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KR870009715A - 고체 제약 형태의 제조방법 - Google Patents

고체 제약 형태의 제조방법 Download PDF

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Publication number
KR870009715A
KR870009715A KR870003527A KR870003527A KR870009715A KR 870009715 A KR870009715 A KR 870009715A KR 870003527 A KR870003527 A KR 870003527A KR 870003527 A KR870003527 A KR 870003527A KR 870009715 A KR870009715 A KR 870009715A
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South Korea
Prior art keywords
polymer
acid
nvp
process according
mixture
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KR870003527A
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KR920003575B1 (ko
Inventor
괴르츠 한스-헬무트
귄터 크리메쉬 로거
레메르히르트 클라우스
랑 지이그프리이트
잔너 악셀
쉬펭러 라인하르트
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비텐베르크, 마티아스
바스프 악티엔게젤샤프트
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Publication of KR870009715A publication Critical patent/KR870009715A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
  • Surgical Instruments (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

내용 없음

Description

고체 제약 형태의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하나 또는 그 이상의 제약활성화합물과 하나 또는 그 이상의 용해되고 제약에 허용되는 결합체 및 필요하다면 다른 통상적인 제약보조제를 혼합하고, 이 혼합물을 주입모울딩 또는 사출시키고, 50내지 180℃에서 성형시키는 고체 제약형태의 제조 방법에 있어서, 사용된 용해되는 결합제가 3.5%이하의 수분함량을 갖고, 공중합된 단위로서 20중량 % 이상의 N-비닐피롤리드-2-은(NVP)을 함유하는 용매가 없는 N-비닐피롤리돈 중합체이고, 모든 공중합된 공단량체들을 질소 및/또는 산소를 함유할 수 있고, 적어도 혼합물의 유리전이온도가 120℃이상일때, 유기용매중에서 중합에의해 얻어진 NVP중합체가 사용되거나 또는 수용액중에서 개시제로서 유기과산화물을 사용하고, 혼합물을 위액에서 잘녹지않는 어떤 열가소성제품을 포함하지 않음을 특징으로 하는 것고체제약 형태의 제조방법.
  2. 제1항에 있어서, 사용된 중합결합제가 공중합된 단위로서 60중량%이상의 NVP를 함유함을 특징으로 하는 방법.
  3. 제1항에 있어서, 가소제가 중합체를 기초로하여 20중량% 이하의 양으로 사용됨을 특징으로 하는 방법.
  4. 제1또는 2항에 있어서, 사용된 중합결합제가 폴리비닐피롤리돈으로 구성되거나 또는 N-비닐피롤리돈에 부가하여 공중합된 단위로서 단지 초산비닐을 함유함을 특징으로 하는 방법.
  5. 제1또는 2항에 있어서, 공단량체가 다음 그룹으로부터 선택된 중합결합제를 사용함을 특징으로 하는방법 : 아크릴산, 메타아크릴산, 크로톤산, 말레산, 말레산무수물, 이타콘산, 이타콘산무수물 및 C1내지 C12의 알코올을 갖는 상기 산의 에스테르 또는 상기 디카르복실산의 1/2에스테르, 및 히드록시에틸 및 히드록시프로필 아크릴레이트 및 메타아크릴레이트, 아크릴아이미드, 메타이크릴아미드, N-비닐카프롤락탐 및 비닐 프로피오네이트.
  6. 제1,2또는 3항에 있어서, 사용된 활성화합물이 물에 잘녹지않고, 용매 또는 물의 부가 없이 중합체용제에 용해시켜 분자분산용액을 얻고, 응제를 고화시킨후 고체용액을 형성함을 특징으로 하는 방법.
  7. 제6항에 있어서, 다음 그룹으로부터 선택된 하나 또는 그 이상의 활성화합물들이 사용됨을 특징으로 하는 방법 : 아세토헥사미드, 아세틸디고신, 아세틸살리실산, 아크로미신, 아니파밀, 벤조카인, β-카로틴, 클로로암페니콜, 콜로로디아제폭사이드, 클로로마디는 아세테이트, 클로로티아자이드, 신나리진, 클로나제팜, 코데인, 덱사메타손, 디아제팜, 디코우마룰, 디고톡신, 디고신, 디히드로애트고다민, 드로다베린, 플루니트라제팜, 푸로세미드, 그라미시딘, 그리세오풀빈, 헥소바르비탈, 히드로클로로로타아지드, 히드로코르티손, 히드로플루오르메티아지드, 인도메타신, 케토프로펜, 로네틸, 메다제팜, 매푸루시드, 메타안드로스테롤론, 메틸프레드니솔론, 메틸술파디아진(술파페린), 날리딕산, 니페디핀, 니트라제팜, 니트로푸라토인, 니스타틴, 에스트라디올, 파라베린, 페나세틴, 페노바르비탈, 페닐부타존, 페니토인, 프레드니손, 레제르핀, 스피놀락톤, 스트렙토마이신, 숲라디미딘(술파메타진), 술파메티졸, 술파메톡사졸, 술파메톡시디아진(술파메터), 술파페린, 술파티아졸, 술피스옥사졸, 테스토스테론, 톨라자미드, 톨부타미드, 트리메토프림, 티로트리신.
  8. 제1항 또는 2항에 있어서, 피켄츠쉬어 K값 10내지 50를 갖는 NVP중합체를 사용함을 특징으로 하는 방법.
    제1항 또는 2항에 있어서, 피켄츠쉬어 K값 12내지 35를 갖는 NVP 중합체를 사용함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870003527A 1986-04-11 1987-04-11 고체 제약형태의 제조방법 Expired KR920003575B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3612212.2 1986-04-11
DE19863612212 DE3612212A1 (de) 1986-04-11 1986-04-11 Verfahren zur herstellung von festen pharmazeutischen formen

Publications (2)

Publication Number Publication Date
KR870009715A true KR870009715A (ko) 1987-11-30
KR920003575B1 KR920003575B1 (ko) 1992-05-04

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ID=6298473

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Country Link
US (1) US4801460A (ko)
EP (1) EP0240904B1 (ko)
JP (1) JPH089551B2 (ko)
KR (1) KR920003575B1 (ko)
CN (1) CN1022666C (ko)
AT (1) ATE77739T1 (ko)
AU (1) AU587897B2 (ko)
CA (1) CA1308353C (ko)
CS (1) CS268177B2 (ko)
DE (2) DE3612212A1 (ko)
ES (1) ES2037020T3 (ko)
FI (1) FI87887C (ko)
GR (1) GR3005866T3 (ko)
HU (1) HU196132B (ko)
MD (1) MD374C2 (ko)
NO (1) NO170570C (ko)
PT (1) PT84661B (ko)
SU (1) SU1731037A3 (ko)
UA (1) UA13038A1 (ko)
YU (1) YU46534B (ko)

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NO170570B (no) 1992-07-27
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CA1308353C (en) 1992-10-06
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AU587897B2 (en) 1989-08-31
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DE3612212A1 (de) 1987-10-15
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US4801460A (en) 1989-01-31
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