[go: up one dir, main page]

PT3710437T - Separação enantiomérica de nicotina racémica por adição de um enantiómero de ácido tartárico o,o'-disubstituído de baixa pureza ótica - Google Patents

Separação enantiomérica de nicotina racémica por adição de um enantiómero de ácido tartárico o,o'-disubstituído de baixa pureza ótica

Info

Publication number
PT3710437T
PT3710437T PT188161129T PT18816112T PT3710437T PT 3710437 T PT3710437 T PT 3710437T PT 188161129 T PT188161129 T PT 188161129T PT 18816112 T PT18816112 T PT 18816112T PT 3710437 T PT3710437 T PT 3710437T
Authority
PT
Portugal
Prior art keywords
addition
tartaric acid
enantiomeric separation
acid enantiomer
racemic nicotine
Prior art date
Application number
PT188161129T
Other languages
English (en)
Original Assignee
Siegfried Ag
Contraf Nicotex Tobacco Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siegfried Ag, Contraf Nicotex Tobacco Gmbh filed Critical Siegfried Ag
Publication of PT3710437T publication Critical patent/PT3710437T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Addiction (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT188161129T 2017-12-22 2018-12-18 Separação enantiomérica de nicotina racémica por adição de um enantiómero de ácido tartárico o,o'-disubstituído de baixa pureza ótica PT3710437T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17210181 2017-12-22

Publications (1)

Publication Number Publication Date
PT3710437T true PT3710437T (pt) 2023-03-17

Family

ID=60782088

Family Applications (1)

Application Number Title Priority Date Filing Date
PT188161129T PT3710437T (pt) 2017-12-22 2018-12-18 Separação enantiomérica de nicotina racémica por adição de um enantiómero de ácido tartárico o,o'-disubstituído de baixa pureza ótica

Country Status (28)

Country Link
US (1) US11279685B2 (pt)
EP (1) EP3710437B1 (pt)
JP (1) JP7030208B2 (pt)
KR (1) KR20200103730A (pt)
CN (1) CN111527077B (pt)
AU (1) AU2018391657B2 (pt)
BR (1) BR112020012458A2 (pt)
CA (1) CA3085208C (pt)
CL (1) CL2020001656A1 (pt)
CY (1) CY1125900T1 (pt)
DK (1) DK3710437T3 (pt)
ES (1) ES2940319T3 (pt)
FI (1) FI3710437T3 (pt)
HR (1) HRP20230119T1 (pt)
HU (1) HUE061702T2 (pt)
IL (1) IL275585B2 (pt)
LT (1) LT3710437T (pt)
MY (1) MY193072A (pt)
NZ (1) NZ765535A (pt)
PE (1) PE20211392A1 (pt)
PL (1) PL3710437T3 (pt)
PT (1) PT3710437T (pt)
RS (1) RS64017B1 (pt)
RU (1) RU2753492C1 (pt)
SG (1) SG11202005641XA (pt)
SI (1) SI3710437T1 (pt)
WO (1) WO2019121649A1 (pt)
ZA (1) ZA202003683B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3728215T (lt) 2017-12-22 2021-12-10 Siegfried Ag Raceminio nikotino gavimo etilnikotinato reakcijoje su n-vinilpirolidonu, dalyvaujant natrio etanoliatui arba kalio etanoliatui, arba jų mišiniams, būdas, vykdant sintezę viename inde
LU101511B1 (en) * 2019-12-02 2021-06-04 Herrera Arturo Solis (S)-3-[1-Methylpyrrolidin-2-yl]pyridine, analogues thereof, precursors thereof, or its derivatives, for the use as a pharmaceutical in form of a parenteral administration and a process for the preparation of an injectable substance
CN111187250B (zh) * 2020-01-08 2023-04-07 深圳黑尔格科技有限公司 一种拆分式制备光学活性尼古丁的方法
CN114644614B (zh) * 2021-04-21 2023-03-28 黄冈中有生物科技有限公司 一种左旋烟碱的制备方法
CN115260088A (zh) * 2021-04-30 2022-11-01 武汉中有药业有限公司 烟碱及其中间体的制备方法
CN113416180A (zh) * 2021-08-09 2021-09-21 东莞市鸿馥生物科技有限公司 一种(s)-1-甲基-2-(3-吡啶基)吡咯烷的拆分方法
CN114249711A (zh) * 2022-03-02 2022-03-29 北京邦克凯姆医药科技有限公司 一种拆分制备尼古丁的方法
CN114671852A (zh) * 2022-04-24 2022-06-28 仙居两山生物科技有限公司 一种高纯度左旋烟碱医药中间体的制备方法
CN115093394B (zh) * 2022-07-20 2024-10-18 北京世桥生物制药有限公司 S-(-)-尼古丁(-)-二苯甲酰-l-酒石酸盐晶型、制备方法及应用
CN115286615A (zh) * 2022-09-01 2022-11-04 深圳市真味生物科技有限公司 一种消旋尼古丁的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003342259A (ja) 2001-12-21 2003-12-03 Toray Ind Inc 光学活性シスピペリジン誘導体の製造法
JP2006335639A (ja) 2003-01-23 2006-12-14 Nagase & Co Ltd 光学活性なフルルビプロフェンの製造方法
CN102617547B (zh) 2011-01-27 2016-02-10 上海特化医药科技有限公司 一种制备消旋尼古丁的方法
US8378111B2 (en) * 2011-02-02 2013-02-19 Divi's Laboratories, Ltd. Process for the resolution of (R,S)-nicotine
US8367837B2 (en) 2011-02-14 2013-02-05 Divi's Laboratories, Ltd. Process for the preparation of (R,S)-nicotine
WO2016065209A2 (en) 2014-10-22 2016-04-28 Next Generation Labs, LLC Process for the preparation of (r,s)-nicotine
US9809567B2 (en) * 2014-12-09 2017-11-07 Njoy, Llc Synthesis and resolution of nicotine
WO2017117575A1 (en) 2015-12-30 2017-07-06 Next Generation Labs, LLC Nicotine replacement therapy products comprising synthetic nicotine
WO2017119003A1 (en) 2016-01-08 2017-07-13 Council Of Scientific & Industrial Research A process for the preparation of nicotine
LT3728215T (lt) 2017-12-22 2021-12-10 Siegfried Ag Raceminio nikotino gavimo etilnikotinato reakcijoje su n-vinilpirolidonu, dalyvaujant natrio etanoliatui arba kalio etanoliatui, arba jų mišiniams, būdas, vykdant sintezę viename inde

Also Published As

Publication number Publication date
NZ765535A (en) 2024-03-22
DK3710437T3 (da) 2023-02-20
RS64017B1 (sr) 2023-03-31
SI3710437T1 (sl) 2023-04-28
HRP20230119T1 (hr) 2023-03-31
CN111527077A (zh) 2020-08-11
LT3710437T (lt) 2023-04-25
WO2019121649A1 (en) 2019-06-27
JP2021515029A (ja) 2021-06-17
CA3085208A1 (en) 2019-06-27
US20200331883A1 (en) 2020-10-22
FI3710437T3 (fi) 2023-03-23
CL2020001656A1 (es) 2020-11-13
IL275585B2 (en) 2023-09-01
EP3710437A1 (en) 2020-09-23
BR112020012458A2 (pt) 2020-11-24
KR20200103730A (ko) 2020-09-02
PE20211392A1 (es) 2021-07-27
CY1125900T1 (el) 2024-09-20
AU2018391657A1 (en) 2020-07-09
CA3085208C (en) 2023-05-23
ZA202003683B (en) 2023-01-25
AU2018391657B2 (en) 2022-03-10
EP3710437B1 (en) 2022-12-14
SG11202005641XA (en) 2020-07-29
US11279685B2 (en) 2022-03-22
MY193072A (en) 2022-09-26
ES2940319T3 (es) 2023-05-05
IL275585B1 (en) 2023-05-01
HUE061702T2 (hu) 2023-08-28
IL275585A (en) 2020-08-31
PL3710437T3 (pl) 2023-04-11
RU2753492C1 (ru) 2021-08-17
CN111527077B (zh) 2023-03-10
JP7030208B2 (ja) 2022-03-04

Similar Documents

Publication Publication Date Title
IL275585A (en) A process for separating enantiomers of nicotine from a serial mixture
EP3237389A4 (en) 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one as a seed treatment
MY181938A (en) (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
WO2016079751A3 (en) A process for preparation of vortioxetine and polymorphs thereof
EP3498836A4 (en) MANUFACTURING PROCESS FOR L-AMINO ACID
WO2014192030A3 (en) An improved process for preparation of dabigatran etexilate and pharmaceutically acceptable acid addition salts thereof
NZ722412A (en) Methods of preparing a hydrochloride salt of (1r,2r,5r)-5-amino-2-methylcyclohexanol
IN2013CH05455A (pt)
EP3177296A4 (en) Enantiomers of the 1',6'-isomer of neplanocin a
ZA201708769B (en) Separation of enantiomers of 3-ethylbicyclo[3.2.0]hept-3-en-6-one
PH12016501326A1 (en) (s)-3'-methyl-abscisic acid and esters thereof
PH12017501869A1 (en) (s)-2'-vinyl-abscisic acid derivatives
DK3356329T3 (da) Fremgangsmåde til fremstilling af 1-(4-methansulfonyl-2-trifluormethylbenzyl)-2-methyl-1H-pyrrolo[2,3-B]pyridin-3-yleddikesyre
WO2014184756A3 (en) Process for preparation of arformoterol of salt thereof
GB201705485D0 (en) Drugs intermediates m-aminobenzoic acid synthesis method
WO2015104602A3 (en) A process for the preparation of anagliptin and its intermediates thereof
WO2016007587A3 (en) 3'-substituted-abscisic acid derivatives
NZ758433A (en) Process for the preparation of pirlindole enantiomers and its salts
PL3592734T3 (pl) Sól aminowa kwasu (1r,3s)-3-(5-cyano-4-fenylo-1,3-tiazol- 2-ilokarbamoilo)cyklopentanokarboksylowego
GB201708117D0 (en) Drug intermediates isovaleric acid synthesis method
GB201719123D0 (en) 2,3-dihydroxy-succinic acid drug intermediates synthesis method
GB201714450D0 (en) 4,6-dihydroxyquinoline-5,8-diquinone-2-formic acid drug intermediates synthesis method
EP3725312A4 (en) NEW CHEMICAL COMPOUND CONTAINING THE ACTIVE ENANTIOMER S - (-) KETOROLAC TROMETHAMINE FOR THE TREATMENT OF PAIN
GB201708120D0 (en) Drugs intermediates 3,4-dimethoxy-6-nitrobenzoic acid synthesis method
GB201719127D0 (en) Methylchloroperoxybenzoic acid drug intermediates synthesis method