USRE27004E - Process for the preparation of carbonyl compounds containing a hindered phenol group - Google Patents

Process for the preparation of carbonyl compounds containing a hindered phenol group Download PDF

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Publication number: USRE27004E
Authority: US; United States
Prior art keywords: parts; preparation; tertiary butyl; alkyl; tertiary
Prior art date: 1966-08-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-08-17

Filing date

1966-08-17

Publication date

1970-12-15

1966-08-17 Application filed filed Critical

1970-12-15 Application granted granted Critical

1970-12-15 Publication of USRE27004E publication Critical patent/USRE27004E/en

Status Expired legal-status Critical Current

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238000000034 method Methods 0.000 title description 23
238000002360 preparation method Methods 0.000 title description 16
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title description 4
150000001728 carbonyl compounds Chemical class 0.000 title description 2
-1 docosyl tricosyl Chemical group 0.000 description 42
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 22
125000000217 alkyl group Chemical group 0.000 description 20
150000001875 compounds Chemical class 0.000 description 18
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 17
239000002904 solvent Substances 0.000 description 16
238000006243 chemical reaction Methods 0.000 description 14
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
229910052783 alkali metal Inorganic materials 0.000 description 11
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 11
DKCPKDPYUFEZCP-UHFFFAOYSA-N 2,6-di-tert-butylphenol Chemical compound CC(C)(C)C1=CC=CC(C(C)(C)C)=C1O DKCPKDPYUFEZCP-UHFFFAOYSA-N 0.000 description 10
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 10
239000000047 product Substances 0.000 description 10
125000004432 carbon atom Chemical group C* 0.000 description 9
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 8
239000002585 base Substances 0.000 description 8
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 7
239000003054 catalyst Substances 0.000 description 7
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 7
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 7
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 6
125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 description 6
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 6
125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
239000001257 hydrogen Substances 0.000 description 6
229910052739 hydrogen Inorganic materials 0.000 description 6
125000002463 lignoceryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000002960 margaryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
239000000284 extract Substances 0.000 description 5
125000000755 henicosyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 5
125000001196 nonadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 5
239000000376 reactant Substances 0.000 description 5
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 5
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 4
239000005977 Ethylene Substances 0.000 description 4
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 4
238000007792 addition Methods 0.000 description 4
150000008044 alkali metal hydroxides Chemical class 0.000 description 4
150000001340 alkali metals Chemical class 0.000 description 4
125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
239000011368 organic material Substances 0.000 description 4
229940080818 propionamide Drugs 0.000 description 4
239000011541 reaction mixture Substances 0.000 description 4
125000002469 tricosyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
125000003545 alkoxy group Chemical group 0.000 description 3
125000002947 alkylene group Chemical group 0.000 description 3
150000002431 hydrogen Chemical group 0.000 description 3
239000011261 inert gas Substances 0.000 description 3
238000002844 melting Methods 0.000 description 3
230000008018 melting Effects 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
239000003921 oil Substances 0.000 description 3
229960003742 phenol Drugs 0.000 description 3
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 3
239000003381 stabilizer Substances 0.000 description 3
GJYCVCVHRSWLNY-UHFFFAOYSA-N 2-butylphenol Chemical compound CCCCC1=CC=CC=C1O GJYCVCVHRSWLNY-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
150000001252 acrylic acid derivatives Chemical class 0.000 description 2
150000001336 alkenes Chemical class 0.000 description 2
125000005250 alkyl acrylate group Chemical group 0.000 description 2
150000001408 amides Chemical class 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
125000003710 aryl alkyl group Chemical group 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
SMTUJUHULKBTBS-UHFFFAOYSA-N benzyl(trimethyl)azanium;methanolate Chemical compound [O-]C.C[N+](C)(C)CC1=CC=CC=C1 SMTUJUHULKBTBS-UHFFFAOYSA-N 0.000 description 2
238000009835 boiling Methods 0.000 description 2
239000012043 crude product Substances 0.000 description 2
239000002274 desiccant Substances 0.000 description 2
125000004663 dialkyl amino group Chemical group 0.000 description 2
125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
238000001914 filtration Methods 0.000 description 2
239000000295 fuel oil Substances 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
150000002430 hydrocarbons Chemical class 0.000 description 2
239000010687 lubricating oil Substances 0.000 description 2
QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 2
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
150000002894 organic compounds Chemical class 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
239000003208 petroleum Substances 0.000 description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
125000001453 quaternary ammonium group Chemical group 0.000 description 2
238000010992 reflux Methods 0.000 description 2
239000002002 slurry Substances 0.000 description 2
ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
BSYJHYLAMMJNRC-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-ol Chemical compound CC(C)(C)CC(C)(C)O BSYJHYLAMMJNRC-UHFFFAOYSA-N 0.000 description 1
WFRBDWRZVBPBDO-UHFFFAOYSA-N 2-methyl-2-pentanol Chemical compound CCCC(C)(C)O WFRBDWRZVBPBDO-UHFFFAOYSA-N 0.000 description 1
DWTBZBLLDLEJMV-UHFFFAOYSA-N 2-methyl-6-(2,4,4-trimethylpentan-2-yl)phenol Chemical compound CC1=CC=CC(C(C)(C)CC(C)(C)C)=C1O DWTBZBLLDLEJMV-UHFFFAOYSA-N 0.000 description 1
MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 1
KRIMXCDMVRMCTC-UHFFFAOYSA-N 2-methylhexan-2-ol Chemical compound CCCCC(C)(C)O KRIMXCDMVRMCTC-UHFFFAOYSA-N 0.000 description 1
SDTMFDGELKWGFT-UHFFFAOYSA-N 2-methylpropan-2-olate Chemical compound CC(C)(C)[O-] SDTMFDGELKWGFT-UHFFFAOYSA-N 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
PXMJCECEFTYEKE-UHFFFAOYSA-N Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester Chemical compound COC(=O)CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 PXMJCECEFTYEKE-UHFFFAOYSA-N 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
IEPRKVQEAMIZSS-UHFFFAOYSA-N Di-Et ester-Fumaric acid Natural products CCOC(=O)C=CC(=O)OCC IEPRKVQEAMIZSS-UHFFFAOYSA-N 0.000 description 1
IEPRKVQEAMIZSS-WAYWQWQTSA-N Diethyl maleate Chemical compound CCOC(=O)\C=C/C(=O)OCC IEPRKVQEAMIZSS-WAYWQWQTSA-N 0.000 description 1
OWYWGLHRNBIFJP-UHFFFAOYSA-N Ipazine Chemical compound CCN(CC)C1=NC(Cl)=NC(NC(C)C)=N1 OWYWGLHRNBIFJP-UHFFFAOYSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
150000004703 alkoxides Chemical class 0.000 description 1
125000003282 alkyl amino group Chemical group 0.000 description 1
125000002877 alkyl aryl group Chemical group 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
125000005037 alkyl phenyl group Chemical group 0.000 description 1
230000029936 alkylation Effects 0.000 description 1
238000005804 alkylation reaction Methods 0.000 description 1
230000009435 amidation Effects 0.000 description 1
238000007112 amidation reaction Methods 0.000 description 1
125000005122 aminoalkylamino group Chemical group 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000001311 chemical methods and process Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 description 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
239000003502 gasoline Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
JHXWQHBXAJJDSQ-UHFFFAOYSA-N henicos-1-en-3-one Chemical compound CCCCCCCCCCCCCCCCCCC(=O)C=C JHXWQHBXAJJDSQ-UHFFFAOYSA-N 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
PBOSTUDLECTMNL-UHFFFAOYSA-N lauryl acrylate Chemical compound CCCCCCCCCCCCOC(=O)C=C PBOSTUDLECTMNL-UHFFFAOYSA-N 0.000 description 1
230000001050 lubricating effect Effects 0.000 description 1
150000002688 maleic acid derivatives Chemical class 0.000 description 1
239000000463 material Substances 0.000 description 1
239000000155 melt Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
CNWVYEGPPMQTKA-UHFFFAOYSA-N n-octadecylprop-2-enamide Chemical compound CCCCCCCCCCCCCCCCCCNC(=O)C=C CNWVYEGPPMQTKA-UHFFFAOYSA-N 0.000 description 1
229920003052 natural elastomer Polymers 0.000 description 1
229920001194 natural rubber Polymers 0.000 description 1
FSAJWMJJORKPKS-UHFFFAOYSA-N octadecyl prop-2-enoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)C=C FSAJWMJJORKPKS-UHFFFAOYSA-N 0.000 description 1
229960005235 piperonyl butoxide Drugs 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000010802 sludge Substances 0.000 description 1
239000000344 soap Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
150000003890 succinate salts Chemical class 0.000 description 1
229920003051 synthetic elastomer Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
239000005061 synthetic rubber Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
LGQXXHMEBUOXRP-UHFFFAOYSA-N tributyl borate Chemical compound CCCCOB(OCCCC)OCCCC LGQXXHMEBUOXRP-UHFFFAOYSA-N 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
- C09K15/06—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen
- C09K15/08—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen containing a phenol or quinone moiety
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds

Definitions

This invention relates to a novel and useful process for the preparation of certain 3,S-dialkyl-4-hydroxyphenyl organic compounds.
the invention concerns the preparation of compounds of the Formula I:
R is a secondary or a tertiary alkyl group, preferably the tertiary (t or tert.) butyl group; other groups possible are, e.g., the isopropyl group, secondary (sec) or tert.
alkyl groups of 4 to 24 carbon atoms butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl tricosyl, tetracosyl, etc.,
R is an alkyl group, preferably the tertiary butyl group
alkyl groups of 1 to 24 carbon atoms methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl, tricosyl, tetracosyl, etc.
R and R are each independently hydrogen, alkyl
aryl-especially phenyl, acenaphthyl and naphthylalkaryL-especially alkylphenyl and polyalkylphenyl aralkylespecially benzyland carbalkoxy and R is alkoxy, alkyl thioalkyloxy or alkyloxyalkyloxy amino alkylamino, dialkylamino, alkyl, arylespecially phenyl, acenaphthyl or naphthylalkylaryl, arylalkyl, hydrogen and the group wherein Z is a straight or branched alkylene group, and
R R R R and R have the means described hereinabove.
the 3,5-dialkyl-4-hydroxyphenyl substituted organic compounds of the Formula I are used as stabilizers for organic material normally subject to deterioration caused by heat, light, oxygen, ozone, and other physical and/or chemical forces tending to cause degradation, embrittlement, gum or sludge formation, discoloration and other undesirable effects in a variety of organic materials, e.g., lubricating oils and fuel oils, and in general, oils of mineral, vegetable or animal origin, waxes, soaps, greases, gasoline, natural and synthetic rubbers, resins, and
plastics such as polymers of hydrocarbons, e.g. ethylene and propylene, etc.
An object of this invention is to provide a novel chemical process for preparing the compounds of the Formula I.
a further object is to provide a process which comprises contacting a 3,5-dialkyl-4-hydroxybenzene compound, suitable to yield a derivative of the Formula I above, with an appropriate compound of the Formula III (hereinbelow) in the presence of a base catalyst and a solvent, such as a difficulty esterifiable alcohol, to yield the desired organic compound of the Formula I.
the difficulty esterifiable alcohol is preferably a lower alkanol, especially a tertiary lower alkanol e.g.
a base catalyst such as a quaternary ammonium base, e.g. benzyltrimethylammonium methoxide or such as alkali metal amides, e.g., sodamide, or alkali metal alkoxidespreferably an alkali metal lower alkoxide, e.g., sodium or potassium methoxide, ethoxide, n-propoxide, isopropoxide, n-butoxide, sec.-butoxide, t-butoxide, pentoxide, hexoxide, heptoxide, octyloxide, etc., or alkali metal hydroxides, e.g., sodium or potassium hydroxide.
the alkaline earth metal alkoxides or hydroxides are also useful.
a suitable solvent which can be either one of the reacting Compounds II or III which may or may not be present in equimolar amounts, or an auxiliary solvent which may be an aliphatic alcohol, preferably a difficulty esterifiable alcohol such as a tertiary alkanol, e.g., tertiary butanol, or an ether type solvent such as tetrahydrofuran, or a suitable amide such as dimethyl formamide, or a suitable ketone, such as acetone.
a suitable solvent which can be either one of the reacting Compounds II or III which may or may not be present in equimolar amounts
an auxiliary solvent which may be an aliphatic alcohol, preferably a difficulty esterifiable alcohol such as a tertiary alkanol, e.g., tertiary butanol, or an ether type solvent such as tetrahydrofuran, or a suitable amide such as dimethyl form
Compounds of the Formula III are prepared by suitable esterification and amidation of sutiable acrylic acid derivatives, methacrylic acid derivatives and other suitable substituted acrylic acid derivatives. Compounds of the Formula III are also available in some cases commercially.
a wide range of temperatures from 25 C. (at atmospheric pressure) to 200 C. (at elevated pressures) may be employed to bring about the desired addition.
the preferred range of temperatures is 40 to 110 C.
the reaction may be conducted at 1:1 molar concentrations of the two reactants II and III. Large excesses of the activated olefin III should be avoided in order to prevent side reactions.
catalyst concentrations e.g., from 0.01 to 100 mole percent, based on the phenol (II) concentration, may be employed, though preferred are mole percents of 5 to 25%.
any suitable mode of addition may be employed although it has been found most practical to add the activated olefin in III last to prevent its homopolymerization particularly at elevated temperatures.
Optimum results are obtained when air or oxygen is excluded or substantially reduced in amount from the atmosphere immediately in contact with the reactants. This can be accomplished in various ways, e.g., by
a reaction vessel is chosen whereby the reactants, solvent, catalyst, etc. substantially fill the vessel.
air may be swept out with an inert gas such as nitrogen before introducing the reactants, etc, into the reaction vessel.
Preferred products produced according to the process of the invention are compounds of the Formula 1(a):
R R is alkoxy-especially alkoxy having 1 to 24 carbon atoms, e.g., methoxy, ethoxy, propoxy, butoxy, pentoxy. hexoxy, heptoxy, octyloxy, nonyloxy, decyloxy,
undecyloxy dodecyloxy, tridecyloxy, tetradecloxy, pentadecyloxy, hexadecyloxy, heptadecyloxy, octadecyloxy. nonadecyloxy, eicosyloxy, heneicosyloxy,
A is a straight or branched chain alkylene group, particularly an alkylcne group having 1 to 6 carbon atoms, most particularly the ethylene group,
R R R and R are defined the same as hereinabove.
the compounds of the Formula I(a) are preferably produced by the process which comprises reacting a li IIO g wherein R R R and R are defined as herein above, and R is an alkyl group, especially an alkyl group having 1 to 24 carbon atoms therein as illustrated in Example VII hereinbelow,
stabilizers for unstable organic material e.g., hydrocarbon oils, lubricating and fuel oils, plastic materials such as polypropylene and polyethylene, etc. as described hereinabove.
R and R are each independently hydrogen or carbalkoxy, especially lower carbalkoxy, e.g., carbomethoxy, carboethoxy, carbopropoxy, carbobutoxy, carbopentoxy, carbohexoxy; the most preferred embodiments of R and R being those wherein one of R and R is lower carbalkoxy and the other is hydrogen, and
R is an alkyl group, e.g., an alkyl group of l to 24 carbon atoms, preferably a lower alkyl group, i.e., methyl, ethyl, propyl, butyl, pentyl, hexyl.
Example I Preparation of methyl fl (3,5-di-tertiary buty1-4-hydroxyphenyl)propionate via potassium metal
a suitable flask fitted with mechanical stirrer, inert gas inlet, thermometer, condenser and dropping funnel
2.1 parts of potassium metal is added to 500 parts by volume of dry tertiary butyl alcohol contained in a suitable flask (fitted with mechanical stirrer, inert gas inlet, thermometer, condenser and dropping funnel)
2.1 parts of potassium metal After the ensuing reaction is complete there is added 37.3 parts of 2.6-di-tertiary butyl phenol followed by 17.7 parts of mcthylacrylate rapidly in that order.
the stirred reaction mixture is heated to for 18 hours and allowed to cool.
the corresponding alkyl esters are obtained from the respective alkyl acrylates: ethyl, propyl, butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl, tricosyl, tetracosyl, etc.
Example I If in Example I there is substituted for potassium tertiary butoxide catalyst either benzyltrimethylammonium methoxide or sodamide, then the desired product is obtained.
Example II Preparation of methyl B-(3,5-di-tertiary butyl-4-hydroxyphenyl)propionate via potassium hydroxide
the reaction conditions are the same as those employed in Example I with the exception that a slurry of 3.5 parts of potassium hydroxide in 500 parts by volume of tertiary butyl alcohol is used in the place of potassium (as the alcoholate) as the base catalyst.
a somewhat lower yield of the product ester is realized by this method.
Example III Preparation of dodecyl fl-(3,5-di-tertiarybutyl-4-hydroxyphenyl propionate
a tertiary butyl alcohol containing 2.2 parts of potassium metal.
Upon completion of the ensuing reaction there is added 44.6 parts of 2,6- ditertiary butyl phenol and 57.9 parts of lauryl acrylate in rapid succession.
the resulting system is heated to reflux for six hours and then allowed to cool.
the solvent is then removed under reduced pressure and the residual mass neutralized with very dilute hydrochloric acid.
the reaction mixture is extracted two times with 300 parts by volume portions of 1:1 ethyl ether: petroleum ether and the combined extracts with two 100 parts by volume portions of water.
the extract is then dried over anhydrous sodium sulfate, the drying agent filtered off, and the ethereal solution concentrated to a final temperature of 200 at a pressure of 0.1 mm. Hg.
the product, dodecy] fi-(3,5-di-tertiary butyl-4-hydroxyphenyl) propionate, a viscous residue is analyzed.
Example IV Preparation of diethyl a-(3,5-di-tertiary butyl-4-h ydroxyphenyl) succinate
tertiary butyl alcohol 2.1 parts of potassium metal.
45.9 parts of 2,6-di-tertiary butyl phenol followed by 41.7 parts of diethyl maleate are rapidly added.
the resulting system is refluxed for 20 hours and then allowed to cool.
the reaction mixture is concentrated under reduced pressure to remove most of the solvent and then neutralized with diluted hydrochloric acid.
the resulting mass is then extracted with two times 200 parts by volume portions of ether and the combined ethereal solutions with two times 100 parts by volume portions of water.
the ethereal solution is then dried over anhydrous sodium sulfate and then concentrated on the steam bath.
the residual oil is distilled collecting the 6 fraction boiling from 164-174 under 0.1 mm. Hg pressure.
dialkyl succinate derivatives are obtained: methyl, propyl, butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, dOcosyl, tricosyl, tetracosyl, etc.
Example V Preparation of fi-(3.5-di-tertiary butyl4- hydroxyphenyl)propionamide
a solution prepared by reaction 2.0 parts of potassium metal with 500 parts by volume of dry tertiary butanol is added 21 parts of acrylamide followed by 38.2 parts of 2,6-di-tertiary butyl phenol.
the resulting system is refluxed for 24 hours and allowed to cool.
the excess solvent is removed under reduced pressure and the residue neutralized with diluted hydrochloric acid.
the mass is then extracted with two times 200 parts by volume of ether and the C mbined ethereal extracts with copious amounts of water.
the ethereal layer is then dried over anhydrous sodium sulfate and concentrated on the steam bath.
N,N-dialkylacrylamides are employed to yield the corresponding N,N-dialkyl propionamide derivatives: ethyl, propyl, butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonodecyl, eicosyl, heneicosyl, docosyl, tricosy], tetracosyl, etc.
N-nonoalkyl amides of 1 to 24 carbon atoms in the alkyl group are prepared from the corresponding N-alkylacrylamide.
alkyl groups are the same as for the N,N-dialkylacrylamides above. See, for example, Example VIII.
Example VI Preparation of n-octadecyl B-(3,5-ditertiary butyl-4-hydroxyphenyl )propionate
a solution prepared by adding 2.0 parts of potassium metal to 500 parts by volume of dry tertiary butyl alcohol and allowing the reaction to go to completion is added 365 parts of 2,6-di-tertiary butyl phenol followed by a slurry of 58.4 parts of octadecyl acrylate in 350 parts by volume of tertiary butyl alcohol.
the resulting system which becomes homogeneous on heating is maintained at reflux for 48 hours.
the solvent is removed under reduced pressure and the residual mass is neutralized with very dilute hydrochloric acid.
Example VlI.-Preparation of 4-(3'5di-tertiary butyl-4'-hydroxyphenyl)butan-lone To a solution prepared by reacting 1.2 parts of potassium metal with 250 parts by volume of tertiary butyl alcohol is added 46.6 parts of 2,6 di tertiary butyl phenol. To this stirred solution is added dropwise 26.8 parts of methyl vinyl ketone at such a rate as to keep the temperature below 65. After addition is complete the reaction mass is heated at 50 for 16 hours and then allowed to cool to room temperature. The excess methyl vinyl ketone and solvent are distilled off under reduced pressure. The residue is neutralized with very dilute hydrochloric acid and extracted with two times 200 parts by volume portions of ether.
Example VII If in the preceding Example VII. 109 parts of octadecyl vinyl ketone are substituted for 268 parts of methyl vinyl ketone, then there is obtained 5-(3,5-di-tertiary butyl4-hydroxyphenyll-ethyl octadecyl ketone.
Other i substituted ethyl alkyl ketones are prepared in a similar way when the respective alkyl vinyl ketone is employed: ethyl, propyl, butyl. amyl. hexyl, heptyl, octyl, nonyl, decyl. undecyl, dodecyl. tridecyl.
the drying agent is removed via filtration and the ethereal solution evaporated to dryness on the steam bath.
the resultant solid mass is recrystallized from ethanol-water mixtures to yield the desired compound, ethylene bis-I'B-(B'j-di-tertiary butyl 4 hydroxy phenyl)pr0pionate], M.P. l45.5-147 (uncorrected).
To 169.5 parts of molten 2,6-di-tertiary butyl phenol under nitrogen in a similar apparatus as described in Example l is rapidly added 4.9 parts of sodium methylate.
To the stirred system is added dropwise 78.8 parts of methyl acrylate over a 20 minute period. After the exothermic reaction subsides the reaction mixture is heated for an additional 3 hours at The product, methyl ,3 (3,5 di tertiary butyl-4-hydroxypheny])propionate, is isolated and purified in the fashion described in Example I, said product after crystallization, melting at 6364.5.
R is a member selected from the group consisting of secondary alkyl and tertiary alkyl
R is alkyl each of R and R is a member selected from the group consisting of hydrogen, alkyl, aryl, alkaryl, aralkyl and carbalkoxy, and
R is a member selected from the group consisting of alkoxy, amino, alkylamino, dialkylamino, alkyl, hydrogen and the group R l l in which Z is alkylene and R R R and R are as above defined, which comprises treating a compound of the formula:
amnion-icon alkyl l can tr:
1ro-- crncinooo alky the steps which comprise treating 2,6-di-t-butylphenol with about an equivalent amount of an alkyl acrylate in the presence of from about .05 to about .25 molar equivalent of an alkali metal base or a quaternary ammonium lmsc and at a temperature of from about 40 C. to about 4.
the alkali A metal base is an alkali metal hydroxide.

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Description

United States Patent 27,004 PROCESS FOR THE PREPARATION OF CARBONYL COMPOUNDS CONTAINING A HINDERED PHENOL GROUP Eric A. Meier, North Brunswick, N.J., and Martin Dexter,

Briarclitf Manor, N.Y., assignors to Geigy Chemical Corporation, Greenburgh, N.Y., a corporation of Delaware No Drawing. Original No. 3,247,240, dated Apr. 19, 1966,

Ser. No. 164,619, Jan. 5, 1962. Application for reissue Aug. 17, 1966, Ser. No. 576,173

The portion of the term of the patent subsequent to Feb. 18, 1981, has been disclaimed Int. Cl. C07c 39/02, 69/76, 103/26 U.S. Cl. 260473 14 Claims Matter enclosed in heavy brackets appears in the original patent but forms no part of this reissue specification; matter printed in italics indicates the additions made by reissue.

This invention relates to a novel and useful process for the preparation of certain 3,S-dialkyl-4-hydroxyphenyl organic compounds. In particular, the invention concerns the preparation of compounds of the Formula I:

wherein R is a secondary or a tertiary alkyl group, preferably the tertiary (t or tert.) butyl group; other groups possible are, e.g., the isopropyl group, secondary (sec) or tert. alkyl groups of 4 to 24 carbon atoms: butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl tricosyl, tetracosyl, etc.,

R is an alkyl group, preferably the tertiary butyl group;

other groups possible are alkyl groups of 1 to 24 carbon atoms: methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl, tricosyl, tetracosyl, etc.

R and R are each independently hydrogen, alkyl,

aryl-especially phenyl, acenaphthyl and naphthylalkaryL-especially alkylphenyl and polyalkylphenyl aralkylespecially benzyland carbalkoxy and R is alkoxy, alkyl thioalkyloxy or alkyloxyalkyloxy amino alkylamino, dialkylamino, alkyl, arylespecially phenyl, acenaphthyl or naphthylalkylaryl, arylalkyl, hydrogen and the group wherein Z is a straight or branched alkylene group, and

R R R and R have the means described hereinabove.

The 3,5-dialkyl-4-hydroxyphenyl substituted organic compounds of the Formula I are used as stabilizers for organic material normally subject to deterioration caused by heat, light, oxygen, ozone, and other physical and/or chemical forces tending to cause degradation, embrittlement, gum or sludge formation, discoloration and other undesirable effects in a variety of organic materials, e.g., lubricating oils and fuel oils, and in general, oils of mineral, vegetable or animal origin, waxes, soaps, greases, gasoline, natural and synthetic rubbers, resins, and

Re. 27,004 Reissued Dec. 15, 1970 Fee plastics, such as polymers of hydrocarbons, e.g. ethylene and propylene, etc.

An object of this invention is to provide a novel chemical process for preparing the compounds of the Formula I. A further object is to provide a process which comprises contacting a 3,5-dialkyl-4-hydroxybenzene compound, suitable to yield a derivative of the Formula I above, with an appropriate compound of the Formula III (hereinbelow) in the presence of a base catalyst and a solvent, such as a difficulty esterifiable alcohol, to yield the desired organic compound of the Formula I. The difficulty esterifiable alcohol is preferably a lower alkanol, especially a tertiary lower alkanol e.g. t-butanol, t-pentanol, t-hexanol, t-heptanol, t-octanol. In this specification lower alkanols have up to 8 carbon atoms. Other objects of this invention will be apparent from the description and specification which follows.

It has now surprisingly been found that the foregoing objects of the invention are realized by the process which comprises reacting a compound of the Formula II:

R2 (ll) wherein R and R are defined as hereinabove, with a further compound of the Formula III:

CH=C-C 0R5 I i? R4 ([11) wherein R R and R are defined as above, the reaction to be carried out in the presence of a base catalyst such as a quaternary ammonium base, e.g. benzyltrimethylammonium methoxide or such as alkali metal amides, e.g., sodamide, or alkali metal alkoxidespreferably an alkali metal lower alkoxide, e.g., sodium or potassium methoxide, ethoxide, n-propoxide, isopropoxide, n-butoxide, sec.-butoxide, t-butoxide, pentoxide, hexoxide, heptoxide, octyloxide, etc., or alkali metal hydroxides, e.g., sodium or potassium hydroxide. The alkaline earth metal alkoxides or hydroxides are also useful.

The Compounds II and III and the base catalyst are reacted in a suitable solvent which can be either one of the reacting Compounds II or III which may or may not be present in equimolar amounts, or an auxiliary solvent which may be an aliphatic alcohol, preferably a difficulty esterifiable alcohol such as a tertiary alkanol, e.g., tertiary butanol, or an ether type solvent such as tetrahydrofuran, or a suitable amide such as dimethyl formamide, or a suitable ketone, such as acetone.

Compounds of the Formula II are prepared by alkylation of phenol and by other known methods. Certain compounds of the Formula II are available commercially, e.g. 2,6-di-tert.-butylphenol. Examples of the compounds of the Formula II which are useful are the following:

G-t-butyl-o-cresol, 6 (1,1,3,3-tetromethylbutyl)o-cresol, 2-sec-butyl-lS-t-butylphenol,

2,6-bis( l ,l-dimethyl-n-propyl phenol 2,6-bis( l-methyl-n-nonyl phenol, 2-(1,1,3,3-tetramethyl-n-butyl)-6-methylphenol, etc.

Compounds of the Formula III are prepared by suitable esterification and amidation of sutiable acrylic acid derivatives, methacrylic acid derivatives and other suitable substituted acrylic acid derivatives. Compounds of the Formula III are also available in some cases commercially.

A wide range of temperatures from 25 C. (at atmospheric pressure) to 200 C. (at elevated pressures) may be employed to bring about the desired addition. The preferred range of temperatures is 40 to 110 C.

The reaction may be conducted at 1:1 molar concentrations of the two reactants II and III. Large excesses of the activated olefin III should be avoided in order to prevent side reactions.

Any suitable catalyst concentrations, e.g., from 0.01 to 100 mole percent, based on the phenol (II) concentration, may be employed, though preferred are mole percents of 5 to 25%.

Any suitable mode of addition may be employed although it has been found most practical to add the activated olefin in III last to prevent its homopolymerization particularly at elevated temperatures.

Optimum results are obtained when air or oxygen is excluded or substantially reduced in amount from the atmosphere immediately in contact with the reactants. This can be accomplished in various ways, e.g., by

blanketing the reactants in the reaction vessel with an inert gas such as nitrogen. Alternatively, a reaction vessel is chosen whereby the reactants, solvent, catalyst, etc. substantially fill the vessel. In a reaction in a closed vessel. air may be swept out with an inert gas such as nitrogen before introducing the reactants, etc, into the reaction vessel.

Preferred products produced according to the process of the invention are compounds of the Formula 1(a):

Iln CH -(JII*CO' R l l i l R3 R4 R2 carbononadecyloxy, carboeicosyloxy, carboheneicosyloxy, carbodocosyloxy, carbotricosyloxy, carbotetra cosylxyhydrogen being preferred for R R is alkoxy-especially alkoxy having 1 to 24 carbon atoms, e.g., methoxy, ethoxy, propoxy, butoxy, pentoxy. hexoxy, heptoxy, octyloxy, nonyloxy, decyloxy,

undecyloxy, dodecyloxy, tridecyloxy, tetradecloxy, pentadecyloxy, hexadecyloxy, heptadecyloxy, octadecyloxy. nonadecyloxy, eicosyloxy, heneicosyloxy,

docosyloxy, tricosyloxy, tetracosyloxyamino, alkylamino-especially having 1 to 24 carbon atoms, e.g. methylamino, ethylamino, propylamino, butylamino, pentylamino, hexylamino, octylamino, nonylamino, decylamino, undecylamino, dodecylamino, tridecylamino, tetradecylamino, pentadecylamino, hexadccylamino, heptadecylamino, octadecylamino, nonadecylamino. eicosylamino, heneicosylamino, docosylamino, tricosylamino, tetracosylamino-and the group wherein A is a straight or branched chain alkylene group, particularly an alkylcne group having 1 to 6 carbon atoms, most particularly the ethylene group,

and R R R and R are defined the same as hereinabove.

The compounds of the Formula I(a) are preferably produced by the process which comprises reacting a li IIO g wherein R R R and R are defined as herein above, and R is an alkyl group, especially an alkyl group having 1 to 24 carbon atoms therein as illustrated in Example VII hereinbelow,

are useful stabilizers for unstable organic material, e.g., hydrocarbon oils, lubricating and fuel oils, plastic materials such as polypropylene and polyethylene, etc. as described hereinabove.

In a further aspect of this invention it has now been found that there are likewise useful as stabilizers for unstable organic material, e.g., mineral oils, polypropylene, etc.-as described hereinabove-the novel compounds of the Formula V:

R, no you Gll' CO Olt l R5 R9 wherein R and R are the same as defined hereinabove,

R and R are each independently hydrogen or carbalkoxy, especially lower carbalkoxy, e.g., carbomethoxy, carboethoxy, carbopropoxy, carbobutoxy, carbopentoxy, carbohexoxy; the most preferred embodiments of R and R being those wherein one of R and R is lower carbalkoxy and the other is hydrogen, and

R, is an alkyl group, e.g., an alkyl group of l to 24 carbon atoms, preferably a lower alkyl group, i.e., methyl, ethyl, propyl, butyl, pentyl, hexyl.

The following examples illustrate the invention but are not meant to limit the same thereto; in said examples, unless otherwise indicated, parts are by weight and the relationship between parts by weight and parts by volume is as that of. grams to cubic centimeteres; temperatures are in degrees Centigrade.

Example I.-Preparation of methyl fl (3,5-di-tertiary buty1-4-hydroxyphenyl)propionate via potassium metal To 500 parts by volume of dry tertiary butyl alcohol contained in a suitable flask (fitted with mechanical stirrer, inert gas inlet, thermometer, condenser and dropping funnel) is added 2.1 parts of potassium metal. After the ensuing reaction is complete there is added 37.3 parts of 2.6-di-tertiary butyl phenol followed by 17.7 parts of mcthylacrylate rapidly in that order. The stirred reaction mixture is heated to for 18 hours and allowed to cool. The solvent is removed under reduced pressure and the residual mass neutralized with diluted hydrochloric acid and extracted two times with 200 parts by volume portions of ethyl ether. The combined ethereal extracts are washed two times with part by volume portions of water and dried over anhydrous sodium sulfate. 'l he ether layer is then removed via filtration and concentrated on the steam bath. The residual oily mass Saponification H equivalent;

(,alculated for ClQHggOg 73. 03 ll. 65 202. 4 Found 74. 27 9. 90 2923110 In a similar way, the corresponding alkyl esters are obtained from the respective alkyl acrylates: ethyl, propyl, butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl, tricosyl, tetracosyl, etc.

If in Example I there is substituted for potassium tertiary butoxide catalyst either benzyltrimethylammonium methoxide or sodamide, then the desired product is obtained.

Example II.Preparation of methyl B-(3,5-di-tertiary butyl-4-hydroxyphenyl)propionate via potassium hydroxide The reaction conditions are the same as those employed in Example I with the exception that a slurry of 3.5 parts of potassium hydroxide in 500 parts by volume of tertiary butyl alcohol is used in the place of potassium (as the alcoholate) as the base catalyst. A somewhat lower yield of the product ester is realized by this method.

Example III.-Preparation of dodecyl fl-(3,5-di-tertiarybutyl-4-hydroxyphenyl propionate To 500 parts by volume of dry tertiary butyl alcohol is added 2.2 parts of potassium metal. Upon completion of the ensuing reaction there is added 44.6 parts of 2,6- ditertiary butyl phenol and 57.9 parts of lauryl acrylate in rapid succession. The resulting system is heated to reflux for six hours and then allowed to cool. The solvent is then removed under reduced pressure and the residual mass neutralized with very dilute hydrochloric acid. The reaction mixture is extracted two times with 300 parts by volume portions of 1:1 ethyl ether: petroleum ether and the combined extracts with two 100 parts by volume portions of water. The extract is then dried over anhydrous sodium sulfate, the drying agent filtered off, and the ethereal solution concentrated to a final temperature of 200 at a pressure of 0.1 mm. Hg. The product, dodecy] fi-(3,5-di-tertiary butyl-4-hydroxyphenyl) propionate, a viscous residue is analyzed.

Analysis:

Calculated for Cz H o 78. 1 l1. 3 Found 77.90 11. 48

Example IV.Preparation of diethyl a-(3,5-di-tertiary butyl-4-h ydroxyphenyl) succinate To 500 parts by volume of dry tertiary butyl alcohol is added 2.1 parts of potassium metal. Upon completion of the reaction 45.9 parts of 2,6-di-tertiary butyl phenol followed by 41.7 parts of diethyl maleate are rapidly added. The resulting system is refluxed for 20 hours and then allowed to cool. The reaction mixture is concentrated under reduced pressure to remove most of the solvent and then neutralized with diluted hydrochloric acid. The resulting mass is then extracted with two times 200 parts by volume portions of ether and the combined ethereal solutions with two times 100 parts by volume portions of water. The ethereal solution is then dried over anhydrous sodium sulfate and then concentrated on the steam bath. The residual oil is distilled collecting the 6 fraction boiling from 164-174 under 0.1 mm. Hg pressure. The product, diethyl a-(3,5-di-tertiary butyl-4-hydroxyphenyl)succinate, crystallizes on standing to a low melting solid.

Analysis C II Calculated for C 2 H3405 60. 81 9. 05 Found 69. 7B 0. .26

If in Example IV other dialkyl maleate esters are employed, then the respective dialkyl succinate derivatives are obtained: methyl, propyl, butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, dOcosyl, tricosyl, tetracosyl, etc.

Example V.-Preparation of fi-(3.5-di-tertiary butyl4- hydroxyphenyl)propionamide To a solution prepared by reaction 2.0 parts of potassium metal with 500 parts by volume of dry tertiary butanol is added 21 parts of acrylamide followed by 38.2 parts of 2,6-di-tertiary butyl phenol. The resulting system is refluxed for 24 hours and allowed to cool. The excess solvent is removed under reduced pressure and the residue neutralized with diluted hydrochloric acid. The mass is then extracted with two times 200 parts by volume of ether and the C mbined ethereal extracts with copious amounts of water. The ethereal layer is then dried over anhydrous sodium sulfate and concentrated on the steam bath. To the viscous residue is added parts by volume of petroleum ether and the precipitated crude product is filtered ofl. After several recrystallizations the product, fi-(3,5cli-tertiary butyl-4-hydroxyphenyl) propionamide, melts at l52.5153.5.

If in the preceding Example V. 29.3 parts of N,N-dimethylacrylamide is substituted for 21 parts of acrylanlide, then there is obtained N.N-dimethyl-fl-(3,5-ditertiary butyl-4hydroxyphenyl )propionamide.

Likewise, other N,N-dialkylacrylamides are employed to yield the corresponding N,N-dialkyl propionamide derivatives: ethyl, propyl, butyl, amyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonodecyl, eicosyl, heneicosyl, docosyl, tricosy], tetracosyl, etc. In similar fashion, also, the N-nonoalkyl amides of 1 to 24 carbon atoms in the alkyl group are prepared from the corresponding N-alkylacrylamide. Examples of such alkyl groups are the same as for the N,N-dialkylacrylamides above. See, for example, Example VIII.

Example VI.Preparation of n-octadecyl B-(3,5-ditertiary butyl-4-hydroxyphenyl )propionate To a solution prepared by adding 2.0 parts of potassium metal to 500 parts by volume of dry tertiary butyl alcohol and allowing the reaction to go to completion is added 365 parts of 2,6-di-tertiary butyl phenol followed by a slurry of 58.4 parts of octadecyl acrylate in 350 parts by volume of tertiary butyl alcohol. The resulting system, which becomes homogeneous on heating is maintained at reflux for 48 hours. The solvent is removed under reduced pressure and the residual mass is neutralized with very dilute hydrochloric acid. The mass is then extracted several times with 200 parts by volume portions of ether and the combined ethereal extracts with several 50 parts by volume portions of water. The ethereal solution is dried over anhydrous sodium sulfate and concentrated on the steam bath. The crude product is recrystallized from methanol: ethyl acetate several times to yield a white crystalline product n-octadecyl ,li-

(3.5-di-tertiary hutyl l-hydroxyphenyl)propionate, whose melting point is 4950 (uncorrected).

Example VlI.-Preparation of 4-(3'5di-tertiary butyl-4'-hydroxyphenyl)butan-lone To a solution prepared by reacting 1.2 parts of potassium metal with 250 parts by volume of tertiary butyl alcohol is added 46.6 parts of 2,6 di tertiary butyl phenol. To this stirred solution is added dropwise 26.8 parts of methyl vinyl ketone at such a rate as to keep the temperature below 65. After addition is complete the reaction mass is heated at 50 for 16 hours and then allowed to cool to room temperature. The excess methyl vinyl ketone and solvent are distilled off under reduced pressure. The residue is neutralized with very dilute hydrochloric acid and extracted with two times 200 parts by volume portions of ether. The combined ethereal layers are washed with 2 times 100 parts by volume poranhydrous sodium sulfate and then concentrated on the steam bath. The residual mass is then vacuum distilled collecting the fraction boiling from l37-l39/0.05 mm. Hg pressure. On prolonged standing the product 4-(3,5'- di-tertiary butyl 4'-hydroxyphenyl)butaneQ-one crystallizes.

If in the preceding Example VII. 109 parts of octadecyl vinyl ketone are substituted for 268 parts of methyl vinyl ketone, then there is obtained 5-(3,5-di-tertiary butyl4-hydroxyphenyll-ethyl octadecyl ketone. Other i substituted ethyl alkyl ketones are prepared in a similar way when the respective alkyl vinyl ketone is employed: ethyl, propyl, butyl. amyl. hexyl, heptyl, octyl, nonyl, decyl. undecyl, dodecyl. tridecyl. tetradecyl, pentadecyl, hexadecyl, heptadecyl, nonadecyl, eicosyl, docosyl, tricosyl, tetracosyl, etc.

Example Vlll.-Preparation of N-(n-octadecyl)-t3-(3,5- di-tertiary butyl-4-hydroxyphenyl)propionamide tions of water. The ethereal layer is then dried over To a solution prepared by reacting 2 parts of potassium metal with 500 parts by volume of dry tertiary butyl alcohol is added 41.2 parts of 2,6-di-tertiary butyl phenol and 64.7 parts of N-octadecylacrylamide rapidly in that order. The resulting system is refluxed for 72 hours and then allowed to cool. The excess solvent is removed II N Calculated for G@lI ;t ):N 7: 33 11.08 2. 64 Found T 04 11.73 2. U0

Eaxmple lX.Preparation of ethylene bis-[3,5-ditertiary butyl-4-hydroxyphenyl)propionate] To a solution prepared by reacting 2 parts of potassium metal with 500 parts by volume of tertiary butyl alcohol is added 49 parts of 2 6-ditertary butyl phenol followed by 16.8 parts of ethylene bis acrylalc rapidly in that order. The resulting system is heated to rcllux for 8 hours and cooled and the excess solvent removed under reduced pressure. The residual mass is neutralized with dilute hydrochloric acid and extracted with two 200 parts by volume portions of ether. The ethereal solution is washed with water and then dried over anhydrous sodium sulfate. The drying agent is removed via filtration and the ethereal solution evaporated to dryness on the steam bath. The resultant solid mass is recrystallized from ethanol-water mixtures to yield the desired compound, ethylene bis-I'B-(B'j-di-tertiary butyl 4 hydroxy phenyl)pr0pionate], M.P. l45.5-147 (uncorrected).

Example X.Preparation of methyl 5-(3,5-di-tertiary butyl 4 hydroxypheny])propionate without auxillary solvent To 169.5 parts of molten 2,6-di-tertiary butyl phenol under nitrogen in a similar apparatus as described in Example l is rapidly added 4.9 parts of sodium methylate. To the stirred system is added dropwise 78.8 parts of methyl acrylate over a 20 minute period. After the exothermic reaction subsides the reaction mixture is heated for an additional 3 hours at The product, methyl ,3 (3,5 di tertiary butyl-4-hydroxypheny])propionate, is isolated and purified in the fashion described in Example I, said product after crystallization, melting at 6364.5.

What is claimed is:

1. The process for the preparation of compounds of the formula:

wherein R is a member selected from the group consisting of secondary alkyl and tertiary alkyl R is alkyl each of R and R is a member selected from the group consisting of hydrogen, alkyl, aryl, alkaryl, aralkyl and carbalkoxy, and

R is a member selected from the group consisting of alkoxy, amino, alkylamino, dialkylamino, alkyl, hydrogen and the group R l l in which Z is alkylene and R R R and R are as above defined, which comprises treating a compound of the formula:

urns; amnion-icon alkyl l can tr:

1ro-- crncinooo alky] the steps which comprise treating 2,6-di-t-butylphenol with about an equivalent amount of an alkyl acrylate in the presence of from about .05 to about .25 molar equivalent of an alkali metal base or a quaternary ammonium lmsc and at a temperature of from about 40 C. to about 4. The process according to claim 3 wherein the alkali A metal base is an alkali metal hydroxide.

5. The process according to claim 3 wherein the alkali metal base is an alkali metal alkoxide.

6. The process according to claim 4 wherein the process is executed in the presence of t-butanol as a solvent.

7. The process according to claim 5 wherein the process is executed in the presence of t-butanol as a solvent.

8. The process according to claim 4 wherein the alkali metal hydroxide is sodium hydroxide.

9. The process according to claim 4 wherein the alkali metal hydroxide is potassium hydroxide.

10. The process according to claim 5 wherein the alkali metal alkoxide is potassium t-butoxide.

11. The process according to claim 5 wherein the alkali metal alkoxide is sodium methoxide.

12. The process for the preparation of methyl 3-(3,5- di-t-butyl-4-hydroxyphenyl)propionate which comprises treating 2,6-di-t-butylphenol with a substantially equimolar amount of methyl acrylate in the presence of from about .05 to about .25 molar equivalents of an alkali metal alkoxide at a temperature from about 40 C. to about 110 C.

13. The process according to claim 12 wherein the alkali metal alkoxide is potassium t-butoxide.

14. The process according to claim 12 wherein the alkali metal alkoxide is sodium methoxide.

References Cited The following references, cited by the Examiner, are of record in the patented file of this patent or the original patent.

UNITED STATES PATENTS 2,202,877 6/1940 Stevens et al 260-624 2,208,585 7/1940 Karrer 260-624 2,551,926 5/1951 Carney 260-473 2,603,662 7/1952 Stevens et a1 260-624 2,624,732 1/1953 Hitchings et al. 260-473 2,643,268 6/1953 Heinzelmann 260-590 2,681,371 6/1954 Gaydasch et al. 260-624 2,789,995 4/1957 Johnston 260-473 2,831,898 4/1958 Ecke et al. 260-473 2,881,219 4/1959 Thompson 260-624 2,969,397 1/1961 Guex 260-590 3,012,063 12/1961 Roller 260-473 3,013,062 12/1961 Richter 260-473 OTHER REFERENCES Stillson et al., J. Am. Chem. Soc., 67, pp. 303-307 (1945).

LORRAINE A. WEINBERGER, Primary Examiner D. E. STENZEL, Assistant Examiner US. Cl. X.R.

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Cited By (7)

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US4075161A (en)	1973-09-25	1978-02-21	Ciba-Geigy Corporation	Esters and amides of 2,4,6-trialkyl-3-hydroxy-phenylalkanoic acids
US4081475A (en)	1974-12-10	1978-03-28	Ciba-Geigy Corporation	Trialkylsubstituted hydroxybenzyl malonates and stabilized compositions
US4085132A (en)	1975-06-24	1978-04-18	Ciba-Geigy Corporation	Process for the production of hydroxyalkylphenyl derivatives
US4093587A (en)	1974-07-23	1978-06-06	Ciba-Geigy Corporation	Trisubstituted hydroxyphenylalkanoic acid ester and amide stabilized compositions
US4529809A (en)	1983-08-29	1985-07-16	General Electric Company	Method for production of aryl substituted esters
US4708966A (en) *	1986-06-27	1987-11-24	The Procter & Gamble Company	Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
US5354486A (en) *	1988-10-25	1994-10-11	Ciba-Geigy Corporation	Phenol group-containing compounds as anti-oxidants in organic materials

1966
- 1966-08-17 US US27004D patent/USRE27004E/en not_active Expired

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4075161A (en)	1973-09-25	1978-02-21	Ciba-Geigy Corporation	Esters and amides of 2,4,6-trialkyl-3-hydroxy-phenylalkanoic acids
US4093587A (en)	1974-07-23	1978-06-06	Ciba-Geigy Corporation	Trisubstituted hydroxyphenylalkanoic acid ester and amide stabilized compositions
US4081475A (en)	1974-12-10	1978-03-28	Ciba-Geigy Corporation	Trialkylsubstituted hydroxybenzyl malonates and stabilized compositions
US4085132A (en)	1975-06-24	1978-04-18	Ciba-Geigy Corporation	Process for the production of hydroxyalkylphenyl derivatives
US4529809A (en)	1983-08-29	1985-07-16	General Electric Company	Method for production of aryl substituted esters
US4708966A (en) *	1986-06-27	1987-11-24	The Procter & Gamble Company	Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
US5354486A (en) *	1988-10-25	1994-10-11	Ciba-Geigy Corporation	Phenol group-containing compounds as anti-oxidants in organic materials

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US3247240A (en)	1966-04-19	Process for the preparation of carbonyl compounds containing a hindered phenol group
US3330859A (en)	1967-07-11	Alkyl esters of carboxylic acids containing an alkylhydroxyphenyl group
US3644482A (en)	1972-02-22	(4-hydroxy-5-alkylphenyl) alkanoic acid esters of polyols
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US4772741A (en)	1988-09-20	Pentaerythritol co-esters containing sulfur in at least one of the acid residues
USRE27004E (en)	1970-12-15	Process for the preparation of carbonyl compounds containing a hindered phenol group
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US3681431A (en)	1972-08-01	N-OCTADECYL 3,5-DI-t-BUTYL-4-HYDROXYBENZOATE
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US3455994A (en)	1969-07-15	Process for the preparation of carbonyl compounds containing a hindered phenol group
US3281455A (en)	1966-10-25	Process for the preparation of carbonyl compounds containing a hindered phenol group
US2973380A (en)	1961-02-28	Phosphonates
US2871262A (en)	1959-01-27	Synthesis of alpha-methylene carboxylic acid esters from allene, carbon monoxide, and an alcohol with iron or ruthenium carbonyl catalysts
US3631185A (en)	1971-12-28	Synthesis of 2 4 6-tri-t-butyl-4-methoxycyclohexa-2 5-dien-1-one
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USRE27004E - Process for the preparation of carbonyl compounds containing a hindered phenol group - Google Patents

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