RS53270B2 - Monoklonalna antitela protiv amiloidnog beta proteina i njihova upotreba - Google Patents

Monoklonalna antitela protiv amiloidnog beta proteina i njihova upotreba

Info

Publication number: RS53270B2
Authority: RS; Serbia
Prior art keywords: monoclonal antibodies; antibodies against; amyloid beta; beta protein; against amyloid
Prior art date: 2005-11-30

Application number

RS20140180A

Other languages

English (en)

Inventor

Boris Labkovsky

Stefan Barghorn

Heinz Hillen

Ulrich Ebert

Andreas R Striebinger

Patrick Keller

Original Assignee

Abbvie Deutschland

Abbvie Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-30

Filing date

2006-11-30

Publication date

2018-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38069205&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS53270(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-11-30 Application filed by Abbvie Deutschland, Abbvie Inc filed Critical Abbvie Deutschland

2014-08-29 Publication of RS53270B publication Critical patent/RS53270B/sr

2018-05-31 Publication of RS53270B2 publication Critical patent/RS53270B2/sr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Physics & Mathematics (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Mycology (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Peptides Or Proteins (AREA)

RS20140180A 2005-11-30 2006-11-30 Monoklonalna antitela protiv amiloidnog beta proteina i njihova upotreba RS53270B2 (sr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US74086605P	2005-11-30	2005-11-30
US77895006P	2006-03-03	2006-03-03
EP06838873.5A EP1976877B2 (en)	2005-11-30	2006-11-30	Monoclonal antibodies against amyloid beta protein and uses thereof
PCT/US2006/046148 WO2007064972A2 (en)	2005-11-30	2006-11-30	Monoclonal antibodies against amyloid beta protein and uses thereof

Publications (2)

Publication Number	Publication Date
RS53270B RS53270B (sr)	2014-08-29
RS53270B2 true RS53270B2 (sr)	2018-05-31

Family

ID=38069205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RS20140180A RS53270B2 (sr)	2005-11-30	2006-11-30	Monoklonalna antitela protiv amiloidnog beta proteina i njihova upotreba

Country Status (21)

Country	Link
US (6)	US8497072B2 (sr)
EP (1)	EP1976877B2 (sr)
JP (9)	JP5486808B2 (sr)
KR (6)	KR20140087058A (sr)
CN (2)	CN101506236B (sr)
AU (1)	AU2006320392B2 (sr)
BR (1)	BRPI0619357B8 (sr)
CA (1)	CA2631195C (sr)
DK (1)	DK1976877T4 (sr)
ES (1)	ES2453941T5 (sr)
HK (1)	HK1119186A1 (sr)
HR (1)	HRP20140240T4 (sr)
IL (8)	IL297746A (sr)
MX (1)	MX2022005782A (sr)
PL (1)	PL1976877T5 (sr)
PT (1)	PT1976877E (sr)
RS (1)	RS53270B2 (sr)
RU (1)	RU2432362C2 (sr)
SG (2)	SG10201706600VA (sr)
WO (1)	WO2007064972A2 (sr)
ZA (1)	ZA200804686B (sr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10303974A1 (de)	2003-01-31	2004-08-05	Abbott Gmbh & Co. Kg	Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
BRPI0619249A2 (pt)	2005-11-30	2011-09-20	Abbott Lab	anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
ES2453941T5 (es)	2005-11-30	2017-05-31	Abbvie Inc.	Anticuerpos monoclonales contra la proteína beta amiloide y usos de los mismos
KR101591206B1 (ko) *	2005-12-12	2016-02-04	에이씨 이뮨 에스.에이.	치료적 특성을 갖는 베타 1-42 특이적인 단일클론성 항체
EP2046833B9 (en)	2006-07-14	2014-02-19	AC Immune S.A.	Humanized antibody against amyloid beta
AU2016204956B2 (en) *	2006-07-14	2018-07-26	Ac Immune S.A.	Humanized antibody against amyloid beta
AU2013202799C1 (en) *	2006-07-14	2019-01-03	Ac Immune S.A.	Humanized antibody against amyloid beta
CN101516911B (zh) *	2006-07-14	2016-11-16	Ac免疫有限公司	针对淀粉状蛋白β的人源化抗体
PL2074145T3 (pl) *	2006-10-02	2017-11-30	Ac Immune S.A.	Humanizowane przeciwciało przeciw amyloidowi beta
US8455626B2 (en)	2006-11-30	2013-06-04	Abbott Laboratories	Aβ conformer selective anti-aβ globulomer monoclonal antibodies
IL199534A (en)	2007-01-05	2013-01-31	Univ Zuerich	An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses.
ES2641897T3 (es) *	2007-01-05	2017-11-14	University Of Zurich	Procedimiento para proporcionar moléculas de unión y diana específicas de una enfermedad
EP2104682B1 (en)	2007-01-11	2016-09-21	Michael Bacher	Diagnosis and treatment of alzheimer's and other neurodementing diseases
WO2008104386A2 (en)	2007-02-27	2008-09-04	Abbott Gmbh & Co. Kg	Method for the treatment of amyloidoses
US8323654B2 (en)	2007-05-14	2012-12-04	Medtronic, Inc.	Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
US7931899B2 (en)	2007-05-14	2011-04-26	Medtronic, Inc	Humanized anti-amyloid beta antibodies
US20090232801A1 (en) *	2007-05-30	2009-09-17	Abbot Laboratories	Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
JP2010528583A (ja) *	2007-06-11	2010-08-26	エーシーイミューンソシエテアノニム	アミロイドβに対するヒト化抗体
US8048420B2 (en)	2007-06-12	2011-11-01	Ac Immune S.A.	Monoclonal antibody
CL2008001741A1 (es) *	2007-06-12	2008-11-21	Genentech Inc	Anticuerpo quimerico o humanizado o fragmento de los mismos que se unen especificamente a por lo menos un epitope en la proteina beta-amiloide; molecula de acido nucleico que lo codifica; composicion que lo comprende; y su uso para tratar enfermedades asociados con la formacion de placas amiloides.
TWI453217B (zh)	2007-06-12	2014-09-21	Ac Immune Sa	抗β類澱粉蛋白單株抗體
US8613923B2 (en)	2007-06-12	2013-12-24	Ac Immune S.A.	Monoclonal antibody
US9403902B2 (en)	2007-10-05	2016-08-02	Ac Immune S.A.	Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
PL2207568T3 (pl)	2007-11-16	2018-01-31	Univ Rockefeller	Przeciwciała specyficzne względem postaci protofibrylarnej białka beta-amyloidu
EP2586797A3 (en) *	2007-11-27	2013-07-24	Medtronic, Inc.	Humanized anti-amyloid beta antibodies
EP2376120A2 (en)	2008-11-25	2011-10-19	Biogen Idec MA Inc.	Use of dr6 and p75 antagonists to promote survival of cells of the nervous system
WO2010069603A1 (en)	2008-12-19	2010-06-24	Neurimmune Therapeutics Ag	Human anti-alpha-synuclein autoantibodies
TW201121570A (en)	2009-11-12	2011-07-01	Genentech Inc	A method of promoting dendritic spine density
EP2558494B1 (en)	2010-04-15	2018-05-23	AbbVie Inc.	Amyloid-beta binding proteins
WO2011149461A1 (en) *	2010-05-27	2011-12-01	Medtronic, Inc.	Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
NZ606357A (en)	2010-07-30	2015-05-29	Genentech Inc	Safe and functional humanized anti beta-amyloid antibody
EP3533803B1 (en)	2010-08-14	2021-10-27	AbbVie Inc.	Anti-amyloid-beta antibodies
US20140011691A1 (en)	2010-10-26	2014-01-09	Arizona Board of Regents, A Body Corporate of the State of Arizona, Acting for and on Behalf of Az.	Morphology and protein specific reagents as diagnostics for neurodegenerative diseases
WO2012142301A2 (en)	2011-04-12	2012-10-18	Quanterix Corporation	Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
EP2723379B1 (en)	2011-06-23	2018-09-12	Biogen International Neuroscience GmbH	Anti-alpha synuclein binding molecules
KR101190573B1 (ko)	2011-10-07	2012-10-18	대한민국	혈액 내 아밀로이드-베타 항체에 특이적으로 결합하는 신규 Ａβ２２（ｐＥ）－４２ 펩티드를 유효성분으로 포함하는 치매 진단용 키트
WO2013094614A1 (ja) *	2011-12-22	2013-06-27	Ｔａｏヘルスライフファーマ株式会社	合成アミロスフェロイドの製造方法
DE102011057021A1 (de) *	2011-12-23	2013-06-27	Forschungszentrum Jülich GmbH	Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten
US9765151B2 (en) *	2013-03-11	2017-09-19	Cured Inc.	Method for producing monoclonal IgA antibody
EP3683232A1 (en)	2013-09-13	2020-07-22	F. Hoffmann-La Roche AG	Methods and compositions comprising purified recombinant polypeptides
MX2016002799A (es)	2013-09-13	2016-05-26	Genentech Inc	Composiciones y metodos para detectar y cuantificar la proteina en la celula hospedera en las lineas de celulas y productos de polipeptidos recombinantes.
WO2015105973A1 (en)	2014-01-08	2015-07-16	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	ANTIBODY TARGETING CELL SURFACE DEPOSITED COMPLEMENT PROTEIN C3d AND USE THEREOF
EP2899543A1 (en) *	2014-01-28	2015-07-29	Predemtec GmbH	Biomarker and methods for early diagnosis of Alzheimer's disease
WO2015115849A1 (ko) *	2014-01-29	2015-08-06	주식회사 엘지생명과학	배양배지의 최적화를 통한 재조합 단백질의 갈락토오스화를 조절하는 방법
US20150246963A1 (en) *	2014-02-08	2015-09-03	Genentech, Inc.	Methods of treating alzheimer's disease
WO2015165961A1 (en)	2014-04-29	2015-11-05	Affiris Ag	Treatment and prevention of alzheimer's disease (ad)
AU2015292678B2 (en)	2014-07-22	2020-10-22	Cb Therapeutics, Inc.	Anti-PD-1 antibodies
JP6909153B2 (ja)	2014-08-05	2021-07-28	アポロミクスインコーポレイテッド	抗ｐｄ−ｌ１抗体
MA41115A (fr)	2014-12-02	2017-10-10	Biogen Int Neuroscience Gmbh	Procédé de traitement de la maladie d'alzheimer
CA3070446A1 (en)	2017-07-25	2019-01-31	Immutics, Inc.	Treating cancer by blocking the interaction of tim-3 and its ligand
ES2945165T3 (es)	2017-08-22	2023-06-28	Biogen Ma Inc	Composiciones farmacéuticas que contienen anticuerpos anti-beta-amiloides
US20190185091A1 (en) *	2017-12-15	2019-06-20	Dejan Mitrovic	Multifunctional motorcycle passenger seat system
RU2703494C1 (ru) *	2018-11-12	2019-10-18	Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства	Моноклональное антитело 6g1 к производным морфина
CN111518205B (zh) *	2019-02-01	2022-03-29	长春金赛药业有限责任公司	人源化抗Aβ单克隆抗体及其应用
JP7373286B2 (ja) *	2019-02-20	2023-11-02	シスメックス株式会社	被検物質の情報の取得方法及び被検物質の捕捉方法
WO2022169211A1 (ko) *	2021-02-03	2022-08-11	한양대학교 산학협력단	베타아밀로이드를 포함하는 만성통증 질환 예방 또는 치료용 조성물

Family Cites Families (743)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2500076C3 (de)	1975-01-02	1982-11-18	SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld	Verfahren zur Gewinnung von intravenös-verträglichen Gammaglobulinen
US4399216A (en)	1980-02-25	1983-08-16	The Trustees Of Columbia University	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en)	1980-02-25	1987-01-06	The Trustees Of Columbia University In The City Of New York	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en)	1980-02-25	1993-01-12	The Trustees Of Columbia University In The City Of New York	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
NO812612L (no)	1980-08-06	1982-02-08	Ferring Pharma Ltd	Enzym-inhibitorer.
WO1982001011A1 (en)	1980-09-24	1982-04-01	Corp Cetus	Diagnostic method and probe
US4582788A (en)	1982-01-22	1986-04-15	Cetus Corporation	HLA typing method and cDNA probes used therein
ATE53862T1 (de)	1982-01-22	1990-06-15	Cetus Corp	Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
US4510245A (en)	1982-11-18	1985-04-09	Chiron Corporation	Adenovirus promoter system
GB8308235D0 (en)	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
US4526039A (en)	1983-06-23	1985-07-02	The United States Of America As Represented By The Secretary Of Transportation	Removable strain gauge fixture and method for measuring accumulated strain in a material
US4683194A (en)	1984-05-29	1987-07-28	Cetus Corporation	Method for detection of polymorphic restriction sites and nucleic acid sequences
US5807715A (en)	1984-08-27	1998-09-15	The Board Of Trustees Of The Leland Stanford Junior University	Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5128326A (en)	1984-12-06	1992-07-07	Biomatrix, Inc.	Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US5168062A (en)	1985-01-30	1992-12-01	University Of Iowa Research Foundation	Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4683202A (en)	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
US6492107B1 (en)	1986-11-20	2002-12-10	Stuart Kauffman	Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
DE3590766C2 (sr)	1985-03-30	1991-01-10	Marc Genf/Geneve Ch Ballivet
US4666829A (en)	1985-05-15	1987-05-19	University Of California	Polypeptide marker for Alzheimer's disease and its use for diagnosis
US4980286A (en)	1985-07-05	1990-12-25	Whitehead Institute For Biomedical Research	In vivo introduction and expression of foreign genetic material in epithelial cells
US5618920A (en)	1985-11-01	1997-04-08	Xoma Corporation	Modular assembly of antibody genes, antibodies prepared thereby and use
US4968615A (en)	1985-12-18	1990-11-06	Ciba-Geigy Corporation	Deoxyribonucleic acid segment from a virus
DE3600905A1 (de)	1986-01-15	1987-07-16	Ant Nachrichtentech	Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
CA1284931C (en)	1986-03-13	1991-06-18	Henry A. Erlich	Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
GB8607679D0 (en)	1986-03-27	1986-04-30	Winter G P	Recombinant dna product
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
US5107065A (en)	1986-03-28	1992-04-21	Calgene, Inc.	Anti-sense regulation of gene expression in plant cells
CA1338457C (en)	1986-08-22	1996-07-16	Henry A. Erlich	Purified thermostable enzyme
US5525339A (en)	1986-08-27	1996-06-11	Dms Pharmaceutical Inc.	Isolated components of dense microspheres derived from mammalian brain tissue and antibodies thereto
US5231170A (en)	1986-08-27	1993-07-27	Paul Averback	Antibodies to dense microspheres
US4946778A (en)	1987-09-21	1990-08-07	Genex Corporation	Single polypeptide chain binding molecules
US5811310A (en)	1986-09-30	1998-09-22	Albert Einstein College Of Medicine Of Yeshiva Univ.	The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
JPS63240797A (ja)	1986-10-14	1988-10-06	Shin Etsu Chem Co Ltd	モノクローナル抗体、その製法およびそれを含有する診断薬
EP0332640A1 (en)	1986-11-17	1989-09-20	California Biotechnology, Inc.	Recombinant alzheimer's amyloid protein
DE3702789A1 (de)	1987-01-30	1988-08-18	Bayer Ag	Vorlaeuferprotein des apc-polypeptids, dafuer codierende dna und diagnostische verwendung der dna und des proteins
EP0307434B2 (en)	1987-03-18	1998-07-29	Scotgen Biopharmaceuticals, Inc.	Altered antibodies
JPS63245689A (ja)	1987-03-31	1988-10-12	Suntory Ltd	ヒトアミロイド関連蛋白モノクロ−ナル抗体
US5258498A (en)	1987-05-21	1993-11-02	Creative Biomolecules, Inc.	Polypeptide linkers for production of biosynthetic proteins
US4880078A (en)	1987-06-29	1989-11-14	Honda Giken Kogyo Kabushiki Kaisha	Exhaust muffler
CA1340802C (en)	1987-08-15	1999-10-26	Yasuyuki Takahashi	Senile amyloid precursor protein and an antibody specific for the same
US5004697A (en)	1987-08-17	1991-04-02	Univ. Of Ca	Cationized antibodies for delivery through the blood-brain barrier
CA1339014C (en)	1987-10-08	1997-03-25	Ronald E. Majocha	Antibodies to a4 amyloid peptide
US5231000A (en)	1987-10-08	1993-07-27	The Mclean Hospital	Antibodies to A4 amyloid peptide
JP2562623B2 (ja)	1987-10-28	1996-12-11	国際電信電話株式会社	ベースバンド合成法による偏波ダイバーシティ光受信方式
WO1989006689A1 (en)	1988-01-13	1989-07-27	The Mclean Hospital Corporation	Genetic constructs containing the alzheimer brain amyloid gene
AU3204689A (en)	1988-02-10	1989-09-06	Children's Medical Center Corporation	Amyloid protein precursors, genetic probes, antibodies, and methods of use
US5134062A (en)	1988-03-22	1992-07-28	Cornell Research Foundation, Inc.	Diagnosis of neuronal disorders and screening potential therapeutic agents therefor
US5015570A (en)	1988-05-13	1991-05-14	Molecular Therapeutics, Inc.	Molecular diagnosis of Alzheimer Disease
US6287793B1 (en)	1988-08-19	2001-09-11	Elan Pharmaceuticals, Inc.	Diagnostic methods for alzheimer's disease
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
EP1997891A1 (en)	1988-09-02	2008-12-03	Dyax Corporation	Generation and selection of recombinant varied binding proteins
ES2052027T5 (es)	1988-11-11	2005-04-16	Medical Research Council	Clonacion de secuencias de dominio variable de inmunoglobulina.
IL162181A (en) †	1988-12-28	2006-04-10	Pdl Biopharma Inc	A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US20030229208A1 (en)	1988-12-28	2003-12-11	Protein Design Labs, Inc.	Humanized immunoglobulins
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
US5231020A (en)	1989-03-30	1993-07-27	Dna Plant Technology Corporation	Genetic engineering of novel plant phenotypes
US5262332A (en)	1989-04-05	1993-11-16	Brigham And Women's Hospital	Diagnostic method for Alzheimer's disease: examination of non-neural tissue
AU5525090A (en)	1989-04-14	1990-11-16	Research Foundation For Mental Hygiene, Inc.	Monoclonal antibody to amyloid peptide
CA2016842A1 (en)	1989-05-16	1990-11-16	Richard A. Lerner	Method for tapping the immunological repertoire
CA2016841C (en)	1989-05-16	1999-09-21	William D. Huse	A method for producing polymers having a preselected activity
CA2057923A1 (en)	1989-05-16	1990-11-17	William D. Huse	Co-expression of heteromeric receptors
US5234814A (en)	1989-06-01	1993-08-10	Du Pont Merck Pharmaceutical Company	Diagnostic assay for alzheimer's disease
EP0411974A1 (en)	1989-07-05	1991-02-06	N.V. Innogenetics S.A.	Monoclonal antibodies to a neurofibrillary tangle antigen
EP0415801A1 (en)	1989-07-05	1991-03-06	N.V. Innogenetics S.A.	Monoclonal antibodies against activated microglial cells
AU6430190A (en)	1989-10-10	1991-05-16	Pitman-Moore, Inc.	Sustained release composition for macromolecular proteins
CA2071867A1 (en)	1989-11-06	1991-05-07	Edith Mathiowitz	Method for producing protein microspheres
GB8928874D0 (en)	1989-12-21	1990-02-28	Celltech Ltd	Humanised antibodies
US5780225A (en)	1990-01-12	1998-07-14	Stratagene	Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
AU7247191A (en)	1990-01-11	1991-08-05	Molecular Affinities Corporation	Production of antibodies using gene libraries
US6075181A (en)	1990-01-12	2000-06-13	Abgenix, Inc.	Human antibodies derived from immunized xenomice
ATE356869T1 (de)	1990-01-12	2007-04-15	Amgen Fremont Inc	Bildung von xenogenen antikörpern
AU7121191A (en)	1990-02-26	1991-10-10	Albert Einstein College Of Medicine Of Yeshiva University	Diagnostic assay for alzheimer's disease
US5753624A (en)	1990-04-27	1998-05-19	Milkhaus Laboratory, Inc.	Materials and methods for treatment of plaquing disease
US5427908A (en)	1990-05-01	1995-06-27	Affymax Technologies N.V.	Recombinant library screening methods
ES2139598T3 (es)	1990-07-10	2000-02-16	Medical Res Council	Procedimientos para la produccion de miembros de parejas de union especifica.
GB9015198D0 (en)	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
DE4022247A1 (de)	1990-07-12	1992-01-16	Hoechst Ag	Verfahren zur extraktiven abtrennung von 2-alkylthio-5-phenylpyrimidinen aus ihren reaktionsgemischen
CA2090126C (en)	1990-08-02	2002-10-22	John W. Schrader	Methods for the production of proteins with a desired function
US5545806A (en)	1990-08-29	1996-08-13	Genpharm International, Inc.	Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en)	1990-08-29	1998-06-23	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en)	1990-08-29	2001-10-09	Genpharm International	Transgenic non-human animals for producing heterologous antibodies
US5877397A (en)	1990-08-29	1999-03-02	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5814318A (en)	1990-08-29	1998-09-29	Genpharm International Inc.	Transgenic non-human animals for producing heterologous antibodies
US5625126A (en)	1990-08-29	1997-04-29	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
US5633425A (en)	1990-08-29	1997-05-27	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en)	1990-08-29	1997-08-26	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69127627T2 (de)	1990-08-29	1998-02-19	Genpharm Int	Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
US6255458B1 (en)	1990-08-29	2001-07-03	Genpharm International	High affinity human antibodies and human antibodies against digoxin
US5698426A (en)	1990-09-28	1997-12-16	Ixsys, Incorporated	Surface expression libraries of heteromeric receptors
DE69129154T2 (de)	1990-12-03	1998-08-20	Genentech, Inc., South San Francisco, Calif.	Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
JPH04252195A (ja)	1991-01-29	1992-09-08	Asahi Chem Ind Co Ltd	モノクローナル抗体及びハイブリドーマ
JP4146512B2 (ja)	1991-03-01	2008-09-10	ダイアックスコープ．	小型タンパク質
AU662148B2 (en)	1991-04-10	1995-08-24	Scripps Research Institute, The	Heterodimeric receptor libraries using phagemids
JPH04320694A (ja)	1991-04-22	1992-11-11	Ono Pharmaceut Co Ltd	ヒトグリア細胞増殖抑制因子に対するモノクローナル抗体
JPH06507404A (ja)	1991-05-01	1994-08-25	ヘンリー　エム．ジャクソン　ファウンデイション　フォー　ザ　アドバンスメント　オブ　ミリタリー　メディスン	感染性の呼吸性疾患の治療方法
EP0519596B1 (en)	1991-05-17	2005-02-23	Merck & Co. Inc.	A method for reducing the immunogenicity of antibody variable domains
JPH04342883A (ja)	1991-05-17	1992-11-30	Sanden Corp	容量可変型斜板式圧縮機
WO1994004679A1 (en)	1991-06-14	1994-03-03	Genentech, Inc.	Method for making humanized antibodies
CA2110799A1 (en)	1991-06-14	1992-12-23	Arnold H. Horwitz	Microbially-produced antibody fragments and their conjugates
DE4122599C2 (de)	1991-07-08	1993-11-11	Deutsches Krebsforsch	Phagemid zum Screenen von Antikörpern
ES2136092T3 (es)	1991-09-23	1999-11-16	Medical Res Council	Procedimientos para la produccion de anticuerpos humanizados.
WO1993008302A1 (en)	1991-10-25	1993-04-29	Itt Automotive Europe Gmbh	Monoclonal antibodies directed against the microtubule-associated protein tau
AU669493B2 (en)	1991-11-12	1996-06-13	University Of Melbourne, The	A method for assaying and treating Alzheimer's disease
US20020009443A1 (en)	1991-12-02	2002-01-24	Vanitha Ramakrishman	Inhibitory immunoglobulin polypeptides to human pdgf beta receptor
PT1024191E (pt)	1991-12-02	2008-12-22	Medical Res Council	Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
JPH07507044A (ja)	1991-12-06	1995-08-03	マックス−プランク−ゲゼルシャフト　ツール　フェルデルング　デル　ヴィッセンシャフテン　エー．ヴェー．	アルツハイマー病の診断および治療用の新規な手段
US7408027B1 (en)	1991-12-06	2008-08-05	Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften	Tools for the diagnosis and treatment of Alzheimer's disease
US5766886A (en)	1991-12-13	1998-06-16	Xoma Corporation	Modified antibody variable domains
US20010029293A1 (en)	1992-01-27	2001-10-11	Icos Corporation	Icam-related protein
US5538845A (en)	1992-02-05	1996-07-23	Athena Neurosciences, Inc.	Beta-amyloid peptide production inhibitors and methods for their identification
US5714350A (en)	1992-03-09	1998-02-03	Protein Design Labs, Inc.	Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5912015A (en)	1992-03-12	1999-06-15	Alkermes Controlled Therapeutics, Inc.	Modulated release from biocompatible polymers
US5733743A (en)	1992-03-24	1998-03-31	Cambridge Antibody Technology Limited	Methods for producing members of specific binding pairs
US5912120A (en)	1992-04-09	1999-06-15	The United States Of America As Represented By The Department Of Health And Human Services,	Cloning, expression and diagnosis of human cytochrome P450 2C19: the principal determinant of s-mephenytoin metabolism
US5604102A (en)	1992-04-15	1997-02-18	Athena Neurosciences, Inc.	Methods of screening for β-amyloid peptide production inhibitors
US5441870A (en)	1992-04-15	1995-08-15	Athena Neurosciences, Inc.	Methods for monitoring cellular processing of β-amyloid precursor protein
US5455169A (en)	1992-06-04	1995-10-03	Alzheimer's Institute Of America, Inc.	Nucleic acids for diagnosing and modeling Alzheimer's disease
US5766846A (en)	1992-07-10	1998-06-16	Athena Neurosciences	Methods of screening for compounds which inhibit soluble β-amyloid peptide production
US5837672A (en)	1992-07-10	1998-11-17	Athena Neurosciences, Inc.	Methods and compositions for the detection of soluble β-amyloid peptide
US6610493B1 (en)	1993-06-17	2003-08-26	Brigham And Women's Hospital	Screening compounds for the ability to alter the production of amyloid-β peptide
JPH07509137A (ja)	1992-07-24	1995-10-12	セル　ジェネシス，インク．	異種抗体の生産
US5639641A (en)	1992-09-09	1997-06-17	Immunogen Inc.	Resurfacing of rodent antibodies
TW258789B (sr)	1992-09-28	1995-10-01	Rohm & Haas
US5605811A (en)	1992-10-26	1997-02-25	Athena Neurosciences, Inc.	Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein
US5891623A (en)	1992-11-09	1999-04-06	Consorzio Per Le Biotecnologie	Diagnosis and treatment of AIDS onset
ZA938243B (en)	1992-11-12	1995-05-04	Hybritech Inc	Altered affinity polypeptides of metal chelate binding antibodies
US6010913A (en)	1992-12-14	2000-01-04	N.V. Innogenetics S.A.	Isolated human tau peptide
US5955317A (en)	1993-01-25	1999-09-21	Takeda Chemical Industries, Ltd.	Antibodies to β-amyloids or their derivatives and use thereof
ATE239797T1 (de)	1993-01-25	2003-05-15	Takeda Chemical Industries Ltd	Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
US5934272A (en)	1993-01-29	1999-08-10	Aradigm Corporation	Device and method of creating aerosolized mist of respiratory drug
CA2115900A1 (en)	1993-02-22	1994-08-23	Gerald W. Becker	Pharmaceutical screens and antibodies
US5840294A (en)	1993-03-29	1998-11-24	Queen's University At Kingston	Method for treating amyloidosis
DE69435171D1 (de)	1993-09-14	2009-01-08	Pharmexa Inc	Pan dr-bindeproteinen zur erhöhung der immunantwort
ATE213507T1 (de)	1993-10-20	2002-03-15	Univ Duke	Methode zur bindung von material an das beta- amyloid-peptid
US5565352A (en)	1993-11-24	1996-10-15	Arch Development Corporation	Deubiquitinating enzyme: compositions and methods
EP0733070A1 (en)	1993-12-08	1996-09-25	Genzyme Corporation	Process for generating specific antibodies
AU1397495A (en)	1993-12-13	1995-07-03	Uab Research Foundation, The	Diagnostic tests and reagents for detecting risk of alzheimer's disease and stroke
US6620915B2 (en)	1993-12-23	2003-09-16	Icos Corporation	Monoclonal antibodies specific for integrin α-d subunit
US6432404B1 (en)	1993-12-23	2002-08-13	Icos Corporation	Methods of inhibiting locomotor damage following spinal cord injury with α D-specific antibodies
US6251395B1 (en)	1993-12-23	2001-06-26	W. Michael Gallatin	Methods of inhibiting inflammation at the site of a central nervous system injury with alphaD-specific antibodies
JPH07209296A (ja)	1994-01-10	1995-08-11	Nikken Chem Co Ltd	抗原及び酵素標識抗体並びにこれらを用いる酵素免疫測定法及び測定用キット
JPH07209295A (ja)	1994-01-10	1995-08-11	Nikken Chem Co Ltd	抗体及び酵素標識抗原並びにこれらを用いる酵素免疫測定法及び測定用キット
US5877399A (en)	1994-01-27	1999-03-02	Johns Hopkins University	Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
ES2201097T3 (es)	1994-01-31	2004-03-16	Trustees Of Boston University	Bibliotecas de anticuerpos policlonales.
JPH07238096A (ja)	1994-02-25	1995-09-12	S R L:Kk	抗ポリユビキチン・モノクローナル抗体およびポリユビキチンの測定方法
JPH07245700A (ja)	1994-03-04	1995-09-19	Minolta Co Ltd	デジタル複写機
US7473423B2 (en)	1994-04-29	2009-01-06	Mayo Foundation For Medical Education And Research	Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
JPH07309900A (ja)	1994-05-20	1995-11-28	Idemitsu Kosan Co Ltd	抗ヒトプロカテプシンｂモノクローナル抗体、それを産生するハイブリドーマ及びそれを用いたヒトプロカテプシンｂ又はヒトカテプシンｂの測定方法
US5516637A (en)	1994-06-10	1996-05-14	Dade International Inc.	Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
JP3388897B2 (ja)	1994-08-31	2003-03-24	三菱重工業株式会社	枚葉印刷機の排紙部
US6018021A (en)	1994-10-19	2000-01-25	The Research Foundation Of State University Of New York	Human transaldolase: an autoantigen with a function in metabolism
US6114133A (en)	1994-11-14	2000-09-05	Elan Pharmaceuticals, Inc.	Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41)
JPH10511957A (ja)	1995-01-05	1998-11-17	ザボードオブリージェンツオブザユニヴァーシティオブミシガン	表面改質ナノ微粒子並びにその製造及び使用方法
US5786180A (en)	1995-02-14	1998-07-28	Bayer Corporation	Monoclonal antibody 369.2B specific for β A4 peptide
US5505576A (en)	1995-03-09	1996-04-09	Crane Carrier Company	Side loader for curbside refuse container
JP3663228B2 (ja)	1995-03-14	2005-06-22	株式会社医学生物学研究所	ニューロプシンに対する抗体
JPH11514333A (ja) *	1995-03-14	1999-12-07	プレーシスファーマスーティカルズインコーポレイテッド	アミロイドの凝集の調節剤
US6091001A (en)	1995-03-29	2000-07-18	Abgenix, Inc.	Production of antibodies using Cre-mediated site-specific recombination
US6130364A (en)	1995-03-29	2000-10-10	Abgenix, Inc.	Production of antibodies using Cre-mediated site-specific recombination
US5705330A (en)	1995-04-14	1998-01-06	Abbott Laboratories	Chemiluminescent immunoassay for antibody detection
US6019968A (en)	1995-04-14	2000-02-01	Inhale Therapeutic Systems, Inc.	Dispersible antibody compositions and methods for their preparation and use
CA2218489A1 (en)	1995-04-21	1996-10-24	Aya Jakobovits	Generation of large genomic dna deletions
EP1978033A3 (en)	1995-04-27	2008-12-24	Amgen Fremont Inc.	Human antibodies derived from immunized xenomice
CA2219486A1 (en)	1995-04-28	1996-10-31	Abgenix, Inc.	Human antibodies derived from immunized xenomice
US5712158A (en)	1995-06-06	1998-01-27	Warner-Lambert Company	Cell line for the rapid expression of functional calcium channels
WO1996040731A1 (en)	1995-06-07	1996-12-19	Mount Sinai School Of Medicine Of The City University Of New York	Pegylated modified proteins
US6717031B2 (en)	1995-06-07	2004-04-06	Kate Dora Games	Method for selecting a transgenic mouse model of alzheimer's disease
JP3767755B2 (ja)	1995-06-23	2006-04-19	エーザイ株式会社	抗ｊｃウイルス抗体
US6127977A (en)	1996-11-08	2000-10-03	Cohen; Nathan	Microstrip patch antenna with fractal structure
PT859841E (pt)	1995-08-18	2002-11-29	Morphosys Ag	Bibliotecas de proteinas/ (poli) peptidos
WO1997007788A2 (en)	1995-08-31	1997-03-06	Alkermes Controlled Therapeutics, Inc.	Composition for sustained release of an agent
WO1997010505A1 (en)	1995-09-14	1997-03-20	The Regents Of The University Of California	ANTIBODIES SPECIFIC FOR NATIVE PrP?Sc¿
FR2740454B1 (fr)	1995-10-26	1997-11-21	Rhone Poulenc Rorer Sa	Peptides capables d'inhiber l'endocytose de l'app et sequences nucleotidiques correspondantes
AUPN649395A0 (en)	1995-11-10	1995-12-07	Ramsay Health Care Pty Ltd	A method for diagnosing alzheimer's disease
FR2741881B1 (fr)	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
WO1997021807A1 (fr)	1995-12-12	1997-06-19	Kyowa Hakko Kogyo Co., Ltd.	Nouveaux adn, nouveaux polypeptides et nouveaux anticorps
JPH09178743A (ja)	1995-12-27	1997-07-11	Oriental Yeast Co Ltd	可溶性ａｐｐの定量法
CA2242343A1 (en)	1996-01-19	1997-07-24	Research Corporation Technologies, Inc.	Methods for the detection of alzheimer's disease
JP2978435B2 (ja)	1996-01-24	1999-11-15	チッソ株式会社	アクリロキシプロピルシランの製造方法
DK0948536T3 (da)	1996-01-30	2007-10-01	Scripps Research Inst	G-protein-koblet receptor med et forstörret extracellulært domæne
BRPI9707379C8 (pt)	1996-02-09	2017-12-12	Abbott Biotech Ltd	composições farmacêuticas compreendendo anticorpo humano recombinante geneticamente engenheirado, e anticorpo humano recombinante geneticamente engenheirado.
US5985320A (en)	1996-03-04	1999-11-16	The Penn State Research Foundation	Materials and methods for enhancing cellular internalization
US5714352A (en)	1996-03-20	1998-02-03	Xenotech Incorporated	Directed switch-mediated DNA recombination
US5882644A (en)	1996-03-22	1999-03-16	Protein Design Labs, Inc.	Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US5874064A (en)	1996-05-24	1999-02-23	Massachusetts Institute Of Technology	Aerodynamically light particles for pulmonary drug delivery
US5855913A (en)	1997-01-16	1999-01-05	Massachusetts Instite Of Technology	Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en)	1996-05-24	1999-11-16	Massachusetts Institute Of Technology	Preparation of particles for inhalation
US6300065B1 (en)	1996-05-31	2001-10-09	Board Of Trustees Of The University Of Illinois	Yeast cell surface display of proteins and uses thereof
US6699658B1 (en)	1996-05-31	2004-03-02	Board Of Trustees Of The University Of Illinois	Yeast cell surface display of proteins and uses thereof
WO1997046678A1 (en)	1996-06-06	1997-12-11	Bayer Corporation	Nucleic acids and polypeptides related to presenilin
WO1999009150A1 (en)	1996-08-15	1999-02-25	Bayer Corporation	Method of introducing modifications into a gene
CA2183901A1 (en)	1996-08-22	1998-02-23	Johanna E. Bergmann	Targets for therapy and diagnosis of alzheimer's disease and down syndrome in humans
US7521531B2 (en)	1996-08-28	2009-04-21	Immunomedics, Inc.	Methods for the purification of stable radioiodine conjugates
JPH1075781A (ja)	1996-08-30	1998-03-24	Sumitomo Electric Ind Ltd	ヒトプロテアソームサブユニットｐ５８蛋白質及びそれに特異的な抗体
EP0834561A1 (en)	1996-09-27	1998-04-08	Rijksuniversiteit te Leiden	A gene related to migraine in man
US5916771A (en)	1996-10-11	1999-06-29	Abgenix, Inc.	Production of a multimeric protein by cell fusion method
WO1998022120A1 (en)	1996-11-19	1998-05-28	The Wistar Institute Of Anatomy & Biology	Diagnostic and therapeutic reagents for alzheimer's disease
JP4215172B2 (ja)	1996-12-03	2009-01-28	アムジェンフレモントインク．	複数のＶ▲下Ｈ▼およびＶ▲下κ▼領域を含むヒトＩｇ遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
US5919687A (en)	1996-12-24	1999-07-06	John Hopkins University	Recombinant N-SMases and nucleic acids encoding same
EP0954282B1 (en)	1997-01-16	2005-01-19	Massachusetts Institute Of Technology	Preparation of particles for inhalation
EP0971946B1 (en)	1997-01-21	2006-07-05	The General Hospital Corporation	Selection of proteins using rna-protein fusions
JPH10210982A (ja)	1997-01-31	1998-08-11	Fuji Yakuhin Kogyo Kk	新規なタンパク質
US6218506B1 (en)	1997-02-05	2001-04-17	Northwestern University	Amyloid β protein (globular assembly and uses thereof)
US20030068316A1 (en)	1997-02-05	2003-04-10	Klein William L.	Anti-ADDL antibodies and uses thereof
US6413940B1 (en)	1997-02-07	2002-07-02	Nymox Corporation	Pharmaceutically active agents that impede the formation of amyloid by impeding the genesis of DMS
US7226730B1 (en)	1997-02-26	2007-06-05	The General Hospital Corporation	Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease
US7045531B1 (en)	1997-03-11	2006-05-16	The General Hospital Corporation	Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
CN1315473C (zh)	1997-03-17	2007-05-16	英国技术集团国际有限公司	治疗组合物
JP2002514919A (ja)	1997-04-04	2002-05-21	バイオサイトダイアグノスティックス，インコーポレイテッド	多価ライブラリーおよびポリクローナルライブラリー
US20020086847A1 (en)	1997-04-09	2002-07-04	Mindset Biopharmaceuticals (Usa)	Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof
US8173127B2 (en)	1997-04-09	2012-05-08	Intellect Neurosciences, Inc.	Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
AU7171098A (en)	1997-05-01	1998-11-24	Board Of Regents, The University Of Texas System	Directed evolution of enzymes and antibodies
US6235883B1 (en)	1997-05-05	2001-05-22	Abgenix, Inc.	Human monoclonal antibodies to epidermal growth factor receptor
EP1860187B1 (en)	1997-05-15	2011-07-13	Genentech, Inc.	Apo-2 receptor
IL133277A0 (en)	1997-07-21	2001-04-30	Rogers Arpi Matossian	Ligands, including antibodies, showing reactivity against endocrine cells
IT1293511B1 (it)	1997-07-30	1999-03-01	Gentili Ist Spa	Anticorpi monoclonali catalitici ad attivita' proteasica per la lisi selettiva della componente proteica di placche e aggregati correlati
US7923216B2 (en)	1997-08-14	2011-04-12	Institut Pasteur	In vivo modulation of neuronal transport
PT1049712E (pt)	1997-08-14	2007-04-30	Pasteur Institut	Proteínas híbridas da toxina do tétano que migram retrogradamente e trans - sinapticamente para o snc
ES2270530T3 (es)	1997-08-26	2007-04-01	Amgen Fremont Inc.	Un procedimiento para inhibir la activacion del completo por la via alternativa.
US6666935B1 (en)	1997-09-09	2003-12-23	The Regents Of The University Of California	Sol-gel manufactured energetic materials
FR2768346B1 (fr)	1997-09-15	2002-04-19	Fond Jean Dausset Ceph	Compose assurant l'inhibition de la preseniline 1 pour la preparation d'un medicament et agent de diagnostic
US20040185039A1 (en)	2002-08-30	2004-09-23	Heinz Kohler	Therapeutic applications of noncovalent dimerizing antibodies
US5989463A (en)	1997-09-24	1999-11-23	Alkermes Controlled Therapeutics, Inc.	Methods for fabricating polymer-based controlled release devices
SE512663C2 (sv)	1997-10-23	2000-04-17	Biogram Ab	Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
WO1999022024A1 (en)	1997-10-24	1999-05-06	Cornell Research Foundation, Inc.	Detection of neurodegenerative diseases
US6710226B1 (en)	1997-12-02	2004-03-23	Neuralab Limited	Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
US7179892B2 (en)	2000-12-06	2007-02-20	Neuralab Limited	Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en)	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6913745B1 (en)	1997-12-02	2005-07-05	Neuralab Limited	Passive immunization of Alzheimer's disease
US6761888B1 (en)	2000-05-26	2004-07-13	Neuralab Limited	Passive immunization treatment of Alzheimer's disease
US6787523B1 (en)	1997-12-02	2004-09-07	Neuralab Limited	Prevention and treatment of amyloidogenic disease
US7964192B1 (en)	1997-12-02	2011-06-21	Janssen Alzheimer Immunotherapy	Prevention and treatment of amyloidgenic disease
US6905686B1 (en)	1997-12-02	2005-06-14	Neuralab Limited	Active immunization for treatment of alzheimer's disease
US6750324B1 (en)	1997-12-02	2004-06-15	Neuralab Limited	Humanized and chimeric N-terminal amyloid beta-antibodies
ES2253839T3 (es)	1997-12-03	2006-06-01	Neuralab, Ltd.	Supresion de cambios relacionados con amiloide beta en la enfermedad de alzheimer.
EP1038958A4 (en)	1997-12-15	2002-10-09	Kyowa Hakko Kogyo Kk	HUMAN NAP1 PROTEIN
US6730778B2 (en)	1997-12-19	2004-05-04	Pharmacia And Upjohn Company	Human sel-10 polypeptides and polynucleotides that encode them
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
US7189703B2 (en)	1998-01-09	2007-03-13	Intracell, Llc	Treatment and diagnosis of alzheimer's disease
DK1054664T3 (da)	1998-02-11	2012-11-05	Bhi Ltd Partnership	Fremgangsmåde til modulering af makrofagaktivering
CA2322749A1 (en)	1998-03-03	1999-09-10	Abgenix, Inc.	Cd147 binding molecules as therapeutics
US6323218B1 (en)	1998-03-11	2001-11-27	The General Hospital Corporation	Agents for use in the treatment of Alzheimer's disease
US20050112543A1 (en)	1998-03-11	2005-05-26	The General Hospital Corporation	Method of screening for drugs useful in treating Alzheimer's disease
US20050059802A1 (en)	1998-04-07	2005-03-17	Neuralab Ltd	Prevention and treatment of amyloidogenic disease
US20050059591A1 (en)	1998-04-07	2005-03-17	Neuralab Limited	Prevention and treatment of amyloidogenic disease
US20020029391A1 (en)	1998-04-15	2002-03-07	Claude Geoffrey Davis	Epitope-driven human antibody production and gene expression profiling
AU3657899A (en)	1998-04-20	1999-11-08	James E. Bailey	Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
US6913756B1 (en)	1998-04-29	2005-07-05	The Uab Research Foundation	Monoclonal antibodies specific for anthrax and peptides derived from the antibodies thereof
NO314086B1 (no)	1998-05-08	2003-01-27	Gemvax As	Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til
WO1999058157A1 (en)	1998-05-08	1999-11-18	Cramer Donald V	Method for inhibiting antibody-mediated rejection of xenogeneic tissues
CA2333203A1 (en)	1998-05-15	1999-11-25	Neurochem Inc.	Methods for modulating neuronal cell death
US20030147882A1 (en)	1998-05-21	2003-08-07	Alan Solomon	Methods for amyloid removal using anti-amyloid antibodies
AU765142B2 (en)	1998-06-01	2003-09-11	Ortho-Mcneil Pharmaceutical, Inc.	Method for treating neurodegenerative disorders
JP2000050885A (ja)	1998-06-02	2000-02-22	Fuji Chemical Industries Ltd	カテプシンに対する抗体およびそれらの利用
ES2198922T3 (es)	1998-06-24	2004-02-01	Advanced Inhalation Research, Inc.	Particulas porosas grandes emitadas por un inhalador.
PT1092767E (pt)	1998-07-02	2007-01-31	Fuso Pharmaceutical Ind	Anticorpo monoclonal específico de protease de serina e sua utilização
EP1105427A2 (en)	1998-08-17	2001-06-13	Abgenix, Inc.	Generation of modified molecules with increased serum half-lives
US7375184B2 (en)	1998-09-01	2008-05-20	Genentech, Inc.	PRO1382 polypeptides
AU767878B2 (en)	1998-09-17	2003-11-27	Otsuka Pharmaceutical Co., Ltd.	LY6H gene
US7083950B2 (en)	1998-09-25	2006-08-01	Regeneron Pharmaceuticals, Inc.	High affinity fusion proteins and therapeutic and diagnostic methods for use
AU5999199A (en)	1998-09-29	2000-04-17	Kyowa Hakko Kogyo Co. Ltd.	Novel antibodies, drugs containing these antibodies and methods for screening compounds by using these antibodies
US6660843B1 (en)	1998-10-23	2003-12-09	Amgen Inc.	Modified peptides as therapeutic agents
EP1731913A3 (en)	1998-12-02	2007-01-17	The Trustees Of The University Of Pennsylvania	Methods and compositions for determining lipid peroxidation levels in oxidant stress syndromes and diseases
JP2002531815A (ja)	1998-12-02	2002-09-24	ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア	オキシダント・ストレス症候群および疾病における脂質の過酸化のレベルを決定する方法および組成物
ATE391724T1 (de)	1998-12-14	2008-04-15	Univ Miami	FRAGMENT DES ßCONNECTIVE TISSUE GROWTH FACTORß (CTGF)
ES2706547T3 (es)	1998-12-23	2019-03-29	Pfizer	Anticuerpos monoclonales humanos para CTLA-4
DE19902550A1 (de)	1999-01-22	2000-07-27	Memorec Medical Molecular Rese	Aspartatprotease
US20030185826A1 (en)	1999-02-24	2003-10-02	Tobinick Edward L.	Cytokine antagonists for the treatment of localized disorders
JP4841038B2 (ja)	1999-03-25	2011-12-21	アボットゲーエムベーハーウントカンパニーカーゲー	ヒトｉｌ−１２に結合するヒト抗体およびその産生法
FR2791263B1 (fr)	1999-03-26	2001-04-27	Halina Zofia Malina	Preparations des medicaments bases sur une reponse immunitaire contre l'accumulation de proteines modifiees par l'acide xanthurenique
ES2571230T3 (es)	1999-04-09	2016-05-24	Kyowa Hakko Kirin Co Ltd	Procedimiento para controlar la actividad de una molécula inmunofuncional
US7527787B2 (en)	2005-10-19	2009-05-05	Ibc Pharmaceuticals, Inc.	Multivalent immunoglobulin-based bioactive assemblies
US6787637B1 (en)	1999-05-28	2004-09-07	Neuralab Limited	N-Terminal amyloid-β antibodies
UA81216C2 (en)	1999-06-01	2007-12-25		Prevention and treatment of amyloid disease
PE20010212A1 (es)	1999-06-01	2001-02-22	Neuralab Ltd	Composiciones del peptido a-beta y procesos para producir las mismas
US20030082554A1 (en)	1999-06-03	2003-05-01	Curagen Corporation	Novel nucleic acid sequences encoding human cell adhesion molecule protein-like polypeptides
JP2000354487A (ja)	1999-06-15	2000-12-26	Takashi Muramatsu	ミッドカイン受容体
US6582945B1 (en)	1999-06-16	2003-06-24	Boston Biomedical Research Institute	Immunological control of β-amyloid levels in vivo
US20020002270A1 (en)	1999-06-16	2002-01-03	Raymond P. Zinkowski	Purified antigen for alzheimer's disease, and methods of obtaining and using same
AU6524500A (en)	1999-08-04	2001-03-05	Northwestern University	Amyloid beta protein (globular assembly and uses thereof)
US7605238B2 (en)	1999-08-24	2009-10-20	Medarex, Inc.	Human CTLA-4 antibodies and their uses
PT1212422E (pt)	1999-08-24	2007-04-30	Medarex Inc	Anticorpos contra citla-4 humana e suas utilizações
ATE283487T1 (de)	1999-09-01	2004-12-15	Evotec Neurosciences Gmbh	Verfahren zur diagnose oder prognose von altersbedingter maculadegeneration
US20040013647A1 (en)	1999-09-03	2004-01-22	Ramot At Tel-Aviv University Ltd.	Methods and compositions for treating a plaque-forming disease
AU784568B2 (en)	1999-09-03	2006-05-04	Ramot At Tel-Aviv University Ltd	Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
US6294171B2 (en)	1999-09-14	2001-09-25	Milkhaus Laboratory, Inc.	Methods for treating disease states comprising administration of low levels of antibodies
JP2001122900A (ja)	1999-10-21	2001-05-08	Yasukazu Tanuma	抗−ＤＮａｓｅγ抗体並びにその製造及び使用
EP1230269A2 (en)	1999-11-03	2002-08-14	Maxygen, Inc.	Antibody diversity generation
KR20020073341A (ko)	1999-11-29	2002-09-23	뉴로켐, 인크.	알츠하이머 및 아밀로이드 관련 질병의 예방 및 치료용 백신
US20070135337A2 (en)	1999-11-29	2007-06-14	Neurochem (International) Limited	Vaccine for the Prevention and Treatment of Alzheimer's and Amyloid Related Diseases
US20020094335A1 (en)	1999-11-29	2002-07-18	Robert Chalifour	Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
US7901689B2 (en)	1999-12-08	2011-03-08	Intellect Neurosciences, Inc.	Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies
EP1752472A3 (en)	1999-12-08	2007-04-25	Intellect Neurosciences, Inc.	Chimeric amyloid beta peptides
JP2001231578A (ja)	1999-12-09	2001-08-28	Kyowa Hakko Kogyo Co Ltd	Ｉｌ−１ファミリーに属する蛋白質
KR20080003945A (ko)	1999-12-23	2008-01-08	뉴로겜 인터내셔널 리미티드	대뇌 아밀로이드 혈관병증을 조절하는 화합물 및 방법
US20030077757A1 (en)	2000-01-11	2003-04-24	Andrews William H.	Method of treating aging-related disorders
AU3167001A (en)	2000-01-17	2001-07-31	Corning O.T.I. S.P.A.	Attenuator integrated with modulator and transmitting module for wdm system using the same
US6806254B2 (en)	2000-02-03	2004-10-19	Nuvelo, Inc.	Methods and materials relating to alpha-2-macroglobulin-like polypeptides and polynucleotides
US20020182660A1 (en)	2000-02-18	2002-12-05	Fong Kei-Lai L.	N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43)
EE200200444A (et)	2000-02-21	2003-12-15	Pharmexa A/S	Meetod autoloogse beeta-amüloidvaigu in vivo mahasurumiseks, amüloidogeense polüpeptiidi analoog, seda kodeeriv nukleiinhappefragment ning kasutamineimmunogeense kompositsiooni valmistamiseks
AU783144B2 (en)	2000-02-21	2005-09-29	H. Lundbeck A/S	Novel method for down-regulation of amyloid
EP3070100B1 (en) *	2000-02-24	2021-07-07	Washington University St. Louis	Humanized antibodies that sequester amyloid beta peptide
EP1130032A1 (en)	2000-02-28	2001-09-05	Gesellschaft für biotechnologische Forschung mbH (GBF)	Single-chain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR)
GB0006398D0 (en)	2000-03-16	2000-05-03	Novartis Ag	Organic compounds
WO2001071351A1 (en)	2000-03-22	2001-09-27	The General Hospital Corporation	Method for treatment of neurodegenerative diseases
AU2001253020A1 (en)	2000-03-30	2001-10-15	Elan Pharmaceuticals, Inc.	Screening markers and methods for neurodegenerative disorders
US20020164668A1 (en)	2000-04-03	2002-11-07	Durham L. Kathryn	Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease
US7371365B2 (en)	2000-04-04	2008-05-13	Mayo Foundation For Medical Education And Research	Methods for detecting parenchymal plaques in vivo
AUPQ712000A0 (en)	2000-04-27	2000-05-18	Medvet Science Pty. Ltd.	Antigenic peptide fragments of VapA protein, and uses thereof
US20080009467A1 (en)	2000-05-01	2008-01-10	Accera, Inc.	Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism
WO2001083525A2 (en)	2000-05-03	2001-11-08	Amgen Inc.	Modified peptides, comprising an fc domain, as therapeutic agents
PT1284998E (pt)	2000-05-22	2005-06-30	Univ New York	Eptideos imunogenicos sinteticos mas nao-amiloidogenicos homologos a beta-amiloides, destinados a induzir uma reaccao imunitaria contra os beta-amiloides e os depositos amiloides
ATE446366T1 (de)	2000-06-22	2009-11-15	Genentech Inc	Agonistische monoklonale antikörper gegen trkc
JP4252195B2 (ja)	2000-06-27	2009-04-08	新日本無線株式会社	高周波線路の変換器
EP2119793A1 (en)	2000-06-28	2009-11-18	Glycofi, Inc.	Methods for producing modified glycoproteins
US7618634B2 (en)	2000-06-28	2009-11-17	Prana Biotechnology Limited	Neurotoxic oligomers
US7449308B2 (en)	2000-06-28	2008-11-11	Glycofi, Inc.	Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US6686449B2 (en)	2000-06-30	2004-02-03	Pharmacia & Upjohn Company	Mutant presenilin 1 polypeptides
JP2004502427A (ja)	2000-07-06	2004-01-29	フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー	異常アルツハイマー病病理と関連する新規ａｐｐ突然変異
EP2082749A3 (en)	2000-07-07	2010-06-30	Bioarctic Neuroscience AB	Prevention and treatment of Alzheimer's disease
AU2007200047B2 (en)	2000-07-07	2009-11-26	Bioarctic Neuroscience Ab	Prevention and treatment of Alzheimer's disease
US6524819B1 (en)	2000-07-11	2003-02-25	Incyte Genomics, Inc.	Down syndrome critical region 1-like proteins
US20020009445A1 (en)	2000-07-12	2002-01-24	Yansheng Du	Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
EP1172378A1 (en)	2000-07-12	2002-01-16	Richard Dr. Dodel	Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
JP2002040023A (ja)	2000-07-28	2002-02-06	Mitsubishi Chemicals Corp	アルツハイマー病の検出方法
US20070009931A1 (en)	2000-08-04	2007-01-11	Kirsch Wolff M	Negative correlation between IRP-2 and Transferrin receptor expression as a diagnostic of Alzheimer's disease
AU9063801A (en)	2000-09-06	2002-03-22	Aventis Pharma Sa	Methods and compositions for diseases associated with amyloidosis
GB0024446D0 (en)	2000-10-05	2000-11-22	Glaxo Group Ltd	Protein
IT1319277B1 (it)	2000-10-24	2003-09-26	Chiesi Farma Spa	Proteine di fusione utili per il trattamento di immunizzazione dellamalattia di alzheimer.
CA2360219A1 (en)	2000-10-27	2002-04-27	Mount Sinai Hospital	Method for detecting alzheimer's disease
EP1363939A2 (en)	2000-11-01	2003-11-26	Insight Biotechnology Limited	Peptides for use in the treatment of alzheimer's disease
DE10055703A1 (de)	2000-11-02	2002-05-08	Peter F Pascoe	Verhinderung der Zellzerstörung und Beseitigung sklrotischer Amyloide verursacht durch organspezifische Antikörperaggregate
WO2002094870A2 (en)	2000-11-02	2002-11-28	Curagen Corporation	Proteins and nucleic acids encoding same
WO2002035987A2 (en)	2000-11-03	2002-05-10	Massachusetts Institute Of Technology	METHODS FOR IDENTIFYING TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE CAUSED BY β-AMYLOID PEPTIDES
US20060062786A1 (en)	2000-11-08	2006-03-23	Human Genome Sciences, Inc.	Antibodies that immunospecifically bind to TRAIL receptors
DE60126980T2 (de)	2000-11-27	2007-11-08	Praecis Pharmaceuticals Inc., Waltham	Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
TWI255272B (en)	2000-12-06	2006-05-21	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
GB0100110D0 (en)	2001-01-04	2001-02-14	Univ Leeds	Modulation of calcium channel activity
DE10101430B4 (de)	2001-01-13	2008-10-02	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Lösliche cyclische Analoga zur Modulation der Amyloidogenese
US20020132758A1 (en)	2001-01-18	2002-09-19	Shell John W.	Method for identifying compounds to treat medical pathologies associated with molecular crystallization
US7320793B2 (en)	2001-01-19	2008-01-22	Cytos Biotechnology Ag	Molecular antigen array
AT500379B8 (de)	2001-02-02	2009-08-15	Axon Neuroscience	Tau-proteine
US7175988B2 (en)	2001-02-09	2007-02-13	Human Genome Sciences, Inc.	Human G-protein Chemokine Receptor (CCR5) HDGNR10
US20040191264A1 (en)	2001-02-19	2004-09-30	Nielsen Klaus Gregorius	Synthetic vaccine agents
WO2002067991A1 (en)	2001-02-23	2002-09-06	Genentech, Inc.	Erodible polymers for injection
JP4659236B2 (ja)	2001-03-01	2011-03-30	大塚製薬株式会社	細胞傷害活性の測定法
US6815175B2 (en)	2001-03-16	2004-11-09	Cornell Research Foundation, Inc.	Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
FR2822238B1 (fr)	2001-03-16	2003-08-29	Gemac	Methode et trousse pour le suivi des maladies neurodegeneratives
DE10117281A1 (de)	2001-04-06	2002-10-24	Inst Molekulare Biotechnologie	Peptid zur Diagnose und Therapie der Alzheimer-Demenz
CA2443770A1 (en)	2001-04-23	2002-10-31	Curagen Corporation	Proteins and nucleic acids encoding same
US6451547B1 (en)	2001-04-25	2002-09-17	Syn X Pharma	Process for differential diagnosis of Alzheimer's dementia and device therefor
ES2318006T3 (es)	2001-04-30	2009-05-01	Eli Lilly And Company	Anticuerpos humanizados que reconocen el peptido beta-amiloide.
DE60229051D1 (de)	2001-04-30	2008-11-06	Lilly Co Eli	Humanisierte antikörper
EP1990057A1 (en)	2001-05-22	2008-11-12	Merck & Co., Inc.	Beta-secretase substrates and uses thereof
US7196163B2 (en)	2001-05-22	2007-03-27	Merk & Co., Inc.	Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
US6906169B2 (en)	2001-05-25	2005-06-14	United Biomedical, Inc.	Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide
ES2228697T3 (es)	2001-06-12	2005-04-16	Wiltfang, Jens	Anticuerpo monoclonal, mab 1e8, que es especifico para los dos primeros aminoacidos de peptidos beta-amiloides y su utilizacion en la deteccion de peptidos beta-amiloides y/o sapp alfa.
US7595378B2 (en)	2001-06-13	2009-09-29	Genmab A/S	Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
CZ200438A3 (cs)	2001-06-13	2004-06-16	Genmab A/S	Název neuveden
US7094884B2 (en)	2001-06-22	2006-08-22	Roche Diagnostics Corporation	Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them
AU2002345843A1 (en)	2001-06-22	2003-01-08	Panacea Pharmaceuticals, Inc.	Compositions and methods for preventing protein aggregation in neurodegenerative diseases
CN1396183A (zh)	2001-07-13	2003-02-12	张小如	降低脑内与老年痴呆有关的淀粉样变纤维的融合人抗体
WO2003008626A2 (en)	2001-07-20	2003-01-30	Oregon Health And Science University	Novel human nucleic acids encoding a pantothenate kinase and methods of use
WO2003014162A1 (en)	2001-08-03	2003-02-20	Medical & Biological Laboratories Co., Ltd.	ANTIBODY RECOGNIZING GM1 GANGLIOSIDE-BOUND AMYLOID β-PROTEIN AND DNA ENCODING THE ANTIBODY
JP4320694B2 (ja)	2001-08-08	2009-08-26	株式会社オーク製作所	多重露光描画装置および多重露光式描画方法
WO2003014329A2 (en)	2001-08-10	2003-02-20	University Of South Florida	Modulation of angiogenesis by a-beta peptides
DK1416965T3 (da)	2001-08-17	2008-05-05	Univ Washington	Assayfremgangsmåde til Alzheimers sygdom
US20040192898A1 (en)	2001-08-17	2004-09-30	Jia Audrey Yunhua	Anti-abeta antibodies
US20040241164A1 (en)	2001-08-17	2004-12-02	Bales Kelly Renee	Use of antibodies having high affinity for soluble ab to treat conditions and diseases related to ass
AU2002329775C1 (en)	2001-08-17	2011-04-07	Eli Lilly And Company	Assay method for alzheimer's disease
US20060073149A1 (en)	2001-08-17	2006-04-06	Bales Kelly R	Rapid improvement of cognition in condition related to abeta
MY144532A (en)	2001-08-20	2011-09-30	Lundbeck & Co As H	Novel method for down-regulation of amyloid
US20030082191A1 (en)	2001-08-29	2003-05-01	Poduslo Joseph F.	Treatment for central nervous system disorders
JP4578098B2 (ja)	2001-10-01	2010-11-10	ダイアックス、コープ	多重鎖真核ディスプレイベクターとその使用
WO2003028543A2 (en)	2001-10-03	2003-04-10	Pfizer Products Inc.	Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease
EP1434053B1 (en)	2001-10-04	2008-03-26	Immuno-Biological Laboratories Co., Ltd.	Reagent for detecting risk factor for alzheimer's disease, detection kit therefor and method of detecting risk factor for alzheimer's disease using the same
WO2003028668A2 (en)	2001-10-04	2003-04-10	Protein Therapeutics, Inc.	Gammaglobulin treatment of immune disorders
GB0124317D0 (en) *	2001-10-10	2001-11-28	Celltech R&D Ltd	Biological products
DE60232265D1 (de)	2001-10-25	2009-06-18	Genentech Inc	Glycoprotein-zusammensetzungen
EP1448601A4 (en)	2001-11-02	2006-04-26	Diagenics Internat Corp	METHOD AND COMPOSITIONS OF MONOCLONAL ANTIBODIES SPECIFIC TO BETA-AMYLOIDE PROTEINS
EP1572894B1 (en)	2001-11-21	2016-04-13	New York University	Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha synuclein, or polyglutamine repeats for induction of an immune response thereto
US7179606B2 (en)	2001-11-23	2007-02-20	Syn X Pharma, Inc.	IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease
US7026129B2 (en)	2001-11-23	2006-04-11	Syn X Pharma, Inc.	IG lambda biopolymer markers predictive of Alzheimers disease
DE10158180A1 (de)	2001-11-28	2003-09-11	Biovision Ag	Verfahren zum Nachweis von Morbus Alzheimer und zur Unterscheidung von Morbus Alzheimer gegenüber anderen demenziellen Erkrankungen, zugehörige Peptide und deren Verwendung
NZ533226A (en)	2001-11-30	2006-05-26	Crucell Holland B	Antigen presenting cell targeting conjugate, an antigen presenting cell contacted with such conjugate, their use for vaccination or as medicament, and methods for their production or generation
CA2478066C (en)	2001-12-04	2009-09-08	Ben-Gurion University Of The Negev Research And Development Authority	Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting
AU2002366355A1 (en)	2001-12-17	2003-06-30	New York State Office Of Mental Health	SEQUESTRATION OF ABeta IN THE PERIPHERY IN THE ABSENCE OF IMMUNOMODULATING AGENT AS A THERAPEUTIC APPROACH FOR THE TREATMENT OR PREVENTION OF BETA-AMYLOID RELATED DISEASES
CA2500462A1 (en)	2001-12-26	2004-03-25	Universidad De Zaragoza	Polyclonal antibodies, preparation method thereof and use of same
US7781396B2 (en)	2002-01-31	2010-08-24	Tel Aviv University Future Technology Development L.P.	Peptides directed for diagnosis and treatment of amyloid-associated disease
US20050153381A1 (en)	2002-02-14	2005-07-14	Marusich Michael F.	Immunocapture of mitochondrial protein complexes
AR038568A1 (es)	2002-02-20	2005-01-19	Hoffmann La Roche	Anticuerpos anti-a beta y su uso
AU2003209446B2 (en)	2002-03-01	2008-09-25	Immunomedics, Inc.	Bispecific antibody point mutations for enhancing rate of clearance
DE10208812A1 (de)	2002-03-01	2003-09-11	Basf Plant Science Gmbh	Verfahren zur Herstellung von ungesättigten Fettsäuren
WO2003074004A2 (en)	2002-03-01	2003-09-12	Szu-Yi Chou	Method of producing antigens
JP2005532276A (ja)	2002-03-05	2005-10-27	ラモトアトテル−アヴィヴユニバーシティリミテッド	免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法
MY139983A (en)	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
CA2492671C (en)	2002-03-22	2012-04-17	Aprogen, Inc.	Humanized antibody and process for preparing same
US20030190689A1 (en)	2002-04-05	2003-10-09	Cell Signaling Technology,Inc.	Molecular profiling of disease and therapeutic response using phospho-specific antibodies
US7122374B1 (en)	2002-04-09	2006-10-17	Takaomi Saido	Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
AU2003226356A1 (en)	2002-04-12	2003-10-27	Ramot At Tel Aviv University Ltd.	Prevention of brain inflammation as a result of induced autoimmune response
NZ536064A (en)	2002-04-19	2008-06-30	Univ Toronto	Immunological methods and compositions for the treatment of alzheimer's disease
AU2003224120A1 (en)	2002-04-24	2003-11-10	Evotec Neurosciences Gmbh	Diagnostic and therapeutic use of ensadin-0477 gene and protein for neurodegenerative diseases
AU2003223474B2 (en)	2002-04-25	2008-09-04	Eli Lilly And Company	Method for treating anxiety and mood disorders in older subjects
US20060257420A1 (en)	2002-04-26	2006-11-16	Cel-Sci Corporation	Methods of preparation and composition of peptide constructs useful for treatment of autoimmune and transplant related host versus graft conditions
DE10221052A1 (de)	2002-05-10	2003-12-04	Transmit Technologietransfer	Wirkstoffe zu Therapie, Diagnostik und Prophylaxe von Erkrankungen, bei denen abnorme Proteinstrukturen auftreten
AU2003243058A1 (en)	2002-05-27	2003-12-12	Bioceros B.V.	Methods for using the cd163 pathway for modulating an immune response
AU2003241131A1 (en)	2002-06-14	2003-12-31	Brainsgate Ltd.	Methods and systems for management of alzheimer's disease
WO2004001422A2 (en)	2002-06-20	2003-12-31	Evotec Neurosciences Gmbh	Diagnostic and therapeutic use of ras-gtpase-activating sh3-domain-binding protein 2 (g3bp2) for neurodegenerative diseases
AU2003260301A1 (en)	2002-06-27	2004-01-19	Evotec Neurosciences Gmbh	Diagnostic and therapeutic use of ensadin-0581 gene and protein for neurodegenerative diseases
SI1517921T1 (sl)	2002-06-28	2006-10-31	Domantis Ltd	Dvojno-specificni ligandi z zvisano serumsko razpolovno dobo
DE60323231D1 (de)	2002-07-12	2008-10-09	Axon Neuroscience	Verkürzte tau proteine
AU2003256578A1 (en)	2002-07-17	2004-02-02	Intellect Neurosciences, Inc.	Peptides and methods of screening immunogenic peptide vaccines against alzheimer's disease
EP1544210A4 (en)	2002-07-18	2006-01-25	Masayasu Okochi	NEW NOTCH ORIGIN POLYPEPTIDES AND BIOMARKERS AND REAGENTS FOR WHICH THEY ARE USED
CA2492930C (en)	2002-07-19	2013-01-08	Cytos Biotechnology Ag	Vaccine compositions containing amyloid beta1-6 antigen arrays
SI1944322T1 (sl)	2002-07-19	2015-06-30	Abbvie Biotechnology Ltd.	Zdravljenje s TNP alfa povezanih bolezni
EP1911765A3 (en)	2002-07-24	2008-04-23	Innogenetics N.V.	Prevention, treatment and diagnosis of diseases associated with Beta-Amyloid formation and/or aggregation
US7250551B2 (en)	2002-07-24	2007-07-31	President And Fellows Of Harvard College	Transgenic mice expressing inducible human p25
SE0202880D0 (sv)	2002-07-26	2002-09-30	Wieslab Ab	Complement system deficiency assay
AU2003259222A1 (en)	2002-07-30	2004-02-16	The Regents Of The University Of California	Method of diagnosing alzheimer's disease
US20040138296A1 (en)	2002-08-12	2004-07-15	Pharmacia Corporation	Amyloid immunization and Cox-2 inhibitors for the treatment of alzheimer's disease
US7252953B2 (en)	2002-08-13	2007-08-07	United States Of America Department Of Veterans Affairs	Method of detecting and preventing Alzheimer's disease, particularly at prodromal and early stages
JP4393382B2 (ja)	2002-08-14	2010-01-06	三菱化学株式会社	中枢性タウ蛋白質特異的抗体
WO2004018997A2 (en)	2002-08-20	2004-03-04	Neurogenetics, Inc.	Methods and compositions for modulating amyloid beta
AU2003266302A1 (en)	2002-08-23	2004-03-11	Proteosys Ag	Method for the diagnosis of alzheimer disease
AU2003270643A1 (en)	2002-09-12	2004-04-30	The Regents Of The University Of California	Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence
US20070010657A1 (en)	2002-09-13	2007-01-11	Rainer Klocke	Cytoplasmic dynein heavy chain 1 genes, expression products, non-human animal model uses in human neurological diseases
US7238488B2 (en)	2002-09-13	2007-07-03	Grace Maresh	Therapeutic and diagnostic applications of perlecan domain I splice variants
AU2003272539A1 (en)	2002-09-17	2004-04-08	New York University	Methods of treating age associated memory impairment (aami), mild cognitive impairment (mci), and dementias with cell cycle inhibitors
JP4242128B2 (ja)	2002-09-18	2009-03-18	武田薬品工業株式会社	脳アミロイドーシス予防・治療薬のスクリーニング方法
WO2004029629A1 (en)	2002-09-27	2004-04-08	Janssen Pharmaceutica N.V.	N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses
US7541440B2 (en)	2002-09-30	2009-06-02	Immunomedics, Inc.	Chimeric, human and humanized anti-granulocyte antibodies and methods of use
JP2006508072A (ja) *	2002-10-01	2006-03-09	ノースウエスタンユニバーシティ	アミロイドベータ由来拡散性リガンド（ＡＤＤＬｓ）、ＡＤＤＬ代替物、ＡＤＤＬ結合性分子、およびそれらの使用
US20070213512A1 (en)	2002-10-01	2007-09-13	Krafft Grant A	Amyloid beta peptide analogs and assemblies thereof
WO2004031241A1 (ja)	2002-10-04	2004-04-15	Techno Network Shikoku Co., Ltd.	ズブチリシン様プロプロテインコンベルターゼ・ｐａｃｅ４に対するモノクローナル抗体及びその利用
CA2501831A1 (en)	2002-10-09	2004-04-22	Activx Biosciences, Inc.	Activity-based probes, and methods of their preparation and use
BR0315157A (pt)	2002-10-09	2005-08-09	Rinat Neuroscience Corp	Métodos de tratar doença de alzheimer empregando-se anticorpos direcionados contra peptìdeo beta amilóide e composições deste
AU2003279312A1 (en)	2002-10-24	2004-05-13	Evotec Neurosciences Gmbh	Diagnostic and therapeutic use of ensadin-0289 gene and protein for neurodegenerative diseases
US20080014194A1 (en)	2003-10-31	2008-01-17	Elan Pharmaceuticals, Inc.	Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
TW200509968A (en)	2002-11-01	2005-03-16	Elan Pharm Inc	Prevention and treatment of synucleinopathic disease
FR2846667B1 (fr)	2002-11-06	2004-12-31	Pasteur Institut	Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives
AU2003295411A1 (en)	2002-11-07	2004-06-03	Celltech R & D	Human monoclonal antibodies to heparanase
WO2004045525A2 (en)	2002-11-15	2004-06-03	Morehouse School Of Medicine	Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation.
DE10256900A1 (de)	2002-11-29	2004-06-24	Nemod Immuntherapie Ag	Tumorspezifische Erkennungsmoleküle
CN100450551C (zh)	2002-11-29	2009-01-14	中国医学科学院基础医学研究所	用于治疗和预防阿尔茨海默病的重组腺相关病毒基因疫苗及其用途
MXPA05005925A (es)	2002-12-02	2006-02-08	Abgenix Inc	Anticuerpos dirigidos a la fosfolipasa a2 y sus usos.
WO2004056318A2 (en)	2002-12-19	2004-07-08	New York University	Method for treating amyloid disease
US20050031651A1 (en)	2002-12-24	2005-02-10	Francine Gervais	Therapeutic formulations for the treatment of beta-amyloid related diseases
CA2511599A1 (en)	2002-12-24	2004-07-15	Neurochem (International) Limited	Therapeutic formulations for the treatment of beta-amyloid related diseases
GB0230203D0 (en)	2002-12-27	2003-02-05	Domantis Ltd	Fc fusion
AT413945B (de)	2003-01-14	2006-07-15	Mattner Frank Dr	Impfstoff für die alzheimer-krankheit
CA2514153A1 (en)	2003-01-22	2004-08-05	Takeda Pharmaceutical Company Limited	Antibody and use thereof
WO2004065569A2 (en)	2003-01-23	2004-08-05	The Regents Of The University Of California	Multi-functional antibodies
EP2270051B1 (en)	2003-01-23	2019-05-15	Ono Pharmaceutical Co., Ltd.	Antibody specific for human PD-1 and CD3
DE10303974A1 (de) *	2003-01-31	2004-08-05	Abbott Gmbh & Co. Kg	Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP1594969B1 (en)	2003-02-01	2015-05-20	Janssen Sciences Ireland UC	Active immunization to generate antibodies to soluble a-beta
CA2515081A1 (en)	2003-02-07	2004-08-19	Protein Design Labs, Inc.	Amphiregulin antibodies and their use to treat cancer and psoriasis
US7575747B2 (en)	2003-02-10	2009-08-18	Applied Molecular Evolution	Aβ binding molecules
US20040242845A1 (en)	2003-02-21	2004-12-02	Nicolau Yves Claude	Methods and compositions comprising supramolecular antigenic constructs and antibodies elicited against them
US8663650B2 (en)	2003-02-21	2014-03-04	Ac Immune Sa	Methods and compositions comprising supramolecular constructs
DE10307603A1 (de)	2003-02-22	2004-09-02	Rieter Ingolstadt Spinnereimaschinenbau Ag	Textilmaschine
US20060188951A1 (en)	2003-02-24	2006-08-24	In Hee Mook	Method for measuring the level of anti-beta-amyloid antibody in body fluids and diagnostic kit for alzheimer's disease using same
US20040223970A1 (en)	2003-02-28	2004-11-11	Daniel Afar	Antibodies against SLC15A2 and uses thereof
US20060104968A1 (en)	2003-03-05	2006-05-18	Halozyme, Inc.	Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
JP4464395B2 (ja)	2003-03-05	2010-05-19	ヘイローザイムインコーポレイテッド	可溶性ヒアルロニダーゼ糖タンパク質（ｓＨＡＳＥＧＰ）、その調製プロセス、使用およびそれを含む薬学的組成物
WO2004085712A2 (en)	2003-03-24	2004-10-07	Penn State Research Foundation	Multi-functional polymeric materials and their uses
CA2520381A1 (en)	2003-03-26	2004-10-14	Sudhir Paul	Proteolytic and covalent antibodies
KR20060054174A (ko)	2003-03-28	2006-05-22	센토코 인코포레이티드	항-아밀로이드 항체, 조성물, 방법 및 용도
CN1189210C (zh)	2003-03-28	2005-02-16	万选才	Cb与生物活性多肽的偶联物及其医药用途
US7632816B2 (en)	2003-03-28	2009-12-15	New York University	Treatment of Alzheimer amyloid deposition
EP1625402B1 (en)	2003-04-09	2014-01-01	Canadian Blood Services	Detection, characterization and treatment of viral infection and methods thereof
EP1469312A1 (en)	2003-04-18	2004-10-20	Friedrich-Alexander-Universität Erlangen-Nürnberg	Diagnosis of Alzheimer's disease
US20060240485A1 (en)	2003-04-24	2006-10-26	Universitat Zurich	Method of monitoring immunotherapy
EP1633316A4 (en)	2003-05-06	2008-04-02	Human Genome Sciences Inc	ANTIBODIES BINDING IMMUNOSIPICALLY TO TRAIL RECEPTORS
US20040223912A1 (en)	2003-05-07	2004-11-11	Montalto Michael Christopher	Compositions and methods for non-invasive imaging of soluble beta-amyloid
ES2246177B1 (es)	2003-05-08	2007-03-01	Universidad De Zaragoza.	Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
EP1480041A1 (en)	2003-05-22	2004-11-24	Innogenetics N.V.	Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
WO2005018536A2 (en)	2003-05-23	2005-03-03	Human Genome Sciences, Inc.	Agonist antibodies that specifically bind the glucagon like peptide-1 receptor
PE20050627A1 (es)	2003-05-30	2005-08-10	Wyeth Corp	Anticuerpos humanizados que reconocen el peptido beta amiloideo
CA2528182A1 (en)	2003-06-06	2005-06-16	Oncomax Acquisition Corp.	Antibodies specific for cancer associated antigen sm5-1 and uses thereof
US7892751B2 (en)	2003-06-09	2011-02-22	Redox-Reactive Reagents Llc	Method of detecting or diagnosing of a neurodegenerative disease or condition
JP4888876B2 (ja)	2003-06-13	2012-02-29	田平武	アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
RU2006101702A (ru)	2003-06-23	2006-09-10	Дженетикс Инститьют, Ллс (Us)	Антитела против интерлейкина-22 и их применения
CA2530927A1 (en)	2003-06-30	2005-01-06	Tel Aviv University Future Technology Development L.P.	Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
US20050009110A1 (en)	2003-07-08	2005-01-13	Xiao-Jia Chang	Methods of producing antibodies for diagnostics and therapeutics
ATE444946T1 (de)	2003-07-15	2009-10-15	Ono Pharmaceutical Co	Verzweigte carbonsäureverbindung und deren verwendung
WO2005012330A2 (en)	2003-07-30	2005-02-10	Brigham And Women's Hospital, Inc.	AMYLOID β-PEPTIDE AND METHODS OF USE
WO2005011599A2 (en)	2003-08-01	2005-02-10	Northwestern University	Antibodies specific for toxic amyloid beta protein oligomers
CA2534898A1 (en)	2003-08-08	2005-02-17	Immunomedics, Inc.	Bispecific antibodies for inducing apoptosis of tumor and diseased cells
JP4239750B2 (ja)	2003-08-13	2009-03-18	セイコーエプソン株式会社	マイクロレンズ及びマイクロレンズの製造方法、光学装置、光伝送装置、レーザプリンタ用ヘッド、並びにレーザプリンタ
WO2005018424A2 (en)	2003-08-18	2005-03-03	Research Foundation For Mental Hygiene, Inc.	Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits
US20050042664A1 (en)	2003-08-22	2005-02-24	Medimmune, Inc.	Humanization of antibodies
WO2005025616A1 (ja)	2003-09-09	2005-03-24	Takeda Pharmaceutical Company Limited	抗体の用途
AU2004272112A1 (en)	2003-09-12	2005-03-24	The Regents Of The University Of California	Monoclonal antibodies specific for conformational epitopes of prefibrillar aggregates
EP1516930A1 (en)	2003-09-16	2005-03-23	Georg-August Universität Göttingen	Cellular model of tauopathies for lead identification and drug discovery
EP1666066A4 (en)	2003-09-19	2007-03-28	Eisai R&D Man Co Ltd	DRUG AGAINST THE DOWN SYNDROME
WO2005027965A1 (en)	2003-09-24	2005-03-31	Peter Krammer	Antibodies against annexins, use thereof for therapy and diagnosis. use of annexins for therapy and diagnosis.
EP1678209B1 (en)	2003-10-07	2011-05-11	Yeda Research And Development Co., Ltd.	Antibodies to nik, their preparation and use
IL158287A0 (en)	2003-10-07	2004-05-12	Yeda Res & Dev	Antibodies to nik, their preparation and use
WO2005037209A2 (en)	2003-10-14	2005-04-28	University Of South Florida	A method for the separation anti-amyloid beta antibody with amyloid beta peptide
EP1681566B1 (en)	2003-10-15	2009-08-12	Sekisui Medical Co., Ltd.	Method of selectively assaying adiponectin multimers
CA2543058A1 (en)	2003-10-20	2005-05-12	Envivo Pharmaceuticals, Inc.	Transgenic flies expressing mutant a.beta.42
WO2005040212A2 (en)	2003-10-24	2005-05-06	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Orthogonal gene switches
PT1694360E (pt)	2003-11-04	2010-12-13	Novartis Vaccines & Diagnostic	Utilização de anticorpos monoclonais antagonistas anti-cd40 para o tratamento de doenças auto-imunes e inflamatórias e da rejeição ao transplante de orgãos
WO2005044847A1 (ja)	2003-11-05	2005-05-19	Toshiharu Suzuki	アルツハイマー病のマーカーペプチド
CA2545152A1 (en)	2003-11-07	2005-05-26	Howard J. Federoff	Compositions and methods of treating neurological diseases
EP1694816B1 (en)	2003-11-07	2013-08-28	Ciphergen Biosystems, Inc.	Biomarkers for alzheimer's disease
WO2005047860A2 (en)	2003-11-08	2005-05-26	Elan Pharmaceuticals, Inc.	Antibodies to alpha-synuclein
KR100556660B1 (ko)	2003-11-11	2006-03-10	국립암센터	Ｈｇｆ의 중화가능 에피토프 및 이에 결합하는 중화 항체
WO2005052002A2 (en)	2003-11-20	2005-06-09	Massachusetts Institute Of Technology	Single-domain antibodies and uses thereof
CN1890266B (zh)	2003-11-28	2012-10-03	阿斯特拉曾尼卡有限公司	抗体
JP4870348B2 (ja)	2003-12-04	2012-02-08	株式会社ペルセウスプロテオミクス	細胞表面抗原に対する抗体取得とその抗原同定
KR101374514B1 (ko) *	2003-12-10	2014-03-13	메다렉스, 인코포레이티드	Ｉｐ―１０ 항체 및 그의 용도
KR101157694B1 (ko)	2003-12-17	2012-06-20	와이어쓰 엘엘씨	면역원성 펩티드 캐리어 컨쥬게이트 및 이의 제조 방법
KR101150548B1 (ko)	2003-12-22	2012-07-06	글락소 그룹 리미티드	신경학적 질환을 치료하기 위한 ｎｏｇｏ-ａ 중화면역글로불린
CA2551110C (en)	2003-12-23	2016-01-19	Tanox, Inc.	Treatment of cancer with novel anti-il 13 monoclonal antibodies
US20080254033A1 (en)	2004-01-21	2008-10-16	Kristen Pierce	Pharmaceutical Compositions Containing Antagonists to Lrp4, Lrp8 or Megalin for Treatment of Diseases
EP1711208A2 (en)	2004-01-28	2006-10-18	Curix APS	Conjugates of amyloid proteins as vaccines for amyloid-related diseases
WO2005080986A1 (en)	2004-02-18	2005-09-01	University Of Iowa Research Foundation	Antibodies to phosphorylated tau, methods of making and methods of use
US7807157B2 (en)	2004-02-20	2010-10-05	Intellect Neurosciences Inc.	Monoclonal antibodies and use thereof
JP4851348B2 (ja)	2004-02-23	2012-01-11	イーライリリーアンドカンパニー	抗Ａβ抗体
JP2008507255A (ja)	2004-03-12	2008-03-13	ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド	ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０
EP1725870A1 (en)	2004-03-18	2006-11-29	Applied Research Systems ARS Holding N.V.	Anti-lipid rafts antibodies
CN1314805C (zh)	2004-03-26	2007-05-09	中国人民解放军军事医学科学院放射与辐射医学研究所	一种新型促细胞凋亡素（apo）及其抗体，制备及用途
NZ550225A (en)	2004-03-30	2010-11-26	Glaxo Group Ltd	Immunoglobulins that bind oncostatin and inhibit or block interaction between hOSM and pg130
AU2005231364A1 (en)	2004-04-02	2005-10-20	Merck & Co., Inc.	Methods for detecting substances which bind to the amyloid precursor protein or beta amyloid fragments, and binding compounds
US20060099211A1 (en)	2004-04-12	2006-05-11	Carmen Monthe	Safer, more potent human immunoglobulin preparations for treating Alzheimer's disease
EP1737969B2 (en)	2004-04-15	2018-09-12	GlycoFi, Inc.	Production of galactosylated glycoproteins in lower eukaryotes
AU2005240991A1 (en)	2004-04-15	2005-11-17	Georgetown University	Use of (4-alkylpiperazinyl) (phenyl) methanones in the treatment of Alzheimer's disease
US7763249B2 (en)	2004-04-27	2010-07-27	Juridical Foundation The Chemo-Sero-Therapeutic Research Institute	Human anti-amyloid β peptide antibody and fragment of said antibody
ITRM20040212A1 (it)	2004-04-30	2004-07-30	Lay Line Genomics Spa	Animale transgenico non umano come modello per malattie neurodegenerative e per la loro diagnosi precoce.
GR1005016B (el)	2004-05-14	2005-10-11	BIOMENTIKA@ΛΑΙΦ@ΣΑΙΕΝΣΙΣ@ΑΝΩΝΥΜΗ@ΕΤΑΙΡΕΙΑ@ΦΑΡΜΑΚΕΥΑΤΙΚΩΝ@ΠΡΟΙΟΝΤΩΝ@(συμμετέχει@σε@ποσοστό@50%)@Α	ΑΝΑΠΤΥΞΗ ΑΝΤΙΣΩΜΑΤΩΝ IgG KAI IgY ΕΝΑΝΤΙΟΝ ΕΙΔΙΚΟΥ ΣΥΝΘΕΤΙΚΟΥ ΕΠΙΤΟΠΙΚΟΥ ΠΑΡΑΓΩΓΟΥ ΤΗΣ HUMANIN (24-ΠΕΠΤΙΔΙΟΥ ΣΧΕΤΙΖΟΜΕΝΟΥ ΜΕ ΤΗ ΝΟΣΟ ALZHEIMER) ΙΚΑΝΩΝ ΝΑ ΑΝΙΧΝΕΥΟΥΝ ΤΟ ΒΙΟΔΡΑΣΤΙΚΟ 24-ΠΕΠΤΙΔΙΟ.
JP2008500286A (ja)	2004-05-14	2008-01-10	ノースウエスタンユニバーシティ	Ａｄｄｌ受容体を含む組成物、関連する組成物、および関連する方法
EP1766396B1 (en)	2004-06-07	2010-08-11	Ramot at Tel-Aviv University Ltd.	Method of passive immunization against disease or disorder characterized by amyloid aggregation with diminished risk of neuroinflammation
AR049390A1 (es)	2004-06-09	2006-07-26	Wyeth Corp	Anticuerpos contra la interleuquina-13 humana y usos de los mismos
US20060018896A1 (en)	2004-06-10	2006-01-26	University Of Leicester	Methods for treating conditions associated with lectin-dependent complement activation
US20050276806A1 (en)	2004-06-15	2005-12-15	Advanced Biotherapy, Inc.	Treatment of autism
AU2005287392A1 (en)	2004-06-18	2006-03-30	Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Anti-lympho- plus anti-monocytes globulin preparation for inhibiting immune responses
SE0401601D0 (sv)	2004-06-21	2004-06-21	Bioarctic Neuroscience Ab	Protofibril specific antibodies and uses thereof
JP2008513732A (ja)	2004-07-02	2008-05-01	ノースウエスタンユニバーシティ	アミロイドβ（Ａｂｅｔａ）の病理学的なアセンブリを標的とするモノクローナル抗体
WO2006005588A1 (en)	2004-07-12	2006-01-19	Geneprot, Inc.	Polypeptide species useful for the treatment of neurological disorders
AT500483B1 (de)	2004-07-13	2006-01-15	Mattner Frank Dr	Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung
CN1721437A (zh)	2004-07-13	2006-01-18	中南大学	一种与Tau蛋白相关的多肽抗原及抗体
AT413946B (de)	2004-07-13	2006-07-15	Mattner Frank Dr	Impfstoff gegen die alzheimer-krankheit
WO2006006172A2 (en)	2004-07-15	2006-01-19	Ramot At Tel Aviv University Ltd.	Use of anti-amyloid agents for treating and typing pathogen infections
US7955812B2 (en)	2004-07-19	2011-06-07	The General Hospital Corporation	Methods of diagnosing alzheimer's disease by detecting antibodies to cross-linked β-amyloid oligomers
EP1781644B1 (en)	2004-07-28	2008-05-28	Schering Corporation	Macrocyclic beta-secretase inhibitors
KR101068289B1 (ko)	2004-07-30	2011-09-28	리나트 뉴로사이언스 코퍼레이션	아밀로이드-베타 펩티드에 대해 지시된 항체 및 이의 사용 방법
WO2006015622A1 (en)	2004-08-09	2006-02-16	Cellzome Ag	Treatment of neurodegenerative diseases by the use of degs inhibitors
AU2005272396A1 (en)	2004-08-11	2006-02-16	Mitsubishi Chemical Corporation	Antibody and utilization of the same
JP2008508893A (ja)	2004-08-11	2008-03-27	エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー	形質膜ａｔｐアーゼの診断及び治療への使用
DE102004039326A1 (de)	2004-08-12	2006-02-16	Abbott Gmbh & Co. Kg	Neue medizinische Verwendungen und Verfahren
US7335491B2 (en)	2004-08-27	2008-02-26	Wyeth Research Ireland Limited	Production of anti-abeta
US20060246075A1 (en)	2004-09-29	2006-11-02	Marc Mercken	Anti-amyloid antibodies, compositions, methods and uses
DE602005026219D1 (de)	2004-10-01	2011-03-17	Max Planck Gesellschaft	Gegen das säugetier-eag1-ionenkanalprotein gerichtete antikörper
WO2006039327A2 (en)	2004-10-01	2006-04-13	Merck & Co., Inc.	Methods of treatment or prophylaxis of amyloidogenic diseases of the eye or optic nerve
US7807804B2 (en)	2004-10-05	2010-10-05	Wyeth Llc	Methods and compositions for improving recombinant protein production
CN101052718A (zh)	2004-10-06	2007-10-10	森启	变异型淀粉样蛋白质
AU2005293752A1 (en)	2004-10-13	2006-04-20	Ablynx N.V.	Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease
US20080044356A1 (en)	2004-10-22	2008-02-21	Regents Of The University Of Minnesota	Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof
BRPI0516962A (pt)	2004-10-25	2008-09-30	Univ Northwestern	anticorpo isolado, ou fragmento do mesmo, composição farmacêutica, métodos para prevenir a ligação de ligantes difundìveis derivados de abeta a um neurÈnio, para inibir a constituição de ligantes difundìveis, para bloquear a fosforilação de proteìna, para tratar profilaticamente ou terapeuticamente uma doença, para identificar um agente terapêutico, para detectar ligantes difundìveis, e para diagnosticar uma doença, e, kit para detectar ligantes difundìveis
WO2007050359A2 (en)	2005-10-21	2007-05-03	Merck & Co., Inc.	Anti-addl monoclonal antibody and use thereof
WO2006047670A2 (en)	2004-10-26	2006-05-04	Wyeth	Methods for assessing antibodies to neurodegenerative disease-associated antigens
AU2005297854A1 (en)	2004-10-28	2006-05-04	Sanko Junyaku Co., Ltd.	Method of examining Alzheimer's disease and diagnostic reagent
WO2006050041A2 (en)	2004-10-28	2006-05-11	Ramot At Tel Aviv University Ltd.	Methods for reducing or inhibiting brain inflammation or for promoting neurogenesis
US7709208B2 (en)	2004-11-08	2010-05-04	New York University	Methods for diagnosis of major depressive disorder
WO2006052924A2 (en)	2004-11-08	2006-05-18	Nanobac Life Sciences	Methods and compositions for protein-hydroxy apatite complexes and their application in testing and modulating immunological system including a novel in vitro test for the detection of antibodies against calcium binding protein-hydroxy apatite complexes
CN1772766A (zh)	2004-11-12	2006-05-17	中国科学院上海生命科学研究院	抗细胞凋亡相关乙酰胆碱酯酶单克隆抗体及其用途
WO2006053428A1 (en)	2004-11-17	2006-05-26	Joanne Mclaurin	Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation
US20060257396A1 (en)	2004-12-15	2006-11-16	Jacobsen Jack S	Abeta antibodies for use in improving cognition
ES2434732T3 (es)	2004-12-15	2013-12-17	Janssen Alzheimer Immunotherapy	Anticuerpos para beta-amiloide humanizados para su uso en mejorar la cognición
WO2006066233A1 (en)	2004-12-15	2006-06-22	Neuralab Limited	An immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies
US20060153772A1 (en)	2004-12-15	2006-07-13	Wyeth	Contextual fear conditioning for predicting immunotherapeutic efficacy
ES2396555T3 (es)	2004-12-15	2013-02-22	Janssen Alzheimer Immunotherapy	Anticuerpos que reconocen péptido beta amiloide
JP2006166879A (ja)	2004-12-20	2006-06-29	Japan Health Science Foundation	Ａｂ−ｄｉｐ、並びにアルツハイマー病の予防及び治療剤
MY146381A (en)	2004-12-22	2012-08-15	Amgen Inc	Compositions and methods relating relating to anti-igf-1 receptor antibodies
WO2006067792A2 (en)	2004-12-22	2006-06-29	Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science	Aldolase autoantigens useful in diagnosis and treatment of alzheimer's disease
US20090074775A1 (en)	2004-12-22	2009-03-19	David Michael Holtzman	Use Of Anti-AB Antibody To Treat Traumatic Brain Injury
EP1676859A1 (en)	2004-12-30	2006-07-05	Pevion Biotech Ltd.	Immunogenic compositions of cyclic peptides derived from the beta-amyloid peptide
EP1853299A4 (en)	2005-01-14	2009-11-11	Univ California	COMPOSITIONS AND METHODS FOR INHIBITING THE PRESENCE OF DRUGS AND DIAGNOSING OR TREATING DRUG-INDUCED DISEASES
US7906625B2 (en)	2005-01-24	2011-03-15	Amgen Inc.	Humanized anti-amyloid antibody
GT200600031A (es)	2005-01-28	2006-08-29		Formulacion anticuerpo anti a beta
JP2006213621A (ja)	2005-02-02	2006-08-17	Japan Health Science Foundation	Ａｄｏｐｌｉｎタンパク質、およびその利用
US20070082350A1 (en)	2005-02-09	2007-04-12	Philip Landfield	Assay and method for diagnosing and treating alzheimer's disease
US7731962B2 (en)	2005-02-14	2010-06-08	Merck & Co., Inc.	Anti-ADDL monoclonal antibody and use thereof
US7700099B2 (en)	2005-02-14	2010-04-20	Merck & Co., Inc.	Non-immunostimulatory antibody and compositions containing the same
GB0503434D0 (en)	2005-02-18	2005-03-30	Senexis Ltd	Amyloid-binding peptides, analogues and uses thereof
DK3332808T3 (da)	2005-03-03	2020-12-14	Immunomedics Inc	Humaniserede L243-antistoffer
CA2600929A1 (en)	2005-03-04	2006-09-14	Biogen Idec Ma Inc.	Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues
CN101365717A (zh)	2005-03-05	2009-02-11	艾博特股份有限两合公司	筛选方法、纯化非扩散A-β寡聚体的方法、抗所述非扩散A-β寡聚体的选择性抗体以及制备所述抗体的方法
US20080152644A1 (en)	2005-03-07	2008-06-26	Ho-Juhn Song	Genes Involved in Neurodegenerative Conditions
ES2259270B1 (es)	2005-03-09	2007-11-01	Consejo Superior De Investigaciones Cientificas	Metodo de diagnostico in vitro de la enfermedad de alzheimer mediante un anticuerpo monoclonal.
WO2006099543A2 (en)	2005-03-15	2006-09-21	The Regents Of The University Of California	Methods for assessing antibody-mediated cytotoxicity
WO2006100679A2 (en)	2005-03-22	2006-09-28	Quark Pharmaceuticals, Inc.	Recombinant antibodies against human type ii transglutaminase and uses thereof
JP2006265189A (ja)	2005-03-24	2006-10-05	Kyoto Univ	βアミロイドペプチド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法
ES2318918B1 (es)	2005-04-01	2010-02-16	Biotherapix Molecular Medicines, S.L.U.	Anticuerpos humanos con capacidad de union al peptido beta-amiloide y sus aplicaciones.
US8227194B2 (en)	2005-04-08	2012-07-24	University Of Maryland, Baltimore	Monoclonal antibodies with binding specificity for response gene to complement 32 (RGC-32)
US20060241038A1 (en)	2005-04-20	2006-10-26	Eisai Co., Ltd.	Therapeutic agent for Abeta related disorders
US20060240007A1 (en)	2005-04-22	2006-10-26	Genentech, Inc.	Method for treating dementia or Alzheimer's disease
PE20061323A1 (es)	2005-04-29	2007-02-09	Rinat Neuroscience Corp	Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
WO2006119449A2 (en)	2005-05-04	2006-11-09	Vectorlogics, Inc.	Modified adenovirus containing a stabilized antibody
CN101171031B (zh)	2005-05-05	2011-09-28	默沙东公司	防止和治疗阿尔茨海默病的肽偶联物组合物和方法
US20090172827A1 (en)	2005-05-27	2009-07-02	Johannes Pohlner	Kcnn3 as diagnostic and therapeutic target for neurodegenerative diseases
EP1907566A4 (en)	2005-05-27	2008-12-10	Memory Pharm Corp	ALZHEIMER TRANSGENIC MOUSE MODEL VECTORS AND USES THEREOF
BRPI0610938A2 (pt)	2005-06-06	2010-08-03	Wyeth Corp	anticorpos monoclonais anti-trkb e usos dos mesmos
BRPI0611599A2 (pt)	2005-06-17	2011-02-22	Elan Pharma Int Ltd	método para purificar uma protéina de ligação a beta, e, proteìna de ligação a beta
EP1921137A4 (en)	2005-06-21	2011-01-26	Med & Biological Lab Co Ltd	ANTIBODIES WITH INHIBITOR EFFECT ON THE FORMATION OF AMYLOID FIBRILLES
TW200726482A (en)	2005-06-30	2007-07-16	Merck & Co Inc	Method for preparing a covalently cross linked oligomer of amyloid beta peptides
TW200726774A (en)	2005-06-30	2007-07-16	Merck & Co Inc	Composition and method for producing stable amyloid beta oligomers
CN101495509B (zh)	2005-07-08	2015-04-22	比奥根艾迪克Ma公司	Sp35抗体及其用途
US20090297534A1 (en)	2005-07-13	2009-12-03	Sudhir Paul	Catalytic Immunoglobulins BBK32 and Uses Therefor
WO2007011834A2 (en)	2005-07-15	2007-01-25	The Regents Of The University Of California	Compounds and method for the diagnosis and treatment of amyloid associated diseases
US20070092517A1 (en)	2005-08-10	2007-04-26	Oklahoma Medical Research Foundation	Truncated memapsin 2 compositions and treatments
JP2009505640A (ja)	2005-08-11	2009-02-12	− ロジャーズ、アルピマトシアン	自己免疫疾患の治療及び診断のためのｔｃｒ−ｖベータ関連ペプチド
EP1945668A4 (en)	2005-08-15	2009-07-22	Arana Therapeutics Ltd	SYNTHETIC ANTIBODIES WITH FRAMEWORK REGIONS OF NEUWELTPRIMATEN
WO2007022416A2 (en)	2005-08-18	2007-02-22	Ramot At Tel Aviv University Ltd.	Single chain antibodies against beta-amyloid peptide
US7612181B2 (en)	2005-08-19	2009-11-03	Abbott Laboratories	Dual variable domain immunoglobulin and uses thereof
JP2007077103A (ja)	2005-09-16	2007-03-29	Yokohama City Univ	アルツハイマー病の予防又は治療剤
CN101321863A (zh)	2005-10-03	2008-12-10	阿斯利康(瑞典)有限公司	具有受调控的血浆半衰期的融合蛋白
DK1940881T3 (en)	2005-10-11	2017-02-20	Amgen Res (Munich) Gmbh	COMPOSITIONS WITH ARTICLE CROSS-SPECIFIC ANTIBODIES AND APPLICATIONS THEREOF
US20070092508A1 (en)	2005-10-21	2007-04-26	Recombiant Technologies, Llc	Detoxification depot for Alzheimer's disease
SI1940457T1 (sl)	2005-10-21	2013-04-30	Catalyst Biosciences, Inc.	Modificirane proteaze, ki inhibirajo komplementno aktivacijo
ES2428089T3 (es)	2005-11-01	2013-11-05	Novartis Ag	Usos de anticuerpos anti-cd40
WO2007059135A2 (en)	2005-11-10	2007-05-24	Satoris, Inc.	Methods of treating alzheimer's disease
US8316104B2 (en)	2005-11-15	2012-11-20	California Institute Of Technology	Method and apparatus for collaborative system
US20080014596A1 (en)	2005-11-16	2008-01-17	Jasna Jerecic	ADDL Binding to Hippocampal Neurons
WO2007062088A1 (en)	2005-11-22	2007-05-31	The Trustees Of The University Of Pennsylvania	Antibody treatment of alzheimer's and related diseases
CN101528770A (zh)	2005-11-30	2009-09-09	艾博特公司	制备重组形式的人β-淀粉样蛋白的方法和这些蛋白质的应用
BRPI0619249A2 (pt)	2005-11-30	2011-09-20	Abbott Lab	anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
ES2453941T5 (es)	2005-11-30	2017-05-31	Abbvie Inc.	Anticuerpos monoclonales contra la proteína beta amiloide y usos de los mismos
EP1973951A2 (en)	2005-12-02	2008-10-01	Genentech, Inc.	Binding polypeptides with restricted diversity sequences
WO2007067512A2 (en)	2005-12-08	2007-06-14	Merck & Co., Inc.	Method for identifying modulators of adprh useful for treating alzheimer's disease
KR101591206B1 (ko)	2005-12-12	2016-02-04	에이씨 이뮨 에스.에이.	치료적 특성을 갖는 베타 1-42 특이적인 단일클론성 항체
CA2632828C (en)	2005-12-12	2012-07-10	F. Hoffmann-La Roche Ag	Antibodies against amyloid beta with glycosylation in the variable region
ES2407429T3 (es)	2005-12-12	2013-06-12	Ac Immune S.A.	Vacuna terapéurica
US7763245B2 (en)	2005-12-15	2010-07-27	Genentech, Inc.	Methods and compositions for targeting polyubiquitin
US20080058276A1 (en)	2006-01-13	2008-03-06	Cornell Research Foundation, Inc.	Alzheimer's disease therapeutics based on pin-1 catalyzed conformational changes in phosphorylated amyloid precursor protein
EP1811304A1 (en)	2006-01-18	2007-07-25	Friedrich-Alexander-Universität Erlangen-Nürnberg	Large Aß-peptide binding particles (LAPS) in diagnosis and therapy of Alzheimer's dementia
CN1329413C (zh)	2006-01-23	2007-08-01	南京医科大学	一种治疗或预防老年性痴呆的抗体及其表达载体和在制药中的应用
ES2409844T3 (es)	2006-01-30	2013-06-28	Grifols Therapeutics Inc.	Metodo para el tratamiento y la profilaxis de enfermedades relacionadas con la deposicion de amiloide utilizando IgM
GB0601976D0 (en)	2006-02-01	2006-03-15	Merck Sharp & Dohme	Proteins
WO2007088712A1 (ja)	2006-02-02	2007-08-09	National University Corporation Nagoya University	神経細胞の細胞死阻害剤及びスクリーニング方法
JP2009533016A (ja)	2006-02-06	2009-09-17	イーランファーマスーティカルズ、インコーポレイテッド	プレセニリン１特異的阻害剤及びそれらの使用
CN101370826A (zh)	2006-02-09	2009-02-18	诺瓦提斯公司	抗分泌型卷曲相关蛋白-4(sfrp-4)的抗体
JP2009531299A (ja)	2006-02-21	2009-09-03	オクラホマメディカルリサーチファウンデーション	ＡｐｏＥ受容体へのＡｐｏＥの結合のインヒビターによるアルツハイマー病の処置
US20070196367A1 (en)	2006-02-22	2007-08-23	Valentin Dinu	Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
JP5097695B2 (ja)	2006-02-22	2012-12-12	株式会社林原	抗アミロイドβペプチド抗体産生誘導用のペプチドワクチン
ZA200807228B (en)	2006-02-24	2009-11-25	Chiesi Farma Spa	Anti-amyloid immunogenic compositions, methods and uses
US20100196932A1 (en)	2006-03-02	2010-08-05	The Board Of Trustees Of The University Of Illinois	Yeast Reporter System
JP5823663B2 (ja)	2006-03-03	2015-11-25	プロミスニューロサイエンシズインコーポレイテッド	ミスフォールドｓｏｄ１媒介疾患を処置および検出するための方法および組成物
WO2007109107A2 (en)	2006-03-17	2007-09-27	The Trustees Of Columbia University In The City Of New York	Atf4 as a therapeutic target in alzheimers disease and other neurological disorders
BRPI0708998A2 (pt)	2006-03-21	2011-06-21	Wyeth Corp	anticorpo que se liga especificamente ao rage; anticorpo quimérico ou um fragmento de ligação rage do mesmo; anticorpo humanizado ou um fragmento de ligação rage do mesmo; anticorpo humanizado que se liga especificamente ao rage ou um fragmento de ligação rage do mesmo; anticorpo que se liga especificamente ao rage e bloqueia a ligação de um parceiro corporal rage; ácido nucléico isolado; método de tratamento de um indivìduo que tem uma doença ou transtorno relacionado com rage; método de tratamento de sepse ou choque séptico em um indivìduo humano; método de tratamento de listeriose sistêmica em um indivìduo humano; e método de inibir a ligação de um parceiro de ligação rage (rage-bp), o rage em um indivìduo mamìfero
RU2429244C2 (ru)	2006-03-23	2011-09-20	Байоарктик Ньюросайенс Аб	Улучшенные селективные в отношении протофибрилл антитела и их применение
WO2007112288A2 (en)	2006-03-23	2007-10-04	Mount Sinai School Of Medicine	Cardiovascular composition and use the same for the treatment of alzheimers disease
CA2541522A1 (en)	2006-03-28	2007-09-28	E. Rick Preddie	A double elisa for alzheimer's disease (ad) with applications for therapeutic vaccines to stop the disease
SI1996621T1 (sl)	2006-03-30	2010-04-30	Glaxo Group Ltd	Protitelesa proti amiloidnemu peptidu beta
FR2899107B1 (fr)	2006-03-30	2008-06-13	Neurokin Entpr Unipersonnelle	Utilisation de la (s)-roscovitine pour la fabrication d'un medicament
JP2009532674A (ja)	2006-03-31	2009-09-10	ザレジェンツオブザユニヴァースティオブカリフォルニア	神経変性障害及びアルツハイマー病を治療するための、並びに正常な記憶を改善するための方法と組成物
WO2007119685A1 (ja)	2006-04-13	2007-10-25	Sanko Junyaku Co., Ltd.	β－アミロイドの血中分解速度測定によるアルツハイマー病の検定方法及び診断試薬
CN101058608B (zh)	2006-04-21	2011-02-23	杜如昱	人类抗Aβ1-32淀粉样蛋白抗体、其纯化方法及用途
US8008026B2 (en)	2006-04-21	2011-08-30	Peoplebio, Inc.	Methods for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide through three-dimensional interactions
US20090220524A1 (en)	2006-04-25	2009-09-03	The University Of Tokyo	Therapeutic agents for alzheimer's disease and cancer
GB0608386D0 (en)	2006-04-27	2006-06-07	Senexis Ltd	Compounds
CA2650376A1 (en)	2006-04-27	2007-11-08	The Mclean Hospital Corporation	Treatment and screening methods for promoting neurogenesis
US20100168120A1 (en)	2006-04-28	2010-07-01	Neuromedix Inc.	Salts of pyridazine compounds
JP2007300856A (ja)	2006-05-11	2007-11-22	Hiroshi Mori	アミロイドタンパク質模倣物
US20070292895A1 (en)	2006-05-19	2007-12-20	Xiao-Ping Shi	Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts
WO2008042024A2 (en)	2006-06-01	2008-04-10	Elan Pharmaceuticals, Inc.	Neuroactive fragments of app
JP4933159B2 (ja)	2006-06-02	2012-05-16	国立大学法人金沢大学	アルツハイマー病の診断方法
US7479550B2 (en)	2006-06-02	2009-01-20	The Board Of Regents Of The University Of Texas System	Amyloid β gene vaccines
US7427342B2 (en)	2006-06-02	2008-09-23	General Electric Company	Method and apparatus for shifting current distribution in electrodeionization systems
US20090264359A1 (en)	2006-06-16	2009-10-22	Cornelis Petrus Maria Van Kessel	Fplr-1 inhibitors for use in diseases involving amyloid-induced inflammatory events (flipr and flipr-like) and immunecomplex-mediated diseases
TW200815469A (en)	2006-06-23	2008-04-01	Astrazeneca Ab	Compounds
US20100028351A1 (en)	2006-06-29	2010-02-04	Marc Mercken	Anti-amyloid antibodies, compositions, methods and uses
CA2655029A1 (en)	2006-07-06	2008-01-10	Roskamp Research, Llc	Compounds and combinations thereof for inhibiting beta-amyloid production and methods of use thereof
WO2008008939A2 (en)	2006-07-13	2008-01-17	Parker Hannifin Corporation	Emi absorbing gap filling material
EP2046833B9 (en)	2006-07-14	2014-02-19	AC Immune S.A.	Humanized antibody against amyloid beta
WO2008008463A2 (en)	2006-07-14	2008-01-17	Trustees Of Columbia University In The City Of New York	METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING SAPPβ
DE602006005806D1 (de)	2006-07-28	2009-04-30	Vista Ventures Gmbh	Verfahren zum Nachweis der amyloid-beta Oligomere in Körperflüssigkeiten
US7705475B2 (en)	2006-08-03	2010-04-27	Stats Chippac Ltd.	Integrated circuit package system
CA2657847A1 (en)	2006-08-04	2008-02-07	Lonza Biologics Plc	Method for predicting protein aggregation and designing aggregation inhibitors
US20090123488A1 (en)	2006-08-14	2009-05-14	Thymon, Llc	Compositions and methods for the treatment and prophylaxis of Alzheimer's disease
US7741446B2 (en)	2006-08-18	2010-06-22	Armagen Technologies, Inc.	Fusion antibodies that cross the blood-brain barrier in both directions
WO2008051326A2 (en)	2006-08-21	2008-05-02	President And Fellows Of Harvard College	Identification of contactins and l1- cams as ligands for the amyloid precursor protein
WO2008070229A2 (en)	2006-08-28	2008-06-12	Case Western Reserve University	Detection of pathogenic aggregates of protein in a sample by homologous elisa
EP2081429A4 (en)	2006-08-31	2010-01-06	Biogen Idec Inc	PROCESS FOR PERIPHERAL ADMINISTRATION OF NOGO RECEPTOR POLYPEPTIDES
US8372399B2 (en)	2006-08-31	2013-02-12	Cardiac Pacemakers, Inc.	Bispecific antibodies and agents to enhance stem cell homing
US20080118938A1 (en)	2006-09-06	2008-05-22	Lisbell Estrada	Methods and Compositions for the Detection of Protein Folding Disorders
WO2008028939A1 (en)	2006-09-08	2008-03-13	Vib Vzw	Means and methods for the production of amyloid oligomers
WO2008030251A1 (en)	2006-09-08	2008-03-13	Georgetown University	Deglycosylated anti-amyloid beta antibodies
ES2307396B1 (es)	2006-09-14	2009-09-30	Fundacion Para Investigaciones Neurologicas (Fin)	Sistemas de eliminacion de sustancias neurotoxicas causantes de enfermedades neurodegenerativas mediante su atrapamiento selectivo por inmunoafinidad en el liquido cefalo-raquideo circulante.
US7375190B2 (en)	2006-09-19	2008-05-20	National Yang-Ming University	Recombinant protein and method of screening for agents that modulate polypeptide aggregation
PL2074145T3 (pl)	2006-10-02	2017-11-30	Ac Immune S.A.	Humanizowane przeciwciało przeciw amyloidowi beta
US9382327B2 (en)	2006-10-10	2016-07-05	Vaccinex, Inc.	Anti-CD20 antibodies and methods of use
US20100104577A1 (en)	2006-10-10	2010-04-29	Golde Todd E	Methods and materials related to anti-a (beta) antibodies
JP5153114B2 (ja)	2006-10-12	2013-02-27	知宏千葉	新規のアルツハイマー病検出方法
US20080113444A1 (en)	2006-10-17	2008-05-15	Pray Todd R	Method for detecting oligermization of soluble amyloid beta oligomers
GB0620735D0 (en)	2006-10-18	2006-11-29	Ares Trading Sa	Proteins
WO2008051017A1 (en)	2006-10-24	2008-05-02	Seoul National University Industry Foundation	A cleavage agent selectively acting on soluble assembly of amyloidogenic peptide or protein
RU2486296C2 (ru)	2006-10-27	2013-06-27	Эбботт Байотекнолоджи Лтд.	КРИСТАЛЛИЧЕСКИЕ АНТИТЕЛА ПРОТИВ hTNFα
EP2083621A4 (en)	2006-11-20	2010-03-24	Satori Pharmaceuticals Inc	MODULATORS OF AMYLOID BETA PRODUCTION
WO2008064244A2 (en)	2006-11-20	2008-05-29	The Trustees Of Columbia University In The City Of New York	Phosphoinositide modulation for the treatment of neurodegenerative diseases
EP2102165A2 (en)	2006-11-24	2009-09-23	AC Immune S.A.	N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's
US8455626B2 (en)	2006-11-30	2013-06-04	Abbott Laboratories	Aβ conformer selective anti-aβ globulomer monoclonal antibodies
WO2008143708A2 (en)	2006-12-07	2008-11-27	Mayo Foundation For Medical Education And Research	Methods and materials related to anti-amyloid antibodies
CN101553504A (zh)	2006-12-11	2009-10-07	豪夫迈·罗氏有限公司	Aβ抗体胃肠外制剂
US20100028333A1 (en)	2006-12-15	2010-02-04	Getty Krista L	Receptor for amyloid beta and uses thereof
EP2104682B1 (en)	2007-01-11	2016-09-21	Michael Bacher	Diagnosis and treatment of alzheimer's and other neurodementing diseases
US20080220449A1 (en)	2007-02-08	2008-09-11	Oligomerix, Inc.	Biomarkers and assays for Alzheimer's disease
KR100806914B1 (ko)	2007-02-14	2008-02-22	경북대학교 산학협력단	퇴행성 신경질환의 예방 및 치료를 위한 리포칼린 2의 신규한 용도
WO2008104386A2 (en)	2007-02-27	2008-09-04	Abbott Gmbh & Co. Kg	Method for the treatment of amyloidoses
EP2125015A1 (en)	2007-02-27	2009-12-02	Abbott GmbH & Co. KG	Method for the treatment of amyloidoses
GB0704394D0 (en)	2007-03-07	2007-04-11	Senexis Ltd	Compounds
US20090022728A1 (en)	2007-03-09	2009-01-22	Rinat Neuroscience Corporation	Methods of treating ophthalmic diseases
EP1978035A1 (en)	2007-04-05	2008-10-08	Hans-Knöll-Institut Leibniz-Institut für Naturstoff-Forschung	Anti-amyloid antibodies and their use in diagnosis and therapy of amyloid diseases
EP2656839A1 (en)	2007-04-12	2013-10-30	Waratah Pharmaceuticals, Inc.	Use of Cyclohexanehexol Derivatives in the Treatment of Ocular Diseases
AU2008242648B2 (en)	2007-04-18	2013-09-12	Janssen Alzheimer Immunotherapy	Prevention and treatment of cerebral amyloid angiopathy
WO2008129023A2 (en)	2007-04-19	2008-10-30	Vib Vzw	Oligonucleotide compositions for the treatment of alzheimer's disease
WO2008134034A1 (en)	2007-04-26	2008-11-06	Yale University	Prion protein as a receptor for amyloid-beta oligomers
US20090175847A1 (en)	2007-05-30	2009-07-09	Abbott Laboratories	Humanized antibodies to ab (20-42) globulomer and uses thereof
WO2008150467A1 (en)	2007-05-30	2008-12-11	The Regents Of The University Of Michigan	Screening assays for inhibitors of beta amyloid peptide ion channel formation
US20090232801A1 (en)	2007-05-30	2009-09-17	Abbot Laboratories	Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
TWI453217B (zh)	2007-06-12	2014-09-21	Ac Immune Sa	抗β類澱粉蛋白單株抗體
CL2008001741A1 (es)	2007-06-12	2008-11-21	Genentech Inc	Anticuerpo quimerico o humanizado o fragmento de los mismos que se unen especificamente a por lo menos un epitope en la proteina beta-amiloide; molecula de acido nucleico que lo codifica; composicion que lo comprende; y su uso para tratar enfermedades asociados con la formacion de placas amiloides.
EP2009445A1 (en)	2007-06-29	2008-12-31	Institut Pasteur	Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications
CN101084909A (zh)	2007-07-03	2007-12-12	福建医科大学附属协和医院	人参皂苷Rg1的新用途
MX2010000369A (es)	2007-07-12	2010-07-02	Acumen Pharmaceuticals Inc	Metodos para mejorar la funcion cognitiva usando compuestos no peptidicos.
US8962677B2 (en)	2007-07-12	2015-02-24	Acumen Pharmaceuticals, Inc.	Methods of restoring cognitive ability using non-peptidic compounds
CA2692801A1 (en)	2007-07-12	2009-01-15	Acumen Pharmaceuticals, Inc.	Methods of inhibiting the formation of amyloid-.beta. diffusable ligands using acylhydrazide compounds
EP2170322B1 (en)	2007-07-12	2013-02-13	Acumen Pharmaceuticals, Inc.	METHODS OF MODIFYING AMYLOID ß OLIGOMERS USING NON-PEPTIDIC COMPOUNDS
NZ601858A (en)	2007-10-05	2014-03-28	Genentech Inc	Methods and compositions for diagnosis and treatment of amyloidosis
SG178809A1 (en)	2007-10-05	2012-03-29	Genentech Inc	Use of anti-amyloid beta antibody in ocular diseases
GB0719559D0 (en)	2007-10-05	2007-11-14	Senexis Ltd	Compounds
US9403902B2 (en)	2007-10-05	2016-08-02	Ac Immune S.A.	Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
CN101152576A (zh)	2007-10-15	2008-04-02	王延江	防治阿尔茨海默病的药物
CR20170001A (es)	2008-04-28	2017-08-10	Genentech Inc	Anticuerpos anti factor d humanizados
WO2010010469A2 (en)	2008-07-25	2010-01-28	Abbott Gmbh & Co. Kg	Abeta (x-38..43) oligomers, and processes, compositions, and uses thereof
MX2011000975A (es)	2008-07-25	2011-05-25	Abbott Lab	Analogos de peptido b amiloide, oligomeros de los mismos, procedimientos para preparar y composiciones que comprenden dichos analogos u oligomeros, y sus usos.
ES2665495T3 (es)	2009-02-25	2018-04-26	Academia Sinica	Anticuerpos anti-CemX capaces de unirse a mIgE humana sobre linfocitos B
EP2558494B1 (en)	2010-04-15	2018-05-23	AbbVie Inc.	Amyloid-beta binding proteins
CN103079741B (zh)	2010-06-14	2015-04-01	依赛彼公司	自动设置mig/mag焊接的焊接参数的方法和用于执行所述方法的控制器
EP3533803B1 (en)	2010-08-14	2021-10-27	AbbVie Inc.	Anti-amyloid-beta antibodies
CN107074924A (zh)	2014-07-07	2017-08-18	艾伯维德国有限责任两合公司	基于突变蛋白β淀粉样蛋白(Aβ)氨基酸序列的免疫原性产物及其用途

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KR20140087058A (ko)	2014-07-08
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AU2006320392B2 (en)	2013-01-17
ES2453941T5 (es)	2017-05-31
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JP5486808B2 (ja)	2014-05-07
SG2014013437A (en)	2014-07-30
BRPI0619357A8 (pt)	2017-02-14
CN101506236A (zh)	2009-08-12
IL228535A (en)	2015-08-31
PL1976877T5 (pl)	2017-09-29
CA2631195A1 (en)	2007-06-07
KR101906161B1 (ko)	2018-10-11
RU2008126241A (ru)	2010-01-10
CA2631195C (en)	2016-04-05
IL231857A (en)	2016-03-31
US10323084B2 (en)	2019-06-18
IL289365A (en)	2022-02-01
KR20150061042A (ko)	2015-06-03
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JP2016053017A (ja)	2016-04-14
JP2013047228A (ja)	2013-03-07
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KR20160124908A (ko)	2016-10-28
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IL191587A (en)	2014-09-30
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IL243807B (en)	2020-03-31
DK1976877T3 (da)	2014-03-31
PT1976877E (pt)	2014-04-29
KR101667623B1 (ko)	2016-10-19
WO2007064972A3 (en)	2007-11-01
IL231857A0 (en)	2014-05-28
CN101506236B (zh)	2012-12-12
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EP1976877B2 (en)	2016-10-05
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AU2006320392A1 (en)	2007-06-07
US20160159891A1 (en)	2016-06-09
IL210058A0 (en)	2011-07-31
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RS53270B (sr)	2014-08-29
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US20220017607A1 (en)	2022-01-20
US20180066044A1 (en)	2018-03-08
BRPI0619357A2 (pt)	2011-09-27
PL1976877T3 (pl)	2014-06-30
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