PE20010982A1 - Composicion estable para dosis oral de liberacion extendida - Google Patents
Composicion estable para dosis oral de liberacion extendidaInfo
- Publication number
- PE20010982A1 PE20010982A1 PE2000001371A PE0013712000A PE20010982A1 PE 20010982 A1 PE20010982 A1 PE 20010982A1 PE 2000001371 A PE2000001371 A PE 2000001371A PE 0013712000 A PE0013712000 A PE 0013712000A PE 20010982 A1 PE20010982 A1 PE 20010982A1
- Authority
- PE
- Peru
- Prior art keywords
- nucleum
- hours
- film
- plasma
- water
- Prior art date
Links
- 238000013265 extended release Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 abstract 3
- 229960001271 desloratadine Drugs 0.000 abstract 3
- 239000007888 film coating Substances 0.000 abstract 3
- 238000009501 film coating Methods 0.000 abstract 3
- 239000000314 lubricant Substances 0.000 abstract 3
- 239000002518 antifoaming agent Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000003607 modifier Substances 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 230000002249 decongestive effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 abstract 1
- 229960003908 pseudoephedrine Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Toys (AREA)
- Cosmetics (AREA)
Abstract
SE REFIERE A UNA COMPOSICION DE DOSIS ORAL SOLIDA DE LIBERACION EXTENDIDA REVESTIDA CON UNA PELICULA QUE COMPRENDE a)NUCLEO MATRIZ QUE COMPRENDE 1)DESCONGESTIVO COMO PSEUDOEFEDRINA PARA PRODUCIR UNA CONCENTRACION EN PLASMA MAXIMO GEOMETRICA DE 345 ng/ml A 365 ng/ml DE 7,60 HORAS A 8,40 HORAS; 2)MATRIZ POLIMERICA; 3)SAL BASICA INSOLUBLE EN AGUA (CALCIO, MAGNESIO, ALUMINIO), 4)AGLUTINANTE; 5)LUBRICANTE; 6)DESLIZANTE; b)UN SEGUNDO REVESTIMIENTO DE PELICULA QUE COMPRENDE: 1)DESLORATADINA PARA PRODUCIR UNA CONCENTRACION EN PLASMA MAXIMO GEOMETRICA DE 2,10ng/ml A 2,45ng/ml DE 4 HORAS A 4,5 HORAS Y PRODUCIR UNA CONCENTRACION EN PLASMA MAXIMO GEOMETRICA DE 3-HIDROXIDESLORATADINA DE 0,75 ng/ml EN 5,50 HORAS; 2)ESTER COPOLIMERICO NEUTRO O CATIONICO FORMADOR DE PELICULA QUE SE DILATA EN AGUA; 3)LUBRICANTE; 4)MODIFICADOR DE PELICULA SOLUBLE EN AGUA; 5)AGENTE ANTIESPUMA; c)PRIMER REVESTIMIENTO ENTRE EL REVESTIMIENTO DE PELICULA Y EL NUCLEO QUE PROVEE LA LIBERACION DE DESLORATADINA DESDE EL SEGUNDO REVESTIMIENTO DE PELICULA Y UNA LIBERACION EXTENDIDA DEL DESCONGESTIVO NASAL DESDE EL NUCLEO QUE COMPRENDE 1)ESTER COPOLIMERICO NEUTRO O CATIONICO FORMADOR DE PELICULA QUE SE DILATA EN AGUA; 2)LUBRICANTE; 3)MODIFICADOR DE PELICULA SOLUBLE EN AGUA; 4)AGENTE ANTIESPUMA; LA COMPOSICION SE CARACTERIZA POR CONTENER MENOS DE 2% DE PRODUCTOS DE DESCOMPOSICION DE DESLORATADINA COMO N-FORMILDESLORATADINA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17283699P | 1999-12-20 | 1999-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010982A1 true PE20010982A1 (es) | 2001-09-28 |
Family
ID=22629437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001371A PE20010982A1 (es) | 1999-12-20 | 2000-12-20 | Composicion estable para dosis oral de liberacion extendida |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US6979463B2 (es) |
| EP (2) | EP1112738B1 (es) |
| JP (3) | JP5042403B2 (es) |
| KR (2) | KR100936572B1 (es) |
| CN (3) | CN1679569A (es) |
| AR (1) | AR027033A1 (es) |
| AT (1) | ATE463240T1 (es) |
| AU (4) | AU2277101A (es) |
| BR (1) | BR0006403A (es) |
| CA (1) | CA2329217C (es) |
| CO (1) | CO5251435A1 (es) |
| CY (1) | CY1110693T1 (es) |
| CZ (1) | CZ302860B6 (es) |
| DE (1) | DE60044117D1 (es) |
| DK (1) | DK1112738T3 (es) |
| EC (1) | ECSP003836A (es) |
| EG (1) | EG23759A (es) |
| ES (1) | ES2341751T3 (es) |
| HK (1) | HK1034453A1 (es) |
| HU (1) | HUP0004988A3 (es) |
| ID (1) | ID28675A (es) |
| IL (1) | IL140450A (es) |
| MX (1) | MXPA00013037A (es) |
| MY (1) | MY130773A (es) |
| NO (1) | NO331645B1 (es) |
| NZ (1) | NZ509028A (es) |
| PE (1) | PE20010982A1 (es) |
| PL (1) | PL211573B1 (es) |
| PT (1) | PT1112738E (es) |
| RU (2) | RU2303440C2 (es) |
| SA (2) | SA01210741B1 (es) |
| SG (1) | SG109438A1 (es) |
| SI (1) | SI1112738T1 (es) |
| SK (1) | SK287684B6 (es) |
| TR (1) | TR200003787A2 (es) |
| TW (1) | TWI225414B (es) |
| WO (1) | WO2001045668A2 (es) |
| ZA (1) | ZA200007715B (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2276801A (en) | 1999-12-20 | 2001-07-03 | Schering Corporation | Extended release oral dosage composition |
| WO2001045668A2 (en) | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
| US7405223B2 (en) | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
| US20030070584A1 (en) | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
| JP2004534820A (ja) * | 2001-06-20 | 2004-11-18 | シェーリング コーポレイション | 鼻うっ血および鼻閉塞の処置のための抗ヒスタミン薬 |
| US8309118B2 (en) | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
| US8323692B2 (en) | 2002-02-21 | 2012-12-04 | Valeant International Bermuda | Controlled release dosage forms |
| US7780987B2 (en) | 2002-02-21 | 2010-08-24 | Biovail Laboratories International Srl | Controlled release dosage forms |
| WO2004108700A1 (en) * | 2003-03-12 | 2004-12-16 | Teva Gyogyszergyar Reszvenytarsasag | Processes for preparation of polymorphic forms of desloratadine |
| US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
| EP1700591A4 (en) * | 2003-12-01 | 2011-08-03 | Takeda Pharmaceutical | METHOD FOR THE TREATMENT OF A SOLID PHARMACEUTICAL PREPARATION BEFORE PRINTING AND PRESTIGIOUS SOLENOID PREPARATION TREATED BEFORE PRINTING |
| CA2585122A1 (en) * | 2004-10-25 | 2006-05-04 | Schering Corporation | M1 and/or m3 receptor antagonists in combination with other actives for treating respiratory disorders |
| US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
| US20060252831A1 (en) * | 2005-05-06 | 2006-11-09 | Christopher Offen | Method for the treatment of magnesium and potassium deficiencies |
| US20070014855A1 (en) * | 2005-07-12 | 2007-01-18 | Rahul Gawande S | Stable desloratadine compositions |
| US20070036859A1 (en) * | 2005-08-11 | 2007-02-15 | Perry Ronald L | Sustained release antihistamine and decongestant composition |
| US8068991B2 (en) | 2005-11-30 | 2011-11-29 | The Invention Science Fund I, Llc | Systems and methods for transmitting pathogen related information and responding |
| US8000981B2 (en) | 2005-11-30 | 2011-08-16 | The Invention Science Fund I, Llc | Methods and systems related to receiving nutraceutical associated information |
| US7974856B2 (en) | 2005-11-30 | 2011-07-05 | The Invention Science Fund I, Llc | Computational systems and methods related to nutraceuticals |
| US7827042B2 (en) | 2005-11-30 | 2010-11-02 | The Invention Science Fund I, Inc | Methods and systems related to transmission of nutraceutical associated information |
| US8297028B2 (en) | 2006-06-14 | 2012-10-30 | The Invention Science Fund I, Llc | Individualized pharmaceutical selection and packaging |
| US10296720B2 (en) | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
| US7927787B2 (en) | 2006-06-28 | 2011-04-19 | The Invention Science Fund I, Llc | Methods and systems for analysis of nutraceutical associated components |
| US8340944B2 (en) | 2005-11-30 | 2012-12-25 | The Invention Science Fund I, Llc | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
| FR2894143B1 (fr) | 2005-12-01 | 2008-05-02 | Pierre Fabre Medicament Sa | Composition a liberation prolongee de l'actif, son procede de preparation et son utilisation. |
| MX2008015358A (es) * | 2006-06-01 | 2009-03-06 | Schering Corp | Composiciones farmaceuticas para liberacion sostenida de fenilefrina. |
| EP2029105A1 (en) * | 2006-06-01 | 2009-03-04 | Schering Corporation | Phenylphrine pulsed release formulations and pharmaceutical compositions |
| NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
| PL2034970T3 (pl) * | 2006-06-01 | 2012-12-31 | Msd Consumer Care Inc | Preparat farmaceutyczny o przedłużonym uwalnianiu zawierający fenylefrynę |
| KR20090037930A (ko) * | 2006-07-11 | 2009-04-16 | 뮤추얼 파마슈티컬 컴퍼니 아이엔씨. | 조절 방출 제형 |
| CN101848706A (zh) * | 2007-06-01 | 2010-09-29 | 先灵-普劳健康护理产品公司 | 包含底物和含活性成分和聚乙烯醇的包衣的药用组合物 |
| PE20091084A1 (es) * | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
| US20120065221A1 (en) | 2009-02-26 | 2012-03-15 | Theraquest Biosciences, Inc. | Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use |
| WO2010143202A1 (en) * | 2009-06-09 | 2010-12-16 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical composition |
| TR201009396A2 (tr) | 2010-11-11 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Desloratadin granüller |
| DE102016107760B4 (de) * | 2016-04-26 | 2018-09-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Essbare Funktionsschichten und Überzüge auf Hybridpolymerbasis für Pharmazie und Lebensmittel |
| US20180187263A1 (en) | 2017-01-05 | 2018-07-05 | Iowa State University Research Foundation, Inc. | Kits for diagnostic detection and prevention of feedlot bovine respiratory disease |
| CR20230109A (es) | 2020-07-30 | 2023-05-11 | Faes Farma Sa | Sistema de liberación de fármacos descongestivos y bilastina |
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| US6423721B1 (en) * | 1998-09-10 | 2002-07-23 | Schering Corporation | Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines |
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| US6599913B1 (en) * | 2001-06-29 | 2003-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
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2000
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2001
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