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DK1534830T3 - In vito-peptid-ekspressionsbibliotek - Google Patents

In vito-peptid-ekspressionsbibliotek

Info

Publication number
DK1534830T3
DK1534830T3 DK03793896.6T DK03793896T DK1534830T3 DK 1534830 T3 DK1534830 T3 DK 1534830T3 DK 03793896 T DK03793896 T DK 03793896T DK 1534830 T3 DK1534830 T3 DK 1534830T3
Authority
DK
Denmark
Prior art keywords
library
vito
peptide expression
expression library
making
Prior art date
Application number
DK03793896.6T
Other languages
English (en)
Inventor
Duncan Mcgregor
Richard Odegrip
Kevin Fitzgerald
Rosemarie Hederer
Bill Eldridge
Chris Ullman
Philip Kuhlman
David Coomber
Original Assignee
Isogenica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0220759A external-priority patent/GB0220759D0/en
Priority claimed from GB0304521A external-priority patent/GB0304521D0/en
Priority claimed from GB0304657A external-priority patent/GB0304657D0/en
Application filed by Isogenica Ltd filed Critical Isogenica Ltd
Application granted granted Critical
Publication of DK1534830T3 publication Critical patent/DK1534830T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK03793896.6T 2002-09-06 2003-09-05 In vito-peptid-ekspressionsbibliotek DK1534830T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0220759A GB0220759D0 (en) 2002-09-06 2002-09-06 Display library
GB0304521A GB0304521D0 (en) 2003-02-27 2003-02-27 Display library
GB0304657A GB0304657D0 (en) 2003-02-28 2003-02-28 Display library
PCT/GB2003/003860 WO2004022746A1 (en) 2002-09-06 2003-09-05 In vitro peptide expression libraray

Publications (1)

Publication Number Publication Date
DK1534830T3 true DK1534830T3 (da) 2011-02-14

Family

ID=31982028

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03793896.6T DK1534830T3 (da) 2002-09-06 2003-09-05 In vito-peptid-ekspressionsbibliotek

Country Status (15)

Country Link
US (2) US7842476B2 (da)
EP (2) EP2385118A1 (da)
JP (1) JP4664677B2 (da)
KR (1) KR101051245B1 (da)
CN (1) CN100351375C (da)
AT (1) ATE488586T1 (da)
AU (1) AU2003260786B2 (da)
CA (1) CA2497496C (da)
DE (1) DE60335000D1 (da)
DK (1) DK1534830T3 (da)
HK (1) HK1072957A1 (da)
IL (1) IL166903A (da)
NO (1) NO332949B1 (da)
PT (1) PT1534830E (da)
WO (1) WO2004022746A1 (da)

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AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
ES2638311T3 (es) 2010-04-27 2017-10-19 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, diagnósticas y de anticuerpos relacionadas con fragmentos de proteína de treonil ARNt sintetasas
CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
EP2563911B1 (en) 2010-04-28 2021-07-21 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
WO2011139907A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
DK3103478T3 (da) 2010-04-30 2019-05-13 Janssen Biotech Inc Stabiliserede fibronektin-domænesammensætninger, fremgangsmåder og anvendelser
AU2011248355B2 (en) 2010-05-03 2017-01-19 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Arginyl-tRNA synthetases
CA2797799C (en) 2010-05-03 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
JP6008840B2 (ja) 2010-05-03 2016-10-19 エータイアー ファーマ， インコーポレイテッド フェニルアラニルαｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2566496B1 (en) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
AU2011248100B2 (en) 2010-05-04 2017-01-19 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
EP2575856B1 (en) 2010-05-27 2017-08-16 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
JP5906237B2 (ja) 2010-06-01 2016-04-20 エータイアー ファーマ， インコーポレイテッド リジルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103118695B (zh) 2010-07-12 2016-08-03 Atyr医药公司 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
CA2804278C (en) 2010-07-12 2021-07-13 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
AU2011289833C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Histidyl-tRNA synthetases
GB201013284D0 (en) 2010-08-06 2010-09-22 Isogenica Ltd Scaffold peptides
CA2808539C (en) 2010-08-25 2021-05-25 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases
CA2812795C (en) 2010-10-06 2021-08-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
US9753040B2 (en) 2010-12-01 2017-09-05 Mitsubishi Tanabe Pharma Corporation Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing and screening fab using same
WO2013022982A2 (en) 2011-08-09 2013-02-14 Atyr Pharma, Inc. Pegylated tyrosyl-trna synthetase polypeptides
BR112014007469B1 (pt) 2011-09-27 2022-06-14 Janssen Biotech, Inc Método de fabricação de uma biblioteca de domínios de módulo de fibronectina tipo iii (fn3), biblioteca e método para obter um arcabouço de proteína
US20130090265A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices
US20130090266A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Methods and systems for optimization of peptide screening
US20130090247A1 (en) 2011-10-11 2013-04-11 Biolauncher Ltd. Methods and systems for identification of binding pharmacophores
US9816084B2 (en) 2011-12-06 2017-11-14 Atyr Pharma, Inc. Aspartyl-tRNA synthetases
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US9688978B2 (en) 2011-12-29 2017-06-27 Atyr Pharma, Inc. Aspartyl-tRNA synthetase-Fc conjugates
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US9695228B2 (en) 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
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CA2926262A1 (en) 2013-10-14 2015-04-23 Janssen Biotech, Inc. Cysteine engineered fibronectin type iii domain binding molecules
WO2016134521A1 (en) 2015-02-27 2016-09-01 The University Of Hong Kong Dna display and methods thereof
ES2866202T3 (es) 2015-04-06 2021-10-19 Subdomain Llc Polipéptidos que contienen dominios de unión de novo y usos de los mismos
US10844111B2 (en) 2015-05-06 2020-11-24 Janssen Biotech, Inc. Prostate specific membrane antigen binding fibronectin type III domains
MA45186A (fr) * 2016-06-03 2019-04-10 Janssen Biotech Inc Domaines de fibronectine de type iii se liant à l'albumine sérique
MA45412A (fr) 2016-06-21 2021-05-26 Janssen Biotech Inc Molécules de liaison au domaine de fibronectine de type iii modifiées par la cystéine
CA3036972A1 (en) 2016-09-14 2018-03-22 Janssen Biotech, Inc. Chimeric antigen receptors comprising bcma-specific fibronectin type iii domains and uses thereof
AU2017378226A1 (en) 2016-12-14 2019-06-20 Janssen Biotech, Inc. CD8A-binding fibronectin type III domains
WO2018111976A1 (en) 2016-12-14 2018-06-21 Janssen Biotech, Inc. Pd-l1 binding fibronectin type iii domains
US10611823B2 (en) 2016-12-14 2020-04-07 Hanssen Biotech, Inc CD137 binding fibronectin type III domains
AU2018240029A1 (en) 2017-03-22 2019-10-17 Research Corporation Technologies, Inc. Engineered stable CH2 polypeptides
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Also Published As

Publication number Publication date
CN1681924A (zh) 2005-10-12
JP2005537795A (ja) 2005-12-15
AU2003260786A1 (en) 2004-03-29
AU2003260786B2 (en) 2008-03-13
PT1534830E (pt) 2011-01-31
KR101051245B1 (ko) 2011-07-21
KR20050057216A (ko) 2005-06-16
EP2385118A1 (en) 2011-11-09
WO2004022746A1 (en) 2004-03-18
NO332949B1 (no) 2013-02-04
DE60335000D1 (de) 2010-12-30
IL166903A (en) 2012-06-28
HK1072957A1 (en) 2005-09-16
CA2497496C (en) 2012-05-15
NO20051685L (no) 2005-06-06
EP1534830A1 (en) 2005-06-01
JP4664677B2 (ja) 2011-04-06
US7842476B2 (en) 2010-11-30
EP1534830B1 (en) 2010-11-17
CN100351375C (zh) 2007-11-28
CA2497496A1 (en) 2004-03-18
US20120149591A1 (en) 2012-06-14
US8679781B2 (en) 2014-03-25
ATE488586T1 (de) 2010-12-15
US20060035232A1 (en) 2006-02-16

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