PT3266791T - Nucleótidos etiquetados - Google Patents

Nucleótidos etiquetados

Info

Publication number: PT3266791T
Authority: PT; Portugal
Prior art keywords: labelled nucleotides; labelled; nucleotides
Prior art date: 2001-12-04

Application number

PT171776503T

Other languages

English (en)

Original Assignee

Illumina Cambridge Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-04

Filing date

2002-12-04

Publication date

2021-03-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26246831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3266791(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-12-04 Priority claimed from GBGB0129012.1A external-priority patent/GB0129012D0/en

2002-12-04 Application filed by Illumina Cambridge Ltd filed Critical Illumina Cambridge Ltd

2021-03-03 Publication of PT3266791T publication Critical patent/PT3266791T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/186—Modifications characterised by incorporating a non-extendable or blocking moiety
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/113—Cycle sequencing

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Plant Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

PT171776503T 2001-12-04 2002-12-04 Nucleótidos etiquetados PT3266791T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0129012.1A GB0129012D0 (en)	2001-12-04	2001-12-04	Labelled nucleotides
US10/227,131 US7057026B2 (en)	2001-12-04	2002-08-23	Labelled nucleotides

Publications (1)

Publication Number	Publication Date
PT3266791T true PT3266791T (pt)	2021-03-03

Family

ID=26246831

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT171776503T PT3266791T (pt)	2001-12-04	2002-12-04	Nucleótidos etiquetados
PT2781434T PT1451351T (pt)	2001-12-04	2002-12-04	Nucleótidos etiquetados

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PT2781434T PT1451351T (pt)	2001-12-04	2002-12-04	Nucleótidos etiquetados

Country Status (17)

Country	Link
US (4)	US7057026B2 (pt)
EP (4)	EP3266791B1 (pt)
JP (1)	JP2005511058A (pt)
KR (1)	KR20050044668A (pt)
CN (1)	CN1617937A (pt)
AU (1)	AU2002349155A1 (pt)
BR (1)	BR0214683A (pt)
CA (1)	CA2469066A1 (pt)
CY (2)	CY1118765T1 (pt)
DK (2)	DK3266791T3 (pt)
ES (2)	ES2858359T3 (pt)
HK (1)	HK1248710A1 (pt)
IL (1)	IL162170A0 (pt)
IS (1)	IS7291A (pt)
PT (2)	PT3266791T (pt)
SI (1)	SI3266791T1 (pt)
WO (1)	WO2003048387A2 (pt)

Families Citing this family (877)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7875440B2 (en)	1998-05-01	2011-01-25	Arizona Board Of Regents	Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en)	1998-05-01	2004-08-24	Arizona Board Of Regents	Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6818395B1 (en)	1999-06-28	2004-11-16	California Institute Of Technology	Methods and apparatus for analyzing polynucleotide sequences
US9708358B2 (en)	2000-10-06	2017-07-18	The Trustees Of Columbia University In The City Of New York	Massive parallel method for decoding DNA and RNA
ATE356222T1 (de)	2000-10-06	2007-03-15	Univ Columbia	Massives parallelverfahren zur dekodierung von dna und rna
US7297518B2 (en)	2001-03-12	2007-11-20	California Institute Of Technology	Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
GB0129012D0 (en) *	2001-12-04	2002-01-23	Solexa Ltd	Labelled nucleotides
US7057026B2 (en) *	2001-12-04	2006-06-06	Solexa Limited	Labelled nucleotides
US20030215816A1 (en) *	2002-05-20	2003-11-20	Narayan Sundararajan	Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
US11008359B2 (en)	2002-08-23	2021-05-18	Illumina Cambridge Limited	Labelled nucleotides
DK1560838T3 (da)	2002-08-23	2009-09-07	Illumina Cambridge Ltd	M rkede nuklotider
US7414116B2 (en)	2002-08-23	2008-08-19	Illumina Cambridge Limited	Labelled nucleotides
DK3363809T3 (da) *	2002-08-23	2020-05-04	Illumina Cambridge Ltd	Modificerede nukleotider til polynukleotidsekvensering
US20050032081A1 (en) *	2002-12-13	2005-02-10	Jingyue Ju	Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
GB0307403D0 (en)	2003-03-31	2003-05-07	Medical Res Council	Selection by compartmentalised screening
US20060078893A1 (en)	2004-10-12	2006-04-13	Medical Research Council	Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en)	2003-03-31	2003-05-07	Medical Res Council	Compartmentalised combinatorial chemistry
US7572581B2 (en)	2003-06-30	2009-08-11	Roche Molecular Systems, Inc.	2′-terminator nucleotide-related methods and systems
WO2005044836A2 (de)	2003-11-05	2005-05-19	Genovoxx Gmbh	Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US7169560B2 (en)	2003-11-12	2007-01-30	Helicos Biosciences Corporation	Short cycle methods for sequencing polynucleotides
EP2248911A1 (en)	2004-02-19	2010-11-10	Helicos Biosciences Corporation	Methods and kits for analyzing polynucleotide sequences
CA2557818A1 (en) *	2004-03-03	2005-09-15	The Trustees Of Columbia University In The City Of New York	Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry
US20050221339A1 (en)	2004-03-31	2005-10-06	Medical Research Council Harvard University	Compartmentalised screening by microfluidic control
WO2006073436A2 (en) *	2004-04-29	2006-07-13	The Trustees Of Columbia University In The City Of New York	Mass tag pcr for multiplex diagnostics
US7476734B2 (en) *	2005-12-06	2009-01-13	Helicos Biosciences Corporation	Nucleotide analogs
US7635562B2 (en)	2004-05-25	2009-12-22	Helicos Biosciences Corporation	Methods and devices for nucleic acid sequence determination
US7968287B2 (en)	2004-10-08	2011-06-28	Medical Research Council Harvard University	In vitro evolution in microfluidic systems
GB0427236D0 (en)	2004-12-13	2005-01-12	Solexa Ltd	Improved method of nucleotide detection
WO2006064199A1 (en) *	2004-12-13	2006-06-22	Solexa Limited	Improved method of nucleotide detection
US7220549B2 (en)	2004-12-30	2007-05-22	Helicos Biosciences Corporation	Stabilizing a nucleic acid for nucleic acid sequencing
EP1879906A4 (en) *	2005-01-05	2009-07-22	Advanced Genetic Analysis Corp	REVERSIBLE NUCLEOTIDE TERMINATORS AND USES THEREOF
US7482120B2 (en)	2005-01-28	2009-01-27	Helicos Biosciences Corporation	Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
EP2236628A3 (en)	2005-02-01	2010-10-13	AB Advanced Genetic Analysis Corporation	Reagents, methods and libraries for bead-based sequencing
EP2316977A1 (en)	2005-02-01	2011-05-04	AB Advanced Genetic Analysis Corporation	Reagents, methods and libraries for bead-based amflication
GB0507835D0 (en) *	2005-04-18	2005-05-25	Solexa Ltd	Method and device for nucleic acid sequencing using a planar wave guide
GB0509508D0 (en) *	2005-05-10	2005-06-15	Solexa Ltd	Improved polymerases
WO2006120433A1 (en)	2005-05-10	2006-11-16	Solexa Limited	Improved polymerases
US20060281100A1 (en) *	2005-06-14	2006-12-14	Shen Gene G	Thiotriphosphate nucleotide dye terminators
WO2007002204A2 (en)	2005-06-21	2007-01-04	The Trustees Of Columbia University In The City Of New York	Pyrosequencing methods and related compostions
GB0517097D0 (en)	2005-08-19	2005-09-28	Solexa Ltd	Modified nucleosides and nucleotides and uses thereof
US7666593B2 (en)	2005-08-26	2010-02-23	Helicos Biosciences Corporation	Single molecule sequencing of captured nucleic acids
US7982029B2 (en)	2005-10-31	2011-07-19	The Trustees Of Columbia University In The City Of New York	Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods
US8796432B2 (en)	2005-10-31	2014-08-05	The Trustees Of Columbia University In The City Of New York	Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods
US20090088332A1 (en) *	2005-11-21	2009-04-02	Jingyue Ju	Multiplex Digital Immuno-Sensing Using a Library of Photocleavable Mass Tags
WO2007081387A1 (en)	2006-01-11	2007-07-19	Raindance Technologies, Inc.	Microfluidic devices, methods of use, and kits for performing diagnostics
BRPI0707348A2 (pt) *	2006-01-19	2011-05-03	Univ New York State Res Found	métodos e dispositivos para detecção e identificação de moléculas biológicas e microesferas codificadas
US7397546B2 (en)	2006-03-08	2008-07-08	Helicos Biosciences Corporation	Systems and methods for reducing detected intensity non-uniformity in a laser beam
WO2007123744A2 (en) *	2006-03-31	2007-11-01	Solexa, Inc.	Systems and devices for sequence by synthesis analysis
ES2829295T3 (es)	2006-04-04	2021-05-31	Keygene Nv	Detección de alto rendimiento de marcadores moleculares basados en AFLP y secuenciación de alto rendimiento
WO2007121489A2 (en) *	2006-04-19	2007-10-25	Applera Corporation	Reagents, methods, and libraries for gel-free bead-based sequencing
WO2008063227A2 (en)	2006-05-11	2008-05-29	Raindance Technologies, Inc.	Microfluidic devices
US9562837B2 (en)	2006-05-11	2017-02-07	Raindance Technologies, Inc.	Systems for handling microfludic droplets
EP2021415B1 (en)	2006-05-18	2017-03-15	Illumina Cambridge Limited	Dye compounds and the use of their labelled conjugates
US8889348B2 (en) *	2006-06-07	2014-11-18	The Trustees Of Columbia University In The City Of New York	DNA sequencing by nanopore using modified nucleotides
JP2009542220A (ja) *	2006-06-30	2009-12-03	アプライドバイオシステムズ，エルエルシー	可逆性ターミネーターヌクレオチドおよび使用方法
EP2182079B1 (en)	2006-07-12	2014-09-10	Keygene N.V.	High throughput physical mapping using AFLP
EP2077912B1 (en)	2006-08-07	2019-03-27	The President and Fellows of Harvard College	Fluorocarbon emulsion stabilizing surfactants
AU2007284651B2 (en)	2006-08-09	2014-03-20	Institute For Systems Biology	Organ-specific proteins and methods of their use
US8053191B2 (en)	2006-08-31	2011-11-08	Westend Asset Clearinghouse Company, Llc	Iterative nucleic acid assembly using activation of vector-encoded traits
US8399188B2 (en)	2006-09-28	2013-03-19	Illumina, Inc.	Compositions and methods for nucleotide sequencing
WO2008045158A1 (en)	2006-10-10	2008-04-17	Illumina, Inc.	Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization
US20080242560A1 (en) *	2006-11-21	2008-10-02	Gunderson Kevin L	Methods for generating amplified nucleic acid arrays
WO2008069973A2 (en)	2006-12-01	2008-06-12	The Trustees Of Columbia University In The City Of New York	Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
KR101504640B1 (ko) *	2006-12-05	2015-03-20	레이저젠, 인코퍼레이티드	광절단가능 표지된 뉴클레오티드와 뉴클레오시드, 표지된 뉴클레오티드와 뉴클레오시드, 그리고 ｄｎａ 염기서열분석에서 이들의 이용 방법
US7897737B2 (en)	2006-12-05	2011-03-01	Lasergen, Inc.	3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
EP2121983A2 (en)	2007-02-02	2009-11-25	Illumina Cambridge Limited	Methods for indexing samples and sequencing multiple nucleotide templates
US8612161B2 (en)	2008-03-19	2013-12-17	Intelligent Biosystems Inc.	Methods and compositions for base calling nucleic acids
US11035823B2 (en)	2009-03-17	2021-06-15	Qiagen Sciences, Llc	Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en)	2007-02-05	2013-07-09	Intelligent Bio-Systems, Inc.	Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en)	2007-02-05	2024-03-26	IsoPlexis Corporation	Methods and devices for sequencing nucleic acids in smaller batches
US8772046B2 (en)	2007-02-06	2014-07-08	Brandeis University	Manipulation of fluids and reactions in microfluidic systems
CN101631796B (zh) *	2007-03-09	2013-08-07	独立行政法人理化学研究所	具有由单核苷或单核苷酸衍生的结构的化合物、核酸、标记物以及核酸检测方法和试剂盒
JP5750209B2 (ja)	2007-03-16	2015-07-15	アプタバイオサイエンスリミテッド	機能性分子、機能性分子合成用アミダイド、及び標的物質解析方法
US8592221B2 (en)	2007-04-19	2013-11-26	Brandeis University	Manipulation of fluids, fluid components and reactions in microfluidic systems
US7678894B2 (en) *	2007-05-18	2010-03-16	Helicos Biosciences Corporation	Nucleotide analogs
EP2181204A2 (en) *	2007-08-23	2010-05-05	Applied Biosystems Inc.	Methods of modifying support surfaces for the immobilization of particles and the use of the immobilized particles for analyzing nucleic acids
JP2010537643A (ja) *	2007-08-29	2010-12-09	アプライドバイオシステムズ，エルエルシー	代替的な核酸配列決定法
EP2940029B1 (en)	2007-10-19	2023-11-29	The Trustees of Columbia University in the City of New York	Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
EP3431615A3 (en) *	2007-10-19	2019-02-20	The Trustees of Columbia University in the City of New York	Dna sequencing with non-fluorescent nucleotide reversible terminators cleavable label modified nucleotide terminators
US7811810B2 (en)	2007-10-25	2010-10-12	Industrial Technology Research Institute	Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7767441B2 (en) *	2007-10-25	2010-08-03	Industrial Technology Research Institute	Bioassay system including optical detection apparatuses, and method for detecting biomolecules
WO2009067628A1 (en) *	2007-11-20	2009-05-28	Applied Biosystems Inc.	Reversible di-nucleotide terminator sequencing
US8652781B2 (en)	2008-02-12	2014-02-18	Pacific Biosciences Of California, Inc.	Cognate sampling kinetics
CN102027136A (zh)	2008-03-17	2011-04-20	表现研究有限公司	发现表达连接基因
US9017973B2 (en) *	2008-03-19	2015-04-28	Intelligent Biosystems, Inc.	Methods and compositions for incorporating nucleotides
EP2274446B1 (en) *	2008-03-31	2015-09-09	Pacific Biosciences of California, Inc.	Two slow-step polymerase enzyme systems and methods
US8420366B2 (en) *	2008-03-31	2013-04-16	Pacific Biosciences Of California, Inc.	Generation of modified polymerases for improved accuracy in single molecule sequencing
WO2009145820A2 (en) *	2008-03-31	2009-12-03	Pacific Biosciences Of California, Inc.	Generation of modified polymerases for improved accuracy in single molecule sequencing
US8999676B2 (en)	2008-03-31	2015-04-07	Pacific Biosciences Of California, Inc.	Recombinant polymerases for improved single molecule sequencing
US8039817B2 (en)	2008-05-05	2011-10-18	Illumina, Inc.	Compensator for multiple surface imaging
EP2294214A2 (en) *	2008-05-07	2011-03-16	Illumina, Inc.	Compositions and methods for providing substances to and from an array
EP2307565B1 (en)	2008-06-11	2017-11-29	Lasergen, Inc.	Reversible nucleosides and nucleotides terminators and their use in dna sequencing
WO2010003132A1 (en)	2008-07-02	2010-01-07	Illumina Cambridge Ltd.	Using populations of beads for the fabrication of arrays on surfaces
US20100120034A1 (en) *	2008-07-03	2010-05-13	Life Technologies Corporation	Methylation analysis of mate pairs
US12038438B2 (en)	2008-07-18	2024-07-16	Bio-Rad Laboratories, Inc.	Enzyme quantification
EP2315629B1 (en)	2008-07-18	2021-12-15	Bio-Rad Laboratories, Inc.	Droplet libraries
US8173198B2 (en) *	2008-07-23	2012-05-08	Life Technologies Corporation	Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
US10759824B2 (en)	2008-09-03	2020-09-01	Quantumdx Group Limited	Design, synthesis and use of synthetic nucleotides comprising charge mass tags
WO2010026490A1 (en) *	2008-09-03	2010-03-11	Quantumdx Group Limited	Design, synthesis and use of synthetic nucleotides comprising charge mass tags
ES2594873T3 (es) *	2008-09-03	2016-12-23	Quantumdx Group Limited	Métodos y kits para la secuenciación de ácido nucleico
WO2017120148A1 (en)	2016-01-04	2017-07-13	Quantumdx Group Limited	Design, synthesis and use of synthetic nucleotides comprising charge mass tags
AU2009288696A1 (en) *	2008-09-05	2010-03-11	Pacific Biosciences Of California, Inc.	Sequencing by cognate sampling
US8383345B2 (en)	2008-09-12	2013-02-26	University Of Washington	Sequence tag directed subassembly of short sequencing reads into long sequencing reads
WO2010038042A1 (en)	2008-10-02	2010-04-08	Illumina Cambridge Ltd.	Nucleic acid sample enrichment for sequencing applications
US8541207B2 (en)	2008-10-22	2013-09-24	Illumina, Inc.	Preservation of information related to genomic DNA methylation
US8486865B2 (en) *	2008-11-03	2013-07-16	The Regents Of The University Of California	Methods for detecting modification resistant nucleic acids
WO2010059206A2 (en)	2008-11-19	2010-05-27	Pacific Biosciences Of California, Inc.	Modular nucleotide compositions and uses therefor
WO2010068702A2 (en) *	2008-12-10	2010-06-17	Illumina, Inc.	Methods and compositions for hybridizing nucleic acids
EP2607496B1 (en)	2008-12-23	2014-07-16	Illumina, Inc.	Methods useful in nucleic acid sequencing protocols
WO2010082815A1 (en)	2009-01-13	2010-07-22	Keygene N.V.	Novel genome sequencing strategies
EP3415235A1 (en)	2009-03-23	2018-12-19	Raindance Technologies Inc.	Manipulation of microfluidic droplets
US20100255487A1 (en)	2009-03-27	2010-10-07	Life Technologies Corporation	Methods and apparatus for single molecule sequencing using energy transfer detection
GB0907372D0 (en)	2009-04-29	2009-06-10	Invitrogen Dynal As	Particles
US12129514B2 (en)	2009-04-30	2024-10-29	Molecular Loop Biosolutions, Llc	Methods and compositions for evaluating genetic markers
JP2012525147A (ja)	2009-04-30	2012-10-22	グッドスタートジェネティクス，インコーポレイテッド	遺伝マーカーを評価するための方法および組成物
EP2427572B1 (en) *	2009-05-01	2013-08-28	Illumina, Inc.	Sequencing methods
US20100311144A1 (en)	2009-06-05	2010-12-09	Life Technologies Corporation	Mutant dna polymerases
US10036063B2 (en)	2009-07-24	2018-07-31	Illumina, Inc.	Method for sequencing a polynucleotide template
LT2669387T (lt)	2009-08-25	2016-10-25	Illumina, Inc.	Polinukleotidų atrankos ir padauginimo būdai
US10520500B2 (en)	2009-10-09	2019-12-31	Abdeslam El Harrak	Labelled silica-based nanomaterial with enhanced properties and uses thereof
US9315860B2 (en)	2009-10-26	2016-04-19	Genovoxx Gmbh	Conjugates of nucleotides and method for the application thereof
EP2517025B1 (en)	2009-12-23	2019-11-27	Bio-Rad Laboratories, Inc.	Methods for reducing the exchange of molecules between droplets
US8422031B2 (en)	2010-02-01	2013-04-16	Illumina, Inc.	Focusing methods and optical systems and assemblies using the same
US9605307B2 (en)	2010-02-08	2017-03-28	Genia Technologies, Inc.	Systems and methods for forming a nanopore in a lipid bilayer
US9678055B2 (en)	2010-02-08	2017-06-13	Genia Technologies, Inc.	Methods for forming a nanopore in a lipid bilayer
US20110192723A1 (en) *	2010-02-08	2011-08-11	Genia Technologies, Inc.	Systems and methods for manipulating a molecule in a nanopore
US8324914B2 (en)	2010-02-08	2012-12-04	Genia Technologies, Inc.	Systems and methods for characterizing a molecule
US10351905B2 (en)	2010-02-12	2019-07-16	Bio-Rad Laboratories, Inc.	Digital analyte analysis
US8535889B2 (en)	2010-02-12	2013-09-17	Raindance Technologies, Inc.	Digital analyte analysis
US9399797B2 (en)	2010-02-12	2016-07-26	Raindance Technologies, Inc.	Digital analyte analysis
US9366632B2 (en)	2010-02-12	2016-06-14	Raindance Technologies, Inc.	Digital analyte analysis
EP2539464B1 (en)	2010-02-23	2016-11-16	Illumina, Inc.	Amplification methods to minimise sequence specific bias
CN202281746U (zh)	2010-03-06	2012-06-20	伊鲁米那股份有限公司	检测来自样品光信号的测定设备及其光学组件和光学系统
US8951940B2 (en)	2010-04-01	2015-02-10	Illumina, Inc.	Solid-phase clonal amplification and related methods
CA2794522C (en)	2010-04-05	2019-11-26	Prognosys Biosciences, Inc.	Spatially encoded biological assays
US10787701B2 (en)	2010-04-05	2020-09-29	Prognosys Biosciences, Inc.	Spatially encoded biological assays
US20190300945A1 (en)	2010-04-05	2019-10-03	Prognosys Biosciences, Inc.	Spatially Encoded Biological Assays
WO2011159942A1 (en)	2010-06-18	2011-12-22	Illumina, Inc.	Conformational probes and methods for sequencing nucleic acids
US8986930B2 (en)	2010-07-12	2015-03-24	Pacific Biosciences Of California, Inc.	Sequencing reactions with alkali metal cations for pulse width control
US9029103B2 (en)	2010-08-27	2015-05-12	Illumina Cambridge Limited	Methods for sequencing polynucleotides
CA2810520C (en)	2010-09-10	2019-03-12	Bio-Rad Laboratories, Inc.	Size selection of dna for chromatin analysis
US8483969B2 (en)	2010-09-17	2013-07-09	Illuminia, Inc.	Variation analysis for multiple templates on a solid support
WO2012050920A1 (en)	2010-09-29	2012-04-19	Illumina, Inc.	Compositions and methods for sequencing nucleic acids
EP3447155A1 (en)	2010-09-30	2019-02-27	Raindance Technologies, Inc.	Sandwich assays in droplets
US8753816B2 (en)	2010-10-26	2014-06-17	Illumina, Inc.	Sequencing methods
EP3928867B1 (en)	2010-10-27	2024-07-17	Illumina, Inc.	Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same
US8575071B2 (en)	2010-11-03	2013-11-05	Illumina, Inc.	Reducing adapter dimer formation
EP2635679B1 (en)	2010-11-05	2017-04-19	Illumina, Inc.	Linking sequence reads using paired code tags
US9074251B2 (en)	2011-02-10	2015-07-07	Illumina, Inc.	Linking sequence reads using paired code tags
WO2012078312A2 (en)	2010-11-12	2012-06-14	Gen9, Inc.	Methods and devices for nucleic acids synthesis
WO2012064975A1 (en)	2010-11-12	2012-05-18	Gen9, Inc.	Protein arrays and methods of using and making the same
WO2012074855A2 (en)	2010-11-22	2012-06-07	The Regents Of The University Of California	Methods of identifying a cellular nascent rna transcript
WO2013082164A1 (en)	2011-11-28	2013-06-06	Life Technologies Corporation	Enhanced ligation reactions
WO2012088339A2 (en)	2010-12-22	2012-06-28	Genia Technologies, Inc.	Nanopore-based single dna molecule characterization using speed bumps
US9163281B2 (en)	2010-12-23	2015-10-20	Good Start Genetics, Inc.	Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US8951781B2 (en)	2011-01-10	2015-02-10	Illumina, Inc.	Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US8883764B1 (en)	2011-01-19	2014-11-11	Illumina, Inc.	Formylpyrrole-based heterocycles for nucleic acid attachment to supports
US8962242B2 (en)	2011-01-24	2015-02-24	Genia Technologies, Inc.	System for detecting electrical properties of a molecular complex
US9110478B2 (en)	2011-01-27	2015-08-18	Genia Technologies, Inc.	Temperature regulation of measurement arrays
EP2670864B1 (en)	2011-01-31	2017-03-08	Illumina, Inc.	Methods for reducing nucleic acid damage
AU2012212148B8 (en)	2011-02-02	2017-07-06	University Of Washington Through Its Center For Commercialization	Massively parallel contiguity mapping
US9364803B2 (en)	2011-02-11	2016-06-14	Raindance Technologies, Inc.	Methods for forming mixed droplets
EP2675819B1 (en)	2011-02-18	2020-04-08	Bio-Rad Laboratories, Inc.	Compositions and methods for molecular labeling
GB201106254D0 (en)	2011-04-13	2011-05-25	Frisen Jonas	Method and product
DE102012008375A1 (de)	2011-04-27	2012-10-31	Genovoxx Gmbh	Methoden und Komponenten zur Detektion von Nukleinsäureketten
WO2012150035A1 (de)	2011-05-04	2012-11-08	Genovoxx Gmbh	Nukleosid-triphosphat-konjugate und methoden zu deren anwendung
US9624539B2 (en)	2011-05-23	2017-04-18	The Trustees Of Columbia University In The City Of New York	DNA sequencing by synthesis using Raman and infrared spectroscopy detection
US8841071B2 (en)	2011-06-02	2014-09-23	Raindance Technologies, Inc.	Sample multiplexing
US9556470B2 (en)	2011-06-02	2017-01-31	Raindance Technologies, Inc.	Enzyme quantification
WO2012170936A2 (en)	2011-06-09	2012-12-13	Illumina, Inc.	Patterned flow-cells useful for nucleic acid analysis
EP2729580B1 (en)	2011-07-08	2015-09-16	Keygene N.V.	Sequence based genotyping based on oligonucleotide ligation assays
US8658430B2 (en)	2011-07-20	2014-02-25	Raindance Technologies, Inc.	Manipulating droplet size
EP2944693B1 (en)	2011-08-26	2019-04-24	Gen9, Inc.	Compositions and methods for high fidelity assembly of nucleic acids
CN104024269B (zh)	2011-09-13	2017-05-24	激光基因公司	5‑甲氧基，3’‑oh未阻断，可快速光切割的终止核苷酸以及用于核酸测序的方法
AU2012316218B2 (en)	2011-09-26	2016-03-17	Gen-Probe Incorporated	Algorithms for sequence determinations
US10378051B2 (en)	2011-09-29	2019-08-13	Illumina Cambridge Limited	Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing
WO2013058907A1 (en)	2011-10-17	2013-04-25	Good Start Genetics, Inc.	Analysis methods
WO2013063382A2 (en)	2011-10-28	2013-05-02	Illumina, Inc.	Microarray fabrication system and method
WO2013070627A2 (en)	2011-11-07	2013-05-16	Illumina, Inc.	Integrated sequencing apparatuses and methods of use
WO2013085710A2 (en)	2011-12-09	2013-06-13	Illumina, Inc.	Expanded radix for polymeric tags
US9279154B2 (en)	2011-12-21	2016-03-08	Illumina, Inc.	Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
WO2013117595A2 (en)	2012-02-07	2013-08-15	Illumina Cambridge Limited	Targeted enrichment and amplification of nucleic acids on a support
WO2013126741A1 (en)	2012-02-24	2013-08-29	Raindance Technologies, Inc.	Labeling and sample preparation for sequencing
US8986629B2 (en)	2012-02-27	2015-03-24	Genia Technologies, Inc.	Sensor circuit for controlling, detecting, and measuring a molecular complex
NO2694769T3 (pt)	2012-03-06	2018-03-03
US9150853B2 (en)	2012-03-21	2015-10-06	Gen9, Inc.	Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US20130261984A1 (en)	2012-03-30	2013-10-03	Illumina, Inc.	Methods and systems for determining fetal chromosomal abnormalities
WO2013150902A1 (ja) *	2012-04-02	2013-10-10	独立行政法人理化学研究所	非天然型塩基を含むオリゴデオキシヌクレオチドの切断による5'末端リン酸化オリゴデオキシヌクレオチドの製造方法
ES2949570T3 (es)	2012-04-03	2023-09-29	Illumina Inc	Cabezal integrado de lectura optoelectrónica y cartucho de fluidos útiles para la secuenciación de ácidos nucleicos
US8209130B1 (en)	2012-04-04	2012-06-26	Good Start Genetics, Inc.	Sequence assembly
US8812422B2 (en)	2012-04-09	2014-08-19	Good Start Genetics, Inc.	Variant database
US9444880B2 (en)	2012-04-11	2016-09-13	Illumina, Inc.	Cloud computing environment for biological data
US20130274148A1 (en)	2012-04-11	2013-10-17	Illumina, Inc.	Portable genetic detection and analysis system and method
US10227635B2 (en)	2012-04-16	2019-03-12	Molecular Loop Biosolutions, Llc	Capture reactions
CN111876409A (zh)	2012-04-24	2020-11-03	Gen9股份有限公司	在体外克隆中分选核酸和多重制备物的方法
GB2557509A (en)	2012-06-08	2018-06-20	Pacific Biosciences California Inc	Modified base detection with nanopore sequencing
US9012022B2 (en)	2012-06-08	2015-04-21	Illumina, Inc.	Polymer coatings
CN104350162A (zh)	2012-06-15	2015-02-11	吉尼亚科技公司	芯片设置和高精确度核酸测序
US8895249B2 (en)	2012-06-15	2014-11-25	Illumina, Inc.	Kinetic exclusion amplification of nucleic acid libraries
WO2014004393A1 (en)	2012-06-25	2014-01-03	Gen9, Inc.	Methods for nucleic acid assembly and high throughput sequencing
WO2014008448A1 (en)	2012-07-03	2014-01-09	Sloan Kettering Institute For Cancer Research	Quantitative assessment of human t-cell repertoire recovery after allogeneic hematopoietic stem cell transplantation
EP3243937A1 (en)	2012-07-17	2017-11-15	Counsyl, Inc.	System and methods for detecting genetic variation
US9092401B2 (en)	2012-10-31	2015-07-28	Counsyl, Inc.	System and methods for detecting genetic variation
US9422602B2 (en)	2012-08-15	2016-08-23	Bio-Rad Laboratories, Inc.	Methods and compositions for determining nucleic acid degradation
NL2017959B1 (en)	2016-12-08	2018-06-19	Illumina Inc	Cartridge assembly
CA3040684C (en)	2012-08-20	2023-02-07	Hod Finkelstein	Method and system for fluorescence lifetime based sequencing
US9150896B2 (en)	2012-09-06	2015-10-06	Illumina, Inc.	Nucleotides and primers with removable blocking groups
BR112015005857A2 (pt)	2012-09-19	2017-08-08	Abbvie Biotherapeutics Inc	métodos para identificação de anticorpos com imunogenicidade reduzida
US9399766B2 (en)	2012-10-01	2016-07-26	Pacific Biosciences Of California, Inc.	Recombinant polymerases for incorporation of protein shield nucleotide analogs
CA2886974C (en)	2012-10-17	2021-06-29	Spatial Transcriptomics Ab	Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
US9181583B2 (en)	2012-10-23	2015-11-10	Illumina, Inc.	HLA typing using selective amplification and sequencing
US9116139B2 (en)	2012-11-05	2015-08-25	Illumina, Inc.	Sequence scheduling and sample distribution techniques
US9605309B2 (en)	2012-11-09	2017-03-28	Genia Technologies, Inc.	Nucleic acid sequencing using tags
MX2015006219A (es)	2012-11-19	2015-11-13	Apton Biosystems Inc	Analisis digital de analitos moleculares usando deteccion de molecula individual.
US10829816B2 (en)	2012-11-19	2020-11-10	Apton Biosystems, Inc.	Methods of analyte detection
US9683230B2 (en)	2013-01-09	2017-06-20	Illumina Cambridge Limited	Sample preparation on a solid support
CN103087131B (zh) *	2013-01-15	2015-07-08	上海交通大学	可逆终端及其合成和在dna合成测序中的用途
US9805407B2 (en)	2013-01-25	2017-10-31	Illumina, Inc.	Methods and systems for using a cloud computing environment to configure and sell a biological sample preparation cartridge and share related data
US9759711B2 (en)	2013-02-05	2017-09-12	Genia Technologies, Inc.	Nanopore arrays
US9512422B2 (en)	2013-02-26	2016-12-06	Illumina, Inc.	Gel patterned surfaces
US9650406B2 (en)	2013-02-28	2017-05-16	Centrillion Technology Holdings Corporation	Reversible terminator molecules and methods of their use
EP2964785B8 (en)	2013-03-04	2020-10-21	Fry Laboratories LLC	Method and kit for characterizing microorganisms
US9873913B2 (en)	2013-03-08	2018-01-23	Roche Molecular Systems, Inc.	Mutation testing
DK2969479T3 (da)	2013-03-13	2021-08-02	Illumina Inc	Væskeanordninger i flere lag og fremgangsmåder til deres fremstilling
DK3553175T3 (da)	2013-03-13	2021-08-23	Illumina Inc	Fremgangsmåde til fremstilling af et nukleinsyresekvenseringsbibliotek
EP2971159B1 (en)	2013-03-14	2019-05-08	Molecular Loop Biosolutions, LLC	Methods for analyzing nucleic acids
AU2013382024B2 (en)	2013-03-14	2019-01-31	Illumina, Inc.	Modified polymerases for improved incorporation of nucleotide analogues
US9146248B2 (en)	2013-03-14	2015-09-29	Intelligent Bio-Systems, Inc.	Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9193998B2 (en)	2013-03-15	2015-11-24	Illumina, Inc.	Super resolution imaging
US20140274747A1 (en)	2013-03-15	2014-09-18	Illumina, Inc.	Super resolution imaging
US9255265B2 (en)	2013-03-15	2016-02-09	Illumina, Inc.	Methods for producing stranded cDNA libraries
WO2014142981A1 (en)	2013-03-15	2014-09-18	Illumina, Inc.	Enzyme-linked nucleotides
KR102230831B1 (ko) *	2013-03-15	2021-03-22	일루미나 케임브리지 리미티드	변형된 뉴클레오사이드 또는 뉴클레오타이드
US9591268B2 (en)	2013-03-15	2017-03-07	Qiagen Waltham, Inc.	Flow cell alignment methods and systems
WO2014144883A1 (en)	2013-03-15	2014-09-18	The Trustees Of Columbia University In The City Of New York	Raman cluster tagged molecules for biological imaging
US8847799B1 (en)	2013-06-03	2014-09-30	Good Start Genetics, Inc.	Methods and systems for storing sequence read data
WO2014210225A1 (en)	2013-06-25	2014-12-31	Prognosys Biosciences, Inc.	Methods and systems for determining spatial patterns of biological targets in a sample
DK3017065T3 (en)	2013-07-01	2018-11-26	Illumina Inc	Catalyst-free Surface functionalization and polymer grafting
EP3241913B1 (en)	2013-07-03	2019-02-20	Illumina, Inc.	System for sequencing by orthogonal synthesis
CA3009218C (en)	2013-08-08	2020-10-27	Illumina, Inc.	Fluidic system for reagent delivery to a flow cell
JP6585046B2 (ja)	2013-08-22	2019-10-02	アプトンバイオシステムズインコーポレイテッド	電気的方法を用いた分子分析物のデジタル分析の方法
KR20160081896A (ko)	2013-08-30	2016-07-08	일루미나, 인코포레이티드	친수성 또는 다양한-친수성 표면 상에서의 액적의 조작
CN103484106B (zh) *	2013-09-05	2015-08-19	上海交通大学	四色荧光标记可逆终端及其在dna测序中的用途
US9352315B2 (en)	2013-09-27	2016-05-31	Taiwan Semiconductor Manufacturing Company, Ltd.	Method to produce chemical pattern in micro-fluidic structure
JP6532456B2 (ja)	2013-10-04	2019-06-19	ライフテクノロジーズコーポレーション	終止化学を用いる配列決定における整相効果（ｐｈａｓｉｎｇｅｆｆｅｃｔｓ）をモデル化するための方法及びシステム
US11901041B2 (en)	2013-10-04	2024-02-13	Bio-Rad Laboratories, Inc.	Digital analysis of nucleic acid modification
US9551697B2 (en)	2013-10-17	2017-01-24	Genia Technologies, Inc.	Non-faradaic, capacitively coupled measurement in a nanopore cell array
US10851414B2 (en)	2013-10-18	2020-12-01	Good Start Genetics, Inc.	Methods for determining carrier status
EP3058096A1 (en)	2013-10-18	2016-08-24	Good Start Genetics, Inc.	Methods for assessing a genomic region of a subject
US9567630B2 (en)	2013-10-23	2017-02-14	Genia Technologies, Inc.	Methods for forming lipid bilayers on biochips
EP3060918B1 (en)	2013-10-23	2019-09-18	Genia Technologies, Inc.	High speed molecular sensing with nanopores
US10540783B2 (en) *	2013-11-01	2020-01-21	Illumina, Inc.	Image analysis useful for patterned objects
KR102221637B1 (ko)	2013-11-17	2021-03-02	퀀텀-에스아이 인코포레이티드	분자들을 검사, 검출 및 분석하기 위한 광 시스템 및 어세이 칩
EP2876166B1 (en) *	2013-11-20	2016-12-14	Roche Diagnostics GmbH	New compound for sequencing by synthesis
PL3077943T3 (pl)	2013-12-03	2020-11-30	Illumina, Inc.	Sposoby i układy do analizy danych obrazowych
ES2971473T3 (es)	2013-12-10	2024-06-05	Illumina Inc	Biosensores para análisis biológicos o químicos y métodos para la fabricación de los mismos
US9944977B2 (en)	2013-12-12	2018-04-17	Raindance Technologies, Inc.	Distinguishing rare variations in a nucleic acid sequence from a sample
EP3083994B1 (en)	2013-12-20	2021-08-18	Illumina, Inc.	Preserving genomic connectivity information in fragmented genomic dna samples
KR102333635B1 (ko)	2013-12-23	2021-11-30	일루미나, 인코포레이티드	광 방출의 검출을 개선시키기 위한 구조화 기판 및 이와 관련한 방법
US10537889B2 (en)	2013-12-31	2020-01-21	Illumina, Inc.	Addressable flow cell using patterned electrodes
US11193176B2 (en)	2013-12-31	2021-12-07	Bio-Rad Laboratories, Inc.	Method for detecting and quantifying latent retroviral RNA species
US9926598B2 (en)	2014-01-16	2018-03-27	Illumina, Inc.	Amplicon preparation and sequencing on solid supports
US9677132B2 (en)	2014-01-16	2017-06-13	Illumina, Inc.	Polynucleotide modification on solid support
BR112016018547B1 (pt)	2014-02-13	2023-12-12	Illumina, Inc	Método para processar informações genômicas
EP3910069A1 (en)	2014-02-18	2021-11-17	Illumina, Inc.	Methods and composition for dna profiling
EP3116651B1 (en)	2014-03-11	2020-04-22	Illumina, Inc.	Disposable, integrated microfluidic cartridge and methods of making it
FR3020071B1 (fr)	2014-04-17	2017-12-22	Dna Script	Procede de synthese d'acides nucleiques, notamment d'acides nucleiques de grande longueur, utilisation du procede et kit pour la mise en œuvre du procede
EP3680333A1 (en)	2014-04-29	2020-07-15	Illumina, Inc.	Multiplexed single cell expression analysis using template switch and tagmentation
US11053548B2 (en)	2014-05-12	2021-07-06	Good Start Genetics, Inc.	Methods for detecting aneuploidy
AU2015259024B2 (en)	2014-05-16	2021-07-01	Illumina, Inc.	Nucleic acid synthesis techniques
WO2015183871A1 (en)	2014-05-27	2015-12-03	Illumina, Inc.	Systems and methods for biochemical analysis including a base instrument and a removable cartridge
ES2846746T3 (es)	2014-06-03	2021-07-29	Illumina Inc	Composiciones, sistemas y métodos para detectar acontecimientos usando fijaciones ancladas o adyacentes a nanoporos
US20150353989A1 (en)	2014-06-09	2015-12-10	Illumina Cambridge Limited	Sample preparation for nucleic acid amplification
EP3155125A1 (en)	2014-06-13	2017-04-19	Illumina Cambridge Limited	Methods and compositions for preparing sequencing libraries
US10829814B2 (en)	2014-06-19	2020-11-10	Illumina, Inc.	Methods and compositions for single cell genomics
US10017759B2 (en)	2014-06-26	2018-07-10	Illumina, Inc.	Library preparation of tagged nucleic acid
JP6737710B2 (ja)	2014-06-27	2020-08-12	イルミナインコーポレイテッド	ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ
EP3161152B1 (en)	2014-06-30	2018-12-26	Illumina, Inc.	Methods and compositions using one-sided transposition
EP3169805B1 (en)	2014-07-15	2018-08-29	Illumina, Inc.	Biochemically activated electronic device
SG11201702066UA (en)	2014-07-21	2017-04-27	Illumina Inc	Polynucleotide enrichment using crispr-cas systems
US10174363B2 (en)	2015-05-20	2019-01-08	Quantum-Si Incorporated	Methods for nucleic acid sequencing
GB201414098D0 (en)	2014-08-08	2014-09-24	Illumina Cambridge Ltd	Modified nucleotide linkers
KR102384909B1 (ko)	2014-08-08	2022-04-11	퀀텀-에스아이 인코포레이티드	수신된 광자들의 시간 비닝을 위한 집적 디바이스
CA2957546A1 (en)	2014-08-08	2016-02-11	Quantum-Si Incorporated	Integrated device with external light source for probing, detecting, and analyzing molecules
JP6812341B2 (ja)	2014-08-08	2021-01-13	クアンタム−エスアイインコーポレイテッドＱｕａｎｔｕｍ−ＳｉＩｎｃｏｒｐｏｒａｔｅｄ	分子の探索、検出及び解析のための光学システム及びアッセイチップ
WO2016026924A1 (en)	2014-08-21	2016-02-25	Illumina Cambridge Limited	Reversible surface functionalization
FR3025201B1 (fr)	2014-09-02	2018-10-12	Dna Script	Nucleotides modifies pour la synthese d'acides nucleiques, un kit renfermant de tels nucleotides et leur utilisation pour la production de genes ou sequences d'acides nucleiques synthetiques
WO2016040446A1 (en)	2014-09-10	2016-03-17	Good Start Genetics, Inc.	Methods for selectively suppressing non-target sequences
WO2016040602A1 (en)	2014-09-11	2016-03-17	Epicentre Technologies Corporation	Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
ES2803079T3 (es)	2014-09-12	2021-01-22	Illumina Inc	Métodos para detectar la presencia de subunidades de polímeros usando quimioluminiscencia
WO2016044233A1 (en)	2014-09-18	2016-03-24	Illumina, Inc.	Methods and systems for analyzing nucleic acid sequencing data
CA2999708A1 (en)	2014-09-24	2016-03-31	Good Start Genetics, Inc.	Process control for increased robustness of genetic assays
CN107002051A (zh)	2014-09-30	2017-08-01	亿明达股份有限公司	用于核苷酸类似物的改善的掺入的经修饰的聚合酶
US10487357B2 (en)	2014-10-03	2019-11-26	Life Technologies Corporation	Methods of nucleic acid analysis using terminator nucleotides
US10544455B2 (en)	2014-10-03	2020-01-28	Life Technologies Corporation	Sequencing methods, compositions and systems using terminator nucleotides
BR112017005038B1 (pt)	2014-10-09	2022-01-25	Illumina, Inc	Método e dispositivo para separar líquidos imiscíveis para isolar efetivamente pelo menos um dos líquidos
US9897791B2 (en)	2014-10-16	2018-02-20	Illumina, Inc.	Optical scanning systems for in situ genetic analysis
RU2709655C2 (ru)	2014-10-17	2019-12-19	Иллумина Кембридж Лимитед	Транспозиция с сохранением сцепления генов
EP3699283A1 (en)	2014-10-20	2020-08-26	Molecular Assemblies Inc.	Modified template-independent enzymes for polydeoxynucleotide systhesis
CN107074904B (zh)	2014-10-23	2022-12-23	深圳华大智造科技股份有限公司	信号约束测序(scs)和用于信号约束测序的核苷酸类似物
JP6759197B2 (ja)	2014-10-31	2020-09-23	イルミナケンブリッジリミテッド	新規のポリマーおよびｄｎａコポリマーコーティング
US10000799B2 (en)	2014-11-04	2018-06-19	Boreal Genomics, Inc.	Methods of sequencing with linked fragments
ES2768762T3 (es)	2014-11-05	2020-06-23	Illumina Cambridge Ltd	Reducción del daño al ADN durante la preparación de muestras y secuenciación usando agentes quelantes sideróforos
GB201419731D0 (en)	2014-11-05	2014-12-17	Illumina Cambridge Ltd	Sequencing from multiple primers to increase data rate and density
ES2802405T3 (es)	2014-11-11	2021-01-19	Illumina Cambridge Ltd	Métodos y matrices para producir y secuenciar agrupaciones monoclonales de ácido nucleico
ES2706531T3 (es)	2014-11-11	2019-03-29	Illumina Inc	Amplificación de polinucleótidos empleando sistemas CRISPR-Cas
US10584366B2 (en)	2014-12-03	2020-03-10	IsoPlexis Corporation	Analysis and screening of cell secretion profiles
ES2870097T3 (es)	2014-12-15	2021-10-26	Illumina Inc	Método de colocación molecular individual sobre un sustrato
WO2016112073A1 (en)	2015-01-06	2016-07-14	Good Start Genetics, Inc.	Screening for structural variants
SG11201706504RA (en)	2015-02-10	2017-09-28	Illumina Inc	Methods and compositions for analyzing cellular components
US10576471B2 (en)	2015-03-20	2020-03-03	Illumina, Inc.	Fluidics cartridge for use in the vertical or substantially vertical position
WO2016154193A1 (en)	2015-03-24	2016-09-29	Illumina, Inc.	Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
EP3274473B1 (en)	2015-03-24	2020-10-28	Pacific Biosciences of California, Inc.	Methods and compositions for single molecule composition loading
WO2016156845A1 (en)	2015-03-31	2016-10-06	Illumina Cambridge Limited	Surface concatamerization of templates
ES2955916T3 (es)	2015-04-10	2023-12-11	Spatial Transcriptomics Ab	Análisis múltiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos
WO2016168386A1 (en)	2015-04-14	2016-10-20	Illumina, Inc.	Structured substrates for improving detection of light emissions and methods relating to the same
US10844428B2 (en)	2015-04-28	2020-11-24	Illumina, Inc.	Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
EP3091026B1 (en) *	2015-05-08	2019-02-20	Centrillion Technology Holdings Corporation	Disulfide-linked reversible terminators
JP2018518157A (ja)	2015-05-11	2018-07-12	イラミーナインコーポレーテッド	治療薬剤の発見および分析のためのプラットフォーム
JP6692831B2 (ja)	2015-05-12	2020-05-13	イラミーナインコーポレーテッド	核酸をシーケンシングするための電界効果装置および方法
US10640809B2 (en)	2015-05-29	2020-05-05	Epicentre Technologies Corporation	Methods of analyzing nucleic acids
ES2789349T3 (es)	2015-05-29	2020-10-26	Illumina Cambridge Ltd	Utilización mejorada de cebadores de superficie en grupos
KR102134953B1 (ko)	2015-05-29	2020-07-16	일루미나, 인코포레이티드	지정된 반응을 수행하기 위한 샘플 캐리어 및 검정 시스템
CN114703264B (zh)	2015-06-03	2024-09-20	亿明达股份有限公司	使用锚定至邻近纳米孔的聚合酶的系链对多核苷酸测序的组合物、系统和方法
EP3307908B1 (en)	2015-06-09	2019-09-11	Life Technologies Corporation	Methods for molecular tagging
WO2016205753A1 (en)	2015-06-17	2016-12-22	The Translational Genomics Research Institute	Systems and methods for obtaining biological molecules from a sample
WO2017007757A1 (en)	2015-07-06	2017-01-12	Illumina, Inc.	Balanced ac modulation for driving droplet operations electrodes
EP3878974A1 (en)	2015-07-06	2021-09-15	Illumina Cambridge Limited	Sample preparation for nucleic acid amplification
EP3320399A1 (en)	2015-07-07	2018-05-16	Illumina, Inc.	Selective surface patterning via nanoimprinting
CN107835857A (zh)	2015-07-17	2018-03-23	亿明达股份有限公司	用于测序应用的聚合物片层
JP6962914B2 (ja)	2015-07-20	2021-11-05	センティルスホールディングカンパニーエルエルシーSentilus Holdco, Llc	チップ、検出器、ならびにそれらの製造方法および使用方法
EP3957747A1 (en)	2015-07-27	2022-02-23	Illumina, Inc.	Spatial mapping of nucleic acid sequence information
AU2016298541B2 (en)	2015-07-30	2019-10-31	Illumina, Inc.	Orthogonal deblocking of nucleotides
PL3334839T3 (pl)	2015-08-14	2021-08-02	Illumina, Inc.	Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej
US10976334B2 (en)	2015-08-24	2021-04-13	Illumina, Inc.	In-line pressure accumulator and flow-control system for biological or chemical assays
AU2016316773B2 (en)	2015-08-28	2020-01-30	Illumina, Inc.	Nucleic acid sequence analysis from single cells
CN107921432A (zh)	2015-09-02	2018-04-17	伊卢米纳剑桥有限公司	改善流控系统中的液滴操作的系统和方法
US10647981B1 (en)	2015-09-08	2020-05-12	Bio-Rad Laboratories, Inc.	Nucleic acid library generation methods and compositions
US10450598B2 (en)	2015-09-11	2019-10-22	Illumina, Inc.	Systems and methods for obtaining a droplet having a designated concentration of a substance-of-interest
CN108779138B (zh) *	2015-09-28	2022-06-17	哥伦比亚大学董事会	用作dna合成测序的可逆终止物的基于新的二硫键接头的核苷酸的设计与合成
JP6657721B2 (ja)	2015-09-30	2020-03-04	ソニー株式会社	細胞の分析方法、細胞分析用チップ、細胞分析用試薬、細胞分析用キット及び細胞分析用装置
US10577643B2 (en)	2015-10-07	2020-03-03	Illumina, Inc.	Off-target capture reduction in sequencing techniques
US10465232B1 (en)	2015-10-08	2019-11-05	Trace Genomics, Inc.	Methods for quantifying efficiency of nucleic acid extraction and detection
CN108290157B (zh)	2015-10-22	2021-08-17	亿明达股份有限公司	用于流体装置的填充流体
AU2016349457B2 (en)	2015-11-06	2022-09-22	Qiagen Sciences Llc	Nucleotide analogues
US11421264B2 (en)	2015-11-06	2022-08-23	IsoPlexis Corporation	Thiol-containing cleave reagents and oxidative wash
JP6942362B2 (ja)	2015-11-09	2021-09-29	ラディアクションリミテッド	放射線遮蔽装置およびその用途
WO2017087724A1 (en)	2015-11-17	2017-05-26	Omniome, Inc.	Methods for determining sequence profiles
WO2017087696A1 (en)	2015-11-18	2017-05-26	Pacific Biosciences Of California, Inc.	Methods and compositions for loading of polymerase complexes
CA3005671A1 (en)	2015-11-19	2017-05-26	Peking University	Methods for obtaining and correcting biological sequence information
ES2875759T3 (es)	2015-12-01	2021-11-11	Illumina Inc	Sistema microfluídico digital para aislamiento de células individuales y caracterización de analitos
EP3390657B1 (en)	2015-12-17	2020-09-16	Illumina, Inc.	Distinguishing methylation levels in complex biological samples
DE202017100081U1 (de)	2016-01-11	2017-03-19	Illumina, Inc.	Detektionsvorrichtung mit einem Mikrofluorometer, einem fluidischen System und einem Durchflusszellen-Rastklemmenmodul
CN108780044A (zh)	2016-02-17	2018-11-09	泰斯艾科特健康公司	用于寿命成像和检测应用的传感器和设备
EP4053545A1 (en)	2016-03-24	2022-09-07	Illumina, Inc.	Photonic superlattice-based devices and compositions for use in luminescent imaging, and methods of using the same
US10801059B2 (en)	2016-03-28	2020-10-13	Boreal Genomics, Inc.	Droplet-based linked-fragment sequencing
SG11201805665UA (en)	2016-03-28	2018-10-30	Illumina Inc	Multi-plane microarrays
US10961573B2 (en)	2016-03-28	2021-03-30	Boreal Genomics, Inc.	Linked duplex target capture
CN109562142B (zh) *	2016-04-04	2022-09-13	纽约哥伦比亚大学董事会	使用核苷酸类似物和拉曼检测的dna合成测序
WO2017177017A1 (en)	2016-04-07	2017-10-12	Omniome, Inc.	Methods of quantifying target nucleic acids and identifying sequence variants
EP3440220B1 (en)	2016-04-07	2020-03-25	Illumina, Inc.	Methods and systems for construction of normalized nucleic acid libraries
AU2017254688B2 (en)	2016-04-22	2020-05-14	Pacific Biosciences Of California, Inc.	Nucleic acid sequencing method and system employing enhanced detection of nucleotide-specific ternary complex formation
EP3446157B1 (en)	2016-04-22	2023-05-17	Illumina, Inc.	Photonic stucture-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same
CA3022431C (en)	2016-04-29	2023-03-21	Omniome, Inc.	Method of nucleic acid sequence determination
WO2017190018A1 (en)	2016-04-29	2017-11-02	Omniome, Inc.	Sequencing method employing ternary complex destabilization to identify cognate nucleotides
US10597643B2 (en)	2016-04-29	2020-03-24	Omniome, Inc.	Polymerases engineered to reduce nucleotide-independent DNA binding
WO2017197027A1 (en)	2016-05-11	2017-11-16	Illumina, Inc.	Polynucleotide enrichment and amplification using argonaute systems
US20170327876A1 (en) *	2016-05-16	2017-11-16	Nanostring Technologies, Inc.	Methods for detecting target nucleic acids in a sample
ES2861478T3 (es)	2016-05-18	2021-10-06	Illumina Inc	Estampación de autoensamblado que utiliza superficies hidrófobas estampadas
EP3463381A4 (en) *	2016-05-23	2020-01-01	The Trustees of Columbia University in the City of New York	NUCLEOTIDE DERIVATIVES AND THEIR METHODS OF USE
SG11201810907UA (en)	2016-06-06	2019-01-30	Redvault Biosciences Lp	Target reporter constructs and uses thereof
EP3904514A1 (en)	2016-07-22	2021-11-03	Oregon Health & Science University	Single cell whole genome libraries and combinatorial indexing methods of making thereof
KR102230444B1 (ko)	2016-08-15	2021-03-23	옴니옴 인코포레이티드	핵산을 시퀀싱하기 위한 방법 및 시스템
WO2018034780A1 (en)	2016-08-15	2018-02-22	Omniome, Inc.	Sequencing method for rapid identification and processing of cognate nucleotide pairs
US20230207048A1 (en)	2016-09-22	2023-06-29	Illumina, Inc.	Somatic copy number variation detection
WO2018064116A1 (en)	2016-09-28	2018-04-05	Illumina, Inc.	Methods and systems for data compression
TWI781669B (zh)	2016-10-14	2022-10-21	美商伊路米納有限公司	卡匣總成
WO2018075785A1 (en)	2016-10-19	2018-04-26	Illumina, Inc.	Methods for chemical ligation of nucleic acids
CA3041055A1 (en) *	2016-11-04	2018-05-11	Qiagen Sciences, Llc	Thiol-containing cleave reagents and oxidative wash
DK3538891T3 (da)	2016-11-11	2022-03-28	Isoplexis Corp	Sammensætninger og fremgangsmåder til samtidig genomisk, transkriptomisk og proteomisk analyse af enkeltceller
CN110168648A (zh)	2016-11-16	2019-08-23	伊路米纳有限公司	序列变异识别的验证方法和系统
GB201619458D0 (en)	2016-11-17	2017-01-04	Spatial Transcriptomics Ab	Method for spatial tagging and analysing nucleic acids in a biological specimen
SG10202100951SA (en) *	2016-11-21	2021-03-30	Nanostring Technologies Inc	Chemical compositions and methods of using same
CN110226084A (zh)	2016-11-22	2019-09-10	伊索普莱克西斯公司	用于细胞捕获的系统、装置和方法，以及其制造方法
EP4119663B1 (en)	2016-12-09	2024-11-27	The Broad Institute, Inc.	Crispr effector system based diagnostics
US11268137B2 (en)	2016-12-09	2022-03-08	Boreal Genomics, Inc.	Linked ligation
IL267444B2 (en)	2016-12-22	2024-12-01	Illumina Inc	Arrays including a resin film and a patterned polymer layer
US20180195115A1 (en)	2016-12-22	2018-07-12	Illumina, Inc.	Arrays with quality control tracers
JP7149275B2 (ja)	2016-12-22	2022-10-06	クアンタム－エスアイインコーポレイテッド	直接ビニングピクセルを備える集積光検出器
IL267445B2 (en)	2016-12-22	2023-10-01	Illumina Inc	Array including sequencing primer and non-sequencing entity
EP3562962B1 (en)	2016-12-30	2022-01-05	Omniome, Inc.	Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
GB201704754D0 (en)	2017-01-05	2017-05-10	Illumina Inc	Kinetic exclusion amplification of nucleic acid libraries
BR112019013886A2 (pt)	2017-01-06	2020-03-03	Illumina, Inc.	Método para determinar os valores de cor corrigidos, e, sequenciador de ácidos nucleicos
WO2018128544A1 (en)	2017-01-06	2018-07-12	Agendia N.V.	Biomarkers for selecting patient groups, and uses thereof.
CA3049722C (en)	2017-01-10	2023-01-24	Omniome, Inc.	Polymerases engineered to reduce nucleotide-independent dna binding
US20200090784A1 (en)	2017-01-17	2020-03-19	Illumina, Inc.	Oncogenic splice variant determination
CN116497103A (zh)	2017-01-18	2023-07-28	伊鲁米那股份有限公司	制备测序衔接子的方法和对核酸分子进行测序的方法
CN110249059B (zh)	2017-01-20	2021-04-13	欧姆尼欧美公司	核酸的等位基因特异性捕获
EP3565900B1 (en)	2017-01-20	2021-04-07	Omniome, Inc.	Genotyping by polymerase binding
GB201700983D0 (en)	2017-01-20	2017-03-08	Life Tech As	Polymeric particles
CA3050695C (en)	2017-01-20	2024-02-20	Omniome, Inc.	Process for cognate nucleotide detection in a nucleic acid sequencing workflow
US11896944B2 (en)	2017-02-01	2024-02-13	Illumina, Inc.	System and method with fiducials responding to multiple excitation frequencies
GB201701689D0 (en)	2017-02-01	2017-03-15	Illumia Inc	System and method with fiducials of non-closed shapes
GB201701688D0 (en)	2017-02-01	2017-03-15	Illumia Inc	System and method with fiducials in non-recliner layouts
GB201701686D0 (en)	2017-02-01	2017-03-15	Illunina Inc	System & method with fiducials having offset layouts
US11492666B2 (en)	2017-02-15	2022-11-08	Pacific Biosciences Of California, Inc.	Distinguishing sequences by detecting polymerase dissociation
EP3494235A1 (en)	2017-02-17	2019-06-12	Stichting VUmc	Swarm intelligence-enhanced diagnosis and therapy selection for cancer using tumor- educated platelets
DK3452621T3 (da)	2017-02-21	2022-12-12	Illumina Inc	Tagmentation ved brug af immobiliserede transposomer med linkere
EP3596099B1 (en)	2017-03-06	2024-07-24	Singular Genomics Systems, Inc.	Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps
US11104937B2 (en)	2017-03-15	2021-08-31	The Broad Institute, Inc.	CRISPR effector system based diagnostics
US11021740B2 (en)	2017-03-15	2021-06-01	The Broad Institute, Inc.	Devices for CRISPR effector system based diagnostics
CA3056411A1 (en)	2017-03-15	2018-09-20	The Broad Institute, Inc.	Crispr effector system based diagnostics for virus detection
US11174515B2 (en)	2017-03-15	2021-11-16	The Broad Institute, Inc.	CRISPR effector system based diagnostics
JP7305611B2 (ja)	2017-03-17	2023-07-10	アプトンバイオシステムズインコーポレイテッド	配列決定および高分解能画像化の方法
SG10202109852WA (en)	2017-03-20	2021-10-28	Illumina Inc	Methods and compositions for preparing nucleic acid libraries
EP4053294A1 (en)	2017-03-24	2022-09-07	Life Technologies Corporation	Polynucleotide adapters and methods of use thereof
CN110709089B (zh) *	2017-03-28	2024-12-06	哥伦比亚大学董事会	用于连接荧光标记与用于dna合成测序的碱基的具有不同可裂解连接子的3’-o-改性的核苷酸类似物
WO2018187013A1 (en)	2017-04-04	2018-10-11	Omniome, Inc.	Fluidic apparatus and methods useful for chemical and biological reactions
DK3615691T3 (da)	2017-04-23	2021-07-26	Illumina Inc	Sammensætninger og fremgangsmåder til forbedring af prøveidentifikation i indekserede nukleinsyrebiblioteker
WO2018197945A1 (en)	2017-04-23	2018-11-01	Illumina Cambridge Limited	Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10995369B2 (en)	2017-04-23	2021-05-04	Illumina, Inc.	Compositions and methods for improving sample identification in indexed nucleic acid libraries
CN110785497A (zh)	2017-04-23	2020-02-11	伊鲁米纳剑桥有限公司	用于改进编索引的核酸文库中的样品鉴定的组合物和方法
US9951385B1 (en)	2017-04-25	2018-04-24	Omniome, Inc.	Methods and apparatus that increase sequencing-by-binding efficiency
US10161003B2 (en)	2017-04-25	2018-12-25	Omniome, Inc.	Methods and apparatus that increase sequencing-by-binding efficiency
AU2018261332B2 (en)	2017-05-01	2024-12-05	Illumina, Inc.	Optimal index sequences for multiplex massively parallel sequencing
AU2018266377B2 (en)	2017-05-08	2024-06-20	Illumina, Inc.	Universal short adapters for indexing of polynucleotide samples
SG10202108175RA (en)	2017-06-07	2021-09-29	Univ Oregon Health & Science	Single cell whole genome libraries for methylation sequencing
GB2578038B (en)	2017-06-16	2022-11-23	Life Technologies Corp	Control nucleic acids, and compositions, kits, and uses thereof
CN111032882A (zh)	2017-06-20	2020-04-17	伊鲁米那股份有限公司	解决扩增反应中低效的方法和组合物
GB201711219D0 (en)	2017-07-12	2017-08-23	Illumina Cambridge Ltd	Short pendant arm linkers for nucleotides in sequencing applications
WO2019018366A1 (en)	2017-07-18	2019-01-24	Omniome, Inc.	METHOD OF CHEMICAL MODIFICATION OF PLASTIC SURFACES
KR102626317B1 (ko)	2017-07-24	2024-01-18	퀀텀-에스아이 인코포레이티드	고강도 표지된 반응물 조성물 및 서열분석 방법
EP3658897A4 (en)	2017-07-24	2021-05-12	Quantum-si Incorporated	PORTABLE SOLID PARALLEL, BIO-OPTOELECTRONIC INSTRUMENT
WO2019027767A1 (en)	2017-07-31	2019-02-07	Illumina Inc.	SEQUENCING SYSTEM COMPRISING AGGREGATION OF MULTIPLEXED BIOLOGICAL SAMPLES
CN118086480A (zh)	2017-08-01	2024-05-28	深圳华大智造科技有限公司	核酸测序方法
KR102307473B1 (ko)	2017-08-01	2021-10-01	일루미나, 인코포레이티드	뉴클레오타이드 서열분석용 하이드로겔 비드
EP3545106B1 (en)	2017-08-01	2022-01-19	Helitec Limited	Methods of enriching and determining target nucleotide sequences
ES2999650T3 (en)	2017-08-01	2025-02-26	Illumina Inc	Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
WO2019030149A1 (en)	2017-08-07	2019-02-14	Dna Script	VARIANTS OF FAMILY A DNA POLYMERASE AND USES THEREOF
CN114563419A (zh)	2017-08-15	2022-05-31	加利福尼亚太平洋生物科学股份有限公司	用于检测化学和生物分析物的扫描装置和方法
CN110678559B (zh) *	2017-08-31	2023-09-15	深圳华大智造科技股份有限公司	一种核酸探针以及一种核酸测序方法
US11447818B2 (en)	2017-09-15	2022-09-20	Illumina, Inc.	Universal short adapters with variable length non-random unique molecular identifiers
RU2020113600A (ru)	2017-09-20	2021-10-20	Ридженерон Фармасьютикалз, Инк.	Способы иммунотерапии пациентов, опухоли которых характеризуются высокой нагрузкой пассажирскими генными мутациями
US11597965B2 (en)	2017-10-06	2023-03-07	10X Genomics, Inc.	RNA templated ligation
KR102362711B1 (ko)	2017-10-16	2022-02-14	일루미나, 인코포레이티드	변이체 분류를 위한 심층 컨볼루션 신경망
CN110870020B (zh)	2017-10-16	2025-01-10	因美纳有限公司	利用卷积神经网络(cnns)进行异常剪接检测
EP3697932A1 (en)	2017-10-19	2020-08-26	Omniome, Inc.	Simultaneous background reduction and complex stabilization in binding assay workflows
CN118126816A (zh)	2017-11-06	2024-06-04	伊鲁米那股份有限公司	核酸索引化技术
CN110800061B (zh)	2017-11-16	2024-10-11	伊鲁米那股份有限公司	用于确定微卫星不稳定性的系统和方法
EP3733683A4 (en)	2017-11-30	2022-04-06	GeneMind Biosciences Company Limited	NUCLEOSIDE ANALOGUES, METHOD OF MANUFACTURE AND USE
AU2018375785A1 (en)	2017-11-30	2019-12-12	Illumina, Inc.	Validation methods and systems for sequence variant calls
JP6868541B2 (ja) *	2017-12-05	2021-05-12	イルミナケンブリッジリミテッド	修飾ヌクレオシドまたは修飾ヌクレオチド
CN111788633A (zh)	2017-12-29	2020-10-16	诺迪勒思生物科技公司	用于蛋白质鉴定的解码方法
US10752887B2 (en)	2018-01-08	2020-08-25	Dna Script	Variants of terminal deoxynucleotidyl transferase and uses thereof
AU2019205797A1 (en)	2018-01-08	2019-12-19	Illumina, Inc.	Systems and devices for high-throughput sequencing with semiconductor-based detection
WO2019136376A1 (en)	2018-01-08	2019-07-11	Illumina, Inc.	High-throughput sequencing with semiconductor-based detection
CN112105725A (zh)	2018-01-08	2020-12-18	Dna斯克瑞普特公司	末端脱氧核苷酸转移酶的变体及其用途
US11705219B2 (en)	2018-01-15	2023-07-18	Illumina, Inc.	Deep learning-based variant classifier
US10844430B2 (en)	2018-01-24	2020-11-24	Qiagen Sciences, Llc	DNA sequencing reaction additive
US20210371926A1 (en)	2018-01-29	2021-12-02	The Broad Institute, Inc.	Crispr effector system based diagnostics
KR20200139671A (ko)	2018-02-06	2020-12-14	옴니옴 인코포레이티드	핵산 프라이머 연장을 위한 조성물 및 기술
CN111094589A (zh)	2018-02-13	2020-05-01	伊鲁米纳公司	使用水凝胶珠的dna测序
CA3067433C (en)	2018-02-16	2022-11-22	Illumina, Inc.	Charge-tagged nucleotides and methods of use thereof
WO2019164977A1 (en)	2018-02-21	2019-08-29	Singular Genomics Systems, Inc.	Fluorinated nucleotides and uses thereof
CN112218640A (zh)	2018-03-15	2021-01-12	哥伦比亚大学董事会	核苷酸类似物及其在核酸测序和分析中的用途
US12188012B2 (en)	2018-04-02	2025-01-07	Illumina, Inc.	Compositions and methods for making controls for sequence-based genetic testing
US20190318806A1 (en)	2018-04-12	2019-10-17	Illumina, Inc.	Variant Classifier Based on Deep Neural Networks
US20190338352A1 (en)	2018-04-19	2019-11-07	Omniome, Inc.	Accuracy of base calls in nucleic acid sequencing methods
WO2019204229A1 (en)	2018-04-20	2019-10-24	Illumina, Inc.	Methods of encapsulating single cells, the encapsulated cells and uses thereof
US20210189460A1 (en)	2018-04-25	2021-06-24	Qiagen Sciences Llc	Sequential paired-end sequencing
EP3784800B1 (en)	2018-04-26	2023-05-03	Pacific Biosciences of California, Inc.	Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes
WO2019222178A1 (en)	2018-05-14	2019-11-21	Nanostring Technologies, Inc.	Chemical compositions and methods of using same
IL271446B1 (en)	2018-05-15	2024-12-01	Illumina Inc	Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides
IL271454B1 (en)	2018-05-17	2024-12-01	Illumina Inc	High-throughput single-cell sequencing with reduced amplification bias
CN112534063A (zh)	2018-05-22	2021-03-19	安序源有限公司	用于核酸测序的方法、系统和组合物
JP7334122B2 (ja)	2018-05-25	2023-08-28	イルミナインコーポレイテッド	妊娠高血圧腎症に特異的な循環ｒｎａシグネチャー
US11821023B2 (en)	2018-05-30	2023-11-21	Generation Biotech, Llc	Method for capturing long polynucleotides for sequencing specific gnomic regions
JP2021525078A (ja)	2018-05-31	2021-09-24	オムニオムインコーポレイテッドＯｍｎｉｏｍｅ，Ｉｎｃ．	核酸配列決定におけるシグナル対ノイズの増加
US11180794B2 (en)	2018-05-31	2021-11-23	Omniome, Inc.	Methods and compositions for capping nucleic acids
CN111247248A (zh)	2018-06-04	2020-06-05	伊鲁米纳公司	高通量单细胞转录组文库及制备和使用方法
BR112020024790A2 (pt)	2018-06-22	2021-03-02	Quantum-Si Incorporated	fotodetector integrado com região de armazenamento de carga de tempo de detecção variado
CN108822173B (zh) *	2018-06-26	2021-04-02	合肥华纳生物医药科技有限公司	一种荧光标记可剪切核苷酸、合成方法及其在dna测序中的用途
NL2021377B1 (en)	2018-07-03	2020-01-08	Illumina Inc	Interposer with first and second adhesive layers
US12073922B2 (en)	2018-07-11	2024-08-27	Illumina, Inc.	Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors (SSEs)
WO2020020608A1 (en)	2018-07-23	2020-01-30	Dna Script	Massively parallel enzymatic synthesis of nucleic acid strands
CA3107165A1 (en)	2018-07-24	2020-01-30	Omniome, Inc.	Serial formation of ternary complex species
WO2020022891A2 (en)	2018-07-26	2020-01-30	Stichting Vumc	Biomarkers for atrial fibrillation
WO2020028194A1 (en)	2018-07-30	2020-02-06	Readcoor, Inc.	Methods and systems for sample processing or analysis
US12163179B2 (en)	2018-08-03	2024-12-10	10X Gemomics, Inc.	Methods and systems to minimize barcode exchange
KR20210056329A (ko)	2018-08-07	2021-05-18	더 브로드 인스티튜트, 인코퍼레이티드	신규 cas12b 효소 및 시스템
EP3837381A1 (en)	2018-08-15	2021-06-23	Illumina, Inc.	Compositions and methods for improving library enrichment
WO2020039261A1 (en)	2018-08-23	2020-02-27	Boreal Genomics, Inc.	Linked target capture and ligation
US20230323447A1 (en)	2018-08-28	2023-10-12	10X Genomics, Inc.	Method for transposase-mediated spatial tagging and analyzing genomic dna in a biological sample
US11519033B2 (en)	2018-08-28	2022-12-06	10X Genomics, Inc.	Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020047005A1 (en)	2018-08-28	2020-03-05	10X Genomics, Inc.	Resolving spatial arrays
WO2020056044A1 (en)	2018-09-11	2020-03-19	Singular Genomics Systems, Inc.	Modified archaeal family b polymerases
WO2020060811A1 (en)	2018-09-17	2020-03-26	Omniome, Inc.	Engineered polymerases for improved sequencing
EP3853382A4 (en)	2018-09-19	2022-06-22	Apton Biosystems, Inc.	Densely-packed analyte layers and detection methods
CN113195511A (zh) *	2018-09-28	2021-07-30	生捷科技控股公司	二硫键连接的可逆终止剂
US20210396756A1 (en)	2018-10-03	2021-12-23	The Broad Institute, Inc.	Crispr effector system based diagnostics for hemorrhagic fever detection
CN119432989A (zh) *	2018-10-11	2025-02-14	青岛华大智造科技有限责任公司	对多核苷酸进行测序的方法
NZ759665A (en)	2018-10-15	2022-07-01	Illumina Inc	Deep learning-based techniques for pre-training deep convolutional neural networks
US12145960B2 (en)	2018-10-25	2024-11-19	Singular Genomics Systems, Inc.	Nucleotide analogues
AU2019364545A1 (en)	2018-10-26	2021-04-29	Illumina, Inc.	Modulating polymer beads for DNA processing
CA3103719A1 (en)	2018-10-31	2020-05-07	Illumina, Inc.	Polymerases, compositions, and methods of use
SG11202104601PA (en)	2018-11-14	2021-06-29	Dna Script	Terminal deoxynucleotidyl transferase variants and uses thereof
US20240011086A1 (en)	2018-11-15	2024-01-11	Omniome, Inc.	Electronic detection of nucleic acid structure
NL2022043B1 (en)	2018-11-21	2020-06-03	Akershus Univ Hf	Tagmentation-Associated Multiplex PCR Enrichment Sequencing
EP4293126A3 (en)	2018-11-30	2024-01-17	Illumina, Inc.	Analysis of multiple analytes using a single assay
US10710076B2 (en)	2018-12-04	2020-07-14	Omniome, Inc.	Mixed-phase fluids for nucleic acid sequencing and other analytical assays
CN112654718A (zh)	2018-12-05	2021-04-13	伊卢米纳剑桥有限公司	通过桥式扩增进行簇生成的方法和组合物
CA3103739A1 (en)	2018-12-05	2020-06-11	Illumina, Inc.	Polymerases, compositions, and methods of use
US20220025447A1 (en)	2018-12-10	2022-01-27	10X Genomics, Inc.	Generating spatial arrays with gradients
GB201820300D0 (en)	2018-12-13	2019-01-30	10X Genomics Inc	Method for spatial tagging and analysing genomic DNA in a biological specimen
SG11202105441WA (en)	2018-12-13	2021-06-29	Dna Script	Direct oligonucleotide synthesis on cells and biomolecules
GB201820341D0 (en)	2018-12-13	2019-01-30	10X Genomics Inc	Method for transposase-mediated spatial tagging and analysing genomic DNA in a biological specimen
CN112639126A (zh)	2018-12-14	2021-04-09	伊卢米纳剑桥有限公司	降低测序期间用未标记的核苷酸的定相
AU2019411267A1 (en)	2018-12-17	2021-01-07	Illumina Cambridge Limited	Primer oligonucleotide for sequencing
JP7296409B2 (ja)	2018-12-17	2023-06-22	イルミナケンブリッジリミテッド	ポリヌクレオチドシーケンシングに使用するための組成物
KR20210104554A (ko)	2018-12-18	2021-08-25	일루미나 케임브리지 리미티드	단일 표면 프라이머를 사용하는 페어드 엔드 서열분석을 위한 방법 및 조성물
FI3899037T3 (fi)	2018-12-19	2023-11-21	Illumina Inc	Menetelmiä polynukleotidiklusterin klonaalisuusprioriteetin parantamiseksi
US11041199B2 (en)	2018-12-20	2021-06-22	Omniome, Inc.	Temperature control for analysis of nucleic acids and other analytes
US11293061B2 (en)	2018-12-26	2022-04-05	Illumina Cambridge Limited	Sequencing methods using nucleotides with 3′ AOM blocking group
JP7548588B2 (ja)	2019-01-02	2024-09-10	ラディアクションリミテッド	放射線保護装置およびそのための材料
US12011306B2 (en)	2019-01-02	2024-06-18	Radiaction Ltd	Patient head protection device
WO2020141143A1 (en)	2019-01-03	2020-07-09	Dna Script	One pot synthesis of sets of oligonucleotides
EP3884071B1 (en)	2019-01-03	2025-03-26	Ncan Genomics, Inc.	Linked target capture
US11649485B2 (en)	2019-01-06	2023-05-16	10X Genomics, Inc.	Generating capture probes for spatial analysis
US11926867B2 (en)	2019-01-06	2024-03-12	10X Genomics, Inc.	Generating capture probes for spatial analysis
JP2022516684A (ja) *	2019-01-08	2022-03-01	シンギュラー・ゲノミクス・システムズ・インコーポレイテッド	ヌクレオチドの開裂可能なリンカーおよびその使用
US11685946B2 (en)	2019-01-11	2023-06-27	Illumina Cambridge Limited	Complex surface-bound transposome complexes
CA3127102A1 (en)	2019-01-23	2020-07-30	Quantum-Si Incorporated	High intensity labeled reactant compositions and methods for sequencing
EP3921418A4 (en)	2019-02-06	2023-02-08	Singular Genomics Systems, Inc.	NUCLEIC ACID SEQUENCING COMPOSITIONS AND METHODS
SG11202107921SA (en)	2019-02-12	2021-08-30	Dna Script	Efficient product cleavage in template-free enzymatic synthesis of polynucleotides.
WO2020167574A1 (en)	2019-02-14	2020-08-20	Omniome, Inc.	Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
JP2022521730A (ja)	2019-02-19	2022-04-12	ウルティマ・ゲノミクス・インコーポレーテッド	光検出および配列決定のためのリンカーおよび方法
US11680950B2 (en)	2019-02-20	2023-06-20	Pacific Biosciences Of California, Inc.	Scanning apparatus and methods for detecting chemical and biological analytes
EP3931354A1 (en)	2019-02-28	2022-01-05	10X Genomics, Inc.	Profiling of biological analytes with spatially barcoded oligonucleotide arrays
SG11202102530QA (en)	2019-03-01	2021-04-29	Illumina Inc	High-throughput single-nuclei and single-cell libraries and methods of making and of using
EP3938538A1 (en)	2019-03-15	2022-01-19	10X Genomics, Inc.	Methods for using spatial arrays for single cell sequencing
US11210554B2 (en)	2019-03-21	2021-12-28	Illumina, Inc.	Artificial intelligence-based generation of sequencing metadata
NL2023312B1 (en)	2019-03-21	2020-09-28	Illumina Inc	Artificial intelligence-based base calling
NL2023310B1 (en)	2019-03-21	2020-09-28	Illumina Inc	Training data generation for artificial intelligence-based sequencing
NL2023314B1 (en)	2019-03-21	2020-09-28	Illumina Inc	Artificial intelligence-based quality scoring
WO2020191390A2 (en)	2019-03-21	2020-09-24	Illumina, Inc.	Artificial intelligence-based quality scoring
NL2023316B1 (en)	2019-03-21	2020-09-28	Illumina Inc	Artificial intelligence-based sequencing
NL2023311B9 (en)	2019-03-21	2021-03-12	Illumina Inc	Artificial intelligence-based generation of sequencing metadata
US11676685B2 (en)	2019-03-21	2023-06-13	Illumina, Inc.	Artificial intelligence-based quality scoring
EP3887542A1 (en)	2019-03-22	2021-10-06	10X Genomics, Inc.	Three-dimensional spatial analysis
US11579217B2 (en)	2019-04-12	2023-02-14	Western Digital Technologies, Inc.	Devices and methods for frequency- and phase-based detection of magnetically-labeled molecules using spin torque oscillator (STO) sensors
US11738336B2 (en)	2019-04-12	2023-08-29	Western Digital Technologies, Inc.	Spin torque oscillator (STO) sensors used in nucleic acid sequencing arrays and detection schemes for nucleic acid sequencing
US11609208B2 (en)	2019-04-12	2023-03-21	Western Digital Technologies, Inc.	Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles
US11327073B2 (en)	2019-04-12	2022-05-10	Western Digital Technologies, Inc.	Thermal sensor array for molecule detection and related detection schemes
US11112468B2 (en)	2019-04-12	2021-09-07	Western Digital Technologies, Inc.	Magnetoresistive sensor array for molecule detection and related detection schemes
US12121896B2 (en)	2019-04-12	2024-10-22	Roche Sequencing Solutions, Inc.	Nucleic acid sequencing by synthesis using magnetic sensor arrays
US11593649B2 (en)	2019-05-16	2023-02-28	Illumina, Inc.	Base calling using convolutions
US11423306B2 (en)	2019-05-16	2022-08-23	Illumina, Inc.	Systems and devices for characterization and performance analysis of pixel-based sequencing
WO2020243579A1 (en)	2019-05-30	2020-12-03	10X Genomics, Inc.	Methods of detecting spatial heterogeneity of a biological sample
US11644406B2 (en)	2019-06-11	2023-05-09	Pacific Biosciences Of California, Inc.	Calibrated focus sensing
KR20220059467A (ko)	2019-07-02	2022-05-10	레디액션 엘티디.	전개형 방사선 차폐부 커버
US20220154173A1 (en)	2019-07-12	2022-05-19	Iiiumina Cambridge Limited	Compositions and Methods for Preparing Nucleic Acid Sequencing Libraries Using CRISPR/CAS9 Immobilized on a Solid Support
CN113226519B (zh)	2019-07-12	2024-10-01	Illumina剑桥有限公司	使用电泳制备核酸文库
US11377655B2 (en)	2019-07-16	2022-07-05	Pacific Biosciences Of California, Inc.	Synthetic nucleic acids having non-natural structures
US10656368B1 (en)	2019-07-24	2020-05-19	Omniome, Inc.	Method and system for biological imaging using a wide field objective lens
WO2021018919A1 (en)	2019-07-30	2021-02-04	Dna Script	Template-free enzymatic synthesis of polynucleotides using poly(a) and poly(u) polymerases
CA3145912A1 (en)	2019-08-01	2021-02-04	Adrian Horgan	Increasing long-sequence yields in template-free enzymatic synthesis of polynucleotides.
CN114286867B (zh) *	2019-08-20	2024-04-16	青岛华大智造科技有限责任公司	一种基于发光标记物光信号动力学及二次发光信号对多核苷酸进行测序的方法
WO2021048142A1 (en)	2019-09-09	2021-03-18	Dna Script	Template-free enzymatic polynucleotide synthesis using photocleavable linkages
US11180520B2 (en)	2019-09-10	2021-11-23	Omniome, Inc.	Reversible modifications of nucleotides
US20220290245A1 (en)	2019-09-11	2022-09-15	The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic	Cancer detection and classification
US11512295B2 (en)	2019-09-12	2022-11-29	Singular Genomics Systems, Inc.	Modified thermoccocus polymerases
US11208682B2 (en)	2019-09-13	2021-12-28	Western Digital Technologies, Inc.	Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
US20220403436A1 (en)	2019-09-23	2022-12-22	Dna Script	Increasing Long-Sequence Yields in Template-Free Enzymatic Synthesis of Polynucleotides
US11287422B2 (en)	2019-09-23	2022-03-29	Element Biosciences, Inc.	Multivalent binding composition for nucleic acid analysis
US11514575B2 (en)	2019-10-01	2022-11-29	10X Genomics, Inc.	Systems and methods for identifying morphological patterns in tissue samples
CN114599795A (zh)	2019-10-18	2022-06-07	加利福尼亚太平洋生物科学股份有限公司	用于对核酸加帽的方法和组合物
WO2021091611A1 (en)	2019-11-08	2021-05-14	10X Genomics, Inc.	Spatially-tagged analyte capture agents for analyte multiplexing
US20210139867A1 (en)	2019-11-08	2021-05-13	Omniome, Inc.	Engineered polymerases for improved sequencing by binding
EP4025711A2 (en)	2019-11-08	2022-07-13	10X Genomics, Inc.	Enhancing specificity of analyte binding
US20220411840A1 (en)	2019-11-13	2022-12-29	Dna Script	High Efficiency Template-Free Enzymatic Synthesis of Polynucleotides
US12154266B2 (en)	2019-11-18	2024-11-26	10X Genomics, Inc.	Systems and methods for binary tissue classification
AU2020388573A1 (en)	2019-11-21	2022-06-23	10X Genomics, Inc,	Spatial analysis of analytes
US11747329B2 (en)	2019-11-22	2023-09-05	Western Digital Technologies, Inc.	Magnetic gradient concentrator/reluctance detector for molecule detection
CA3131748A1 (en)	2019-11-22	2021-05-27	Sarah E. SHULTZABERGER	Circulating rna signatures specific to preeclampsia
DE202019106694U1 (de)	2019-12-02	2020-03-19	Omniome, Inc.	System zur Sequenzierung von Nukleinsäuren in Fluidschaum
DE202019106695U1 (de)	2019-12-02	2020-03-19	Omniome, Inc.	System zur Sequenzierung von Nukleinsäuren in Fluidschaum
WO2021113287A1 (en)	2019-12-04	2021-06-10	Illumina, Inc.	Preparation of dna sequencing libraries for detection of dna pathogens in plasma
WO2021118349A1 (en)	2019-12-10	2021-06-17	Prinses Máxima Centrum Voor Kinderoncologie B.V.	Methods of typing germ cell tumors
EP4073240A1 (en)	2019-12-12	2022-10-19	DNA Script	Chimeric terminal deoxynucleotidyl transferases for template-free enzymatic synthesis of polynucleotides
EP4077703A1 (en)	2019-12-16	2022-10-26	DNA Script	Template-free enzymatic polynucleotide synthesis using dismutationless terminal deoxynucleotidyl transferase variants
KR20220111315A (ko) *	2019-12-18	2022-08-09	에프. 호프만-라 로슈 아게	연속 표지화 방식을 사용하는 합성에 의한 시퀀싱 방법
AU2020407641A1 (en)	2019-12-19	2021-09-23	Illumina, Inc.	High-throughput single-cell libraries and methods of making and of using
US11498078B2 (en)	2019-12-23	2022-11-15	Singular Genomics Systems, Inc.	Flow cell receiver and methods of use
WO2021133849A1 (en)	2019-12-23	2021-07-01	10X Genomics, Inc.	Methods for spatial analysis using rna-templated ligation
CN115038794A (zh)	2019-12-23	2022-09-09	10X基因组学有限公司	在基于分区的测定中使用固定生物样品的组合物和方法
EP4081653B1 (en)	2019-12-23	2024-07-03	Singular Genomics Systems, Inc.	Methods for long read sequencing
US11747262B2 (en)	2019-12-23	2023-09-05	Singular Genomics Systems, Inc.	Flow cell carrier and methods of use
AU2020416718A1 (en)	2019-12-31	2022-07-07	Singular Genomics Systems, Inc.	Polynucleotide barcodes for long read sequencing
US11732299B2 (en)	2020-01-21	2023-08-22	10X Genomics, Inc.	Spatial assays with perturbed cells
US11702693B2 (en)	2020-01-21	2023-07-18	10X Genomics, Inc.	Methods for printing cells and generating arrays of barcoded cells
US11821035B1 (en)	2020-01-29	2023-11-21	10X Genomics, Inc.	Compositions and methods of making gene expression libraries
CN115362264A (zh)	2020-01-29	2022-11-18	10X基因组学有限公司	用于分析物检测的组合物和方法
US12076701B2 (en)	2020-01-31	2024-09-03	10X Genomics, Inc.	Capturing oligonucleotides in spatial transcriptomics
US11898205B2 (en)	2020-02-03	2024-02-13	10X Genomics, Inc.	Increasing capture efficiency of spatial assays
US12110541B2 (en)	2020-02-03	2024-10-08	10X Genomics, Inc.	Methods for preparing high-resolution spatial arrays
US12110548B2 (en)	2020-02-03	2024-10-08	10X Genomics, Inc.	Bi-directional in situ analysis
US20230054204A1 (en)	2020-02-04	2023-02-23	Pacific Biosciences Of California, Inc.	Flow cells and methods for their manufacture and use
US12112833B2 (en)	2020-02-04	2024-10-08	10X Genomics, Inc.	Systems and methods for index hopping filtering
US11732300B2 (en)	2020-02-05	2023-08-22	10X Genomics, Inc.	Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (en)	2020-02-07	2021-08-12	10X Genomics, Inc.	Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US11835462B2 (en)	2020-02-11	2023-12-05	10X Genomics, Inc.	Methods and compositions for partitioning a biological sample
EP4107284A1 (en)	2020-02-17	2022-12-28	10X Genomics, Inc.	In situ analysis of chromatin interaction
US11807851B1 (en)	2020-02-18	2023-11-07	Ultima Genomics, Inc.	Modified polynucleotides and uses thereof
US20210265018A1 (en)	2020-02-20	2021-08-26	Illumina, Inc.	Knowledge Distillation and Gradient Pruning-Based Compression of Artificial Intelligence-Based Base Caller
US20210265016A1 (en)	2020-02-20	2021-08-26	Illumina, Inc.	Data Compression for Artificial Intelligence-Based Base Calling
AU2021224871A1 (en)	2020-02-20	2022-09-08	Illumina, Inc.	Artificial intelligence-based many-to-many base calling
US20210265015A1 (en)	2020-02-20	2021-08-26	Illumina, Inc.	Hardware Execution and Acceleration of Artificial Intelligence-Based Base Caller
JP2023514749A (ja)	2020-02-21	2023-04-07	１０エックスジェノミクスインコーポレイテッド	統合型インサイチュ空間的アッセイのための方法および組成物
EP4106913A1 (en)	2020-02-21	2022-12-28	10X Genomics, Inc.	Compositions, methods and systems for sample processing
US11891654B2 (en)	2020-02-24	2024-02-06	10X Genomics, Inc.	Methods of making gene expression libraries
CN115151652B (zh)	2020-02-25	2025-02-07	Dna斯克瑞普特公司	用于酶促合成多核苷酸的方法和设备
US11034942B1 (en)	2020-02-27	2021-06-15	Singular Genomics Systems, Inc.	Modified pyrococcus polymerases and uses thereof
US11926863B1 (en)	2020-02-27	2024-03-12	10X Genomics, Inc.	Solid state single cell method for analyzing fixed biological cells
AU2021230282A1 (en)	2020-03-03	2022-09-22	Pacific Biosciences Of California, Inc.	Methods and compositions for sequencing double stranded nucleic acids
US11768175B1 (en)	2020-03-04	2023-09-26	10X Genomics, Inc.	Electrophoretic methods for spatial analysis
US12188085B2 (en)	2020-03-05	2025-01-07	10X Genomics, Inc.	Three-dimensional spatial transcriptomics with sequencing readout
WO2021178893A2 (en)	2020-03-06	2021-09-10	Singular Genomics Systems, Inc.	Linked paired strand sequencing
JP2023516491A (ja)	2020-03-10	2023-04-19	エフ．ホフマン－ラロシュアーゲー	核酸配列決定のための磁気センサアレイならびにそれらの製造方法および使用方法
AU2021249046A1 (en)	2020-03-30	2022-10-20	Illumina, Inc.	Methods and compositions for preparing nucleic acid libraries
WO2021213903A1 (en)	2020-04-20	2021-10-28	Dna Script	Terminal deoxynucleotidyl transferase variants and uses thereof
CN115551639A (zh) *	2020-04-21	2022-12-30	赫孚孟拉罗股份公司	具有单分子传感器阵列的高通量核酸定序
WO2021216708A1 (en)	2020-04-22	2021-10-28	10X Genomics, Inc.	Methods for spatial analysis using targeted rna depletion
WO2021216998A1 (en)	2020-04-24	2021-10-28	Singular Genomics Systems, Inc.	Modified nucleotides and uses thereof
WO2021221500A1 (en)	2020-04-27	2021-11-04	Agendia N.V.	Treatment of her2 negative, mammaprint high risk 2 breast cancer.
US11188778B1 (en)	2020-05-05	2021-11-30	Illumina, Inc.	Equalization-based image processing and spatial crosstalk attenuator
CN115836135A (zh)	2020-05-05	2023-03-21	加利福尼亚太平洋生物科学股份有限公司	用于修饰聚合酶-核酸复合物的组合物和方法
US20230203592A1 (en)	2020-05-05	2023-06-29	Akershus Universitetssykehus Hf	Compositions and methods for characterizing bowel cancer
CA3174298A1 (en)	2020-05-08	2021-11-11	Sven BILKE	Genome sequencing and detection techniques
CN115916967A (zh)	2020-05-12	2023-04-04	伊鲁米纳公司	使用重组末端脱氧核苷酸转移酶生成具有经修饰的碱基的核酸
WO2021237087A1 (en)	2020-05-22	2021-11-25	10X Genomics, Inc.	Spatial analysis to detect sequence variants
ES2989052T3 (es)	2020-05-22	2024-11-25	10X Genomics Inc	Medición espacio-temporal simultánea de la expresión génica y la actividad celular
WO2021242834A1 (en)	2020-05-26	2021-12-02	10X Genomics, Inc.	Method for resetting an array
EP4158054A1 (en)	2020-06-02	2023-04-05	10X Genomics, Inc.	Spatial transcriptomics for antigen-receptors
EP4025692A2 (en)	2020-06-02	2022-07-13	10X Genomics, Inc.	Nucleic acid library methods
US12031177B1 (en)	2020-06-04	2024-07-09	10X Genomics, Inc.	Methods of enhancing spatial resolution of transcripts
US20230193356A1 (en)	2020-06-08	2023-06-22	The Broad Institute, Inc.	Single cell combinatorial indexing from amplified nucleic acids
ES2981265T3 (es)	2020-06-08	2024-10-08	10X Genomics Inc	Métodos para determinar un margen quirúrgico y métodos de uso del mismo
WO2021252617A1 (en)	2020-06-09	2021-12-16	Illumina, Inc.	Methods for increasing yield of sequencing libraries
ES2999535T3 (en)	2020-06-10	2025-02-26	10X Genomics Inc	Methods for determining a location of an analyte in a biological sample
CA3182266A1 (en)	2020-06-11	2021-12-16	Vadim Lobanov	Methods and systems for computational decoding of biological, chemical, and physical entities
US12209273B2 (en)	2020-06-12	2025-01-28	10X Genomics, Inc.	Nucleic acid assays using click chemistry bioconjugation
WO2021254934A1 (en)	2020-06-16	2021-12-23	Dna Script	Systems, apparatus and kits for enzymatic polynucleotide synthesis
BR112022026056A2 (pt)	2020-06-22	2023-03-07	Illumina Cambridge Ltd	Nucleosídeos e nucleotídeos com grupo bloqueador 3? acetal
CN116034166A (zh)	2020-06-25	2023-04-28	10X基因组学有限公司	Dna甲基化的空间分析
JP2023532231A (ja)	2020-06-30	2023-07-27	イルミナインコーポレイテッド	傷なしｄｎａを生成するための触媒的に制御された合成による配列決定
WO2022006495A1 (en)	2020-07-02	2022-01-06	Illumina, Inc.	A method to calibrate nucleic acid library seeding efficiency in flowcells
US12168801B1 (en)	2020-07-02	2024-12-17	10X Genomics, Inc.	Hybrid/capture probe designs for full-length cDNA
US11761038B1 (en)	2020-07-06	2023-09-19	10X Genomics, Inc.	Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en)	2020-07-06	2025-01-28	10X Genomics, Inc.	Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981960B1 (en)	2020-07-06	2024-05-14	10X Genomics, Inc.	Spatial analysis utilizing degradable hydrogels
CN116018412A (zh)	2020-07-08	2023-04-25	Illumina公司	作为转座体载体的小珠
EP4153606A4 (en)	2020-07-13	2024-10-02	Singular Genomics Systems, Inc.	METHODS FOR SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES
US20230313255A1 (en)	2020-07-15	2023-10-05	Dna Script	Massively Parallel Enzymatic Synthesis of Polynucleotides
US11981964B2 (en) *	2020-07-28	2024-05-14	Illumina Cambridge Limited	Substituted coumarin dyes and uses as fluorescent labels
MX2023000872A (es)	2020-08-06	2023-02-22	Illumina Inc	Preparacion de genotecas de secuenciacion de arn y adn usando transposomas enlazados por globulos.
US20220049303A1 (en)	2020-08-17	2022-02-17	Readcoor, Llc	Methods and systems for spatial mapping of genetic variants
CN116323971A (zh)	2020-08-18	2023-06-23	Illumina公司	核酸的序列特异性靶向转座和选择以及分选
US11981958B1 (en)	2020-08-20	2024-05-14	10X Genomics, Inc.	Methods for spatial analysis using DNA capture
US20220067489A1 (en)	2020-08-28	2022-03-03	Illumina, Inc.	Detecting and Filtering Clusters Based on Artificial Intelligence-Predicted Base Calls
US11200446B1 (en)	2020-08-31	2021-12-14	Element Biosciences, Inc.	Single-pass primary analysis
CA3188197A1 (en)	2020-09-11	2022-03-17	Andrew Slatter	Methods of enriching a target sequence from a sequencing library using hairpin adaptors
WO2022056385A1 (en)	2020-09-14	2022-03-17	Singular Genomics Systems, Inc.	Methods and systems for multidimensional imaging
AU2021345283B2 (en)	2020-09-18	2024-12-19	10X Genomics, Inc.	Sample handling apparatus and image registration methods
WO2022063835A1 (en)	2020-09-22	2022-03-31	Dna Script	Stabilized n-terminally truncated terminal deoxynucleotidyl transferase variants and uses thereof
US11926822B1 (en)	2020-09-23	2024-03-12	10X Genomics, Inc.	Three-dimensional spatial analysis
IL302207A (en)	2020-10-21	2023-06-01	Illumina Inc	Sequencing templates comprising multiple inserts and compositions and methods for improving sequencing throughput
WO2022087485A1 (en)	2020-10-22	2022-04-28	Singular Genomics Systems, Inc.	Nucleic acid circularization and amplification on a surface
WO2022090323A1 (en)	2020-10-29	2022-05-05	Dna Script	Enzymatic synthesis of polynucleotide probes
US12031179B2 (en)	2020-10-30	2024-07-09	Singular Genomics Systems, Inc.	Methods and compositions for reducing nucleotide impurities
US12071667B2 (en)	2020-11-04	2024-08-27	10X Genomics, Inc.	Sequence analysis using meta-stable nucleic acid molecules
US20220145345A1 (en)	2020-11-11	2022-05-12	Microsoft Technology Licensing, Llc	Spatial control of polynucleotide synthesis by strand capping
US11827935B1 (en)	2020-11-19	2023-11-28	10X Genomics, Inc.	Methods for spatial analysis using rolling circle amplification and detection probes
EP4239335A4 (en) *	2020-12-01	2024-09-25	Kyushu University, National University Corporation	Biomolecule structure detection probe, biomolecule structure detection kit, and method for detecting biomolecule structure
CA3179883A1 (en)	2020-12-02	2022-06-09	Illumina Software, Inc.	System and method for detection of genetic alterations
US20220186300A1 (en)	2020-12-11	2022-06-16	10X Genomics, Inc.	Methods and compositions for multimodal in situ analysis
EP4264231A4 (en)	2020-12-16	2024-11-13	Singular Genomics Systems, Inc.	Kinematic imaging system
EP4153964A4 (en)	2020-12-21	2023-11-29	Singular Genomics Systems, Inc.	MULTICOLOR IMAGING SYSTEMS AND METHODS
WO2022140028A1 (en)	2020-12-21	2022-06-30	10X Genomics, Inc.	Methods, compositions, and systems for capturing probes and/or barcodes
AU2022208683A1 (en)	2021-01-13	2023-08-03	Pacific Biosciences Of California, Inc.	Surface structuring with colloidal assembly
US12060603B2 (en)	2021-01-19	2024-08-13	10X Genomics, Inc.	Methods for internally controlled in situ assays using padlock probes
EP4488385A3 (en)	2021-01-26	2025-02-19	10x Genomics, Inc.	Nucleic acid analog probes for in situ analysis
US20240117416A1 (en)	2021-01-29	2024-04-11	Illumina, Inc.	Methods, compositions and kits to improve seeding efficiency of flow cells with polynucleotides
EP4288562B1 (en)	2021-02-04	2024-11-20	Illumina, Inc.	Long indexed-linked read generation on transposome bound beads
US11486001B2 (en)	2021-02-08	2022-11-01	Singular Genomics Systems, Inc.	Methods and compositions for sequencing complementary polynucleotides
WO2022174054A1 (en)	2021-02-13	2022-08-18	The General Hospital Corporation	Methods and compositions for in situ macromolecule detection and uses thereof
ES2989523T3 (es)	2021-02-19	2024-11-26	10X Genomics Inc	Método de uso de un dispositivo modular de soporte para ensayos
US20220282319A1 (en)	2021-03-03	2022-09-08	10X Genomics, Inc.	Analyte detection in situ using nucleic acid origami
US11884977B2 (en)	2021-03-12	2024-01-30	Singular Genomics Systems, Inc.	Nanoarrays and methods of use thereof
EP4263868A4 (en)	2021-03-12	2024-11-27	Singular Genomics Systems, Inc.	NANONETWORKS AND METHODS OF USE THEREOF
WO2022197752A1 (en)	2021-03-16	2022-09-22	Illumina, Inc.	Tile location and/or cycle based weight set selection for base calling
WO2022198068A1 (en)	2021-03-18	2022-09-22	10X Genomics, Inc.	Multiplex capture of gene and protein expression from a biological sample
AU2022245985A1 (en)	2021-03-22	2023-09-21	Illumina Cambridge Limited	Methods for improving nucleic acid cluster clonality
CA3214278A1 (en)	2021-03-29	2022-10-06	Illumina, Inc	Improved methods of library preparation
KR20230163434A (ko)	2021-03-29	2023-11-30	일루미나, 인코포레이티드	라이브러리에서 dna 손상을 평가하고 앰플리콘 크기 바이어스를 정규화하기 위한 조성물 및 방법
EP4314282A1 (en)	2021-03-30	2024-02-07	Illumina, Inc.	Improved methods of isothermal complementary dna and library preparation
MX2023011660A (es)	2021-03-31	2023-12-11	Illumina Cambridge Ltd	Tecnicas de secuenciacion de genoteca de acido nucleico con deteccion de dimero adaptador.
CA3183578A1 (en)	2021-03-31	2022-10-06	Illumina Inc.	Artificial intelligence-based base caller with contextual awareness
IL307164A (en)	2021-03-31	2023-11-01	Illumina Inc	Methods for preparing sequence libraries for directional labeling using transposon-based technology with unique molecular identifiers for error correction
WO2022213027A1 (en)	2021-04-02	2022-10-06	Illumina, Inc.	Machine-learning model for detecting a bubble within a nucleotide-sample slide for sequencing
WO2022207934A1 (en)	2021-04-02	2022-10-06	Dna Script	Methods and kits for enzymatic synthesis of g4-prone polynucleotides
WO2022221425A1 (en)	2021-04-14	2022-10-20	10X Genomics, Inc.	Methods of measuring mislocalization of an analyte
US12217829B2 (en)	2021-04-15	2025-02-04	Illumina, Inc.	Artificial intelligence-based analysis of protein three-dimensional (3D) structures
FR3121936A1 (fr)	2021-04-20	2022-10-21	Naos Institute Of Life Science	Methode de criblage d’ingredients et de compositions topiques ecobiologiques, et son utilisation pour realiser un soin cosmetique de restauration du microbiote cutane
US12070744B2 (en)	2021-04-22	2024-08-27	Illumina, Inc.	Valve assemblies and related systems
US11578320B2 (en)	2021-04-27	2023-02-14	Singular Genomics Systems, Inc.	High density sequencing and multiplexed priming
CN117377775A (zh)	2021-04-29	2024-01-09	因美纳有限公司	用于核酸表征的扩增技术
WO2022235764A1 (en)	2021-05-05	2022-11-10	Singular Genomics Systems, Inc.	Multiomic analysis device and methods of use thereof
WO2022235163A1 (en)	2021-05-07	2022-11-10	Agendia N.V.	Endocrine treatment of hormone receptor positive breast cancer typed as having a low risk of recurrence
US20220356515A1 (en)	2021-05-10	2022-11-10	Pacific Biosciences Of California, Inc.	Dna amplification buffer replenishment during rolling circle amplification
EP4337786A1 (en)	2021-05-10	2024-03-20	Pacific Biosciences of California, Inc.	Single-molecule seeding and amplification on a surface
MX2023012659A (es)	2021-05-20	2023-12-07	Illumina Inc	Composiciones y metodos para secuenciación por síntesis.
WO2022251510A2 (en)	2021-05-28	2022-12-01	Illumina, Inc.	Oligo-modified nucleotide analogues for nucleic acid preparation
CN117396613A (zh)	2021-06-01	2024-01-12	10X基因组学有限公司	用于分析物检测和探针解析的方法和组合物
CN117751197A (zh)	2021-06-02	2024-03-22	10X基因组学有限公司	使用不对称可环化探针的样品分析
WO2022256503A1 (en)	2021-06-03	2022-12-08	10X Genomics, Inc.	Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
US20220403450A1 (en)	2021-06-03	2022-12-22	Illumina Software, Inc.	Systems and methods for sequencing nucleotides using two optical channels
CN117677435A (zh)	2021-06-15	2024-03-08	伊鲁米纳公司	用于测序的不含水凝胶的表面官能化
US11859241B2 (en)	2021-06-17	2024-01-02	Element Biosciences, Inc.	Compositions and methods for pairwise sequencing
US11535892B1 (en)	2021-06-17	2022-12-27	Element Biosciences, Inc.	Compositions and methods for pairwise sequencing
CA3223112A1 (en)	2021-06-18	2022-12-22	Mark AMBROSO	Engineered polymerases
CN117597453A (zh)	2021-06-23	2024-02-23	伊鲁米纳公司	用于测序试剂的组合物、方法、试剂盒、料筒和系统
JP2024527307A (ja)	2021-06-29	2024-07-24	イルミナインコーポレイテッド	ヌクレオチド塩基コール及び塩基コール品質を決定するための信号対雑音比メトリック
JP2024529836A (ja)	2021-06-29	2024-08-14	イルミナインコーポレイテッド	ゲノム座標の確信度分類を生成するための機械学習モデル
WO2023278609A1 (en)	2021-06-29	2023-01-05	Illumina, Inc.	Self-learned base caller, trained using organism sequences
WO2023278184A1 (en)	2021-06-29	2023-01-05	Illumina, Inc.	Methods and systems to correct crosstalk in illumination emitted from reaction sites
US20230005253A1 (en)	2021-07-01	2023-01-05	Illumina, Inc.	Efficient artificial intelligence-based base calling of index sequences
US20230027409A1 (en)	2021-07-13	2023-01-26	Illumina, Inc.	Methods and systems for real time extraction of crosstalk in illumination emitted from reaction sites
CN117651855A (zh)	2021-07-13	2024-03-05	10X基因组学有限公司	用于制备具有可控厚度的聚合基质的方法
US11455487B1 (en)	2021-10-26	2022-09-27	Illumina Software, Inc.	Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
JP2024532004A (ja)	2021-07-19	2024-09-04	イルミナインコーポレイテッド	ベースコールのための補間及び適合による強度抽出
US20230021577A1 (en)	2021-07-23	2023-01-26	Illumina Software, Inc.	Machine-learning model for recalibrating nucleotide-base calls
WO2023004357A1 (en)	2021-07-23	2023-01-26	Illumina, Inc.	Methods for preparing substrate surface for dna sequencing
IL309786A (en)	2021-07-28	2024-02-01	Illumina Inc	Quality score calibration of BASECALLING systems
EP4450640A3 (en)	2021-07-30	2024-11-27	10x Genomics, Inc.	Methods and compositions for synchronizing reactions in situ
US12139751B2 (en)	2021-07-30	2024-11-12	10X Genomics, Inc.	Circularizable probes for in situ analysis
WO2023014741A1 (en)	2021-08-03	2023-02-09	Illumina Software, Inc.	Base calling using multiple base caller models
CN118043476A (zh)	2021-08-03	2024-05-14	10X基因组学有限公司	核酸多联体及其稳定和/或压缩方法
US12077789B2 (en)	2021-08-14	2024-09-03	Illumina, Inc.	Polymerases, compositions, and methods of use
WO2023023484A1 (en)	2021-08-16	2023-02-23	10X Genomics, Inc.	Probes comprising a split barcode region and methods of use
CN117881795A (zh)	2021-08-17	2024-04-12	因美纳有限公司	用于鉴定甲基化胞嘧啶的方法和组合物
WO2023034076A1 (en)	2021-08-31	2023-03-09	Illumina, Inc.	Flow cell with enhanced well imaging resolution
EP4509614A2 (en)	2021-09-01	2025-02-19	10X Genomics, Inc.	Methods, compositions, and kits for blocking a capture probe on a spatial array
CN117580961A (zh)	2021-09-01	2024-02-20	Illumina公司	用于加速碱基判读的幅度调制
EP4396372A2 (en)	2021-09-03	2024-07-10	Singular Genomics Systems, Inc.	Amplification oligonucleotides
WO2023044229A1 (en)	2021-09-17	2023-03-23	Illumina, Inc.	Automatically identifying failure sources in nucleotide sequencing from base-call-error patterns
US20230095961A1 (en)	2021-09-21	2023-03-30	Illumina, Inc.	Graph reference genome and base-calling approach using imputed haplotypes
WO2023049212A2 (en)	2021-09-22	2023-03-30	Illumina, Inc.	State-based base calling
CN118318049A (zh)	2021-09-28	2024-07-09	安序源有限公司	用于处理核酸样品的方法以及核酸样品的组合物
WO2023056328A2 (en)	2021-09-30	2023-04-06	Illumina, Inc.	Solid supports and methods for depleting and/or enriching library fragments prepared from biosamples
US20230096386A1 (en)	2021-09-30	2023-03-30	Illumina Cambridge Limited	Polynucleotide sequencing
KR20240074839A (ko)	2021-10-11	2024-05-28	노틸러스 서브시디어리, 인크.	단백질 및 프로테옴의 고도로 다중화 가능한 분석
AU2022371198A1 (en)	2021-10-20	2024-05-02	Illumina, Inc.	Methods for capturing library dna for sequencing
EP4423664A1 (en)	2021-10-25	2024-09-04	Singular Genomics Systems, Inc.	Manipulating and detecting biological samples
EP4422792A1 (en)	2021-10-26	2024-09-04	Singular Genomics Systems, Inc.	Multiplexed targeted amplification of polynucleotides
WO2023081485A1 (en)	2021-11-08	2023-05-11	Pacific Biosciences Of California, Inc.	Stepwise sequencing of a polynucleotide with a homogenous reaction mixture
EP4430176A2 (en)	2021-11-10	2024-09-18	DNA Script	Novel terminal deoxynucleotidyl transferase (tdt) variants
AU2022388772A1 (en)	2021-11-10	2024-05-16	Dna Script	Novel terminal deoxynucleotidyl
WO2023085932A1 (en)	2021-11-10	2023-05-19	Omnigen B.V.	Prediction of response following folfirinox treatment in cancer patients
EP4305195A2 (en)	2021-12-01	2024-01-17	10X Genomics, Inc.	Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
JP2024543762A (ja)	2021-12-02	2024-11-26	イルミナインコーポレイテッド	ヌクレオチド塩基コールを決定するためのクラスタ固有シグナル補正の生成
US20230183799A1 (en)	2021-12-10	2023-06-15	Illumina, Inc.	Parallel sample and index sequencing
WO2023122033A1 (en)	2021-12-20	2023-06-29	10X Genomics, Inc.	Self-test for pathology/histology slide imaging device
US20230193147A1 (en)	2021-12-21	2023-06-22	Illumina Cambridge Limited	Wax-microsphere matrix compositions and methods of making and using the same
WO2023122363A1 (en)	2021-12-23	2023-06-29	Illumina Software, Inc.	Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en)	2021-12-23	2023-07-06	Illumina Software, Inc.	Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129898A2 (en)	2021-12-27	2023-07-06	10X Genomics, Inc.	Methods and compositions for rolling circle amplification
US20230207050A1 (en)	2021-12-28	2023-06-29	Illumina Software, Inc.	Machine learning model for recalibrating nucleotide base calls corresponding to target variants
CA3222937A1 (en)	2021-12-29	2023-07-06	Jonathan Mark Boutell	Methods of nucleic acid sequencing using surface-bound primers
JP2025504332A (ja)	2021-12-29	2025-02-12	イルミナインコーポレイテッド	ゲノム分析アプリケーションのためのバリアント分析モデルバージョンの自動切り替え
AU2023208743A1 (en)	2022-01-20	2024-01-04	Illumina, Inc.	Methods of detecting methylcytosine and hydroxymethylcytosine by sequencing
US20230279475A1 (en)	2022-01-21	2023-09-07	10X Genomics, Inc.	Multiple readout signals for analyzing a sample
WO2023164570A1 (en)	2022-02-23	2023-08-31	Insitro, Inc.	Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations
EP4483371A1 (en)	2022-02-25	2025-01-01	Illumina, Inc.	Machine-learning models for detecting and adjusting values for nucleotide methylation levels
EP4483372A1 (en)	2022-02-25	2025-01-01	Illumina, Inc.	Calibration sequences for nucelotide sequencing
WO2023172665A2 (en)	2022-03-10	2023-09-14	Singular Genomics Systems, Inc.	Nucleic acid delivery scaffolds
WO2023175029A1 (en)	2022-03-15	2023-09-21	Illumina, Inc.	Concurrent sequencing of hetero n-mer polynucleotides
EP4500536A1 (en)	2022-03-25	2025-02-05	Illumina, Inc.	Sequence-to-sequence base calling
EP4500157A1 (en)	2022-03-29	2025-02-05	Nautilus Subsidiary, Inc.	Integrated arrays for single-analyte processes
CN119032271A (zh)	2022-04-01	2024-11-26	10X基因组学有限公司	用于靶向掩蔽自发荧光的组合物和方法
CN119234045A (zh)	2022-04-06	2024-12-31	10X基因组学有限公司	用于多重细胞分析的方法
CN119053701A (zh)	2022-04-07	2024-11-29	因美纳有限公司	经改变的胞苷脱氨酶和使用方法
WO2023196528A1 (en)	2022-04-08	2023-10-12	Illumina, Inc.	Aptamer dynamic range compression and detection techniques
WO2023212490A1 (en)	2022-04-25	2023-11-02	Nautilus Subsidiary, Inc.	Systems and methods for assessing and improving the quality of multiplex molecular assays
US20230340571A1 (en)	2022-04-26	2023-10-26	Illumina, Inc.	Machine-learning models for selecting oligonucleotide probes for array technologies
WO2023209606A1 (en)	2022-04-29	2023-11-02	Illumina Cambridge Limited	Methods and systems for encapsulating lyophilised microspheres
WO2023215612A1 (en)	2022-05-06	2023-11-09	10X Genomics, Inc.	Analysis of antigen and antigen receptor interactions
WO2023220627A1 (en)	2022-05-10	2023-11-16	Illumina Software, Inc.	Adaptive neural network for nucelotide sequencing
CN119546761A (zh)	2022-05-18	2025-02-28	因美纳有限公司	大小受控的核酸片段的制备
EP4526471A1 (en)	2022-05-19	2025-03-26	Agendia N.V.	Dna repair signature and prediction of response following cancer therapy
EP4526470A1 (en)	2022-05-19	2025-03-26	Agendia N.V.	Prediction of response to immune therapy in breast cancer patients
WO2023235353A2 (en)	2022-06-03	2023-12-07	Illumina, Inc.	Circulating rna biomarkers for preeclampsia
US20240035071A1 (en)	2022-06-17	2024-02-01	10X Genomics, Inc.	Catalytic de-crosslinking of samples for in situ analysis
CN119422201A (zh)	2022-06-24	2025-02-11	因美纳有限公司	通过智能鉴定候选分割组并评分来改进分割-读段比对
WO2024006705A1 (en)	2022-06-27	2024-01-04	Illumina Software, Inc.	Improved human leukocyte antigen (hla) genotyping
KR20250028287A (ko)	2022-06-27	2025-02-28	일루미나, 인코포레이티드	구조 변이 그래프 게놈의 생성 및 구현
US20230420075A1 (en)	2022-06-27	2023-12-28	Illumina Software, Inc.	Accelerators for a genotype imputation model
WO2024015962A1 (en)	2022-07-15	2024-01-18	Pacific Biosciences Of California, Inc.	Blocked asymmetric hairpin adaptors
US20240038327A1 (en)	2022-07-26	2024-02-01	Illumina Software, Inc.	Rapid single-cell multiomics processing using an executable file
WO2024036304A1 (en)	2022-08-12	2024-02-15	10X Genomics, Inc.	Puma1 polymerases and uses thereof
EP4511510A1 (en)	2022-08-16	2025-02-26	10X Genomics, Inc.	Ap50 polymerases and uses thereof
WO2024039516A1 (en)	2022-08-19	2024-02-22	Illumina, Inc.	Third dna base pair site-specific dna detection
WO2024059655A1 (en)	2022-09-15	2024-03-21	Nautilus Subsidiary, Inc.	Characterizing accessibility of macromolecule structures
WO2024059852A1 (en)	2022-09-16	2024-03-21	Illumina, Inc.	Cluster segmentation and conditional base calling
CN118974830A (zh)	2022-09-29	2024-11-15	因美纳有限公司	用于推算靶变体的靶变体参考组
US20240141427A1 (en)	2022-09-30	2024-05-02	Illumina, Inc.	Polymerases, compositions, and methods of use
WO2024069581A1 (en)	2022-09-30	2024-04-04	Illumina Singapore Pte. Ltd.	Helicase-cytidine deaminase complexes and methods of use
US20240120027A1 (en)	2022-09-30	2024-04-11	Illumina, Inc.	Machine-learning model for refining structural variant calls
WO2024073047A1 (en)	2022-09-30	2024-04-04	Illumina, Inc.	Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024073043A1 (en)	2022-09-30	2024-04-04	Illumina, Inc.	Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024077096A1 (en)	2022-10-05	2024-04-11	Illumina, Inc.	Integrating variant calls from multiple sequencing pipelines utilizing a machine learning architecture
WO2024077152A1 (en)	2022-10-06	2024-04-11	Illumina, Inc.	Probes for depleting abundant small noncoding rna
EP4482987A2 (en)	2022-10-06	2025-01-01	Illumina, Inc.	Probes for improving coronavirus sample surveillance
WO2024077202A2 (en)	2022-10-06	2024-04-11	Illumina, Inc.	Probes for improving environmental sample surveillance
WO2024081649A1 (en)	2022-10-11	2024-04-18	Illumina, Inc.	Detecting and correcting methylation values from methylation sequencing assays
US20240191297A1 (en)	2022-10-14	2024-06-13	10X Genomics, Inc.	Methods, compositions, and systems for assessing biological sample quality
WO2024083883A1 (en)	2022-10-19	2024-04-25	Dna Script	Methods and products for removal of uracil containing polynucleotides
US20240167081A1 (en)	2022-11-08	2024-05-23	10X Genomics,Inc.	Immobilization methods and compositions for in situ detection
US20240158852A1 (en)	2022-11-16	2024-05-16	10X Genomics, Inc.	Methods and compositions for assessing performance of in situ assays
WO2024118903A1 (en)	2022-11-30	2024-06-06	Illumina, Inc.	Chemoenzymatic correction of false positive uracil transformations
WO2024118791A1 (en)	2022-11-30	2024-06-06	Illumina, Inc.	Accurately predicting variants from methylation sequencing data
WO2024121022A1 (en)	2022-12-05	2024-06-13	Dna Script	Variants of poly(a) polymerase and uses thereof
WO2024129672A1 (en)	2022-12-12	2024-06-20	The Broad Institute, Inc.	Trafficked rnas for assessment of cell-cell connectivity and neuroanatomy
US20240209419A1 (en)	2022-12-14	2024-06-27	Illumina, Inc.	Systems and Methods for Capture and Enrichment of Clustered Beads on Flow Cell Substrates
WO2024130031A1 (en)	2022-12-16	2024-06-20	Illumina, Inc.	Boranes on solid supports
US20240218437A1 (en)	2022-12-16	2024-07-04	10X Genomics, Inc.	Methods and compositions for assessing performance
US20240212791A1 (en)	2022-12-21	2024-06-27	Illumina, Inc.	Context-dependent base calling
WO2024137860A1 (en)	2022-12-21	2024-06-27	10X Genomics, Inc.	Methods for tethering ribonucleic acids in biological samples
CN119095983A (zh)	2022-12-22	2024-12-06	伊路米纳有限公司	用于边合成边测序的过渡金属催化剂组合物和方法
CN119095982A (zh)	2022-12-22	2024-12-06	伊路米纳有限公司	用于边合成边测序的钯催化剂组合物和方法
WO2024145154A1 (en)	2022-12-27	2024-07-04	Illumina, Inc.	Methods of sequencing using 3´ allyl blocked nucleotides
WO2024141628A1 (en)	2022-12-31	2024-07-04	Dna Script	Variable viscosity inks for inkjet delivery of enzyme reagents
US20240263219A1 (en)	2023-01-06	2024-08-08	10X Genomics, Inc.	Methods and compositions for in situ analysis of variant sequences
AU2023421715A1 (en)	2023-01-06	2024-09-26	Illumina, Inc.	Reducing uracils by polymerase
US20240241110A1 (en)	2023-01-12	2024-07-18	Nautilus Subsidiary, Inc.	Characterization of glycans and glycoconjugates
WO2024153642A1 (en)	2023-01-16	2024-07-25	Dna Script	Scarless template-free enzymatic synthesis of polynucleotides
WO2024153643A1 (en)	2023-01-16	2024-07-25	Dna Script	Inkjet-assisted enzymatic nucleic acid synthesis
WO2024156896A2 (en)	2023-01-26	2024-08-02	Dna Script	Enzymatic synthesis of polynucleotide probes
CN119452420A (zh)	2023-02-06	2025-02-14	因美纳有限公司	确定和去除簇间光干扰
CN119630812A (zh)	2023-02-17	2025-03-14	因美纳有限公司	作为先兆子痫的生物标志物的细胞游离dna信号
AU2024235961A1 (en)	2023-03-10	2025-01-09	Illumina, Inc.	Aptamer detection techniques
WO2024206848A1 (en)	2023-03-30	2024-10-03	Illumina, Inc.	Tandem repeat genotyping
US20240327909A1 (en)	2023-03-30	2024-10-03	Illumina, Inc.	Compositions and methods for nucleic acid sequencing
AU2024266370A1 (en)	2023-05-03	2025-01-16	Illumina, Inc.	Machine learning model for recalibrating genotype calls from existing sequencing data files
US20240368678A1 (en)	2023-05-03	2024-11-07	10X Genomics, Inc.	Methods and compositions for spatial assay
WO2024249200A1 (en)	2023-05-26	2024-12-05	Illumina, Inc.	Methods for preserving methylation status during clustering
US20240404624A1 (en)	2023-05-31	2024-12-05	Illumina, Inc.	Structural variant alignment and variant calling by utilizing a structural-variant reference genome
WO2024249591A1 (en)	2023-05-31	2024-12-05	Illumina, Inc.	Methods for double-stranded sequencing by synthesis
WO2024249466A1 (en)	2023-05-31	2024-12-05	Illumina, Inc.	False positive reduction by translesion polymerase repair
WO2024249973A2 (en)	2023-06-02	2024-12-05	Illumina, Inc.	Linking human genes to clinical phenotypes using graph neural networks
WO2024254003A1 (en)	2023-06-05	2024-12-12	Illumina, Inc.	Identification and mapping of methylation sites
WO2024256604A1 (en)	2023-06-15	2024-12-19	Dna Script	Salt addition during enzymatic polynucleotide synthesis
WO2025006432A1 (en)	2023-06-26	2025-01-02	Pacific Biosciences Of California, Inc.	Compositions and methods for nucleic acid extension
WO2025006565A1 (en)	2023-06-27	2025-01-02	Illumina, Inc.	Variant calling with methylation-level estimation
WO2025006874A1 (en)	2023-06-30	2025-01-02	Illumina, Inc.	Machine-learning model for recalibrating genotype calls corresponding to germline variants and somatic mosaic variants
WO2025006464A1 (en)	2023-06-30	2025-01-02	Illumina, Inc.	Systems and methods of sequencing polynucleotides with alternative scatterplots
WO2025006460A1 (en)	2023-06-30	2025-01-02	Illumina, Inc.	Systems and methods of sequencing polynucleotides with modified bases
WO2025006466A1 (en)	2023-06-30	2025-01-02	Illumina, Inc.	Systems and methods of sequencing polynucleotides with four labeled nucleotides
WO2025003434A1 (en)	2023-06-30	2025-01-02	Dna Script	Nucleic acid synthesis on reusable support
WO2025006487A1 (en)	2023-06-30	2025-01-02	Illumina, Inc.	Using flowcell spatial coordinates to link reads for improved genome analysis
WO2025010160A1 (en)	2023-07-06	2025-01-09	Pacific Biosciences Of California, Inc.	Methods and compositions for stabilizing concatemers
WO2025024672A1 (en)	2023-07-26	2025-01-30	Element Biosciences, Inc.	Dna sequencing systems and use thereof
WO2025029831A1 (en)	2023-07-31	2025-02-06	10X Genomics, Inc.	Methods and systems for targeted rna cleavage and target rna-primed rolling circle amplification
GB202312147D0 (en)	2023-08-08	2023-09-20	Syndex Bio Ltd	Methylation method
WO2025049720A2 (en)	2023-08-31	2025-03-06	Illumina, Inc.	Aptamer dynamic range compression and detection techniques
WO2025049331A2 (en)	2023-08-31	2025-03-06	Illumina, Inc.	Aptamer detection techniques
WO2025054389A1 (en)	2023-09-07	2025-03-13	Illumina, Inc.	Identification of methylated cytosine using landmarks
WO2025050463A1 (en)	2023-09-08	2025-03-13	The Regents Of The University Of Michigan	MICRORNA-DERIVED RNAs AND POLYPEPTIDES AND USES THEREOF

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4711955A (en) *	1981-04-17	1987-12-08	Yale University	Modified nucleotides and methods of preparing and using same
US5175269A (en)	1984-01-30	1992-12-29	Enzo Diagnostics, Inc.	Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US5118605A (en) *	1984-10-16	1992-06-02	Chiron Corporation	Polynucleotide determination with selectable cleavage sites
US4824775A (en) *	1985-01-03	1989-04-25	Molecular Diagnostics, Inc.	Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
US4772691A (en)	1985-06-05	1988-09-20	The Medical College Of Wisconsin, Inc.	Chemically cleavable nucleotides
US4863849A (en) *	1985-07-18	1989-09-05	New York Medical College	Automatable process for sequencing nucleotide
US5151507A (en)	1986-07-02	1992-09-29	E. I. Du Pont De Nemours And Company	Alkynylamino-nucleotides
SE8801070D0 (sv)	1988-03-23	1988-03-23	Pharmacia Ab	Method for immobilizing a dna sequence on a solid support
US5174962A (en) *	1988-06-20	1992-12-29	Genomyx, Inc.	Apparatus for determining DNA sequences by mass spectrometry
GB8910880D0 (en)	1989-05-11	1989-06-28	Amersham Int Plc	Sequencing method
US5547839A (en)	1989-06-07	1996-08-20	Affymax Technologies N.V.	Sequencing of surface immobilized polymers utilizing microflourescence detection
JPH07111484B2 (ja) *	1989-06-26	1995-11-29	松下電器産業株式会社	プラスチック製光学部品の反射防止膜とその形成方法
US5302509A (en)	1989-08-14	1994-04-12	Beckman Instruments, Inc.	Method for sequencing polynucleotides
WO1991006678A1 (en) *	1989-10-26	1991-05-16	Sri International	Dna sequencing
WO1993005183A1 (en)	1991-09-09	1993-03-18	Baylor College Of Medicine	Method and device for rapid dna or rna sequencing determination by a base addition sequencing scheme
DE4141178A1 (de)	1991-12-13	1993-06-17	Europ Lab Molekularbiolog	Verfahren zur sequenzierung von nukleinsaeuren
GB9208733D0 (en)	1992-04-22	1992-06-10	Medical Res Council	Dna sequencing method
GB9210176D0 (en) *	1992-05-12	1992-06-24	Cemu Bioteknik Ab	Chemical method
US5436143A (en)	1992-12-23	1995-07-25	Hyman; Edward D.	Method for enzymatic synthesis of oligonucleotides
US5516664A (en)	1992-12-23	1996-05-14	Hyman; Edward D.	Enzymatic synthesis of repeat regions of oligonucleotides
US6074823A (en) *	1993-03-19	2000-06-13	Sequenom, Inc.	DNA sequencing by mass spectrometry via exonuclease degradation
FR2703052B1 (fr)	1993-03-26	1995-06-02	Pasteur Institut	Nouvelle méthode de séquençage d'acides nucléiques.
GB9315847D0 (en) *	1993-07-30	1993-09-15	Isis Innovation	Tag reagent and assay method
US5547859A (en) *	1993-08-02	1996-08-20	Goodman; Myron F.	Chain-terminating nucleotides for DNA sequencing methods
JPH09505397A (ja) *	1993-11-17	1997-05-27	アマーシャム・インターナショナル・ピーエルシー	プライマー伸長質量分光分析による核酸配列決定法
US5763594A (en)	1994-09-02	1998-06-09	Andrew C. Hiatt	3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US5872244A (en)	1994-09-02	1999-02-16	Andrew C. Hiatt	3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US5808045A (en) *	1994-09-02	1998-09-15	Andrew C. Hiatt	Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6232465B1 (en) *	1994-09-02	2001-05-15	Andrew C. Hiatt	Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6214987B1 (en)	1994-09-02	2001-04-10	Andrew C. Hiatt	Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
WO1996011937A1 (en) *	1994-10-14	1996-04-25	Stratagene	Porphyrin labeling of polynucleotides
SE9500342D0 (sv)	1995-01-31	1995-01-31	Marek Kwiatkowski	Novel chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation
AU5171696A (en)	1995-02-27	1996-09-18	Ely Michael Rabani	Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
EP0745686A1 (en) *	1995-06-01	1996-12-04	Roche Diagnostics GmbH	The use of DNA polymerase 3'-intrinsic editing activity
US6312893B1 (en) *	1996-01-23	2001-11-06	Qiagen Genomics, Inc.	Methods and compositions for determining the sequence of nucleic acid molecules
US6613508B1 (en) *	1996-01-23	2003-09-02	Qiagen Genomics, Inc.	Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
EP0992511B1 (en)	1996-01-23	2009-03-11	Operon Biotechnologies, Inc.	Methods and compositions for determining the sequence of nucleic acid molecules
US6005125A (en)	1996-05-06	1999-12-21	Rutgers The State University Of New Jersey	Universal allyl linker for solid-phase nucleic acid synthesis
US5821356A (en) *	1996-08-12	1998-10-13	The Perkin Elmer Corporation	Propargylethoxyamino nucleotides
US5885775A (en) *	1996-10-04	1999-03-23	Perseptive Biosystems, Inc.	Methods for determining sequences information in polynucleotides using mass spectrometry
JP2001508657A (ja)	1997-01-08	2001-07-03	プロリゴ・エルエルシー	オリゴヌクレオチドのバイオコンジュゲーション
US6046005A (en) *	1997-01-15	2000-04-04	Incyte Pharmaceuticals, Inc.	Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
US6136543A (en) *	1997-01-31	2000-10-24	Hitachi, Ltd.	Method for determining nucleic acids base sequence and apparatus therefor
PT1017848E (pt)	1997-07-28	2003-02-28	Medical Biosystems Ltd	Analise de sequencias de acido nucleico
US6008379A (en) *	1997-10-01	1999-12-28	The Perkin-Elmer Corporation	Aromatic-substituted xanthene dyes
US6485944B1 (en)	1997-10-10	2002-11-26	President And Fellows Of Harvard College	Replica amplification of nucleic acid arrays
GB9815163D0 (en)	1998-07-13	1998-09-09	Brax Genomics Ltd	Compounds
US6780591B2 (en) *	1998-05-01	2004-08-24	Arizona Board Of Regents	Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
JP3813818B2 (ja) *	1998-05-01	2006-08-23	アリゾナボードオブリージェンツ	オリゴヌクレオチドおよびｄｎａ分子のヌクレオチド配列の決定方法
US6096875A (en) *	1998-05-29	2000-08-01	The Perlein-Elmer Corporation	Nucleotide compounds including a rigid linker
US6218530B1 (en) *	1998-06-02	2001-04-17	Ambergen Inc.	Compounds and methods for detecting biomolecules
US6287821B1 (en) *	1998-06-11	2001-09-11	Orchid Biosciences, Inc.	Nucleotide analogues with 3'-pro-fluorescent fluorophores in nucleic acid sequence analysis
US6218118B1 (en) *	1998-07-09	2001-04-17	Agilent Technologies, Inc.	Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
GB0002310D0 (en)	2000-02-01	2000-03-22	Solexa Ltd	Polynucleotide sequencing
DE69928265T3 (de)	1998-07-30	2013-11-28	Illumina Cambridge Ltd.	Matrizen von biomolekülen und ihre verwendung in sequenzierung
US6787308B2 (en) *	1998-07-30	2004-09-07	Solexa Ltd.	Arrayed biomolecules and their use in sequencing
DE19844931C1 (de) *	1998-09-30	2000-06-15	Stefan Seeger	Verfahren zur DNS- oder RNS-Sequenzierung
US6451525B1 (en)	1998-12-03	2002-09-17	Pe Corporation (Ny)	Parallel sequencing method
US6380378B1 (en)	1998-12-24	2002-04-30	Toagosei Company, Ltd.	Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
ATE556149T1 (de) *	1999-02-23	2012-05-15	Caliper Life Sciences Inc	Manipulation von mikropartikeln in mikrofluidischen systemen
DK1159453T3 (da)	1999-03-10	2008-10-06	Asm Scient Inc	Fremgangsmåde til direkte nukleinsyresekventering
US7037654B2 (en)	1999-04-30	2006-05-02	Aclara Biosciences, Inc.	Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7056661B2 (en)	1999-05-19	2006-06-06	Cornell Research Foundation, Inc.	Method for sequencing nucleic acid molecules
US6818395B1 (en) *	1999-06-28	2004-11-16	California Institute Of Technology	Methods and apparatus for analyzing polynucleotide sequences
US6242193B1 (en) *	1999-07-30	2001-06-05	Hitachi, Ltd.	Apparatus for determining base sequence of nucleic acid
AU7086800A (en)	1999-08-30	2001-03-26	Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The	High speed parallel molecular nucleic acid sequencing
US6982146B1 (en) *	1999-08-30	2006-01-03	The United States Of America As Represented By The Department Of Health And Human Services	High speed parallel molecular nucleic acid sequencing
WO2001023610A2 (en)	1999-09-29	2001-04-05	Solexa Ltd.	Polynucleotide sequencing
US6309836B1 (en)	1999-10-05	2001-10-30	Marek Kwiatkowski	Compounds for protecting hydroxyls and methods for their use
JP2003516129A (ja)	1999-11-04	2003-05-13	カリフォルニア・インスティテュート・オブ・テクノロジー	ポリヌクレオチド配列を解析する方法および装置
US20030186256A1 (en) *	1999-12-23	2003-10-02	Achim Fischer	Method for carrying out the parallel sequencing of a nucleic acid mixture on a surface
GB0002389D0 (en)	2000-02-02	2000-03-22	Solexa Ltd	Molecular arrays
WO2001073121A1 (fr)	2000-03-30	2001-10-04	Toyota Jidosha Kabushiki Kaisha	Procede pour determiner une sequence de base d'une molecule individuelle d'acide nucleique
GB0013276D0 (en) *	2000-06-01	2000-07-26	Amersham Pharm Biotech Uk Ltd	Nucleotide analogues
GB0016473D0 (en)	2000-07-05	2000-08-23	Amersham Pharm Biotech Uk Ltd	Sequencing method
AU8911101A (en)	2000-09-11	2002-03-26	Univ Columbia	Combinatorial fluorescence energy transfer tags and uses thereof
DE10045592A1 (de)	2000-09-15	2002-03-28	Klaus Pfizenmaier	Ein Antikörper-TNF-TNF Inhibitor Fusionsprotein (TNF-Selektokin) als zielspezifisches Prozytokin zur Tumortherapie
ATE356222T1 (de)	2000-10-06	2007-03-15	Univ Columbia	Massives parallelverfahren zur dekodierung von dna und rna
US7297518B2 (en)	2001-03-12	2007-11-20	California Institute Of Technology	Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
US20030027140A1 (en)	2001-03-30	2003-02-06	Jingyue Ju	High-fidelity DNA sequencing using solid phase capturable dideoxynucleotides and mass spectrometry
DE10120797B4 (de)	2001-04-27	2005-12-22	Genovoxx Gmbh	Verfahren zur Analyse von Nukleinsäureketten
DE10120798B4 (de)	2001-04-27	2005-12-29	Genovoxx Gmbh	Verfahren zur Bestimmung der Genexpression
US6613523B2 (en)	2001-06-29	2003-09-02	Agilent Technologies, Inc.	Method of DNA sequencing using cleavable tags
AU2002354577B2 (en) *	2001-07-13	2007-02-08	Ambergen, Inc.	Nucleotide compositions comprising photocleavable markers and methods of preparation thereof
AU2002337030A1 (en)	2001-08-29	2003-03-18	Genovoxx Gmbh	Method for analyzing nucleic acid sequences and gene expression
GB0128526D0 (en)	2001-11-29	2002-01-23	Amersham Pharm Biotech Uk Ltd	Nucleotide analogues
US7057026B2 (en)	2001-12-04	2006-06-06	Solexa Limited	Labelled nucleotides
CA2481495C (en)	2002-04-04	2011-08-30	Biotage Ab	Primer extension based method employing nucleotides labelled via cleavable linkers
AU2003224836A1 (en)	2002-04-12	2003-10-27	Stratagene	Dual-labeled nucleotides
US7074597B2 (en) *	2002-07-12	2006-07-11	The Trustees Of Columbia University In The City Of New York	Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
US7414116B2 (en)	2002-08-23	2008-08-19	Illumina Cambridge Limited	Labelled nucleotides
DK3363809T3 (da)	2002-08-23	2020-05-04	Illumina Cambridge Ltd	Modificerede nukleotider til polynukleotidsekvensering
DK1560838T3 (da)	2002-08-23	2009-09-07	Illumina Cambridge Ltd	M rkede nuklotider
GB0321306D0 (en)	2003-09-11	2003-10-15	Solexa Ltd	Modified polymerases for improved incorporation of nucleotide analogues
US7067031B2 (en) *	2003-12-03	2006-06-27	Dew Engineering And Development Limited	Process for making a ceramic armor plate
CA2557818A1 (en)	2004-03-03	2005-09-15	The Trustees Of Columbia University In The City Of New York	Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry
HRP20211523T1 (hr)	2011-09-23	2021-12-24	Illumina, Inc.	Pripravci za sekvenciranje nukleinske kiseline

2002
- 2002-08-23 US US10/227,131 patent/US7057026B2/en not_active Expired - Lifetime
- 2002-12-04 EP EP17177650.3A patent/EP3266791B1/en not_active Expired - Lifetime
- 2002-12-04 SI SI200231100T patent/SI3266791T1/sl unknown
- 2002-12-04 EP EP21153272.6A patent/EP3858845A1/en not_active Withdrawn
- 2002-12-04 DK DK17177650.3T patent/DK3266791T3/da active
- 2002-12-04 EP EP02781434.2A patent/EP1451351B1/en not_active Revoked
- 2002-12-04 US US10/497,594 patent/US7427673B2/en not_active Expired - Lifetime
- 2002-12-04 CN CNA028278321A patent/CN1617937A/zh active Pending
- 2002-12-04 WO PCT/GB2002/005474 patent/WO2003048387A2/en active Application Filing
- 2002-12-04 JP JP2003549564A patent/JP2005511058A/ja not_active Withdrawn
- 2002-12-04 BR BR0214683-5A patent/BR0214683A/pt not_active Application Discontinuation
- 2002-12-04 ES ES17177650T patent/ES2858359T3/es not_active Expired - Lifetime
- 2002-12-04 PT PT171776503T patent/PT3266791T/pt unknown
- 2002-12-04 EP EP10180384.9A patent/EP2338893B9/en not_active Revoked
- 2002-12-04 PT PT2781434T patent/PT1451351T/pt unknown
- 2002-12-04 AU AU2002349155A patent/AU2002349155A1/en not_active Abandoned
- 2002-12-04 IL IL16217002A patent/IL162170A0/xx unknown
- 2002-12-04 CA CA002469066A patent/CA2469066A1/en not_active Abandoned
- 2002-12-04 DK DK02781434.2T patent/DK1451351T3/en active
- 2002-12-04 ES ES02781434.2T patent/ES2620131T3/es not_active Expired - Lifetime
- 2002-12-04 KR KR1020047008502A patent/KR20050044668A/ko not_active Application Discontinuation
2004
- 2004-06-01 IS IS7291A patent/IS7291A/is unknown
2005
- 2005-12-13 US US11/301,578 patent/US7566537B2/en not_active Expired - Lifetime
2009
- 2009-07-23 US US12/460,741 patent/US7785796B2/en not_active Expired - Lifetime
2017
- 2017-03-21 CY CY20171100360T patent/CY1118765T1/el unknown
2018
- 2018-06-28 HK HK18108333.9A patent/HK1248710A1/zh not_active IP Right Cessation
2021
- 2021-02-23 CY CY20211100153T patent/CY1123882T1/el unknown

Also Published As

Publication number	Publication date
BR0214683A (pt)	2004-11-23
WO2003048387A3 (en)	2003-10-16
PT1451351T (pt)	2017-03-29
ES2858359T3 (es)	2021-09-30
US7427673B2 (en)	2008-09-23
IL162170A0 (en)	2005-11-20
ES2620131T3 (es)	2017-06-27
US7785796B2 (en)	2010-08-31
US20060188901A1 (en)	2006-08-24
JP2005511058A (ja)	2005-04-28
EP2338893B1 (en)	2017-06-28
EP3266791A1 (en)	2018-01-10
US20030104437A1 (en)	2003-06-05
SI3266791T1 (sl)	2021-04-30
KR20050044668A (ko)	2005-05-12
CY1118765T1 (el)	2017-07-12
CY1123882T1 (el)	2022-05-27
DK3266791T3 (da)	2021-03-01
EP2338893B9 (en)	2019-12-25
HK1248710A1 (zh)	2018-10-19
US7057026B2 (en)	2006-06-06
EP1451351B1 (en)	2017-02-01
CN1617937A (zh)	2005-05-18
US20100028885A1 (en)	2010-02-04
AU2002349155A1 (en)	2003-06-17
US7566537B2 (en)	2009-07-28
WO2003048387A2 (en)	2003-06-12
EP2338893A1 (en)	2011-06-29
EP3266791B1 (en)	2021-01-27
DK1451351T3 (en)	2017-03-27
US20060160075A1 (en)	2006-07-20
CA2469066A1 (en)	2003-06-12
EP1451351A2 (en)	2004-09-01
IS7291A (is)	2004-06-01
EP3858845A1 (en)	2021-08-04

Publication	Publication Date	Title
HK1248710A1 (zh)	2018-10-19	標記過的核苷酸
GB0129012D0 (en)	2002-01-23	Labelled nucleotides
GB2381289B (en)	2005-09-14	Clip
DE60229476D1 (en)	2008-12-04	Biosensor
DE60205702D1 (en)	2005-09-29	Biosensor
EP1398626A4 (en)	2004-09-22	BIOSENSOR
EP1421371A4 (en)	2008-08-27	BIOSENSOR
EP1452856A4 (en)	2006-06-07	BIOSENSOR
EP1353546A4 (en)	2009-07-22	METHOD AND DEVICE FOR MONITORING PULSATION FOR TREATMENT DEVICE
AU148309S (en)	2002-07-01	Clip
TW568197U (en)	2003-12-21	Clip
TW545411U (en)	2003-08-01	Clip
GB0108110D0 (en)	2001-05-23	Keeps
HUP0202901A2 (hu)	2004-04-28	Módosított metatézis-katalizátorok
CA93850S (en)	2001-11-16	Biosensor
GB2379712B (en)	2003-11-12	Retaining clip
GB0313637D0 (en)	2003-07-16	Labelled nucleotides
GB0103234D0 (en)	2001-03-28	Labelling
AU148248S (en)	2002-06-20	Clip
GB0108947D0 (en)	2001-05-30	Biosensor
GB0101279D0 (en)	2001-02-28	Biosensor
GB0108536D0 (en)	2001-05-23	Biosensor
GB0125687D0 (en)	2001-12-19	Ride-a-light - glow bike
GB0117008D0 (en)	2001-09-05	Easy carry
GB0106062D0 (en)	2001-05-02	Easy can