[go: up one dir, main page]

PT87769A - Transcripton-based nucleic acid amplification detection systems - Google Patents

Transcripton-based nucleic acid amplification detection systems

Info

Publication number
PT87769A
PT87769A PT87769A PT8776988A PT87769A PT 87769 A PT87769 A PT 87769A PT 87769 A PT87769 A PT 87769A PT 8776988 A PT8776988 A PT 8776988A PT 87769 A PT87769 A PT 87769A
Authority
PT
Portugal
Prior art keywords
nucleic acid
primer
transcripton
duplex
acid amplification
Prior art date
Application number
PT87769A
Other languages
English (en)
Other versions
PT87769B (pt
Inventor
Thomas Raymond Gingeras
Ulrich Merten
Deborah Yantis Kwoh
Original Assignee
Siska Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26744190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT87769(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Siska Diagnostics Inc filed Critical Siska Diagnostics Inc
Publication of PT87769A publication Critical patent/PT87769A/pt
Publication of PT87769B publication Critical patent/PT87769B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6867—Replicase-based amplification, e.g. using Q-beta replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Indicating And Signalling Devices For Elevators (AREA)
  • Air Bags (AREA)
PT87769A 1987-06-19 1988-06-17 Processo de preparacao de um acido nucleico de cadeia dupla e processo de amplificacao de um segmento de acido nucleico PT87769B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6414187A 1987-06-19 1987-06-19
US20297888A 1988-06-06 1988-06-06

Publications (2)

Publication Number Publication Date
PT87769A true PT87769A (pt) 1989-05-31
PT87769B PT87769B (pt) 1992-10-30

Family

ID=26744190

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87769A PT87769B (pt) 1987-06-19 1988-06-17 Processo de preparacao de um acido nucleico de cadeia dupla e processo de amplificacao de um segmento de acido nucleico

Country Status (17)

Country Link
EP (2) EP0368906B2 (pt)
JP (1) JP2843586B2 (pt)
KR (1) KR960014107B1 (pt)
AT (2) ATE114335T1 (pt)
BR (1) BR8807097A (pt)
DE (2) DE3852177T3 (pt)
DK (1) DK175614B1 (pt)
ES (1) ES2009286A6 (pt)
FI (1) FI93743C (pt)
GR (1) GR880100396A (pt)
HU (1) HU216317B (pt)
IE (1) IE65089B1 (pt)
IL (1) IL86724A (pt)
NO (1) NO303068B1 (pt)
NZ (1) NZ225077A (pt)
PT (1) PT87769B (pt)
WO (1) WO1988010315A1 (pt)

Families Citing this family (432)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356774A (en) * 1986-04-16 1994-10-18 The Trustees Of Columbia University In The City Of New York Replicative RNA-based amplification/detection systems
WO1989001050A1 (en) * 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
WO1989006700A1 (en) * 1988-01-21 1989-07-27 Genentech, Inc. Amplification and detection of nucleic acid sequences
WO1989007149A1 (en) * 1988-01-28 1989-08-10 Mayo Foundation For Medical Education And Research Genomic amplification with direct sequencing
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
CA1339991C (en) * 1988-09-08 1998-08-11 The Trustees Of Columbia University Replicative rna-based amplification/detection system
EP0433363A4 (en) * 1988-09-08 1992-05-06 The Salk Institute For Biological Studies Replicative rna-based amplification detection systems
EP0446305B1 (en) * 1988-12-05 1996-05-08 The Salk Institute For Biological Studies Systems for amplification/detection of target nucleic acids
BR8907830A (pt) * 1988-12-16 1991-10-22 Siska Diagnostics Inc Processo para preparar uma dna de filamento duplo que codifica uma sequencia que corresponde a uma sequencia objetivada de acido nucleico e processo util para deteccao de pelo menos uma sequencia de acido nucleico objetivada especifica
US5237016A (en) * 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
AU5404890A (en) * 1989-02-14 1990-09-05 Biogen, Inc. Oligonucleotide primer pairs for sequence independent gene amplification and methods which employ them
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5480784A (en) * 1989-07-11 1996-01-02 Gen-Probe Incorporated Nucleic acid sequence amplification methods
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5219727A (en) * 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
DE3929030A1 (de) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh Verfahren zur vermehrung von nukleinsaeuren
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US7585512B1 (en) 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
US5645994A (en) * 1990-07-05 1997-07-08 University Of Utah Research Foundation Method and compositions for identification of species in a sample using type II topoisomerase sequences
JPH04141098A (ja) * 1990-09-29 1992-05-14 Shimadzu Corp Ｒｎａ検出用試薬及びそれを用いたｒｎａの検出方法
AU9115891A (en) * 1990-11-14 1992-06-11 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
WO1992012261A1 (en) 1990-12-31 1992-07-23 Promega Corporation Nucleic acid amplification with dna-dependent rna polymerase activity of rna replicases
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
US5169766A (en) * 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
DE69214243T2 (de) * 1991-09-23 1997-02-06 Pfizer Verfahren für die Detektion von spezifische mRNS und DNS in Zellen
DE4132133A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen herstellung von ribonukleinsaeuren
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
CA2135073C (en) * 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5614389A (en) * 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
AU670116B2 (en) * 1992-08-04 1996-07-04 Gen-Probe Incorporated Nucleic acid sequence amplification
US5834202A (en) * 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
AU686616B2 (en) 1993-03-26 1998-02-12 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
WO1995003430A1 (en) * 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
DE69431240T2 (de) * 1993-12-01 2003-04-17 Toyo Boseki K.K., Osaka Verfahren zur ampflifizierung und zum nachweis bestimmter nukleinsäuresequenzen mittels thermostabiler enzyme
FR2714062B1 (fr) * 1993-12-22 1996-02-16 Bio Merieux Promoteur modifié pour ARN polymérase, sa préparation et ses applications.
JPH09510351A (ja) 1994-03-16 1997-10-21 ジェン−プローブ・インコーポレイテッド 等温鎖置換核酸増幅法
US5863724A (en) * 1994-04-13 1999-01-26 Baylor College Of Medicine Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US5606043A (en) * 1994-11-03 1997-02-25 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5849879A (en) * 1994-11-03 1998-12-15 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5789169A (en) * 1994-11-03 1998-08-04 Regents Of The University Of California Methods for the diagnosis of glaucoma
US5654141A (en) * 1994-11-18 1997-08-05 Thomas Jefferson University Amplification based detection of bacterial infection
DE4441626A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verfahren zum besonders sensitiven Nachweis von Nukleinsäuren
US6001610A (en) * 1994-11-23 1999-12-14 Roche Diagnostics, Gmbh Method for the particularly sensitive detection of nucleic acids
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
JP4241929B2 (ja) 1996-05-22 2009-03-18 ジェン―プローブ・インコーポレーテッド Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｋａｎｓａｓｉｉを検出するための組成物および方法
US5914229A (en) * 1996-06-14 1999-06-22 Sarnoff Corporation Method for amplifying a polynucleotide
JPH1028585A (ja) * 1996-07-16 1998-02-03 Toyobo Co Ltd 耐熱性リボヌクレアーゼｈを用いる核酸増幅法
US6132954A (en) * 1996-08-20 2000-10-17 Baylor College Of Medicine Methods of screening for agents that delay a cell cycle and compositions comprising era and an analogue of wild-type era
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
US6071493A (en) 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
US6379929B1 (en) 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
AU5794498A (en) 1996-12-10 1998-07-03 Genetrace Systems, Inc. Releasable nonvolatile mass-label molecules
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
JP3968810B2 (ja) * 1997-01-24 2007-08-29 東ソー株式会社 核酸配列分析方法
US6475724B1 (en) 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
GB9703146D0 (en) 1997-02-14 1997-04-02 Innes John Centre Innov Ltd Methods and means for gene silencing in transgenic plants
US6713300B1 (en) 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
ES2563643T3 (es) 1997-04-01 2016-03-15 Illumina Cambridge Limited Método de secuenciación de ácido nucleico
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
DE69836012T2 (de) 1997-05-02 2007-04-05 Gen-Probe Inc., San Diego Zwei-schritt hybridisierung und einfang von einem polynukleotid
EP1002138B1 (en) 1997-08-08 2004-11-17 Organon Teknika B.V. Nucleic acid sequences that can be used as primers and probes in the amplification and detection of all subtypes of hiv-1
EP1040192B1 (en) 1997-12-18 2006-08-09 Monsanto Technology LLC Insect-resistant transgenic plants and methods for improving delta-endotoxin activity against insects
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
ATE220427T1 (de) * 1998-01-27 2002-07-15 Cytocell Ltd Verfahren zum nachweis von nukleinsäure- zielsequenzen mittels in vitro transkription von einem rna-promoter
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
EP1930078A1 (en) 1998-05-01 2008-06-11 Gen-Probe Incorporated Method for agitating the contents of a container
DE19834948A1 (de) * 1998-08-03 2000-02-17 Monika Jecht Verfahren zur spezifischen Detektion von RNA
US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
EP1131633A2 (en) 1998-11-16 2001-09-12 Board of Regents, The University of Texas System Hiv-specific t-cell induction
US6156515A (en) * 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
WO2000066780A2 (en) 1999-04-30 2000-11-09 University Of Florida Adeno-associated virus-delivered ribozyme compositions and methods of use
EP1471926B8 (en) 1999-06-01 2011-09-21 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence
EP1190097A2 (en) 1999-06-22 2002-03-27 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
JP3929775B2 (ja) 1999-09-13 2007-06-13 ニューゲン テクノロジーズ， インコーポレイテッド ポリヌクレオチド配列の線形等温増幅のための方法および組成物
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
DE60133190T2 (de) 2000-04-21 2009-04-02 CORIXA CORP., Wilmington Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen
MXPA02012735A (es) 2000-06-26 2004-04-20 Nugen Tgechnologies Inc Metodos y composiciones para la amplificacion de acido nucleico a base de transcripcion.
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
AR029540A1 (es) 2000-06-28 2003-07-02 Corixa Corp COMPOSICIONES Y METODOS PARA EL DIAGNoSTICO Y LA TERAPIA DE CA NCER DE PULMoN
DE60045932D1 (de) 2000-09-01 2011-06-16 Gen Probe Inc HIV-1-Sequenzverstärkung zur Erkennung von Sequenzen in Zusammenhang mit Wirkstoffresistenz-Mutationen
ES2300375T3 (es) 2000-10-23 2008-06-16 Gen-Probe Incorporated Composiciones y metodos para la deteccion del virus de la inmunodeficiencia humana 2 (hiv-2).
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
WO2002048402A2 (en) 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
WO2002070735A2 (en) * 2001-03-07 2002-09-12 Biomerieux B.V. Method for the amplification and detection of dna using a transcription based amplification
WO2002072773A2 (en) 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
KR20030082535A (ko) 2001-03-09 2003-10-22 뉴젠 테크놀로지스 인코포레이티드 Ｒｎａ 서열의 증폭을 위한 방법 및 조성물
JP2005504513A (ja) 2001-05-09 2005-02-17 コリクサ コーポレイション 前立腺癌の治療及び診断のための組成物及び方法
EP1399541A4 (en) 2001-05-22 2005-04-13 Univ Chicago Single Strand DNA Dependent RNA VIRION N4 POLYMERASE
EP1908851A3 (en) 2001-09-19 2008-06-25 Intergenetics Incorporated Genetic analysis for stratification of cancer risk
EP1436423A4 (en) 2001-09-19 2005-04-13 Intergenetics Inc GENETIC ANALYSIS TO STRATIFY CANCER RISK
US8512953B2 (en) 2001-09-24 2013-08-20 One Lambda Diagnostic probe detection system
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
CA2476755C (en) 2001-12-17 2014-08-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
ATE529512T1 (de) 2002-02-01 2011-11-15 Life Technologies Corp Doppelsträngige oligonukleotide
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
ES2594333T3 (es) 2002-05-17 2016-12-19 Becton, Dickinson And Company Sistema automatizado para aislar, amplificar y detectar una secuencia blanco de ácidos nucleicos
WO2003106714A1 (en) 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
US6916474B2 (en) 2002-07-15 2005-07-12 Board Of Regents, The University Of Texas System Antibodies with increased affinities for anthrax antigens
KR101170653B1 (ko) 2002-08-12 2012-08-03 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
AU2002951411A0 (en) 2002-09-16 2002-09-26 The University Of Sydney Genotype screen
AU2003298605B2 (en) 2002-10-16 2007-10-18 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
US7074561B2 (en) 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
MXPA05007295A (es) 2003-01-06 2005-09-30 Corixa Corp Ciertos compuestos de fosfato de aminoalquil glucosaminida y su uso.
US6852494B2 (en) 2003-01-10 2005-02-08 Linden Technologies, Inc. Nucleic acid amplification
ATE448302T1 (de) 2003-01-29 2009-11-15 454 Corp Nukleinsäureamplifikation auf basis von kügelchenemulsion
EP2374900B1 (en) 2003-03-07 2016-07-13 Rubicon Genomics, Inc. Polynucleotides for the amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process
EP2390352A1 (en) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
AU2004230494A1 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
CA2528572C (en) 2003-06-10 2020-08-25 The Trustees Of Boston University Gene expression analysis of airway epithelial cells for diagnosing lung cancer
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
JP4871722B2 (ja) 2003-07-25 2012-02-08 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー 固定試料からｒｎａを調製するための方法および組成物
EP2128270B1 (en) 2003-08-08 2012-10-03 Genenews Inc. Osteoarthritis biomarkers and uses thereof
ATE489481T1 (de) 2003-09-12 2010-12-15 Univ Cincinnati Verfahren zur risikobeurteilung, überlebensvorhersage und behandlung von herzversagen und anderen leiden auf der grundlage von polymorphismen adrenerger rezeptoren
WO2005054516A2 (en) 2003-11-26 2005-06-16 Advandx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
WO2005061738A1 (en) 2003-12-19 2005-07-07 Gen-Probe Incorporated Compositions, methods and kits for detecting the nucleic acids of hiv-1 and hiv-2
CA2497324A1 (en) 2004-02-17 2005-08-17 Affymetrix, Inc. Methods for fragmenting and labelling dna
CA2556911C (en) 2004-02-19 2013-07-30 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
EP1598428A1 (en) 2004-05-18 2005-11-23 Georg Dewald Methods and kits to detect Hereditary angioedema type III
US20090081243A1 (en) 2004-06-03 2009-03-26 Athlomics Pty Ltd. Agents and methods for diagnosing stress
ES2392445T3 (es) 2004-07-13 2012-12-10 Gen-Probe Incorporated Composiciones y métodos para la detección de ácido nucleico del virus de la hepatitis A
EP1970454B1 (en) 2004-08-27 2012-09-19 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
US7713697B2 (en) 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
EP1630236A3 (de) 2004-08-30 2006-05-03 FBF- Förderverein Biologieforschung der Deutschen Schweineproduktion e.V. Hernia inguinalis/scrotalis assozieerte Genomregionen
CA2581086C (en) 2004-09-14 2023-11-07 The Regents Of The University Of Colorado, A Body Corporate Method for treatment with bucindolol based on genetic targeting
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
US20060068380A1 (en) 2004-09-30 2006-03-30 Gen-Probe Incorporated Assay for detecting and quantifying HIV-1
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
EP1652580A1 (en) 2004-10-29 2006-05-03 Affymetrix, Inc. High throughput microarray, package assembly and methods of manufacturing arrays
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
EP2280085A3 (en) 2004-11-01 2011-02-23 George Mason University Compositions and methods for diagnosing colon disorders
CA2582661C (en) 2004-11-09 2015-08-11 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
CA2592179C (en) 2005-02-07 2012-04-03 Gen-Probe Incorporated Compositions and methods for detecting group b streptococci
CN103497993A (zh) 2005-02-07 2014-01-08 基因信息公司 轻度骨关节炎生物标志物及其用途
DK1853706T3 (da) 2005-02-18 2011-03-07 Gen Probe Inc Prøve-fremstillingsfremgangsmåde med et alkali-chock
EP1874955A4 (en) 2005-02-28 2009-05-06 Bioquest Inc METHODS FOR EXECUTING DIRECT ENZYMATIC REACTIONS USING NUCLEIC ACID MOLECULES
PL1856257T3 (pl) 2005-03-05 2012-03-30 Seegene Inc Procesy wykorzystujące oligonukleotyd o podwójnej specyficzności oraz oligonukleotyd o podwójnej specyficzności
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
AU2006236621B2 (en) 2005-04-14 2011-10-06 The Trustees Of Boston University Diagnostic for lung disorders using class prediction
EP1712557A1 (en) 2005-04-14 2006-10-18 RWTH Aachen New s-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases
JP4773513B2 (ja) 2005-05-06 2011-09-14 ジェン−プローブ・インコーポレーテッド Ａ型及びｂ型インフルエンザウイルスの核酸を検出するための組成物及びアッセイ
WO2006121134A1 (ja) 2005-05-13 2006-11-16 Wako Pure Chemical Industries, Ltd. マイコバクテリウム・カンサシ検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・カンサシの検出方法
US8202727B2 (en) 2005-05-17 2012-06-19 Ozgene Pty Ltd. Sequential cloning system
US20090264305A1 (en) 2005-07-07 2009-10-22 Athlomics Pty Ltd. Polynucleotide Marker Genes and their Expression, for Diagnosis of Endotoxemia
US7494788B2 (en) 2005-07-11 2009-02-24 Molecular Kinetics, Inc. Entropic bristle domain sequences and their use in recombinant protein production
US7838646B2 (en) 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
AU2006304721B2 (en) 2005-10-17 2012-01-19 Gen-Probe Incorporated Compositions and methods to detect Legionella pneumophila nucleic acid
AU2006304883A1 (en) 2005-10-21 2007-04-26 Genenews Inc. Method and apparatus for correlating levels of biomarker products with disease
WO2007053358A2 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Methods for identifying compounds of interest using encoded libraries
EP1785434A1 (en) 2005-11-11 2007-05-16 Ludwig-Maximilians-Universität München Targeting and tracing of antigens in living cells
WO2007059179A1 (en) 2005-11-14 2007-05-24 Gen-Probe Incorporated Parametric calibration method
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
EP2605018A1 (en) 2006-03-09 2013-06-19 The Trustees of the Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
JP5239853B2 (ja) 2006-03-13 2013-07-17 和光純薬工業株式会社 変異遺伝子の検出方法
ES2393758T3 (es) 2006-03-15 2012-12-27 Micronics, Inc. Ensayos integrados de ácidos nucleicos
US8188256B2 (en) 2006-05-02 2012-05-29 Wako Pure Chemical Industries, Ltd. Primer and probe for detection of Mycobacterium intracellulare
AU2007249286B2 (en) 2006-05-12 2013-06-13 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
BR122015030334B8 (pt) 2006-05-25 2018-05-22 Monsanto Technology Llc processo para seleção de uma planta de soja resistente à ferrugem asiática da soja
US20120196827A1 (en) 2006-06-12 2012-08-02 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
CA2663034C (en) 2006-09-15 2016-05-03 Ottawa Health Research Institute Oncolytic rhabdovirus
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
WO2008066655A2 (en) 2006-11-02 2008-06-05 Yale University Assessment of oocyte competence
US8293684B2 (en) 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
US8067179B2 (en) 2006-11-30 2011-11-29 Research Development Foundation Immunoglobulin libraries
ATE522608T1 (de) 2006-12-18 2011-09-15 Wako Pure Chem Ind Ltd Primer und sonde zum nachweis von mycobacterium avium sowie verfahren zum nachweis von mycobacterium avium unter verwendung des primers bzw. der sonde
CA2672951A1 (en) 2006-12-20 2008-07-03 Bayer Healthcare Llc Hydroxy methyl phenyl pyrazolyl urea compound useful in the treatment of cancer
EP3095873B1 (en) 2006-12-21 2018-04-18 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
EP2121983A2 (en) 2007-02-02 2009-11-25 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
US8183359B2 (en) 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
PT2191001T (pt) 2007-04-09 2016-09-23 Univ Florida Composições com vetores raav possuindo proteínas da cápside modificadas com tirosina e métodos para o seu uso
DK2076289T3 (da) 2007-04-13 2015-02-09 Dana Farber Cancer Inst Inc Fremgangsmåder til behandling af cancerresistens over for ErbB-lægemider
CA2685675C (en) 2007-05-01 2016-02-16 Research Development Foundation Immunoglobulin fc libraries
AU2008343380B2 (en) 2007-12-26 2012-07-12 Gen-Probe Incorporated Compositions and methods to detect Candida albicans nucleic acid
WO2009099037A1 (ja) 2008-02-08 2009-08-13 Wako Pure Chemical Industries, Ltd. クラミドフィラ・キャビエ検出用プライマー及びプローブ、並びにこれを用いたクラミドフィラ・キャビエの検出方法
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
EP2677041A3 (en) 2008-02-19 2014-04-09 MDxHealth SA Detection and prognosis of lung cancer
WO2009117698A2 (en) 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
CA2718092C (en) 2008-03-21 2019-03-19 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
EP3957754A1 (en) 2008-04-21 2022-02-23 Gen-Probe Incorporated Method for detecting chikungunya virus
US10359424B2 (en) 2008-05-28 2019-07-23 Fujifilm Wako Pure Chemical Corporation Primer and probe for detection of Mycobacterium intracellulare, and method for detection of Mycobacterium intracellulare using the primer or the probe
EP2151502A1 (en) 2008-07-30 2010-02-10 Lohmann Tierzucht GmbH Genetic variations associated with feather pecking behaviour in avians
US9127312B2 (en) 2011-02-09 2015-09-08 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
CA2679750A1 (en) 2008-09-23 2010-03-23 Nexus Dx, Inc. Methods for detecting nucleic acids in a sample
WO2010038042A1 (en) 2008-10-02 2010-04-08 Illumina Cambridge Ltd. Nucleic acid sample enrichment for sequencing applications
EP2210944A1 (en) 2009-01-22 2010-07-28 ATG:biosynthetics GmbH Methods for generation of RNA and (poly)peptide libraries and their use
CA2751888C (en) 2009-02-11 2022-06-14 Caris Mpi, Inc. Molecular profiling of tumors
EP3257859B1 (en) 2009-02-26 2020-09-23 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
CA2759611C (en) 2009-04-22 2018-11-13 Indiana University Research And Technology Corporation Compositions and methods for the treatment of chronic obstructive pulmonary disease and asthma
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
EP3450573B1 (en) 2009-06-23 2022-01-26 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
US8512955B2 (en) 2009-07-01 2013-08-20 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
US10072287B2 (en) 2009-09-10 2018-09-11 Centrillion Technology Holdings Corporation Methods of targeted sequencing
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
ES2848650T3 (es) 2009-09-14 2021-08-11 Sillajen Biotherapeutics Inc Terapia combinada contra el cáncer con virus vaccinia oncolítico
US8182994B2 (en) 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
WO2011036173A1 (en) 2009-09-24 2011-03-31 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
AU2010315400B2 (en) 2009-10-27 2016-07-21 Caris Mpi, Inc. Molecular profiling for personalized medicine
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Ｔｈｄ 프라이머 타겟 검출
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
JP6025255B2 (ja) 2009-12-10 2016-11-16 ターンストーン リミテッド パートナーシップ 腫瘍退縮性ラブドウイルス
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
BR112012018394B8 (pt) 2009-12-21 2021-07-27 Seegene Inc método para detecção de uma sequência de ácido nucleico alvo e kit para detecção de uma sequência de ácido nucleico alvo
EP2515899B1 (en) 2009-12-23 2016-05-25 ARCA biopharma, Inc. Methods and compositions for cardiovascular diseases and conditions
EP2529026B1 (en) 2010-01-25 2013-11-13 Rd Biosciences Inc. Self-folding amplification of target nucleic acid
WO2011094577A2 (en) 2010-01-29 2011-08-04 Micronics, Inc. Sample-to-answer microfluidic cartridge
WO2011103274A1 (en) 2010-02-17 2011-08-25 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
US9458513B2 (en) 2010-03-23 2016-10-04 Wako Pure Chemical Industries, Ltd. Primer and probe for detecting chlamydia trachomatis, and method for detecting chlamydia trachomatis using same
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
CN103079567A (zh) 2010-04-17 2013-05-01 拜尔健康护理有限责任公司 用于疾病和病症的治疗和预防的氟取代的ω-羧基芳基二苯脲的合成代谢产物
EP2561094B1 (en) 2010-04-21 2017-03-29 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
JP5454338B2 (ja) 2010-04-28 2014-03-26 株式会社島津製作所 液滴操作によるリアルタイム核酸増幅法
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 ＨＩＦ?２α 형질전환 마우스 및 이의 용도
EP3305920B1 (en) 2010-07-12 2020-02-12 Gen-Probe Incorporated Compositions and assays to detect seasonal h3 influenza a virus nucleic acid
CN103543282A (zh) 2010-07-23 2014-01-29 贝克曼考尔特公司 用于处理化验盒的系统
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
JP5904501B2 (ja) 2010-09-02 2016-04-13 国立研究開発法人理化学研究所 ２型糖尿病の検出方法
EP2625297B1 (en) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Compositions, methods and kits to detect adenovirus nucleic acids
ES2576927T3 (es) 2010-10-22 2016-07-12 T2 Biosystems, Inc. Sistemas de RMN y métodos para la detección rápida de analitos
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CN105772122B (zh) 2010-12-21 2017-11-03 株式会社岛津制作所 用于在管内操作对象成分的器件和方法
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
EP2661278B1 (en) 2011-01-04 2019-06-19 SillaJen Biotherapeutics, Inc. Tumor specific complement dependent cytotoxicity (cdc) antibodies generated by administration of oncolytic vaccinia virus, for use in the treatment of cancer
AU2012214643B2 (en) 2011-02-07 2016-12-15 Research Development Foundation Engineered immunoglobulin Fc polypeptides
RU2564122C2 (ru) 2011-02-24 2015-09-27 Хилл'С Пет Ньютришн, Инк. Способ и набор для диагностики гломерулонефрита у кошки
EP2681566A2 (en) 2011-02-28 2014-01-08 University of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
WO2012120377A2 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
EP3498864B1 (en) 2011-03-10 2024-10-09 Gen-Probe Incorporated Methods for the selection and optimization of oligonucleotide tag sequences
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
EP2694677A2 (en) 2011-04-04 2014-02-12 Netherland Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
WO2012138789A2 (en) 2011-04-04 2012-10-11 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
KR101291668B1 (ko) 2011-04-21 2013-08-01 서울대학교산학협력단 미코박테리아―대장균용 셔틀 벡터 및 이의 용도
WO2012149038A1 (en) 2011-04-25 2012-11-01 Advanced Bioscience Laboratories, Inc. Truncated hiv envelope proteins (env), methods and compositions related thereto
EP2702166B1 (en) 2011-04-25 2018-06-06 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
CA2872045A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
AU2012271528B2 (en) 2011-06-15 2015-06-25 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline
MX2013013627A (es) 2011-06-21 2014-04-25 Oncofactor Corp Composiciones y metodos para la terapia y diagnostico de cancer.
EP3564393A1 (en) 2011-06-21 2019-11-06 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
CA2841531C (en) 2011-07-15 2021-11-09 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
WO2013024175A2 (en) 2011-08-17 2013-02-21 Technische Universität München Diagnostic means and methods for type 2 diabetes
EP3255155B1 (en) 2011-09-08 2019-04-24 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
FR2981088B1 (fr) 2011-10-06 2013-11-29 Biomerieux Sa Arn polymerases mutees
WO2013064163A1 (en) 2011-11-01 2013-05-10 Academisch Medisch Centrum Methylation markers for colorectal cancer
ES2778054T3 (es) 2011-11-07 2020-08-07 Beckman Coulter Inc Sistema y método para transportar recipientes de muestras
EP2776845B1 (en) 2011-11-07 2020-11-04 Beckman Coulter, Inc. Robotic arm
JP6062449B2 (ja) 2011-11-07 2017-01-18 ベックマン コールター， インコーポレイテッド 標本コンテナ検出
JP2014532881A (ja) 2011-11-07 2014-12-08 ベックマン コールター， インコーポレイテッド 標本輸送システムのための磁気制動
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
KR20140092377A (ko) 2011-11-07 2014-07-23 베크만 컬터, 인코포레이티드 분취기 시스템 및 작업흐름
KR102035877B1 (ko) 2011-11-14 2019-10-23 알파시그마 에스.피.에이. 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
WO2013095935A1 (en) 2011-12-19 2013-06-27 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating hyperthyroidism in companion animals
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
JP5807542B2 (ja) 2011-12-22 2015-11-10 株式会社島津製作所 対象成分を操作するためのチップデバイス及びそれを用いた方法
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
EP2809783A2 (en) 2012-02-02 2014-12-10 Invenra, Inc. High throughput screen for biologically active polypeptides
WO2013126793A2 (en) 2012-02-24 2013-08-29 Gen-Probe Prodesse, Inc. Detection of shiga toxin genes in bacteria
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
ES2663234T3 (es) 2012-02-27 2018-04-11 Cellular Research, Inc Composiciones y kits para recuento molecular
WO2013129542A1 (ja) 2012-02-29 2013-09-06 独立行政法人理化学研究所 Ｈｌａ－ａ＊３１：０１アレルの検出方法
EP3461910B1 (en) 2012-04-19 2020-08-26 Life Technologies Corporation Nucleic acid amplification
CN114854832A (zh) 2012-04-19 2022-08-05 生命技术公司 核酸扩增
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
US9932628B2 (en) 2012-07-27 2018-04-03 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
AU2013202808B2 (en) 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
WO2014036369A1 (en) 2012-08-30 2014-03-06 Gen-Probe Incorporated Multiphase nucleic acid amplification
EP3257952B1 (en) 2012-09-11 2020-02-12 Life Technologies Corporation Nucleic acid amplification
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
WO2014055746A1 (en) 2012-10-04 2014-04-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and reagents for detection, quantitation, and serotyping of dengue viruses
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
EP2740805B1 (en) 2012-12-07 2019-02-20 SuppreMol GmbH Stratification and treatment of patients suffering from idiopathic thrombocytopenic purpura
KR102102123B1 (ko) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 유체 공학 회로 및 관련 제조 방법
EP3549674B1 (en) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Low elasticity films for microfluidic use
US20150346097A1 (en) 2012-12-21 2015-12-03 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
US20140213471A1 (en) 2013-01-24 2014-07-31 California Institute Of Technology Chromophore-based characterization and detection methods
CA2901501C (en) 2013-02-21 2023-03-07 Children's Hospital Of Eastern Ontario Research Institute Inc. Vaccine composition
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
EP2971090B1 (en) 2013-03-15 2020-05-06 Gen-Probe Incorporated Calibration method, apparatus and computer program product
US9255265B2 (en) 2013-03-15 2016-02-09 Illumina, Inc. Methods for producing stranded cDNA libraries
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
CN105392892A (zh) 2013-03-27 2016-03-09 六品科技公司 重组噬菌体和细菌检测方法
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
CN105189784B (zh) 2013-05-07 2020-06-30 珀金埃尔默健康科学有限公司 用于制备和分析核酸的装置
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CN105189750B (zh) 2013-05-07 2020-07-28 珀金埃尔默健康科学有限公司 使用粘土矿物和碱性溶液制备含核酸样品的方法
US20160186263A1 (en) 2013-05-09 2016-06-30 Trustees Of Boston University Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease
US9828625B2 (en) 2013-06-19 2017-11-28 Phage Diagnostics, Inc. Phage-based bacterial detection assay
US9547006B2 (en) 2013-08-08 2017-01-17 Institut Pasteur Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus
CN105452488B (zh) 2013-08-14 2020-07-14 简·探针公司 用于检测hev核酸的组合物和方法
SG10201806890VA (en) 2013-08-28 2018-09-27 Cellular Res Inc Massively parallel single cell analysis
MX2016004283A (es) 2013-10-03 2016-10-12 Oklahoma Med Res Found Biomarcadores para la actividad, e intesidad y arrebato de la enfermedad lupus eritematoso sistemico.
AU2014349828B2 (en) 2013-11-15 2021-01-28 Centre National De La Recherche Scientifique A molecular marker of Plasmodium falciparum artemisinin resistance
US20170009288A1 (en) 2014-02-03 2017-01-12 Thermo Fisher Scientific Baltics Uab Method for controlled dna fragmentation
US20170113221A1 (en) 2014-06-11 2017-04-27 Micronics, Inc. Microfluidic cartridges and apparatus with integrated assay controls for analysis of nucleic acids
GB201415349D0 (en) 2014-08-29 2014-10-15 Univ Leuven Kath Cofactor analogues for methyltransferases
EP3224362B1 (en) 2014-11-26 2024-09-25 The Regents of The University of California Therapeutic compositions comprising transcription factors and methods of making and using the same
EP3230314B1 (en) 2014-12-08 2023-05-03 Berg LLC Use of markers including filamin a in the diagnosis and treatment of prostate cancer
JP6944873B2 (ja) 2015-01-09 2021-10-06 ジェン−プローブ・インコーポレーテッド 細菌性膣症を診断するための方法および組成物
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 ｓｉＲＮＡ의 공동―운반용 나노복합체 및 이의 용도
WO2016118766A2 (en) 2015-01-21 2016-07-28 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of tick-borne pathogens
WO2016130516A1 (en) 2015-02-09 2016-08-18 Research Development Foundation Engineered immunoglobulin fc polypeptides displaying improved complement activation
EP3064592A1 (en) 2015-03-06 2016-09-07 Brigitte König Methods for the qualitative and quantitative detection of microbes in a sample
WO2016149357A1 (en) 2015-03-16 2016-09-22 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
EP3307908B1 (en) 2015-06-09 2019-09-11 Life Technologies Corporation Methods for molecular tagging
AU2016297510B2 (en) 2015-07-17 2021-09-09 President And Fellows Of Harvard College Methods of amplifying nucleic acid sequences
US10526408B2 (en) 2015-08-28 2020-01-07 Research Development Foundation Engineered antibody FC variants
AU2016341845B2 (en) 2015-10-18 2022-11-17 Affymetrix, Inc. Multiallelic genotyping of single nucleotide polymorphisms and indels
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
US20180363037A1 (en) 2015-12-09 2018-12-20 Life Technologies Corporation Detection and quantification of nucleic acid molecules associated with a surface
JP6894439B2 (ja) 2016-01-04 2021-06-30 ジェン−プローブ・インコーポレーテッド Ｃａｎｄｉｄａ種を検出するための方法及び組成物
EP3402880B1 (en) 2016-01-15 2024-01-03 Thermo Fisher Scientific Baltics UAB Thermophilic dna polymerase mutants
US20190032104A1 (en) 2016-01-21 2019-01-31 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
KR101845957B1 (ko) 2016-02-23 2018-04-05 전남대학교기술지주회사(주) 프로히비틴 유전자 타깃 백혈병 진단용 키트 및 이를 이용한 진단 방법
EP4151751A1 (en) 2016-04-14 2023-03-22 T2 Biosystems, Inc. Methods and systems for amplification in complex samples
US20200185063A1 (en) 2016-06-05 2020-06-11 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
AU2017278065B2 (en) 2016-06-10 2020-09-10 Gen-Probe Incorporated Compositions and methods for detecting Zika virus nucleic acid
CA3033016A1 (en) 2016-08-10 2018-02-15 Institut Pasteur Methods and reagents for detecting piperaquine-resistant plasmodium falciparum malaria
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
AU2017346854B2 (en) 2016-10-19 2024-05-23 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis C virus
US10508313B2 (en) 2016-11-21 2019-12-17 Gen-Probe Incorporated Compositions and methods for detecting or quantifying Hepatitis B virus
IL267372B2 (en) 2016-12-29 2024-02-01 Seegene Inc A method for reducing primer dimer formation and increasing amplification efficiency
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
WO2018140606A1 (en) 2017-01-26 2018-08-02 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
WO2018146162A1 (en) 2017-02-07 2018-08-16 Academisch Medisch Centrum Molecular biomarker for prognosis of sepsis patients
EP4219771A3 (en) 2017-03-24 2023-08-16 Gen-Probe Incorporated Compositions and methods for multiplex detection of viral pathogens in samples
EP4279613A3 (en) 2017-03-24 2024-05-22 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
WO2018223053A1 (en) 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
EP3631008A1 (en) 2017-06-02 2020-04-08 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
EP4276201A3 (en) 2017-06-07 2024-01-17 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
GB2578038B (en) 2017-06-16 2022-11-23 Life Technologies Corp Control nucleic acids, and compositions, kits, and uses thereof
US12140592B2 (en) 2017-06-16 2024-11-12 Oklahoma Medical Research Foundation Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis
EP3645710A1 (en) 2017-06-26 2020-05-06 Thermo Fisher Scientific Baltics Uab Thermophilic dna polymerase mutants
EP4286055B1 (en) 2017-07-10 2025-03-19 Gen-Probe Incorporated Method for determining the presence of multiple forms of a nucleic acid analyte in a sample
WO2019017680A2 (ko) 2017-07-19 2019-01-24 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miRNA 및 이를 이용한 진단키트
KR101956315B1 (ko) 2017-07-19 2019-03-08 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miR494 및 이를 이용한 진단키트
CN111094595A (zh) 2017-08-11 2020-05-01 简·探针公司 用于检测金黄色葡萄球菌的组合物和方法
EP3707278A1 (en) 2017-11-09 2020-09-16 Alnylam Pharmaceuticals Inc. Assays and methods for determining expression of the lect2 gene
JP7068451B2 (ja) 2017-11-17 2022-05-16 ジェン－プローブ・インコーポレーテッド Ｃ１ｏｒｆ４３核酸を検出するための組成物および方法
EP4502180A2 (en) 2018-01-29 2025-02-05 Gen-Probe Incorporated Analytical systems and methods
EP3749781B1 (en) 2018-02-06 2024-10-02 Gen-Probe Incorporated Far-red dye probe formulations
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
US20210317515A1 (en) 2018-07-10 2021-10-14 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
JP7469290B2 (ja) 2018-08-01 2024-04-16 ジェン－プローブ・インコーポレーテッド エプスタイン－バールウイルスの核酸を検出するための組成物および方法
CN109306376B (zh) * 2018-08-03 2022-06-24 国家卫生计生委科学技术研究所 检验核酸扩增均一性的质量控制标准品及其制备方法
WO2020033557A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3841224A1 (en) 2018-08-21 2021-06-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
AU2019324196A1 (en) 2018-08-24 2021-03-18 Gen-Probe Incorporated Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
WO2020053808A1 (en) 2018-09-12 2020-03-19 Georg Dewald Method of diagnosing vasoregulatory disorders
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
CN113195743A (zh) 2018-10-22 2021-07-30 简·探针公司 扩增，检测或定量人类多瘤病毒bk病毒的组合物和方法
EP4439066A2 (en) 2018-10-31 2024-10-02 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury
JP7462632B2 (ja) 2018-11-30 2024-04-05 カリス エムピーアイ インコーポレイテッド 次世代分子プロファイリング
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
WO2020142347A2 (en) 2018-12-31 2020-07-09 Gen-Probe Incorporated Systems and methods for filling multi-well cartridges with solid reagents
CN114051537A (zh) 2019-04-17 2022-02-15 艾基诺米公司 用于早期诊断子宫平滑肌瘤和平滑肌肉瘤的改进方法
EP3963099A1 (en) 2019-04-30 2022-03-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
CN118083476A (zh) 2019-05-03 2024-05-28 简·探针公司 用于分析系统的容器输送系统
CA3138015A1 (en) 2019-06-14 2020-12-17 Jong Yoon Chun Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
EP3994284A1 (en) 2019-07-03 2022-05-11 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
CA3152309A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
WO2021046270A1 (en) 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
WO2021119124A1 (en) 2019-12-09 2021-06-17 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
US20230117369A1 (en) 2020-03-04 2023-04-20 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleaic acid
EP4146821A1 (en) 2020-05-07 2023-03-15 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
KR20230007464A (ko) 2020-06-05 2023-01-12 주식회사 씨젠 호흡기 병원체 검출을 위한 검체수송 키트 및 이를 이용한 호흡기 병원체 검출방법
WO2022006286A1 (en) 2020-06-30 2022-01-06 Lunglife Ai Methods for detecting lung cancer
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US20230393163A1 (en) 2020-10-21 2023-12-07 Gen-Probe Incorporated Fluid container management system
CN118661103A (zh) 2021-04-06 2024-09-17 布普格生物制药公司 雌激素受体(er)阳性样和雌激素受体(er)阴性样乳腺癌的蛋白质标志物
CA3214833A1 (en) 2021-04-06 2022-10-13 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
CA3214819A1 (en) 2021-04-06 2022-10-13 Guisong WANG Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
US20240230699A1 (en) 2021-07-21 2024-07-11 Seegene. Inc. Assembled analysis system, method, and computer readable recording medium
EP4382620A3 (en) 2021-07-27 2024-08-07 Gen-Probe Incorporated Compositions and methods for detecting c. jejuni and at least one of salmonella, c. coli, shigella, and stec
EP4411386A1 (en) 2021-09-30 2024-08-07 Seegene, Inc. Method for processing and analyzing sample in molecular diagnostic system
EP4424242A1 (en) 2021-10-29 2024-09-04 Seegene, Inc. Sample collecting swab tool and method for detection of respiratory pathogen
IL316114A (en) 2022-04-06 2024-12-01 Larimar Therapeutics Inc Parataxin-sensitive markers for monitoring an alternative drug of Parataxin
EP4282980A1 (en) 2022-05-23 2023-11-29 Mobidiag Oy Methods for amplifying a nucleic acid
WO2023230531A1 (en) 2022-05-24 2023-11-30 Lunglife Ai, Inc. Methods for detecting circulating genetically abnormal cells
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
KR20250023497A (ko) 2022-06-10 2025-02-18 리서치 디벨럽먼트 파운데이션 조작된 fcriib 선택적 igg1 fc 변이체 및 이의 용도
KR102559124B1 (ko) 2022-08-25 2023-07-26 주식회사 엔젠바이오 Flt3 유전자 증폭용 조성물 및 이의 용도
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024161179A1 (en) 2023-01-31 2024-08-08 Mobidiag Oy Compositions and methods for detecting stx nucleic acids
EP4454758A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls
EP4455304A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls
EP4455303A1 (en) 2023-04-28 2024-10-30 Mobidiag Oy Nucleic acid amplification process controls

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128042A3 (en) 1983-06-06 1985-01-16 Genentech, Inc. A process for indentifying or isolating a dna sequence, and a dna hybridization probe therefor
CA1288073C (en) 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DK171161B1 (da) 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
FI76119C (fi) 1986-02-27 1988-09-09 Orion Yhtymae Oy Kvantitativ bestaemning av nukleinsyramolekyler och reagensfoerpackning som anvaends vid foerfarandet.

Also Published As

Publication number Publication date
HU216317B (hu) 1999-06-28
JPH02500565A (ja) 1990-03-01
WO1988010315A1 (en) 1988-12-29
DE3852177T2 (de) 1995-04-06
FI896077A0 (fi) 1989-12-19
DE3856428D1 (de) 2000-11-02
ES2009286A6 (es) 1989-09-16
IE950293L (en) 1988-12-19
JP2843586B2 (ja) 1999-01-06
IL86724A (en) 1995-01-24
NZ225077A (en) 1991-06-25
EP0368906A1 (en) 1990-05-23
GR880100396A (el) 1989-03-08
DE3852177D1 (de) 1995-01-05
KR960014107B1 (ko) 1996-10-14
KR890701741A (ko) 1989-12-21
EP0623683B1 (en) 2000-09-27
PT87769B (pt) 1992-10-30
HUT52823A (en) 1990-08-28
FI93743B (fi) 1995-02-15
EP0368906B2 (en) 1999-08-04
EP0368906B1 (en) 1994-11-23
NO895090D0 (no) 1989-12-18
DE3856428T2 (de) 2001-04-19
DK644489A (da) 1990-02-19
IE65089B1 (en) 1995-10-04
ATE196657T1 (de) 2000-10-15
DK644489D0 (da) 1989-12-19
DK175614B1 (da) 2004-12-27
NO895090L (no) 1990-02-19
DE3852177T3 (de) 2000-06-15
IE881848L (en) 1988-12-19
NO303068B1 (no) 1998-05-25
IL86724A0 (en) 1988-11-30
BR8807097A (pt) 1989-10-17
FI93743C (fi) 1995-05-26
ATE114335T1 (de) 1994-12-15
EP0623683A1 (en) 1994-11-09

Similar Documents

Publication Publication Date Title
PT87769A (pt) Transcripton-based nucleic acid amplification detection systems
US4683202B1 (pt)
DK110691D0 (da) Selv-vedligeholdende sekvensreplikationssystem

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920414

PC3A Transfer or assignment

Free format text: 19990422 AKZO NOBEL N.V. NL

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080617