NO332949B1 - Fremgangsmate for fremstilling av et in vitro peptidekspresjonsbibliotek av DNA-bundne peptider - Google Patents
Fremgangsmate for fremstilling av et in vitro peptidekspresjonsbibliotek av DNA-bundne peptiderInfo
- Publication number
- NO332949B1 NO332949B1 NO20051685A NO20051685A NO332949B1 NO 332949 B1 NO332949 B1 NO 332949B1 NO 20051685 A NO20051685 A NO 20051685A NO 20051685 A NO20051685 A NO 20051685A NO 332949 B1 NO332949 B1 NO 332949B1
- Authority
- NO
- Norway
- Prior art keywords
- dna
- peptide
- library
- protein
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220759A GB0220759D0 (en) | 2002-09-06 | 2002-09-06 | Display library |
| GB0304521A GB0304521D0 (en) | 2003-02-27 | 2003-02-27 | Display library |
| GB0304657A GB0304657D0 (en) | 2003-02-28 | 2003-02-28 | Display library |
| PCT/GB2003/003860 WO2004022746A1 (en) | 2002-09-06 | 2003-09-05 | In vitro peptide expression libraray |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20051685L NO20051685L (no) | 2005-06-06 |
| NO332949B1 true NO332949B1 (no) | 2013-02-04 |
Family
ID=31982028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20051685A NO332949B1 (no) | 2002-09-06 | 2005-04-05 | Fremgangsmate for fremstilling av et in vitro peptidekspresjonsbibliotek av DNA-bundne peptider |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7842476B2 (da) |
| EP (2) | EP1534830B1 (da) |
| JP (1) | JP4664677B2 (da) |
| KR (1) | KR101051245B1 (da) |
| CN (1) | CN100351375C (da) |
| AT (1) | ATE488586T1 (da) |
| AU (1) | AU2003260786B2 (da) |
| CA (1) | CA2497496C (da) |
| DE (1) | DE60335000D1 (da) |
| DK (1) | DK1534830T3 (da) |
| HK (1) | HK1072957A1 (da) |
| IL (1) | IL166903A (da) |
| NO (1) | NO332949B1 (da) |
| PT (1) | PT1534830E (da) |
| WO (1) | WO2004022746A1 (da) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0418651D0 (en) | 2004-08-20 | 2004-09-22 | Medical Res Council | Method |
| GB0505420D0 (en) * | 2005-03-16 | 2005-04-20 | Isogenica Ltd | Stable ligand selection method |
| GB0515115D0 (en) * | 2005-07-22 | 2005-08-31 | Isogenica Ltd | Peptide characterisation |
| GB0806562D0 (en) | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
| KR20110036638A (ko) | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
| ES2705714T3 (es) | 2008-10-31 | 2019-03-26 | Janssen Biotech Inc | Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones |
| ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
| GB201000352D0 (en) | 2010-01-11 | 2010-02-24 | Isogenica Ltd | Antimicrobial peptides |
| AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| ES2638311T3 (es) | 2010-04-27 | 2017-10-19 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, diagnósticas y de anticuerpos relacionadas con fragmentos de proteína de treonil ARNt sintetasas |
| CA2797271C (en) | 2010-04-28 | 2021-05-25 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
| US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
| WO2011150279A2 (en) | 2010-05-27 | 2011-12-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
| US9034320B2 (en) | 2010-04-29 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases |
| EP2571531B1 (en) | 2010-04-30 | 2016-06-22 | Janssen Biotech, Inc. | Stabilized fibronectin domain compositions, methods and uses |
| JP5976638B2 (ja) | 2010-05-03 | 2016-08-23 | エータイアー ファーマ， インコーポレイテッド | アルギニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| AU2011248357B2 (en) | 2010-05-03 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
| JP6008840B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | フェニルアラニルαｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP6008841B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ， インコーポレイテッド | メチオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| EP2566492B1 (en) | 2010-05-04 | 2016-10-26 | aTyr Pharma, Inc. | Innovative discovery of therapeutic compositions related to protein fragments of glutamyl-prolyl-trna synthetases |
| EP2566499B1 (en) | 2010-05-04 | 2017-01-25 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
| EP2568996B1 (en) | 2010-05-14 | 2017-10-04 | aTyr Pharma, Inc. | Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| WO2011146410A2 (en) | 2010-05-17 | 2011-11-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
| CN103118694B (zh) | 2010-06-01 | 2016-08-03 | Atyr医药公司 | 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| KR102099730B1 (ko) | 2010-07-12 | 2020-04-16 | 에이티와이알 파마, 인코포레이티드 | 아스파르틸trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| WO2012021247A2 (en) | 2010-07-12 | 2012-02-16 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| US20130202576A1 (en) | 2010-07-12 | 2013-08-08 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| GB201013284D0 (en) | 2010-08-06 | 2010-09-22 | Isogenica Ltd | Scaffold peptides |
| AU2011293294B2 (en) | 2010-08-25 | 2016-03-24 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases |
| WO2012048125A2 (en) | 2010-10-06 | 2012-04-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| US9753040B2 (en) | 2010-12-01 | 2017-09-05 | Mitsubishi Tanabe Pharma Corporation | Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing and screening fab using same |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| KR102142385B1 (ko) | 2011-09-27 | 2020-08-10 | 얀센 바이오테크 인코포레이티드 | 대체 결합 표면을 가진 피브로넥틴 유형 iii 반복체 기반의 단백질 스캐폴드 |
| US20130090265A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices |
| US20130090266A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for optimization of peptide screening |
| US20130090247A1 (en) | 2011-10-11 | 2013-04-11 | Biolauncher Ltd. | Methods and systems for identification of binding pharmacophores |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| EP2797959A4 (en) | 2011-12-29 | 2015-08-26 | Atyr Pharma Inc | ASPARTYL-tRNA synthetase FC CONJUGATES |
| GB2500243A (en) * | 2012-03-15 | 2013-09-18 | Isogenica Ltd | Identifying members of immobilised peptide libraries comprising protein-DNA complexes |
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| CN104955838B (zh) | 2012-11-21 | 2021-02-02 | 詹森生物科技公司 | 双特异性EGFR/c-Met抗体 |
| JP6397479B2 (ja) | 2013-03-15 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート |
| EA035745B1 (ru) | 2013-10-14 | 2020-08-05 | Янссен Байотек, Инк. | Связующие молекулы на основе домена фибронектина типа iii с внедренными остатками цистеина |
| WO2016134521A1 (en) | 2015-02-27 | 2016-09-01 | The University Of Hong Kong | Dna display and methods thereof |
| BR112017021308A2 (pt) | 2015-04-06 | 2018-09-25 | Subdomain, Llc | polipeptídeos contendo domínio de ligação de forma e uso dos mesmos |
| JP7366518B2 (ja) | 2015-05-06 | 2023-10-23 | ヤンセン バイオテツク，インコーポレーテツド | 前立腺特異的膜抗原結合フィブロネクチンｉｉｉ型ドメイン |
| JP7111627B2 (ja) | 2016-06-03 | 2022-08-02 | ヤンセン バイオテツク，インコーポレーテツド | 血清アルブミン結合フィブロネクチンｉｉｉ型ドメイン |
| EA201990067A1 (ru) | 2016-06-21 | 2019-07-31 | Янссен Байотек, Инк. | Цистеин-модифицированные связывающие молекулы на основе домена фибронектина iii типа |
| EP3512541A1 (en) | 2016-09-14 | 2019-07-24 | Janssen Biotech, Inc. | Chimeric antigen receptors comprising bcma-specific fibronectin type iii domains and uses thereof |
| EP3554535A4 (en) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS |
| RU2759952C2 (ru) | 2016-12-14 | 2021-11-19 | Янссен Байотек, Инк. | Cd8a-связывающие домены типа iii фибронектина |
| EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| EP3600394A4 (en) | 2017-03-22 | 2021-04-14 | Research Corporation Technologies, Inc. | MANIPULATED STABLE CH2-POLYPEPTIDES |
| CA3060514A1 (en) | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| JP7250766B2 (ja) | 2017-08-25 | 2023-04-03 | ヤンセン バイオテツク，インコーポレーテツド | ＦＣγＲＩＩ結合フィブロネクチンＩＩＩ型ドメイン、それらのコンジュゲート、及びそれらを含む多重特異性分子 |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| EP4045061A4 (en) | 2019-10-14 | 2024-04-17 | ARO Biotherapeutics Company | FIBRONECTIN TYPE III DOMAINS BINDING TO CD137 |
| KR20240031947A (ko) | 2021-04-14 | 2024-03-08 | 에이알오 바이오테라퓨틱스 컴패니 | Fn3 도메인-시르나 접합체 및 이의 용도 |
| MX2023012128A (es) | 2021-04-14 | 2024-01-11 | Aro Biotherapeutics Company | Dominios tipo iii de la fibronectina que se unen a cd71. |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2118066T3 (es) | 1989-10-05 | 1998-09-16 | Optein Inc | Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos. |
| DE69225227T2 (de) * | 1991-06-27 | 1998-10-29 | Genelabs Tech Inc | Screeningtest für den nachweis von dna-bindenden molekülen |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| GB9703369D0 (en) * | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| DK0985032T4 (da) * | 1997-05-28 | 2009-08-31 | Crescendo Biolog Ltd | Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner |
| EP1801214B1 (en) | 1997-07-07 | 2010-11-10 | Medical Research Council | In vitro sorting method |
| GB9718455D0 (en) * | 1997-09-02 | 1997-11-05 | Mcgregor Duncan P | Chimeric binding peptide library screening method |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| AU4499499A (en) | 1999-04-01 | 2000-10-23 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| EP1350846A4 (en) | 2000-12-07 | 2005-01-26 | Univ Keio | C-TERMINAL MODIFIED PROTEIN AND METHOD FOR THE PRODUCTION THEREOF, IN THE PREPARATION OF C-TERMINAL MODIFIED PROTEIN TO BE USED, AND TRANSLATION TEMPLATE AND METHOD FOR DETECTING PROTEIN CHANGING EFFECT USING THE C-TERMINAL MODIFIED PROTEIN |
| JP4963142B2 (ja) | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
| JP3706942B2 (ja) | 2001-08-07 | 2005-10-19 | 学校法人慶應義塾 | 物質と蛋白質との間の相互作用の検出方法、物質と相互作用する蛋白質のスクリーニング方法、及び、物質とその物質と相互作用する蛋白質との複合体の形成方法 |
| US20060156511A1 (en) * | 2005-01-19 | 2006-07-20 | Li Yuan J | Caster |
-
2003
- 2003-09-05 AU AU2003260786A patent/AU2003260786B2/en not_active Ceased
- 2003-09-05 KR KR1020057003832A patent/KR101051245B1/ko active IP Right Grant
- 2003-09-05 PT PT03793896T patent/PT1534830E/pt unknown
- 2003-09-05 CN CNB038211343A patent/CN100351375C/zh not_active Expired - Lifetime
- 2003-09-05 EP EP03793896A patent/EP1534830B1/en not_active Expired - Lifetime
- 2003-09-05 EP EP10010747A patent/EP2385118A1/en not_active Withdrawn
- 2003-09-05 AT AT03793896T patent/ATE488586T1/de active
- 2003-09-05 DE DE60335000T patent/DE60335000D1/de not_active Expired - Lifetime
- 2003-09-05 CA CA2497496A patent/CA2497496C/en not_active Expired - Fee Related
- 2003-09-05 DK DK03793896.6T patent/DK1534830T3/da active
- 2003-09-05 JP JP2004533653A patent/JP4664677B2/ja not_active Expired - Fee Related
- 2003-09-05 WO PCT/GB2003/003860 patent/WO2004022746A1/en active Application Filing
- 2003-09-05 US US10/526,479 patent/US7842476B2/en not_active Expired - Lifetime
-
2005
- 2005-02-15 IL IL166903A patent/IL166903A/en active IP Right Grant
- 2005-04-05 NO NO20051685A patent/NO332949B1/no not_active IP Right Cessation
- 2005-06-07 HK HK05104771.2A patent/HK1072957A1/xx not_active IP Right Cessation
-
2010
- 2010-10-21 US US12/909,420 patent/US8679781B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US7842476B2 (en) | 2010-11-30 |
| CA2497496A1 (en) | 2004-03-18 |
| WO2004022746A1 (en) | 2004-03-18 |
| JP2005537795A (ja) | 2005-12-15 |
| NO20051685L (no) | 2005-06-06 |
| DK1534830T3 (da) | 2011-02-14 |
| EP1534830B1 (en) | 2010-11-17 |
| AU2003260786A1 (en) | 2004-03-29 |
| CA2497496C (en) | 2012-05-15 |
| EP1534830A1 (en) | 2005-06-01 |
| PT1534830E (pt) | 2011-01-31 |
| KR20050057216A (ko) | 2005-06-16 |
| US20120149591A1 (en) | 2012-06-14 |
| KR101051245B1 (ko) | 2011-07-21 |
| CN1681924A (zh) | 2005-10-12 |
| EP2385118A1 (en) | 2011-11-09 |
| IL166903A (en) | 2012-06-28 |
| US20060035232A1 (en) | 2006-02-16 |
| CN100351375C (zh) | 2007-11-28 |
| JP4664677B2 (ja) | 2011-04-06 |
| DE60335000D1 (de) | 2010-12-30 |
| US8679781B2 (en) | 2014-03-25 |
| AU2003260786B2 (en) | 2008-03-13 |
| ATE488586T1 (de) | 2010-12-15 |
| HK1072957A1 (en) | 2005-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |