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ME03452B - Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora - Google Patents

Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora

Info

Publication number
ME03452B
ME03452B MEP-2019-199A MEP2019199A ME03452B ME 03452 B ME03452 B ME 03452B ME P2019199 A MEP2019199 A ME P2019199A ME 03452 B ME03452 B ME 03452B
Authority
ME
Montenegro
Prior art keywords
dropyrrolo
octahy
disubstituted
pyrrole
receptor modulators
Prior art date
Application number
MEP-2019-199A
Other languages
German (de)
English (en)
French (fr)
Inventor
Wenying Chai
Michael A Letavic
Kiev S Ly
Daniel J Pippel
Dale A Rudolph
Kathleen C Strother
Brad M Savall
Chandravadan R Shah
Brock T Shireman
Akinola Soyode-Johnson
Emily M Stocking
Devin M Swanson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ME03452B publication Critical patent/ME03452B/me

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MEP-2019-199A 2009-10-23 2010-10-21 Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora ME03452B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25450909P 2009-10-23 2009-10-23
EP16163733.5A EP3093291B1 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators

Publications (1)

Publication Number Publication Date
ME03452B true ME03452B (me) 2020-01-20

Family

ID=43385633

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2016-135A ME02437B (me) 2009-10-23 2010-10-21 Disupstituirani oktahidropirolo[3,4-c]piroli kao modulatori oreksin receptora
MEP-2019-199A ME03452B (me) 2009-10-23 2010-10-21 Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-2016-135A ME02437B (me) 2009-10-23 2010-10-21 Disupstituirani oktahidropirolo[3,4-c]piroli kao modulatori oreksin receptora

Country Status (39)

Country Link
US (8) US8653263B2 (me)
EP (3) EP3581575A1 (me)
JP (1) JP5759470B2 (me)
KR (3) KR101859409B1 (me)
CN (1) CN102781942B (me)
AR (2) AR078731A1 (me)
AU (2) AU2010310595B2 (me)
BR (1) BR112012010820B1 (me)
CA (1) CA2778484C (me)
CL (1) CL2010001162A1 (me)
CO (1) CO6541572A2 (me)
CR (1) CR20120273A (me)
CY (2) CY1117743T1 (me)
DK (2) DK3093291T3 (me)
EA (1) EA022766B1 (me)
EC (1) ECSP12011908A (me)
ES (2) ES2735411T3 (me)
HK (2) HK1175463A1 (me)
HR (2) HRP20160781T1 (me)
HU (2) HUE028650T2 (me)
IL (1) IL219234A (me)
JO (2) JO3267B1 (me)
LT (1) LT3093291T (me)
ME (2) ME02437B (me)
MX (1) MX2012004753A (me)
NI (1) NI201200062A (me)
NZ (1) NZ599629A (me)
PE (1) PE20110404A1 (me)
PH (1) PH12012500796A1 (me)
PL (2) PL3093291T3 (me)
PT (2) PT2491038T (me)
RS (2) RS54945B1 (me)
SI (2) SI3093291T1 (me)
SM (2) SMT201900392T1 (me)
TR (1) TR201910327T4 (me)
TW (1) TWI481613B (me)
UA (1) UA107812C2 (me)
UY (1) UY32966A (me)
WO (1) WO2011050198A1 (me)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3093291T3 (pl) * 2009-10-23 2019-11-29 Janssen Pharmaceutica Nv Dipodstawione oktahydropirolo[3,4-c]pirole jako modulatory receptora oreksyny
WO2012145581A1 (en) * 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
US8501768B2 (en) * 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
EA024106B1 (ru) 2011-11-08 2016-08-31 Актелион Фармасьютиклз Лтд. Производные 2-(1,2,3-триазол-2-ил)бензамида и 3-(1,2,3-триазол-2-ил)пиколинамида
WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
BR112014030173B1 (pt) 2012-06-04 2022-10-04 Idorsia Pharmaceuticals Ltd Composto derivado de benzimidazol-prolina, e, composição farmacêutica
JP6254163B2 (ja) * 2012-08-16 2017-12-27 ザ スクリプス リサーチ インスティテュート 新規カッパオピオイドリガンド
KR102151288B1 (ko) 2012-10-10 2020-09-03 이도르시아 파마슈티컬스 리미티드 [오르토 바이 (헤테로 )아릴]-[2-(메타 바이 (헤테로 )아릴)-피롤리딘-1-일]-메타논 유도체인 오렉신 수용체 안타고니스트
CN103012293A (zh) * 2012-12-13 2013-04-03 同济大学 一种抗失眠药物mk-4305中间体的合成方法
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