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KR840006482A - 디히드로피라졸로 [3,4-b]피리딘 유도체의 제조방법 - Google Patents

디히드로피라졸로 [3,4-b]피리딘 유도체의 제조방법 Download PDF

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Publication number
KR840006482A
KR840006482A KR1019830004704A KR830004704A KR840006482A KR 840006482 A KR840006482 A KR 840006482A KR 1019830004704 A KR1019830004704 A KR 1019830004704A KR 830004704 A KR830004704 A KR 830004704A KR 840006482 A KR840006482 A KR 840006482A
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alkyl
hydrogen
cycloalkyl
substituted
dihydropyrazolo
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KR1019830004704A
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KR900006448B1 (ko
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이꾸오(외 3) 아다찌
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요시또시 가즈오
시오노기 세이야꾸 가부시끼가이샤
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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Abstract

내용 없음

Description

디히드로피라졸로 [3,4-b]피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(Ⅱ)이 화합물을 하기 일반식(Ⅲ)의 화합물과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 디히드로피라졸로 [3,4-b]피리딘유도체의 제조방법.
    [상기식중 X 및 X1은 각각 2,3 및/또는 6위치에 수소, 니트로 또는 할로겐이며,
    R1은 C1-C4알킬이고
    R2는 수소, C1-C4알킬, C4-C6시클로알킬 또는 페닐이며,
    R3는 수소, C1-C8직쇄 또는 측쇄알킬, C1-C3알킬에 의해 치환될 수 있는 C3-C7시클로알킬, 치환 또는 비치환된 페닐, C7-C9아르알킬, C1-C4알킬옥시카르보닐, 또는 산소 또는 질소 함유 5-또는 6-원 복소환기이다.]
  2. 하기 일반식의 디히드로피라졸로 [3,4-b]피리딘 유도체 및 그의 약학적으로 무독인 산부가염 및 약학적 담체의 군에서 선택된 하나이상을 함유하는 조성물.
    [상기식중 X 및 X1은 각각 2,3 및/또는 6위치에 위치한 수소, 니트로 또는 할로겐이며,
    R1은 C1-C4알킬이고
    R2는 수소, C1-C4알킬, C4-C6시클로알킬 또는 페닐이며,
    R3는 수소, C1-C8직쇄 또는 측쇄알킬, C1-C3알킬에 의해 치환될 수 있는 C3-C7시클로알킬, 치환 또는 비치환된 페닐, C7-C9아르알킬, C1-C4알킬옥시카르보닐, 또는 산소 또는 질소함유 5-또는 6-원 복소환기이다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830004704A 1982-10-05 1983-10-04 디히드로피라졸로[3,4-b]피리딘 유도체의 제조방법 KR900006448B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP57176763A JPS5965089A (ja) 1982-10-05 1982-10-05 ジヒドロピラゾロ〔３，４−ｂ〕ピリジン誘導体およびその製造法
JP176763 1982-10-05
JP176763/1982 1982-10-05

Publications (2)

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KR840006482A true KR840006482A (ko) 1984-11-30
KR900006448B1 KR900006448B1 (ko) 1990-08-31

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KR1019830004704A KR900006448B1 (ko) 1982-10-05 1983-10-04 디히드로피라졸로[3,4-b]피리딘 유도체의 제조방법

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EP (1) EP0107619B1 (ko)
JP (1) JPS5965089A (ko)
KR (1) KR900006448B1 (ko)
AU (1) AU568092B2 (ko)
DE (1) DE3372770D1 (ko)
DK (1) DK160278C (ko)
ES (1) ES525668A0 (ko)
GB (1) GB2128186B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60197685A (ja) * 1984-03-19 1985-10-07 Shionogi & Co Ltd ４，７―ジヒドロピラゾロ［３，４―ｂ］ピリジン誘導体とその製造法
US4873334A (en) * 1982-10-05 1989-10-10 Shionogi & Co., Ltd. 4,7-dihydropyrazolo(3,4-b) pyridine derivatives
GR79111B (ko) * 1982-12-20 1984-10-02 Lepetit Spa
JPS6056979A (ja) * 1983-09-08 1985-04-02 Shionogi & Co Ltd ４，７−ジヒドロピラゾロ〔３，４−ｂ〕ピリジン誘導体およびその製造法
JPS60246387A (ja) * 1984-05-22 1985-12-06 Yoshitomi Pharmaceut Ind Ltd ジヒドロイミダゾ〔１，２−ａ〕ピリミジン誘導体
US4918074A (en) * 1984-03-12 1990-04-17 Yoshitomi Pharmaceutical Industries, Ltd. Polyazaheterocycle compounds
JPS6210087A (ja) * 1985-07-03 1987-01-19 Shionogi & Co Ltd ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤
EP0355234A1 (en) * 1988-08-25 1990-02-28 Merrell Dow Pharmaceuticals Inc. Pyrazolopyridine derivatives as antiatherosclerotic and antihypercholesterolemic agents
AU725228B2 (en) * 1996-11-12 2000-10-12 Novartis Ag Novel herbicides
CA2437215A1 (en) * 2001-02-02 2002-08-15 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
US6977262B2 (en) 2001-02-02 2005-12-20 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
JPWO2004002531A1 (ja) 2002-06-26 2005-10-27 小野薬品工業株式会社 血管の収縮または拡張による疾患治療剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3857849A (en) * 1973-02-28 1974-12-31 Bayer Ag 2-amino-1,4-dihydropyridine derivatives
GR79111B (ko) * 1982-12-20 1984-10-02 Lepetit Spa

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DK160278B (da) 1991-02-18
ES8502993A1 (es) 1985-02-01
DK457583D0 (da) 1983-10-04
DK160278C (da) 1991-07-22
EP0107619A1 (en) 1984-05-02
EP0107619B1 (en) 1987-07-29
GB2128186B (en) 1986-04-30
AU568092B2 (en) 1987-12-17
AU1990283A (en) 1984-04-12
DE3372770D1 (en) 1987-09-03
DK457583A (da) 1984-04-06
GB2128186A (en) 1984-04-26
JPS5965089A (ja) 1984-04-13
KR900006448B1 (ko) 1990-08-31
JPH036151B2 (ko) 1991-01-29
GB8325024D0 (en) 1983-10-19
ES525668A0 (es) 1985-02-01

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