[go: up one dir, main page]

PT2544663T - Formulações intravenosas de coenzima q10 (coq10) e métodos de uso da mesma - Google Patents

Formulações intravenosas de coenzima q10 (coq10) e métodos de uso da mesma

Info

Publication number
PT2544663T
PT2544663T PT117541375T PT11754137T PT2544663T PT 2544663 T PT2544663 T PT 2544663T PT 117541375 T PT117541375 T PT 117541375T PT 11754137 T PT11754137 T PT 11754137T PT 2544663 T PT2544663 T PT 2544663T
Authority
PT
Portugal
Prior art keywords
coq10
coenzyme
methods
intravenous formulations
intravenous
Prior art date
Application number
PT117541375T
Other languages
English (en)
Inventor
Rajin Narain Niven
Patrick Mccook John
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44564137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2544663(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Berg Llc filed Critical Berg Llc
Publication of PT2544663T publication Critical patent/PT2544663T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT117541375T 2010-03-12 2011-03-11 Formulações intravenosas de coenzima q10 (coq10) e métodos de uso da mesma PT2544663T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31363210P 2010-03-12 2010-03-12
US38510710P 2010-09-21 2010-09-21

Publications (1)

Publication Number Publication Date
PT2544663T true PT2544663T (pt) 2018-04-05

Family

ID=44564137

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117541375T PT2544663T (pt) 2010-03-12 2011-03-11 Formulações intravenosas de coenzima q10 (coq10) e métodos de uso da mesma

Country Status (27)

Country Link
US (2) US11400058B2 (pt)
EP (2) EP3366280A1 (pt)
JP (4) JP5968231B2 (pt)
KR (2) KR102008658B1 (pt)
CN (2) CN102892412B (pt)
AU (4) AU2011224207B2 (pt)
BR (1) BR112012022916B1 (pt)
CA (2) CA2791693C (pt)
CL (1) CL2012002507A1 (pt)
CO (1) CO6620033A2 (pt)
CR (1) CR20120507A (pt)
CY (1) CY1120290T1 (pt)
DK (1) DK2544663T3 (pt)
EA (1) EA032941B1 (pt)
ES (1) ES2664793T3 (pt)
HK (1) HK1219055A1 (pt)
IL (1) IL221675B (pt)
MX (1) MX344078B (pt)
MY (1) MY163995A (pt)
NZ (3) NZ701451A (pt)
PE (1) PE20130045A1 (pt)
PH (1) PH12012501806B1 (pt)
PL (1) PL2544663T3 (pt)
PT (1) PT2544663T (pt)
SG (3) SG10202010355PA (pt)
TW (2) TWI602562B (pt)
WO (1) WO2011112900A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201101519A1 (ru) 2009-05-11 2012-10-30 БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи Способы диагностики метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
DK2544663T3 (en) * 2010-03-12 2018-04-16 Berg Llc INTRAVENOUS FORMULATIONS OF COENZYM Q10 (CoQ10) AND PROCEDURES FOR USING IT
CN103608323B (zh) 2011-04-04 2016-08-17 博格有限责任公司 治疗中枢神经系统肿瘤的方法
JP5932993B2 (ja) 2011-06-17 2016-06-08 バーグ エルエルシー 吸入可能な医薬組成物
KR102163948B1 (ko) * 2012-06-01 2020-10-12 버그 엘엘씨 조효소 q10을 이용한 고형 종양의 치료
NZ713868A (en) 2013-04-08 2021-12-24 Berg Llc Treatment of cancer using coenzyme q10 combination therapies
HUE050060T2 (hu) * 2013-09-04 2020-11-30 Berg Llc Eljárások rák kezelésére koenzim Q10 folyamatos infúziójával
EP3129002A4 (en) * 2014-04-09 2017-11-08 Nanoceutica Laboratories Pvt. Ltd Composition and method of producing nanoformulation of water insoluble bioactives in aqueous base
GB2544843B (en) * 2015-07-14 2022-08-03 Professional Compounding Centers Of America Pcca Poloxamer-based intralesional injections for the delivery of chemotherapeutic agents
US20170189350A1 (en) * 2015-11-16 2017-07-06 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
WO2018213502A1 (en) 2017-05-17 2018-11-22 Berg Llc Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa
CA3128398A1 (en) 2018-02-01 2019-08-08 The Royal Institution For The Advancement Of Learning / Mcgill University Formulations for improving the delivery of hydrophobic agents
EP3773520A4 (en) * 2018-04-09 2021-12-22 Orgenesis Inc. BIOXOMES AND REDOXOMES PARTICLES, PROCESS AND COMPOSITION
WO2020081601A1 (en) * 2018-10-15 2020-04-23 Berg Llc Methods of treating pancreatic cancer using coenzyme q10
IL268457B (en) 2019-08-04 2022-05-01 Omega 3 Galilee Ltd Oil- suspension of edible solids and methods of preparing the same
WO2021102356A1 (en) 2019-11-20 2021-05-27 Berg Llc Combination therapy of a coenzyme q10 compound and radiation therapy for treatment of glioma
JPWO2023120553A1 (pt) * 2021-12-24 2023-06-29

Family Cites Families (350)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525350A (en) * 1975-02-20 1985-06-25 The New England Institute, Inc. Methods of stimulating host defense system with coenzymes Q4 to Q.sub.1
JPS5612309A (en) 1979-07-11 1981-02-06 Kyowa Hakko Kogyo Co Ltd Oral drug containing ubidecarenone
JPS5618914A (en) 1979-07-25 1981-02-23 Eisai Co Ltd Ubidecarenone composition having good absorbability
JPS56109590A (en) 1980-02-05 1981-08-31 Zeria Shinyaku Kogyo Kk Production of clathrate compound of coenzyme q10
JPS588010A (ja) 1981-07-08 1983-01-18 Eisai Co Ltd ユビデカレノン含有リポソ−ム
IT1157269B (it) * 1982-03-19 1987-02-11 Seuref Ag Nuove formulazioni farmaceutiche contenenti il coenzima q10 adatte per la somministrazione topica
JPS58201711A (ja) * 1982-05-19 1983-11-24 Eisai Co Ltd ユビデカレノン含有リポソ−ム被覆体
JPS59148718A (ja) 1983-02-10 1984-08-25 Fujisawa Pharmaceut Co Ltd ユビデカレノン組成物
JPS59148735A (ja) 1983-02-14 1984-08-25 Fujisawa Pharmaceut Co Ltd ユビデカレノン組成物
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
JPS601124A (ja) 1983-06-16 1985-01-07 Eisai Co Ltd ユビデカレノン含有リポソ−ム被覆体
US5220042A (en) 1984-01-26 1993-06-15 Otsuka Pharmaceutical Co., Ltd. 1,4-benzoquinone derivatives and benzene derivatives, and process for preparing the same
JPS60199814A (ja) 1984-03-24 1985-10-09 Taisho Pharmaceut Co Ltd ユビデカレノン脂肪乳剤
GB8423436D0 (en) 1984-09-17 1984-10-24 Riker Laboratories Inc Preparation of liposomes
IT1191608B (it) 1985-02-01 1988-03-23 Zambon Spa Composizione farmaceutica e forme farmaceutiche che la contengono
US4824669A (en) 1985-04-11 1989-04-25 Board Of Regents, The University Of Texas System Formulations of coenzyme Q10 for intravenous use
US4895727A (en) * 1985-05-03 1990-01-23 Chemex Pharmaceuticals, Inc. Pharmaceutical vehicles for exhancing penetration and retention in the skin
US5192528A (en) 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
DE3524788A1 (de) 1985-07-11 1987-01-22 Lentia Gmbh Stabile, intravenoes applizierbare, waessrige fettemulsion und ein verfahren zu deren herstellung
JPH0665645B2 (ja) 1985-09-18 1994-08-24 日清製粉株式会社 自己乳化型軟カプセル薬液
JPS62123113A (ja) 1985-11-22 1987-06-04 Green Cross Corp:The ユビデカレノン含有脂肪乳剤
SE8603812D0 (sv) 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
IT1214540B (it) 1986-10-23 1990-01-18 Vincenzo Zappia Mario De Rosa Formulazioni idrosolubili di ubidecarenoni, procedimento per laloro preparazione e composizioni farmaceutiche che li compongono.
JPS63188623A (ja) 1987-01-31 1988-08-04 Taisho Pharmaceut Co Ltd 吸収改善ユビデカレノン製剤
JPS63313727A (ja) 1987-06-17 1988-12-21 Noriyoshi Saeki 外用治療剤
JP2512310B2 (ja) 1987-06-24 1996-07-03 エーザイ株式会社 被覆脂肪乳剤
US5651991A (en) * 1987-10-28 1997-07-29 Nippon Shinyaku Co. Ltd. Drug carriers
GB8811410D0 (en) * 1988-05-13 1988-06-15 Unilever Plc Treatment of skin disorders
US5015483A (en) * 1989-02-09 1991-05-14 Nabisco Brands, Inc. Liposome composition for the stabilization of oxidizable substances
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5962243A (en) * 1990-04-18 1999-10-05 Board Of Regents, The University Of Texas System Methods for the identification of farnesyltransferase inhibitors
ATE117665T1 (de) * 1990-11-14 1995-02-15 Oreal Amphiphile, nichtionische derivate des glycerins sowie die entsprechenden zwischenprodukte, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen.
US5298246A (en) 1991-01-09 1994-03-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Stable pharmaceutical composition and method for its production
SE502569C2 (sv) * 1991-05-31 1995-11-13 British Tech Group Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit
IT1250672B (it) 1991-07-11 1995-04-21 Idb Holding Spa Formulazioni orali di ubidecarenone in soluzione acquosa
US5378461A (en) * 1991-07-12 1995-01-03 Neigut; Stanley J. Composition for the topical treatment of skin damage
US6461593B1 (en) * 1992-02-19 2002-10-08 Biomedical And Clinical Research Therapy with coenzyme Q10 to reduce subgingival microorganisms in patients with periodontal disease
WO1993016704A1 (en) 1992-02-24 1993-09-02 East Carolina University Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereof
IT1256386B (it) * 1992-11-13 1995-12-04 Luigi Boltri Composizioni farmaceutiche comprendenti un farmaco,una sostanza polimerica reticolata,un olio ed un agente tensioattivo
US5602184A (en) * 1993-03-03 1997-02-11 The United States Of America As Represented By Department Of Health And Human Services Monoterpenes, sesquiterpenes and diterpenes as cancer therapy
US5885486A (en) 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
ATE166573T1 (de) * 1993-03-24 1998-06-15 Ciba Geigy Ag Verfahren zur herstellung einer liposomendispersion im hochdruckbereich
CA2120197A1 (en) * 1993-04-02 1994-10-03 Kenji Endo Stable aqueous dispersions containing liposomes
US5994314A (en) * 1993-04-07 1999-11-30 Inhale Therapeutic Systems, Inc. Compositions and methods for nucleic acid delivery to the lung
DE4327063A1 (de) * 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
DE4410238A1 (de) * 1994-03-25 1995-09-28 Beiersdorf Ag Hautpflegemittel
US20020049422A1 (en) * 1994-03-31 2002-04-25 Brewitt Barbara A. Homeopathic preparations
EP0707658B1 (en) * 1994-05-06 2002-08-07 Beckman Coulter, Inc. Liquid stable thiol activator
CA2207093A1 (en) 1994-12-06 1996-06-13 Ryan Pharmaceuticals, Inc. Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
US6005086A (en) * 1995-01-13 1999-12-21 The Salk Institute For Biological Studies Farnesoid activated receptor polypeptides, and nucleic acid encoding the same
US5539021A (en) 1995-06-05 1996-07-23 The Dow Chemical Company Process for preparing high internal phase ratio emulsions and latexes derived thereof
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
DE19537027A1 (de) * 1995-10-05 1997-04-10 Beiersdorf Ag Hautpflegemittel für alte Haut
EP0869773B1 (en) 1995-12-15 2004-03-24 National Research Council Of Canada Archaeosomes, archaeosomes containing coenzyme q 10, and other types of liposomes containing coenzyme q 10 as adjuvants and as delivery vehicles
US5944012A (en) * 1996-03-25 1999-08-31 Pera; Ivo E. Method for dispensing antioxidant vitamins by inhalation background of the invention
DE19615577A1 (de) * 1996-04-19 1997-10-23 Beiersdorf Ag Verwendung von Salicin als antiirritativer Wirkstoff in kosmetischen und topischen dermatologischen Zubereitungen
US5891465A (en) * 1996-05-14 1999-04-06 Biozone Laboratories, Inc. Delivery of biologically active material in a liposomal formulation for administration into the mouth
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
TW497974B (en) 1996-07-03 2002-08-11 Res Dev Foundation High dose liposomal aerosol formulations
DE19647352C2 (de) * 1996-11-15 2000-06-29 Aqua Nova Getraenketechnologie Nicht alkoholisches Getränk mit einem Gehalt an Q 10
GB9625895D0 (en) * 1996-12-13 1997-01-29 Riley Patrick A Novel compound useful as therapeutic agents and assay reagents
US20040228910A1 (en) 1997-02-11 2004-11-18 Mse Pharmazeutika Gmbh Transdermal, oral and intravenous formulations of 2, 3-dimethoxy-5-methyl-6-decaprenyl-1, 4-benzoquinone
ATE201988T1 (de) * 1997-02-11 2001-06-15 Mse Pharmazeutika Gmbh Transdermale, orale und intravenöse zubereitungen von 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4- benzochinon
EP1007018B1 (de) * 1997-02-12 2003-10-08 MSE Pharmazeutika GmbH Verwendung von 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzochinon inder behandlung von tinnitus
CA2281684C (en) * 1997-02-28 2006-08-29 The Regents Of The University Of California Inhibition of cell-cell binding by lipid assemblies
US6599513B2 (en) * 1997-05-27 2003-07-29 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6372234B1 (en) * 1997-05-27 2002-04-16 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US5900230A (en) * 1997-08-18 1999-05-04 Squigle, Inc. Dental products to treat and prevent periodontal disease
EP1009383A1 (en) * 1997-09-04 2000-06-21 Biozone Laboratories, Inc. Oral liposomal delivery system
US6090407A (en) * 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US7348025B2 (en) 1997-09-23 2008-03-25 Research Development Foundation Small particle liposome aerosols for delivery of anticancer drugs
KR20010031501A (ko) * 1997-10-31 2001-04-16 추후제출 5-알파 환원효소 활성을 조절하는 방법 및 조성물
US6696484B2 (en) * 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
WO1999026657A1 (en) * 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6372880B1 (en) * 1997-12-25 2002-04-16 Mitsui Chemicals, Inc. Copolymer and process for preparing the same
KR100657388B1 (ko) 1998-04-14 2006-12-13 교와 학꼬 고교 가부시키가이샤 미생물에 의한 이소프레노이드 화합물의 제조 방법
US6503523B2 (en) * 1998-05-07 2003-01-07 Gs Development A.B. Skin care agents containing combinations of active agents consisting of vitamin a derivatives and UBI- or plastoquinones
US6054261A (en) * 1998-05-20 2000-04-25 Q-Pharma, Inc. Coenzyme Q10 compositions for organ protection during perfusion
EP1089714B1 (en) 1998-06-19 2003-03-05 Skyepharma Canada Inc. Processes to generate particles of water-insoluble compounds of up to 2000 nm in size
DE19828081C2 (de) * 1998-06-24 2000-08-10 Cognis Deutschland Gmbh W/O-Emulsionsgrundlagen
US6623746B1 (en) * 1998-07-16 2003-09-23 Cognis Deutschland Gmbh & Co. Kg PIT emulsions, methods of softening paper using the same, and paper substrates treated therewith
US6048886A (en) * 1998-10-05 2000-04-11 Neigut; Stanley Compositions and delivery systems for the topical treatment of psoriasis and other conditions of the skin
IT1304406B1 (it) * 1998-10-21 2001-03-19 Danital Italia S R L Preparazione per la veicolazione di principi attivi basata su acidigrassi polinsaturi del gruppo omega 3.
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US6200550B1 (en) * 1998-12-11 2001-03-13 Q-Pharma, Inc. Oral care compositions comprising coenzyme Q10
CA2260397A1 (en) 1999-01-29 2000-07-29 Atlantis Marine Inc. Method of converting rendered triglyceride oil from marine sources into bland, stable food oil
US20040034107A1 (en) 1999-02-11 2004-02-19 Mse Pharmazeutika Gmbh Ubiquinone Qn for the treatment of pain
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
US20020048551A1 (en) 1999-04-06 2002-04-25 Keller Brian C. Delivery of biologically active material in a liposomal formulation for administration into the mouth
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6803193B1 (en) 1999-06-23 2004-10-12 The Penn State Research Foundation Methods to identify modulators of the mevalonate pathway in sterol synthesis
DE59912559D1 (de) 1999-07-02 2005-10-20 Cognis Ip Man Gmbh Mikrokapseln - III
US6334999B1 (en) * 1999-08-27 2002-01-01 Research Development Foundation Liposomal aerosols for delivery of chemotherapeutic retinoids to the lungs
US6479058B1 (en) * 1999-09-02 2002-11-12 Mccadden Michael E. Composition for the topical treatment of poison ivy and other forms of contact dermatitis
US6656928B1 (en) * 1999-09-02 2003-12-02 Mccadden Michael E. Composition for the topical treatment of rashes, dermatoses and lesions
US20030104080A1 (en) * 1999-09-07 2003-06-05 Singh Parashu Ram Topical urea composition
US6630160B1 (en) * 1999-09-07 2003-10-07 Genetic Services Management, Inc. Process to modulate disease risk with doses of a nutraceutical
US20030180352A1 (en) 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
DE19959546A1 (de) 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US7083780B2 (en) 1999-12-11 2006-08-01 Cognis Deutschland Gmbh & Co. Kg Cosmetic composition containing hydroxyethers
EP1239826A2 (de) * 1999-12-20 2002-09-18 Cognis France S.A. Kosmetische und/oder pharmazeutische zubereitungen
US8753675B1 (en) 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications
US6740338B1 (en) 2000-01-20 2004-05-25 Raj K. Chopra Reduced form of Cenzyme Q in high bioavailability stable oral dosage form
FR2804864B1 (fr) * 2000-02-11 2003-04-04 Serobiologiques Lab Sa Extraits de residus issus de la fabrication du vin et leur utilisation en cosmetique ou pharmacologie
US20020044913A1 (en) * 2000-02-11 2002-04-18 Hamilton Nathan D. Cosmetics to support skin metabolism
DE10007322A1 (de) * 2000-02-17 2001-08-23 Cognis Deutschland Gmbh Perlglanzmittel
DE50115609D1 (de) * 2000-02-17 2010-10-14 Basf Se Wässrige Dispersion wasserunlöslicher organischer UV-Filtersubstanzen
FR2805464B1 (fr) 2000-02-25 2003-02-14 Serobiologiques Lab Sa Preparations cosmetiques contenant des extraits de la plante mourera fluviatilis
DE10009996B4 (de) * 2000-03-02 2005-10-13 Cognis Ip Management Gmbh Feststoffgranulate mit monodisperser Korngrößenverteilung, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
RU2251405C2 (ru) 2000-03-27 2005-05-10 Шотт Глас Композиции для косметических препаратов, средств личной гигиены, компонентов очищающего действия, пищевых добавок, способы их получения и применения
US6447760B2 (en) * 2000-05-08 2002-09-10 Playtex Products, Inc. Sunless tanning compositions
US6468552B1 (en) * 2000-06-02 2002-10-22 Neutrogena Corporation Stabilized compositions containing oxygen-labile active agents
DE10031703A1 (de) 2000-06-29 2002-01-10 Beiersdorf Ag Verwendung von Calcium freisetzenden oder bindenden Substanzen zur gezielten Schächung oder Stärkung der Barrierefunktion der Haut
EP1170015A1 (de) 2000-07-06 2002-01-09 Laboratoires Serobiologiques(Societe Anonyme) Verwendung von Extrakten des Pilzes Grifola frondosa
DE10033022A1 (de) 2000-07-07 2002-01-17 Cognis Deutschland Gmbh Aerosole
DE10034619A1 (de) 2000-07-17 2002-01-31 Cognis Deutschland Gmbh Aniontensidfreie niedrigviskose Trübungsmittel
DE10036655A1 (de) * 2000-07-26 2002-02-07 Basf Ag Kosmetische oder dermatologische Zubereitungen zur Vermeidung von Hautschädigungen durch Peroxide
DE10036799A1 (de) 2000-07-28 2002-02-07 Beiersdorf Ag Neues Mittel zur Behandlung der Haare und der Kopfhaut
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US6441050B1 (en) * 2000-08-29 2002-08-27 Raj K. Chopra Palatable oral coenzyme Q liquid
FR2813195B1 (fr) 2000-08-29 2003-04-04 Serobiologiques Lab Sa Utilisation d'extraits de la plante cassia alata dans des produits de soin
DE10048260A1 (de) * 2000-09-29 2002-04-11 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Aminoguanidin und/oder dessen Derivaten und Strukturanaloga zur Hautaufhellung von Altersflecken und/oder zur Verhinderung der Hautbräunung, insbesondere der durch UV-Strahlung hervorgerufenen Hautbräunung
DE10053328A1 (de) 2000-10-27 2002-05-08 Cognis Deutschland Gmbh Kosmetische Zubereitungen
US6403116B1 (en) * 2000-11-03 2002-06-11 Triarco Inductries, Inc. Coenzyme Q10 formulation
US6756062B2 (en) 2000-11-03 2004-06-29 Board Of Regents University Of Texas System Preparation of drug particles using evaporation precipitation into aqueous solutions
US20070003536A1 (en) 2000-11-21 2007-01-04 Zimmerman Amy C Topical skin compositions, their preparation, and their use
DE10064219B9 (de) 2000-12-22 2009-02-12 Nasalis Pain Relief International Gmbh Neue Fentanyl und/oder dessen Derivate enthaltende pharmazeutische Zusammensetzung zur nasalen Anwendung
DE10064818A1 (de) * 2000-12-22 2002-06-27 Basf Ag Verwendung von Chroman-Derivaten in kosmetischen oder dermatologischen Zubreitungen
US6806069B2 (en) 2001-01-09 2004-10-19 Pharmachem Laboratories, Inc. Ubiquinone composition and methods related thereto
FR2819414A1 (fr) 2001-01-15 2002-07-19 Cognis France Sa Preparations cosmetiques et/ou pharmaceutiques comprenant des extraits de plantes dites a resurrection
NL1017205C2 (nl) 2001-01-26 2002-07-29 Adriaan Emanuel Hendricus Wiel Medicinale en cosmetische toepassing van hop en co-enzym Q10.
EP1357900A2 (en) 2001-01-30 2003-11-05 Board of Regents, The University of Texas System Process for production of nanoparticles and microparticles by spray freezing into liquid
ATE381923T1 (de) 2001-02-11 2008-01-15 Aquanova Ag Verfahren zur herstellung eines wirkstoffkonzentrats sowie wirkstoffkonzentrat
US6300377B1 (en) * 2001-02-22 2001-10-09 Raj K. Chopra Coenzyme Q products exhibiting high dissolution qualities
DE10113046A1 (de) 2001-03-15 2002-09-26 Beiersdorf Ag Selbstschäumende schaumförmige Zubereitungen mit organischen Hydrokolliden und partikulären hydrophobisierten und/oder ölabsorbierenden Festkörpersubstanzen
DE10113053A1 (de) 2001-03-15 2002-09-19 Beiersdorf Ag Selbstschäumende oder schaumförmige Zubereitungen mit anorganischen Gelbildnern und organischen Hydrololloiden
DE10113050A1 (de) 2001-03-15 2002-09-19 Beiersdorf Ag Selbstschäumende oder schaumförmige Zubereitungen organischen Hydrokolloiden
EP1243252B1 (fr) 2001-03-23 2006-05-24 L'oreal Composition pour le peau, contenant des fibres et des ubiquinones
US20030031688A1 (en) * 2001-04-02 2003-02-13 Dipak Ghosh Cosmetic composition with improved skin moisturizing properties
US6727234B2 (en) 2001-04-03 2004-04-27 University Of Iowa Research Foundation Isoprenoid analog compounds and methods of making and use thereof
DE10118269A1 (de) 2001-04-12 2002-10-17 Cognis Deutschland Gmbh Kosmetische Zubereitungen
US6686485B2 (en) * 2001-04-19 2004-02-03 Daniel David West Synthesis of coenzyme Q10, ubiquinone
US6582723B2 (en) * 2001-05-03 2003-06-24 Wayne F. Gorsek Cancer immune composition for prevention and treatment of individuals
JP3742602B2 (ja) 2001-05-09 2006-02-08 株式会社カネカ 還元型補酵素qの安定な溶液
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes
JP4603192B2 (ja) 2001-05-10 2010-12-22 株式会社カネカ 毛髪頭皮用組成物
DE10123771B4 (de) 2001-05-16 2019-01-10 Beiersdorf Ag Verwendung von Elektrolyten zur Stärkung der Barrierefunktion der Haut
AUPR510001A0 (en) 2001-05-18 2001-06-14 Jupitar Pty Ltd Formulation and method
EP1260212A1 (de) 2001-05-21 2002-11-27 Cognis France S.A. Kosmetische Mittel
US7091241B2 (en) 2001-06-01 2006-08-15 Summa Health System Nontoxic potentiation/sensitization of cancer therapy by supplementary treatment with combined vitamins C and K3
EP1262167A1 (de) 2001-06-01 2002-12-04 Cognis France S.A. Kosmetische Zubereitungen enthaltend ein Extrakt von keimenden Pflanzen
US6506915B1 (en) * 2001-06-14 2003-01-14 Daniel David West Synthesis of coenzyme Q10 ubiquinone
FR2826017B1 (fr) 2001-06-15 2004-06-11 Cognis France Sa Melanges de tensioactifs
SE0102380D0 (sv) 2001-07-02 2001-07-02 Macronova Ab Kräm för behandling av åldersförändringar i huden hos människa
DE10133198A1 (de) 2001-07-07 2003-01-23 Beiersdorf Ag Kreatin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
JP2003020495A (ja) 2001-07-10 2003-01-24 Cognis Japan Ltd 油脂組成物
DE10133305B4 (de) 2001-07-12 2004-06-03 Aquanova German Solubilisate Technologies (Agt) Gmbh Ubichinon Konzentrat
CH695085A5 (de) * 2001-07-13 2005-12-15 Mibelle Ag Cosmetics Formulierungen zur Pflege der Haut nach Laserbehandlungen und/oder chemischen Peelings und Verwendung der Formulierungen.
TWI235146B (en) 2001-07-16 2005-07-01 Kaneka Corp Method of stabilizing reduced coenzyme q10 and method of acidic crystallization
US7414720B2 (en) 2001-07-27 2008-08-19 Herbert Wachtel Measuring particle size distribution in pharmaceutical aerosols
WO2003009704A2 (en) 2001-07-27 2003-02-06 N.V. Nutricia Enteral compositions for the prevention and/or treatment of sepsis
US20050142665A1 (en) 2003-12-23 2005-06-30 Boehringer Ingelheim International Gmbh Laser diffraction method for particle size distribution measurements in pharmaceutical aerosols
US6699464B1 (en) 2001-07-30 2004-03-02 Stiefel Laboratories, Inc. Compositions for treatment of hyperpigmentation and methods for making and using such compositions
EP1281392A1 (de) 2001-08-02 2003-02-05 Cognis France S.A. Kosmetische und/oder pharmaceutische Zubereitungen enthaltend Pflanzenextrakte
DE10139580A1 (de) 2001-08-10 2003-02-20 Beiersdorf Ag Kosmetische und dermatologische Zubereitungen in Form von O/W-Emulsionen mit einem Gehalt an Sterinen und/oder C12-C40-Fettsäuren
EP1423096B1 (en) 2001-08-29 2006-08-16 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
DE10143964A1 (de) 2001-09-07 2003-03-27 Basf Ag Emulgatorarme oder emulgatorfreie Systeme vom Typ Öl-in-Wasser mit einem Gehalt an Stabilisatoren und einem aminosubstituierten Hydroxybenzophenon
DE10143963A1 (de) 2001-09-07 2003-03-27 Basf Ag Kosmetische und dermatologische Zubereitungen in Form von W/O-Emulsionen, enthaltend ein aminosubstituiertes Hydroxybenzophenon
DE10143962A1 (de) 2001-09-07 2003-03-27 Basf Ag Kosmetische und dermatologische Zubereitungen in Form von O/W-Emulsionen, enthaltend ein aminosubstituiertes Hydroxybenzophenon
US7425320B2 (en) 2001-09-18 2008-09-16 Ciba Specialty Chemicals Corp Use of guaiol for treating the skin
DE10150725A1 (de) 2001-10-13 2003-04-17 Cognis Deutschland Gmbh Aniontensidfreie niedrigviskose Trübungsmittel
US7560123B2 (en) 2004-08-12 2009-07-14 Everett Laboratories, Inc. Compositions and methods for nutrition supplementation
US20060039956A1 (en) 2001-10-26 2006-02-23 Hermann Hensen Impregnating solution for cosmetic cloths
US6753325B2 (en) 2001-11-06 2004-06-22 The Quigley Corporation Composition and method for prevention, reduction and treatment of radiation dermatitis
US20030105031A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Methods for the treatment of skin disorders
DE10155769A1 (de) 2001-11-14 2003-05-22 Cognis Deutschland Gmbh Kosmetische und/oder pharmazeutische Emulsionen
DE10160682A1 (de) 2001-12-11 2003-06-18 Cognis Deutschland Gmbh Emollients und kosmetische Zusammensetzungen
US6652891B2 (en) * 2001-12-12 2003-11-25 Herbasway Laboratories, Llc Co-enzyme Q10 dietary supplement
DE10162026A1 (de) 2001-12-18 2003-07-03 Cognis Deutschland Gmbh Hochkonzentriert fließfähige Perlglanzkonzentrate
DE10162351A1 (de) 2001-12-18 2003-07-03 Cognis Deutschland Gmbh Kosmetische und/oder pharmazeutische Emulsionen
ITRM20010755A1 (it) * 2001-12-20 2003-06-20 Simonelli Giuseppe Uso del chinone q10 per il trattamento delle malattie oculari.
US20030129253A1 (en) 2002-01-03 2003-07-10 Milley Christopher J. Stable aqueous suspension
US6696082B2 (en) 2002-01-08 2004-02-24 Mccully Kilmer S. Enhanced liposomal thioretinaco ozonide compositions and liposomal carrier
EP1469822A2 (de) 2002-01-18 2004-10-27 Basf Aktiengesellschaft Kosmetische oder dermatologische zubereitungen, enthaltend bor-organische verbindungen, zur vermei dung von hautschädigungen durch peroxide
TW200302056A (en) 2002-01-18 2003-08-01 Kaneka Corp Method for stabilizing reduced coenzyme Q10 and composition therefor
CN100473374C (zh) 2002-01-31 2009-04-01 西巴特殊化学品控股有限公司 微粉颜料混合物
KR100969059B1 (ko) 2002-02-12 2010-07-09 디에스엠 아이피 어셋츠 비.브이. 다이하이드로피리딘, 다이하이드로피란 및 일광차단 조성물
ATE392152T1 (de) 2002-02-14 2008-05-15 Dsm Ip Assets Bv Coenzym q10 formulierungen
EP1340486A1 (de) 2002-03-01 2003-09-03 Cognis France S.A. Verwendung von Zuckerestern
US20030167556A1 (en) 2002-03-05 2003-09-11 Consumers Choice Systems, Inc. Methods and devices for transdermal delivery of anti-aging compounds for treatment and prevention of facial or neck skin aging
WO2003075977A2 (en) * 2002-03-05 2003-09-18 Cleveland State University Agglomerated particles for aerosol drug delivery
WO2003075900A2 (de) 2002-03-09 2003-09-18 Mse Pharmazeutika Gmbh Verwendung von ubichinonen zur beeinflussung der histaminwirkung zur behandlung von bronchitis, asthma, allergischen krankheiten
DE10254315A1 (de) 2002-03-15 2003-10-02 Cognis Deutschland Gmbh Emollients und kosmetische Zubereitungen
TW200304372A (en) 2002-03-20 2003-10-01 Kanegafuchi Chemical Ind Compositions for diabetes
DE10212528A1 (de) 2002-03-21 2003-10-02 Cognis Deutschland Gmbh Ölphasen für kosmetische Mittel
US7811594B2 (en) 2002-03-28 2010-10-12 Beiersdorf Ag Crosslinked oil droplet-based cosmetic or pharmaceutical emulsions
DE10213957A1 (de) 2002-03-28 2003-10-09 Beiersdorf Ag Vernetzte kosmetische oder pharmazeutische phospholipidhaltige Gele und Emulsionen auf der Basis von ethylenoxidhaltigen oder propylenoxidhaltigen Emulgatoren
AU2003230750A1 (en) 2002-03-29 2003-10-13 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
DE10214983A1 (de) 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
DE10217474A1 (de) 2002-04-19 2003-11-06 Cognis Deutschland Gmbh Sonnenschutzemulsion mit Schaumspender
CA2483102C (en) 2002-04-25 2013-06-18 The Scripps Research Institute Treatment and prevention of pulmonary conditions
US20060193905A1 (en) 2002-05-14 2006-08-31 University Of Louisville Research Foundation, Inc. Direct cellular energy delivery system
US7939098B2 (en) * 2002-05-23 2011-05-10 Femina Pharma Incorporated Compositions and method for transmucosal drug delivery and cryoprotection
DE10223486A1 (de) 2002-05-27 2003-12-11 Beiersdorf Ag Kosmetische und/oder dermatologische Zubereitung mit 2,3-Dibenzylbutyrolactonen
EP1371355B1 (en) 2002-06-03 2006-08-02 Ciba SC Holding AG UV-protection formulations
EP1567180A4 (en) 2002-06-04 2010-03-10 Avicena Group Inc METHODS OF TREATING COGNITIVE DYSFUNCTIONS BY MODULATING BRAIN ENERGY METABOLISM
DE10226018A1 (de) 2002-06-12 2003-12-24 Cognis Deutschland Gmbh Zubereitungen mit konjugiertem Linolalkohol
US7147841B2 (en) 2002-06-17 2006-12-12 Ciba Specialty Chemicals Corporation Formulation of UV absorbers by incorporation in solid lipid nanoparticles
AU2003246592A1 (en) 2002-06-26 2004-01-19 Europroteome Ag Tumour marker and the use thereof for the diagnosis and treatment of tumour diseases
WO2004010958A2 (en) 2002-07-31 2004-02-05 Shaklee Corporation A method for maximizing scalp health and inducing enhanced visual and tactile hair quality
US6953786B2 (en) 2002-10-01 2005-10-11 The Regents Of The University Of California Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof
KR100484525B1 (ko) 2002-10-15 2005-04-20 씨제이 주식회사 이소티아졸 유도체, 그 제조방법 및 약제학적 조성물
US7241456B2 (en) 2002-10-25 2007-07-10 Australian Importers Ltd. Formulations for topical delivery of bioactive substances and methods for their use
EP1421929A3 (de) 2002-11-21 2004-11-24 Cognis Deutschland GmbH & Co. KG Emollients und kosmetische Zubereitungen
DE10255195A1 (de) 2002-11-27 2004-06-09 Lipoid Gmbh Micellare wasserlösliche Konzentrate
DE10256881A1 (de) 2002-12-05 2004-06-24 Beiersdorf Ag Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten
US20040110848A1 (en) 2002-12-10 2004-06-10 Peffley Dennis M Method and kit for treating cancer
CA2513006A1 (en) 2003-01-15 2004-08-05 Dow Global Technologies Inc. Drug particles obtained by freezing onto a cold surface
US8187575B2 (en) 2003-01-20 2012-05-29 BASF SE Ludwigshafen Triazine derivatives as UV absorbers
US20060140970A1 (en) 2003-01-23 2006-06-29 Adam Telerman Proteic binding partners of TCTP and methods of modulating tumor reversion or cell apoptosis
US20060073106A1 (en) 2003-02-03 2006-04-06 Dsm Ip Assets B.V. Novel stabilized cinnamic ester sunscreen compositions
US7258876B2 (en) 2003-02-05 2007-08-21 Craig Bozzacco Topical composition for treating infectious conditions of skin and mucosa
CN1208052C (zh) * 2003-03-20 2005-06-29 上海家化联合股份有限公司 一种辅酶q10前体脂质体及其制备方法
KR101187002B1 (ko) 2003-03-24 2012-09-28 시바 홀딩 인코포레이티드 대칭 트리아진 유도체
US7438903B2 (en) 2003-06-06 2008-10-21 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
US20110318405A1 (en) 2003-06-25 2011-12-29 Charles Erwin Chemical Combination and Method for Increasing Delivery of Coenzyme Q10
US20060035981A1 (en) 2003-08-02 2006-02-16 Mazzio Elizabeth A Inhibition of anaerobic glucose metabolism and corresponding composition as a natural non-toxic approach to cancer treatment
US20080069779A1 (en) 2003-08-04 2008-03-20 Foamix Ltd. Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof
US20050036976A1 (en) 2003-08-12 2005-02-17 Joel Rubin Topical skin care composition
WO2005020940A1 (de) 2003-08-27 2005-03-10 Beiersdorf Ag Kapsel deren kapselhülle bei topischer anwendung nicht mehr gesondert warhnembar ist
CH715855B1 (de) * 2003-08-28 2020-08-14 Mibelle Ag Zubereitung bestehend aus mindestens zwei Nanoemulsionen.
US8124072B2 (en) 2003-09-29 2012-02-28 Soft Gel Technologies, Inc. Solubilized CoQ-10
US7169385B2 (en) 2003-09-29 2007-01-30 Ronald G. Udell Solubilized CoQ-10 and carnitine
US8105583B2 (en) 2003-09-29 2012-01-31 Soft Gel Technologies, Inc. Solubilized CoQ-10
BRPI0414858A (pt) 2003-10-02 2006-11-21 Sembiosys Genetics Inc métodos para preparação de corpos de óleo compreendendo ingredientes ativos
DE10347218A1 (de) 2003-10-10 2005-05-12 Cognis Deutschland Gmbh Sonnenschutzmittel
DE10347940A1 (de) 2003-10-15 2005-05-19 Cognis Deutschland Gmbh & Co. Kg Selbstemulgierende Zubereitungen
JP4732898B2 (ja) 2003-10-31 2011-07-27 株式会社カネカ 還元型補酵素q含有組成物
AU2004290493B2 (en) 2003-11-05 2009-09-24 Dsm Ip Assets B.V. Light protecting composition with reduced total amount of UV filter containing a polysiloxane-based UV filter
US20050100537A1 (en) 2003-11-10 2005-05-12 Evans Gregory S. Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals
TW200524541A (en) 2003-11-17 2005-08-01 Cargill Inc Lecithin-containing granular compositions and methods of their preparation
DE20320413U1 (de) 2003-11-17 2004-08-26 Beiersdorf Ag Kosmetikum mit empfindlichen Inhaltsstoffen
ES2235642B2 (es) 2003-12-18 2006-03-01 Gat Formulation Gmbh Proceso de multi-microencapsulacion continuo para la mejora de la estabilidad y almacenamiento de ingredientes biologicamente activos.
CA3031283A1 (en) * 2004-01-22 2005-08-04 University Of Miami Topical co-enzyme q10 formulations and methods of use
US20050226947A1 (en) 2004-02-04 2005-10-13 Dale Kern Agents for sequestering serum aging factors and uses therefore
NZ549159A (en) 2004-02-19 2011-01-28 Chemaphor Inc Topical formulations for the treatment of skin conditions
US7780873B2 (en) 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
DE102004014615A1 (de) 2004-03-23 2005-10-13 Beiersdorf Ag Taurinhaltige Zubereitungen zur Verbesserung der Hautbarriere
DE102004020627A1 (de) 2004-03-23 2005-10-13 Beiersdorf Ag Kosmetische und dermatologische Lichtschutzformulierungen
US7182938B2 (en) 2004-04-06 2007-02-27 Basf Aktiengesellschaft Cosmetic formulations comprising ZnO nanoparticles
US20050226858A1 (en) 2004-04-09 2005-10-13 Kaneka Corporation Compositions containing reduced coenzyme Q10 and carotenoid
US7723569B2 (en) 2004-04-30 2010-05-25 National Institute Of Agrobiological Sciences Method for producing ubiquinone-10 in plant
US20070202090A1 (en) 2004-05-18 2007-08-30 Mirko Prosek Water Soluble Form Of Coenzyme Q10 In The Form Of An Inclusion Complex With Beta-Cyclodextrin, Process Of Preparing, And Use Thereof
WO2005112957A1 (en) 2004-05-21 2005-12-01 Transave, Inc. Treatment of lung diseases and pre-lung disease conditions
NZ551366A (en) 2004-05-24 2009-01-31 Basf Ag Keratin-binding polypeptides
CA2578709C (en) 2004-06-17 2010-06-15 Virun, Inc. Compositions comprising a mucoadhesive protein and an active principle for mucosal delivery of said agents
WO2005123101A1 (en) 2004-06-18 2005-12-29 Symrise Gmbh & Co. Kg Blackberry extract
AU2005265155A1 (en) 2004-06-21 2006-01-26 Hutchison Medipharma Enterprises Limited Cancer chemotherapy
ES2380940T3 (es) 2004-06-28 2012-05-21 Dsm Ip Assets B.V. Composiciones cosméticas que contienen hidrolizados de proteína
US7794694B2 (en) 2004-07-01 2010-09-14 E-L Management Corp. Cosmetic compositions and methods containing a tanning agent and liposome encapsulated ursolic acid
JP2006070016A (ja) 2004-08-02 2006-03-16 Kaneka Corp 還元型補酵素qを含有する美白用組成物
US20060051462A1 (en) 2004-09-03 2006-03-09 Wang Jimmy X Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients
US7288263B2 (en) 2004-09-13 2007-10-30 Evera Laboratories, Llc Compositions and methods for treatment of skin discoloration
DE102004046235A1 (de) 2004-09-22 2006-03-30 Altana Pharma Ag Arzneimittelzubereitung
EP1809272A4 (en) 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS
BRPI0517930A (pt) 2004-11-02 2008-10-21 Dsm Ip Assets Bv aditivo para preparações de protetor solar contra uv
GB0424891D0 (en) 2004-11-11 2004-12-15 Boots Co Plc Topical compositions
CN101119710B (zh) 2004-11-16 2013-03-27 生物利用股份有限公司 用于营养用途的高浓度自微乳化辅酶q10制剂
US20060127384A1 (en) 2004-12-09 2006-06-15 Sergio Capaccioli Coenzyme Q10 as antiapoptotic agent
US20060154993A1 (en) 2004-12-17 2006-07-13 Littarru Gian P Method for treating and preventing male infertility
NO20045674D0 (no) 2004-12-28 2004-12-28 Uni I Oslo Thin films prepared with gas phase deposition technique
US20060286046A1 (en) 2005-01-05 2006-12-21 Haber C Andrew Skin care compositions
CN102008729A (zh) 2005-01-07 2011-04-13 日本乐敦制药株式会社 外用组合物
US20080207560A1 (en) 2005-01-07 2008-08-28 Ayako Harada Composition For External Use
US20060188492A1 (en) 2005-01-13 2006-08-24 Chronorx Llc, An Alaska Limited Liability Company Topical management of ocular and periocular conditions
DE102005007980A1 (de) 2005-02-22 2006-02-23 Clariant Gmbh Kosmetische, pharmazeutische oder dermatologische Zubereitungen enthaltend Copolymerwachse
WO2007040591A2 (en) 2005-03-01 2007-04-12 Jarrow Formulas, Inc. A ubiquinone composition and a container for its convenient transport and storage
EP1871389A2 (en) 2005-04-01 2008-01-02 Zymes, LLC Skin enrichment using coq10 as the delivery system
EP1712220A1 (en) 2005-04-15 2006-10-18 PARI GmbH Spezialisten für effektive Inhalation Pharmaceutical aerosol composition
US20080312128A1 (en) 2005-04-29 2008-12-18 Edward Chaum Cellular Biomarker Antioxidant Assay and Uses Thereof
US20060280691A1 (en) 2005-06-13 2006-12-14 University Of Alberta Spray freeze dried liposomal ciprofloxacin powder aerosol drug delivery
US9168216B2 (en) 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
ITPD20050224A1 (it) 2005-07-19 2007-01-20 Actimex Srl Composizioni contenenti micronutrienti aventi in particolare attivita' antiossidante e loro impiego
US20100150894A1 (en) 2005-07-28 2010-06-17 Kaneka Corporation Composition for prevention of cancer
US20070053985A1 (en) 2005-08-24 2007-03-08 Kaneka Corporation Coenzyme Q10-containing fine particle with excellent dispersibility
US20070071779A1 (en) 2005-09-26 2007-03-29 Leggit Ingenuity, Llc Compositions for delivering lipophilic agents to the intestinal mucosa and method of making thereof
US20070092469A1 (en) 2005-10-26 2007-04-26 Eric Jacobs Topically applied Glucosamine Sulfate and all its related, precursor, and derivative compounds significantly increases the skin's natural produciton of hyaluronic acid for the rejuvenation of healthier younger-looking skin; while PhosphatidylCholine is required to replace its deficiency caused by topical Dimethylaminoethanol (DMAE)
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
US9265792B2 (en) 2005-11-16 2016-02-23 Patricia A. Riley Integument cell regeneration formulation
EP1957109A2 (en) 2005-12-02 2008-08-20 Sirtris Pharmaceuticals, Inc. Modulators of cdc2-like kinases (clks) and methods of use thereof
KR20080073288A (ko) 2005-12-09 2008-08-08 드러그테크 코포레이션 정맥내 필수 지방산 에멀젼
US20070172436A1 (en) 2006-01-23 2007-07-26 Jerry Zhang Nonaqueous ascorbic acid compositions and methods for preparing same
US20070184076A1 (en) 2006-02-07 2007-08-09 Unger Evan C Liquid-filled nanodroplets for anti-cancer therapy
CA2642096A1 (en) 2006-02-09 2008-02-28 Ocean Nutrition Canada Ltd. Coenzyme q10 production from marine bacteria
US20070184041A1 (en) 2006-02-09 2007-08-09 Burja Adam M Methods and compositions related to production of coenzyme q10
GB0603975D0 (en) 2006-03-01 2006-04-05 Etren Methods and agents for reducing oxidative stress
DK1993515T3 (da) * 2006-03-10 2009-12-07 Laboswiss Ag Fremgangsmåde til solubilisering, dispergering og stabilisering af stoffer, produkter, der er fremstillet efter fremgangsmåden og anvendelsen af samme
US7335384B2 (en) 2006-03-17 2008-02-26 4K Nutripharma International Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
TW200812567A (en) 2006-03-29 2008-03-16 Kaneka Corp Agent for improving nervous system cell functions
WO2007126086A1 (ja) 2006-04-28 2007-11-08 Kaneka Corporation 還元型補酵素q10の精製方法
US8021659B2 (en) 2006-04-28 2011-09-20 Naidu Lp Coenzyme Q10, lactoferrin and angiogenin compositions and uses thereof
US7829080B2 (en) 2006-04-28 2010-11-09 Kaneka Corporation Stabilization method of reduced coenzyme Q10
EP3173068B1 (en) 2006-05-02 2020-09-09 University of Miami Topical co-enzyme q10 formulations and treatment of wounds
US20080020022A1 (en) 2006-06-05 2008-01-24 Udell Ronald G Chewable co-enzyme q-10 capsule
US20080254017A1 (en) 2006-06-19 2008-10-16 Bodybio, Inc. Methods and compositions for treating symptomes of diseases related to imbalance of essential fatty acids
US20080008694A1 (en) 2006-07-05 2008-01-10 Elgebaly Salwa A Methods to prevent and treat diseases
RU2315593C1 (ru) 2006-08-02 2008-01-27 Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" Липосомальная композиция антиоксидантов для ингаляций при заболеваниях легких и верхних дыхательных путей
US8894993B2 (en) 2006-08-04 2014-11-25 Natreon Inc. Mitochondria-targeted antioxidants
EP1897530A1 (en) 2006-09-08 2008-03-12 DSMIP Assets B.V. Skin care composition
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US9114077B2 (en) 2006-11-17 2015-08-25 Abbvie Deutschland Gmbh & Co Kg Nanocrystals for use in topical cosmetic formulations and method of production thereof
JPWO2008062559A1 (ja) 2006-11-22 2010-03-04 旭化成ファーマ株式会社 栄養補助食品、抗疲労作用剤又は持久力増強剤、機能性食品又は化粧料
EP1927373B1 (en) 2006-11-30 2012-08-22 PARI Pharma GmbH Inhalation nebulizer
US20080138326A1 (en) 2006-12-06 2008-06-12 Kaneka Corporation Method for cancer treatment, carcinogenesis suppression or mitigation of adverse reactions of anticancer agents
CA2675745A1 (en) 2007-01-18 2008-07-24 Mark A. Pinsky Materials and methods for delivering antioxidants into the skin
CA2680825C (en) 2007-03-22 2013-10-29 Cytotech Labs, Llc Topical formulations having enhanced bioavailability
KR100849537B1 (ko) * 2007-07-04 2008-07-31 유효경 코엔자임 큐텐의 나노에멀젼 조성물
CN101091890A (zh) * 2007-07-26 2007-12-26 沈阳药科大学 一种复合型乳化剂及用其制备的乳剂及其制备方法
US9254268B2 (en) 2007-09-25 2016-02-09 Solubest Ltd. Compositions comprising lipophilic active compounds and method for their preparation
US8815567B2 (en) 2007-11-30 2014-08-26 E I Du Pont De Nemours And Company Coenzyme Q10 production in a recombinant oleaginous yeast
US20110142914A1 (en) 2007-12-06 2011-06-16 Cytotech Labs, Llc Inhalable compositions having enhanced bioavailability
US8272253B2 (en) 2008-01-22 2012-09-25 Ct Associates, Inc. Particle concentration measurement technology
KR101003204B1 (ko) 2008-02-14 2010-12-21 메콕스큐어메드 주식회사 약물 전달용 고형 지질 나노입자, 그 제조방법, 및 그나노입자를 포함하는 주사제
EP2273977A2 (en) 2008-04-08 2011-01-19 Zymes, LLC Dried formulations
US20110136231A1 (en) * 2008-04-11 2011-06-09 Cytotech Labs, Llc Methods and use of inducing apoptosis in cancer cells
WO2010008475A2 (en) 2008-06-23 2010-01-21 Virun, Inc. Compositions containing nono-polar compounds
US20100099775A1 (en) 2008-10-17 2010-04-22 Alpharx Inc. Method for ameliorating of post-anesthetic recovery
US20100129431A1 (en) 2008-11-24 2010-05-27 Alpharx Inc. Idebenone composition for the treatment of neurological disorders
US20100215725A1 (en) 2009-02-20 2010-08-26 Joseph Schwarz Pharmaceutical composition containing idebenone for the treatment of liver disorders
KR101066197B1 (ko) 2009-04-06 2011-09-20 한국생명공학연구원 코엔자임 q10 나노입자, 그 제조방법 및 상기 나노입자를 포함하는 조성물
EA201101519A1 (ru) 2009-05-11 2012-10-30 БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи Способы диагностики метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
US8408429B2 (en) * 2009-11-11 2013-04-02 The Clorox Company Bottle with integral dip tube
JP5951508B2 (ja) 2010-02-11 2016-07-13 アブリンクス エン.ヴェー. エアロゾルの調製のための方法及び組成物
DK2544663T3 (en) 2010-03-12 2018-04-16 Berg Llc INTRAVENOUS FORMULATIONS OF COENZYM Q10 (CoQ10) AND PROCEDURES FOR USING IT
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
US10869843B2 (en) 2010-11-23 2020-12-22 Chemi Nutra Method for increasing muscle mass and strength
US20120141446A1 (en) 2010-12-02 2012-06-07 Bhiku Patel Oral Nutritional Supplement Delivery System
TWI425914B (zh) 2011-03-21 2014-02-11 Food Industry Res & Dev Inst 含高濃度奈米/次微米疏水性機能化合物之水相分散液之製備方法
MY159478A (en) 2011-05-23 2017-01-13 Malaysian Palm Oil Board A process for producing nano-capsules and nano-beadlets containing phytonutrients derived from palm oil
JP5932993B2 (ja) 2011-06-17 2016-06-08 バーグ エルエルシー 吸入可能な医薬組成物
CN104254323A (zh) 2012-04-13 2014-12-31 旗帜药物胶囊公司 含有片剂和液体或半固体填充剂的软弹性胶囊及其制备方法
WO2013175266A1 (en) 2012-05-21 2013-11-28 Chemi Nutra Inc. Method for increasing muscle mass and strength
US9770421B2 (en) 2013-03-15 2017-09-26 Indanio Bioscience Inc. Uses for idebenone and related benzoquinones in metabolic disorders and other PPAR α/γ related diseases and conditions
KR20150062802A (ko) 2013-11-29 2015-06-08 삼성전자주식회사 소수성 활성 성분을 포함하는 내부 리포좀을 포함하는 이중막 리포좀, 및 그의 용도
JP6605508B2 (ja) 2014-02-27 2019-11-13 ビー‐オーガニック フィルムス コーポレイション 一重らせんv構造を有する官能化デンプン中に含まれる生物活性剤
CA2945323A1 (en) 2014-04-08 2015-10-15 University Of Massachusetts Food matrices and methods of making and using

Also Published As

Publication number Publication date
CN102892412B (zh) 2015-09-30
EP3366280A1 (en) 2018-08-29
CO6620033A2 (es) 2013-02-15
JP5968231B2 (ja) 2016-08-10
AU2020203490A1 (en) 2020-06-18
TWI602562B (zh) 2017-10-21
CL2012002507A1 (es) 2012-12-21
JP2021050221A (ja) 2021-04-01
JP2013522233A (ja) 2013-06-13
SG10202010355PA (en) 2020-11-27
DK2544663T3 (en) 2018-04-16
CA2791693A1 (en) 2011-09-15
KR101907411B1 (ko) 2018-10-12
PE20130045A1 (es) 2013-01-28
PH12012501806B1 (en) 2018-10-26
NZ602057A (en) 2015-06-26
IL221675B (en) 2018-06-28
MY163995A (en) 2017-11-15
EP2544663A4 (en) 2013-10-30
NZ720022A (en) 2018-07-27
JP2019059734A (ja) 2019-04-18
SG183508A1 (en) 2012-10-30
JP6431003B2 (ja) 2018-11-28
AU2016200991B2 (en) 2017-12-21
JP2016199573A (ja) 2016-12-01
CN102892412A (zh) 2013-01-23
US11400058B2 (en) 2022-08-02
EA201270735A1 (ru) 2013-02-28
AU2018202010B2 (en) 2020-02-27
BR112012022916A2 (pt) 2016-08-09
TWI610671B (zh) 2018-01-11
AU2016200991A1 (en) 2016-03-24
PH12012501806A1 (en) 2012-12-10
KR20180112876A (ko) 2018-10-12
PL2544663T3 (pl) 2018-09-28
CN105168135A (zh) 2015-12-23
MX344078B (es) 2016-12-05
US20230165809A1 (en) 2023-06-01
AU2011224207A1 (en) 2012-09-13
JP6861682B2 (ja) 2021-04-21
WO2011112900A3 (en) 2012-01-12
MX2012010513A (es) 2013-01-18
CR20120507A (es) 2012-12-04
ES2664793T3 (es) 2018-04-23
EP2544663A2 (en) 2013-01-16
CY1120290T1 (el) 2019-07-10
KR102008658B1 (ko) 2019-08-08
US20110229554A1 (en) 2011-09-22
NZ701451A (en) 2016-09-30
KR20140021467A (ko) 2014-02-20
TW201703761A (zh) 2017-02-01
TW201141467A (en) 2011-12-01
EP2544663B1 (en) 2018-01-03
AU2011224207B2 (en) 2015-11-19
HK1219055A1 (zh) 2017-03-24
CA2791693C (en) 2018-11-27
BR112012022916B1 (pt) 2021-11-09
WO2011112900A2 (en) 2011-09-15
AU2018202010A1 (en) 2018-04-12
CA3022054A1 (en) 2011-09-15
EA032941B1 (ru) 2019-08-30
SG10201501872XA (en) 2015-05-28

Similar Documents

Publication Publication Date Title
HK1219055A1 (zh) 輔酶 的靜脈內製劑及其使用方法
HK1202244A1 (en) Prebiotic formulations and methods of use
ZA201300193B (en) Formulations of rifaximin and uses thereof
EP2563372A4 (en) PREBIOTIC FORMULATIONS AND METHODS OF USE
EP2654726A4 (en) SOLID DISPERSION FORMULATIONS AND METHODS OF USE
EP2536283B8 (en) Phenyl-heteroaryl derivatives and methods of use thereof
IL222227A0 (en) Pyrazol - 4 - heterocyclyl-carboxamide compounds and methods of use
EP3626253B8 (en) Stable formulations of linaclotide
EP2613802A4 (en) ENVIRONMENTAL CLOSTRIDAL BACTERIOTHERAPY AND ASSOCIATED FORMULATIONS AND METHODS OF MAKING AND USING SAME
ZA201300930B (en) St-246 liquid formulations and methods
IL221043A0 (en) Modified release formulation and methods of use
EP2547340A4 (en) OPHTHALMIC FORMULATIONS OF CETIRICINE AND METHOD FOR THEIR USE
PL2525782T3 (pl) Preparaty nanonośników i sposoby ich wytwarzania
EP2636666A4 (en) TRANS-2 DECENTRIC ACID DERIVATIVES AND MEDICAMENTS CONTAINING THEREOF
IL224192A (en) Compositions of Vitamin 14 – Epi Analogs d
IL223707A (en) A n-hydroxypermamide product and a drug containing it
EP2533762A4 (en) RETINOL FORMULATIONS AND METHOD FOR THEIR USE
GB2480998B (en) Expandable armrest of wheel chair
EP2525660A4 (en) FORMULATION WITH MODIFIED RELEASE AND USE METHOD
TWM385289U (en) Structure of chair footrest
TWM389178U (en) Improved structure of caster