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ATE398110T1 - 3-aminochinazolin-2,4-dione als antibakterielle mittel - Google Patents

3-aminochinazolin-2,4-dione als antibakterielle mittel

Info

Publication number
ATE398110T1
ATE398110T1 AT00984246T AT00984246T ATE398110T1 AT E398110 T1 ATE398110 T1 AT E398110T1 AT 00984246 T AT00984246 T AT 00984246T AT 00984246 T AT00984246 T AT 00984246T AT E398110 T1 ATE398110 T1 AT E398110T1
Authority
AT
Austria
Prior art keywords
aminoquinazoline
dione
antibacterial agent
antibacterial
agent
Prior art date
Application number
AT00984246T
Other languages
English (en)
Inventor
Paul Bird
Edmund Ellsworth
Dai Nguyen
Joseph SANCHEZ
Howard Showalter
Rajeshwar Singh
Michael STIER
Tuan Tran
Brian Watson
Judy Yip
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE398110T1 publication Critical patent/ATE398110T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
AT00984246T 2000-01-24 2000-12-12 3-aminochinazolin-2,4-dione als antibakterielle mittel ATE398110T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18

Publications (1)

Publication Number Publication Date
ATE398110T1 true ATE398110T1 (de) 2008-07-15

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00984246T ATE398110T1 (de) 2000-01-24 2000-12-12 3-aminochinazolin-2,4-dione als antibakterielle mittel

Country Status (38)

Country Link
US (2) US7094780B1 (de)
EP (1) EP1255739B1 (de)
JP (1) JP4811978B2 (de)
KR (1) KR20020067701A (de)
CN (1) CN1425008A (de)
AP (1) AP2002002603A0 (de)
AR (1) AR030186A1 (de)
AT (1) ATE398110T1 (de)
AU (1) AU783078B2 (de)
BG (1) BG107023A (de)
BR (1) BR0017010A (de)
CA (1) CA2393802C (de)
CO (1) CO5320600A1 (de)
CR (1) CR6709A (de)
DE (1) DE60039194D1 (de)
EA (1) EA005585B1 (de)
EE (1) EE200200412A (de)
ES (1) ES2304992T3 (de)
GE (1) GEP20053429B (de)
HK (1) HK1054237A1 (de)
HN (1) HN2001000009A (de)
HR (1) HRP20020696A2 (de)
HU (1) HUP0204101A3 (de)
IL (1) IL150393A0 (de)
IS (1) IS6448A (de)
MA (1) MA26866A1 (de)
MX (1) MXPA02005989A (de)
NO (1) NO20023516D0 (de)
OA (1) OA12316A (de)
PA (1) PA8510101A1 (de)
PE (1) PE20011060A1 (de)
PL (1) PL356837A1 (de)
SK (1) SK10572002A3 (de)
SV (1) SV2001000288A (de)
TN (1) TNSN01011A1 (de)
UY (1) UY26551A1 (de)
WO (1) WO2001053273A1 (de)
YU (1) YU55902A (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014214A1 (en) 1997-09-15 1999-03-25 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
DE60208541D1 (de) 2001-05-30 2006-03-30 Warner Lambert Co Antibakterielle mittel
MXPA03009894A (es) * 2001-06-19 2004-02-17 Warner Lambert Co Agentes antibacterianos.
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
WO2005026154A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
JP2007511597A (ja) * 2003-11-18 2007-05-10 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 抗菌アミノキナゾリヂンヂオン誘導体
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
DE602006010175D1 (de) * 2005-01-26 2009-12-17 Hoffmann La Roche Phenylmethanonderivate und ihre verwendung als glycin-transporter-1-hemmer
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
SMP200800058B (it) 2006-03-28 2009-09-07 Procter & Gamble Sali e polimorfi malati di un acido (3s, 5s) -7- [3-ammino-5-metilpiperidinil]-1-ciclopropil-1,4-diidro-8-metossi-4-osso-3-chinolincarbossilico
EP1999125A2 (de) 2006-03-28 2008-12-10 The Procter and Gamble Company Kopplungsverfahren zur herstellung von chinolon-zwischenverbindungen
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
JP5291124B2 (ja) * 2008-01-30 2013-09-18 シン・プーン・ファーマシューティカル・カンパニー・リミテッド 新規なキナゾリン−２，４−ジオン誘導体、及びこれを含有する脳神経系疾患の予防及び治療用医薬組成物
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AU2012229997B2 (en) 2011-03-15 2016-04-14 Lawrence Livermore National Security, Llc Tricyclic gyrase inhibitors
CA2857977C (en) * 2011-12-21 2020-10-20 Jiangsu Hengrui Medicine Co., Ltd. Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof
ES2984771T3 (es) 2012-06-13 2024-10-31 Incyte Holdings Corp Compuestos tricíclicos sustituidos como inhibidores de FGFR
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
EP2895488B1 (de) 2012-09-12 2024-12-11 Merck Sharp & Dohme LLC Tricyclische gyrase-inhibitoren zur verwendung als antibakterielle wirkstoffe
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
PE20171514A1 (es) 2015-02-20 2017-10-20 Incyte Corp Heterociclos biciclicos como inhibidores de fgfr
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN108530448A (zh) * 2017-03-02 2018-09-14 浙江司太立制药股份有限公司 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
BR112020022392A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation formas sólidas de um inibidor de fgfr e processos para preparação das mesmas
CR20200591A (es) 2018-05-04 2021-03-31 Incyte Corp Sales de un inhibidor de fgfr
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CN115835908A (zh) 2019-10-14 2023-03-21 因赛特公司 作为fgfr抑制剂的双环杂环
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2023505257A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤の誘導体
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
EP4323405A1 (de) 2021-04-12 2024-02-21 Incyte Corporation Kombinationstherapie mit einem fgfr-inhibitor und einem auf nectin-4 abzielenden mittel
EP4352059A1 (de) 2021-06-09 2024-04-17 Incyte Corporation Tricyclische heterocyclen als fgfr-inhibitoren

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1068263B (de) * 1959-11-05
FR1203542A (fr) * 1958-02-25 1960-01-19 Rhone Poulenc Sa Nouveaux dérivés de la phénothiazine comportant en position 10 une chaîne pipérazinique et leurs procédés de préparation
EP0035619B1 (de) * 1980-03-10 1984-07-25 BERRI-BALZAC Société dite: 3-Amino-(1H,3H)-2,4-chinazolindionderivate
GB2097784A (en) * 1981-04-28 1982-11-10 Davidson Dr John Stirton Dihydrobenzotriazepine diones; aminoquinazoline diones
AU5813394A (en) 1992-12-23 1994-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
WO1998018781A2 (en) 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
SI1028950T1 (en) 1997-10-28 2003-08-31 Warner-Lambert Company Llc 7-substituted quinazolin-2,4-diones useful as antibacterial agents
ATE402177T1 (de) * 1998-05-26 2008-08-15 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4- dihydropyrimidine als inhibitoren der zellvermehrung
WO2000035885A1 (en) * 1998-12-11 2000-06-22 F. Hoffmann-La Roche Ag Cyclic hydrazine derivatives as tnf-alpha inhibitors

Also Published As

Publication number Publication date
HK1054237A1 (zh) 2003-11-21
PL356837A1 (en) 2004-07-12
US20060183762A1 (en) 2006-08-17
CO5320600A1 (es) 2003-09-30
JP2003520277A (ja) 2003-07-02
HN2001000009A (es) 2001-06-13
GEP20053429B (en) 2005-01-25
NO20023516L (no) 2002-07-23
UY26551A1 (es) 2001-04-30
JP4811978B2 (ja) 2011-11-09
HRP20020696A2 (en) 2003-12-31
KR20020067701A (ko) 2002-08-23
IL150393A0 (en) 2002-12-01
CN1425008A (zh) 2003-06-18
CA2393802A1 (en) 2001-07-26
MA26866A1 (fr) 2004-12-20
SK10572002A3 (sk) 2003-10-07
SV2001000288A (es) 2001-11-30
NO20023516D0 (no) 2002-07-23
CA2393802C (en) 2011-04-19
OA12316A (en) 2006-05-15
AP2002002603A0 (en) 2002-09-30
PA8510101A1 (es) 2003-06-30
IS6448A (is) 2002-06-27
EE200200412A (et) 2003-10-15
US7582627B2 (en) 2009-09-01
US7094780B1 (en) 2006-08-22
MXPA02005989A (es) 2002-10-23
DE60039194D1 (de) 2008-07-24
BR0017010A (pt) 2002-11-05
AU783078B2 (en) 2005-09-22
US20060287308A1 (en) 2006-12-21
YU55902A (sh) 2006-01-16
EP1255739A1 (de) 2002-11-13
CR6709A (es) 2003-11-25
EP1255739B1 (de) 2008-06-11
BG107023A (en) 2003-04-30
PE20011060A1 (es) 2001-10-12
WO2001053273A1 (en) 2001-07-26
AU2089901A (en) 2001-07-31
HUP0204101A3 (en) 2004-05-28
HUP0204101A2 (hu) 2003-04-28
AR030186A1 (es) 2003-08-13
EA005585B1 (ru) 2005-04-28
EA200200661A1 (ru) 2003-02-27
ES2304992T3 (es) 2008-11-01
TNSN01011A1 (en) 2005-11-10

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