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SG11201908796XA - Improved antigen binding receptors - Google Patents

Improved antigen binding receptors

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Publication number
SG11201908796XA
SG11201908796XA SG11201908796XA SG11201908796XA SG 11201908796X A SG11201908796X A SG 11201908796XA SG 11201908796X A SG11201908796X A SG 11201908796XA SG 11201908796X A SG11201908796X A SG 11201908796XA
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SG
Singapore
Prior art keywords
international
roche
rule
antigen binding
schlieren
Prior art date
Application number
Inventor
Kay-Gunnar Stubenrauch
Ekkehard Moessner
Christian Klein
Diana Darowski
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201908796XA publication Critical patent/SG11201908796XA/en

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4221—CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4264—Cancer antigens from embryonic or fetal origin
    • A61K40/4266—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/50—Colon
    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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Abstract

ATMCD TM CSD CD28 VH CH VL CL linker (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT omit Ill °nolo ow (10) International Publication Number WO 2018/177966 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 14/735 (2006.01) A61K 35/17 (2015.01) C07K 16/28 (2006.01) C07K 14/725 (2006.01) C07K 16/30 (2006.01) C07K 14/705 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/EP2018/057566 (22) International Filing Date: 26 March 2018 (26.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17163090.8 27 March 2017 (27.03.2017) EP (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- sey 07424 (US). (72) Inventors: STUBENRAUCH, Kay-Gunnar; c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). MOESSNER, Ekkehard; c/o Roche Glycart AG, Wagis- trasse 18, 8952 Schlieren (CH). KLEIN, Christian; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). DAROWSKI, Diana; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). (74) Agent: BRODBECK, Michel; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: IMPROVED ANTIGEN BINDING RECEPTORS Figure 1A Figure 1B anti P329G linker VL linker ATM CD28 TM CSD CD28 SSD CD3z anti P329G ATM = anchoring transmembrane domain CSD = co-stimulatory signaling domain SSD CD3z SSD = stimulatory signaling domain scFv Format Fab Format N N (57) : The present disclosure generally relates to antigen binding receptors capable of specific binding to mutated Fc domains 1-1 with reduced Fc receptor binding and T cells expressing these antigen binding receptors. More precisely the application deals with an c)1: 1-1 engineered Fc receptor consisting of a CD3 intracellular domain coupled to CD28 internal and transmembrane domains. The extracel- lular part preferably consists of an anti Pro329Gly antibody variable domain. Uses in cancer therapy and diagnosis C [Continued on next page] WO 2018/177966 Al IMEDIMOMMIONE1013010BEHOIMOVOIMIE SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(0) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
SG11201908796X 2017-03-27 2018-03-26 Improved antigen binding receptors SG11201908796XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17163090 2017-03-27
PCT/EP2018/057566 WO2018177966A1 (en) 2017-03-27 2018-03-26 Improved antigen binding receptors

Publications (1)

Publication Number Publication Date
SG11201908796XA true SG11201908796XA (en) 2019-10-30

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US (2) US11679127B2 (en)
EP (1) EP3600407B1 (en)
JP (2) JP2020515256A (en)
KR (1) KR102712254B1 (en)
CN (1) CN110662560B (en)
AU (1) AU2018241624B2 (en)
BR (1) BR112019020168A2 (en)
CA (1) CA3056837A1 (en)
CL (1) CL2019002717A1 (en)
CR (1) CR20190440A (en)
ES (1) ES3010117T3 (en)
IL (1) IL269531B2 (en)
MA (2) MA49990A (en)
MX (1) MX2019011526A (en)
MY (1) MY205503A (en)
PE (1) PE20200152A1 (en)
SG (1) SG11201908796XA (en)
TW (1) TW201900673A (en)
UA (1) UA128717C2 (en)
WO (1) WO2018177966A1 (en)
ZA (1) ZA201906358B (en)

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MA53982A (en) 2018-10-23 2022-01-26 Dragonfly Therapeutics Inc HETERODIMER PROTEINS FUSED TO FC FRAGMENT
AR117728A1 (en) * 2018-12-21 2021-08-25 Hoffmann La Roche CD28 ANTIGEN BINDING SUPERAGONIST MOLECULES WITH TUMOR TARGET
MA54513A (en) * 2018-12-21 2022-03-30 Hoffmann La Roche CD28 ANTIGEN BINDING MOLECULES TUMOR TARGETING AGONISTS
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CN116507640A (en) * 2020-10-28 2023-07-28 豪夫迈·罗氏有限公司 Improved Antigen Binding Receptor
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CN116284385A (en) * 2021-12-07 2023-06-23 信达细胞制药(苏州)有限公司 P329G antibody targeting BCMA and combination and application of P329G antibody and chimeric antigen receptor cell
CN119095881A (en) * 2022-03-25 2024-12-06 豪夫迈·罗氏有限公司 Improved chimeric receptors
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