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HRP20180534T1 - Acc inhibitori i njihove primjene - Google Patents

Acc inhibitori i njihove primjene Download PDF

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Publication number
HRP20180534T1
HRP20180534T1 HRP20180534TT HRP20180534T HRP20180534T1 HR P20180534 T1 HRP20180534 T1 HR P20180534T1 HR P20180534T T HRP20180534T T HR P20180534TT HR P20180534 T HRP20180534 T HR P20180534T HR P20180534 T1 HRP20180534 T1 HR P20180534T1
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Croatia
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sulfur
nitrogen
oxygen
independently selected
so2r
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HRP20180534TT
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English (en)
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Geraldine C. Harriman
Craig E. Masse
James Harwood
Sathesh Bhat
Jeremy Robert Greenwood
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Gilead Apollo, Llc
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Publication of HRP20180534T1 publication Critical patent/HRP20180534T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (10)

1. Spoj sa formulom II: [image] ili njegova farmaceutski prihvatljiva sol, gdje: R1 je vodik ili C1-4 alifatična grupa, po izboru supstituirana sa jednim ili više halogena, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, ili -SO2R; R2 je Hy, gdje Hy je odabran od zasićenog ili djelomično nezasićenog monocikličnog heterocikličnog prstena sa 4-8 članova koji ima 1-2 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, monocikličnog heteroaromatičnog prstena sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, ili bicikličnog heteroaromatičnog prstena sa 8-10 članova koji ima 1-5 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; svaki R je nezavisno vodik ili po izboru supstituirana grupa odabrana od C1-6 alifatične grupe, zasićenog ili djelomično nezasićenog monocikličnog karbocikličnog prstena sa 3-8 članova, fenil grupe, bicikličnog aromatičnog karbocikličnog prstena sa 8-10 članova; zasićeni ili djelomično nezasićeni monociklični heterociklični prsten sa 4-8 članova koji ima 1-2 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, monociklični heteroaromatični prsten sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, ili biciklični heteroaromatični prsten sa 8-10 članova koji ima 1-5 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; R3 je vodik, halogen, -CN, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, -SO2R, -B(OH)2, ili po izboru supstituiran prsten odabran od fenila ili heteroarila sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; R4 je po izboru supstituiran fenil ili naftil prsten; svaki od R5 i R5' je nezavisno -R, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, ili -SO2R; ili R5 i R5' su uzeti zajedno da formiraju ciklopropilenil, ciklobutilenil, ili oksetanil grupu; i svaki od R7 i R7' je nezavisno vodik, -R, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, ili -SO2R; ili R7 i R7' su uzeti zajedno da formiraju zasićen ili djelomično nezasićen monociklični karbociklični prsten sa 3-8 članova, ili zasićen ili djelomično nezasićen monociklični heterociklični prsten sa 4-8 članova koji ima 1-2 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora.
2. Spoj sa formulom III: [image] ili njegova farmaceutski prihvatljiva sol, gdje: R1 je vodik ili C1-4 alifatična grupa, po izboru supstituirana sa jednim ili više halogena, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, ili -SO2R; R2 je Hy, gdje Hy je odabran od zasićenog ili djelomično nezasićenog monocikličnog heterocikličnog prstena sa 4-8 članova koji ima 1-2 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, monocikličnog heteroaromatičnog prstena sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, ili bicikličnog heteroaromatičnog prstena sa 8-10 članova koji ima 1-5 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; svaki R je nezavisno vodik ili po izboru supstituirana grupa odabrana od C1-6 alifatične grupe, zasićenog ili djelomično nezasićenog monocikličnog karbocikličnog prstena sa 3-8 članova, fenil grupe, bicikličnog aromatičnog karbocikličnog prstena sa 8-10 članova; zasićeni ili djelomično nezasićeni monociklični heterociklični prsten sa 4-8 članova koji ima 1-2 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, monociklični heteroaromatični prsten sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, ili biciklični heteroaromatični prsten sa 8-10 članova koji ima 1-5 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; R3 je vodik, halogen, -CN, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, -SO2R, -B(OH)2, ili po izboru supstituiran prsten odabran od fenila ili heteroarila sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; svaki od R5 i R5' je nezavisno -R, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, ili -SO2R; ili R5 i R5' su uzeti zajedno da formiraju ciklopropilenil, ciklobutilenil, ili oksetanil grupu; R6 je -R, -C(O)N(R)2, ili -C(O)R; svaki R8 je nezavisno odabran od halogena, -R, -OR, -SR, -N(R)2 ili deuterija; i n je 0-5.
3. Spoj sa formulom IV: [image] ili njegova farmaceutski prihvatljiva sol, gdje: R1 je vodik ili C1-4 alifatična grupa, po izboru supstituirana sa jednim ili više halogena, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, ili -SO2R; R2 je Hy, gdje Hy je odabran od zasićenog ili djelomično nezasićenog monocikličnog heterocikličnog prstena sa 4-8 članova koji ima 1-2 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, monocikličnog heteroaromatičnog prstena sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, ili bicikličnog heteroaromatičnog prstena sa 8-10 članova koji ima 1-5 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; svaki R je nezavisno vodik ili po izboru supstituirana grupa odabrana od C1-6 alifatične grupe, zasićenog ili djelomično nezasićenog monocikličnog karbocikličnog prstena sa 3-8 članova, fenil grupe, bicikličnog aromatičnog karbocikličnog prstena sa 8-10 članova; zasićeni ili djelomično nezasićeni monociklični heterociklični prsten sa 4-8 članova koji ima 1-2 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, monociklični heteroaromatični prsten sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora, ili biciklični heteroaromatični prsten sa 8-10 članova koji ima 1-5 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; R3 je vodik, halogen, -CN, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, -SO2R, -B(OH)2, ili po izboru supstituiran prsten odabran od fenila ili heteroarila sa 5-6 članova koji ima 1-4 heteroatoma nezavisno odabrana od dušika, kisika, ili sumpora; svaki od R5 i R5' je nezavisno -R, -OR, -SR, -N(R)2, -N(R)C(O)R, -C(O)N(R)2, -N(R)C(O)N(R)2, -N(R)C(O)OR, -OC(O)N(R)2, -N(R)SO2R, -SO2N(R)2, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, ili -SO2R; ili R5 i R5 su uzeti zajedno da formiraju ciklopropilenil, ciklobutilenil, ili oksetanil grupu; R6 je -R, -C(O)N(R)2, ili -C(O)R; svaki R8 je nezavisno odabran od halogena, -R, -OR, -SR, -N(R)2 ili deuterija; i n je 0-5.
4. Spoj u skladu sa bilo kojim od patentnih zahtjeva 1, 2, ili 3, gdje R1 je metil ili trifluorometil.
5. Spoj u skladu sa bilo kojim od patentnih zahtjeva 1, 2, 3, ili 4, gdje R2 je oksazolil.
6. Spoj u skladu sa bilo kojim od patentnih zahtjeva 1, 2, 3, ili 4, gdje R3 je tetrazolil, -C(O)OR, -C(O)N(R)2, ili -OR.
7. Spoj bilo kog od patentnih zahtjeva 1, 2, 3, 4, 5, ili 6, gdje R5 i R5 su svaki metil, ili njegova farmaceutski prihvatljiva sol.
8. Spoj u skladu sa bilo kojim od patentnih zahtjeva 1, 2, 3, 4, 5, 6, ili 7, gdje R3 je -C(O)OR ili -C(O)N(R)2, ili njegova farmaceutski prihvatljiva sol.
9. Spoj u skladu sa bilo kojim od patentnih zahtjeva 1, 2, 3, 4, 5, 6, ili 7, gdje R3 je -C(O)OH, ili njegova farmaceutski prihvatljiva sol.
10. Kompozicija koja sadrži spoj u skladu sa bilo kojim od patentnih zahtjeva 1, 2, 3, 4, 5, 6, 7, 8, ili 9, i farmaceutski prihvatljiv nosač, katalizator, ili vehikulum.
HRP20180534TT 2011-11-11 2012-11-09 Acc inhibitori i njihove primjene HRP20180534T1 (hr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161559023P 2011-11-11 2011-11-11
US201261615092P 2012-03-23 2012-03-23
US201261651878P 2012-05-25 2012-05-25
US201261675513P 2012-07-25 2012-07-25
EP12848361.7A EP2776038B1 (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof
PCT/US2012/064528 WO2013071169A1 (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof

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HRP20180534T1 true HRP20180534T1 (hr) 2018-05-04

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HRP20180534TT HRP20180534T1 (hr) 2011-11-11 2012-11-09 Acc inhibitori i njihove primjene
HRP20192202TT HRP20192202T1 (hr) 2011-11-11 2019-12-06 Acc inhibitori i njihove upotrebe

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US (5) US8969557B2 (hr)
EP (3) EP2776038B1 (hr)
JP (4) JP6114297B2 (hr)
KR (3) KR102033806B1 (hr)
CN (3) CN106905346B (hr)
AU (3) AU2012335088B2 (hr)
BR (2) BR112014011351B1 (hr)
CA (1) CA2855372C (hr)
CL (1) CL2014001241A1 (hr)
CY (2) CY1120224T1 (hr)
DK (2) DK3329919T3 (hr)
EA (2) EA033598B1 (hr)
ES (3) ES2665580T3 (hr)
HR (2) HRP20180534T1 (hr)
HU (2) HUE037444T2 (hr)
LT (2) LT3329919T (hr)
MX (3) MX390746B (hr)
PL (3) PL3628320T3 (hr)
PT (2) PT2776038T (hr)
RS (1) RS57157B1 (hr)
SI (2) SI2776038T1 (hr)
SM (1) SMT201800191T1 (hr)
TW (4) TWI655193B (hr)
UA (2) UA123760C2 (hr)
WO (1) WO2013071169A1 (hr)
ZA (3) ZA201403633B (hr)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
ES2665580T3 (es) * 2011-11-11 2018-04-26 Gilead Apollo, Llc Inhibidores de ACC y usos de los mismos
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EA027929B1 (ru) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Нуклеозиды на основе урацила и спирооксетана
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US9518050B2 (en) 2012-12-18 2016-12-13 Almirall, S.A. Cyclohexyl and quinuclidinyl carbamate derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activity
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
JP6434498B2 (ja) 2013-05-10 2018-12-05 ギリアド アポロ， エルエルシー Ａｃｃ阻害剤及びその使用
CN105358152A (zh) * 2013-05-10 2016-02-24 尼普斯阿波罗有限公司 Acc抑制剂和其用途
HK1221660A1 (zh) * 2013-05-10 2017-06-09 Gilead Apollo, Llc Acc抑制劑和其用途
BR112015028214A2 (pt) * 2013-05-10 2017-07-25 Nimbus Apollo Inc inibidores de acc e usos dos mesmos
WO2015003879A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicylic derivatives
WO2015003881A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015007451A1 (en) 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015007453A1 (en) * 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015010832A1 (en) * 2013-07-22 2015-01-29 Syngenta Participations Ag Microbiocidal heterocyclic derivatives
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
MX2016002479A (es) 2013-09-12 2016-05-31 Pfizer Uso de inhibidores de acetil-coa carboxilasa para tratar acne vulgaris.
TN2016000121A1 (en) 2013-10-07 2017-10-06 Bayer Pharma AG Cyclic thienouracil-carboxamides and use thereof
WO2015056782A1 (ja) 2013-10-17 2015-04-23 塩野義製薬株式会社 新規アルキレン誘導体
RU2674977C2 (ru) * 2013-10-30 2018-12-14 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Производные пиразолопиримидона или пирролотриазона, способ их получения и их фармацевтические применения
LT3083627T (lt) 2013-12-19 2018-12-27 Novartis Ag [1,2,4]triazolo[1,5-a]pirimidino dariniai kaip protozoano proteasomos inhibitoriai, skirti parazitinių ligų tokių kaip leišmaniozė, gydymui
WO2016023832A1 (en) * 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
CN105779463B (zh) * 2014-12-25 2019-08-09 深圳华大生命科学研究院 Vps13b基因突变体及其应用
EA201791258A1 (ru) * 2015-01-09 2017-12-29 Джилид Аполло, Ллс Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
US11078259B2 (en) * 2015-06-05 2021-08-03 Joslin Diabetes Center, Inc. Methods and compositions for promoting thermogenic potential
CN105009933B (zh) * 2015-06-10 2018-08-14 邓娟 一种以通风曲方式栽培草菇的工艺
CN107922390B (zh) 2015-07-06 2019-05-10 吉利德科学公司 Cot调节剂及其使用方法
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
KR20180082557A (ko) * 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 트리아졸 acc 억제제 및 그의 용도
PL3379933T3 (pl) * 2015-11-25 2023-07-24 Gilead Apollo, Llc KOMPOZYCJE GRZYBOBÓJCZE ZAWIERAJĄCE POCHODNE 2,4-DIOKSO-1,4-DIHYDROTIENO[2,3-d]PIRYMIDYNY
ES2939833T3 (es) * 2015-11-25 2023-04-27 Gilead Apollo Llc Inhibidores de ACC de pirazol y usos de los mismos
EA201890949A1 (ru) 2015-11-25 2018-12-28 Джилид Аполло, Ллс СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
US10973825B2 (en) 2015-12-09 2021-04-13 Cadent Therapeutics, Inc. Thienopyrimidinone NMDA receptor modulators and uses thereof
JP7071917B2 (ja) 2015-12-09 2022-05-19 カデント セラピューティクス，インコーポレーテッド ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用
WO2017147161A1 (en) * 2016-02-23 2017-08-31 Raju Mohan Treatment of dermatological disorders or conditions
CA3155220C (en) * 2016-03-02 2024-01-16 Gilead Apollo, Llc Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
CN107629071B (zh) * 2016-07-19 2019-12-27 上海勋和医药科技有限公司 取代2，4-（1h,3h）嘧啶二酮作为parp抑制剂及其应用
WO2018041771A1 (de) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung
US20200016159A1 (en) 2016-09-23 2020-01-16 Bayer Aktiengesellschaft N3-cyclically substituted thienouracils and use thereof
JP7332472B2 (ja) 2016-12-22 2023-08-23 ノバルティス アーゲー Ｎｍｄａ受容体モジュレーターおよびその使用
US10759812B2 (en) 2017-01-22 2020-09-01 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
CA3137479A1 (en) * 2017-03-03 2018-09-07 Gilead Sciences, Inc. Processes for preparing acc inhibitors and solid forms thereof
EP3589635A1 (en) * 2017-03-03 2020-01-08 Gilead Apollo, LLC Processes for the preparation of fungicidal compounds
WO2018171699A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途
WO2018171698A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物及其制备方法和用途
EP3600310A1 (en) 2017-03-28 2020-02-05 Gilead Sciences, Inc. Methods of treating liver disease
AU2018243719B2 (en) 2017-03-28 2021-01-21 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases
JP7563882B2 (ja) 2017-03-31 2024-10-08 コーセプト セラピューティクス， インコーポレイテッド 子宮頸がんを処置するためのグルココルチコイドレセプターモジュレーター
US20180333401A1 (en) 2017-04-12 2018-11-22 Gilead Sciences, Inc. Methods of treating liver disease
CN107151251A (zh) * 2017-05-10 2017-09-12 江苏开元药业有限公司 一种acc抑制剂药物关键中间体的制备方法
WO2018231851A1 (en) 2017-06-13 2018-12-20 Gilead Sciences, Inc. Methods of treating liver fibrosis
CN110709402B (zh) * 2017-06-15 2022-05-10 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
CN111201234A (zh) * 2017-07-17 2020-05-26 南京瑞捷医药科技有限公司 新型化合物及其作为acc抑制剂的用途
US11186587B2 (en) 2017-07-26 2021-11-30 Nanjing Sanhome Pharmaceutical Co., Ltd. Compound as ACC inhibitor and use thereof
TW201910334A (zh) * 2017-07-28 2019-03-16 大陸商江蘇恆瑞醫藥股份有限公司 一種嘧啶酮并雜芳基類衍生物的製備方法及其中間體
JPWO2019031384A1 (ja) * 2017-08-07 2020-07-09 日本曹達株式会社 １，３，５，６−テトラ置換チエノ［２，３−ｄ］ピリミジン−２，４（１Ｈ，３Ｈ）ジオン化合物および農園芸用殺菌剤
KR20190036705A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체
AU2018345817B2 (en) 2017-10-06 2021-10-28 Gilead Sciences, Inc. Combination therapy comprising an ACC inhibitor
WO2019072478A1 (en) 2017-10-10 2019-04-18 Galderma Research & Development SPECIFIC ACETYL-COA CARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT AND / OR PREVENTION OF ACNE
ES2986647T3 (es) 2017-11-13 2024-11-12 Gilead Sciences Inc Método de estadificación de la fibrosis hepática en pacientes con EHNA
CN108129251A (zh) * 2017-12-22 2018-06-08 上海应用技术大学 一种2-乙基苯乙烯的合成工艺
ES2986922T3 (es) 2018-06-05 2024-11-13 Medshine Discovery Inc Derivado de tieno[2,3-c]piridazin-4(1H)-ona y aplicación del mismo
MA53351B1 (fr) 2018-08-03 2023-08-31 Novartis Ag Modulateurs des récepteurs nmda hétéroaromatiques et leurs utilisations
CN110950884B (zh) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
JP2022513101A (ja) * 2018-11-20 2022-02-07 中国医▲薬▼研究▲開▼▲発▼中心有限公司 スピロ環系化合物及びその医薬用途
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
CN117281790A (zh) 2018-12-19 2023-12-26 科塞普特治疗公司 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
EP3669652A1 (en) 2018-12-21 2020-06-24 Bayer AG Active compound combination
SG11202107434PA (en) 2019-01-15 2021-08-30 Gilead Sciences Inc Fxr (nr1h4) modulating compounds
CN111484504B (zh) * 2019-01-25 2024-05-10 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
KR20250076696A (ko) 2019-02-22 2025-05-29 코어셉트 쎄라퓨틱스 인코포레이티드 헤테로아릴-케톤 융합 아자데칼린 글루코코르티코이드 수용체 조절제인 렐라코릴란트의 치료 용도
CA3132044A1 (en) 2019-03-11 2020-09-17 Brian Kirby Formulations of a compound and uses thereof
CN111747916A (zh) * 2019-03-27 2020-10-09 尚科生物医药（上海）有限公司 (r)-2-(2-甲氧基苯基)-2-(四氢吡喃-4-氧基)乙-1-醇的制备方法
CN109810085B (zh) * 2019-04-19 2019-07-19 上海皓元生物医药科技有限公司 Acc抑制剂及其中间体的制备方法
CN111850061B (zh) * 2019-04-30 2022-12-09 浙江工业大学 一种井冈羟胺a酯化物的制备方法
CN110343650B (zh) * 2019-05-28 2020-12-29 浙江工业大学 一种产两性霉素b的重组结节链霉菌及其应用
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
WO2020255946A1 (ja) * 2019-06-17 2020-12-24 日本曹達株式会社 ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物及び農園芸用殺菌剤
WO2021000242A1 (zh) 2019-07-02 2021-01-07 广东东阳光药业有限公司 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用
AR119594A1 (es) * 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
US20220347190A1 (en) 2019-09-19 2022-11-03 Novartis Ag Treatment comprising fxr agonists
CN112574253B (zh) * 2019-09-29 2021-08-27 上海喀露蓝科技有限公司 磷酸或磷酸酯类衍生物、其制备方法及其在医药上的用途
CN110746439B (zh) * 2019-10-18 2020-10-30 南京瑞捷医药科技有限公司 一种噻吩并嘧啶二酮化合物的制备方法
PH12022551004A1 (en) 2019-10-28 2023-03-13 Nippon Soda Co 2,6-dioxo-3,6-dihydropyrimidine compound, agricultural and horticultural bactericide, nematicide, and medical and veterinary antifungal agent
CN112778325A (zh) * 2019-11-07 2021-05-11 南京瑞捷医药科技有限公司 一种acc抑制剂及其用途
JP7431961B2 (ja) 2019-11-15 2024-02-15 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニストとしてのトリアゾールカルバメートピリジルスルホンアミド及びその使用
WO2021112213A1 (ja) * 2019-12-05 2021-06-10 日本曹達株式会社 ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤
US11673899B2 (en) 2019-12-05 2023-06-13 Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. Crystal form of thieno[2,3-c]pyridazine-4(1H)-one compound, preparation method therefor and use thereof
US11578081B1 (en) 2019-12-05 2023-02-14 Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof
KR20220113767A (ko) 2019-12-11 2022-08-16 코어셉트 쎄라퓨틱스 인코포레이티드 미리코릴란트로 항정신병약-유도 체중 증가를 치료하는 방법
CN115397511A (zh) 2020-03-30 2022-11-25 吉利德科学公司 Cot抑制剂化合物(s)-6-(((1-(双环[1.1.1]戊-1-基)-1h-1,2,3-三唑-4-基)2-甲基-1-氧代-1,2-二氢异喹啉-5-基)甲基)))氨基8-氯-(新戊基氨基)喹啉-3-甲腈的固体形式
CN115397824B (zh) 2020-04-02 2024-10-22 吉利德科学公司 用于制备cot抑制剂化合物的方法
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN111513022B (zh) * 2020-05-08 2021-11-12 武汉市农业科学院 一种低皮脂率的小体型肉鸭的选育方法
US20230210822A1 (en) 2020-05-21 2023-07-06 Shionogi & Co., Ltd. Pharmaceutical composition for treating fatty liver disease
TWI838626B (zh) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
AU2021282986B2 (en) 2020-06-03 2024-03-07 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
CN113968871A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 苯基取代类acc抑制剂的晶型
CN113967213A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 一种包含苯基取代类acc抑制剂的组合物及其用途
CN111888349B (zh) * 2020-07-29 2021-10-22 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 印楝素在制备促进缺血超长随意皮瓣存活药物的作用
WO2022134033A1 (en) 2020-12-25 2022-06-30 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
TW202233632A (zh) * 2021-02-07 2022-09-01 大陸商正大天晴藥業集團股份有限公司 噻吩并嘧啶衍生物
EP4304711A1 (en) 2021-03-11 2024-01-17 Gilead Sciences, Inc. Glp-1r modulating compounds
JP7705475B2 (ja) 2021-03-29 2025-07-09 ギリアード サイエンシーズ， インコーポレイテッド Ｋｈｋ阻害剤
EP4344545A4 (en) 2021-04-28 2025-03-26 Nippon Soda Co., Ltd. AGRICULTURAL AND HORTICULTURAL FUNGICIDE COMPOSITION
WO2022240879A1 (en) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
EP4337654A1 (en) 2021-05-13 2024-03-20 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
TW202345826A (zh) 2021-06-04 2023-12-01 美商基利科學股份有限公司 治療nash之方法
TW202311256A (zh) 2021-06-18 2023-03-16 美商基利科學股份有限公司 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑
WO2023090411A1 (ja) 2021-11-19 2023-05-25 塩野義製薬株式会社 心疾患または骨格筋の疾患の治療用医薬
CA3238094A1 (en) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
JPWO2023106175A1 (hr) * 2021-12-08 2023-06-15
US20240239807A1 (en) 2022-08-05 2024-07-18 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3325503A (en) 1965-02-18 1967-06-13 Diamond Alkali Co Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en) 1965-04-01 1967-01-03 Dow Chemical Co Sulfinyl- and sulfonylpyridines
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
DE3338292A1 (de) 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
CA1249832A (en) 1984-02-03 1989-02-07 Shionogi & Co., Ltd. Azolyl cycloalkanol derivatives and agricultural fungicides
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
BR8600161A (pt) 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
DE3545319A1 (de) 1985-12-20 1987-06-25 Basf Ag Acrylsaeureester und fungizide, die diese verbindungen enthalten
EP0242236B2 (en) 1986-03-11 1996-08-21 Plant Genetic Systems N.V. Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering
US4670560A (en) * 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
CN1015981B (zh) 1986-05-02 1992-03-25 施托福化学公司 吡啶基亚胺酸酯的制备方法
CA1293975C (en) 1986-08-12 1992-01-07 Naoko Sasaki Pyridinecarboxamide derivatives and their use as fungicide
FR2629098B1 (fr) 1988-03-23 1990-08-10 Rhone Poulenc Agrochimie Gene chimerique de resistance herbicide
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
CA2005658A1 (en) 1988-12-19 1990-06-19 Eliahu Zlotkin Insecticidal toxins, genes encoding these toxins, antibodies binding to them and transgenic plant cells and plants expressing these toxins
JPH02225485A (ja) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk チエノピリミジン―３―酢酸誘導体
ATE241699T1 (de) 1989-03-24 2003-06-15 Syngenta Participations Ag Krankheitsresistente transgene pflanze
DK0777964T3 (da) 1989-08-30 2002-03-11 Kynoch Agrochemicals Proprieta Fremgangsmåde til fremstilling af et doseringssystem
DE69018772T2 (de) 1989-11-07 1996-03-14 Pioneer Hi Bred Int Larven abtötende Lektine und darauf beruhende Pflanzenresistenz gegen Insekten.
AU628229B2 (en) 1989-11-10 1992-09-10 Agro-Kanesho Co. Ltd. Hexahydrotriazine compounds and insecticides
DE69106349T2 (de) 1990-03-12 1995-06-01 Du Pont Wasserdispergierbare oder wasserlösliche pestizide granulate aus hitzeaktivierten bindemitteln.
EP0536330B1 (en) 1990-06-25 2002-02-27 Monsanto Technology LLC Glyphosate tolerant plants
EP0480679B1 (en) 1990-10-11 1996-09-18 Sumitomo Chemical Company Limited Pesticidal composition
JP2828186B2 (ja) 1991-09-13 1998-11-25 宇部興産株式会社 アクリレート系化合物、その製法及び殺菌剤
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
DE4322211A1 (de) 1993-07-03 1995-01-12 Basf Ag Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
TW276256B (hr) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
JP3811196B2 (ja) * 1993-08-26 2006-08-16 武田薬品工業株式会社 エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
JPH09110873A (ja) * 1995-08-17 1997-04-28 Takeda Chem Ind Ltd チエノピリミジン誘導体、その製造法および用途
ATE227726T1 (de) 1995-08-17 2002-11-15 Takeda Chemical Industries Ltd Thienopyrimidinderivate als endothelin antagonisten
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
EP0906115A1 (en) 1996-04-30 1999-04-07 Takeda Chemical Industries, Ltd. COMBINED USE OF GnRH AGONIST AND ANTAGONIST
JP2007302703A (ja) * 1996-04-30 2007-11-22 Takeda Chem Ind Ltd 医薬組成物
TR199900115T2 (xx) 1996-07-17 1999-04-21 Michigan State University �midazolinon herbiside dayan�kl� �eker pancar� bitkileri.
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
DE19650197A1 (de) 1996-12-04 1998-06-10 Bayer Ag 3-Thiocarbamoylpyrazol-Derivate
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6984644B2 (en) * 1997-05-28 2006-01-10 Astrazeneca Ab Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
SE9702001D0 (sv) 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
CN1246304C (zh) 1997-09-18 2006-03-22 巴斯福股份公司 用于制备苄胺肟衍生物的中间产物
DE19750012A1 (de) 1997-11-12 1999-05-20 Bayer Ag Isothiazolcarbonsäureamide
AU1621799A (en) 1997-12-04 1999-06-16 Dow Agrosciences Llc Fungicidal compositions and methods, and compounds and methods for the preparation thereof
DE19754082A1 (de) * 1997-12-05 1999-06-10 Knoll Ag Methode zur Bekämpfung der Fettleibigkeit
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
ATE305465T1 (de) 1998-11-17 2005-10-15 Kumiai Chemical Industry Co Pyrimidinylbenzimidazol- und triazinylbenzimidazol-derivate und agrikulte/hortikulte fungizide
IT1303800B1 (it) 1998-11-30 2001-02-23 Isagro Ricerca Srl Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico.
JP3417862B2 (ja) 1999-02-02 2003-06-16 新東工業株式会社 酸化チタン光触媒高担持シリカゲルおよびその製造方法
AU770077B2 (en) 1999-03-11 2004-02-12 Dow Agrosciences Llc Heterocyclic substituted isoxazolidines and their use as fungicides
CA2369981A1 (en) 1999-04-09 2000-10-19 Cell Therapeutics, Inc. Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same
US6586617B1 (en) 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
UA73307C2 (uk) 1999-08-05 2005-07-15 Куміаі Кемікал Індастрі Ко., Лтд. Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення
DE10021412A1 (de) 1999-12-13 2001-06-21 Bayer Ag Fungizide Wirkstoffkombinationen
PL202070B1 (pl) 2000-01-25 2009-05-29 Syngenta Participations Ag Selektywna kompozycja herbicydowa i sposób zwalczania rozwoju niepożądanych roślin w uprawach roślin użytkowych
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
IL167958A (en) 2000-02-04 2010-11-30 Sumitomo Chemical Co 2-thio 3-hydroxypyridine derivatives
AU5920601A (en) 2000-04-28 2001-11-12 American Cyanamid Co Use of the maize x112 mutant ahas 2 gene and imidazolinone herbicides for selection of transgenic monocots, maize, rice and wheat plants resistant to the imidazolinone herbicides
JP2004506432A (ja) 2000-08-25 2004-03-04 シンジェンタ・パティシペーションズ・アクチェンゲゼルシャフト Ｂａｃｉｌｌｕｓｔｈｕｒｉｎｇｉｅｎｓｉｓ殺虫性結晶タンパク質由来の新規殺虫性毒素
PL362006A1 (en) 2000-09-18 2004-10-18 E.I.Du Pont De Nemours And Company Pyridinyl amides and imides for use as fungicides
JP4280495B2 (ja) 2000-11-17 2009-06-17 ダウ アグロサイエンシィズ エルエルシー 殺真菌活性を有する化合物ならびにその製造方法と用途
BR0207216A (pt) * 2001-02-14 2004-03-09 Warner Lambert Co Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz
JP5034142B2 (ja) 2001-04-20 2012-09-26 住友化学株式会社 植物病害防除剤組成物
DE10136065A1 (de) 2001-07-25 2003-02-13 Bayer Cropscience Ag Pyrazolylcarboxanilide
AR037228A1 (es) 2001-07-30 2004-11-03 Dow Agrosciences Llc Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada
FR2828196A1 (fr) 2001-08-03 2003-02-07 Aventis Cropscience Sa Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture
AU2002320377B8 (en) 2001-08-09 2008-09-04 Northwest Plant Breeding Company Wheat plants having increased resistance to imidazolinone herbicides
UA104990C2 (uk) 2001-08-09 2014-04-10 Юніверсіті Оф Саскачеван Рослина пшениці з підвищеною резистентністю до імідазолінонових гербіцидів
ATE527363T1 (de) 2001-08-09 2011-10-15 Univ Saskatchewan Weizenpflanzen mit erhöhter resistenz gegenüber imidazolinon-herbiziden
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
KR100879693B1 (ko) 2001-08-17 2009-01-21 상꾜 아그로 가부시키가이샤 2-시클로프로필-6-메틸페놀
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
AU2002361696A1 (en) 2001-12-17 2003-06-30 Syngenta Participations Ag Novel corn event
WO2003053145A1 (fr) 2001-12-21 2003-07-03 Nissan Chemical Industries, Ltd. Composition bactericide
TWI327462B (en) 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (de) 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituierte Thiazolylcarboxanilide
HRP20040716A2 (en) * 2002-02-27 2005-02-28 Pfizer Products Inc. Acc inhibitors
DE60314600T2 (de) 2002-03-05 2007-12-27 Syngenta Participations Ag O-cyclopropyl-carboxanilide und ihre verwendung als fungizide
EP1551218B1 (en) 2002-07-10 2017-05-17 The Department of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
WO2004014916A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
GB0227966D0 (en) 2002-11-29 2003-01-08 Syngenta Participations Ag Organic Compounds
ES2324472T3 (es) * 2003-01-06 2009-08-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Herbicidas que inhiben la accion de acetil-coa carboxilasa en vegetales para su uso como pesticidas.
EP1591446B1 (en) * 2003-01-29 2013-03-06 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
WO2004083193A1 (ja) 2003-03-17 2004-09-30 Sumitomo Chemical Company, Limited アミド化合物およびこれを含有する殺菌剤組成物
EP1633875B1 (en) 2003-05-28 2012-05-02 Basf Se Wheat plants having increased tolerance to imidazolinone herbicides
ES2743420T3 (es) 2003-08-29 2020-02-19 Instituto Nac De Tecnologia Agropecuaria Plantas de arroz que tienen tolerancia incrementada frente a herbicidas de imidazolinona
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
AU2005221808B8 (en) 2004-03-10 2011-01-06 Basf Se 5,6-dialkyl-7-amino-triazolopyrimidines, method for their production, their use for controlling pathogenic fungi and agents containing said compounds
DE502005009861D1 (de) 2004-03-10 2010-08-19 Basf Se 5,6-dialkyl-7-amino-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
AU2005251750A1 (en) 2004-06-03 2005-12-22 E.I. Dupont De Nemours And Company Fungicidal mixtures of amidinylphenyl compounds
WO2005123690A1 (de) 2004-06-18 2005-12-29 Basf Aktiengesellschaft 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid
EP1761499B1 (de) 2004-06-18 2010-02-24 Basf Se 1-methyl-3-trifluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid
WO2006014647A2 (en) * 2004-07-21 2006-02-09 Athersys, Inc. Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof
GB0418048D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
CN101115754B (zh) 2005-02-16 2010-11-10 巴斯福股份公司 5-烷氧基烷基-6-烷基-7-氨基唑并嘧啶、其制备方法、其在防治病原性真菌中的用途以及包含所述物质的试剂
DE102005007160A1 (de) 2005-02-16 2006-08-24 Basf Ag Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
DE102005009458A1 (de) 2005-03-02 2006-09-07 Bayer Cropscience Ag Pyrazolylcarboxanilide
TWI396682B (zh) 2006-01-13 2013-05-21 Dow Agrosciences Llc ６-（經多重取代之芳基）-４-胺基吡啶甲酸酯及其作為除草劑之用途
BRPI0708036A2 (pt) 2006-02-09 2011-05-17 Syngenta Participations Ag método de proteção de material de propagação de planta, planta e/ou órgãos de planta
CA2644996A1 (en) 2006-03-02 2007-09-13 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
EP2151440A4 (en) * 2007-05-21 2010-10-20 Takeda Pharmaceutical Heterocyclic compound and use thereof
EP2351743A4 (en) 2008-10-27 2012-05-09 Takeda Pharmaceutical BICYCLIC COMPOUND
PL2519527T3 (pl) 2009-12-29 2014-06-30 Poxel Tieno[2,3-B]Pirydynodionowe aktywatory AMPK i ich zastosowanie terapeutyczne
ES2665580T3 (es) 2011-11-11 2018-04-26 Gilead Apollo, Llc Inhibidores de ACC y usos de los mismos
CN105358152A (zh) * 2013-05-10 2016-02-24 尼普斯阿波罗有限公司 Acc抑制剂和其用途
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
KR20180082557A (ko) 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 트리아졸 acc 억제제 및 그의 용도
EA201890949A1 (ru) 2015-11-25 2018-12-28 Джилид Аполло, Ллс СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
ES2939833T3 (es) 2015-11-25 2023-04-27 Gilead Apollo Llc Inhibidores de ACC de pirazol y usos de los mismos
PL3379933T3 (pl) 2015-11-25 2023-07-24 Gilead Apollo, Llc KOMPOZYCJE GRZYBOBÓJCZE ZAWIERAJĄCE POCHODNE 2,4-DIOKSO-1,4-DIHYDROTIENO[2,3-d]PIRYMIDYNY
CA3155220C (en) 2016-03-02 2024-01-16 Gilead Apollo, Llc Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof

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