins
TW201425336A (en) 2012-12-07 2014-07-01 Amgen Inc BCMA antigen binding proteins
ES2667420T3 (en) 2013-02-05 2018-05-10 Engmab Sàrl Bispecific antibodies against cd3epsilon and bcma
EP2954330A4 (en) 2013-02-08 2016-08-31 Inst Myeloma & Bone Cancer Res IMPROVED DIAGNOSTIC, PROGNOSTIC AND MONITORING METHODS FOR MULTIPLE MYELOMA, CHRONIC LYMPHOCYTIC LEUKEMIA AND NON-HODGKIN LYMPHOMA B-CELL LYMPHOMA
SI2961831T1 (en) 2013-02-26 2020-10-30 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
UY35468A (en) 2013-03-16 2014-10-31 Novartis Ag CANCER TREATMENT USING AN ANTI-CD19 CHEMERIC ANTIGEN RECEIVER
ES2645393T3 (en) 2013-05-29 2017-12-05 Cellectis T lymphocyte manipulation methods for immunotherapy using the RNA-guided Cas nuclease system
GB201317929D0 (en) 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
JP6942467B2 (en) 2013-12-20 2021-10-06 フレッド ハッチンソン キャンサー リサーチ センター Tagging chimeric effector molecule and its receptor
WO2015142675A2 (en) 2014-03-15 2015-09-24 Novartis Ag Treatment of cancer using chimeric antigen receptor
US10316101B2 (en) 2014-04-14 2019-06-11 Cellectis BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy
KR102632731B1 (en) 2014-04-30 2024-02-01 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 Humanized antibodies against cd269(bcma)
EP4008725A1 (en) 2014-05-02 2022-06-08 The Trustees of the University of Pennsylvania Compositions and methods of chimeric autoantibody receptor t cells
US10092645B2 (en) 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
MX2017001011A (en) * 2014-07-21 2018-05-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor.
ES2878449T3 (en) * 2014-07-24 2021-11-18 2Seventy Bio Inc BCMA chimeric antigen receptors
EP3023437A1 (en) 2014-11-20 2016-05-25 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
CA2969870A1 (en) 2014-12-05 2016-06-09 Memorial Sloan-Kettering Cancer Center Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof
AU2015357533B2 (en) 2014-12-05 2021-10-07 Eureka Therapeutics, Inc. Antibodies targeting B-cell maturation antigen and methods of use
RS62527B1 (en) 2014-12-12 2021-11-30 2Seventy Bio Inc Bcma chimeric antigen receptors
WO2016164580A1 (en) 2015-04-07 2016-10-13 Novartis Ag Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
TWI609687B (en) 2015-04-14 2018-01-01 美國禮來大藥廠 Targeted treatment of leiomyosarcoma
KR20180033232A (en) * 2015-07-24 2018-04-02 온코트랙커 인코포레이티드 Gamma secretase modulator for the treatment of immune system dysfunction
CN105384825B (en) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 A kind of bispecific chimeric antigen receptor and its application based on single domain antibody
US20180346571A1 (en) 2015-11-17 2018-12-06 Oncomed Pharmaceuticals, Inc. Pd-l1-binding agents and uses thereof
AU2017213844A1 (en) 2016-02-02 2018-08-02 Fred Hutchinson Cancer Center Anti-ROR1 antibodies and uses thereof
WO2017173256A1 (en) 2016-04-01 2017-10-05 Kite Pharma, Inc. Chimeric antigen and t cell receptors and methods of use
RU2747788C2 (en) 2016-04-12 2021-05-14 Эли Лилли Энд Компани Combination therapy with notch and cdk4/6 inhibitors for cancer treatment
CN109310685B (en) 2016-04-12 2021-10-29 伊莱利利公司 Combination therapy of NOTCH and PI3K/MTOR inhibitors for the treatment of cancer
IL263110B (en) 2016-05-20 2022-07-01 Lilly Co Eli Combination therapy with notch and pd-1 or pd-l1 inhibitors
CN116473978A (en) 2016-08-31 2023-07-25 伊莱利利公司 Dosing regimen for treating solid tumors
CA3039405A1 (en) 2016-10-12 2018-04-19 Eli Lilly And Company Targeted treatment of mature t-cell lymphoma
CN110022906A (en) 2016-11-04 2019-07-16 蓝鸟生物公司 Anti-BCMA CAR T Cell Composition
IL268349B2 (en) 2017-02-17 2024-08-01 Hutchinson Fred Cancer Res Combination therapies for the treatment of BCMA-associated cancer and autoimmune disorders
JP7137896B2 (en) 2017-03-24 2022-09-15 レンティジェン・テクノロジー・インコーポレイテッド Compositions and methods for treating cancer with anti-CD33 immunotherapy
WO2018197675A1 (en) 2017-04-28 2018-11-01 Julius-Maximilians-Universität Würzburg Ror1-specific chimeric antigen receptors (car) with humanized targeting domains
EP3615055A1 (en) 2017-04-28 2020-03-04 Novartis AG Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
EP3618842B1 (en) 2017-05-01 2023-10-18 Juno Therapeutics, Inc. Combination of a cell therapy and an immunomodulatory compound
CN107827989A (en) 2017-10-18 2018-03-23 银丰生物工程集团有限公司 Transgenic T cells targeting myeloma BCMA antigen, preparation method and application thereof
JP7447006B2 (en) 2017-11-01 2024-03-11 ジュノー セラピューティクス インコーポレイテッド Chimeric antigen receptor specific for B cell maturation antigen (BCMA)
CA3080904A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for b-cell maturation antigen
JP7233425B2 (en) * 2017-11-06 2023-03-06 ジュノー セラピューティクス インコーポレイテッド Combination of cell therapy and gamma secretase inhibitor
WO2020092848A2 (en) 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen

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