SE439921B - Nya platina(iv)diamin-komplex, sett att framstella dessa komplex och ett lekemedel till anvendning for behandling av cancer - Google Patents

Nya platina(iv)diamin-komplex, sett att framstella dessa komplex och ett lekemedel till anvendning for behandling av cancer

Info

Publication number: SE439921B
Authority: SE; Sweden
Prior art keywords: platinum; formula; cis; complex; aminomethyl
Prior art date: 1980-01-03

Application number

SE8100006A

Other languages

English (en)

Swedish (sv)

Other versions

SE8100006L (sv

Inventor

E J Bulten

F Verbeek

Original Assignee

Tno

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-01-03

Filing date

1981-01-02

Publication date

1985-07-08

1981-01-02 Application filed by Tno filed Critical Tno

1981-07-04 Publication of SE8100006L publication Critical patent/SE8100006L/

1985-07-08 Publication of SE439921B publication Critical patent/SE439921B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SE8100006A 1980-01-03 1981-01-02 Nya platina(iv)diamin-komplex, sett att framstella dessa komplex och ett lekemedel till anvendning for behandling av cancer SE439921B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NLAANVRAGE8000032,A NL181434C (nl)	1980-01-03	1980-01-03	Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.

Publications (2)

Publication Number	Publication Date
SE8100006L SE8100006L (sv)	1981-07-04
SE439921B true SE439921B (sv)	1985-07-08

Family

ID=19834620

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8100006A SE439921B (sv)	1980-01-03	1981-01-02	Nya platina(iv)diamin-komplex, sett att framstella dessa komplex och ett lekemedel till anvendning for behandling av cancer

Country Status (31)

Country	Link
US (2)	US4431666A (fi)
JP (1)	JPS56100796A (fi)
AR (1)	AR227903A1 (fi)
AT (1)	AT377242B (fi)
AU (1)	AU542600B2 (fi)
BE (1)	BE886929A (fi)
CA (1)	CA1154030A (fi)
CH (1)	CH650003A5 (fi)
CS (1)	CS239911B2 (fi)
DD (1)	DD156909A5 (fi)
DE (1)	DE3100017A1 (fi)
DK (1)	DK153468C (fi)
ES (2)	ES8205231A1 (fi)
FI (1)	FI72321C (fi)
FR (1)	FR2473046A1 (fi)
GB (1)	GB2066819B (fi)
GR (1)	GR72849B (fi)
HU (1)	HU184922B (fi)
IE (1)	IE50653B1 (fi)
IL (1)	IL61708A (fi)
IT (1)	IT1193395B (fi)
LU (1)	LU83046A1 (fi)
NL (1)	NL181434C (fi)
NO (1)	NO810004L (fi)
NZ (1)	NZ195926A (fi)
PH (1)	PH21998A (fi)
PT (1)	PT72298B (fi)
SE (1)	SE439921B (fi)
SU (1)	SU1083911A3 (fi)
YU (1)	YU41754B (fi)
ZA (1)	ZA8114B (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8101026A (nl) *	1981-03-03	1982-10-01	Tno	Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
US4786725A (en) *	1982-06-28	1988-11-22	Engelhard Corporation	Solubilized platinum (II) complexes
US4598091A (en) *	1983-02-18	1986-07-01	Degussa Aktiengesellschaft	(1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds
JPS6087295A (ja) *	1983-10-19	1985-05-16	Nippon Kayaku Co Ltd	新規白金錯体
US4599352A (en) *	1984-03-01	1986-07-08	The United States Of America As Represented By The Department Of Health And Human Services	Antineoplastic platinum (IV) complexes and compositions
US4550187A (en) *	1984-04-12	1985-10-29	The Research Foundation Of State University Of New York	Synthesis of platinum (IV) antineoplastic agents
HU193809B (en) *	1984-09-12	1987-12-28	Chugai Pharmaceutical Co Ltd	Process for producing new platinum complexes
US4737589A (en) *	1985-08-27	1988-04-12	Nippon Kayaku Kabushiki Kaisha	Platinum Complexes
US4658047A (en) *	1985-09-27	1987-04-14	The United States Of America As Represented By The Department Of Health And Human Services	Method of preparing 1,2-diaminocyclohexane tetrachloro platinum (IV) isomers
US5041581A (en) *	1985-10-18	1991-08-20	The University Of Texas System Board Of Regents	Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5117022A (en) *	1985-10-18	1992-05-26	The Board Of Regents, The University Of Texas System	Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5384127A (en) *	1985-10-18	1995-01-24	Board Of Regents, The University Of Texas System	Stable liposomal formulations of lipophilic platinum compounds
US4760157A (en) *	1986-01-31	1988-07-26	American Cyanamid Company	(2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
JPS63203692A (ja) *	1987-02-19	1988-08-23	Nippon Kayaku Co Ltd	新規白金錯体
ES2054778T3 (es) *	1988-01-09	1994-08-16	Asta Medica Ag	Complejos de 1,2-bis (aminometil) ciclobutano-platino.
NL8802150A (nl) *	1988-08-31	1990-03-16	Tno	Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
NL8802149A (nl) *	1988-08-31	1990-03-16	Tno	Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
US5041578A (en) *	1988-11-22	1991-08-20	Board Of Regents, The University Of Texas System	Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5393909A (en) *	1988-11-22	1995-02-28	Board Of Regents, The University Of Texas System	Diamine platinum complexes as antitumor agents
US5434256A (en) *	1988-11-22	1995-07-18	Board Of Regents, The University Of Texas System	Diamine platinum complexes as antitumor agents
US4994591A (en) *	1989-06-02	1991-02-19	The Research Foundation Of State University Of Ny	Platinum complexes derived from b-silyamines
US5196555A (en) *	1989-10-17	1993-03-23	Bristol-Myers Squibb Company	Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
FI905018A0 (fi) *	1989-10-17	1990-10-12	Bristol Myers Squibb Co	I vatten och loesningsmedel loesliga axiala hydroxi-och mono- och dikarboxylsyraderivat med stor tumoeraktivitet.
US5130450A (en) *	1990-04-25	1992-07-14	Nippon Kayaku Kabushiki Kaisha	Platinum complexes
GB9211291D0 (en) *	1992-05-28	1992-07-15	British Tech Group	Antifungal compounds
DE4415263C1 (de) *	1994-04-15	1995-11-30	Asta Medica Ag	Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung
US5843475A (en)	1996-12-06	1998-12-01	Board Of Regents, The University Of Texas System	Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
US6264891B1 (en) *	1998-12-22	2001-07-24	Eos Biotechnology, Inc.	Apparatus and method for concurrent chemical synthesis
EP1229934B1 (en)	1999-10-01	2014-03-05	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN105198933B (zh) *	2014-06-20	2018-08-14	贵州益佰制药股份有限公司	一种洛铂晶体、制备方法及药物应用
RU2695357C1 (ru)	2015-06-24	2019-07-23	Ниппон Каяку Кабусики Каися	Новый комплекс платины (iv)
CA2998559A1 (en)	2015-09-14	2017-03-23	Nippon Kayaku Kabushiki Kaisha	Polymer conjugate of hexa-coordinated platinum complex
CN105713046B (zh) *	2016-02-01	2018-10-26	复旦大学	一种铂类抗肿瘤前体药物，其纳米水凝胶药物及其制备方法
CN106946946A (zh) *	2017-03-29	2017-07-14	昆明贵研药业有限公司	一种铂类抗肿瘤药物米铂氧化物的制备方法
EP3986466A1 (en) *	2019-06-18	2022-04-27	Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V.	Site-specific, kinetically inert conjugation of labels and/or carriers to target molecules such as his-tagged proteins via metal complex reagents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH605550A5 (fi) *	1972-06-08	1978-09-29	Research Corp
US4053587A (en) *	1973-04-13	1977-10-11	Research Corporation	Method of treating viral infections
GB1578323A (en) *	1976-02-26	1980-11-05	Rustenburg Platinum Mines Ltd	Compositions containing platinum
SE7810798L (sv) *	1977-10-19	1979-04-20	Johnson Matthey Co Ltd	Kompositioner, innehallande platina
SE7903359L (sv) *	1978-04-20	1979-10-21	Johnson Matthey Co Ltd	Kompositioner innehallande platina
GB2019405A (en) *	1978-04-20	1979-10-31	Johnson Matthey & Co Ltd Pt	Pt (II) and (IV) Amino-Acid Complexes
SE7903361L (sv) *	1978-04-20	1979-10-21	Johnson Matthey Co Ltd	Kompositioner innehallande platina
JPS6034958B2 (ja) *	1978-09-02	1985-08-12	喜徳喜谷	新規白金錯体

1980
- 1980-01-03 NL NLAANVRAGE8000032,A patent/NL181434C/xx not_active IP Right Cessation
- 1980-12-03 IE IE2744/80A patent/IE50653B1/en not_active IP Right Cessation
- 1980-12-04 CH CH8972/80A patent/CH650003A5/de not_active IP Right Cessation
- 1980-12-15 IL IL61708A patent/IL61708A/xx unknown
- 1980-12-19 AR AR283721A patent/AR227903A1/es active
- 1980-12-23 SU SU803217401A patent/SU1083911A3/ru active
- 1980-12-23 NZ NZ195926A patent/NZ195926A/xx unknown
- 1980-12-30 GR GR63769A patent/GR72849B/el unknown
- 1980-12-30 ES ES498240A patent/ES8205231A1/es not_active Expired
- 1980-12-30 JP JP18945180A patent/JPS56100796A/ja active Granted
- 1980-12-30 HU HU803161A patent/HU184922B/hu not_active IP Right Cessation
- 1980-12-31 CS CS809611A patent/CS239911B2/cs unknown
- 1980-12-31 IT IT27029/80A patent/IT1193395B/it active
- 1980-12-31 YU YU3363/80A patent/YU41754B/xx unknown
- 1980-12-31 BE BE0/203372A patent/BE886929A/nl not_active IP Right Cessation
- 1980-12-31 CA CA000367793A patent/CA1154030A/en not_active Expired
- 1980-12-31 PT PT72298A patent/PT72298B/pt not_active IP Right Cessation
1981
- 1981-01-02 DK DK001681A patent/DK153468C/da not_active IP Right Cessation
- 1981-01-02 GB GB8100027A patent/GB2066819B/en not_active Expired
- 1981-01-02 SE SE8100006A patent/SE439921B/sv not_active IP Right Cessation
- 1981-01-02 DE DE19813100017 patent/DE3100017A1/de not_active Ceased
- 1981-01-02 FI FI810002A patent/FI72321C/fi not_active IP Right Cessation
- 1981-01-02 AU AU65949/81A patent/AU542600B2/en not_active Ceased
- 1981-01-02 ZA ZA00810014A patent/ZA8114B/xx unknown
- 1981-01-02 LU LU83046A patent/LU83046A1/de unknown
- 1981-01-02 NO NO810004A patent/NO810004L/no unknown
- 1981-01-02 PH PH25046A patent/PH21998A/en unknown
- 1981-01-02 AT AT0000381A patent/AT377242B/de not_active IP Right Cessation
- 1981-01-02 DD DD81226806A patent/DD156909A5/de not_active IP Right Cessation
- 1981-01-05 FR FR8100058A patent/FR2473046A1/fr active Granted
- 1981-02-06 US US06/232,298 patent/US4431666A/en not_active Expired - Fee Related
- 1981-11-26 ES ES507474A patent/ES507474A0/es active Granted
1983
- 1983-01-18 US US06/458,979 patent/US4482569A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK153468B (da)	1988-07-18
IE50653B1 (en)	1986-06-11
US4482569A (en)	1984-11-13
SE8100006L (sv)	1981-07-04
CA1154030A (en)	1983-09-20
ES498240A0 (es)	1982-06-01
IL61708A (en)	1984-05-31
JPH0428716B2 (fi)	1992-05-15
YU41754B (en)	1987-12-31
ES8205231A1 (es)	1982-06-01
DK1681A (da)	1981-07-04
GB2066819B (en)	1984-01-18
FR2473046B1 (fi)	1985-03-01
GB2066819A (en)	1981-07-15
PT72298A (en)	1981-01-01
NL181434C (nl)	1987-08-17
ZA8114B (en)	1982-01-27
NZ195926A (en)	1983-04-12
PT72298B (en)	1981-11-10
YU336380A (en)	1983-10-31
JPS56100796A (en)	1981-08-12
AT377242B (de)	1985-02-25
CS239911B2 (en)	1986-01-16
HU184922B (en)	1984-11-28
IL61708A0 (en)	1981-01-30
DK153468C (da)	1988-12-12
GR72849B (fi)	1983-12-07
IE802744L (en)	1981-07-03
NL8000032A (nl)	1981-08-03
NO810004L (no)	1981-07-06
FI72321B (fi)	1987-01-30
SU1083911A3 (ru)	1984-03-30
NL181434B (nl)	1987-03-16
ES8207119A1 (es)	1982-09-01
PH21998A (en)	1988-05-02
BE886929A (nl)	1981-06-30
AU542600B2 (en)	1985-02-28
ATA381A (de)	1984-07-15
US4431666A (en)	1984-02-14
FI72321C (fi)	1987-05-11
DD156909A5 (de)	1982-09-29
CH650003A5 (de)	1985-06-28
LU83046A1 (de)	1981-03-27
IT8027029A0 (it)	1980-12-31
FI810002L (fi)	1981-07-04
FR2473046A1 (fr)	1981-07-10
IT1193395B (it)	1988-06-15
DE3100017A1 (de)	1981-11-19
AR227903A1 (es)	1982-12-30
AU6594981A (en)	1981-07-09
ES507474A0 (es)	1982-09-01

Publication	Publication Date	Title
SE439921B (sv)	1985-07-08	Nya platina(iv)diamin-komplex, sett att framstella dessa komplex och ett lekemedel till anvendning for behandling av cancer
Connors et al.	1972	New platinum complexes with anti-tumour activity
US4140707A (en)	1979-02-20	Malonato platinum anti-tumor compounds
SU1160937A3 (ru)	1985-06-07	Способ получени платино-диаминовых комплексов
JPH0244837B2 (fi)	1990-10-05
FI71565B (fi)	1986-10-10	Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara platinakomplex av 1-amino-2-aminometyl- 3,3,5-trimetylcyklopentan
Meischen et al.	1976	Antileukemic properties of organoplatinum complexes
HU224716B1 (en)	2006-01-30	Platinum complex, its preparation and therapeutic application
US4234500A (en)	1980-11-18	Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
US4657927A (en)	1987-04-14	Malonato platinum compounds
FI76351B (fi)	1988-06-30	Foerfarande foer framstaellning av 2,2-substituerade 1,3-alkandiaminplatina(ii)komplexer med antitumoeraktivitet.
KR910009823B1 (ko)	1991-11-30	백금착물(白金錯物)
US4291027A (en)	1981-09-22	Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes
NO891067L (no)	1989-09-15	Platinakoordinasjonsforbindelse og fremgangsmaate til deres fremstilling.
GB2055377A (en)	1981-03-04	Cis-platinum(II) amine ascorbate complexes
NL8802149A (nl)	1990-03-16	Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
JPS61249993A (ja)	1986-11-07	新規有機白金錯体及びその製法
EP0109677A2 (en)	1984-05-30	Diplatinum complex, method for preparing and an anti-cancer agent containing same
EP0232784B1 (en)	1992-12-02	(gem-heterocyclodimethanamine-n,n')platinum complexes
Sampedro et al.	1995	Preclinical studies with new pyrrolidine platinum (II) compounds
Haghighi	1979	Preparation and Reactivity of Platinum Coordination Complexes
Mijajlović et al.	2016	Cytotoxicity of platinum (IV) and palladium (II) complexes with meso-1, 2-diphenyl-ethylenediamine-N, N'-di-3-propanoic acid. Crystal structure of [Pd (1, 2-dpheddp)] complex
JPS6176497A (ja)	1986-04-18	白金錯体
GB2303627A (en)	1997-02-26	Anti-tumour platinum complex
Arsenijević et al.	2016	CYTOTOXICITY OF PLATINUM (IV) AND PALLADIUM (II) COMPLEXES WITH meso-1, 2-DIPHENYL-ETHYLENEDIAMINE-N, N'-DI-3-PROPANOIC ACID.

Legal Events

Date	Code	Title	Description
1995-01-31	NUG	Patent has lapsed	Ref document number: 8100006-9 Effective date: 19940810 Format of ref document f/p: F

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