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KR910016330A - 엘라스타제 억제제로서 벤즈이소티아졸리논-1-디옥사이드 유도체 및 그 조성물과 용도 - Google Patents

엘라스타제 억제제로서 벤즈이소티아졸리논-1-디옥사이드 유도체 및 그 조성물과 용도 Download PDF

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KR910016330A
KR910016330A KR1019910003708A KR910003708A KR910016330A KR 910016330 A KR910016330 A KR 910016330A KR 1019910003708 A KR1019910003708 A KR 1019910003708A KR 910003708 A KR910003708 A KR 910003708A KR 910016330 A KR910016330 A KR 910016330A
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hydrogen atom
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KR1019910003708A
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KR960014782B1 (en
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로버트 래디스래스
모크자 에레머
조지 호르네벡 윌리암
마리-피엘 커네우르 크리스티앙
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원본미기재
유니레버 엔브이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

내용 없음

Description

엘라스타제 억제제로서 벤즈이소티아졸리논-1-디옥사이드 유도체 및 그 조성물과 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (36)

  1. (i) 다음 일반식(Ⅰ)을 갖는 1종 이상의 벤즈이소티아졸리논-1-디옥사이드 유도체인 엘라스타제(elastase)억제제 및 (ii)제약학적 또는 향장학적으로 허용가능한 캐리어 또는 매개물을 함유하는 조성물.
  3. 〔위식에서, R1은 수소원자 또는 C1-C5알킬이나 알콕시기이며, R2는 임의선택적으로 OH또는 COOH기로 치환된 1가의 C8-C20알킬 또는 C9-C20알케닐기이며, 또는 R2는 다음 일반식(Ⅱ)를 갖는기이며,
  5. (여기서, R3는 2가의 선형이나 가지형 C2-C6포화 또는 에틸렌 결합적 불포화 지방족기,는 방향족 핵, R4는 OH, C1-C4알킬 또는 C1-C4알콕시기, 및 n은 제로 또는 1-5범위의 정수이며, n〉1인 경우, R4기는 다를수있음) 또는, R2는 다음 일반식(Ⅲ);
  7. (여기서,R1은 상기와 동일하며, R2는 2가의 선형이나 가지형 C8-C20포화 또는 에틸렌결합적 불포화 지방족기이다)을 갖는 기이다〕
  8. 제1항에 있어서, R2는 C11-C20알킬기인 조성물.
  9. 제1항 내지 2항에 있어서, R1이 수소원자이고 R2는 COOH로 치환된 알킬기인 조성물.
  10. 제3항에 있어서, R1이 수소원자이고, R2는 노닐(nony1), 운데실, 트리데실, 펜타데실, 헵타데실 및 카복시옥틸기인 조성물.
  11. 제1항 내지 2항에 있어서, R1은 수소원자이고, R2가 알케닐기인 조성물.
  12. 제5항에 있어서, R2는 데크-9-에닐(dec-9-eny)기 인 조성물.
  13. 제1항 내지 2항에 있어서, R1이 수소원자이고 R2는 다음 일반식(Ⅱa)을 갖는 기인 조성물.
  15. (위식에서, R3는 포화 또는 올레핀결합적 불포화 2가 C2-C6지방기이며, R4는 히드록실기 또는 C1-C4알콕시기이며, n은 1이거나 2이다.)
  16. 제7항에 있어서, R2가 3.4-디메톡시신나모일, 신나모일, 디히드로신나모일 또는 P-메톡시페닐부티릴기인 조성물.
  17. 제1항 내지 2항에 있어서, R1이 수소원자이고, R2는 다음 일반식(Ⅲ)을 갖는 기인 조성물.
  19. (여기서, R1은 수소원자이고, R5는 2가의 포화지방족기이다)
  20. 제9항에 있어서, R5는-(CH2)8-기인 조성물.
  21. 상기의 항중 어느한 항에 있어서, 일반식(Ⅰ)화합물을 0.1-5중량%함유하는 조성물.
  22. 다음 일반식(Ⅰ)로 표현되는 벤즈이소티아졸리논-1-디옥사이드 유도체.
  24. 〔위식에서, R1은 수소원자 또는 C1-C5알킬이나 알콕시기이며, R2는 비치환된 알킬인 경우에는 C11-C20알킬이라는 전제하에 임의 선택적으로 한개이상의 OH 또는 COOH기로 치환된 1가의 C8-C20알킬 또는 C9-C20알케닐기이며, 또는 R2는 다음 일반식(Ⅱ)를 갖는기이며,
  26. (여기서, R3는 2가의 선형 또는 가지형 C2-C6지방족기,는 방향족 핵, R4는 제로 또는 1-5범위의 정수이며 n 1인 경우 R4는 다를 수 있다) 또는 R2는 다음 일반식(Ⅲ);
  28. (여기서, R1은 상기와 동일하고 R5는 2가의 선형 또는 가지형 C8-C20지방족기이다)을 갖는 기이다〕
  29. 제12항에 있어서, R2는 3,4-디메톡시신나모일, 신나모일, 디히드로신나모일 또는 P-메톡시페닐부티릴기인 벤즈이소티아졸리논-1-디옥사이드 유도체.
  30. 제12항에 있어서, R2가 다음 일반식(Ⅲ)을 갖는 기인 벤즈이소티아졸리논-1-디옥사이드 유도체.
  32. (위식에서, R1은 수소원자이고, R5는 -(CH2)8-기이다)
  33. 제12항에 있어서, R2는 -(CH2)5-COOH기인 벤즈이소티아졸리논-1-디옥사이드 유도체.
  34. 제12-15항중 어느한 항에 있어서, R1은 수소원자인 벤즈이소티아졸리논-1-디옥사이드 유도체.
  35. 제1-11항중 어느한 항에 따르는 조성물을 국부 부위에 적용하는 것을 포함하는 사람피부의 화장용 치료방법.
  36. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR91003708A 1990-03-08 1991-03-08 Benzisothiazolinone 1-dioxide derivatives and elastase inhibitors composition comprising them KR960014782B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9002951A FR2659327A1 (fr) 1990-03-08 1990-03-08 Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.
FR9002951 1990-03-08

Publications (2)

Publication Number Publication Date
KR910016330A true KR910016330A (ko) 1991-11-05
KR960014782B1 KR960014782B1 (en) 1996-10-19

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US (2) US5338747A (ko)
EP (1) EP0446047B1 (ko)
JP (1) JPH04234863A (ko)
KR (1) KR960014782B1 (ko)
AT (1) ATE154347T1 (ko)
AU (1) AU636013B2 (ko)
BR (1) BR9100938A (ko)
CA (1) CA2037665A1 (ko)
DE (1) DE69126460T2 (ko)
ES (1) ES2102994T3 (ko)
FR (1) FR2659327A1 (ko)
ID (1) ID820B (ko)
IN (1) IN172035B (ko)
MY (1) MY106067A (ko)
TW (1) TW200472B (ko)
ZA (1) ZA911728B (ko)

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US5512589A (en) * 1990-11-01 1996-04-30 Sterling Winthrop Inc. 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
TW226016B (ko) * 1991-12-30 1994-07-01 Sterling Winthrop Inc
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US7544754B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US8034448B2 (en) * 2008-08-19 2011-10-11 Los Alamos National Security, Llc Fibrous composites comprising carbon nanotubes and silica
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JPH04234863A (ja) 1992-08-24
ATE154347T1 (de) 1997-06-15
KR960014782B1 (en) 1996-10-19
TW200472B (ko) 1993-02-21
MY106067A (en) 1995-03-31
EP0446047A1 (en) 1991-09-11
AU636013B2 (en) 1993-04-08
AU7263591A (en) 1991-09-12
US5338747A (en) 1994-08-16
DE69126460D1 (de) 1997-07-17
ES2102994T3 (es) 1997-08-16
CA2037665A1 (en) 1991-09-09
IN172035B (ko) 1993-03-20
BR9100938A (pt) 1991-11-05
FR2659327A1 (fr) 1991-09-13
DE69126460T2 (de) 1997-12-04
ID820B (id) 1996-07-22
EP0446047B1 (en) 1997-06-11
ZA911728B (en) 1992-11-25
US5411978A (en) 1995-05-02

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