SG11201505796TA - Heterocyclic amides as kinase inhibitors - Google Patents

Heterocyclic amides as kinase inhibitors

Info

Publication number: SG11201505796TA
Authority: SG; Singapore
Prior art keywords: kinase inhibitors; heterocyclic amides; amides; heterocyclic; kinase
Prior art date: 2013-02-15

Application number

SG11201505796TA

Other languages

English (en)

Inventor

Deepak Bandyopadhyay

Patrick M Eidam

Peter J Gough

Philip Anthony Harris

Jae U Jeong

Jianxing Kang

Bryan Wayne King

Shah Ami Lakdawala

Jr Robert W Marquis

Lara Kathryn Leister

Attiq Rahman

Joshi M Ramanjulu

Clark A Sehon

Jr Robert Singhaus

Daohua Zhang

Original Assignee

Glaxosmithkline Ip Dev Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-02-15

Filing date

2014-02-14

Publication date

2015-08-28

2014-02-14 Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd

2015-08-28 Publication of SG11201505796TA publication Critical patent/SG11201505796TA/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)

SG11201505796TA 2013-02-15 2014-02-14 Heterocyclic amides as kinase inhibitors SG11201505796TA (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201361765664P	2013-02-15	2013-02-15
US201361790044P	2013-03-15	2013-03-15
PCT/IB2014/059004 WO2014125444A1 (en)	2013-02-15	2014-02-14	Heterocyclic amides as kinase inhibitors

Publications (1)

Publication Number	Publication Date
SG11201505796TA true SG11201505796TA (en)	2015-08-28

Family

ID=50151350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201505796TA SG11201505796TA (en)	2013-02-15	2014-02-14	Heterocyclic amides as kinase inhibitors

Country Status (38)

Country	Link
US (6)	US9556152B2 (zh)
EP (4)	EP3342771B1 (zh)
JP (3)	JP6321045B2 (zh)
KR (2)	KR102228764B1 (zh)
CN (3)	CN105121432B (zh)
AU (1)	AU2014217453B2 (zh)
BR (4)	BR122017002949A2 (zh)
CA (1)	CA2900695C (zh)
CL (1)	CL2015002279A1 (zh)
CR (3)	CR20190512A (zh)
CY (2)	CY1120320T1 (zh)
DK (2)	DK3342771T3 (zh)
DO (3)	DOP2015000196A (zh)
EA (2)	EA028991B1 (zh)
ES (3)	ES2855135T3 (zh)
HK (1)	HK1249100A1 (zh)
HR (2)	HRP20180900T1 (zh)
HU (2)	HUE037763T2 (zh)
IL (3)	IL240280B (zh)
LT (2)	LT2956452T (zh)
MA (1)	MA44820B1 (zh)
MX (3)	MX360715B (zh)
MY (2)	MY178552A (zh)
NZ (1)	NZ628447A (zh)
PE (1)	PE20151752A1 (zh)
PH (4)	PH12015501675A1 (zh)
PL (2)	PL2956452T3 (zh)
PT (2)	PT3342771T (zh)
RS (2)	RS61439B1 (zh)
SG (1)	SG11201505796TA (zh)
SI (2)	SI2956452T1 (zh)
SM (2)	SMT202100083T1 (zh)
TR (1)	TR201808112T4 (zh)
TW (4)	TWI648274B (zh)
UA (1)	UA118259C2 (zh)
UY (1)	UY35330A (zh)
WO (1)	WO2014125444A1 (zh)
ZA (1)	ZA201505267B (zh)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI648274B (zh)	2013-02-15	2019-01-21	英商葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之雜環醯胺類（二）
US20170266199A1 (en)	2014-08-21	2017-09-21	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as rip1 kinase inhibitors as medicaments
EP3218371B1 (en) *	2014-11-14	2018-09-26	Boehringer Ingelheim International GmbH	Aryl and heteroaryl-fused tetrahydro-1,4-oxazepine amides as somatostatin receptor subtype 4 (sstr4) agonists
JP2017538712A (ja)	2014-12-11	2017-12-28	プレジデントアンドフェローズオブハーバードカレッジ	細胞壊死の抑制剤及びそれに関連する方法
CN107207485A (zh) *	2015-02-13	2017-09-26	葛兰素史密斯克莱知识产权发展有限公司	(S)‑5‑苄基‑N‑(5‑甲基‑4‑氧代‑2,3,4,5‑四氢苯并[b][1,4]氧氮杂环庚三烯‑3‑基)‑4H‑1,2,4‑三唑‑3‑甲酰胺的晶型
EP3265463B1 (en)	2015-03-02	2018-12-19	Apeiron Biologics AG	Bicyclic tetrahydrothiazepine derivatives useful for the treatment of neoplastic and/or infectious diseases
UY36680A (es) *	2015-05-19	2016-12-30	Glaxosmithkline Ip Dev Ltd	Amidas heterocíclicas como inhibidores de quinasa
KR20180030545A (ko) *	2015-06-22	2018-03-23	다이닛본 스미토모 세이야꾸 가부시끼가이샤	바이사이클릭 헤테로사이클릭 아미드 유도체
MY192762A (en) *	2015-07-02	2022-09-07	Hoffmann La Roche	Bicyclic lactams and methods of use thereof
SMT202200437T1 (it)	2015-07-22	2023-01-13	Enanta Pharm Inc	Derivati benzodiazepinaci come inibitori del rsv
EP3366684B1 (en)	2015-10-23	2020-09-02	Takeda Pharmaceutical Company Limited	Heterocyclic compound
CN108602809B (zh) *	2015-12-04	2022-09-30	戴纳立制药公司	异噁唑烷衍生的受体相互作用蛋白激酶1(ripk 1)的抑制剂
US10961258B2 (en)	2015-12-21	2021-03-30	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as kinase inhibitors
WO2017123884A1 (en)	2016-01-15	2017-07-20	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as rsv inhibitors
MA44007A (fr)	2016-02-05	2018-12-19	Denali Therapeutics Inc	Inhibiteurs du récepteur interagissant avec protéine kinase 1
US10898469B2 (en)	2016-02-26	2021-01-26	Sumitomo Dainippon Pharma Co., Ltd.	Imidazolylamide derivative
WO2018007973A2 (en)	2016-07-06	2018-01-11	Glaxosmithkline Intellectual Property Development Limited	Process and intermediates for preparing benzoxazepines
WO2018073193A1 (en)	2016-10-17	2018-04-26	F. Hoffmann-La Roche Ag	Bicyclic pyridone lactams and methods of use thereof
TW201822637A (zh)	2016-11-07	2018-07-01	德商拜耳廠股份有限公司	用於控制動物害蟲的經取代磺醯胺類
TW201831464A (zh)	2016-11-18	2018-09-01	英商葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之雜環醯胺
TW201831478A (zh)	2016-12-02	2018-09-01	瑞士商赫孚孟拉羅股份公司	雙環醯胺化合物及其使用方法
ES2912295T3 (es)	2016-12-09	2022-05-25	Denali Therapeutics Inc	Compuestos útiles como inhibidores de RIPK1
US11072607B2 (en) *	2016-12-16	2021-07-27	Genentech, Inc.	Inhibitors of RIP1 kinase and methods of use thereof
EP3560494A4 (en)	2016-12-20	2020-08-05	Sumitomo Dainippon Pharma Co., Ltd.	MEDICINAL PRODUCT TARGETING A CARCINOUS STEM CELL
US10398706B2 (en)	2017-01-06	2019-09-03	Enanta Pharmaceuticals, Inc.	Heteroaryldiazepine derivatives as RSV inhibitors
CN110809472B (zh)	2017-02-16	2023-05-23	英安塔制药有限公司	用于制备苯二氮䓬衍生物的方法
JP2020509009A (ja) *	2017-02-27	2020-03-26	グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＤｅｖｅｌｏｐｍｅｎｔＬｉｍｉｔｅｄ	キナーゼ阻害剤としての複素環式アミド
JOP20190233A1 (ar) *	2017-04-14	2019-10-02	Biogen Ma Inc	نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون
WO2018192416A1 (en) *	2017-04-17	2018-10-25	National Institute Of Biological Sciences, Beijing	Treating Male Senescence
PE20241932A1 (es) *	2017-05-17	2024-09-24	Denali Therapeutics Inc	Inhibidores de quinasa y usos de los mismos
WO2018226801A1 (en)	2017-06-07	2018-12-13	Enanta Pharmaceuticals, Inc.	Aryldiazepine derivatives as rsv inhibitors
WO2019006295A1 (en)	2017-06-30	2019-01-03	Enanta Pharmaceuticals, Inc.	HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
WO2019006291A1 (en)	2017-06-30	2019-01-03	Enanta Pharmaceuticals, Inc.	HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
FI3652178T3 (fi)	2017-07-14	2024-03-19	Hoffmann La Roche	Bisyklisiä ketoniyhdisteitä ja niiden käyttömenetelmiä
EP3687543B1 (en)	2017-09-29	2024-03-20	Enanta Pharmaceuticals, Inc.	Combinations of pharmaceutical agents as rsv inhibitors
KR20200070297A (ko)	2017-10-11	2020-06-17	에프. 호프만-라 로슈 아게	Rip1 키나아제 억제제로서 사용하기 위한 이환형 화합물
PE20211247A1 (es)	2017-10-31	2021-07-13	Hoffmann La Roche	Sulfonas y sulfoxidos biciclicos y metodos de usos de los mismos
WO2019094920A1 (en)	2017-11-13	2019-05-16	Enanta Pharmaceuticals, Inc.	Azepin-2-one derivatives as rsv inhibitors
BR112020009210A2 (pt)	2017-11-13	2020-10-20	Enanta Pharmaceuticals, Inc.	processos para a preparação de compostos derivados de benzodiazepin-2-ona e benzoazepin-2-ona
WO2019123219A1 (en)	2017-12-20	2019-06-27	Glaxosmithkline Intellectual Property Development Limited	Crystalline salt form of (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide
WO2019130230A1 (en)	2017-12-29	2019-07-04	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as kinase inhibitors
US10975094B2 (en)	2018-04-11	2021-04-13	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as RSV inhibitors
WO2019204537A1 (en)	2018-04-20	2019-10-24	Genentech, Inc.	N-[4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol e-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs)
CN110407770B (zh) *	2018-04-27	2022-12-30	复旦大学	3-取代-1,5-苯并氮杂䓬类化合物及其药物用途
PL3788045T3 (pl) *	2018-05-03	2023-10-09	Rigel Pharmaceuticals, Inc.	Związki hamujące rip1 oraz sposoby ich wytwarzania i wykorzystania
JOP20200278A1 (ar) *	2018-05-03	2020-11-03	Rigel Pharmaceuticals Inc	مركبات تثبيط rip1 وطرق لتحضير واستخدامها
WO2019224774A1 (en)	2018-05-23	2019-11-28	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as rip1 kinase inhibitors
WO2019224773A1 (en)	2018-05-23	2019-11-28	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as rip1 kinase inhibitors
CN110642874B (zh) *	2018-06-26	2023-03-28	中国科学院上海有机化学研究所	一类细胞坏死抑制剂及其制备方法和用途
TW202019913A (zh) *	2018-06-26	2020-06-01	中國科學院上海有機化學研究所	細胞壞死抑制劑及其製備方法和用途
LT3594199T (lt) *	2018-07-09	2020-11-10	F.I.S.- Fabbrica Italiana Sintetici S.P.A.	Kristalinis 2-fluor-3-nitroluenas ir jo paruošimo būdas
WO2020044206A1 (en)	2018-08-29	2020-03-05	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as kinase inhibitors for use in the treatment cancer
CN109134448B (zh) *	2018-10-16	2020-11-27	中南大学湘雅医院	杂环化合物及其盐、制备方法、用途和药物
JP7045526B2 (ja)	2018-11-02	2022-03-31	中国科学院上海薬物研究所	Ｒｉｐ１キナーゼを阻害する複素環状アミド及びその使用
CN111138448B (zh) *	2018-11-02	2022-08-02	中国科学院上海药物研究所	抑制rip1激酶的杂环酰胺及其用途
BR112021009854A2 (pt)	2018-11-21	2021-08-17	Enanta Pharmaceuticals, Inc.	heterociclos funcionalizados como agentes antivirais
CN113302193A (zh)	2019-01-11	2021-08-24	豪夫迈·罗氏有限公司	双环吡咯并三唑酮化合物及其使用方法
WO2020151589A1 (zh)	2019-01-25	2020-07-30	北京赛特明强医药科技有限公司	酰胺基桥连杂环类化合物、及其组合物与应用
JP7558189B2 (ja)	2019-03-18	2024-09-30	エナンタファーマシューティカルズインコーポレイテッド	Ｒｓｖ阻害剤としてのベンゾジアゼピン誘導体
WO2020210246A1 (en)	2019-04-09	2020-10-15	Enanta Pharmaceuticals, Inc,	Heterocyclic compounds as rsv inhibitors
WO2020234716A1 (en)	2019-05-17	2020-11-26	Glaxosmithkline Intellectual Property Development Limited	Matrix composition comprising (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide
KR102750159B1 (ko) *	2019-05-31	2025-01-07	메드샤인 디스커버리 아이엔씨.	Rip-1 키나아제 억제제인 바이사이클릭 화합물 및 이의 응용
KR20220044330A (ko) *	2019-08-09	2022-04-07	주식회사 비씨켐	수용체-상호작용 단백질-1 키나아제 저해제로서의 융합된 고리 헤테로아릴 화합물
BR112022002378A2 (pt)	2019-09-06	2022-06-14	Rigel Pharmaceuticals Inc	Compostos inibitórios de rip1 e métodos para preparação e uso dos mesmos
WO2021046515A1 (en)	2019-09-06	2021-03-11	Board Of Regents, The University Of Texas System	Inhibitors of receptor interacting protein kinase i for the treatment of disease
TW202122388A (zh) *	2019-09-06	2021-06-16	美商雷傑製藥公司	Ｒｉｐ１抑制性化合物和用於製備和使用其之方法
JP2022547882A (ja) *	2019-09-06	2022-11-16	インフレイゾームリミテッド	Ｎｌｒｐ３阻害剤
JP2022550099A (ja)	2019-09-27	2022-11-30	ボードオブレジェンツ，ザユニバーシティオブテキサスシステム	疾患の処置のための受容体相互作用プロテインキナーゼｉの阻害剤
US11505558B1 (en)	2019-10-04	2022-11-22	Enanta Pharmaceuticals, Inc.	Antiviral heterocyclic compounds
CN114761016A (zh)	2019-10-04	2022-07-15	英安塔制药有限公司	抗病毒杂环化合物
KR20250095767A (ko) *	2019-11-07	2025-06-26	리겔 파마슈티칼스, 인크.	헤테로시클릭 rip1 억제 화합물
US11690850B2 (en) *	2019-11-26	2023-07-04	Board Of Regents, The University Of Texas System	Inhibitors of receptor interacting protein kinase I for the treatment of disease
UY39032A (es)	2020-01-24	2021-07-30	Enanta Pharm Inc	Compuestos heterocíclicos como agentes antivirales
MX2022010693A (es) *	2020-02-28	2022-09-26	Univ Texas	Compuestos, composiciones y metodos para inhibidores de la proteina quinasa que interactua con el receptor i para el tratamiento de enfermedades.
AR121717A1 (es) *	2020-04-02	2022-06-29	Rigel Pharmaceuticals Inc	Inhibidores de rip1k
TW202214617A (zh)	2020-06-02	2022-04-16	法商賽諾菲公司	作為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途
AR122703A1 (es)	2020-07-01	2022-09-28	Rigel Pharmaceuticals Inc	Inhibidores de rip1k
US11534439B2 (en)	2020-07-07	2022-12-27	Enanta Pharmaceuticals, Inc.	Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
MX2023001979A (es) *	2020-08-18	2023-02-27	Hutchison Medipharma Ltd	Compuestos de pirimidinona y usos de los mismos.
WO2022086840A1 (en)	2020-10-19	2022-04-28	Enanta Pharmaceuticals, Inc.	Heterocyclic compounds as anti-viral agents
CN114716427B (zh) *	2021-01-07	2024-04-26	成都贝诺科成生物科技有限公司	一种作为rip抑制剂的化合物及其制备方法和用途
WO2022171110A1 (en) *	2021-02-10	2022-08-18	Zai Lab (Us) Llc	Fused tricyclic compounds as rip1-kinase inhibitors and uses thereof
WO2022171111A1 (en) *	2021-02-10	2022-08-18	Zai Lab (Us) Llc	Heteroaryl-fused bicyclic compound as rip1-kinase inhibitors and uses thereof
TW202300490A (zh) *	2021-03-11	2023-01-01	美商雷傑製藥公司	雜環rip1激酶抑制劑
CN113045560B (zh) *	2021-03-30	2022-09-06	港科鹏禾生物(苏州)有限公司	一种酰胺类衍生物及其制备方法和应用
IL307250A (en)	2021-04-02	2023-11-01	Hoffmann La Roche	Processes for preparing bicyclic ketone compounds
EP4329766A4 (en) *	2021-04-27	2025-06-11	Merck Sharp & Dohme LLC	RIPK1 INHIBITORS AND METHODS OF USE
CN115246796A (zh) *	2021-04-27	2022-10-28	中国科学院上海有机化学研究所	一种抑制细胞程序性死亡的化合物及其制备方法
TW202321211A (zh)	2021-08-10	2023-06-01	美商艾伯維有限公司	菸鹼醯胺ripk1抑制劑
CN115806557B (zh) *	2021-09-14	2025-02-14	中国科学院上海有机化学研究所	抑制细胞程序性死亡的化合物及其制备方法
EP4402139A1 (en) *	2021-09-17	2024-07-24	Bisichem Co., Ltd.	Fused heterocyclic rings as ripk1 inhibitors
WO2023068881A1 (ko) *	2021-10-22	2023-04-27	주식회사 보로노이바이오	아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
CN113876778B (zh) *	2021-11-05	2023-04-14	中日友好医院(中日友好临床医学研究所)	Kw2449在制备改善类风湿性关节炎药物中的应用
US11897876B2 (en)	2021-11-11	2024-02-13	Genzyme Corporation	Isoxazolidines as RIPK1 inhibitors and use thereof
WO2023119210A1 (ko) *	2021-12-24	2023-06-29	제일약품주식회사	Ripk1 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
AU2023206890A1 (en)	2022-01-12	2024-08-22	Denali Therapeutics Inc.	Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide
CN118647617A (zh)	2022-03-16	2024-09-13	江苏恒瑞医药股份有限公司	稠杂环类化合物、其制备方法及其在医药上的应用
AR129003A1 (es)	2022-04-07	2024-07-03	Enanta Pharm Inc	Compuestos heterocíclicos antivirales
WO2023211997A1 (en)	2022-04-27	2023-11-02	Enanta Pharmaceuticals, Inc.	Antiviral compounds
CN114736197B (zh) *	2022-06-13	2022-09-13	南京医工医药技术有限公司	咪唑啉酮衍生物及其用途
WO2023240379A1 (zh) *	2022-06-13	2023-12-21	南京医工医药技术有限公司	咪唑啉酮衍生物及其用途
CN117447460A (zh) *	2022-07-13	2024-01-26	南京天印健华医药科技有限公司	作为ripk1抑制剂的杂环化合物
WO2024040155A1 (en)	2022-08-19	2024-02-22	Genzyme Corporation	Isoxazolidines as ripk1 inhibitors and use thereof
TW202423921A (zh) *	2022-08-22	2024-06-16	美商安塔製藥公司	稠合的雜雙環抗病毒劑
WO2024158665A1 (en) *	2023-01-23	2024-08-02	Genzyme Corporation	Drug formulations of 4-(3,3-difluoro-2,2-dimethyl-propanoyl)-3,5-dihydro-2h-pyrido [3,4-f] [1,4] oxazepine-9-c arbonitrile
WO2024233544A1 (en)	2023-05-10	2024-11-14	Genzyme Corporation	Isoxazolidines as ripk1 inhibitors and use thereof
WO2024233547A1 (en)	2023-05-10	2024-11-14	Genzyme Corporation	Isoxazolidines as ripk1 inhibitors and use thereof
WO2024233554A1 (en)	2023-05-10	2024-11-14	Genzyme Corporation	Isoxazolidines as ripk1 inhibitors and use thereof
US20250000872A1 (en) *	2023-06-26	2025-01-02	Eli Lilly And Company	Formulations and dosing regimens for rip1 kinase inhibitors for treating autoimmune and inflammatory diseases

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5239065B2 (zh)	1971-11-17	1977-10-03
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
US4692522A (en)	1985-04-01	1987-09-08	Merck & Co., Inc.	Benzofused lactams useful as cholecystokinin antagonists
US5206234A (en)	1990-10-22	1993-04-27	Merck & Co., Inc.	Benzolactam analogs as antagonists of cck
JP3358069B2 (ja)	1991-12-24	2002-12-16	武田薬品工業株式会社	三環性複素環類、その製造法及び剤
ES2193241T3 (es)	1995-06-07	2003-11-01	Merck & Co Inc	Nuevas n-2-oxo2.3.4.5-tetrajodrp-1h-1,5-benzodiazepin-3-il)-3-amidas.
WO1998041510A1 (fr)	1997-03-14	1998-09-24	Shionogi & Co., Ltd.	Nouveaux derives du benzolactame et compositions medicamenteuses les contenant
US6228854B1 (en)	1997-08-11	2001-05-08	Cor Therapeutics, Inc.	Selective factor Xa inhibitors
FR2781483A1 (fr) *	1998-07-21	2000-01-28	Hoechst Marion Roussel Inc	Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant
WO2001002358A2 (en)	1999-07-06	2001-01-11	Vertex Pharmaceuticals Incorporated	Cyclized amide derivatives for treating or preventing neuronal damage
WO2001035964A1 (en)	1999-11-18	2001-05-25	Antexpharma, Inc.	Substituted 1-benzazepines and derivatives thereof
MXPA02009729A (es)	2000-04-03	2003-03-27	Bristol Myers Squibb Pharma Co	Lactamas ciclicas como inhibidores de la produccion de la proteina a-beta.
US6759404B2 (en)	2000-04-03	2004-07-06	Richard E. Olson	Cyclic malonamides as inhibitors of aβ protein production
CA2379445C (en)	2000-06-01	2007-08-21	Bristol-Myers Squibb Pharma Company	Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
DE10054279A1 (de)	2000-11-02	2002-05-16	Apotech Res & Dev Ltd	Verwendung von Liganden von Todesrezeptoren oder RIP zur Auslösung des Caspase-unabhängigen Zelltods und Verbindungen zur Inhibition des Caspase-unabhängigen Zelltods
EP1392317A4 (en)	2001-05-16	2005-10-19	Antexpharma Inc	SUBSTITUTED 1-BENZAZEPINE AND DERIVATIVES THEREOF
US7057046B2 (en) *	2002-05-20	2006-06-06	Bristol-Myers Squibb Company	Lactam glycogen phosphorylase inhibitors and method of use
AU2003229678A1 (en)	2003-04-15	2004-11-04	Dirk Koczan	Method for diagnosing rheumatoid arthritis or osteoarthritis
DE602004016992D1 (de) *	2003-05-02	2008-11-20	Elan Pharm Inc	4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3-carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen
US20080019909A1 (en)	2003-09-17	2008-01-24	Francis Ka-Ming Chan	Modulation of Programmed Necrosis
EP1640012A1 (de)	2004-09-24	2006-03-29	Salama, Zoser B. nat.rer.Dr.	Pharmazeutisches Mittel enthaltend Blutbestandteile 10 kDa und deren Verwendung zur Prophylaxe und Behandlung von Defekten des Immunsystems
US20060067942A1 (en)	2004-09-24	2006-03-30	Salama Zoser B	Pharmaceutical agent comprising amino acids, peptides, proteins and/or fractions and fragments thereof and the use of same in the prophylaxis and treatment of immune system deficiency in humans and animals
FR2894968B1 (fr)	2005-12-20	2008-02-22	Trophos Sa	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
US8324262B2 (en) *	2005-12-20	2012-12-04	The Brigham And Women's Hospital, Inc.	Tricyclic necrostatin compounds
FR2899108B1 (fr)	2006-03-31	2012-02-03	Trophos	Utilisation de derives du cholest-4-en-3-one pour l'obtention d'un medicament cytoprotecteur
US8007790B2 (en)	2006-04-03	2011-08-30	Stowers Institute For Medical Research	Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
FR2907783A1 (fr)	2006-10-30	2008-05-02	Trophos Sa	Nouveaux composes chimiques, leurs procedes de synthese et leur utilisation a titre de medicament, particulierement a titre de medicament cytoprotecteur, neuroprotecteur ou cardioprotecteur
US20080226645A1 (en)	2007-01-10	2008-09-18	Wyeth	Methods and compositions for assessment and treatment of asthma
AU2008219723A1 (en)	2007-02-28	2008-09-04	Merck Sharp & Dohme Corp.	Substituted benzodiazepinones, benzoxazepinones and benzothiazepinones as sodium channel blockers
JP5239065B2 (ja)	2007-04-20	2013-07-17	株式会社大一商会	遊技機
EP3034494A1 (en)	2007-08-15	2016-06-22	President and Fellows of Harvard College	Heterocyclic inhibitors of necroptosis
FR2934596B1 (fr)	2008-07-30	2015-04-10	Trophos	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
US8257921B1 (en)	2008-12-22	2012-09-04	Schering Corporation	NRIP1 regulation of apolipoprotein A1
WO2010075290A1 (en)	2008-12-22	2010-07-01	President And Fellows Of Harvard College	Unsaturated heterocyclic inhibitors of necroptosis
US20120122889A1 (en)	2008-12-23	2012-05-17	President And Fellows Of Harvard College	Small molecule inhibitors of necroptosis
FR2940650B1 (fr)	2008-12-29	2017-01-27	Trophos	Nouveaux derives d'oxime du 3,5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant,et procede de preparation
US7622106B1 (en)	2009-03-06	2009-11-24	Board Of Regents, The University Of Texas System	Necrosis assay
KR101155506B1 (ko)	2009-07-08	2012-06-15	고려대학교 산학협력단	활성산소조절 유전자를 이용한 ｔｎｆ-알파 유도 질병의 치료제 및 예방제의 스크리닝 방법
EP2519260A2 (en)	2009-12-31	2012-11-07	Deutsches Krebsforschungszentrum	Novel modulators of trail signalling
WO2011112588A2 (en)	2010-03-08	2011-09-15	Case Western Reserve University	Compositions and methods for treating inflammatory disorders
AU2011242465B2 (en)	2010-04-23	2017-01-19	Massachusetts Eye And Ear Infirmary	Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells
WO2012009678A1 (en)	2010-07-16	2012-01-19	Agios Pharmaceuticals, Inc.	Therapeutically active compositions and their method of use
US20120022116A1 (en)	2010-07-20	2012-01-26	Huayun Deng	Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
US20140024598A1 (en)	2010-11-01	2014-01-23	Demetrios Vavvas	Methods and compositions for preserving retinal ganglion cells
US9643977B2 (en)	2011-03-11	2017-05-09	President And Fellows Of Harvard College	Necroptosis inhibitors and methods of use therefor
WO2013013826A1 (en)	2011-07-27	2013-01-31	Friedrich-Alexander-Universität Erlangen-Nürnberg	Necroptosis inhibitors for the treatment of inflammatory diseases of the gastrointestinal tract
EP2758780A4 (en)	2011-09-22	2015-09-16	Marv Entpr Llc	METHOD OF TREATING MULTIPLE SCLEROSIS
CN102343102A (zh)	2011-10-19	2012-02-08	柳忠辉	激活素受体相互作用蛋白2基因在制备药物中的应用
US20140357570A1 (en)	2011-10-21	2014-12-04	Massachusetts Eye And Ear Infirmary	Compositions comprising necrosis inhibitors, such as necrostatins, alone or in combination, for promoting axon regeneration and nerve function, thereby treating cns disorders
KR101410332B1 (ko)	2012-02-29	2014-06-24	코아스템(주)	중간엽 기질세포 배양용 항산화 조성물 및 이의 용도
ES2446494B1 (es)	2012-03-28	2015-03-16	Consejo Superior De Investigaciones Científicas (Csic)	Aplicación terapéutica de necrostatina-1 en esteatohepatitis
WO2014022102A1 (en)	2012-08-01	2014-02-06	Amgen Inc.	Methods of using anti-apoptotic compounds to modulate one or more properties of a cell culture
CA2877223C (en)	2012-08-06	2019-08-27	Brainstorm Cell Therapeutics Ltd.	Methods of generating mesenchymal stem cells which secrete neurotrophic factors
US11306360B2 (en)	2012-12-26	2022-04-19	Koninklijke Philips N.V.	Assessment of cellular signaling pathway activity using linear combination(s) of target gene expressions
JPWO2014126127A1 (ja)	2013-02-13	2017-02-02	国立大学法人北海道大学	ネクロプトーシス関連疾患の治療用医薬組成物及びその有効成分のスクリーニング方法
TWI648274B (zh) *	2013-02-15	2019-01-21	英商葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之雜環醯胺類（二）
EP2961849A2 (en)	2013-02-27	2016-01-06	The Broad Institute, Inc.	T cell balance gene expression, compositions of matters and methods of use thereof
WO2014145022A1 (en)	2013-03-15	2014-09-18	President And Fellows Of Harvard College	Hybrid necroptosis inhibitors
US20170266199A1 (en)	2014-08-21	2017-09-21	Glaxosmithkline Intellectual Property Development Limited	Heterocyclic amides as rip1 kinase inhibitors as medicaments
MA44007A (fr)	2016-02-05	2018-12-19	Denali Therapeutics Inc	Inhibiteurs du récepteur interagissant avec protéine kinase 1

2014
- 2014-02-13 TW TW107104621A patent/TWI648274B/zh active
- 2014-02-13 TW TW107104619A patent/TWI648273B/zh active
- 2014-02-13 TW TW103104666A patent/TWI637951B/zh active
- 2014-02-13 TW TW107104622A patent/TWI638815B/zh active
- 2014-02-14 CA CA2900695A patent/CA2900695C/en active Active
- 2014-02-14 BR BR122017002949A patent/BR122017002949A2/pt not_active Application Discontinuation
- 2014-02-14 UA UAA201508769A patent/UA118259C2/uk unknown
- 2014-02-14 TR TR2018/08112T patent/TR201808112T4/tr unknown
- 2014-02-14 DK DK18155836.2T patent/DK3342771T3/da active
- 2014-02-14 SG SG11201505796TA patent/SG11201505796TA/en unknown
- 2014-02-14 SM SM20210083T patent/SMT202100083T1/it unknown
- 2014-02-14 DK DK14705891.1T patent/DK2956452T3/en active
- 2014-02-14 CN CN201480021120.8A patent/CN105121432B/zh active Active
- 2014-02-14 SI SI201430738T patent/SI2956452T1/en unknown
- 2014-02-14 LT LTEP14705891.1T patent/LT2956452T/lt unknown
- 2014-02-14 MX MX2015010572A patent/MX360715B/es active IP Right Grant
- 2014-02-14 SI SI201431772T patent/SI3342771T1/sl unknown
- 2014-02-14 WO PCT/IB2014/059004 patent/WO2014125444A1/en active Application Filing
- 2014-02-14 PL PL14705891T patent/PL2956452T3/pl unknown
- 2014-02-14 RS RS20210156A patent/RS61439B1/sr unknown
- 2014-02-14 CN CN201810758606.XA patent/CN108774214B/zh active Active
- 2014-02-14 ES ES18155836T patent/ES2855135T3/es active Active
- 2014-02-14 KR KR1020157024819A patent/KR102228764B1/ko active Active
- 2014-02-14 CN CN201710029656.XA patent/CN106928203B/zh active Active
- 2014-02-14 BR BR122017002946A patent/BR122017002946A2/pt not_active Application Discontinuation
- 2014-02-14 MY MYPI2015702652A patent/MY178552A/en unknown
- 2014-02-14 EP EP18155836.2A patent/EP3342771B1/en active Active
- 2014-02-14 MY MYPI2020000331A patent/MY195183A/en unknown
- 2014-02-14 MA MA44820A patent/MA44820B1/fr unknown
- 2014-02-14 EA EA201591506A patent/EA028991B1/ru not_active IP Right Cessation
- 2014-02-14 JP JP2015557554A patent/JP6321045B2/ja active Active
- 2014-02-14 LT LTEP18155836.2T patent/LT3342771T/lt unknown
- 2014-02-14 PE PE2015001727A patent/PE20151752A1/es not_active Application Discontinuation
- 2014-02-14 PT PT181558362T patent/PT3342771T/pt unknown
- 2014-02-14 EP EP14705891.1A patent/EP2956452B1/en active Active
- 2014-02-14 ES ES18152185T patent/ES2814556T3/es active Active
- 2014-02-14 MX MX2018008312A patent/MX373867B/es unknown
- 2014-02-14 BR BR112015019627-6A patent/BR112015019627B1/pt active IP Right Grant
- 2014-02-14 HU HUE14705891A patent/HUE037763T2/hu unknown
- 2014-02-14 PT PT147058911T patent/PT2956452T/pt unknown
- 2014-02-14 EP EP19154374.3A patent/EP3508484B1/en active Active
- 2014-02-14 ES ES14705891.1T patent/ES2672530T3/es active Active
- 2014-02-14 US US14/763,183 patent/US9556152B2/en active Active
- 2014-02-14 CR CR20190512A patent/CR20190512A/es unknown
- 2014-02-14 NZ NZ628447A patent/NZ628447A/en unknown
- 2014-02-14 UY UY0001035330A patent/UY35330A/es not_active Application Discontinuation
- 2014-02-14 MX MX2018008311A patent/MX373866B/es unknown
- 2014-02-14 PL PL18155836T patent/PL3342771T3/pl unknown
- 2014-02-14 SM SM20180289T patent/SMT201800289T1/it unknown
- 2014-02-14 CR CR20190511A patent/CR20190511A/es unknown
- 2014-02-14 RS RS20180698A patent/RS57332B1/sr unknown
- 2014-02-14 AU AU2014217453A patent/AU2014217453B2/en active Active
- 2014-02-14 BR BR122017002951A patent/BR122017002951A2/pt not_active Application Discontinuation
- 2014-02-14 EP EP18152185.7A patent/EP3375780B1/en active Active
- 2014-02-14 KR KR1020197004425A patent/KR102267977B1/ko active Active
- 2014-02-14 HR HRP20180900TT patent/HRP20180900T1/hr unknown
- 2014-02-14 HU HUE18155836A patent/HUE053215T2/hu unknown
- 2014-02-14 EA EA201792039A patent/EA031971B1/ru not_active IP Right Cessation
2015
- 2015-07-21 ZA ZA2015/05267A patent/ZA201505267B/en unknown
- 2015-07-28 PH PH12015501675A patent/PH12015501675A1/en unknown
- 2015-07-30 IL IL240280A patent/IL240280B/en active IP Right Grant
- 2015-08-14 DO DO2015000196A patent/DOP2015000196A/es unknown
- 2015-08-14 CL CL2015002279A patent/CL2015002279A1/es unknown
- 2015-08-14 CR CR20150420A patent/CR20150420A/es unknown
2016
- 2016-02-05 HK HK18108760.1A patent/HK1249100A1/zh unknown
- 2016-09-21 US US15/271,581 patent/US9624202B2/en active Active
2017
- 2017-03-15 US US15/459,141 patent/US10292987B2/en active Active
- 2017-12-08 US US15/835,747 patent/US20180098998A1/en not_active Abandoned
- 2017-12-22 IL IL256500A patent/IL256500B/en active IP Right Grant
- 2017-12-22 IL IL256502A patent/IL256502B/en active IP Right Grant
2018
- 2018-02-15 PH PH12018500341A patent/PH12018500341A1/en unknown
- 2018-02-15 PH PH12018500342A patent/PH12018500342A1/en unknown
- 2018-02-15 PH PH12018500343A patent/PH12018500343A1/en unknown
- 2018-03-12 JP JP2018044611A patent/JP6352571B1/ja active Active
- 2018-04-04 DO DO2018000089A patent/DOP2018000089A/es unknown
- 2018-04-04 DO DO2018000088A patent/DOP2018000088A/es unknown
- 2018-06-04 JP JP2018107215A patent/JP2018150372A/ja active Pending
- 2018-06-08 CY CY20181100604T patent/CY1120320T1/el unknown
2019
- 2019-03-12 US US16/299,254 patent/US10933070B2/en active Active
- 2019-05-10 US US16/408,718 patent/US10940154B2/en active Active
2021
- 2021-02-12 CY CY20211100121T patent/CY1123915T1/el unknown
- 2021-02-12 HR HRP20210252TT patent/HRP20210252T1/hr unknown

Also Published As

Publication number	Publication date
EP2956452B1 (en)	2018-03-21
IL256502B (en)	2018-11-29
EP3342771A1 (en)	2018-07-04
RS57332B1 (sr)	2018-08-31
KR102267977B1 (ko)	2021-06-21
PH12015501675A1 (en)	2015-10-19
PT2956452T (pt)	2018-06-01
HUE037763T2 (hu)	2018-09-28
MX373866B (es)	2020-03-26
BR112015019627A2 (pt)	2017-07-18
HUE053215T2 (hu)	2021-06-28
US20190201413A1 (en)	2019-07-04
BR122017002949A2 (pt)	2019-09-10
RS61439B1 (sr)	2021-03-31
EP3508484A1 (en)	2019-07-10
EA028991B1 (ru)	2018-01-31
DOP2018000088A (es)	2018-10-31
MX2015010572A (es)	2015-11-16
JP2018150372A (ja)	2018-09-27
IL240280B (en)	2018-04-30
TWI637951B (zh)	2018-10-11
CA2900695C (en)	2021-10-12
ES2672530T3 (es)	2018-06-14
US10940154B2 (en)	2021-03-09
IL256500A (en)	2018-02-28
PE20151752A1 (es)	2015-11-25
TW201443042A (zh)	2014-11-16
BR122017002951A2 (pt)	2020-01-28
MX373867B (es)	2020-03-26
EA201591506A1 (ru)	2016-01-29
IL256500B (en)	2018-11-29
HK1249100A1 (zh)	2018-10-26
US20190262356A1 (en)	2019-08-29
AU2014217453B2 (en)	2016-04-14
US9556152B2 (en)	2017-01-31
DOP2015000196A (es)	2016-05-15
JP2016512488A (ja)	2016-04-28
DOP2018000089A (es)	2018-06-30
MY178552A (en)	2020-10-16
BR122017002946A2 (pt)	2019-09-10
CR20190511A (es)	2020-01-08
ES2855135T3 (es)	2021-09-23
KR102228764B1 (ko)	2021-03-18
UY35330A (es)	2014-08-29
TW201819369A (zh)	2018-06-01
IL256502A (en)	2018-02-28
LT2956452T (lt)	2018-06-11
KR20150119174A (ko)	2015-10-23
EP2956452A1 (en)	2015-12-23
US10933070B2 (en)	2021-03-02
EA201792039A1 (ru)	2018-01-31
PH12018500342A1 (en)	2018-09-10
LT3342771T (lt)	2021-03-10
JP6352571B1 (ja)	2018-07-04
CN106928203B (zh)	2020-02-07
CY1120320T1 (el)	2019-07-10
US20170183332A1 (en)	2017-06-29
TR201808112T4 (tr)	2018-07-23
CN105121432B (zh)	2018-08-03
ES2814556T3 (es)	2021-03-29
CR20150420A (es)	2015-10-19
NZ628447A (en)	2016-08-26
CY1123915T1 (el)	2022-05-27
UA118259C2 (uk)	2018-12-26
CL2015002279A1 (es)	2016-07-08
US20150353533A1 (en)	2015-12-10
EP3342771B1 (en)	2020-11-25
EP3375780B1 (en)	2020-06-03
EP3508484B1 (en)	2021-04-07
IL240280A0 (en)	2015-09-24
JP6321045B2 (ja)	2018-05-09
EP3375780A1 (en)	2018-09-19
EA031971B1 (ru)	2019-03-29
TWI638815B (zh)	2018-10-21
CN106928203A (zh)	2017-07-07
MY195183A (en)	2023-01-11
DK3342771T3 (da)	2021-02-08
PH12018500341A1 (en)	2018-09-10
TW201819370A (zh)	2018-06-01
CA2900695A1 (en)	2014-08-21
CN108774214A (zh)	2018-11-09
AU2014217453A1 (en)	2015-08-13
BR112015019627B1 (pt)	2022-08-30
ZA201505267B (en)	2017-08-30
HK1253099A1 (zh)	2019-06-06
PT3342771T (pt)	2021-02-11
DK2956452T3 (en)	2018-06-06
US20180098998A1 (en)	2018-04-12
PH12018500343A1 (en)	2018-09-10
PL3342771T3 (pl)	2021-06-14
SI3342771T1 (sl)	2021-04-30
CN108774214B (zh)	2021-03-09
HRP20180900T1 (hr)	2018-07-13
WO2014125444A1 (en)	2014-08-21
MA44820A1 (fr)	2019-09-30
SMT202100083T1 (it)	2021-03-15
HK1213545A1 (zh)	2016-07-08
TWI648273B (zh)	2019-01-21
KR20190018558A (ko)	2019-02-22
CR20190512A (es)	2020-01-08
TW201819368A (zh)	2018-06-01
CN105121432A (zh)	2015-12-02
SI2956452T1 (en)	2018-06-29
TWI648274B (zh)	2019-01-21
JP2018111712A (ja)	2018-07-19
SMT201800289T1 (it)	2018-07-17
US9624202B2 (en)	2017-04-18
MX360715B (es)	2018-11-13
US20170008878A1 (en)	2017-01-12
PL2956452T3 (pl)	2018-08-31
MA44820B1 (fr)	2020-06-30
US10292987B2 (en)	2019-05-21
HRP20210252T1 (hr)	2021-04-02

Publication	Publication Date	Title
IL256500B (en)	2018-11-29	Heterocyclic amides as kinase inhibitors
IL255246A0 (en)	2017-12-31	Heterocyclic amides as kinase inhibitors
IL245672A0 (en)	2016-06-30	Pyrimidopyrimidinones used as wee-1 kinase inhibitors
IL241165B (en)	2019-03-31	Bi-aryl amide compounds as kinase inhibitors
IL243295A0 (en)	2016-02-29	Carbazole carboxamide compounds are useful as kinase inhibitors
GB201307155D0 (en)	2013-05-29	Kinase inhibitors
GB201309603D0 (en)	2013-07-10	Novel compounds and their use as kinase inhibitors
GB201305741D0 (en)	2013-05-15	Novel compounds and their use as kinase inhibitors