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NO20023516D0 - Antibakterielle 3-aminokinazolinon-2,4-dioner - Google Patents

Antibakterielle 3-aminokinazolinon-2,4-dioner

Info

Publication number
NO20023516D0
NO20023516D0 NO20023516A NO20023516A NO20023516D0 NO 20023516 D0 NO20023516 D0 NO 20023516D0 NO 20023516 A NO20023516 A NO 20023516A NO 20023516 A NO20023516 A NO 20023516A NO 20023516 D0 NO20023516 D0 NO 20023516D0
Authority
NO
Norway
Prior art keywords
aminoquinazolinone
dione
antibacterial
Prior art date
Application number
NO20023516A
Other languages
English (en)
Other versions
NO20023516L (no
Inventor
Paul Bird
Edmund Lee Ellsworth
Dai Quoc Nguyen
Joseph Peter Sanchez
Howard Daniel Hollis Showalter
Rajeshwar Singh
Michael Andrew Stier
Tuan Phong Tran
Brian Morgan Watson
Judy Yip
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO20023516L publication Critical patent/NO20023516L/no
Publication of NO20023516D0 publication Critical patent/NO20023516D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
NO20023516A 2000-01-24 2002-07-23 Antibakterielle 3-aminokinazolinon-2,4-dioner NO20023516D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18
PCT/US2000/033656 WO2001053273A1 (en) 2000-01-24 2000-12-12 3-aminoquinazolin-2,4-dione antibacterial agents

Publications (2)

Publication Number Publication Date
NO20023516L NO20023516L (no) 2002-07-23
NO20023516D0 true NO20023516D0 (no) 2002-07-23

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023516A NO20023516D0 (no) 2000-01-24 2002-07-23 Antibakterielle 3-aminokinazolinon-2,4-dioner

Country Status (38)

Country Link
US (2) US7094780B1 (no)
EP (1) EP1255739B1 (no)
JP (1) JP4811978B2 (no)
KR (1) KR20020067701A (no)
CN (1) CN1425008A (no)
AP (1) AP2002002603A0 (no)
AR (1) AR030186A1 (no)
AT (1) ATE398110T1 (no)
AU (1) AU783078B2 (no)
BG (1) BG107023A (no)
BR (1) BR0017010A (no)
CA (1) CA2393802C (no)
CO (1) CO5320600A1 (no)
CR (1) CR6709A (no)
DE (1) DE60039194D1 (no)
EA (1) EA005585B1 (no)
EE (1) EE200200412A (no)
ES (1) ES2304992T3 (no)
GE (1) GEP20053429B (no)
HK (1) HK1054237A1 (no)
HN (1) HN2001000009A (no)
HR (1) HRP20020696A2 (no)
HU (1) HUP0204101A3 (no)
IL (1) IL150393A0 (no)
IS (1) IS6448A (no)
MA (1) MA26866A1 (no)
MX (1) MXPA02005989A (no)
NO (1) NO20023516D0 (no)
OA (1) OA12316A (no)
PA (1) PA8510101A1 (no)
PE (1) PE20011060A1 (no)
PL (1) PL356837A1 (no)
SK (1) SK10572002A3 (no)
SV (1) SV2001000288A (no)
TN (1) TNSN01011A1 (no)
UY (1) UY26551A1 (no)
WO (1) WO2001053273A1 (no)
YU (1) YU55902A (no)

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ID24703A (id) 1997-09-15 2000-08-03 Procter & Gamble Kuinolon antimikroba, komposisi dan penggunaannya
EP1395585B1 (en) 2001-05-30 2006-01-04 Warner-Lambert Company LLC Antibacterial agents
AU2002302894A1 (en) * 2001-06-19 2003-01-02 Warner-Lambert Company Llc Quinazolinediones as antibacterial agents
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
MXPA06002852A (es) * 2003-09-12 2006-06-14 Warner Lambert Co Agentes antibacterianos de quinolona.
EP1687296A1 (en) * 2003-11-18 2006-08-09 Warner-Lambert Company LLC Antibacterial aminoquinazolidinedione derivatives
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
JP4829900B2 (ja) * 2005-01-26 2011-12-07 エフ．ホフマン−ラ ロシュ アーゲー フェニルメタノン誘導体及びグリシントランスポーター１阻害剤としてのこれらの使用
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
ATE507219T1 (de) 2006-03-28 2011-05-15 Warner Chilcott Co Llc Malatsalze und polymorphe von (3s,5s)-7-ä3-amino- 5-methyl-piperidinylü-1-cyclopropyl-1,4-dihydro 8-methoxy-4-oxo-3-chinolincarbonsäure
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
KR101075435B1 (ko) * 2008-01-30 2011-10-24 신풍제약주식회사 신규한 퀴나졸린-2,4-디온 유도체 및 이를 함유하는 뇌신경질환 예방 및 치료용 의약 조성물
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AR085806A1 (es) 2011-03-15 2013-10-30 Trius Therapeutics Inc Inhibidores triciclicos de girasa
WO2013091539A1 (zh) * 2011-12-21 2013-06-27 江苏恒瑞医药股份有限公司 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用
PT3495367T (pt) 2012-06-13 2020-11-12 Incyte Holdings Corp Compostos tricíclicos substituídos como inibidores de fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
CN105189505B (zh) 2012-09-12 2019-03-22 默克夏普&多梅有限公司 用作抗菌剂的三环促旋酶抑制剂
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
MX393494B (es) 2013-04-19 2025-03-24 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr).
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CR20170390A (es) 2015-02-20 2017-10-23 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de fgfr
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN108530448A (zh) * 2017-03-02 2018-09-14 浙江司太立制药股份有限公司 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11174257B2 (en) 2018-05-04 2021-11-16 Incyte Corporation Salts of an FGFR inhibitor
WO2019213544A2 (en) 2018-05-04 2019-11-07 Incyte Corporation Solid forms of an fgfr inhibitor and processes for preparing the same
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021076602A1 (en) 2019-10-14 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
PE20221504A1 (es) 2019-12-04 2022-09-30 Incyte Corp Derivados de un inhibidor de fgfr
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
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EP0035619B1 (fr) * 1980-03-10 1984-07-25 BERRI-BALZAC Société dite: Dérivés d'amino-3 (1H,3H) quinazolinedione-2,4
GB2097784A (en) * 1981-04-28 1982-11-10 Davidson Dr John Stirton Dihydrobenzotriazepine diones; aminoquinazoline diones
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WO1998018781A2 (en) 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
AU9503998A (en) * 1997-10-28 1999-05-17 Warner-Lambert Company Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents
DE69939168D1 (de) * 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
ATE305003T1 (de) * 1998-12-11 2005-10-15 Hoffmann La Roche Zyklische hydrazinderivate als tnf-alpha inhibitoren

Also Published As

Publication number Publication date
PA8510101A1 (es) 2003-06-30
CA2393802A1 (en) 2001-07-26
CO5320600A1 (es) 2003-09-30
MXPA02005989A (es) 2002-10-23
EA005585B1 (ru) 2005-04-28
EP1255739B1 (en) 2008-06-11
BR0017010A (pt) 2002-11-05
ES2304992T3 (es) 2008-11-01
IL150393A0 (en) 2002-12-01
JP4811978B2 (ja) 2011-11-09
GEP20053429B (en) 2005-01-25
JP2003520277A (ja) 2003-07-02
PL356837A1 (en) 2004-07-12
US20060183762A1 (en) 2006-08-17
HRP20020696A2 (en) 2003-12-31
AP2002002603A0 (en) 2002-09-30
YU55902A (sh) 2006-01-16
CA2393802C (en) 2011-04-19
NO20023516L (no) 2002-07-23
KR20020067701A (ko) 2002-08-23
EA200200661A1 (ru) 2003-02-27
WO2001053273A1 (en) 2001-07-26
AU783078B2 (en) 2005-09-22
HUP0204101A3 (en) 2004-05-28
IS6448A (is) 2002-06-27
US7582627B2 (en) 2009-09-01
ATE398110T1 (de) 2008-07-15
HUP0204101A2 (hu) 2003-04-28
TNSN01011A1 (en) 2005-11-10
CR6709A (es) 2003-11-25
SK10572002A3 (sk) 2003-10-07
EP1255739A1 (en) 2002-11-13
AU2089901A (en) 2001-07-31
PE20011060A1 (es) 2001-10-12
US20060287308A1 (en) 2006-12-21
AR030186A1 (es) 2003-08-13
CN1425008A (zh) 2003-06-18
HK1054237A1 (zh) 2003-11-21
EE200200412A (et) 2003-10-15
US7094780B1 (en) 2006-08-22
HN2001000009A (es) 2001-06-13
MA26866A1 (fr) 2004-12-20
UY26551A1 (es) 2001-04-30
BG107023A (en) 2003-04-30
SV2001000288A (es) 2001-11-30
OA12316A (en) 2006-05-15
DE60039194D1 (de) 2008-07-24

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