[go: up one dir, main page]

SG11201909154SA - Bispecific antibodies specifically binding to pd1 and lag3 - Google Patents

Bispecific antibodies specifically binding to pd1 and lag3

Info

Publication number
SG11201909154SA
SG11201909154SA SG11201909154SA SG11201909154SA SG 11201909154S A SG11201909154S A SG 11201909154SA SG 11201909154S A SG11201909154S A SG 11201909154SA SG 11201909154S A SG11201909154S A SG 11201909154SA
Authority
SG
Singapore
Prior art keywords
roche
international
lag3
wagistrasse
nonnenwald
Prior art date
Application number
Inventor
Deak Laura Codarri
Jens Fischer
Sabine Imhof-Jung
Christian Klein
Stefan Seeber
Patrick Alexander Aaron Weber
Mario Perro
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201909154SA publication Critical patent/SG11201909154SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT omit VIII °nolo OH H ioo im mil ono oimIE (10) International Publication Number WO 2018/185043 Al (51) International Patent Classification: CO7K 16/28 (2006.01) (21) International Application Number: PCT/EP2018/058382 (22) International Filing Date: 03 April 2018 (03.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17165125.0 05 April 2017 (05.04.2017) EP (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- sey 07424 (US). (72) Inventors: CODARRI DEAK, Laura; c/o Roche Gly- cart AG, Wagistrasse 10, 8952 Schlieren (CH). FISCH- ER, Jens; c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). IMHOF-JUNG, Sabine; c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). KLEIN, Christian; c/o Roche Glycart AG, Wagistrasse 10, 8952 Schlieren (CH). SEEBER, Stefan; c/o Roche Diag- nostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). WE- BER, Patrick Alexander Aaron; c/o Roche Glycart AG, Wagistrasse 10, 8952 Schlieren (CH). (74) Agent: KLOSTERMEYER RAUBER, Doerte; Gren- zacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) GO (54) Title: BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO PD1 AND LAG3 0 (57) : The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 \" and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these 0 molecules and to methods of using the same.
SG11201909154S 2017-04-05 2018-04-03 Bispecific antibodies specifically binding to pd1 and lag3 SG11201909154SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17165125 2017-04-05
PCT/EP2018/058382 WO2018185043A1 (en) 2017-04-05 2018-04-03 Bispecific antibodies specifically binding to pd1 and lag3

Publications (1)

Publication Number Publication Date
SG11201909154SA true SG11201909154SA (en) 2019-10-30

Family

ID=58489657

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909154S SG11201909154SA (en) 2017-04-05 2018-04-03 Bispecific antibodies specifically binding to pd1 and lag3

Country Status (32)

Country Link
US (2) US11285207B2 (en)
EP (2) EP4516809A3 (en)
JP (3) JP6997212B2 (en)
KR (2) KR102346336B1 (en)
CN (2) CN116375876A (en)
AR (1) AR111361A1 (en)
AU (1) AU2018247794B2 (en)
CA (1) CA3052532A1 (en)
CL (1) CL2019002620A1 (en)
CO (1) CO2019009076A2 (en)
CR (1) CR20190435A (en)
DK (1) DK3606955T3 (en)
ES (1) ES3000582T3 (en)
FI (1) FI3606955T3 (en)
HR (1) HRP20241775T1 (en)
HU (1) HUE069809T2 (en)
IL (1) IL268527B2 (en)
LT (1) LT3606955T (en)
MA (1) MA49038B1 (en)
MX (1) MX2019011910A (en)
MY (1) MY199406A (en)
PE (1) PE20191463A1 (en)
PH (1) PH12019502282A1 (en)
PL (1) PL3606955T3 (en)
PT (1) PT3606955T (en)
RS (1) RS66357B1 (en)
SG (1) SG11201909154SA (en)
SI (1) SI3606955T1 (en)
SM (1) SMT202500002T1 (en)
TW (2) TWI690538B (en)
UA (1) UA128451C2 (en)
WO (1) WO2018185043A1 (en)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018000768A2 (en) 2015-07-13 2018-09-25 Cytomx Therapeutics Inc anti-pd-1 antibodies, activatable anti-pd-1 antibodies and methods of use
ES2886569T3 (en) 2015-10-02 2021-12-20 Hoffmann La Roche Bispecific antibodies specific for PD1 and TIM3
IL300122A (en) 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc PD1 and/or LAG3 Binders
EP3458485B1 (en) 2016-05-19 2021-12-29 The General Hospital Corporation Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity
JP7426825B2 (en) 2017-04-03 2024-02-02 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Immunoconjugate of anti-PD-1 antibody and mutant IL-2 or IL-15
TWI690538B (en) 2017-04-05 2020-04-11 瑞士商赫孚孟拉羅股份公司 Bispecific antibodies specifically binding to pd1 and lag3
PE20210256A1 (en) * 2017-04-05 2021-02-10 Hoffmann La Roche ANTI-LAG3 ANTIBODIES
MA50102A (en) 2017-11-14 2020-07-15 Univ Virginia Patent Foundation COMPOSITIONS AND METHODS OF MANUFACTURING AND USE OF BISPECIFIC ANTIBODIES
CN111542543B (en) * 2017-12-28 2023-12-22 南京传奇生物科技有限公司 Antibodies against PD-L1 and its variants
CN111836630A (en) * 2018-01-05 2020-10-27 希望之城 Multispecific ligand conjugates
US20200354457A1 (en) * 2018-01-31 2020-11-12 Hoffmann-La Roche Inc. Bispecific antibodies comprising an antigen-binding site binding to lag3
AR114284A1 (en) 2018-04-13 2020-08-12 Hoffmann La Roche HER2 TARGETING ANTIGEN BINDING MOLECULES COMPOSING 4-1BBL
US20210238287A1 (en) 2018-07-26 2021-08-05 Bristol-Myers Squibb Company LAG-3 Combination Therapy for the Treatment of Cancer
PL3866850T3 (en) 2018-10-19 2024-10-14 Bristol-Myers Squibb Company Combination therapy for melanoma
JP2022511437A (en) 2018-11-26 2022-01-31 デバイオファーム インターナショナル エス．エー． Combined treatment of HIV infection
EP3898682A1 (en) 2018-12-21 2021-10-27 F. Hoffmann-La Roche AG Tumor-targeted agonistic cd28 antigen binding molecules
CN113924311A (en) * 2019-01-07 2022-01-11 印希比股份有限公司 Polypeptides comprising modified IL-2 polypeptides and uses thereof
WO2020206169A1 (en) 2019-04-02 2020-10-08 Kupper Thomas S Methods for identifying progression of a primary melanoma
JP2022530496A (en) * 2019-04-26 2022-06-29 ウーシー バイオロジクス アイルランド リミテッド Bispecific antibodies to PD-1 and LAG-3
AU2020273903B2 (en) 2019-05-14 2024-05-09 Progen Co., Ltd. Novel modified immunoglobulin Fc-fusion protein and use thereof
WO2020256868A1 (en) * 2019-05-16 2020-12-24 Trustees Of Boston University Immune system modulators for the treatment of squamous lung premalignancy
KR20220024636A (en) 2019-06-19 2022-03-03 에프. 호프만-라 로슈 아게 Methods of Generation of Multivalent, Multispecific Antibody Expression Cells by Targeted Integration of Multiple Expression Cassettes of Defined Tissues
AU2020294880B2 (en) * 2019-06-19 2024-05-02 F. Hoffmann-La Roche Ag Method for the generation of a protein expressing cell by targeted integration using Cre mRNA
KR20220010019A (en) 2019-06-19 2022-01-25 에프. 호프만-라 로슈 아게 Methods of Generating Bivalent Bispecific Antibody Expression Cells by Targeted Integration of Multiple Expression Cassettes in Defined Tissues
JP2022546922A (en) * 2019-07-30 2022-11-10 メルク・シャープ・アンド・ドーム・エルエルシー Anti-PD-1/LAG3/TIGIT trispecific antibody and anti-PD-1/LAG3 bispecific antibody
EP4031873A1 (en) 2019-09-22 2022-07-27 Bristol-Myers Squibb Company Quantitative spatial profiling for lag-3 antagonist therapy
WO2021092221A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
WO2021092220A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
EP4054723A1 (en) 2019-11-08 2022-09-14 Bristol-Myers Squibb Company Lag-3 antagonist therapy for melanoma
JP2023507848A (en) * 2019-12-23 2023-02-27 マクロジェニクス，インコーポレーテッド Therapies for the treatment of cancer
WO2021154073A1 (en) * 2020-01-29 2021-08-05 Merus N.V. Means and method for modulating immune cell engaging effects.
KR20220139915A (en) 2020-02-06 2022-10-17 브리스톨-마이어스 스큅 컴퍼니 IL-10 and its uses
WO2021225423A1 (en) 2020-05-07 2021-11-11 인터올리고 주식회사 Novel nucleic acid ligand, and method for identifyng same
US20230265188A1 (en) 2020-08-28 2023-08-24 Bristol-Myers Squibb Company Lag-3 antagonist therapy for hepatocellular carcinoma
US20230406949A1 (en) * 2020-10-13 2023-12-21 Board Of Regents, The University Of Texas System Combinatorial immunotherapeutic methods and compositions for pancreatic ductal adenocarcinoma treatment
KR20230093282A (en) 2020-10-23 2023-06-27 브리스톨-마이어스 스큅 컴퍼니 LAG-3 antagonist therapy for lung cancer
CN114621345B (en) * 2020-12-10 2022-11-29 北京东方百泰生物科技股份有限公司 anti-LAG-3 monoclonal antibody, antigen binding fragment thereof and application thereof
HRP20250628T1 (en) 2020-12-28 2025-07-18 Bristol-Myers Squibb Company MIXTURES OF ANTIBODIES AND METHODS OF USING THEM
MX2023007650A (en) 2020-12-28 2023-09-11 Bristol Myers Squibb Co Subcutaneous administration of pd1/pd-l1 antibodies.
AU2022206061A1 (en) 2021-01-06 2023-07-06 F. Hoffmann-La Roche Ag Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody
WO2022155263A2 (en) * 2021-01-12 2022-07-21 Askgene Pharma Inc. Chimeric molecules comprising il-12 agonist polypeptide
JP2024514245A (en) 2021-03-29 2024-03-29 ジュノー セラピューティクス インコーポレイテッド Methods for dosing and treatment using a combination of checkpoint inhibitor therapy and CAR T cell therapy
US20240285740A1 (en) 2021-05-12 2024-08-29 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating cancer
JP7660823B2 (en) * 2021-05-18 2025-04-14 スージョウ カノヴァ バイオファーマシューティカル カンパニーリミテッド Anti-PD-1 Polypeptides and Uses Thereof
CN115536749A (en) * 2021-06-29 2022-12-30 三生国健药业（上海）股份有限公司 Trispecific antibodies, methods of making and uses thereof
EP4363449A2 (en) * 2021-07-02 2024-05-08 Genentech, Inc. Methods and compositions for treating cancer
JP2024529451A (en) * 2021-07-28 2024-08-06 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Methods and Compositions for Treating Cancer
WO2023014196A1 (en) 2021-08-06 2023-02-09 인터올리고 주식회사 Pharmaceutical composition for preventing or treating triple-negative breast cancer, comprising oligonucleotide as active ingredient
EP4410835A4 (en) * 2021-09-29 2025-09-24 Akeso Biopharma Inc ANTI-LAG3 ANTIBODIES, PHARMACEUTICAL COMPOSITION AND USE
KR20230060546A (en) * 2021-10-22 2023-05-04 상트네어바이오사이언스 주식회사 ANTIGEN BINDING PROTEINS WITH TWO Fc DOMAINS AND USE THEREOF
US20240417473A1 (en) 2021-10-29 2024-12-19 Bristol-Myers Squibb Company Lag-3 antagonist therapy for hematological cancer
AU2023213937A1 (en) 2022-01-26 2024-07-18 Bristol-Myers Squibb Company Combination therapy for hepatocellular carcinoma
IL314713A (en) 2022-02-25 2024-10-01 Bristol Myers Squibb Co Combination therapy for colorectal carcinoma
WO2023168404A1 (en) 2022-03-04 2023-09-07 Bristol-Myers Squibb Company Methods of treating a tumor
WO2023215560A1 (en) 2022-05-05 2023-11-09 Atoosa Corporation Tumor cell/immune cell multivalent receptor engager – bio-nanoparticle (timre-bnp)
EP4531916A1 (en) 2022-06-02 2025-04-09 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
WO2024072893A1 (en) * 2022-09-28 2024-04-04 Incyte Corporation Anti-pd-1/lag-3 bispecific antibodies and uses thereof
KR20250123912A (en) 2022-12-21 2025-08-18 브리스톨-마이어스 스큅 컴퍼니 Combination therapy for lung cancer
EP4658687A1 (en) 2023-01-31 2025-12-10 University of Rochester Immune checkpoint blockade therapy for treating staphylococcus aureus infections
WO2024163009A1 (en) 2023-01-31 2024-08-08 Genentech, Inc. Methods and compositions for treating urothelial bladder cancer
WO2024163494A1 (en) 2023-01-31 2024-08-08 F. Hoffmann-La Roche Ag Methods and compositions for treating non-small cell lung cancer and triple-negative breast cancer
WO2024188965A1 (en) 2023-03-13 2024-09-19 F. Hoffmann-La Roche Ag Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody
WO2024196952A1 (en) 2023-03-20 2024-09-26 Bristol-Myers Squibb Company Tumor subtype assessment for cancer therapy
AU2024247361A1 (en) * 2023-03-29 2025-10-16 Akeso Biopharma Co., Ltd. Anti-lag3 antibody, pharmaceutical composition, and use
US20250215087A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg depleting agent
WO2025184208A1 (en) 2024-02-27 2025-09-04 Bristol-Myers Squibb Company Anti-ceacam5 antibodies and uses thereof
WO2025184211A1 (en) 2024-02-27 2025-09-04 Bristol-Myers Squibb Company Anti-ceacam5 antibody drug conjugates
WO2025245489A1 (en) 2024-05-24 2025-11-27 Bristol-Myers Squibb Company Treatment of tumors in subjects having fgl-1 positive samples

Family Cites Families (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
ES2052027T5 (en) 1988-11-11 2005-04-16 Medical Research Council IMMUNOGLOBULINE VARIABLE DOMAIN SEQUENCE CLONING.
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
DE69233254T2 (en) 1991-06-14 2004-09-16 Genentech, Inc., South San Francisco Humanized Heregulin antibody
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
JP3951062B2 (en) 1991-09-19 2007-08-01 ジェネンテック・インコーポレーテッド Expression of antibody fragments with cysteine present at least as a free thiol in E. coli for the production of bifunctional F (ab ') 2 antibodies
FI941572A7 (en) 1991-10-07 1994-05-27 Oncologix Inc Combination and method of use of anti-erbB-2 monoclonal antibodies
DE69334351D1 (en) 1992-02-06 2011-05-12 Novartis Vaccines & Diagnostic Biosynthetic binding protein for tumor markers
US5747654A (en) 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US6066322A (en) 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
DE69632967T2 (en) 1996-11-29 2005-08-11 Applied Research Systems Ars Holding N.V. Method of preventing graft rejection in transplantation and producing a universal gene therapy host cell using lymphocyte activating gene (LAG-3)
ATE299938T1 (en) 1997-05-02 2005-08-15 Genentech Inc A METHOD FOR PRODUCING MULTI-SPECIFIC ANTIBODIES THAT POSSESS HETEROMULTIMER AND COMMON COMPONENTS
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
JP2002506353A (en) 1997-06-24 2002-02-26 ジェネンテック・インコーポレーテッド Methods and compositions for galactosylated glycoproteins
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
DE19742706B4 (en) 1997-09-26 2013-07-25 Pieris Proteolab Ag lipocalin muteins
AU759779B2 (en) 1997-10-31 2003-05-01 Genentech Inc. Methods and compositions comprising glycoprotein glycoforms
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
DK2180007T4 (en) 1998-04-20 2017-11-27 Roche Glycart Ag Glycosylation technique for antibodies to enhance antibody-dependent cell cytotoxicity
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
MX353234B (en) 1999-01-15 2018-01-08 Genentech Inc Polypeptide variants with altered effector function.
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
DE60022369T2 (en) 1999-10-04 2006-05-18 Medicago Inc., Sainte Foy PROCESS FOR REGULATING THE TRANSCRIPTION OF FOREIGN GENES IN THE PRESENCE OF NITROGEN
PL357939A1 (en) 2000-04-11 2004-08-09 Genentech, Inc. Multivalent antibodies and uses therefor
CA2411374C (en) 2000-06-29 2012-10-30 Abbott Laboratories Dual specificity antibodies and methods of making and using
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
WO2003011878A2 (en) 2001-08-03 2003-02-13 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
CA2463879C (en) 2001-10-25 2012-12-04 Genentech, Inc. Glycoprotein compositions
EP1456652A4 (en) 2001-11-13 2005-11-02 Dana Farber Cancer Inst Inc AGENTS MODULATING IMMUNE CELL ACTIVITY AND METHODS OF USE THEREOF
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
WO2003063792A2 (en) 2002-01-30 2003-08-07 The Brigham And Women's Hospital, Inc. Compositions and methods related to tim-3, a th1-specific cell surface molecule
CA2488441C (en) 2002-06-03 2015-01-27 Genentech, Inc. Synthetic antibody phage libraries
EP2243493A1 (en) 2002-07-03 2010-10-27 Ono Pharmaceutical Co., Ltd. Immunopotentiative composition
PL210545B1 (en) 2002-10-10 2012-01-31 Merck Patent Gmbh Pharmaceutical compositions directed to erb-b1 receptors
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
RS20100366A (en) 2002-12-16 2011-04-30 Genentech, Inc. Immunoglobulin variants and uses thereof
CN1753912B (en) 2002-12-23 2011-11-02 惠氏公司 Anti-PD-1 antibodies and uses thereof
KR20050107399A (en) 2003-01-23 2005-11-11 오노 야꾸힝 고교 가부시키가이샤 Substance specific to human pd-1
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
RU2005127664A (en) 2003-02-06 2006-09-10 Микромет Аг (De) TRIMER POLYPEPTIDE CONSTRUCTION Inducing a Prolonged T-CELL RESPONSE
AU2004217526B2 (en) 2003-02-28 2010-02-04 St. Jude Children's Research Hospital Inc. T cell regulation
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
AU2003272065A1 (en) 2003-04-03 2004-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof
ES2319426T3 (en) 2003-07-04 2009-05-07 Affibody Ab POLYPEPTIDES PRESENTING AFFINITY OF UNION BY HER-2.
AU2003275958A1 (en) 2003-08-25 2005-03-10 Pieris Proteolab Ag Muteins of tear lipocalin
KR101501870B1 (en) 2003-08-27 2015-03-12 옵쏘테크 코포레이션 Combination therapy for the treatment of ocular neovascular disorders
HUE042914T2 (en) 2003-11-05 2019-07-29 Roche Glycart Ag CD20 antibodies with increased fc receptor binding affinity and effector function
AU2004296376B2 (en) 2003-12-05 2010-03-04 Bristol-Myers Squibb Company Inhibitors of type 2 vascular endothelial growth factor receptors
KR20050082389A (en) 2004-02-18 2005-08-23 메덱스젠 주식회사 Pharmaceutical composition for treatment of transplantation rejection comprising concatameric immunoadhesin
BRPI0516284A (en) 2004-09-23 2008-09-02 Genentech Inc cysteine-constructed antibody, method of selecting antibodies, drug-antibody conjugated compounds, pharmaceutical composition, method for killing or inhibiting tumor cell proliferation, methods of inhibiting cell proliferation and tumor cell growth, manufactured article and method to produce a compound
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
TWI671403B (en) 2005-03-31 2019-09-11 中外製藥股份有限公司 Method for controlling controlled assembly of polypeptide
MX2007013978A (en) 2005-05-09 2008-02-22 Ono Pharmaceutical Co MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND METHODS FOR CANCER TREATMENT USING ANTI-PD-1 ANTIBODIES ONLY OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS.
NZ593388A (en) 2005-06-08 2012-08-31 Dana Farber Cancer Inst Inc Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1) pathway
JP2006345852A (en) 2005-06-16 2006-12-28 Virxsys Corp Antibody complex
CN105330741B (en) 2005-07-01 2023-01-31 E.R.施贵宝&圣斯有限责任公司 Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US8623356B2 (en) 2005-11-29 2014-01-07 The University Of Sydney Demibodies: dimerization-activated therapeutic agents
PT1999154E (en) 2006-03-24 2013-01-24 Merck Patent Gmbh Engineered heterodimeric protein domains
CN101490085A (en) 2006-06-12 2009-07-22 特鲁比昂药品公司 Single-chain multivalent binding proteins with effector function
MX363905B (en) 2006-06-12 2019-04-08 Aptevo Res & Development Llc Single-chain multivalent binding proteins with effector function.
WO2007147901A1 (en) 2006-06-22 2007-12-27 Novo Nordisk A/S Production of bispecific antibodies
EP2102241A2 (en) 2006-12-15 2009-09-23 Ablynx N.V. Amino acid sequences that modulate the interaction between cells of the immune system
CN103536915A (en) 2006-12-27 2014-01-29 埃默里大学 Compositions and methods for the treatment of infections and tumors
DE102007001370A1 (en) 2007-01-09 2008-07-10 Curevac Gmbh RNA-encoded antibodies
EP1958957A1 (en) 2007-02-16 2008-08-20 NascaCell Technologies AG Polypeptide comprising a knottin protein moiety
US9244059B2 (en) 2007-04-30 2016-01-26 Immutep Parc Club Orsay Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
WO2009015917A2 (en) 2007-05-14 2009-02-05 F. Hoffmann-La Roche Ag Dihydroquinone and dihydronaphthridine inhibitors of jnk
KR101562580B1 (en) 2007-06-18 2015-10-22 머크 샤프 앤 도메 비.브이. Antibodies to human programmed death receptor PD-1
US8828666B2 (en) 2007-06-18 2014-09-09 Chugai Seiyaku Kabushiki Kaisha Method for measuring bonding activity of antibody which mimics antibody-dependent cell medicated cytotoxic activity
WO2009014708A2 (en) 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
EP2195347A1 (en) 2007-08-17 2010-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for treating and diagnosing hematologic malignancies
CA2703947C (en) 2007-10-26 2018-12-04 Governing Council Of The University Of Toronto Therapeutic and diagnostic methods using tim-3
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
AU2009204501B2 (en) 2008-01-07 2015-02-12 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
ES2639857T3 (en) 2008-02-11 2017-10-30 Cure Tech Ltd. Monoclonal antibodies for tumor treatment
WO2009114335A2 (en) 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
KR101001360B1 (en) 2008-06-16 2010-12-14 (주)기가레인 Printed circuit board electrically connected to the ground of electronic equipment
HUE025236T2 (en) 2008-07-21 2016-03-29 Apogenix Gmbh Tnfsf single chain molecules
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
WO2010027827A2 (en) 2008-08-25 2010-03-11 Amplimmune, Inc. Targeted costimulatory polypeptides and methods of use to treat cancer
NZ591130A (en) 2008-08-25 2012-09-28 Amplimmune Inc Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof
US9181342B2 (en) 2008-09-12 2015-11-10 Isis Innovation Limited PD-1 specific antibodies and uses thereof
US8927697B2 (en) 2008-09-12 2015-01-06 Isis Innovation Limited PD-1 specific antibodies and uses thereof
CN102264762B (en) 2008-09-26 2018-03-27 达纳-法伯癌症研究公司 Human anti-PD-1, PD-L1 and PD-L2 antibodies and uses thereof
MX2011005691A (en) 2008-11-28 2011-07-20 Univ Emory Methods for the treatment of infections and tumors.
JP5569946B2 (en) 2009-01-26 2014-08-13 国立大学法人 岡山大学 Immunosuppressants and preventive and therapeutic agents for autoimmune diseases
US8741295B2 (en) 2009-02-09 2014-06-03 Universite De La Mediterranee PD-1 antibodies and PD-L1 antibodies and uses thereof
US20110313129A1 (en) 2009-02-11 2011-12-22 Life Technologies Corporation Large stokes shift dyes
PE20120591A1 (en) 2009-04-02 2012-05-23 Roche Glycart Ag MULTI-SPECIFIC ANTIBODIES INCLUDING FULL-LENGTH ANTIBODIES AND SINGLE-CHAIN FAB FRAGMENTS
EP2417156B1 (en) 2009-04-07 2015-02-11 Roche Glycart AG Trivalent, bispecific antibodies
AU2010245011B2 (en) 2009-04-27 2015-09-03 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
CA2761233A1 (en) 2009-05-27 2010-12-02 F. Hoffmann-La Roche Ag Tri- or tetraspecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
JP5856073B2 (en) 2009-12-29 2016-02-09 エマージェント プロダクト デベロップメント シアトル， エルエルシー RON binding construct and method of use thereof
PT2542590T (en) 2010-03-05 2017-08-31 Univ Johns Hopkins COMPOSITIONS AND METHODS FOR DIRECTED IMMUNOMODULATOR ANTIBODIES AND FUSION PROTEINS
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
CA2791930A1 (en) 2010-03-11 2011-09-15 Kerry Louise Tyson Pd-1 antibody
WO2011143545A1 (en) 2010-05-14 2011-11-17 Rinat Neuroscience Corporation Heterodimeric proteins and methods for producing and purifying them
AU2011262758B8 (en) 2010-06-11 2014-09-04 Kyowa Kirin Co., Ltd. Anti-tim-3 antibody
JP2013532153A (en) 2010-06-18 2013-08-15 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Bispecific antibodies against TIM-3 and PD-1 for immunotherapy against chronic immune disease
NZ703653A (en) 2010-08-13 2016-09-30 Roche Glycart Ag Anti-fap antibodies and methods of use
MX352929B (en) 2010-11-05 2017-12-13 Zymeworks Inc DESIGN OF STABLE HETERODIMERIC ANTIBODIES WITH MUTATIONS IN THE DOMAIN Fc.
MX340671B (en) 2011-02-10 2016-07-20 Roche Glycart Ag Mutant interleukin-2 polypeptides.
TR201815420T4 (en) 2011-03-29 2018-11-21 Roche Glycart Ag Antibody fc variants.
CA2831820C (en) 2011-04-01 2021-05-25 Universitat Stuttgart Recombinant tnf ligand family member polypeptides with antibody binding domain and uses thereof
WO2012145493A1 (en) 2011-04-20 2012-10-26 Amplimmune, Inc. Antibodies and other molecules that bind b7-h1 and pd-1
WO2013006490A2 (en) 2011-07-01 2013-01-10 Cellerant Therapeutics, Inc. Antibodies that specifically bind to tim3
FR2977674B1 (en) 2011-07-06 2015-08-14 Cisbio Bioassays IMPROVED METHOD OF DETECTING AND / OR QUANTIFYING AN ANALYTE PRESENT AT THE SURFACE OF A CELL
EP2543680A1 (en) 2011-07-07 2013-01-09 Centre National de la Recherche Scientifique Multispecific mutated antibody Fab fragments
BR112013032552A2 (en) 2011-07-24 2017-12-12 Curetech Ltd humanized immunomodulatory monoclonal antibody variants
SG2014012298A (en) 2011-08-11 2014-06-27 Medarex Llc Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
KR101721301B1 (en) 2011-08-23 2017-03-29 로슈 글리카트 아게 Bispecific antigen binding molecules
FR2980271B1 (en) 2011-09-16 2013-10-11 Cisbio Bioassays METHOD FOR DETERMINING GLYCOSYLATION OF ANTIBODY
RS60499B1 (en) 2011-12-20 2020-08-31 Medimmune Llc Modified polypeptides for bispecific antibody scaffolds
CA2859268A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
WO2013141372A1 (en) 2012-03-22 2013-09-26 三井造船株式会社 Fret measurement device and fret measurement method
ES2740749T3 (en) 2012-04-20 2020-02-06 Merus Nv Methods and means for the production of Ig-like heterodimeric molecules
MY174248A (en) 2012-04-30 2020-04-01 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same
AR091649A1 (en) 2012-07-02 2015-02-18 Bristol Myers Squibb Co OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
DK3495387T3 (en) 2012-07-13 2021-11-08 Roche Glycart Ag Bispecific anti-VEGF / anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases
EP3434695B1 (en) 2012-08-07 2020-12-02 Roche Glycart AG Improved immunotherapy
US9771573B2 (en) 2012-10-03 2017-09-26 Zymeworks Inc. Methods of quantitating heavy and light chain polypeptide pairs
NZ708182A (en) 2013-02-26 2019-08-30 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
ES2808654T3 (en) 2013-03-15 2021-03-01 Glaxosmithkline Ip Dev Ltd Anti-LAG-3 binding proteins
HRP20210122T1 (en) 2013-05-02 2021-04-16 Anaptysbio, Inc. Antibodies directed against programmed death-1 (pd-1)
KR20250007687A (en) 2013-07-16 2025-01-14 제넨테크, 인크. Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
HRP20231437T1 (en) 2013-08-08 2024-02-16 Cytune Pharma Il-15 and il-15ralpha sushi domain based on modulokines
KR20210141789A (en) 2013-09-20 2021-11-23 브리스톨-마이어스 스큅 컴퍼니 Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors
US10570204B2 (en) 2013-09-26 2020-02-25 The Medical College Of Wisconsin, Inc. Methods for treating hematologic cancers
RU2016115866A (en) 2013-10-11 2017-11-16 Ф. Хоффманн-Ля Рош Аг MULTI-SPECIFIC ANTIBODIES WITH EXCHANGED DOMAINS AND SAME VARIABLE DOMAINS OF EASY CHAIN
SG10201804945WA (en) 2013-12-12 2018-07-30 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
JP2017501167A (en) 2013-12-17 2017-01-12 ジェネンテック， インコーポレイテッド Combination therapy comprising OX40 binding agonist and PD-1 axis binding antagonist
CA2931986A1 (en) * 2014-01-15 2015-07-23 F. Hoffmann-La Roche Ag Fc-region variants with modified fcrn- and maintained protein a-binding properties
US10794898B2 (en) 2014-01-17 2020-10-06 Regents Of The University Of Minnesota High-throughput, high-precision methods for detecting protein structural changes in living cells
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
JOP20200094A1 (en) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody molecules to pd-1 and uses thereof
KR20160106762A (en) 2014-01-28 2016-09-12 브리스톨-마이어스 스큅 컴퍼니 Anti-lag-3 antibodies to treat hematological malignancies
PH12016501545B1 (en) * 2014-03-14 2023-12-06 Immutep Sas Antibody molecules to lag-3 and uses thereof
UA117289C2 (en) 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг MULTISPECIFIC ANTIBODY
KR20160141857A (en) 2014-04-25 2016-12-09 제넨테크, 인크. Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab
CN104009998B (en) 2014-06-09 2017-11-17 宇龙计算机通信科技(深圳)有限公司 Server and data transmission method
TWI693232B (en) * 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof
SMT202400235T1 (en) 2014-08-04 2024-07-09 Hoffmann La Roche Bispecific t cell activating antigen binding molecules
JO3663B1 (en) 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
JP2017533207A (en) * 2014-10-23 2017-11-09 ファイヴ プライム セラピューティクス インク SLAMF1 antagonist and use thereof
GB201419084D0 (en) 2014-10-27 2014-12-10 Agency Science Tech & Res Anti-PD-1 antibodies
PL3215532T3 (en) 2014-11-06 2020-03-31 F. Hoffmann-La Roche Ag Anti-TIM3 antibodies and methods of their use
MX391388B (en) 2014-11-14 2025-03-21 Hoffmann La Roche ANTIGEN-BINDING MOLECULES THAT COMPRISE A LIGAND TRIMER FROM THE TNF FAMILY.
HRP20201747T1 (en) 2014-11-20 2020-12-25 F. Hoffmann - La Roche Ag BISPECIFIC ANTIGEN BINDING MOLECULES ACTIVATING T-CELLS, AGAINST FOLR1 AND CD3
CN107206072B (en) 2014-11-20 2022-01-21 豪夫迈·罗氏有限公司 Combination therapy of the T cell activating bispecific antigen binding molecule CD3 ABD folate receptor 1(FolR1) and a PD-1 axis binding antagonist
TWI595006B (en) 2014-12-09 2017-08-11 禮納特神經系統科學公司 Anti-PD-1 antibodies and methods of using same
ES2881484T3 (en) 2014-12-22 2021-11-29 Pd 1 Acquisition Group Llc Anti-PD-1 antibodies
MA41463A (en) 2015-02-03 2017-12-12 Anaptysbio Inc ANTIBODIES DIRECTED AGAINST LYMPHOCYTE ACTIVATION GEN 3 (LAG-3)
TWI773646B (en) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 Lag-3-binding molecules and methods of use thereof
TWI773647B (en) 2015-06-23 2022-08-11 史隆凱特林紀念癌症中心 Novel pd-1 immune modulating agents
US9902772B2 (en) 2015-07-22 2018-02-27 Sorrento Therapeutics, Inc. Antibody therapeutics that bind LAG3
CN108699145A (en) 2015-09-02 2018-10-23 伊缪泰普有限公司 anti-LAG-3 antibody
ES2886569T3 (en) 2015-10-02 2021-12-20 Hoffmann La Roche Bispecific antibodies specific for PD1 and TIM3
PE20181092A1 (en) 2015-10-02 2018-07-09 Hoffmann La Roche ANTI-PD1 ANTIBODIES AND METHODS OF USE
EP3356821B1 (en) 2015-10-02 2019-10-23 H. Hoffnabb-La Roche Ag Cellular based fret assay for the determination of simultaneous binding
RU2018116402A (en) 2015-10-07 2019-11-07 Ф. Хоффманн-Ля Рош Аг BESPECIFIC ANTIBODIES FOUR PRINCIPLES REGARDING THE COSTIMULATORY TNF RECEPTOR
EP3368568B1 (en) 2015-10-29 2022-04-06 F. Hoffmann-La Roche AG Anti-variant fc-region antibodies and methods of use
MX377531B (en) 2015-11-03 2025-03-10 Hoffmann La Roche COMBINATION THERAPY OF AN HBV CAPSID ASSEMBLY INHIBITOR AND AN INTERFERON.
WO2017096026A1 (en) 2015-12-02 2017-06-08 Stcube, Inc. Antibodies specific to glycosylated pd-1 and methods of use thereof
WO2017097728A1 (en) 2015-12-10 2017-06-15 F. Hoffmann-La Roche Ag Bridged piperidine derivatives
US12059474B2 (en) 2016-03-29 2024-08-13 Stcube & Co., Inc. Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins
JP7285076B2 (en) 2016-05-11 2023-06-01 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Antigen-binding molecule comprising a TNF family ligand trimer and a tenascin-binding portion
EP3243836A1 (en) 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG C-terminally fused tnf family ligand trimer-containing antigen binding molecules
EP3243832A1 (en) 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
JP7426825B2 (en) 2017-04-03 2024-02-02 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Immunoconjugate of anti-PD-1 antibody and mutant IL-2 or IL-15
EP3606947B1 (en) 2017-04-03 2022-12-21 F. Hoffmann-La Roche AG Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody
TWI690538B (en) 2017-04-05 2020-04-11 瑞士商赫孚孟拉羅股份公司 Bispecific antibodies specifically binding to pd1 and lag3
PE20210256A1 (en) 2017-04-05 2021-02-10 Hoffmann La Roche ANTI-LAG3 ANTIBODIES
JP2020516604A (en) 2017-04-05 2020-06-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Anti-cancer combination therapy
US11939380B2 (en) 2017-04-05 2024-03-26 Les Laboratoires Servier Combination therapies targeting PD-1, TIM-3, and LAG-3

Also Published As

Publication number Publication date
WO2018185043A1 (en) 2018-10-11
JP6997212B2 (en) 2022-02-04
UA128451C2 (en) 2024-07-17
CL2019002620A1 (en) 2020-01-10
PL3606955T3 (en) 2025-02-24
KR102408873B1 (en) 2022-06-15
US11285207B2 (en) 2022-03-29
AR111361A1 (en) 2019-07-03
KR102346336B1 (en) 2022-01-04
LT3606955T (en) 2025-01-27
PT3606955T (en) 2025-01-09
RS66357B1 (en) 2025-01-31
AU2018247794A1 (en) 2019-08-22
MA49038B1 (en) 2025-01-31
EP3606955A1 (en) 2020-02-12
RU2019134227A (en) 2021-05-05
PE20191463A1 (en) 2019-10-16
KR20220003130A (en) 2022-01-07
ES3000582T3 (en) 2025-02-28
TW202030207A (en) 2020-08-16
JP2022033742A (en) 2022-03-02
AU2018247794B2 (en) 2025-04-17
CN116375876A (en) 2023-07-04
EP4516809A2 (en) 2025-03-05
CR20190435A (en) 2019-11-12
MA49038A (en) 2020-02-12
TWI690538B (en) 2020-04-11
TW201841941A (en) 2018-12-01
PH12019502282A1 (en) 2020-07-06
HUE069809T2 (en) 2025-04-28
JP7304921B2 (en) 2023-07-07
CO2019009076A2 (en) 2019-08-30
US20220387586A1 (en) 2022-12-08
FI3606955T3 (en) 2025-01-08
KR20190126356A (en) 2019-11-11
BR112019019821A2 (en) 2020-04-22
SMT202500002T1 (en) 2025-03-12
IL268527A (en) 2019-09-26
TWI747215B (en) 2021-11-21
JP2023138967A (en) 2023-10-03
IL268527B1 (en) 2023-11-01
CA3052532A1 (en) 2018-10-11
US20180326054A1 (en) 2018-11-15
MY199406A (en) 2023-10-25
CN110506059B (en) 2023-01-17
SI3606955T1 (en) 2025-03-31
CN110506059A (en) 2019-11-26
EP3606955B1 (en) 2024-11-06
EP4516809A3 (en) 2025-09-03
HRP20241775T1 (en) 2025-02-28
IL268527B2 (en) 2024-03-01
RU2019134227A3 (en) 2021-06-10
DK3606955T3 (en) 2025-01-13
MX2019011910A (en) 2020-01-09
JP2020516252A (en) 2020-06-11

Similar Documents

Publication Publication Date Title
SG11201909154SA (en) Bispecific antibodies specifically binding to pd1 and lag3
SG11201909344SA (en) Anti-lag3 antibodies
SG11201908787WA (en) Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap
SG11201909205YA (en) Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
SG11201908796XA (en) Improved antigen binding receptors
SG11201908813QA (en) Anti-sirp alpha antibodies
SG11201908088RA (en) Antibodies against pd-l1
SG11201908719QA (en) Biomarkers and car t cell therapies with enhanced efficacy
SG11201810076WA (en) Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
SG11201907753TA (en) Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
SG11201900885VA (en) Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
SG11201908784TA (en) Improved antigen binding receptor formats
SG11201903857UA (en) Antibodies to pd-1 and uses thereof
SG11201907580SA (en) Combination therapies for treatment of bcma-related cancers and autoimmune disorders
SG11201807770RA (en) Sequence arrangements and sequences for neoepitope presentation
SG11201907364WA (en) Anti-tryptase antibodies, compositions thereof, and uses thereof
SG11201908127WA (en) Method for producing multispecific antibodies
SG11201809115RA (en) Implementing logic gate functionality using a blockchain
SG11201810149VA (en) Anti hla-g specific antibodies
SG11201805709RA (en) Anti-pro/latent myostatin antibodies and methods of use thereof
SG11201809620UA (en) The contorsbody - a single chain target binder
SG11201805420SA (en) Antibodies and conjugates thereof
SG11201909218RA (en) Antibodies binding to steap-1
SG11201908056QA (en) Anti-par2 antibodies and uses thereof
SG11201908238SA (en) Anti-c5 antibodies and uses thereof