[go: up one dir, main page]

NL8701909A - 1-(4-aminofenyl)-4-methyl-7,8-methyleendioxy-3,4-dihydro-5h-2,3-benzodiazepine, zuur-additiezouten daarvan en werkwijze voor de bereiding ervan. - Google Patents

1-(4-aminofenyl)-4-methyl-7,8-methyleendioxy-3,4-dihydro-5h-2,3-benzodiazepine, zuur-additiezouten daarvan en werkwijze voor de bereiding ervan. Download PDF

Info

Publication number
NL8701909A
NL8701909A NL8701909A NL8701909A NL8701909A NL 8701909 A NL8701909 A NL 8701909A NL 8701909 A NL8701909 A NL 8701909A NL 8701909 A NL8701909 A NL 8701909A NL 8701909 A NL8701909 A NL 8701909A
Authority
NL
Netherlands
Prior art keywords
formula
hydride
dihydro
compound
acid addition
Prior art date
Application number
NL8701909A
Other languages
English (en)
Dutch (nl)
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of NL8701909A publication Critical patent/NL8701909A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
NL8701909A 1986-08-15 1987-08-14 1-(4-aminofenyl)-4-methyl-7,8-methyleendioxy-3,4-dihydro-5h-2,3-benzodiazepine, zuur-additiezouten daarvan en werkwijze voor de bereiding ervan. NL8701909A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU359486 1986-08-15

Publications (1)

Publication Number Publication Date
NL8701909A true NL8701909A (nl) 1988-03-01

Family

ID=10964707

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8701909A NL8701909A (nl) 1986-08-15 1987-08-14 1-(4-aminofenyl)-4-methyl-7,8-methyleendioxy-3,4-dihydro-5h-2,3-benzodiazepine, zuur-additiezouten daarvan en werkwijze voor de bereiding ervan.

Country Status (23)

Country Link
US (1) US4835152A (no)
JP (1) JPS6399073A (no)
AT (1) ATA202187A (no)
AU (1) AU596206B2 (no)
BE (1) BE1002415A4 (no)
CA (1) CA1284322C (no)
CH (1) CH673652A5 (no)
CS (1) CS264150B2 (no)
DD (1) DD265627A5 (no)
DE (1) DE3727226A1 (no)
DK (1) DK164555C (no)
ES (1) ES2004985A6 (no)
FI (1) FI85706C (no)
FR (1) FR2602773B1 (no)
GB (1) GB2194236B (no)
HU (1) HU198494B (no)
IT (1) IT1222508B (no)
NL (1) NL8701909A (no)
NO (1) NO164656C (no)
PL (1) PL148535B1 (no)
RU (1) RU1779251C (no)
SE (1) SE467357B (no)
YU (1) YU46223B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
US6288057B1 (en) * 1994-08-31 2001-09-11 Eli Lilly And Company Physical form of dihydro-2,3-benzodiazepine derivative
TR199501071A2 (tr) 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
EP1575521A4 (en) * 2002-12-03 2008-04-30 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
EP1624875A4 (en) * 2003-05-16 2010-01-20 Vela Acquisition Corp TREATMENT OF GASTROINTESTINAL DYSFUNCTION AND RELATED LOADS WITH ENANTIOMERIC PURE (R) 2,3-BENZODIAZEPINE
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US20050096464A1 (en) * 2003-10-30 2005-05-05 Heikki Heikkila Separation process
EP4197536A1 (en) * 2021-12-20 2023-06-21 Universitat de València Haloperidol for use in the treatment of spinal muscular atrophy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
DE3319491A1 (de) * 1982-06-19 1983-10-13 Alps Electric Co., Ltd., Tokyo Papierfuehrungsmechanismus fuer schreibgeraete
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
NO164656B (no) 1990-07-23
FI873525A0 (fi) 1987-08-14
GB2194236A (en) 1988-03-02
FI873525A (fi) 1988-02-16
AU7688087A (en) 1988-02-18
GB8719265D0 (en) 1987-09-23
DK424887D0 (da) 1987-08-14
BE1002415A4 (fr) 1991-02-05
FR2602773A1 (fr) 1988-02-19
US4835152A (en) 1989-05-30
ES2004985A6 (es) 1989-02-16
DK164555B (da) 1992-07-13
CS264150B2 (en) 1989-06-13
YU46223B (sh) 1993-05-28
RU1779251C (ru) 1992-11-30
PL148535B1 (en) 1989-10-31
SE8703169D0 (sv) 1987-08-14
IT8721667A0 (it) 1987-08-14
DK424887A (da) 1988-02-16
DK164555C (da) 1992-11-30
HU198494B (en) 1989-10-30
GB2194236B (en) 1990-03-21
ATA202187A (de) 1993-06-15
NO873426L (no) 1988-02-16
DD265627A5 (de) 1989-03-08
FR2602773B1 (fr) 1990-11-02
SE467357B (sv) 1992-07-06
NO164656C (no) 1990-10-31
HUT47287A (en) 1989-02-28
DE3727226A1 (de) 1988-02-18
NO873426D0 (no) 1987-08-14
CA1284322C (en) 1991-05-21
FI85706C (fi) 1992-05-25
IT1222508B (it) 1990-09-05
CS600787A2 (en) 1988-08-16
FI85706B (fi) 1992-02-14
AU596206B2 (en) 1990-04-26
YU151487A (en) 1988-12-31
JPS6399073A (ja) 1988-04-30
SE8703169L (sv) 1988-02-16
CH673652A5 (no) 1990-03-30

Similar Documents

Publication Publication Date Title
NL8701909A (nl) 1-(4-aminofenyl)-4-methyl-7,8-methyleendioxy-3,4-dihydro-5h-2,3-benzodiazepine, zuur-additiezouten daarvan en werkwijze voor de bereiding ervan.
EP0618906B1 (en) Substituted imidazole derivatives and their preparation and use
GB2243832A (en) 2-substituted 4-acetamido-5-chloro-n-[2-(diethylamino)ethyl]-benzamide derivative
EP0662971B1 (fr) DERIVES DE 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT
CZ291520B6 (cs) Nové deriváty 2,3-benzodiazepinu
US4791132A (en) Phenyl, Pyrrolidin-2-yl substituted pyrroles having antipsychotic properties
JP2868813B2 (ja) 置換イミダゾール、その製造法およびそれを有効成分とするα２−受容体拮抗医薬組成物
EP0114850B1 (fr) Nouveaux derives substitues du 2,5-diamino 1,4-diazole, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
BE1009852A3 (fr) Derives 1-[2(vinyl-substitues)]-3-4-dihydro-5h-2,3-benzodiazepine.
RO111573B1 (ro) Derivati de indenoindol
US4880801A (en) Heterocyclic amino compounds
CZ282249B6 (cs) Nový derivát 5H-benzodiazepinu, způsob jeho pří pravy a farmaceutický prostředek, který ho obsa huje
CZ53998A3 (cs) Sulfonamidové substituované anelované sloučeniny se sedmičlenným kruhem, jejich použití a farmaceutické prostředky, které je obsahují
CN111233820B (zh) 含有冠醚和二(2-甲氧基乙氧基)结构的芬戈莫德衍生物
JPS62283967A (ja) ド−パミン−β−ヒドロキシラ−ゼ抑制剤
JPH06102660B2 (ja) 新規なモルホリン誘導体およびこれらの誘導体を含有する医薬組成物
CN118930553A (zh) 5,6,7,8-四氢呋喃[3,4-g]异喹啉-3(1H)-酮化合物及其制备方法、药物组合物和用途
EP0804433A1 (en) Indole derivative for the treatment of migraine
JPH0615530B2 (ja) 多環式ベンズアゼピン
SI9300034A (sl) Substituirani derivati imidazola in njihova priprava in uporaea

Legal Events

Date Code Title Description
BV The patent application has lapsed