LU88559A1 - Sels de peptides comprenant des polyesters à terminaison carboxy - Google Patents
Sels de peptides comprenant des polyesters à terminaison carboxy Download PDFInfo
- Publication number
- LU88559A1 LU88559A1 LU88559A LU88559A LU88559A1 LU 88559 A1 LU88559 A1 LU 88559A1 LU 88559 A LU88559 A LU 88559A LU 88559 A LU88559 A LU 88559A LU 88559 A1 LU88559 A1 LU 88559A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- carboxy
- peptides
- salts
- terminated polyesters
- polyesters
- Prior art date
Links
- 229920000728 polyester Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB@@@@A GB9211268D0 (en) | 1992-05-28 | 1992-05-28 | Salts of basic peptides with carboxyterminated polyesters |
PCT/GB1993/001079 WO1993024150A1 (fr) | 1992-05-28 | 1993-05-25 | Sels de peptides comprenant des polyesters a terminaison carboxy |
Publications (1)
Publication Number | Publication Date |
---|---|
LU88559A1 true LU88559A1 (fr) | 1995-04-05 |
Family
ID=10716132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU88559A LU88559A1 (fr) | 1992-05-28 | 1994-11-23 | Sels de peptides comprenant des polyesters à terminaison carboxy |
Country Status (33)
Country | Link |
---|---|
US (3) | US5889110A (fr) |
JP (1) | JPH08501064A (fr) |
KR (1) | KR100293882B1 (fr) |
AT (1) | AT407702B (fr) |
AU (1) | AU682310B2 (fr) |
BE (1) | BE1006143A3 (fr) |
CA (1) | CA2136751C (fr) |
CH (2) | CH690491A5 (fr) |
CZ (1) | CZ292449B6 (fr) |
DE (2) | DE4392401B4 (fr) |
DK (1) | DK176134B1 (fr) |
ES (1) | ES2107357B1 (fr) |
FI (1) | FI112603B (fr) |
FR (1) | FR2691631B1 (fr) |
GB (3) | GB9211268D0 (fr) |
GR (1) | GR1001550B (fr) |
HK (1) | HK133097A (fr) |
HU (1) | HUT70177A (fr) |
IE (1) | IE74715B1 (fr) |
IL (1) | IL105710A (fr) |
IT (1) | IT1271139B (fr) |
LU (1) | LU88559A1 (fr) |
MC (1) | MC2330A1 (fr) |
NL (1) | NL195056C (fr) |
NO (1) | NO311006B1 (fr) |
NZ (1) | NZ252268A (fr) |
RU (1) | RU2152225C1 (fr) |
SE (1) | SE501970C2 (fr) |
SG (1) | SG44645A1 (fr) |
SK (1) | SK280320B6 (fr) |
TW (1) | TW223018B (fr) |
WO (1) | WO1993024150A1 (fr) |
ZA (1) | ZA933358B (fr) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
CN1146402C (zh) * | 1996-12-20 | 2004-04-21 | 阿尔萨公司 | 凝胶组合物及方法 |
US20020182258A1 (en) * | 1997-01-22 | 2002-12-05 | Zycos Inc., A Delaware Corporation | Microparticles for delivery of nucleic acid |
US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6117949A (en) * | 1998-10-01 | 2000-09-12 | Macromed, Inc. | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
EP1240896A3 (fr) * | 1998-07-23 | 2003-03-26 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Encapsulation de peptides hydrosolubles |
US20070009605A1 (en) * | 1998-07-23 | 2007-01-11 | Ignatious Francis X | Encapsulation of water soluble peptides |
US20030166525A1 (en) * | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
CO5160256A1 (es) * | 1999-02-08 | 2002-05-30 | Zentaris Ag | Sales de peptidos farmaceuticamente activos para la liberacion sostenida y proceso de produccion |
US7018645B1 (en) | 2000-04-27 | 2006-03-28 | Macromed, Inc. | Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties |
US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
WO2001093835A1 (fr) * | 2000-06-02 | 2001-12-13 | Zycos Inc. | Systemes de distribution d'agents bioactifs |
WO2002036169A2 (fr) * | 2000-10-31 | 2002-05-10 | Pr Pharmaceuticals, Inc. | Methodes et compositions pour ameliorer l'administration de molecules bioactives |
AU2002324447B2 (en) | 2001-06-22 | 2006-06-29 | Durect Corporation | Zero-order prolonged release coaxial implants |
US6873915B2 (en) * | 2001-08-24 | 2005-03-29 | Surromed, Inc. | Peak selection in multidimensional data |
PT1429731E (pt) * | 2001-09-19 | 2007-04-30 | Elan Pharma Int Ltd | Formulações de insulina nanoparticulada |
AU2002335077B2 (en) * | 2001-10-19 | 2006-09-07 | Idexx Laboratories, Inc. | Injectable compositions for the controlled delivery of pharmacologically active compound |
KR20040058101A (ko) * | 2001-11-14 | 2004-07-03 | 알자 코포레이션 | 카테터 주입가능한 데포 조성물 및 그의 용도 |
ATE507816T1 (de) * | 2001-11-14 | 2011-05-15 | Durect Corp | Injizierbare depotzusammensetzungen und deren verwendung |
US20070196415A1 (en) * | 2002-11-14 | 2007-08-23 | Guohua Chen | Depot compositions with multiple drug release rate controls and uses thereof |
DE10206517A1 (de) * | 2002-02-16 | 2003-09-04 | Stoess & Co Gelatine | Depotarzneimittel, Trägermaterialien für Depotarzneimittel und Verfahren zu deren Herstellung |
ATE374598T1 (de) * | 2002-03-15 | 2007-10-15 | Alrise Biosystems Gmbh | Mikropartikel und verfahren zur deren herstellung |
US9101540B2 (en) * | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
AU2003244157A1 (en) | 2002-06-25 | 2004-01-06 | Takeda Pharmaceutical Company Limited | Process for producing sustained-release composition |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
AR039729A1 (es) * | 2002-06-25 | 2005-03-09 | Alza Corp | Formulaciones de deposito de corta duracion |
AU2002359397B2 (en) * | 2002-07-31 | 2009-01-29 | Durect Corporation | Injectable depot compositions and uses thereof |
BR0313539A (pt) * | 2002-07-31 | 2005-06-21 | Alza Corp | Composições depósito de polìmero multimodais injetáveis e seus usos |
CN104383554B (zh) | 2002-09-06 | 2018-06-08 | 天蓝制药公司 | 用于传递治疗剂的以环糊精为基础的聚合物 |
CN1713890A (zh) | 2002-11-06 | 2005-12-28 | 阿尔萨公司 | 控释储库制剂 |
DK1911763T3 (da) | 2003-01-28 | 2010-11-15 | Ironwood Pharmaceuticals Inc | Sammensætninger til behandling af mavetarmsygdomme |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7741268B2 (en) * | 2003-04-02 | 2010-06-22 | Ares Trading S.A. | Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant |
US20040224024A1 (en) * | 2003-04-23 | 2004-11-11 | Massachusetts Institute Of Technology | Controlled drug release formulations containing polyion complexes |
US20050112087A1 (en) * | 2003-04-29 | 2005-05-26 | Musso Gary F. | Pharmaceutical formulations for sustained drug delivery |
WO2004112826A1 (fr) * | 2003-06-20 | 2004-12-29 | Ares Trading Sa | Formulations lyophilisees a base de fsh/lh |
EP1660013A4 (fr) | 2003-08-26 | 2011-07-20 | Gel Del Technologies Inc | Biomateriaux et biocoacervats proteiniques, leurs procedes de fabrication et d'utilisation |
US20050049210A1 (en) * | 2003-08-27 | 2005-03-03 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
EP1682537B1 (fr) | 2003-11-05 | 2012-03-28 | SARcode Bioscience Inc. | Modulateurs de l'adhesion cellulaire |
US8529939B2 (en) | 2003-12-08 | 2013-09-10 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
WO2005074968A2 (fr) * | 2004-02-10 | 2005-08-18 | Universiteit Maastricht | Utilisation medicale de peptides basiques |
TW200529890A (en) * | 2004-02-10 | 2005-09-16 | Takeda Pharmaceutical | Sustained-release preparations |
US9028829B2 (en) * | 2004-02-20 | 2015-05-12 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
US8562505B2 (en) * | 2004-02-20 | 2013-10-22 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
US7846201B2 (en) * | 2004-02-20 | 2010-12-07 | The Children's Hospital Of Philadelphia | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
EP1674082A1 (fr) * | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Procédé pour la manufacture des suspensions ou lyophilisates steriles des complexes mal-soluble de peptides basic, des formulations pharmaceutiques avec ces complexes et leur utilisation comme medicament |
CN102617557A (zh) | 2005-05-17 | 2012-08-01 | 萨可德生物科学公司 | 治疗眼病的组合物和方法 |
US8882747B2 (en) * | 2005-11-09 | 2014-11-11 | The Invention Science Fund I, Llc | Substance delivery system |
US8945598B2 (en) * | 2005-12-29 | 2015-02-03 | Cordis Corporation | Low temperature drying methods for forming drug-containing polymeric compositions |
EP1837014A1 (fr) * | 2006-03-21 | 2007-09-26 | Hexal Ag | Implants sous-cutanés contenant un polymère de polylactide résistant à la dégradation et un analogue de la LH-RH |
ITMI20061538A1 (it) * | 2006-08-02 | 2008-02-03 | Mediolanum Pharmaceuticals Ltd | Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo |
EP1917971A1 (fr) * | 2006-10-27 | 2008-05-07 | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) | Préparations à libération prolongée comprenant des polymères à poids moléculaire très bas |
KR100816065B1 (ko) | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐 |
US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA3089569C (fr) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles |
MX2010004281A (es) | 2007-10-19 | 2010-09-10 | Sarcode Corp | Composiciones y metodos para el tratamiento de la retinopatia diabetica. |
US20090163449A1 (en) * | 2007-12-20 | 2009-06-25 | Eastman Chemical Company | Sulfo-polymer powder and sulfo-polymer powder blends with carriers and/or additives |
US20090163603A1 (en) * | 2007-12-20 | 2009-06-25 | Eastman Chemical Company | Sulfo-polymer powder and sulfo-polymer powder blends |
WO2009086483A2 (fr) | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Particules de protéines biocompatibles, dispositifs à particules et leurs procédés |
JOP20090061B1 (ar) * | 2008-02-11 | 2021-08-17 | Ferring Int Center Sa | طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH |
WO2009139817A2 (fr) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Produit pharmaceutique cristallin et ses procédés de préparation et d'utilisation |
WO2009149279A2 (fr) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
WO2010009319A2 (fr) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres |
WO2010057177A2 (fr) | 2008-11-17 | 2010-05-20 | Gel-Del Technologies, Inc. | Systèmes de greffe de vaisseaux à biocoacervats et biomatériaux protéiques et procédés pour leur fabrication et leur utilisation |
US8822546B2 (en) * | 2008-12-01 | 2014-09-02 | Medtronic, Inc. | Flowable pharmaceutical depot |
CA2774015A1 (fr) | 2009-09-15 | 2011-03-24 | Cerulean Pharma Inc. | Conjugue de cdp-camptothecine, composition a distribution des orientations de particules et leurs utilisations |
US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
ES2434315T3 (es) * | 2009-12-22 | 2013-12-16 | Takeda Pharmaceutical Company Limited | Formulación de liberación sostenida |
DE102010003615A1 (de) | 2010-04-01 | 2011-10-06 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Verfahren zur Herstellung eines Drug-Delivery-Systems auf der Basis von Polyelektrolytkomplexen |
CA2927832C (fr) | 2010-05-18 | 2021-03-23 | Cerulean Pharma Inc. | Conjugues d'agent therapeutique polymere renfermant de la cyclodextrine et leur utilisation |
EP2585092A1 (fr) | 2010-06-24 | 2013-05-01 | Torrent Pharmaceuticals Limited | Composition pharmaceutique contenant de la goséréline pour un implant in situ |
UY33465A (es) * | 2010-06-25 | 2012-01-31 | Takeda Pharmaceutical | Formulacion de liberacion sostenida |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
ES2579319T3 (es) | 2011-05-04 | 2016-08-09 | Balance Therapeutics, Inc. | Derivados de pentilenotetrazol |
KR101467275B1 (ko) * | 2011-12-19 | 2014-12-02 | 주식회사 삼양바이오팜 | 분산성이 향상된 생분해성 고분자 미립자의 조성물 및 그 제조방법 |
IN2015DN00847A (fr) | 2012-07-25 | 2015-06-12 | Sarcode Bioscience Inc | |
WO2014055493A1 (fr) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Procédés et systèmes s'appliquant à la précipitation de polymères et à la génération de particules |
US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
ES2804702T3 (es) * | 2013-03-04 | 2021-02-09 | Besins Healthcare Lu Sarl | Composiciones farmacéuticas secas que comprenden nanopartículas de agente activo unidas a partículas de portador |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
WO2014151200A2 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
CN106061494A (zh) | 2013-10-10 | 2016-10-26 | 辛纳吉制药公司 | 可用于治疗阿片样物质诱导的功能障碍的鸟苷酸环化酶的激动剂 |
CA2931547A1 (fr) | 2013-12-09 | 2015-06-18 | Durect Corporation | Complexes de principes pharmaceutiquement actifs, complexes de polymeres, et compositions et procedes les impliquant |
US11389473B2 (en) | 2015-01-07 | 2022-07-19 | Tonix Pharmaceuticals Holding Corp. | Magnesium-containing oxytocin formulations and methods of use |
US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9375478B1 (en) | 2015-01-30 | 2016-06-28 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
US10653744B2 (en) | 2016-01-11 | 2020-05-19 | Bausch Health Ireland Limited | Formulations and methods for treating ulcerative colitis |
US12156897B2 (en) | 2016-04-12 | 2024-12-03 | Tonix Pharma Limited | Magnesium-containing oxytocin formulations and methods of use |
CN105963258B (zh) * | 2016-04-26 | 2021-01-22 | 广州帝奇医药技术有限公司 | 一种缓释微粒的制备方法 |
CN110954491B (zh) * | 2019-12-09 | 2022-11-15 | 北京博恩特药业有限公司 | 用于测量醋酸戈舍瑞林缓释植入剂体外溶出度的方法 |
KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
EP4192509A1 (fr) | 2020-08-05 | 2023-06-14 | Ellipses Pharma Ltd | Traitement du cancer à l'aide d'un conjugué polymère contenant de la cyclodextrine-inhibiteur de la topoisomérase et d'un inhibiteur de parp |
US20250009647A1 (en) | 2021-08-05 | 2025-01-09 | Medincell S.A. | Pharmaceutical composition |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US5005602A (en) * | 1985-12-24 | 1991-04-09 | Dover Corporation | Poppet valve assembly |
FR2600894B1 (fr) * | 1986-07-02 | 1989-01-13 | Centre Nat Rech Scient | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
JP2827287B2 (ja) * | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US4997643A (en) * | 1989-07-12 | 1991-03-05 | Union Carbide Chemicals And Plastics Company Inc. | Polymeric salt delivery systems |
US5077049A (en) * | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
CH679207A5 (fr) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
CA2065156A1 (fr) * | 1990-07-03 | 1992-01-04 | Richard L. Dunn | Systemes de liberation intragingival pour le traitement d'une maladie periodontique |
CA2046830C (fr) * | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Systeme d'administration des medicaments comprenant une interaction entre une proteine ou une polypeptide et un polymere hydrophobe biodegradable |
GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
US5672659A (en) * | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
-
1992
- 1992-05-28 GB GB@@@@A patent/GB9211268D0/en active Pending
-
1993
- 1993-05-11 GB GB939309645A patent/GB9309645D0/en active Pending
- 1993-05-11 IE IE930358A patent/IE74715B1/en not_active IP Right Cessation
- 1993-05-13 ZA ZA933358A patent/ZA933358B/xx unknown
- 1993-05-16 IL IL10571093A patent/IL105710A/en not_active IP Right Cessation
- 1993-05-21 TW TW082104017A patent/TW223018B/zh not_active IP Right Cessation
- 1993-05-25 RU RU94046097/14A patent/RU2152225C1/ru not_active IP Right Cessation
- 1993-05-25 ES ES09450004A patent/ES2107357B1/es not_active Expired - Fee Related
- 1993-05-25 NL NL9320034A patent/NL195056C/nl not_active IP Right Cessation
- 1993-05-25 SK SK1434-94A patent/SK280320B6/sk not_active IP Right Cessation
- 1993-05-25 CZ CZ19942937A patent/CZ292449B6/cs not_active IP Right Cessation
- 1993-05-25 AU AU40847/93A patent/AU682310B2/en not_active Ceased
- 1993-05-25 GB GB9423366A patent/GB2282066B/en not_active Expired - Fee Related
- 1993-05-25 CH CH00680/98A patent/CH690491A5/de not_active IP Right Cessation
- 1993-05-25 KR KR1019940704279A patent/KR100293882B1/ko not_active IP Right Cessation
- 1993-05-25 DE DE4392401A patent/DE4392401B4/de not_active Expired - Fee Related
- 1993-05-25 HU HU9403371A patent/HUT70177A/hu unknown
- 1993-05-25 CH CH00311/94A patent/CH688911A5/de not_active IP Right Cessation
- 1993-05-25 CA CA002136751A patent/CA2136751C/fr not_active Expired - Fee Related
- 1993-05-25 AT AT0901993A patent/AT407702B/de not_active IP Right Cessation
- 1993-05-25 WO PCT/GB1993/001079 patent/WO1993024150A1/fr not_active IP Right Cessation
- 1993-05-25 JP JP6500317A patent/JPH08501064A/ja active Pending
- 1993-05-25 SG SG1996004921A patent/SG44645A1/en unknown
- 1993-05-25 DE DE4392401T patent/DE4392401T1/de active Pending
- 1993-05-25 NZ NZ252268A patent/NZ252268A/en not_active IP Right Cessation
- 1993-05-26 GR GR930100213A patent/GR1001550B/el not_active IP Right Cessation
- 1993-05-27 MC MC2243A patent/MC2330A1/fr unknown
- 1993-05-27 IT ITMI931099A patent/IT1271139B/it active IP Right Grant
- 1993-05-28 BE BE9300551A patent/BE1006143A3/fr not_active IP Right Cessation
- 1993-05-28 FR FR9306432A patent/FR2691631B1/fr not_active Expired - Fee Related
-
1994
- 1994-11-23 LU LU88559A patent/LU88559A1/fr unknown
- 1994-11-25 NO NO19944535A patent/NO311006B1/no unknown
- 1994-11-25 FI FI945553A patent/FI112603B/fi active
- 1994-11-28 SE SE9404115A patent/SE501970C2/sv unknown
- 1994-11-28 DK DK199401353A patent/DK176134B1/da not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/473,303 patent/US5889110A/en not_active Expired - Fee Related
-
1997
- 1997-06-26 HK HK133097A patent/HK133097A/xx not_active IP Right Cessation
-
1999
- 1999-01-22 US US09/235,270 patent/US6034175A/en not_active Expired - Fee Related
-
2001
- 2001-11-16 US US09/988,068 patent/US20020198315A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LU88559A1 (fr) | Sels de peptides comprenant des polyesters à terminaison carboxy | |
ITPD910047A0 (it) | Strumento per la legatura di emorroidi o simili | |
NO943761D0 (no) | Oralt administrerbare opioide formuleringer med forlenget effektvarighet | |
FI960584L (fi) | Terapeuttisia peptidijohdannaisia | |
DE69433571D1 (de) | Verkaufsstellensystem | |
FI940012L (fi) | Aryylisulfonamidosubstituoidut hydroksaamihapot | |
DE69402724D1 (de) | Führungsanlage | |
DE69424096D1 (de) | Bildprozessor | |
DE69419663D1 (de) | Multitasking-Prozessorarchitektur | |
EP0596729A3 (fr) | Afficheur d'image virtuelle pour tableau de bord. | |
DE69406011D1 (de) | Geschütztes bild | |
DE69424086D1 (de) | Bildprozessor | |
DK0925273T3 (da) | Farmaceutiske præparater indeholdende 4-oxo-butansyrer | |
MX9205378A (es) | Procedimiento para la esterificacion de sales de acidos carboxilicos. | |
ITMI922701A0 (it) | Costruzione modulare di navi mercantili | |
DE69427663D1 (de) | Bildprozessor | |
ITMI913464A0 (it) | Procedimento per la neutralizzazione di perfluoropolissialchileni | |
DE69323688D1 (de) | Epitop-Peptide von menschlichem Parvovirus | |
DE59410412D1 (de) | Bislactone | |
ATA114093A (de) | Markierte alpha aminosäuren | |
KR940022049U (ko) | 문자가 표시되는 향 | |
KR950013137U (ko) | 각도 변형 칫솔 | |
ITVR930055A0 (it) | Struttura di espositore particolarmente per edicole | |
IT8822479A0 (it) | Sale di calcio biodisponibile e relative composizoni farmaceutiche. | |
ITRM940151A0 (it) | Impiego di esteruretani per la riconcia. |