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PL2356227T3 - Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych - Google Patents

Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych

Info

Publication number
PL2356227T3
PL2356227T3 PL09826863T PL09826863T PL2356227T3 PL 2356227 T3 PL2356227 T3 PL 2356227T3 PL 09826863 T PL09826863 T PL 09826863T PL 09826863 T PL09826863 T PL 09826863T PL 2356227 T3 PL2356227 T3 PL 2356227T3
Authority
PL
Poland
Prior art keywords
capsulation
cells
pancreas
originating
pluripotential stem
Prior art date
Application number
PL09826863T
Other languages
English (en)
Inventor
Laura Martinson
Chad Green
Evert Kroon
Alan Agulnick
Olivia Kelly
Emmanuel E. Baetge
Original Assignee
Viacyte, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viacyte, Inc. filed Critical Viacyte, Inc.
Publication of PL2356227T3 publication Critical patent/PL2356227T3/pl

Links

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/12Chemical aspects of preservation
    • A01N1/122Preservation or perfusion media
    • A01N1/125Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/022Artificial gland structures using bioreactors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/39Pancreas; Islets of Langerhans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
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    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/0678Stem cells; Progenitor cells; Precursor cells
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2035/126Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62Encapsulated active agents, e.g. emulsified droplets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/04General characteristics of the apparatus implanted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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    • C12N2501/38Hormones with nuclear receptors
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Proteomics, Peptides & Aminoacids (AREA)
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PL09826863T 2008-11-14 2009-11-13 Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych PL2356227T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11485708P 2008-11-14 2008-11-14
US12108608P 2008-12-09 2008-12-09
EP09826863.4A EP2356227B1 (en) 2008-11-14 2009-11-13 Encapsulation of pancreatic cells derived from human pluripotent stem cells
PCT/US2009/064459 WO2010057039A2 (en) 2008-11-14 2009-11-13 Encapsulation of pancreatic cells derived from human pluripotent stem cells

Publications (1)

Publication Number Publication Date
PL2356227T3 true PL2356227T3 (pl) 2018-07-31

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PL09826863T PL2356227T3 (pl) 2008-11-14 2009-11-13 Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych

Country Status (9)

Country Link
US (9) US8278106B2 (pl)
EP (3) EP2356227B1 (pl)
JP (6) JP2012508584A (pl)
CN (2) CN105349517B (pl)
AU (1) AU2009313870B2 (pl)
CA (2) CA2743641C (pl)
ES (2) ES2667493T3 (pl)
PL (1) PL2356227T3 (pl)
WO (1) WO2010057039A2 (pl)

Families Citing this family (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432104B2 (en) * 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
CN101952415B (zh) 2007-07-31 2017-06-27 生命扫描有限公司 人胚胎干细胞的分化
CA2706560C (en) 2007-11-27 2017-02-28 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
KR101731474B1 (ko) 2008-02-21 2017-05-11 얀센 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
GB2460842B (en) * 2008-06-10 2011-02-16 Cryogenetics As Packaging for biological material
JP5734183B2 (ja) 2008-06-30 2015-06-17 ヤンセン バイオテツク,インコーポレーテツド 多能性幹細胞の分化
BRPI0919885A2 (pt) 2008-10-31 2015-08-11 Centocor Ortho Biotech Inc Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática
KR102025158B1 (ko) 2008-10-31 2019-09-25 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 계통으로의 분화
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト,インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
KR101687344B1 (ko) 2008-11-20 2016-12-16 얀센 바이오테크 인코포레이티드 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물
WO2010059775A1 (en) 2008-11-20 2010-05-27 Centocor Ortho Biotech Inc. Pluripotent stem cell culture on micro-carriers
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
WO2014124172A1 (en) * 2013-02-06 2014-08-14 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
BR112012001480A2 (pt) 2009-07-20 2015-09-01 Janssen Biotech Inc Diferenciação de células-tronco embriônicas humanas
DK3290061T3 (da) 2009-08-28 2020-07-13 Sernova Corp Fremgangsmåder og anordninger til cellulær transplantation
WO2011057249A2 (en) 2009-11-09 2011-05-12 The Brigham And Women's Hospital, Inc. Treatment of heart disease
BR112012017761A2 (pt) 2009-12-23 2015-09-15 Centocor Ortho Biotech Inc diferenciação das células-tronco embrionárias humanas
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
CN107189979B (zh) 2010-03-01 2021-05-04 詹森生物科技公司 纯化衍生自多能干细胞的细胞的方法
SG185511A1 (en) 2010-05-12 2012-12-28 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
SG187655A1 (en) 2010-08-09 2013-03-28 Takeda Pharmaceutical Method of producing pancreatic hormone-producing cells
KR20180032674A (ko) 2010-08-12 2018-03-30 얀센 바이오테크 인코포레이티드 췌장 내분비 전구 세포를 이용한 당뇨병의 치료
AU2015213422A1 (en) * 2010-08-12 2015-09-10 Janssen Biotech, Inc. Treatment of diabetes with pancreatic endocrine precursor cells
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
EP2611907B1 (en) 2010-08-31 2016-05-04 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
WO2012030538A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN103154239B (zh) 2010-08-31 2018-05-15 詹森生物科技公司 人胚胎干细胞的分化
WO2012041320A1 (en) 2010-09-27 2012-04-05 Nsgene A/S Implantable cell device with supportive and radial diffusive scaffolding
MX2010013135A (es) * 2010-11-30 2012-05-31 Val De Bio S De R L De C V Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico.
US9433557B2 (en) 2011-02-21 2016-09-06 Viacyte, Inc. Loading system for an encapsulation device
ES2902650T3 (es) 2011-06-21 2022-03-29 Novo Nordisk As Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes
CN102550542B (zh) * 2011-08-09 2014-06-25 臻景生物技术(上海)有限公司 用于脂肪干细胞的无血清冻存液及脂肪干细胞库的建立
US20140242038A1 (en) * 2011-10-11 2014-08-28 The Trustees Of Columbia University In The City Of New York Method for generating beta cells
USD726307S1 (en) * 2011-12-12 2015-04-07 Viacyte Inc. Cell encapsulation device
USD726306S1 (en) * 2011-12-12 2015-04-07 Viacyte, Inc. Cell encapsulation device
USD728095S1 (en) * 2011-12-12 2015-04-28 Viacyte, Inc. Cell encapsulation device
JP6441080B2 (ja) 2011-12-22 2018-12-19 ヤンセン バイオテツク,インコーポレーテツド 単一ホルモンのインスリン陽性細胞へのヒト胚性幹細胞の分化
EP2823037A4 (en) 2012-03-07 2015-09-16 Janssen Biotech Inc DEFINED MEDIA FOR THE EXPANSION AND CARE OF PLURIPOTENTAL STEM CELLS
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US10696554B2 (en) 2015-08-06 2020-06-30 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US9844757B2 (en) 2014-03-12 2017-12-19 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
USD734847S1 (en) * 2012-05-31 2015-07-21 Viacyte, Inc. Cell encapsulation device
EP2859091B1 (en) 2012-06-08 2018-08-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells
US20150320836A1 (en) * 2012-07-06 2015-11-12 The Regents Of The University Of California Cryopreservation of cells inside a macro-encapsulation device
WO2014033322A1 (en) 2012-09-03 2014-03-06 Novo Nordisk A/S Generation of pancreatic endoderm from pluripotent stem cells using small molecules
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
RU2658488C2 (ru) 2012-12-31 2018-06-21 Янссен Байотек, Инк. Способ получения клеток, экспрессирующих маркеры, характерные для панкреатических эндокринных клеток
CN105073979B (zh) 2012-12-31 2020-03-06 詹森生物科技公司 使用hb9调节子使人胚胎干细胞分化为胰腺内分泌细胞的方法
SG11201505119UA (en) 2012-12-31 2015-07-30 Janssen Biotech Inc Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
US20150368616A1 (en) * 2013-02-14 2015-12-24 The Cleveland Clinic Foundation Methods for induction of cell fates from pluripotent cells
CN105163688B (zh) * 2013-03-07 2018-11-20 韦尔赛特公司 三维大容量细胞包封装置组件
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
WO2014138671A2 (en) * 2013-03-08 2014-09-12 Viacyte, Inc. Cryopreservation, hibernation and room temperature storage of encapulated pancreatic endoderm cell aggregates
TW201504140A (zh) 2013-03-12 2015-02-01 Lockheed Corp 形成具有均勻孔尺寸之多孔石墨烯之方法
US8859286B2 (en) * 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
US9950149B2 (en) 2013-04-24 2018-04-24 Nestec S.A. Biomolecular cell encapsulation device and methods of implantation
KR102232650B1 (ko) 2013-06-11 2021-03-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
CA2917109C (en) * 2013-07-02 2022-11-01 Walter H. Guenzburg A method of freeze-drying encapsulated cells, freeze-dried encapsulated cells, compositions containning freeze-dried encapsulated cells and uses of such cells and compositions
MX2016003615A (es) 2013-09-24 2016-10-26 Giner Inc Sistema para tratamiento con gas de un implante de celulas.
SG11201606287VA (en) 2014-01-31 2016-08-30 Lockheed Corp Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
WO2015116946A1 (en) 2014-01-31 2015-08-06 Lockheed Martin Corporation Perforating two-dimensional materials using broad ion field
MX2016011812A (es) * 2014-03-12 2017-05-09 Lockheed Corp Uso in vivo e in vitro de grafeno.
JP6585615B2 (ja) 2014-03-21 2019-10-02 ライフ テクノロジーズ コーポレイション 流体処理システムのための凝縮器システム
EP3119504B1 (en) 2014-03-21 2020-10-14 Life Technologies Corporation Gas filter systems for fluid processing systems
US9950151B2 (en) * 2014-03-27 2018-04-24 Beta-O2 Technologies Ltd. Implantable medical devices
JP6691055B2 (ja) * 2014-04-16 2020-04-28 ヴィアサイト インコーポレイテッド 埋め込み可能な封入デバイスと共に使用するツールおよび器具
USD760399S1 (en) * 2014-04-16 2016-06-28 Viacyte, Inc. Case for an encapsulation device
US11051900B2 (en) * 2014-04-16 2021-07-06 Viacyte, Inc. Tools and instruments for use with implantable encapsulation devices
WO2015175776A1 (en) * 2014-05-14 2015-11-19 NuTech Medical, Inc. Placental membrane preparations and methods of making and using same for regenerating cartilage and spinal intervertebral discs
SG10201810739VA (en) 2014-05-16 2019-01-30 Janssen Biotech Inc Use of small molecules to enhance mafa expression in pancreatic endocrine cells
EP3147353B1 (en) * 2014-05-21 2022-03-30 Kyoto University Method for producing pancreatic blast cells and pancreatic disease treatment agent containing pancreatic blast cells
CN107073176B (zh) 2014-06-09 2021-02-19 康奈尔大学 可植入治疗递送系统及其方法
MX2017002738A (es) 2014-09-02 2017-08-02 Lockheed Corp Membranas de hemodialisis y hemofiltracion basadas en un material de membrana bidimensional y metodos que emplean las mismas.
ES2985135T3 (es) 2014-12-18 2024-11-04 Harvard College Procedimientos para generar células ß derivadas de células madre y usos de las mismas
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
WO2016100930A1 (en) * 2014-12-18 2016-06-23 President And Fellows Of Harvard College Methods for generating stem cell-derived b cells and methods of use thereof
CN107645952B (zh) 2015-03-23 2022-03-18 加利福尼亚大学董事会 薄膜细胞包囊装置
DK3286300T3 (da) 2015-04-24 2021-01-18 Univ Copenhagen Isolering af bona fide pankreatiske stamceller
WO2017023376A1 (en) 2015-08-05 2017-02-09 Lockheed Martin Corporation Perforatable sheets of graphene-based material
WO2017049008A1 (en) * 2015-09-16 2017-03-23 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
EP3167911A1 (en) * 2015-11-10 2017-05-17 Oniris Si-hpmc-encapsulated insulin-producing cells for the treatment of type 1 diabetes
EP3397389B1 (en) * 2015-12-29 2024-05-15 Life Technologies Corporation Method and system for separating magnetic particles from a fluid
JP2019501672A (ja) * 2016-01-12 2019-01-24 ステモニックス インコーポレイティド 細胞安定化のための細胞培地調合物
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
WO2017165850A1 (en) * 2016-03-25 2017-09-28 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
WO2017180139A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Two-dimensional membrane structures having flow passages
EP3443329A4 (en) 2016-04-14 2020-04-08 Lockheed Martin Corporation METHODS FOR PROVIDING IN SITU MONITORING AND CONTROL OF DEFECT TRAINING OR HEALING
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
WO2017180134A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
SG11201809016QA (en) 2016-04-14 2018-11-29 Lockheed Corp Selective interfacial mitigation of graphene defects
KR20190019907A (ko) 2016-04-14 2019-02-27 록히드 마틴 코포레이션 자유-플로팅 방법을 사용한 대규모 이송을 위한 그래핀 시트 취급 방법
CN116555028A (zh) 2016-07-12 2023-08-08 加州理工学院 用于高密度细胞生长和代谢物交换的基质
WO2018102077A2 (en) * 2016-11-03 2018-06-07 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, systems, and implantable devices for enhancing blood glucose regulation
SG10202104562TA (en) 2016-11-03 2021-06-29 Univ Arizona Stacked tissue encapsulation device systems with or without oxygen delivery
CN115322880A (zh) * 2016-11-03 2022-11-11 代表亚利桑那大学的亚利桑那董事会 用于在移植前后实时评估包封装置中细胞的方法和系统
CN110121312A (zh) 2016-11-03 2019-08-13 代表亚利桑那大学的亚利桑那董事会 有或无外源氧气输送的具有氧气传感器的包封装置的系统
US10849731B2 (en) 2016-11-08 2020-12-01 W. L. Gore & Associates, Inc. Cell encapsulation devices containing structural spacers
US11052230B2 (en) 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
USD824042S1 (en) 2016-11-10 2018-07-24 Viacyte, Inc. Perforated cell encapsulation device
CN115645621B (zh) 2016-11-10 2024-08-13 韦尔赛特公司 含有pdx1胰腺内胚层细胞的细胞递送装置及其方法
AU2017362331B2 (en) 2016-11-15 2023-07-20 Giner, Inc. Self-regulating electrolytic gas generator and implant system comprising the same
US11033666B2 (en) 2016-11-15 2021-06-15 Giner Life Sciences, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
CN108148808B (zh) * 2016-12-05 2020-12-11 同济大学 有助于诱导生成神经前体细胞的诱导培养基
EP3591040A4 (en) * 2017-03-03 2020-11-11 Kyoto University METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS
US12016327B2 (en) * 2017-03-20 2024-06-25 Boston Scientific Medical Device Limited Cell encapsulation device
CN110831656A (zh) 2017-05-04 2020-02-21 吉纳生命科学公司 稳健的可植入气体递送装置和方法、系统以及包括该装置的装置
EP3409239A1 (en) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
JPWO2018230588A1 (ja) * 2017-06-14 2020-04-16 武田薬品工業株式会社 細胞封入デバイス
JP7284948B2 (ja) 2017-06-14 2023-06-01 バーテックス ファーマシューティカルズ インコーポレイテッド 療法薬を送達するためのデバイスおよび方法
KR102001120B1 (ko) 2017-06-29 2019-07-16 서울대학교산학협력단 나노섬유 및 하이드로젤의 복합체 및 이를 포함하는 조직 재생용 스캐폴드
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
JP6854904B2 (ja) 2017-08-30 2021-04-07 富士フイルム株式会社 血管新生剤およびその製造方法
CN111032099B (zh) 2017-08-30 2022-08-30 富士胶片株式会社 细胞移植用设备及其制造方法
EP3681992A1 (en) * 2017-09-11 2020-07-22 Novo Nordisk A/S Enrichment of nkx6.1 and c-peptide co-expressing cells derived in vitro from stem cells
AU2018342581B2 (en) 2017-09-29 2024-06-20 Vertex Pharmaceuticals Incorporated Cell housing device
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
MX2020004939A (es) * 2017-11-15 2020-11-11 Semma Therapeutics Inc Fabricacion de composiciones de celulas islote y metodos de uso de las mismas.
JP2019097442A (ja) 2017-11-30 2019-06-24 株式会社日立製作所 免疫隔離デバイス
JP6417023B2 (ja) * 2017-12-20 2018-10-31 ネステク ソシエテ アノニム カプセル化デバイス
CN108543116B (zh) * 2018-05-02 2021-04-27 深圳市华异生物科技有限责任公司 海藻酸钠与明胶复合水凝胶3d胰岛支架及其制备方法
JP7486435B2 (ja) 2018-05-17 2024-05-17 ガイナー,インク. リードターミナルとガスポートターミナルとを組み合わせた電解ガス発生装置
EP3831931A4 (en) * 2018-08-03 2022-05-18 Kyoto University Cell production method
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
US11963862B2 (en) 2018-08-22 2024-04-23 Boston Scientific Scimed, Inc. Cell encapsulation device including a porous tube
WO2020047369A2 (en) * 2018-08-30 2020-03-05 The Curators Of The University Of Missouri An efficient cryopreservation device preventing the direct contact between samples and extracelluar ice
US20200080107A1 (en) 2018-09-07 2020-03-12 Crispr Therapeutics Ag Universal donor cells
WO2020068852A1 (en) * 2018-09-24 2020-04-02 Procyon Technologies Llc Methods and systems for implantable medical devices and vascularization membranes
JP7280352B2 (ja) * 2018-09-26 2023-05-23 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド 細胞床厚が制御された細胞カプセル化デバイス
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
CA3116184A1 (en) * 2018-10-15 2020-04-23 Cynity Co., Ltd. Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
CN109289090A (zh) * 2018-10-31 2019-02-01 陈津 一种胰岛移植微环境及其构建方法
EP3903881A4 (en) * 2018-12-25 2022-01-19 FUJIFILM Corporation CELL TRANSPLANT KIT, METHOD FOR MAKING POUCH-LIKE STRUCTURE, AND THERAPEUTIC AGENT FOR DIABETES
JP7267377B2 (ja) * 2019-02-25 2023-05-01 ヴィアサイト インコーポレイテッド 埋め込み可能な封入デバイスと共に使用するツールおよび器具
JP6970245B2 (ja) * 2019-02-25 2021-11-24 ヴィアサイト インコーポレイテッド 埋め込み可能な封入デバイスと共に使用するツールおよび器具
CN113710199B (zh) * 2019-04-03 2025-01-28 沃泰克斯药物股份有限公司 多隔室大胶囊装置
WO2020243663A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
JP2022534545A (ja) 2019-05-31 2022-08-01 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド 生体適合性メンブレン複合体
WO2020243668A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
AU2020340622A1 (en) 2019-09-05 2022-03-03 Crispr Therapeutics Ag Universal donor cells
US11118195B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
KR20220070474A (ko) * 2019-09-27 2022-05-31 이슬라 테크놀로지스, 인크. 생체인공 췌장
WO2022047543A1 (en) * 2020-09-04 2022-03-10 Captix Biomedical Pty Ltd "bone implant"
CA3196876A1 (en) 2020-10-30 2022-05-05 Klearchos Papas Methods and systems for encapsulation devices for housing cells and agents
CN112544613B (zh) * 2020-12-25 2022-08-16 武汉睿健医药科技有限公司 一种多能干细胞冻存液、其应用及冻存方法
JP2024503290A (ja) 2020-12-31 2024-01-25 クリスパー セラピューティクス アクチェンゲゼルシャフト ユニバーサルドナー細胞
CN118338865A (zh) * 2021-08-10 2024-07-12 马斯特里赫特大学 开放式可植入细胞递送装置
EP4482465A2 (en) 2022-02-25 2025-01-01 ViaCyte, Inc. Multilayer implantable cell encapsulation devices and methods thereof
EP4511475A1 (en) 2022-04-21 2025-02-26 Evotec International GmbH New cell populations and means and methods for their differentiation and preservation
US12139696B2 (en) 2022-08-19 2024-11-12 Dimension Inx Corp. Biointegrative implantable cell encapsulation device and system
WO2024073711A1 (en) 2022-09-30 2024-04-04 W.L. Gore & Associates, Inc. Implantable membrane construct and encapsulaton devices incorporating the same
WO2024081309A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
WO2024081310A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
JP7451818B1 (ja) 2023-11-10 2024-03-18 洋之 高尾 Diffusion Chamber型人工膵島器

Family Cites Families (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500388A (en) 1948-07-21 1950-03-14 Minnesota Mining & Mfg Fluorocarbon ethers
US2594272A (en) 1948-09-10 1952-04-29 Minnesota Mining & Mfg Cyclic fluoroalkylene oxide compounds
US2519983A (en) 1948-11-29 1950-08-22 Minnesota Mining & Mfg Electrochemical process of making fluorine-containing carbon compounds
US2616927A (en) 1950-05-12 1952-11-04 Minnesota Mining & Mfg Fluorocarbon tertiary amines
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4542104A (en) * 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4723953A (en) * 1985-01-07 1988-02-09 Rocky Mountain Medical Corporation Absorbent pad
US4788339A (en) 1985-09-06 1988-11-29 Minnesota Mining And Manufacturing Company Perfluoroaminoethers
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5182111A (en) 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5418154A (en) 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5219361A (en) 1988-09-16 1993-06-15 Clemson University Soft tissue implant with micron-scale surface texture to optimize anchorage
US5011494A (en) 1988-09-16 1991-04-30 Clemson University Soft tissue implant with micron-scale surface texture to optimize anchorage
CA1335181C (en) 1988-10-11 1995-04-11 R. Alan Hardwick System for selective cell separation from cell concentrate
EP0452342B1 (en) 1988-12-28 1994-11-30 MILTENYI, Stefan Methods and materials for high gradient magnetic separation of biological materials
US5116493A (en) 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5002661A (en) 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5100392A (en) * 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
US5171846A (en) * 1990-05-21 1992-12-15 Coulter Corporation Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use
US5272257A (en) * 1990-05-21 1993-12-21 Coulter Corporation Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use
US5240640A (en) * 1990-06-04 1993-08-31 Coulter Corporation In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5713888A (en) 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5466609A (en) * 1990-10-31 1995-11-14 Coulter Corporation Biodegradable gelatin-aminodextran particle coatings of and processes for making same
US5314471A (en) 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
US5344454A (en) 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
ES2090364T3 (es) 1990-10-31 1996-10-16 Baxter Int Material de implante de vascularizacion cercana.
US5545223A (en) * 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
US5639620A (en) * 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
JP3502093B2 (ja) 1991-07-15 2004-03-02 ザ・ウエルカム・ファウンデーション・リミテッド 抗体の製造
US5453278A (en) 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
JPH06502577A (ja) 1991-07-30 1994-03-24 バクスター、インターナショナル、インコーポレイテッド 有孔埋め込み物
JPH0613739Y2 (ja) * 1991-09-26 1994-04-13 富士システムズ株式会社 人工臓器用カプセル及び人工臓器
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US6165993A (en) 1992-03-23 2000-12-26 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
AU4114993A (en) * 1992-04-24 1993-11-29 Polymer Technology Group, Inc., The Biocompatible, therapeutic, implantable device
US5690926A (en) * 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US7153684B1 (en) 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5262055A (en) * 1992-10-19 1993-11-16 The University Of Utah Implantable and refillable biohybrid artificial pancreas
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
JPH10507997A (ja) * 1993-06-11 1998-08-04 クールター コーポレイション T細胞の活性化および増殖を誘導するための抗cd3抗体−アミノデキストラン結合体
CN1129402A (zh) * 1993-06-23 1996-08-21 布朗大学研究基金会 密封可植入的薄膜封装件的方法和装置
EP0670738A1 (en) 1993-09-24 1995-09-13 Baxter International Inc. Methods for enhancing vascularization of implant devices
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
US5421923A (en) 1993-12-03 1995-06-06 Baxter International, Inc. Ultrasonic welding horn with sonics dampening insert
US5549675A (en) * 1994-01-11 1996-08-27 Baxter International, Inc. Method for implanting tissue in a host
US6156305A (en) 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
US5989833A (en) * 1994-09-20 1999-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for detection of molecules with affinity for MPL polypeptides
US5807406A (en) 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5705059A (en) 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
WO1996032076A1 (en) 1995-04-11 1996-10-17 Baxter Internatonal Inc. Tissue implant systems
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
AU6251196A (en) * 1995-06-07 1996-12-30 Gore Hybrid Technologies, Inc. An implantable containment apparatus for a therapeutical dev ice and method for loading and reloading the device therein
WO1997010807A1 (en) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US6251671B1 (en) * 1996-02-28 2001-06-26 Vanderbilt University Compositions and methods of making embryonic stem cells
US5964261A (en) * 1996-05-29 1999-10-12 Baxter International Inc. Implantation assembly
AU5734998A (en) 1997-01-10 1998-08-03 Life Technologies, Inc. Embryonic stem cell serum replacement
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
AU754425B2 (en) 1997-09-15 2002-11-14 Genetic Immunity, Llc. Method of delivering genes to antigen presenting cells of the skin
US5945293A (en) * 1997-10-09 1999-08-31 Coulter International Corp. Protein-colloidal metal-aminodextran coated particle and methods of preparation and use
US6074884A (en) * 1997-10-09 2000-06-13 Coulter International Corp. Stable protein-nickel particles and methods of production and use thereof
WO1999020741A1 (en) * 1997-10-23 1999-04-29 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
WO1999053021A1 (en) 1998-04-09 1999-10-21 Bresagen Limited Cell differentiation/proliferation and maintenance factor and uses thereof
US6921811B2 (en) 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE19852800C1 (de) 1998-11-16 2000-04-13 Univ Albert Ludwigs Freiburg Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist
PT1435220E (pt) * 1998-12-15 2006-12-29 Univ Mexico Nacional Autonoma Processo e dispositivo para facilitar a implantação de material biológico
IL144654A0 (en) * 1999-02-10 2002-05-23 Curis Inc Pancreatic progenitor cells, methods and uses related thereto
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
US6520997B1 (en) 1999-12-08 2003-02-18 Baxter International Inc. Porous three dimensional structure
US6617151B1 (en) * 2000-02-29 2003-09-09 Gore Enterprise Holdings, Inc. Method of closing a cell containment device with a wet seal
US7005252B1 (en) * 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
IL154159A0 (en) 2000-08-01 2003-07-31 Yissum Res Dev Co Directed differentiation of ebryonic cells
WO2002034880A2 (en) 2000-10-23 2002-05-02 University Of Kansas Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion
WO2002055136A2 (en) * 2000-12-01 2002-07-18 Nephros Therapeutics Inc Intrasvascular drug delivery device and use therefor
US6616912B2 (en) 2001-01-05 2003-09-09 Spectrum Laboratories, Inc. Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells
WO2002059278A2 (en) 2001-01-24 2002-08-01 The Government Of The United States Of America, As Represented By The Secretary Of Department Of Health & Human Services Differentiation of stem cells to pancreatic endocrine cells
CA2450720A1 (en) 2001-06-13 2002-12-19 Massachusetts Institute Of Technology In vivo bioreactors
US6702857B2 (en) * 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US7432104B2 (en) 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
ATE532854T1 (de) * 2001-12-04 2011-11-15 Organogenesis Inc Kultivierte zellen aus den langerhansschen inseln
US7157278B2 (en) 2001-12-04 2007-01-02 Organogenesis, Inc. Cultured cells from pancreatic islets
EP2264146A1 (en) 2001-12-07 2010-12-22 Geron Corporation Islet cells from human embryonic stem cells
US20030138949A1 (en) 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US7101546B2 (en) * 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
CA2487058C (en) 2002-05-17 2015-04-14 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
US20060003446A1 (en) * 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2003100026A2 (en) 2002-05-28 2003-12-04 Novocell, Inc. Methods, compositions, and growth and differentiation factors for insulin-producing cells
CN1662643A (zh) 2002-05-28 2005-08-31 贝克顿·迪金森公司 人腺泡细胞的扩增和转分化
EP1553893A4 (en) * 2002-10-11 2010-09-22 Novocell Inc IMPLANTATION OF CAPTURED BIOLOGICAL MATERIAL FOR THE TREATMENT OF DISEASES
WO2004050827A2 (en) 2002-12-05 2004-06-17 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
CA2515108A1 (en) 2003-02-07 2004-08-26 Wisconsin Alumni Research Foundation Directed genetic modifications of human stem cells
US20070154981A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
KR20060010820A (ko) 2003-05-20 2006-02-02 도꾸리쯔교세이호징 리가가쿠 겐큐소 내배엽계 줄기세포의 제조
WO2005017131A2 (en) 2003-08-14 2005-02-24 THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES Methods for the differentiation of human stem cells
JP2007503815A (ja) 2003-08-27 2007-03-01 ステムセルズ・カリフォルニア・インコーポレイテッド 富化された膵臓幹細胞および前駆細胞集団、ならびにこれらの集団の同定、単離および富化方法
WO2005033294A2 (en) 2003-09-30 2005-04-14 Regents Of The University Of California Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage
WO2005059095A2 (en) * 2003-12-10 2005-06-30 The General Hospital Corporation Expansion and differentiation of islet progenitor cells
US7625753B2 (en) * 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
JP4819697B2 (ja) 2003-12-23 2011-11-24 ヴィアサイト,インコーポレイテッド 胚体内胚葉
US7541185B2 (en) * 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US20050191282A1 (en) * 2004-03-01 2005-09-01 Opara Emmanuel C. Method of cryopreserving pancreatic islet cells
US20060281174A1 (en) 2004-03-09 2006-12-14 Gang Xu Methods for generating insulin-producing cells
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
CA2555571C (en) 2004-04-01 2012-10-16 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage
CN103103158B (zh) 2004-04-27 2016-08-03 韦尔赛特公司 细胞培养基
CN100457900C (zh) * 2004-06-29 2009-02-04 天津大学 细胞和组织移植用金属微囊
DK1773986T3 (en) 2004-07-09 2019-04-08 Viacyte Inc PRE-PRIMATIVE STRIP AND MESENDODERM CELLS
JP5687816B2 (ja) 2004-07-09 2015-03-25 ヴィアサイト,インコーポレイテッド 胚体内胚葉を分化させるための因子を同定する方法
EP1791952A4 (en) 2004-08-13 2008-06-11 Univ Georgia Res Found COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS
US20060063141A1 (en) * 2004-09-17 2006-03-23 Mcgann Locksley E Method of cryopreserving cells
JP2008514214A (ja) 2004-09-29 2008-05-08 セルアーティス アーベー ヒト胚盤胞由来幹細胞(hBS)から肝細胞様細胞を発生させる方法
JP2008538276A (ja) * 2005-01-28 2008-10-23 ノヴァセラ・リミテッド 胚幹細胞培養のための方法
CA2613812A1 (en) 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
US20060182722A1 (en) * 2005-02-11 2006-08-17 Hering Bernhard J Methods and materials for isolating isogenic islet cells
CN100425694C (zh) 2005-04-15 2008-10-15 北京大学 诱导胚胎干细胞向胰腺细胞分化的方法
WO2007002210A2 (en) 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
JP5404047B2 (ja) * 2005-10-27 2014-01-29 ヴィアサイト,インコーポレイテッド Pdx1発現背側及び腹側前腸内胚葉
GB0522564D0 (en) * 2005-11-04 2005-12-14 Reneuron Ltd Cells
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
CN102389344B (zh) 2006-02-07 2015-12-16 脊柱赛特有限公司 采用机械应变使人皮肤成纤维细胞发生软骨形成分化的方法
SG170021A1 (en) 2006-02-23 2011-04-29 Novocell Inc Compositions and methods useful for culturing differentiable cells
CA3147112A1 (en) * 2006-03-02 2007-09-13 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US7695965B2 (en) * 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
MY154677A (en) * 2006-03-07 2015-07-15 Shroff Geeta Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
US20070237749A1 (en) * 2006-04-07 2007-10-11 Wang Taylor G Multi-membrane immunoisolation system for cellular transplant
US8741643B2 (en) * 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2008013664A2 (en) * 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
WO2008052046A2 (en) * 2006-10-24 2008-05-02 Case Western Reserve University Compositions for coating cell membranes and methods of use thereof
US20080241250A1 (en) 2006-11-08 2008-10-02 Emans Pieter J In vivo bioreactors and methods of making and using same
CN101611133A (zh) * 2006-12-07 2009-12-23 威尔森沃尔夫制造公司 高效装置及培养细胞的方法
US20080279833A1 (en) 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
US7695963B2 (en) * 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US8623650B2 (en) * 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
WO2009059072A2 (en) 2007-10-30 2009-05-07 Tufts University Analysis of endogenous fluorescence images to extract morphological/organization information about living samples
US8338170B2 (en) * 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8008075B2 (en) * 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト,インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
DK3290061T3 (da) 2009-08-28 2020-07-13 Sernova Corp Fremgangsmåder og anordninger til cellulær transplantation
BR112012017761A2 (pt) 2009-12-23 2015-09-15 Centocor Ortho Biotech Inc diferenciação das células-tronco embrionárias humanas
SG185511A1 (en) 2010-05-12 2012-12-28 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
US10702008B2 (en) 2018-02-26 2020-07-07 Hbn Shoe, Llc Device and method of constructing shoes
US11586805B2 (en) 2021-07-26 2023-02-21 Atlassian Pty Ltd. Machine-learning-based natural language processing techniques for low-latency document summarization

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