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ES2107357A1 - Sales de peptidos con poliesteres carboxi-terminados. - Google Patents

Sales de peptidos con poliesteres carboxi-terminados.

Info

Publication number
ES2107357A1
ES2107357A1 ES09450004A ES9450004A ES2107357A1 ES 2107357 A1 ES2107357 A1 ES 2107357A1 ES 09450004 A ES09450004 A ES 09450004A ES 9450004 A ES9450004 A ES 9450004A ES 2107357 A1 ES2107357 A1 ES 2107357A1
Authority
ES
Spain
Prior art keywords
salts
carboxy
peptides
excess
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09450004A
Other languages
English (en)
Other versions
ES2107357B1 (es
Inventor
Francis Gowland Hutchinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of ES2107357A1 publication Critical patent/ES2107357A1/es
Application granted granted Critical
Publication of ES2107357B1 publication Critical patent/ES2107357B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

SALES DE PEPTIDOS CON POLIESTERES CARBOXI-TERMINADOS, EN CONCRETO NUEVAS SALES CONSTITUIDAS POR UN CATION DERIVADO DE UN PEPTIDO QUE CONTIENE AL MENOS UN GRUPO BASICO Y DE UN ANION DERIVADO DE UN POLIESTER CARBOXI-TERMINADO. LA INVENCION PROPORCIONA TAMBIEN PROCESOS PARA PREPARAR DICHAS SALES, ASI COMO EL USO DE ESTAS ULTIMAS EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS DE LIBERACION PROLONGADA. LAS SALES DE LA INVENCION POSEEN DIVERSAS PROPIEDADES UTILES EN LA FORMULACION DE COMPOSICIONES FARMACEUTICAS DE LIBERACION PROLONGADA, INDEPENDIENTEMENTE DE QUE LAS SALES SE ENCUENTREN EN FORMA PURA O EN MEZCLA CON UN EXCESO DEL PEPTIDO EN SU FORMA LIBRE NO ENLAZADA O CON UN EXCESO DEL POLIESTER LIBRE.
ES09450004A 1992-05-28 1993-05-25 Sales de peptidos con poliesteres carboxi-terminados. Expired - Fee Related ES2107357B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB@@@@A GB9211268D0 (en) 1992-05-28 1992-05-28 Salts of basic peptides with carboxyterminated polyesters

Publications (2)

Publication Number Publication Date
ES2107357A1 true ES2107357A1 (es) 1997-11-16
ES2107357B1 ES2107357B1 (es) 1998-10-16

Family

ID=10716132

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09450004A Expired - Fee Related ES2107357B1 (es) 1992-05-28 1993-05-25 Sales de peptidos con poliesteres carboxi-terminados.

Country Status (33)

Country Link
US (3) US5889110A (es)
JP (1) JPH08501064A (es)
KR (1) KR100293882B1 (es)
AT (1) AT407702B (es)
AU (1) AU682310B2 (es)
BE (1) BE1006143A3 (es)
CA (1) CA2136751C (es)
CH (2) CH690491A5 (es)
CZ (1) CZ292449B6 (es)
DE (2) DE4392401B4 (es)
DK (1) DK176134B1 (es)
ES (1) ES2107357B1 (es)
FI (1) FI112603B (es)
FR (1) FR2691631B1 (es)
GB (3) GB9211268D0 (es)
GR (1) GR1001550B (es)
HK (1) HK133097A (es)
HU (1) HUT70177A (es)
IE (1) IE74715B1 (es)
IL (1) IL105710A (es)
IT (1) IT1271139B (es)
LU (1) LU88559A1 (es)
MC (1) MC2330A1 (es)
NL (1) NL195056C (es)
NO (1) NO311006B1 (es)
NZ (1) NZ252268A (es)
RU (1) RU2152225C1 (es)
SE (1) SE501970C2 (es)
SG (1) SG44645A1 (es)
SK (1) SK280320B6 (es)
TW (1) TW223018B (es)
WO (1) WO1993024150A1 (es)
ZA (1) ZA933358B (es)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
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US20020198315A1 (en) 2002-12-26
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