[go: up one dir, main page]

KR880000370A - 치환된 페닐화합물 - Google Patents

치환된 페닐화합물 Download PDF

Info

Publication number
KR880000370A
KR880000370A KR1019870006644A KR870006644A KR880000370A KR 880000370 A KR880000370 A KR 880000370A KR 1019870006644 A KR1019870006644 A KR 1019870006644A KR 870006644 A KR870006644 A KR 870006644A KR 880000370 A KR880000370 A KR 880000370A
Authority
KR
South Korea
Prior art keywords
butylphenol
integer
hexynoyl
group
inflammatory compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019870006644A
Other languages
English (en)
Other versions
KR960001695B1 (ko
Inventor
에드워드 루맨스 모리스
스트리커 메테우스 랜댈
아더 밀러 요셉
Original Assignee
원본미기재
더 프록터 앤드 갬블 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 더 프록터 앤드 갬블 캄파니 filed Critical 원본미기재
Publication of KR880000370A publication Critical patent/KR880000370A/ko
Application granted granted Critical
Publication of KR960001695B1 publication Critical patent/KR960001695B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/40—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
    • C07C15/42—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic
    • C07C15/48—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic the hydrocarbon substituent containing a carbon-to-carbon triple bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

내용 없음

Description

치환된 페닐화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 다음 일반식을 갖는 항염중 화합물 또는 그들의 약학적으로 허용되는 염.
    상기식에서
    (a) A1은 -OH,-H, 및 -O2CR로 이루어진 그룹중에서 선택되며, 여기서 R은 1 내지 약 10개의 탄소원자를 갖는 직쇄 또는 측쇄 알킬 그룹이며 :
    (b) A2는 Si(CH3)3탄소원자 1 내지 약 6 개의 비치환 또는 치환된 포화 또는 불포화된 직쇄 또는 측쇄 알킬그룹이며, 여기서 A2의 치환체는 할로, -OR3,-O2CR3, -CO2R3및 -C(O)R3중의 하나 또는 그 이상일 수 있고 :
    (c) A3는 -C(CH3)3, -Si(CH3)3및 -CF3로부터 선택되며,
    (d) Y는 다음 1) 내지 13)으로부터 선택되는데 :
    1) -(CR2 1)n-C≡C-H, 여기서 n은 1 내지 약 6 의 정수 :
    2)-(CR2 2)n-C≡C-H, 여기서 n은 0 내지 약 5 의 정수 :
    3) -(CR2 1)m -(CR2 1)n-C≡C-H, 여기서 m은 1 내지 약 5 의 정수이고 m+n은 1 내지 5 의 정수
    4) -CR1=CR1 (CR2 1)n-C≡C-H, 여기서 n은 0 또는 1 :
    5) -(CR2 1)n-CR3=CH2, 여기서 n은 2 내지 약 6 의 정수 :
    6)(CR2 1)n-CR3=CH2, 여기서 n은 0 내지 약 5 의 정수 :
    7) -(CR2 1)m (CR2 1)n-CR3=CH2, 여기서 m은 1 내지 약 3 의 정수, m+n은 1 내지 3 의 정수
    8) -CR1=CR1 (CR2 1)n-CR3=CH2, 여기서 n은 0 내지 약 3 의 정수
    9) -(CR2 1)n-CR3=C=CH2, 여기서 n은 0 내지 약 6 의 정수 :
    10) -(CR2 1)m (CR2 1)nCR3=C=CH2, 여기서 m+n은 0 내지 약 5 의 정수 :
    11) -CR1=CR1 (CR2 1)n-CR3=C=CH2, 여기서 n은 0 내지 약 3 의 정수 :
    12) -(CR2 1)n-CH(ZR4)2, 여기서 n은 1 내지 약 6 의 정수 :
    13) -(CR2 1)m (CR2 1)n-CH(ZR4)2, 여기서 n은 1 내지 약 5 의 정수, m은 0 에서 약 4 의 정수, m+n은 약 1 내지 약 5 의 정수 : 여기서 각 R1은 독립적으로 -H, -OR3, -NR2 3, -NR3 3+, -N(R3C(O)R|3, -O2CR3, -CO2R3, C(O)NR2 3, 1 내지 약 3개 탄소원자를 가지는 직쇄 또는 측쇄 알킬 그룹 및 1 내지 약 3개 탄소원자를 가지는 직쇄 또는 측쇄 비포화알킬 그룹중에서 선택되거나, 같은 탄소원자위의 두개의 R1=0 이며 : 각 R2는 독립적으로 -H, -OR3, -NR2 3, -NR3 3+, -N(R3)C(N)R3, -O2CR3, -CO2R3, C(O)NR2 3, 탄소원자 1 내지 약 3 의 직쇄 또는 측쇄 포화알킬 및 탄소원자 1 내지 약 2의 직쇄 또는 측쇄 비포화 알킬그룹 중에서 선택되거나, 또는 같은 탄소원자 위의 2개의 R2는 0 이고 : 각 R3는 독립적으로 -CH3및 -CH2CH|3에서 선택되거나, 또는 R4는 결합하여 사이클릭 아세탈은 형성할 수 있어서 결국 두개 R4는 함께 -(CH2)2및 -(CH2)3에서 선택되는 하나의 그룹이며 : 각 Z 는 독립적으로 O,S,NH 및 NR4중에서 선택된다.
  2. 제 1 항에 있어서, A2및 A3가 독립적으로 -C(CH3)3, -Si(CH|3) 및 CF3중에서 선택되는 항염증 화합물.
  3. 제 2 항에 있어서, A1이 OH 또는 H이고 : A2및 A3가 모두 -C(CH3)|3, -Si(CH3)3및 CF3중에서 선택되는 같은 그룹인 항염증 화합물.
  4. 제 3 항에 있어서, 다음 구조식을 가지는 항염증 화합물.
  5. 제 4 항에 있어서,
    (a) 각 R1및 R2가 독립적으로 -H,-OH,=CH2, 메칠 또는 에칠 중에서 선택되거나, 또는 같은 탄소원자 위의 2 개의 R1또는 R2가 0 이며 여기서 두개의 R1또는 R2그룹외의 다른 그룹은 -H가 아닌 그룹이고 :
    (b) 각 R3는 -H이며 :
    (c) 각 R4는 메칠이거나 R4그룹은 함께 사이클릭아세탈을 형성하는 -(CH2)|2그룹이고 :
    (d) 각 Z 는 독립적으로 O 또는 S중에서 선택되는 항염증 화합물.
  6. 제 5 항에 있어서, Y가 아래 중에서 선택되는 그룹인 항염증 화합물 :
    1) -(CR2 1)n-C≡C-H, 여기서 n은 1 내지 약 6 의 정수 :
    2)(CR2 2)n-C≡CH, 여기서 n은 0 내지 약 5 의 정수 :
    3) -(CR2 1)2 (CR2 1)n-C≡CH, 여기서 m은 0 내지 약 3 의 정수 :
    4) -CR1=CR1-C-(CR2 1)n-C≡CH, 여기서 n은 0 또는 1 :
    5) -(CR2 1)n-CH(ZR4)2여기서 n은 1 내지 약 6 의 정수 :
    6) -(CR2 1)2 (CR2 1)n-CH(ZR4)2, 여기서 n은 1 내지 약 3 의 정수 :
  7. 제 6 항에 있어서, Y가 아래로 그룹으로부터 선택되는 항염증 화합물.
    1) -(CR2 1)2 (CR2')n-C≡CH, 여기서 n은 0 내지 약 3 의 정수 :
    2)(CR2 1)n-CH(ZR4)2여기서 n은 1 내지 약 5 의 정수 :
    3)(CR2 2)n-C≡CH, 여기서 n은 0 내지 약 5 의 정수 :
  8. 제 4 항에 있어서, 하기 일반식을 갖는 항염증 화합물.
    여기서 n은 0 내지 약 5 의 정수 :
  9. 제 8 항에 있어서, R2가 독립적으로 -H, -OH,=CH2, 메칠 또는 에칠로부터 선택되며 :여기서 두개의 R2그룹 외의 다른 그룹은 -H가 아닌 항염증 화합물.
  10. 제 8 항에 있어서, R2가 수소인 항염증 화합물.
  11. 하기 화합물중에서 선택되는 항염증 화합물 또는 그들의 약학적으로 허용된 염.
    4-프로피노일-2.6-디-t-부틸페놀 :
    4-(1'-하이드록시-2'-프로피닐)-2,6-디-t-부틸페놀 :
    4-(3'-부티노일)-2,6-디-t-부틸페놀 :
    4-부타디에노일-2,6-디-t-부틸페놀 :
    4-(4'-펜티노일)-2,6-디-t-부틸페놀 :
    4-(4'-펜테노일)-2,6-디-t-부틸페놀 :
    4-(2'-디메톡시메틸-4'-펜티노일)-2,6-디-t-부틸페놀 :
    4-(2',2'-디메틸-4'-펜티노일)-2,6-디-t-부틸페놀 :
    4-(3',3'-디메틸-4'-펜티노일)-2,6-디-t-부틸페놀 :
    4-(4'-펜틴-3'-오네)-2,6-디-t-부틸페놀 :
    4-(5'-헥시노일)-2,6-디-t-부틸페놀 :
    4-(5'-헥세노일)-2,6-디-t-부틸페놀 :
    4-(2'-메틸-5'-헥시노일)-2,6-디-t-부틸페놀 :
    4-(5'-헥시닐)-2,6-디-t-부틸페놀 :
    4-(1'-하이드록시-5'-헥시노일)-2,6-디-t-부틸페놀 :
    4-((S)-(-)-3'-메틸-5'-헥시노일)-2,6-디-t-부틸페놀 :
    4-((R)-(+)-3'-메틸-5'-헥시노일)-2,6-디-t-부틸페놀 :
    1-(5'-헥시노일)-3,5-디-t-부틸벤젠 :
    4-(5'-헥시노일)-2,6-비스-트리메틸실릴페놀 :
    1-(5'-헥시노일)-3,5-비스-트리메틸실릴벤젠 :
    1-(5'-헥시노일)-3,5-비스(트리플루오로메틸)벤젠 :
    4-(6'-헵티노일)-2,6-디-t-부틸페놀 :
    4-(6'-헵틴-3'-오네)-2,6-디-t-부틸페놀 :
    4-(4'-(2'-프로피닐)-6'-헵틴-3'-오네)-2,6-부틸페놀 :
    4-(7'-옥티노일)-2,6-디-t-부틸페놀 :
    4-((E)-1'-펜텐-4'-인-3'-오네)-2,6-디-t-부틸페놀 :
    4-((E)-1',6'-헵타디엔-3'-오네)-2,6-디-t-부틸페놀 :
    4-(3',3'-디메톡시프로피오닐)-2,6-디-t-부틸페놀 :
    4-(2'-(1",3"-디옥소올란)아세틸)-2,6-디-t-부틸페놀 :
    4-(3',3'-디에톡시프로피오닐)-2,6-디-t-부틸페놀 :
    4-(2'-(1",3"-옥사티올란)아세틸)-2,6-디-t-부틸페놀 :
    4-(2',2'-디메톡시에틸)-2,6-디-t-부틸페놀 :
    4-(5',5'-디메톡시-3'-펜타논)-2,6-디-t-부틸페놀 :
    4-(3',3'-디메틸-5'-헥시노일)-2,6-디-t-부틸페놀 :
  12. 제11항에 있어서 하기 화합물중에서 선택되는 항염증 화합물.
    4-(4-펜텐-3'-오네)-2,6-디-t-부틸페놀 :
    4-(5'-헥시노일)-2,6-디-t-부틸페놀 :
    4-(S)-(-)-3'-메틸-5'-헥시노일)-2,6-디-t-부틸페놀 :
    4-(R)-(+)-3'-메틸-5'-헥시노일)-2,6-디-t-부틸페놀 : 및
    4-(3',3'-디메톡시프로피오닐)-2,6-디-t-부틸페놀 :
  13. 항염증 화합물 4-(5'-헥시노일)-2,6-디-t-부틸페놀 또는 그의 약학적으로 허용되는 염.
  14. 제 1 항 내지 제13항중의 어느 하나의 화합물의 약학적으로 허용되는 담체를 함유하는 약학적 조성물.
  15. 제 1 항 내지 제13항중의 어느 하나의 항염증 화합물의 안전하고 유효한 양을 치료를 필요로 하는 사람 또는 동물에 투여함을 포함하는 염증질환을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870006644A 1986-06-27 1987-06-27 치환된 페닐 화합물 Expired - Fee Related KR960001695B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US879,863 1986-06-27
US06/879,863 US4708966A (en) 1986-06-27 1986-06-27 Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
US879863 1986-06-27

Publications (2)

Publication Number Publication Date
KR880000370A true KR880000370A (ko) 1988-03-25
KR960001695B1 KR960001695B1 (ko) 1996-02-03

Family

ID=25375036

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870006644A Expired - Fee Related KR960001695B1 (ko) 1986-06-27 1987-06-27 치환된 페닐 화합물

Country Status (12)

Country Link
US (1) US4708966A (ko)
EP (1) EP0251408B1 (ko)
JP (1) JP2515341B2 (ko)
KR (1) KR960001695B1 (ko)
AT (1) AT407248B (ko)
AU (1) AU612979B2 (ko)
CA (1) CA1296342C (ko)
DE (1) DE3769379D1 (ko)
IE (1) IE60587B1 (ko)
IL (2) IL102278A (ko)
NZ (1) NZ220880A (ko)
ZA (1) ZA874635B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040043692A (ko) * 2002-11-19 2004-05-24 박선규 배출구가 돌기되는 치약내장형 칫솔

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK49688A (da) * 1987-03-20 1988-09-21 Hoffmann La Roche Propiolophenonderivater
US5103037A (en) * 1987-04-06 1992-04-07 Riker Laboratories, Inc. Substituted di-t-butylphenols
US4954332A (en) * 1987-10-22 1990-09-04 The Procter & Gamble Company Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent
US4847071A (en) * 1987-10-22 1989-07-11 The Procter & Gamble Company Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent
ATE176396T1 (de) 1987-10-22 1999-02-15 Procter & Gamble Chelatbildner enthaltende lichtschutzmittel
US4847303A (en) * 1987-11-23 1989-07-11 The Procter & Gamble Company Tert-butylphenyl compounds useful as anti-inflammatory agents
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
IL88674A0 (en) * 1987-12-18 1989-07-31 Norwich Eaton Pharma Preparation of certain substituted aromatic compounds
US4982006A (en) * 1987-12-18 1991-01-01 Norwich Eaton Pharmaceuticals, Inc. Process for the preparation of certain substituted aromatic compounds
AU624366B2 (en) * 1988-03-02 1992-06-11 Terumo Kabushiki Kaisha Catechol compounds, process for their preparation and pharmaceutical preparation containing same
DE69008321T2 (de) * 1989-11-22 1994-09-29 Procter & Gamble Pharmazeutische Tebufelon-Zusammensetzungen.
US5189066A (en) * 1989-11-22 1993-02-23 The Procter & Gamble Company Pharmaceutical compositions of tebufelone
US5281623A (en) * 1990-08-27 1994-01-25 Eli Lilly And Company Method for treating inflammation
ZA916555B (en) * 1990-08-27 1993-04-28 Lilly Co Eli Method of treating inflammatory bowel disease
DE69119605D1 (de) * 1990-11-12 1996-06-20 Fileco Sa Antivirale verwendung einer in position-4 substituierten 2,6-di-t-butylphenolverbindung, besonders gegen herpes- und papillomaviren
US5126487A (en) * 1991-03-26 1992-06-30 The Procter & Gamble Company Process for the preparation of 2-alkyl-4-acyl-6-tert-butylphenol compounds
TW222591B (ko) 1991-08-30 1994-04-21 Procter & Gamble
US5280045A (en) * 1991-10-16 1994-01-18 The Procter & Gamble Company 4(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide compound useful as an anti-inflammatory agent
US5187175A (en) * 1992-03-06 1993-02-16 Warner-Lambert Company 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US5281420A (en) * 1992-05-19 1994-01-25 The Procter & Gamble Company Solid dispersion compositions of tebufelone
TW312688B (ko) * 1993-08-02 1997-08-11 Mitsubishi Chem Corp
US5476876A (en) * 1994-05-24 1995-12-19 The Procter & Gamble Company Di-tert-butylphenol compounds useful as anti-inflammatory agents
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents
US5684204A (en) * 1995-11-15 1997-11-04 The Procter & Gamble Company Sulfur containing di-tert-butylphenol compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US6218437B1 (en) 1996-09-30 2001-04-17 The Regents Of The University Of California Treatment and prevention of hepatic disorders
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
RU2149635C1 (ru) * 1998-02-27 2000-05-27 Пермская государственная медицинская академия Способ лечения аллергических дерматитов
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US7479507B2 (en) * 2003-01-14 2009-01-20 Adam Heller Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
US20050003024A1 (en) * 2003-03-04 2005-01-06 The Procter & Gamble Company Regulation of mammalian hair growth
GB0329379D0 (en) * 2003-12-19 2004-01-21 Johnson Matthey Plc Prostaglandin synthesis
US20070191368A1 (en) * 2004-03-23 2007-08-16 Bissett Donald L Inhibition of tissue damage to skin from radiation treatment therapy
US20050255059A1 (en) * 2004-05-10 2005-11-17 Oblong John E Personal care compositions and methods regulating mammalian hair growth
US20050255060A1 (en) * 2004-05-10 2005-11-17 Oblong John E Personal care compositions and methods regulating mammalian hair growth
US20060286046A1 (en) * 2005-01-05 2006-12-21 Haber C Andrew Skin care compositions
EP2671507A3 (en) 2005-04-28 2014-02-19 Proteus Digital Health, Inc. Pharma-informatics system
US20070203240A1 (en) * 2006-02-27 2007-08-30 The Procter & Gamble Company Personal care compositions and methods for regulating mammalian hair growth
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
MX2011011833A (es) 2009-05-06 2012-01-27 Lab Skin Care Inc Composiciones de administración dérmica que comprenden complejos de partículas de fosfato de calcio-agente activo y métodos para utilizar las mismas.
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US11826277B2 (en) 2015-12-24 2023-11-28 Jason Jit-sun Tan Customizable stoma insert
US11207205B2 (en) 2015-12-24 2021-12-28 Jason Jit-sun Tan Customisable stoma insert

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247240A (en) * 1962-01-05 1966-04-19 Geigy Ag J R Process for the preparation of carbonyl compounds containing a hindered phenol group
US3335164A (en) * 1963-11-12 1967-08-08 Hoechst Ag Esters of ketophenols
USRE27004E (en) * 1966-08-17 1970-12-15 Process for the preparation of carbonyl compounds containing a hindered phenol group
US3526668A (en) * 1967-10-02 1970-09-01 Exxon Research Engineering Co Allyl phenols
US3477991A (en) * 1968-06-05 1969-11-11 Exxon Research Engineering Co Alkenyl hindered phenol and a copolymer of an alkenyl phenol and a monoolefin
US3660505A (en) * 1969-08-27 1972-05-02 Exxon Research Engineering Co Hindered alkenyl phenols from quinone methide
US3714122A (en) * 1970-07-20 1973-01-30 Goodyear Tire & Rubber Antioxidants and age resistant polymeric compositions
JPS6039262B2 (ja) * 1977-05-11 1985-09-05 ウェルファイド株式会社 第３級ブチルフェノ−ル誘導体
US4172151A (en) * 1977-05-16 1979-10-23 Riker Laboratories, Inc. Anti-inflammatory method
US4130666A (en) * 1977-05-16 1978-12-19 Riker Laboratories, Inc. Anti-inflammatory method
US4431656A (en) * 1981-02-05 1984-02-14 Kanegafuchi Chemical Industry Company Limited 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient
US4440784A (en) * 1981-02-05 1984-04-03 Kanegafuchi Chemical Industry Company, Ltd. Anti-inflammatory, analgesic, and antipyretic pharmaceutical composition
SU1054342A1 (ru) * 1982-05-06 1983-11-15 Институт Химии Башкирского Филиала Ан Ссср Способ получени 2,6-ди-трет-бутил-4-алкенилфенолов
JPS6054315A (ja) * 1983-09-05 1985-03-28 Kanegafuchi Chem Ind Co Ltd 抗高脂血症剤
US4758586A (en) * 1985-02-01 1988-07-19 Usv Pharmaceutical Corp. Indolyl compounds and hyposensitivity use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040043692A (ko) * 2002-11-19 2004-05-24 박선규 배출구가 돌기되는 치약내장형 칫솔

Also Published As

Publication number Publication date
KR960001695B1 (ko) 1996-02-03
US4708966B1 (ko) 1991-03-12
JPS6360947A (ja) 1988-03-17
IL83037A (en) 1993-03-15
IE60587B1 (en) 1994-07-27
AT407248B (de) 2001-01-25
ZA874635B (en) 1989-02-22
JP2515341B2 (ja) 1996-07-10
ATA162587A (de) 2000-06-15
NZ220880A (en) 1990-10-26
AU7474187A (en) 1988-01-07
IE871703L (en) 1987-12-27
DE3769379D1 (de) 1991-05-23
IL83037A0 (en) 1987-12-20
US4708966A (en) 1987-11-24
EP0251408B1 (en) 1991-04-17
AU612979B2 (en) 1991-07-25
EP0251408A1 (en) 1988-01-07
IL102278A (en) 1994-10-21
CA1296342C (en) 1992-02-25

Similar Documents

Publication Publication Date Title
KR880000370A (ko) 치환된 페닐화합물
KR890012970A (ko) 테트라히드로 이소퀴놀린 유도체
KR890016046A (ko) 2-치환-4-치환-1,3-디옥솔란, 이의 합성 및 이의 용도
KR900018073A (ko) 피페라진 화합물
KR950002755A (ko) 워트마닌 및 그의 유사체에 의한 포스파티딜이노시톨 3-키나제의 억제
KR890012650A (ko) 5-리폭시게나제 억제성 4-(4-페닐-1-피페라지닐)페닐유도체
KR910015552A (ko) 항당뇨병성 활성을 가진 티아졸리딘 유도체, 그의 제조 방법 및 용도
KR910004580A (ko) 신규 화합물
FR2694295B1 (fr) Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FI102273B1 (fi) Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyttö
EA200000731A1 (ru) Альфа-аминоамидные производные, полезные в качестве анальгетических агентов
DE59005254D1 (de) 24-Homo-Vitamin-D-Derivate, Verfahren zu ihrer Herstellung; diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung als Arzneimittel.
KR930702318A (ko) 이속사졸 화합물, 그의 약제학적으로 허용되는 염 및 그의 의학적 용도
KR910016330A (ko) 엘라스타제 억제제로서 벤즈이소티아졸리논-1-디옥사이드 유도체 및 그 조성물과 용도
KR950014067A (ko) 아릴아미드유도체
KR950005917A (ko) 벤조디푸라논 화합물을 함유하는 조성물 및 그를 이용한 소수성 재료의 착색방법
KR890008063A (ko) 소염제로서 유용한 3급-부틸페닐 화합물
KR890006590A (ko) 4-아미노피리딘 유도체
KR920016089A (ko) 제i형 당뇨병의 치료방법
ES2087252T3 (es) Uso de derivados de dioxabiciclo(3.3.0)octano para la preparacion de un medicamento para inhibir el metabolismo del colesterol.
KR920017669A (ko) 갈륨 화합물
KR860008973A (ko) 2-피롤리돈 유도체
KR910004557A (ko) 2,4,6-치환 페놀 유도체
FR2748025B1 (fr) Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
KR890009901A (ko) 3-히드록시-2-(4-메톡시페닐)-5-(2-메틸아미노에틸)-2,3-디히드로-5h-1,5- 벤조티아제핀-4-온 유도체, 그의 제조 및 치료에의 이용

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20020116

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20030204

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20030204

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000