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PE49195A1 - Inhibidor de proteinquinasa - Google Patents

Inhibidor de proteinquinasa

Info

Publication number
PE49195A1
PE49195A1 PE1994256342A PE25634294A PE49195A1 PE 49195 A1 PE49195 A1 PE 49195A1 PE 1994256342 A PE1994256342 A PE 1994256342A PE 25634294 A PE25634294 A PE 25634294A PE 49195 A1 PE49195 A1 PE 49195A1
Authority
PE
Peru
Prior art keywords
proteinquinase
inhibitor
indolemaleimide
mammals
chem
Prior art date
Application number
PE1994256342A
Other languages
English (en)
Inventor
Jr William Francis Heath
Christopher John Rito
Michael Robert Jirousek
Iii John Hampton Mcdonald
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE49195A1 publication Critical patent/PE49195A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DERIVADO DE INDOL DE FORMULA I DONDE: 1) W ES -O-, -S-, -SO-, -SO2, -CO-, ALQUILENO C2-C6, ALQUILENO SUSTITUIDO, ALQUENILENO C2-C6, -ARILO-, -ARIL(CH2)mO-, -HETEROCICLO-, -HETEROCICLO-(CH2)mO-, -BICICLICO FUNDIDO-, -BICICLICO FUNDICO-(CH2)mO-, -NR3-, -NOR3-, -CONH-, o -NHCO-; 2) X E Y SON ALQUILENO C1-C4, ALQUILENO SUSTITUIDO, o X, Y Y W JUNTOS SE COMBINAN PARA FORMAR -(CH2)n-AA-; 3) R1 ES HIDROGENO, HALO, ALQUILO C1-C4, HIDROXI, ALCOXILO C1-C4, HALOALQUILO, NITRO, NR4R5, o -NHCO(ALQUILO C1-C4); 4) R2 ES HIDROGENO, CH3CO-, NH2, o HIDROXI; 5) R3 ES HIDROGENO, (CH2)m-ARILO, ALQUILO C1-C4, -COO(ALQUILO C1-C4), -CONR4R5, -(C=NH)NH2, -SO(ALQUILO C1-C4), -SO2(NR4R5), o -SO2(ALQUILO C1-C4); 6) R4 Y R5 SON HIDROGENO, ALQUILO C1-C4, FENILO, BENCILO, o SE COMBINAN CON EL NITROGENO AL QUE ESTAN UNIDOS PARA FORMAR UN ANILLO DE 5 o 6 MIEMBROS SATURADO o INSATURADO; 7) AA ES UN RESTO AMINOACIDO; 8) m ES 0, 1, 2 o 3; Y n ES 2, 3, 4 o 5; EL CUAL ES UN INHIBIDOR DE LA ENZIMA PROTEINQUINASA, DE PREFERENCIA DE LAS ISOZIMAS �1 Y �2 Y PUEDE SER UTIL EN EL TRATAMIENTO DE ESTADOS EN LOS QUE LA PROTEINQUINASA SE HA RELACIONADO CON LA PATOLOGIA TAL COMO DIABETES MELLITUS, ISQUEMIA, INFLAMACION, TRANSTORNOS DEL SISTEMA NERVIOSO CENTRAL, ENFERMEDAD CARDIOVASCULAR, ENFERMEDAD DERMATOLOGICA Y CANCER
PE1994256342A 1993-12-07 1994-12-02 Inhibidor de proteinquinasa PE49195A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16306093A 1993-12-07 1993-12-07
US31697394A 1994-10-03 1994-10-03

Publications (1)

Publication Number Publication Date
PE49195A1 true PE49195A1 (es) 1996-01-06

Family

ID=26859318

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994256342A PE49195A1 (es) 1993-12-07 1994-12-02 Inhibidor de proteinquinasa

Country Status (31)

Country Link
US (1) US5698578A (es)
EP (1) EP0657458B1 (es)
JP (2) JP3581731B2 (es)
KR (1) KR100340159B1 (es)
CN (2) CN1050844C (es)
AT (1) ATE204579T1 (es)
AU (1) AU687909B2 (es)
BR (1) BR9404831A (es)
CA (1) CA2137203C (es)
CO (1) CO4340622A1 (es)
CY (1) CY2413B1 (es)
CZ (1) CZ291950B6 (es)
DE (1) DE69428025T2 (es)
DK (1) DK0657458T3 (es)
ES (1) ES2162843T3 (es)
FI (3) FI108138B (es)
GR (1) GR3037087T3 (es)
HK (1) HK1013827A1 (es)
HU (1) HU219709B (es)
IL (1) IL111850A (es)
MY (1) MY125587A (es)
NO (1) NO308798B1 (es)
NZ (1) NZ270048A (es)
PE (1) PE49195A1 (es)
PL (1) PL182124B1 (es)
PT (1) PT657458E (es)
RU (1) RU2147304C1 (es)
SG (1) SG63570A1 (es)
TW (1) TW425397B (es)
UA (1) UA44690C2 (es)
YU (1) YU49200B (es)

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EP0657458B1 (en) 2001-08-22
ES2162843T3 (es) 2002-01-16
CZ291950B6 (cs) 2003-06-18
PT657458E (pt) 2002-02-28
YU70494A (sh) 1997-03-07
BR9404831A (pt) 1995-08-08
AU7918894A (en) 1995-06-15
CN1220266A (zh) 1999-06-23
CO4340622A1 (es) 1996-07-30
CN1111247A (zh) 1995-11-08
CZ301894A3 (en) 1995-06-14
DE69428025T2 (de) 2002-05-29
KR100340159B1 (ko) 2002-11-23
YU49200B (sh) 2004-09-03
CN1050844C (zh) 2000-03-29
RU94042922A (ru) 1996-12-27
FI20011109A (fi) 2001-05-28
NO944643D0 (no) 1994-12-02
TW425397B (en) 2001-03-11
FI20000516A (fi) 2000-03-07
GR3037087T3 (en) 2002-01-31
US5698578A (en) 1997-12-16
MY125587A (en) 2006-08-30
HU9403468D0 (en) 1995-02-28
FI945706A0 (fi) 1994-12-02
ATE204579T1 (de) 2001-09-15
FI108138B (fi) 2001-11-30
DE69428025D1 (de) 2001-09-27
HK1013827A1 (en) 1999-09-10
FI945706A (fi) 1995-06-08
NZ270048A (en) 1996-11-26
KR950018010A (ko) 1995-07-22
CA2137203C (en) 2006-11-28
HU219709B (hu) 2001-06-28
JPH07215977A (ja) 1995-08-15
JP2004269543A (ja) 2004-09-30
IL111850A (en) 2002-11-10
SG63570A1 (en) 1999-03-30
PL182124B1 (pl) 2001-11-30
HUT71130A (en) 1995-11-28
IL111850A0 (en) 1995-03-15
CY2413B1 (en) 2004-11-12
RU2147304C1 (ru) 2000-04-10
AU687909B2 (en) 1998-03-05
NO308798B1 (no) 2000-10-30
NO944643L (no) 1995-06-08
PL306084A1 (en) 1995-06-12
EP0657458A1 (en) 1995-06-14
UA44690C2 (uk) 2002-03-15
DK0657458T3 (da) 2001-10-29
CA2137203A1 (en) 1995-06-08
CN1055089C (zh) 2000-08-02
JP3581731B2 (ja) 2004-10-27

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