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BRPI0916657A2 - pirrolidin-3-ilmetil-amina como antagonistas de orexina - Google Patents

pirrolidin-3-ilmetil-amina como antagonistas de orexina

Info

Publication number
BRPI0916657A2
BRPI0916657A2 BRPI0916657-2A BRPI0916657A BRPI0916657A2 BR PI0916657 A2 BRPI0916657 A2 BR PI0916657A2 BR PI0916657 A BRPI0916657 A BR PI0916657A BR PI0916657 A2 BRPI0916657 A2 BR PI0916657A2
Authority
BR
Brazil
Prior art keywords
pyrrolidin
orexin antagonists
ylmethyl amine
orexin
ylmethyl
Prior art date
Application number
BRPI0916657-2A
Other languages
English (en)
Inventor
Knust Henner
Nettekoven Matthias
Pinard Emmanuel
Roche Olivier
Rogers-Evans Mark
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of BRPI0916657A2 publication Critical patent/BRPI0916657A2/pt

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

pirrolidin-3-ilmetil-amina como antagonistasde orexina". a presente invenção refere-se a compostos de fórmula (i) em que r1, r2, ar, hetarila, m e n são como descritos na descrição e reivindicações. os compostos são antagonistas de receptores de orexina que podem ser úteis no tratamento de distúrbios, em que trilhas de orexina estão envolvidas.
BRPI0916657-2A 2008-07-29 2009-07-20 pirrolidin-3-ilmetil-amina como antagonistas de orexina BRPI0916657A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08161316.3 2008-07-29
EP08161316 2008-07-29
PCT/EP2009/059271 WO2010012620A1 (en) 2008-07-29 2009-07-20 Pyrrolidin-3-ylmethyl-amine as orexin antagonists

Publications (1)

Publication Number Publication Date
BRPI0916657A2 true BRPI0916657A2 (pt) 2019-03-26

Family

ID=41056722

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916657-2A BRPI0916657A2 (pt) 2008-07-29 2009-07-20 pirrolidin-3-ilmetil-amina como antagonistas de orexina

Country Status (13)

Country Link
US (3) US7923470B2 (pt)
EP (1) EP2303871B1 (pt)
JP (1) JP5301665B2 (pt)
KR (1) KR101359852B1 (pt)
CN (1) CN102083820B (pt)
AT (1) ATE557019T1 (pt)
AU (1) AU2009276091A1 (pt)
BR (1) BRPI0916657A2 (pt)
CA (1) CA2731403C (pt)
ES (1) ES2386526T3 (pt)
IL (1) IL209629A0 (pt)
MX (1) MX2011000462A (pt)
WO (1) WO2010012620A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE383359T1 (de) * 2001-05-05 2008-01-15 Smithkline Beecham Plc N-aroyl zyklische amine
ME02437B (me) 2009-10-23 2016-09-20 Janssen Pharmaceutica Nv Disupstituirani oktahidropirolo[3,4-c]piroli kao modulatori oreksin receptora
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
BR112014019426A8 (pt) 2012-02-07 2017-07-11 Eolas Therapeutics Inc Prolinas/ piperidinas substituídas como antagonistas do receptor de orexina
AR101558A1 (es) 2014-08-13 2016-12-28 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores del receptor de orexina
AU2017217931B2 (en) 2016-02-12 2020-10-22 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
IL288321B2 (en) 2016-03-10 2025-08-01 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
EP4110764A1 (en) * 2020-02-26 2023-01-04 The Scripps Research Institute Small molecule inhibitors of scl15a4 with anti-inflammatory activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE383359T1 (de) * 2001-05-05 2008-01-15 Smithkline Beecham Plc N-aroyl zyklische amine
AU2006236387A1 (en) * 2005-04-18 2006-10-26 Neurogen Corporation Subtituted heteroaryl CB1 antagonists
WO2009080533A1 (en) * 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heteroaryl derivatives as orexin receptor antagonists

Also Published As

Publication number Publication date
WO2010012620A1 (en) 2010-02-04
EP2303871B1 (en) 2012-05-09
US20120232084A1 (en) 2012-09-13
US20110071154A1 (en) 2011-03-24
US8748430B2 (en) 2014-06-10
US7923470B2 (en) 2011-04-12
MX2011000462A (es) 2011-04-05
IL209629A0 (en) 2011-02-28
EP2303871A1 (en) 2011-04-06
ATE557019T1 (de) 2012-05-15
KR101359852B1 (ko) 2014-02-06
JP5301665B2 (ja) 2013-09-25
US8207220B2 (en) 2012-06-26
CA2731403A1 (en) 2010-02-04
ES2386526T3 (es) 2012-08-22
CA2731403C (en) 2013-11-05
CN102083820B (zh) 2013-07-17
AU2009276091A1 (en) 2010-02-04
KR20110013535A (ko) 2011-02-09
JP2011529096A (ja) 2011-12-01
CN102083820A (zh) 2011-06-01
US20100029664A1 (en) 2010-02-04

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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B350 Update of information on the portal [chapter 15.35 patent gazette]