NO310804B1 - Stabilisert injiserbar formulering av humant veksthormon og fremgangsmåte for fremstilling derav - Google Patents

Stabilisert injiserbar formulering av humant veksthormon og fremgangsmåte for fremstilling derav Download PDF

Info

Publication number: NO310804B1
Authority: NO; Norway
Prior art keywords: formulation; growth hormone; hgh; citrate; buffer substance
Prior art date: 1992-04-03

Application number

NO19934355A

Other languages

English (en)

Norwegian (no)

Other versions

NO934355D0 (no

NO934355L (no

Inventor

Staffan Castensson

Ebba Florin-Robertsson

Elvy Hoekby

Sirkka Thome

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-03

Filing date

1993-11-30

Publication date

2001-09-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20385860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO310804(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-11-30 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

1993-11-30 Publication of NO934355D0 publication Critical patent/NO934355D0/no

1993-12-01 Publication of NO934355L publication Critical patent/NO934355L/no

2001-09-03 Publication of NO310804B1 publication Critical patent/NO310804B1/no

Links

239000000203 mixture Substances 0.000 title claims abstract description 32
238000009472 formulation Methods 0.000 title claims abstract description 31
108010000521 Human Growth Hormone Proteins 0.000 title claims description 35
102000002265 Human Growth Hormone Human genes 0.000 title claims description 35
239000000854 Human Growth Hormone Substances 0.000 title claims description 35
238000000034 method Methods 0.000 title abstract description 11
238000002360 preparation method Methods 0.000 title abstract description 10
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims abstract description 36
102000018997 Growth Hormone Human genes 0.000 claims abstract description 30
108010051696 Growth Hormone Proteins 0.000 claims abstract description 30
239000000122 growth hormone Substances 0.000 claims abstract description 30
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 15
239000012928 buffer substance Substances 0.000 claims abstract description 15
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 13
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 12
235000019445 benzyl alcohol Nutrition 0.000 claims abstract description 12
239000007864 aqueous solution Substances 0.000 claims abstract description 10
239000003755 preservative agent Substances 0.000 claims abstract description 8
230000002335 preservative effect Effects 0.000 claims abstract description 8
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 7
229930195725 Mannitol Natural products 0.000 claims abstract description 7
239000000594 mannitol Substances 0.000 claims abstract description 7
235000010355 mannitol Nutrition 0.000 claims abstract description 7
239000004471 Glycine Substances 0.000 claims abstract description 6
150000001413 amino acids Chemical class 0.000 claims abstract description 6
235000014633 carbohydrates Nutrition 0.000 claims abstract description 4
150000001720 carbohydrates Chemical class 0.000 claims abstract description 4
239000013020 final formulation Substances 0.000 claims abstract description 4
239000007972 injectable composition Substances 0.000 claims abstract description 4
238000000746 purification Methods 0.000 claims abstract description 4
150000005846 sugar alcohols Chemical class 0.000 claims abstract description 4
239000001509 sodium citrate Substances 0.000 claims description 8
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 3
235000001014 amino acid Nutrition 0.000 abstract description 5
230000008569 process Effects 0.000 abstract description 4
239000003102 growth factor Substances 0.000 abstract description 3
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract description 2
235000004279 alanine Nutrition 0.000 abstract description 2
239000000470 constituent Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 description 24
235000018102 proteins Nutrition 0.000 description 22
102000004169 proteins and genes Human genes 0.000 description 22
239000000243 solution Substances 0.000 description 18
239000000047 product Substances 0.000 description 16
238000004220 aggregation Methods 0.000 description 8
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239000000872 buffer Substances 0.000 description 8
230000006240 deamidation Effects 0.000 description 7
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229910019142 PO4 Inorganic materials 0.000 description 5
239000010452 phosphate Substances 0.000 description 5
241001465754 Metazoa Species 0.000 description 4
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
239000012537 formulation buffer Substances 0.000 description 4
238000001155 isoelectric focusing Methods 0.000 description 4
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229920001184 polypeptide Polymers 0.000 description 4
102000004196 processed proteins & peptides Human genes 0.000 description 4
108090000765 processed proteins & peptides Proteins 0.000 description 4
238000003860 storage Methods 0.000 description 4
238000009826 distribution Methods 0.000 description 3
229940063135 genotropin Drugs 0.000 description 3
238000000926 separation method Methods 0.000 description 3
239000011734 sodium Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
229920002684 Sepharose Polymers 0.000 description 2
239000000654 additive Substances 0.000 description 2
108010006025 bovine growth hormone Proteins 0.000 description 2
230000006652 catabolic pathway Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
238000001035 drying Methods 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
239000000499 gel Substances 0.000 description 2
230000003647 oxidation Effects 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
210000001322 periplasm Anatomy 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
AOFUBOWZWQFQJU-SNOJBQEQSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol;(2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O AOFUBOWZWQFQJU-SNOJBQEQSA-N 0.000 description 1
QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 1
208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
206010013883 Dwarfism Diseases 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
241000282412 Homo Species 0.000 description 1
101000664737 Homo sapiens Somatotropin Proteins 0.000 description 1
102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
102000013275 Somatomedins Human genes 0.000 description 1
208000026928 Turner syndrome Diseases 0.000 description 1
238000007112 amidation reaction Methods 0.000 description 1
238000012870 ammonium sulfate precipitation Methods 0.000 description 1
239000000959 ampholyte mixture Substances 0.000 description 1
239000003708 ampul Substances 0.000 description 1
239000013011 aqueous formulation Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
229940075397 calomel Drugs 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000007979 citrate buffer Substances 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000011188 deamidation reaction Methods 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
238000011067 equilibration Methods 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
239000013613 expression plasmid Substances 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000011049 filling Methods 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
239000012678 infectious agent Substances 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000012931 lyophilized formulation Substances 0.000 description 1
239000008176 lyophilized powder Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000006011 modification reaction Methods 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
230000010494 opalescence Effects 0.000 description 1
239000003186 pharmaceutical solution Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
208000003068 pituitary dwarfism Diseases 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
210000002826 placenta Anatomy 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000002904 solvent Substances 0.000 description 1
229960004532 somatropin Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
239000012905 visible particle Substances 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

NO19934355A 1992-04-03 1993-11-30 Stabilisert injiserbar formulering av humant veksthormon og fremgangsmåte for fremstilling derav NO310804B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9201073A SE9201073D0 (sv)	1992-04-03	1992-04-03	Protein formulation
PCT/SE1993/000281 WO1993019776A1 (en)	1992-04-03	1993-04-01	Protein formulation comprising growth hormone

Publications (3)

Publication Number	Publication Date
NO934355D0 NO934355D0 (no)	1993-11-30
NO934355L NO934355L (no)	1993-12-01
NO310804B1 true NO310804B1 (no)	2001-09-03

Family

ID=20385860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19934355A NO310804B1 (no)	1992-04-03	1993-11-30	Stabilisert injiserbar formulering av humant veksthormon og fremgangsmåte for fremstilling derav

Country Status (15)

Country	Link
US (1)	US5567677A (de)
EP (1)	EP0587858B2 (de)
JP (1)	JP3268557B2 (de)
AT (1)	ATE196092T1 (de)
AU (1)	AU666007B2 (de)
CA (1)	CA2102693C (de)
DE (1)	DE69329367T3 (de)
DK (1)	DK0587858T3 (de)
ES (1)	ES2150940T5 (de)
GR (1)	GR3034925T3 (de)
NO (1)	NO310804B1 (de)
NZ (1)	NZ251498A (de)
PT (1)	PT587858E (de)
SE (1)	SE9201073D0 (de)
WO (1)	WO1993019776A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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US5981485A (en) *	1997-07-14	1999-11-09	Genentech, Inc.	Human growth hormone aqueous formulation
US5763394A (en) *	1988-04-15	1998-06-09	Genentech, Inc.	Human growth hormone aqueous formulation
US5849704A (en) *	1991-12-20	1998-12-15	Novo Nordisk A/S	Pharmaceutical formulation
US6022858A (en) *	1991-12-20	2000-02-08	Novo Nordisk A/S	Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
US5849700A (en) *	1991-12-20	1998-12-15	Novo Nordisk A/S	Pharmaceutical formulation
DK204791D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Hidtil ukendt farmaceutisk praeparat
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2719479B1 (fr) *	1994-05-04	1996-07-26	Sanofi Elf	Formulation stable lyophilisée comprenant une protéine: kit de dosage.
US5631225A (en) *	1994-10-13	1997-05-20	Novo Nordisk A/S	Pharmaceutical formulation
IL115592A (en) *	1994-10-13	2000-07-26	Novo Nordisk As	Stabilized pharmaceutical formulation comprising a growth hormone and leucine
US5654278A (en) *	1994-10-13	1997-08-05	Novo Nordisk A/S	Composition and method comprising growth hormone and leucine
US5547696A (en) *	1994-10-13	1996-08-20	Novo Nordisk A/S	Pharmaceutical formulation
US5705482A (en) *	1995-01-13	1998-01-06	Novo Nordisk A/S	Pharmaceutical formulation
US5552385A (en) *	1995-06-05	1996-09-03	Novo Nordisk A/S	Pharmaceutical formulation
DE19539574A1 (de)	1995-10-25	1997-04-30	Boehringer Mannheim Gmbh	Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
GB9526733D0 (en) *	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
AUPN801296A0 (en)	1996-02-12	1996-03-07	Csl Limited	Stabilised growth hormone formulation and method of preparation thereof
US20070179096A1 (en)	1996-04-24	2007-08-02	Novo Nordisk A/S	Pharmaceutical Formulation
ZA9711733B (en) *	1996-12-31	1998-07-01	Monsanto Co	Method for solubilization and naturation of somatotropins
ZA9711731B (en)	1996-12-31	1998-07-01	Monsanto Co	Aqueous glycerol formulations of somatotropin
JP3723857B2 (ja) *	1998-02-04	2005-12-07	日本ケミカルリサーチ株式会社	ヒト成長ホルモン含有水性医薬組成物
US6979442B1 (en)	1998-08-17	2005-12-27	Pfizer Inc.	Stabilized protein compositions
IL147253A0 (en) *	1999-07-12	2002-08-14	Grandis Biotech Gmbh	Growth hormone formulations
WO2002011695A2 (en)	2000-08-07	2002-02-14	Inhale Therapeutic Systems, Inc.	Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
GB2371227A (en) *	2001-01-10	2002-07-24	Grandis Biotech Gmbh	Crystallisation - resistant aqueous growth hormone formulations
AU2002342653A1 (en)	2001-05-14	2002-11-25	The Gouvernment Of The United States Of America, Represented By The Secretary, Department Of Health	Modified growth hormone
EP1463752A4 (de)	2001-12-21	2005-07-13	Human Genome Sciences Inc	Albuminfusionsproteine
EP1485116A4 (de) *	2002-02-27	2006-06-07	Univ Wake Forest	Angiotensin-(1-7)- und angiotensin-(1-7)-agonisten zur hemmung des krebszellenwachstums
US20070065469A1 (en) *	2002-07-09	2007-03-22	Michael Betz	Liquid formulations with high concentration of human growth hormone (high) comprising glycine
AR040527A1 (es) *	2002-07-09	2005-04-13	Grandis Biotech Gmbh	Formulaciones de hgh en alta concentracion que contienen glicina
US20060252682A1 (en) *	2003-03-18	2006-11-09	Ares Trading S.A.	Liquid growth hormone formulation and process of preparation thereof
JP4845741B2 (ja)	2003-12-23	2011-12-28	ファルマシアコーポレーション	安定な成長ホルモン液体製剤
CN100574801C (zh) *	2004-04-07	2009-12-30	阿雷斯贸易股份有限公司	液体生长激素制剂
CA2570324C (en) *	2004-08-03	2014-07-22	Transtech Pharma, Inc.	Rage fusion proteins and methods of use
MX2007001556A (es) *	2004-08-03	2008-03-05	Transtech Pharma Inc	Proteinas de fusion del receptor para los productos finales glucados avanzados y metodos de uso.
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1992
- 1992-04-03 SE SE9201073A patent/SE9201073D0/xx unknown
1993
- 1993-04-01 DE DE69329367T patent/DE69329367T3/de not_active Expired - Fee Related
- 1993-04-01 PT PT93908252T patent/PT587858E/pt unknown
- 1993-04-01 AT AT93908252T patent/ATE196092T1/de not_active IP Right Cessation
- 1993-04-01 US US08/162,017 patent/US5567677A/en not_active Expired - Lifetime
- 1993-04-01 ES ES93908252T patent/ES2150940T5/es not_active Expired - Lifetime
- 1993-04-01 AU AU39135/93A patent/AU666007B2/en not_active Ceased
- 1993-04-01 DK DK93908252T patent/DK0587858T3/da active
- 1993-04-01 EP EP93908252A patent/EP0587858B2/de not_active Expired - Lifetime
- 1993-04-01 CA CA002102693A patent/CA2102693C/en not_active Expired - Lifetime
- 1993-04-01 NZ NZ251498A patent/NZ251498A/en not_active IP Right Cessation
- 1993-04-01 JP JP51737893A patent/JP3268557B2/ja not_active Expired - Lifetime
- 1993-04-01 WO PCT/SE1993/000281 patent/WO1993019776A1/en active IP Right Grant
- 1993-11-30 NO NO19934355A patent/NO310804B1/no unknown
2000
- 2000-11-28 GR GR20000402632T patent/GR3034925T3/el unknown

Also Published As

Publication number	Publication date
NO934355D0 (no)	1993-11-30
EP0587858B1 (de)	2000-09-06
NO934355L (no)	1993-12-01
DE69329367D1 (de)	2000-10-12
JPH06508156A (ja)	1994-09-14
CA2102693C (en)	2008-06-17
NZ251498A (en)	1995-07-26
JP3268557B2 (ja)	2002-03-25
PT587858E (pt)	2001-02-28
SE9201073D0 (sv)	1992-04-03
WO1993019776A1 (en)	1993-10-14
AU666007B2 (en)	1996-01-25
ES2150940T3 (es)	2000-12-16
DE69329367T3 (de)	2008-06-19
DE69329367T2 (de)	2001-06-21
DK0587858T3 (da)	2000-12-18
AU3913593A (en)	1993-11-08
ATE196092T1 (de)	2000-09-15
ES2150940T5 (es)	2008-04-16
EP0587858A1 (de)	1994-03-23
EP0587858B2 (de)	2007-11-14
CA2102693A1 (en)	1993-10-04
US5567677A (en)	1996-10-22
GR3034925T3 (en)	2001-02-28

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RU2214285C2 (ru)	2003-10-20	Композиция для использования в однодозовом шприце
CA2516314C (en)	2012-01-03	Liquid growth hormone formulation and process of preparation thereof
Skottner et al.	1988	Biological characterization of charge isomers of human growth hormone
CA2226553A1 (en)	1997-01-30	A stabilized pharmaceutical formulation comprising a growth hormone and a peptide comprising at least, one basic amino acid residue and at least one acid amino acid residue
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AU2004222528B2 (en)	2010-02-11	Stabilisation of growth hormones in solution
MXPA03008545A (es)	2005-03-28	Composiciones farmaceuticas que contienen la hormona humana del crecimiento.