ES8502993A1 - Un procedimiento para producir derivados de dihidropirazolo (3,4-b) piridina - Google Patents
Un procedimiento para producir derivados de dihidropirazolo (3,4-b) piridinaInfo
- Publication number
- ES8502993A1 ES8502993A1 ES525668A ES525668A ES8502993A1 ES 8502993 A1 ES8502993 A1 ES 8502993A1 ES 525668 A ES525668 A ES 525668A ES 525668 A ES525668 A ES 525668A ES 8502993 A1 ES8502993 A1 ES 8502993A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- dihydropyrazolo
- cycloalkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FZNVQUPAVMZWJG-UHFFFAOYSA-N 2,3-dihydro-1h-pyrazolo[3,4-b]pyridine Chemical class C1=CC=C2CNNC2=N1 FZNVQUPAVMZWJG-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- JVVRJMXHNUAPHW-UHFFFAOYSA-N 1h-pyrazol-5-amine Chemical class NC=1C=CNN=1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-acetyl cinnamic acid derivatives Chemical class 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 238000006845 Michael addition reaction Methods 0.000 abstract 1
- 206010067482 No adverse event Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000002213 calciumantagonistic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000297 inotrophic effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA PRODUCIR DERIVADOS DE DIHIDROPIRAZOLO 3,4-B PIRIDINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA PRODUCIR DERIVADOS DE DIHIDROPIRAZOLO 3,4-B PIRIDINA DE FORMULA (I), DONDE X Y X SON H, NITRO O HIDROGENO; R ES ALQUILO C 1 A 4; R ES H, ALQUILO C 1 A 4, CICLOALQUILO C 4 A 6 O FENILO; Y R ES H, ALQUILO C 1 A 8 O CICLOALQUILO DE C 3 A 7. LA REACCION SE REALIZA EN PRESENCIA DE DISOLVENTES COMO METANOL, ETANOL, I-PROPANOL, BENCENO, TOLUENO Y OTROS, Y A UNA TEMPERATURA ENTRE 20 Y 100JC.PRESENTAN APLICACION COMO ANTAQONISTAS DEL CALCIO PARA EL TRATAMIENTO DE ENFERMEDADES COMO ANGINA DE PECHO, HIPERTENSION, ARRITMIA, ETC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57176763A JPS5965089A (ja) | 1982-10-05 | 1982-10-05 | ジヒドロピラゾロ〔３，４−ｂ〕ピリジン誘導体およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8502993A1 true ES8502993A1 (es) | 1985-02-01 |
| ES525668A0 ES525668A0 (es) | 1985-02-01 |
Family
ID=16019382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525668A Granted ES525668A0 (es) | 1982-10-05 | 1983-09-16 | Un procedimiento para producir derivados de dihidropirazolo (3,4-b) piridina |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0107619B1 (es) |
| JP (1) | JPS5965089A (es) |
| KR (1) | KR900006448B1 (es) |
| AU (1) | AU568092B2 (es) |
| DE (1) | DE3372770D1 (es) |
| DK (1) | DK160278C (es) |
| ES (1) | ES525668A0 (es) |
| GB (1) | GB2128186B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873334A (en) * | 1982-10-05 | 1989-10-10 | Shionogi & Co., Ltd. | 4,7-dihydropyrazolo(3,4-b) pyridine derivatives |
| JPS60197685A (ja) * | 1984-03-19 | 1985-10-07 | Shionogi & Co Ltd | ４，７―ジヒドロピラゾロ［３，４―ｂ］ピリジン誘導体とその製造法 |
| GR79111B (es) * | 1982-12-20 | 1984-10-02 | Lepetit Spa | |
| JPS6056979A (ja) * | 1983-09-08 | 1985-04-02 | Shionogi & Co Ltd | ４，７−ジヒドロピラゾロ〔３，４−ｂ〕ピリジン誘導体およびその製造法 |
| US4918074A (en) * | 1984-03-12 | 1990-04-17 | Yoshitomi Pharmaceutical Industries, Ltd. | Polyazaheterocycle compounds |
| JPS60246387A (ja) * | 1984-05-22 | 1985-12-06 | Yoshitomi Pharmaceut Ind Ltd | ジヒドロイミダゾ〔１，２−ａ〕ピリミジン誘導体 |
| JPS6210087A (ja) * | 1985-07-03 | 1987-01-19 | Shionogi & Co Ltd | ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤 |
| EP0355234A1 (en) * | 1988-08-25 | 1990-02-28 | Merrell Dow Pharmaceuticals Inc. | Pyrazolopyridine derivatives as antiatherosclerotic and antihypercholesterolemic agents |
| CN1237166A (zh) * | 1996-11-12 | 1999-12-01 | 诺瓦提斯公司 | 可用作除草剂的吡唑衍生物 |
| US6977262B2 (en) | 2001-02-02 | 2005-12-20 | Mitsubishi Pharma Corporation | Dihydropyrazolopyridine compounds and pharmaceutical use thereof |
| WO2002062795A2 (en) * | 2001-02-02 | 2002-08-15 | Mitsubishi Pharma Corporation | Dihydropyrazolopyridine compounds and pharmaceutical use thereof |
| DK1522314T3 (da) | 2002-06-26 | 2014-05-26 | Ono Pharmaceutical Co | Midler for sygdomme forårsaget af vaskulær sammentrækning eller udvidelse |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3857849A (en) * | 1973-02-28 | 1974-12-31 | Bayer Ag | 2-amino-1,4-dihydropyridine derivatives |
| GR79111B (es) * | 1982-12-20 | 1984-10-02 | Lepetit Spa |
-
1982
- 1982-10-05 JP JP57176763A patent/JPS5965089A/ja active Granted
-
1983
- 1983-09-16 ES ES525668A patent/ES525668A0/es active Granted
- 1983-09-19 GB GB08325024A patent/GB2128186B/en not_active Expired
- 1983-10-03 EP EP83810442A patent/EP0107619B1/en not_active Expired
- 1983-10-03 DE DE8383810442T patent/DE3372770D1/de not_active Expired
- 1983-10-04 DK DK457583A patent/DK160278C/da active
- 1983-10-04 KR KR1019830004704A patent/KR900006448B1/ko not_active Expired
- 1983-10-05 AU AU19902/83A patent/AU568092B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK160278B (da) | 1991-02-18 |
| ES525668A0 (es) | 1985-02-01 |
| KR900006448B1 (ko) | 1990-08-31 |
| JPH036151B2 (es) | 1991-01-29 |
| GB8325024D0 (en) | 1983-10-19 |
| KR840006482A (ko) | 1984-11-30 |
| DK457583A (da) | 1984-04-06 |
| EP0107619A1 (en) | 1984-05-02 |
| EP0107619B1 (en) | 1987-07-29 |
| DK160278C (da) | 1991-07-22 |
| JPS5965089A (ja) | 1984-04-13 |
| AU1990283A (en) | 1984-04-12 |
| GB2128186B (en) | 1986-04-30 |
| GB2128186A (en) | 1984-04-26 |
| AU568092B2 (en) | 1987-12-17 |
| DE3372770D1 (en) | 1987-09-03 |
| DK457583D0 (da) | 1983-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970612 |