[go: up one dir, main page]

PE20060358A1 - Cristal estable del compuesto 4-oxoquinolina - Google Patents

Cristal estable del compuesto 4-oxoquinolina

Info

Publication number
PE20060358A1
PE20060358A1 PE2005000561A PE2005000561A PE20060358A1 PE 20060358 A1 PE20060358 A1 PE 20060358A1 PE 2005000561 A PE2005000561 A PE 2005000561A PE 2005000561 A PE2005000561 A PE 2005000561A PE 20060358 A1 PE20060358 A1 PE 20060358A1
Authority
PE
Peru
Prior art keywords
crystal
stable crystal
oxoquinoline compound
diffration
forms
Prior art date
Application number
PE2005000561A
Other languages
English (en)
Inventor
Motohide Satoh
Takahisa Motomura
Kentaro Kondo
Koji Matsuda
Hideto Uehara
Shuji Miyake
Koji Ando
Takashi Matsuda
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35079161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060358(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PE20060358A1 publication Critical patent/PE20060358A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

REFERIDA A UN CRISTAL DEL ACIDO 6-(3-CLORO-2-FLUOROBENCIL)-1-[(S)-1-HIDROXIMETIL-2-METILPROPIL]-7-METOXI-4-OXO-1,4-DIHIDROQUINOLINA-3-CARBOXILICO, QUE MUESTRA PICOS MAXIMOS DE DIFRACCION CARACTERISTICOS A ANGULOS DE DIFRACCION 2q(°) MEDIDO MEDIANTE DIFRACTOMETRIA DE POLVO POR RAYOS-X, TALES COMO 6,56, 13,20, 19,86, 20,84, 21,22, 24,22. SON FORMAS CARACTERISTICAS DE ESTE CRISTAL, LAS FORMAS II Y III. DICHO CRISTAL PRESENTA UNA ESTABILIDAD FISICA Y QUIMICA MEJORADA
PE2005000561A 2004-05-20 2005-05-20 Cristal estable del compuesto 4-oxoquinolina PE20060358A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004150979 2004-05-20

Publications (1)

Publication Number Publication Date
PE20060358A1 true PE20060358A1 (es) 2006-05-12

Family

ID=35079161

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2011002129A PE20120361A1 (es) 2004-05-20 2005-05-20 Composiciones farmaceuticas que comprenden formas cristalinas de acido 6-(3-cloro-2-fluorobencil)-1-[(s)-1-hidroximetil-2-metilpropil]-7-metoxi-4-oxo-1, 4-dihidroquinolina-3-carboxilico
PE2005000561A PE20060358A1 (es) 2004-05-20 2005-05-20 Cristal estable del compuesto 4-oxoquinolina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2011002129A PE20120361A1 (es) 2004-05-20 2005-05-20 Composiciones farmaceuticas que comprenden formas cristalinas de acido 6-(3-cloro-2-fluorobencil)-1-[(s)-1-hidroximetil-2-metilpropil]-7-metoxi-4-oxo-1, 4-dihidroquinolina-3-carboxilico

Country Status (34)

Country Link
US (7) US7635704B2 (es)
EP (4) EP2514746A1 (es)
JP (1) JP3754064B2 (es)
KR (1) KR20080064909A (es)
CN (1) CN1956961B (es)
AR (2) AR049280A1 (es)
AU (1) AU2005245296B2 (es)
BE (1) BE2024C511I2 (es)
BR (1) BRPI0510114B8 (es)
CA (1) CA2566922C (es)
CY (4) CY1113010T1 (es)
DK (2) DK3281939T3 (es)
ES (2) ES2388441T3 (es)
FI (2) FI3281939T3 (es)
FR (1) FR23C1040I1 (es)
HK (1) HK1083341A1 (es)
HR (2) HRP20231588T3 (es)
HU (2) HUE064615T2 (es)
IL (1) IL179250A0 (es)
LT (1) LT3281939T (es)
LU (1) LUC00334I2 (es)
MX (1) MXPA06013405A (es)
MY (1) MY134672A (es)
NO (6) NO339223B1 (es)
NZ (1) NZ551839A (es)
PE (2) PE20120361A1 (es)
PL (2) PL3281939T3 (es)
PT (2) PT1636190E (es)
RS (2) RS52375B (es)
RU (1) RU2330845C1 (es)
SI (2) SI1636190T1 (es)
TW (1) TWI329015B (es)
WO (1) WO2005113508A1 (es)
ZA (1) ZA200610647B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891227B2 (en) 2002-03-20 2005-05-10 International Business Machines Corporation Self-aligned nanotube field effect transistor and method of fabricating same
TR200401663T1 (tr) * 2002-11-20 2005-04-21 Japan Tobacco Inc. 4-oksokuinolin bileşiği ve bunun HIV integraz inhibitörü olarak kullanımı.
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
WO2007063869A1 (ja) * 2005-11-30 2007-06-07 Japan Tobacco Inc. 高純度キノロン化合物の製造方法
EA018544B1 (ru) * 2005-12-30 2013-08-30 Джилид Сайэнс, Инк. Способ лечения ретровирусной инфекции
AU2013203476C1 (en) * 2005-12-30 2016-11-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
US20090233964A1 (en) * 2005-12-30 2009-09-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
JP2009525261A (ja) * 2006-02-01 2009-07-09 日本たばこ産業株式会社 レトロウイルス感染症の治療のための、６−（３−クロロ−２−フルオロベンジル）−１−［（２ｓ）−１−ヒドロキシ−３−メチルブタン−２−イル］−７−メトキシ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸またはその塩の使用
WO2007092802A1 (en) * 2006-02-09 2007-08-16 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and gs 9137
WO2007102499A1 (ja) 2006-03-06 2007-09-13 Japan Tobacco Inc. ４－オキソキノリン化合物の製造方法
ES2531190T3 (es) * 2006-03-06 2015-03-11 Japan Tobacco Inc Método para producir un compuesto de 4-oxoquinolina
EA020489B1 (ru) 2006-07-07 2014-11-28 Джилид Сайэнс, Инк. Модуляторы фармакокинетических свойств лекарственных средств
JP5221544B2 (ja) 2006-09-12 2013-06-26 ギリアード サイエンシーズ， インコーポレイテッド インテグラーゼ阻害剤を調製するためのプロセスおよび中間体
CN101679325B (zh) 2007-02-23 2013-08-28 吉里德科学公司 治疗剂的药代动力学特性调节剂
JP5547067B2 (ja) * 2007-06-29 2014-07-09 ギリアード サイエンシーズ， インコーポレイテッド 治療組成物およびその使用
US20090093467A1 (en) * 2007-06-29 2009-04-09 Gilead Sciences, Inc. Therapeutic compositions and methods
AR068403A1 (es) * 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
CN103479584A (zh) 2008-05-02 2014-01-01 吉里德科学公司 固体载体颗粒在改善药物制剂加工性中的应用
CN102307573B (zh) 2009-02-06 2013-09-11 吉里德科学公司 用于联合治疗的片剂
WO2010137032A2 (en) * 2009-05-14 2010-12-02 Matrix Laboratories Ltd. Novel polymorphic forms of elvitegravir and its pharmaceutically acceptable salts
WO2011004389A2 (en) * 2009-06-18 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of elvitegravir
CN102212032B (zh) * 2011-04-20 2013-07-31 复旦大学 一种5-羟基喹诺酮类衍生物及其制备方法和用途
KR101663436B1 (ko) 2012-07-06 2016-10-06 제넨테크, 인크. N-치환된 벤즈아미드 및 이의 사용 방법
WO2014022707A1 (en) 2012-08-03 2014-02-06 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
CN103819402B (zh) * 2012-11-17 2016-03-30 上海迪赛诺化学制药有限公司 埃替拉韦中间体及其制备方法和应用
CN103864682B (zh) * 2012-12-18 2016-12-28 上海迪赛诺化学制药有限公司 一种制备iii型埃替拉韦晶体的方法
DK3608325T3 (da) 2012-12-21 2022-08-22 Gilead Sciences Inc Polycykliske-carbamoylpyridonforbindelser og deres farmaceutiske anvendelse
EP3019503B1 (en) 2013-07-12 2017-09-06 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections
NO2865735T3 (es) 2013-07-12 2018-07-21
CN105315203A (zh) * 2014-06-06 2016-02-10 上海迪赛诺化学制药有限公司 一种v型埃替拉韦晶体及其制备方法
NO2717902T3 (es) 2014-06-20 2018-06-23
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
WO2016161382A1 (en) 2015-04-02 2016-10-06 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
CN106008195B (zh) * 2016-05-19 2018-08-03 绍兴文理学院 一种2，4-二氟-5-碘苯甲酸的制备方法
EP3984536A1 (en) * 2020-10-19 2022-04-20 Centre national de la recherche scientifique Inhibition of the hiv-1 replication by compounds directed against a new target of the viral cycle

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472859A (en) * 1966-11-01 1969-10-14 Sterling Drug Inc 1-alkyl-1,4-dihydro-4-oxo-3 quinoline-carboxylic acids and esters
JPS567162B1 (es) 1970-09-14 1981-02-16
JPS4826772A (es) 1971-08-11 1973-04-09
JPS6450979A (en) 1987-08-21 1989-02-27 Hitachi Shipbuilding Eng Co Method for discriminating whistle sound
JPH0651229B2 (ja) 1989-07-31 1994-07-06 新日本製鐵株式会社 プラズマアーク溶接方法および装置
IL100555A (en) 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
JP2993316B2 (ja) 1992-05-27 1999-12-20 宇部興産株式会社 アリール基又は複素芳香環基置換アミノキノロン誘導体及びエイズ治療剤
JPH06199835A (ja) 1993-01-08 1994-07-19 Hokuriku Seiyaku Co Ltd ８−ジフルオロメトキシキノリン−３−カルボン酸誘導体
JPH06271568A (ja) 1993-03-22 1994-09-27 Hokuriku Seiyaku Co Ltd ７−フェニルピペラジニルキノリン−３−カルボン酸誘導体
JP2930539B2 (ja) 1994-07-18 1999-08-03 三共株式会社 トリフルオロメチルキノリンカルボン酸誘導体
CA2194435A1 (en) 1994-07-18 1996-02-01 Tomio Kimura Trifluoromethylquinolinecarboxylic acid derivative
JPH0826772A (ja) 1994-07-22 1996-01-30 Sony Corp 融着用ガラス、その製造方法及び製造装置、並びに磁気ヘッドの製造方法
AU725629B2 (en) 1996-04-12 2000-10-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Acridone-derived compounds useful as antineoplastic and antiretroviral agents
FR2761687B1 (fr) * 1997-04-08 2000-09-15 Centre Nat Rech Scient Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques
JP3776203B2 (ja) 1997-05-13 2006-05-17 第一製薬株式会社 Ｉｃａｍ−１産生阻害剤
GB9721964D0 (en) 1997-10-16 1997-12-17 Pfizer Ltd Isoquinolines
US6399629B1 (en) 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
US6248739B1 (en) 1999-01-08 2001-06-19 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
US6248736B1 (en) 1999-01-08 2001-06-19 Pharmacia & Upjohn Company 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
PE20011349A1 (es) 2000-06-16 2002-01-19 Upjohn Co 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
ATE345129T1 (de) 2000-10-12 2006-12-15 Merck & Co Inc Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
CA2425067A1 (en) 2000-10-12 2002-05-10 Merck & Co., Inc. Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors
DE60229364D1 (de) 2001-03-01 2008-11-27 Shionogi & Co Stickstoffhaltige heteroarylverbindungen mit hiv-integrase inhibierender wirkung
JP2002293745A (ja) 2001-03-29 2002-10-09 St Marianna Univ School Of Medicine 慢性関節リウマチ治療剤
US20030138483A1 (en) * 2001-05-25 2003-07-24 Sergio Petriconi Soft elastic capsules and compositions thereof
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
FR2827600A1 (fr) 2001-07-20 2003-01-24 Lipha Derives acides de quinolone et leurs applications en therapeutique
JP4035765B2 (ja) 2002-10-31 2008-01-23 横河電機株式会社 フーリエ変換型赤外線分光計
JP3567162B1 (ja) 2002-11-20 2004-09-22 日本たばこ産業株式会社 ４−オキソキノリン化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
TR200401663T1 (tr) 2002-11-20 2005-04-21 Japan Tobacco Inc. 4-oksokuinolin bileşiği ve bunun HIV integraz inhibitörü olarak kullanımı.
US7531554B2 (en) * 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
EP3287130A1 (en) 2004-05-21 2018-02-28 Japan Tobacco Inc. Combinations comprising a 4-isoquinolone derivative and protease inhibitors

Also Published As

Publication number Publication date
FIC20240008I1 (fi) 2024-03-20
NO20230913A1 (no) 2007-02-07
WO2005113508A1 (en) 2005-12-01
US20100204271A1 (en) 2010-08-12
CY2024008I2 (el) 2024-09-20
NO347902B1 (no) 2024-05-06
NO339223B1 (no) 2016-11-21
EP3281939B1 (en) 2023-10-18
FI3281939T3 (fi) 2023-10-23
NO20065790L (no) 2007-02-07
FR23C1040I1 (fr) 2023-12-29
CY2015009I1 (el) 2024-09-20
BRPI0510114B1 (pt) 2020-09-15
AU2005245296B2 (en) 2010-08-12
CA2566922C (en) 2011-01-11
AU2005245296A1 (en) 2005-12-01
EP3281939A1 (en) 2018-02-14
SI3281939T1 (sl) 2024-02-29
HUE064615T2 (hu) 2024-04-28
DK3281939T3 (da) 2024-01-22
RU2330845C1 (ru) 2008-08-10
HUS2400006I1 (hu) 2024-04-28
US20250091995A1 (en) 2025-03-20
CN1956961A (zh) 2007-05-02
JP2006001927A (ja) 2006-01-05
TWI329015B (en) 2010-08-21
SI1636190T1 (sl) 2012-09-28
US20180029989A1 (en) 2018-02-01
RS52375B (en) 2012-12-31
KR20080064909A (ko) 2008-07-09
US20060030710A1 (en) 2006-02-09
PL3281939T3 (pl) 2024-03-18
TW200600097A (en) 2006-01-01
CY2024008I1 (el) 2024-09-20
CY1113010T1 (el) 2016-04-13
CY1126560T1 (el) 2024-09-20
ES2388441T3 (es) 2012-10-15
PL1636190T3 (pl) 2012-10-31
US7635704B2 (en) 2009-12-22
PE20120361A1 (es) 2012-05-03
PT3281939T (pt) 2023-11-22
EP4299563A3 (en) 2024-02-28
BE2024C511I2 (es) 2024-10-08
NZ551839A (en) 2009-11-27
US8981103B2 (en) 2015-03-17
DK1636190T3 (da) 2012-09-24
CN1956961B (zh) 2010-05-26
ZA200610647B (en) 2008-06-25
PT1636190E (pt) 2012-08-20
HRP20231588T3 (hr) 2024-03-15
EP1636190A1 (en) 2006-03-22
BRPI0510114A (pt) 2007-09-25
NO20200873A1 (no) 2007-02-07
LT3281939T (lt) 2023-11-27
NO20220690A1 (no) 2007-02-07
US20220235009A1 (en) 2022-07-28
BRPI0510114B8 (pt) 2021-05-25
CA2566922A1 (en) 2005-12-01
EP2514746A1 (en) 2012-10-24
NO20190051A1 (no) 2007-02-07
AR049280A1 (es) 2006-07-12
AR096100A2 (es) 2015-12-09
US20190185433A1 (en) 2019-06-20
EP1636190B1 (en) 2012-06-27
MXPA06013405A (es) 2007-03-01
LUC00334I2 (es) 2024-07-01
HK1083341A1 (en) 2006-06-30
ES2960824T3 (es) 2024-03-06
EP4299563A2 (en) 2024-01-03
CY2015009I2 (el) 2024-09-20
JP3754064B2 (ja) 2006-03-08
US20150361044A1 (en) 2015-12-17
IL179250A0 (en) 2007-03-08
MY134672A (en) 2007-12-31
HRP20120681T1 (hr) 2012-09-30
NO20161297A1 (no) 2007-02-07
RS64845B1 (sr) 2023-12-29

Similar Documents

Publication Publication Date Title
PE20060358A1 (es) Cristal estable del compuesto 4-oxoquinolina
UY38793A (es) Compuestos químicos
UY28760A1 (es) Compuestos de triazol y su uso como antagonistas del receptor de glutamato metabotrópico
CY1116315T1 (el) Παραγωγα κιναζολιν-4(3η)-ονης που χρησιμοποιουνται ως αναστολεις κινασης ρι3
RS54123B1 (en) THERAPEUTIC COMBINATION CONTAINING DOLUTEGRAVIR, ABACAVIR AND LAMIVUDINE
CR20120158A (es) Compuestos de diòxido de iminotiadiazina como inhibidores de bace, composiciones y su uso.
BR112013004220A2 (pt) fenilamidinas tendo uma atividade fungicida alta e seu uso.
ATE483707T1 (de) 2-cyclopropylthiazolderivate
MX375507B (es) Uso de derivados del ácido tetrámico como nematicidas.
CL2015002606A1 (es) Compuesto.
UA107951C2 (xx) Похідні імідазопіридину як інгібітори jak
EA200901109A1 (ru) Применение n-фениламидинов в качестве гербицидов
SMT201400008B (it) Uso di betanecolo per il trattamento di xerostomia
MX346393B (es) Nuevos antagonistas del receptor ccr2 y usos de los mismo.
CR20120427A (es) Derivados de pirazol como inhibidores de jak
CL2008000690A1 (es) Compuestos derivados del acido indol-3-propionico; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hiperlipidemia, hipertension; entre otras.
BR112012024796A2 (pt) inibidores de integrase macrocíclicos
CR20120634A (es) Derivados de heteroaril imidazolona como inhibidores de jak
CL2013001295A1 (es) Compuestos derivados de 2,3-dihidromidazo (1,2-c) quinazolina sustituidos con aminoalcoholes; compuesto intermediario y su uso; composicion farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogenesis.
PA8784001A1 (es) Oxazolidinonas sustituidas y su uso
CU23944B1 (es) Amidas del ácido pirrolidin-1,2-dicarboxílico sustituidas como moduladores de calicreína 7
CL2014000849A1 (es) Compuestos derivados de benzilindazoles sustituido, inhibidores de la quinasa bub1; procedimiento de fabricacion; composicion farmaceutica; combinacion farmaceutica; y su uso en el tratamiento de enfermedades hiperproliferativas.
MX2015014336A (es) Derivados de glutarimida, uso de los mismos, composicion farmaceutica basada en los mismos y metodos para producir derivados de glutarimida.
CR20140263A (es) Composicion herbicida que contiene acido de 4-amino-3-cloro-6-(-4-cloro-2-fluor-3-metoxifenil) piridina-2-carboxilico, o los derivados del mismo y fluroxipir, o los derivados del mismo
CL2008001048A1 (es) Compuestos derivados de heterociclos nitrogenados; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto como antibacterianos.

Legal Events

Date Code Title Description
FG Grant, registration