PT2776038T - Inibidores de acc e utilizações dos mesmos - Google Patents
Inibidores de acc e utilizações dos mesmosInfo
- Publication number
- PT2776038T PT2776038T PT128483617T PT12848361T PT2776038T PT 2776038 T PT2776038 T PT 2776038T PT 128483617 T PT128483617 T PT 128483617T PT 12848361 T PT12848361 T PT 12848361T PT 2776038 T PT2776038 T PT 2776038T
- Authority
- PT
- Portugal
- Prior art keywords
- acc inhibitors
- acc
- inhibitors
- Prior art date
Links
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559023P | 2011-11-11 | 2011-11-11 | |
| US201261615092P | 2012-03-23 | 2012-03-23 | |
| US201261651878P | 2012-05-25 | 2012-05-25 | |
| US201261675513P | 2012-07-25 | 2012-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2776038T true PT2776038T (pt) | 2018-04-18 |
Family
ID=48281206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT128483617T PT2776038T (pt) | 2011-11-11 | 2012-11-09 | Inibidores de acc e utilizações dos mesmos |
| PT172094559T PT3329919T (pt) | 2011-11-11 | 2012-11-09 | Inibidores de acc e suas utilizações |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT172094559T PT3329919T (pt) | 2011-11-11 | 2012-11-09 | Inibidores de acc e suas utilizações |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US8969557B2 (pt) |
| EP (3) | EP2776038B1 (pt) |
| JP (4) | JP6114297B2 (pt) |
| KR (3) | KR102060290B1 (pt) |
| CN (3) | CN106905346B (pt) |
| AU (3) | AU2012335088B2 (pt) |
| BR (2) | BR112014011351B1 (pt) |
| CA (1) | CA2855372C (pt) |
| CL (1) | CL2014001241A1 (pt) |
| CY (2) | CY1120224T1 (pt) |
| DK (2) | DK2776038T3 (pt) |
| EA (2) | EA033598B1 (pt) |
| ES (3) | ES2912574T3 (pt) |
| HR (2) | HRP20180534T1 (pt) |
| HU (2) | HUE047049T2 (pt) |
| LT (2) | LT2776038T (pt) |
| MX (3) | MX370976B (pt) |
| PL (3) | PL2776038T3 (pt) |
| PT (2) | PT2776038T (pt) |
| RS (1) | RS57157B1 (pt) |
| SI (2) | SI3329919T1 (pt) |
| SM (1) | SMT201800191T1 (pt) |
| TW (4) | TWI701253B (pt) |
| UA (2) | UA114901C2 (pt) |
| WO (1) | WO2013071169A1 (pt) |
| ZA (3) | ZA201403633B (pt) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| LT2776038T (lt) * | 2011-11-11 | 2018-04-25 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| CA2871547C (en) | 2012-05-25 | 2021-05-25 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
| CN105142673B8 (zh) | 2012-12-18 | 2018-02-16 | 阿尔米雷尔有限公司 | 具有β2肾上腺素能激动剂及M3毒蕈碱拮抗剂活性的新型环己基和奎宁环基氨基甲酸酯衍生物 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| CA2911818A1 (en) * | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
| MX2015015422A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
| US9988399B2 (en) * | 2013-05-10 | 2018-06-05 | Gilead Apollo, Llc | Bicyclic compounds as ACC inhibitors and uses thereof |
| EP2994141A4 (en) * | 2013-05-10 | 2016-11-23 | Nimbus Apollo Inc | ACC-HEMMER AND USES THEREOF |
| WO2015003879A1 (en) * | 2013-07-08 | 2015-01-15 | Syngenta Participations Ag | Microbiocidal heterobicylic derivatives |
| WO2015003881A1 (en) * | 2013-07-08 | 2015-01-15 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015007453A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015007451A1 (en) | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015010832A1 (en) * | 2013-07-22 | 2015-01-29 | Syngenta Participations Ag | Microbiocidal heterocyclic derivatives |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| WO2015036892A1 (en) | 2013-09-12 | 2015-03-19 | Pfizer Inc. | Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris |
| JP2016532721A (ja) | 2013-10-07 | 2016-10-20 | バイエル ファーマ アクチエンゲゼルシャフト | 環状チエノウラシルカルボキサミドおよびその使用 |
| WO2015056782A1 (ja) | 2013-10-17 | 2015-04-23 | 塩野義製薬株式会社 | 新規アルキレン誘導体 |
| RU2674977C2 (ru) * | 2013-10-30 | 2018-12-14 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Производные пиразолопиримидона или пирролотриазона, способ их получения и их фармацевтические применения |
| TN2016000253A1 (en) | 2013-12-19 | 2017-10-06 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis. |
| WO2016023832A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| CN105779463B (zh) * | 2014-12-25 | 2019-08-09 | 深圳华大生命科学研究院 | Vps13b基因突变体及其应用 |
| HK1243369A1 (zh) * | 2015-01-09 | 2018-07-13 | 吉利德阿波罗公司 | 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗 |
| UY36586A (es) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | Heterociclilmetiltienouracilos y uso de los mismos |
| WO2016196895A1 (en) * | 2015-06-05 | 2016-12-08 | Joslin Diabetes Center, Inc. | Methods amd compositions for promoting thermogenic potential |
| CN105009933B (zh) * | 2015-06-10 | 2018-08-14 | 邓娟 | 一种以通风曲方式栽培草菇的工艺 |
| SI3191470T1 (sl) | 2015-07-06 | 2019-04-30 | Gilead Sciences, Inc. | Modulatorji COT in postopki njihove uporabe |
| AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| MX2018006287A (es) * | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc de triazol y usos de los mismos. |
| WO2017091602A1 (en) | 2015-11-25 | 2017-06-01 | Gilead Apollo, Llc | Ester acc inhibitors and uses thereof |
| EA201890913A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | Пиразоловые соединения в качестве ингибиторов акк и их применение |
| CN108347939B (zh) * | 2015-11-25 | 2021-09-28 | 吉利德阿波罗公司 | 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物 |
| LT3386591T (lt) | 2015-12-09 | 2020-10-12 | Cadent Therapeutics, Inc. | Heteroaromatiniai nmda receptoriaus moduliatoriai ir jų panaudojimas |
| ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
| WO2017147161A1 (en) * | 2016-02-23 | 2017-08-31 | Raju Mohan | Treatment of dermatological disorders or conditions |
| BR112018067408A2 (pt) | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
| CN107286174B (zh) * | 2016-04-11 | 2020-08-18 | 上海勋和医药科技有限公司 | 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用 |
| CN107629071B (zh) * | 2016-07-19 | 2019-12-27 | 上海勋和医药科技有限公司 | 取代2，4-（1h,3h）嘧啶二酮作为parp抑制剂及其应用 |
| WO2018041771A1 (de) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung |
| EP3515919A1 (de) | 2016-09-23 | 2019-07-31 | Bayer Aktiengesellschaft | N3-cyclisch substituierte thienouracile und ihre verwendung |
| US11274107B2 (en) | 2016-12-22 | 2022-03-15 | Cadent Therapeutics, Inc. | NMDA receptor modulators and uses thereof |
| KR102577824B1 (ko) * | 2017-01-22 | 2023-09-13 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 티에노피리미딘 유도체 및 의약에서 이의 용도 |
| KR102485620B1 (ko) * | 2017-03-03 | 2023-01-09 | 길리애드 사이언시즈, 인코포레이티드 | Acc 억제제 및 그의 고체 형태를 제조하는 방법 |
| JP2020509038A (ja) * | 2017-03-03 | 2020-03-26 | ギリアド アポロ， エルエルシー | 殺真菌剤化合物を調製するための方法 |
| US11142531B2 (en) | 2017-03-24 | 2021-10-12 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof |
| WO2018171698A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| CA3056925A1 (en) | 2017-03-28 | 2018-10-04 | Gilead Sciences, Inc. | Methods of treating liver disease |
| EP4122464B1 (en) | 2017-03-28 | 2024-05-15 | Gilead Sciences, Inc. | Therapeutic combinations for treating liver diseases |
| CA3055076C (en) | 2017-03-31 | 2022-02-22 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| CA3059883A1 (en) | 2017-04-12 | 2018-10-18 | Gilead Sciences, Inc. | Methods of treating liver disease |
| CN107151251A (zh) * | 2017-05-10 | 2017-09-12 | 江苏开元药业有限公司 | 一种acc抑制剂药物关键中间体的制备方法 |
| US10495648B2 (en) | 2017-06-13 | 2019-12-03 | Gilead Sciences, Inc. | Methods of treating liver fibrosis |
| CN110709402B (zh) * | 2017-06-15 | 2022-05-10 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
| WO2019015583A1 (en) | 2017-07-17 | 2019-01-24 | Nanjing Ruijie Pharmatech Co., Ltd. | NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS |
| TW201910338A (zh) | 2017-07-26 | 2019-03-16 | 大陸商南京聖和藥業股份有限公司 | 作為acc抑制劑的化合物及其應用 |
| TW201910334A (zh) * | 2017-07-28 | 2019-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種嘧啶酮并雜芳基類衍生物的製備方法及其中間體 |
| WO2019031384A1 (ja) * | 2017-08-07 | 2019-02-14 | 日本曹達株式会社 | １，３，５，６－テトラ置換チエノ［２，３－ｄ］ピリミジン－２，４（１Ｈ，３Ｈ）ジオン化合物および農園芸用殺菌剤 |
| KR20190036705A (ko) | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
| EP3691648A1 (en) | 2017-10-06 | 2020-08-12 | Gilead Sciences, Inc. | Combination therapy comprising an acc inhibitor |
| WO2019072478A1 (en) | 2017-10-10 | 2019-04-18 | Galderma Research & Development | SPECIFIC ACETYL-COA CARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT AND / OR PREVENTION OF ACNE |
| EP3710599B1 (en) | 2017-11-13 | 2024-07-17 | Gilead Sciences, Inc. | Method for staging liver fibrosis in nash patients |
| CN108129251A (zh) * | 2017-12-22 | 2018-06-08 | 上海应用技术大学 | 一种2-乙基苯乙烯的合成工艺 |
| WO2019233443A1 (zh) | 2018-06-05 | 2019-12-12 | 南京明德新药研发有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 |
| JP7319369B2 (ja) | 2018-08-03 | 2023-08-01 | ノバルティス アーゲー | ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用 |
| CN110950884B (zh) * | 2018-09-27 | 2024-03-26 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
| AU2019385438A1 (en) * | 2018-11-20 | 2021-05-27 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Spiro compound and medical uses thereof |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| PT3897589T (pt) | 2018-12-19 | 2026-01-21 | Corcept Therapeutics Incorporated | Formulações farmacêuticas contendo relacorilant, um composto de azadecalina fundido com heteroaril-cetona |
| EP3669652A1 (en) | 2018-12-21 | 2020-06-24 | Bayer AG | Active compound combination |
| EP3911647B1 (en) | 2019-01-15 | 2023-12-13 | Gilead Sciences, Inc. | Isoxazole compound as fxr agonist and pharmaceutical compositions comprising same |
| CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
| CN113490496A (zh) | 2019-02-22 | 2021-10-08 | 科赛普特治疗学股份有限公司 | 一种杂芳基-酮稠合氮杂萘烷糖皮质激素受体调节剂瑞拉可兰的治疗用途 |
| JP7697885B2 (ja) | 2019-03-11 | 2025-06-24 | ギリアード サイエンシーズ， インコーポレイテッド | 化合物の製剤およびそれらの使用 |
| CN111747916A (zh) * | 2019-03-27 | 2020-10-09 | 尚科生物医药（上海）有限公司 | (r)-2-(2-甲氧基苯基)-2-(四氢吡喃-4-氧基)乙-1-醇的制备方法 |
| CN109810085B (zh) * | 2019-04-19 | 2019-07-19 | 上海皓元生物医药科技有限公司 | Acc抑制剂及其中间体的制备方法 |
| CN111850061B (zh) * | 2019-04-30 | 2022-12-09 | 浙江工业大学 | 一种井冈羟胺a酯化物的制备方法 |
| CN110343650B (zh) * | 2019-05-28 | 2020-12-29 | 浙江工业大学 | 一种产两性霉素b的重组结节链霉菌及其应用 |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| WO2020255946A1 (ja) * | 2019-06-17 | 2020-12-24 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物及び農園芸用殺菌剤 |
| WO2021000242A1 (zh) | 2019-07-02 | 2021-01-07 | 广东东阳光药业有限公司 | 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用 |
| AR119594A1 (es) * | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| JP2022548617A (ja) | 2019-09-19 | 2022-11-21 | ノバルティス アーゲー | Ｆｘｒアゴニストを含む処置 |
| CN112574253B (zh) * | 2019-09-29 | 2021-08-27 | 上海喀露蓝科技有限公司 | 磷酸或磷酸酯类衍生物、其制备方法及其在医药上的用途 |
| CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
| PH12022551004A1 (en) | 2019-10-28 | 2023-03-13 | Nippon Soda Co | 2,6-dioxo-3,6-dihydropyrimidine compound, agricultural and horticultural bactericide, nematicide, and medical and veterinary antifungal agent |
| CN112778325A (zh) * | 2019-11-07 | 2021-05-11 | 南京瑞捷医药科技有限公司 | 一种acc抑制剂及其用途 |
| KR102775995B1 (ko) | 2019-11-15 | 2025-03-11 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도 |
| WO2021110138A1 (zh) | 2019-12-05 | 2021-06-10 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
| WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
| WO2021110135A1 (zh) | 2019-12-05 | 2021-06-10 | 漳州片仔癀药业股份有限公司 | 作为acc1和acc2抑制剂的晶型及其制备方法和应用 |
| KR20220113767A (ko) | 2019-12-11 | 2022-08-16 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 미리코릴란트로 항정신병약-유도 체중 증가를 치료하는 방법 |
| JP2023520650A (ja) | 2020-03-30 | 2023-05-18 | ギリアード サイエンシーズ， インコーポレイテッド | （Ｓ）－６－（（（１－（ビシクロ［１．１．１］ペンタン－１－イル）－１Ｈ－１，２，３－トリアゾール－４－イル）２－メチル－１－オキソ－１，２－ジヒドロイソキノリン－５－イル）メチル）））アミノ）８－クロロ－（ネオペンチルアミノ）キノリン－３－カルボニトリルＣｏｔ阻害剤化合物の固体形態 |
| PL4126862T3 (pl) | 2020-04-02 | 2025-09-08 | Gilead Sciences, Inc. | Sposób wytwarzania związku będącego inhibitorem cot |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN111513022B (zh) * | 2020-05-08 | 2021-11-12 | 武汉市农业科学院 | 一种低皮脂率的小体型肉鸭的选育方法 |
| CA3182134A1 (en) | 2020-05-21 | 2021-11-25 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating fatty liver disease |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| CA3185689A1 (en) | 2020-06-03 | 2021-12-09 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
| CN113967213A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 一种包含苯基取代类acc抑制剂的组合物及其用途 |
| CN111888349B (zh) * | 2020-07-29 | 2021-10-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 印楝素在制备促进缺血超长随意皮瓣存活药物的作用 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| WO2022166761A1 (zh) * | 2021-02-07 | 2022-08-11 | 正大天晴药业集团股份有限公司 | 噻吩并嘧啶衍生物 |
| US12091404B2 (en) | 2021-03-11 | 2024-09-17 | Gilead Sciences, Inc. | GLP-1R modulating compounds |
| CN117120429A (zh) | 2021-03-29 | 2023-11-24 | 吉利德科学公司 | Khk抑制剂 |
| US20240260575A1 (en) | 2021-04-28 | 2024-08-08 | Nippon Soda Co., Ltd. | Agricultural and horticultural fungicidal composition |
| AU2022273631B2 (en) | 2021-05-11 | 2025-04-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| WO2022241023A1 (en) | 2021-05-13 | 2022-11-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| TW202345826A (zh) | 2021-06-04 | 2023-12-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
| TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑 |
| JPWO2023090411A1 (pt) | 2021-11-19 | 2023-05-25 | ||
| JPWO2023106175A1 (pt) * | 2021-12-08 | 2023-06-15 | ||
| CN118541360A (zh) | 2021-12-08 | 2024-08-23 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
| US20240239807A1 (en) | 2022-08-05 | 2024-07-18 | Gilead Sciences, Inc. | Sars-cov2 main protease inhibitors |
| JP2025535043A (ja) | 2022-10-06 | 2025-10-22 | コーセプト セラピューティクス， インコーポレイテッド | グルココルチコイド受容体調節因子の製剤 |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
Family Cites Families (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3060084A (en) | 1961-06-09 | 1962-10-23 | Du Pont | Improved homogeneous, readily dispersed, pesticidal concentrate |
| US3299566A (en) | 1964-06-01 | 1967-01-24 | Olin Mathieson | Water soluble film containing agricultural chemicals |
| US3325503A (en) | 1965-02-18 | 1967-06-13 | Diamond Alkali Co | Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation |
| US3296272A (en) | 1965-04-01 | 1967-01-03 | Dow Chemical Co | Sulfinyl- and sulfonylpyridines |
| US4144050A (en) | 1969-02-05 | 1979-03-13 | Hoechst Aktiengesellschaft | Micro granules for pesticides and process for their manufacture |
| US3920442A (en) | 1972-09-18 | 1975-11-18 | Du Pont | Water-dispersible pesticide aggregates |
| US4172714A (en) | 1976-12-20 | 1979-10-30 | E. I. Du Pont De Nemours And Company | Dry compactible, swellable herbicidal compositions and pellets produced therefrom |
| GB2095558B (en) | 1981-03-30 | 1984-10-24 | Avon Packers Ltd | Formulation of agricultural chemicals |
| DE3338292A1 (de) | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide |
| CA1249832A (en) | 1984-02-03 | 1989-02-07 | Shionogi & Co., Ltd. | Azolyl cycloalkanol derivatives and agricultural fungicides |
| US5304732A (en) | 1984-03-06 | 1994-04-19 | Mgi Pharma, Inc. | Herbicide resistance in plants |
| BR8600161A (pt) | 1985-01-18 | 1986-09-23 | Plant Genetic Systems Nv | Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio |
| DE3545319A1 (de) | 1985-12-20 | 1987-06-25 | Basf Ag | Acrylsaeureester und fungizide, die diese verbindungen enthalten |
| ATE57390T1 (de) | 1986-03-11 | 1990-10-15 | Plant Genetic Systems Nv | Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen. |
| US4670560A (en) * | 1986-04-28 | 1987-06-02 | Ortho Pharmaceutical Corporation | Thienopyrimidine-2,4-dione derivatives and intermediates thereof |
| CN1015981B (zh) | 1986-05-02 | 1992-03-25 | 施托福化学公司 | 吡啶基亚胺酸酯的制备方法 |
| DE256503T1 (de) | 1986-08-12 | 1990-02-08 | Mitsubishi Kasei Corp., Tokio/Tokyo | Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel. |
| FR2629098B1 (fr) | 1988-03-23 | 1990-08-10 | Rhone Poulenc Agrochimie | Gene chimerique de resistance herbicide |
| US5180587A (en) | 1988-06-28 | 1993-01-19 | E. I. Du Pont De Nemours And Company | Tablet formulations of pesticides |
| EP0374753A3 (de) | 1988-12-19 | 1991-05-29 | American Cyanamid Company | Insektizide Toxine, Gene, die diese Toxine kodieren, Antikörper, die sie binden, sowie transgene Pflanzenzellen und transgene Pflanzen, die diese Toxine exprimieren |
| JPH02225485A (ja) * | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | チエノピリミジン―３―酢酸誘導体 |
| ES2199931T3 (es) | 1989-03-24 | 2004-03-01 | Syngenta Participations Ag | Plantas transgenicas resistentes a enfermedades. |
| ZW13690A1 (en) | 1989-08-30 | 1990-11-21 | Aeci Ltd | Active ingredient dosage device |
| ES2074547T3 (es) | 1989-11-07 | 1995-09-16 | Pioneer Hi Bred Int | Lectinas larvicidas, y resistencia inducida de las plantas a los insectos. |
| AU628229B2 (en) | 1989-11-10 | 1992-09-10 | Agro-Kanesho Co. Ltd. | Hexahydrotriazine compounds and insecticides |
| AU651335B2 (en) | 1990-03-12 | 1994-07-21 | E.I. Du Pont De Nemours And Company | Water-dispersible or water-soluble pesticide granules from heat-activated binders |
| WO1992000377A1 (en) | 1990-06-25 | 1992-01-09 | Monsanto Company | Glyphosate tolerant plants |
| EP0480679B1 (en) | 1990-10-11 | 1996-09-18 | Sumitomo Chemical Company Limited | Pesticidal composition |
| JP2828186B2 (ja) | 1991-09-13 | 1998-11-25 | 宇部興産株式会社 | アクリレート系化合物、その製法及び殺菌剤 |
| UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| DE4322211A1 (de) | 1993-07-03 | 1995-01-12 | Basf Ag | Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung |
| TW276256B (pt) * | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
| JP3811196B2 (ja) * | 1993-08-26 | 2006-08-16 | 武田薬品工業株式会社 | エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法 |
| US5530195A (en) | 1994-06-10 | 1996-06-25 | Ciba-Geigy Corporation | Bacillus thuringiensis gene encoding a toxin active against insects |
| JPH09110873A (ja) * | 1995-08-17 | 1997-04-28 | Takeda Chem Ind Ltd | チエノピリミジン誘導体、その製造法および用途 |
| CA2227384A1 (en) | 1995-08-17 | 1997-02-27 | Toshifumi Watanabe | Thienopyrimidine derivatives, their production and use |
| US5773704A (en) | 1996-04-29 | 1998-06-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Herbicide resistant rice |
| CA2250908C (en) | 1996-04-30 | 2012-03-13 | Takeda Chemical Industries, Ltd. | Combined use of gnrh agonist and antagonist |
| JP2007302703A (ja) * | 1996-04-30 | 2007-11-22 | Takeda Chem Ind Ltd | 医薬組成物 |
| AU3596697A (en) | 1996-07-17 | 1998-02-09 | Michigan State University | Imidazolinone herbicide resistant sugar beet plants |
| US5773702A (en) | 1996-07-17 | 1998-06-30 | Board Of Trustees Operating Michigan State University | Imidazolinone herbicide resistant sugar beet plants |
| DE19650197A1 (de) | 1996-12-04 | 1998-06-10 | Bayer Ag | 3-Thiocarbamoylpyrazol-Derivate |
| TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| SE9702001D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| US6984644B2 (en) * | 1997-05-28 | 2006-01-10 | Astrazeneca Ab | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones |
| NZ503594A (en) | 1997-09-18 | 2001-08-31 | Basf Ag | (Phenyl, thienyl or pyrazolyl)-substituted and alkyl-substituted benzamidoxime derivatives, and benzonitrile intermediates, useful as fungicides |
| DE19750012A1 (de) | 1997-11-12 | 1999-05-20 | Bayer Ag | Isothiazolcarbonsäureamide |
| AU1621799A (en) | 1997-12-04 | 1999-06-16 | Dow Agrosciences Llc | Fungicidal compositions and methods, and compounds and methods for the preparation thereof |
| DE19754082A1 (de) * | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
| US6348643B1 (en) | 1998-10-29 | 2002-02-19 | American Cyanamid Company | DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use |
| AU755538B2 (en) | 1998-11-17 | 2002-12-12 | Ihara Chemical Industry Co. Ltd. | Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural fungicides |
| IT1303800B1 (it) | 1998-11-30 | 2001-02-23 | Isagro Ricerca Srl | Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico. |
| JP3417862B2 (ja) | 1999-02-02 | 2003-06-16 | 新東工業株式会社 | 酸化チタン光触媒高担持シリカゲルおよびその製造方法 |
| AU770077B2 (en) | 1999-03-11 | 2004-02-12 | Dow Agrosciences Llc | Heterocyclic substituted isoxazolidines and their use as fungicides |
| EP1171442B1 (en) | 1999-04-09 | 2005-12-07 | Cell Therapeutics, Inc. | Xanthine derivatives and analogs as cell signalling inhibitors |
| US6586617B1 (en) | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
| UA73307C2 (uk) | 1999-08-05 | 2005-07-15 | Куміаі Кемікал Індастрі Ко., Лтд. | Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення |
| DE10021412A1 (de) | 1999-12-13 | 2001-06-21 | Bayer Ag | Fungizide Wirkstoffkombinationen |
| DK1250047T3 (da) | 2000-01-25 | 2005-05-30 | Syngenta Participations Ag | Herbicidt middel |
| US6376548B1 (en) | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
| IL167957A (en) | 2000-02-04 | 2009-07-20 | Sumitomo Chemical Co | Hydroxypyridine compounds |
| MX233208B (es) | 2000-04-28 | 2005-12-20 | Basf Ag | Uso del gen mutante ahas 2 del maiz xi12 y herbicidas de imidazolinona para la seleccion de plantas de maiz, arroz y trigo, monocotiledoneas transgenicas, resistentes a los herbicidas de imidazolinona. |
| CN100353846C (zh) | 2000-08-25 | 2007-12-12 | 辛根塔参与股份公司 | 新的来自苏云金芽孢杆菌杀虫晶体蛋白的杀虫毒素 |
| MXPA03002338A (es) | 2000-09-18 | 2003-09-10 | Du Pont | Piridinilamidas y piridinilimidas para uso como fungicidas. |
| NZ525744A (en) | 2000-11-17 | 2004-10-29 | Dow Agrosciences Llc | Compounds having fungicidal activity and processes to make and use same |
| EP1370562A1 (en) | 2001-02-14 | 2003-12-17 | Warner-Lambert Company LLC | Thieno[2,3-d]pyrimidindione derivatives as matrix metalloproteinase inhibitors |
| JP5034142B2 (ja) | 2001-04-20 | 2012-09-26 | 住友化学株式会社 | 植物病害防除剤組成物 |
| DE10136065A1 (de) | 2001-07-25 | 2003-02-13 | Bayer Cropscience Ag | Pyrazolylcarboxanilide |
| AR037228A1 (es) | 2001-07-30 | 2004-11-03 | Dow Agrosciences Llc | Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada |
| FR2828196A1 (fr) | 2001-08-03 | 2003-02-07 | Aventis Cropscience Sa | Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture |
| ES2417012T3 (es) | 2001-08-09 | 2013-08-05 | Northwest Plant Breeding Co. | Plantas de trigo que exhiben resistencia aumentada a los herbicidas de imidazolinona |
| RU2337532C2 (ru) | 2001-08-09 | 2008-11-10 | Юниверсити Оф Саскачеван | Растения пшеницы с повышенной устойчивостью к имидазолиноновым гербицидам |
| US7897845B2 (en) | 2001-08-09 | 2011-03-01 | University Of Saskatchewan | Wheat plants having increased resistance to imidazolinone herbicides |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| JPWO2003016286A1 (ja) | 2001-08-17 | 2004-12-02 | 三共アグロ株式会社 | ３−フェノキシ−４−ピリダジノール誘導体及びそれを含有する除草剤組成物 |
| US7230167B2 (en) | 2001-08-31 | 2007-06-12 | Syngenta Participations Ag | Modified Cry3A toxins and nucleic acid sequences coding therefor |
| WO2003052073A2 (en) | 2001-12-17 | 2003-06-26 | Syngenta Participations Ag | Novel corn event |
| WO2003053145A1 (en) | 2001-12-21 | 2003-07-03 | Nissan Chemical Industries, Ltd. | Bactericidal composition |
| TWI327462B (en) | 2002-01-18 | 2010-07-21 | Sumitomo Chemical Co | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same |
| DE10204390A1 (de) | 2002-02-04 | 2003-08-14 | Bayer Cropscience Ag | Disubstituierte Thiazolylcarboxanilide |
| PL372887A1 (en) * | 2002-02-27 | 2005-08-08 | Pfizer Products Inc. | Acc inhibitors |
| HK1079785B (zh) | 2002-03-05 | 2007-08-10 | 辛根塔参与股份公司 | 邻环丙基-n-甲酰苯胺及其作为杀菌剂的用途 |
| EP1551218B1 (en) | 2002-07-10 | 2017-05-17 | The Department of Agriculture, Western Australia | Wheat plants having increased resistance to imidazolinone herbicides |
| AU2003253165A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| GB0227966D0 (en) | 2002-11-29 | 2003-01-08 | Syngenta Participations Ag | Organic Compounds |
| DE602004020052D1 (de) | 2003-01-06 | 2009-04-30 | Israel State | Pflanzliche acetyl-coa carboxylase-hemmende herbizide als pestizide |
| CA2514407C (en) * | 2003-01-29 | 2012-01-03 | Takeda Pharmaceutical Company Limited | Thienopyrimidine compounds and use thereof |
| WO2004083193A1 (ja) | 2003-03-17 | 2004-09-30 | Sumitomo Chemical Company, Limited | アミド化合物およびこれを含有する殺菌剤組成物 |
| MXPA05012733A (es) | 2003-05-28 | 2006-05-17 | Basf Ag | Plantas de trigo que tienen tolerancia incrementada a los herbicidas de imidazolinona. |
| ES2743420T3 (es) | 2003-08-29 | 2020-02-19 | Instituto Nac De Tecnologia Agropecuaria | Plantas de arroz que tienen tolerancia incrementada frente a herbicidas de imidazolinona |
| TWI355894B (en) | 2003-12-19 | 2012-01-11 | Du Pont | Herbicidal pyrimidines |
| HRP20100538T1 (hr) | 2004-03-10 | 2010-12-31 | Basf Se | 5,6-dialkil-7-aminotriazolopirimidini, postupci za njihovo dobijanje, njihova primjena za kontrolu patogenih gljiva, kao i sredstva koja sadrže spomenute spojeve |
| JP2007527886A (ja) | 2004-03-10 | 2007-10-04 | ビーエーエスエフ アクチェンゲゼルシャフト | ５，６−ジアルキル−７−アミノトリアゾロピリミジン、その調製、および有害真菌を防除するためのその使用、ならびにそれらの化合物を含む組成物 |
| WO2005120234A2 (en) | 2004-06-03 | 2005-12-22 | E.I. Dupont De Nemours And Company | Fungicidal mixtures of amidinylphenyl compounds |
| EP1761498A1 (de) | 2004-06-18 | 2007-03-14 | Basf Aktiengesellschaft | 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid |
| ATE458722T1 (de) | 2004-06-18 | 2010-03-15 | Basf Se | 1-methyl-3-trifluormethyl-pyrazol-4-carbonsäure (ortho-phenyl)-anilide und ihre verwendung als fungizid |
| WO2006014647A2 (en) * | 2004-07-21 | 2006-02-09 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
| GB0418048D0 (en) | 2004-08-12 | 2004-09-15 | Syngenta Participations Ag | Method for protecting useful plants or plant propagation material |
| WO2006087325A1 (de) | 2005-02-16 | 2006-08-24 | Basf Aktiengesellschaft | 5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
| DE102005007160A1 (de) | 2005-02-16 | 2006-08-24 | Basf Ag | Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen |
| DE102005009458A1 (de) | 2005-03-02 | 2006-09-07 | Bayer Cropscience Ag | Pyrazolylcarboxanilide |
| PL1973881T3 (pl) | 2006-01-13 | 2010-04-30 | Dow Agrosciences Llc | 6-(wielo-podstawione arylo)-4-aminopikoliniany i ich zastosowanie jako herbicydy |
| EP1983832A2 (en) | 2006-02-09 | 2008-10-29 | Syngeta Participations AG | A method of protecting a plant propagation material, a plant, and/or plant organs |
| US20070208040A1 (en) * | 2006-03-02 | 2007-09-06 | Elfatih Elzein | A2a adenosine receptor antagonists |
| JPWO2008143262A1 (ja) * | 2007-05-21 | 2010-08-12 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP5535931B2 (ja) * | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| HRP20140035T1 (hr) * | 2009-12-29 | 2014-02-14 | Poxel | Tieno[2,3-b]piridindion aktivatori ampk i njihove terapijske uporabe |
| LT2776038T (lt) | 2011-11-11 | 2018-04-25 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
| US9988399B2 (en) * | 2013-05-10 | 2018-06-05 | Gilead Apollo, Llc | Bicyclic compounds as ACC inhibitors and uses thereof |
| AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| EA201890913A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | Пиразоловые соединения в качестве ингибиторов акк и их применение |
| MX2018006287A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc de triazol y usos de los mismos. |
| CN108347939B (zh) | 2015-11-25 | 2021-09-28 | 吉利德阿波罗公司 | 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物 |
| WO2017091602A1 (en) | 2015-11-25 | 2017-06-01 | Gilead Apollo, Llc | Ester acc inhibitors and uses thereof |
| BR112018067408A2 (pt) | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
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