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KR830005251A - 인슈린 전구체의 제조방법 - Google Patents

인슈린 전구체의 제조방법 Download PDF

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Publication number
KR830005251A
KR830005251A KR1019810000989A KR810000989A KR830005251A KR 830005251 A KR830005251 A KR 830005251A KR 1019810000989 A KR1019810000989 A KR 1019810000989A KR 810000989 A KR810000989 A KR 810000989A KR 830005251 A KR830005251 A KR 830005251A
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KR
South Korea
Prior art keywords
chain
insulin
amino group
insulin precursor
chemical
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KR1019810000989A
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English (en)
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KR840000946B1 (ko
Inventor
힐 프랭크 브루스
Original Assignee
아더 알 웨일
일라이 릴리 앤드 캄파니
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26832281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR830005251(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 아더 알 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알 웨일
Publication of KR830005251A publication Critical patent/KR830005251A/ko
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Publication of KR840000946B1 publication Critical patent/KR840000946B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

인슈린 전구체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 일반식(Ⅱ)의 S-설포네이트를 수용성 매질 ml 당 약 10mg까지의 농도로 수용성 매질중에서 각 -SSO3-잔기당 약 1 내지 5-SH 잔기를 얻을 수 있는 량의 메르캅탄과 pH 7 내지 11.5에서 반응시킴을 특징으로 하는 상기 일반식(Ⅰ)의 인슈린 전구체의 제조방법.
    상기 일반식에서
    R은 수소, 화학적 또는 효소적으로 분해가능한 아미노산 잔기 또는 2 이상의 아미노산 잔기를 가진 화학적 또는 효소적으로 분해 가능한 펩타이드 부분이고
    Y는이고(여기에서 Z는 Ala, Thr 또는 Ser임).
    A-1 내지 A-21의 부분은 인슈린 A쇄이고
    B-1 내지 B-30의 부분은 인슈린 B쇄이고
    X는 A-1의 아미노그룹에서 인슈린 A-쇄와 B-29의 ε-아미노그룹 또는 B-30의 카복실그룹에서 인슈린 B-쇄에 결합된 부위이며 이 부위는 분열이 없이 A-쇄 및 B-쇄로 부터 효소적 또는 화학적으로 분리될 수 있다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810000989A 1980-03-27 1981-03-26 인슐린 전구체의 제조방법 Expired KR840000946B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13438980A 1980-03-27 1980-03-27
US134,389 1980-03-27
US134389 1980-03-27
US210,694 1980-11-26
US21069680A 1980-11-28 1980-11-28

Publications (2)

Publication Number Publication Date
KR830005251A true KR830005251A (ko) 1983-08-03
KR840000946B1 KR840000946B1 (ko) 1984-07-01

Family

ID=26832281

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000989A Expired KR840000946B1 (ko) 1980-03-27 1981-03-26 인슐린 전구체의 제조방법

Country Status (23)

Country Link
EP (1) EP0037255B2 (ko)
KR (1) KR840000946B1 (ko)
AR (1) AR224933A1 (ko)
AU (1) AU540644B2 (ko)
CA (1) CA1154435A (ko)
DD (1) DD157612A5 (ko)
DE (1) DE3161475D1 (ko)
DK (1) DK149863C (ko)
EG (1) EG15310A (ko)
ES (1) ES500747A0 (ko)
FI (1) FI810917A7 (ko)
GB (1) GB2073204B (ko)
GR (1) GR73517B (ko)
HU (1) HU185249B (ko)
IE (1) IE51172B1 (ko)
IL (1) IL62486A (ko)
NO (1) NO151898C (ko)
NZ (1) NZ196609A (ko)
PL (1) PL127843B1 (ko)
PT (1) PT72732B (ko)
RO (1) RO81951B (ko)
SU (1) SU1301319A3 (ko)
YU (1) YU76881A (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0090433A1 (en) * 1982-03-31 1983-10-05 Genetics Institute, Inc. Creation of DNA sequences encoding modified proinsulin precursors
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE59305396D1 (de) 1992-12-02 1997-03-20 Hoechst Ag Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten

Also Published As

Publication number Publication date
DK136481A (da) 1981-09-28
NZ196609A (en) 1984-02-03
DK149863B (da) 1986-10-13
EG15310A (en) 1985-12-31
PL230292A1 (ko) 1981-11-27
PT72732A (en) 1981-04-01
NO151898C (no) 1985-06-26
FI810917L (fi) 1981-09-28
NO151898B (no) 1985-03-18
SU1301319A3 (ru) 1987-03-30
RO81951B (ro) 1984-02-28
DD157612A5 (de) 1982-11-24
HU185249B (en) 1984-12-28
AU540644B2 (en) 1984-11-29
ES8201957A1 (es) 1982-01-16
CA1154435A (en) 1983-09-27
AR224933A1 (es) 1982-01-29
ES500747A0 (es) 1982-01-16
YU76881A (en) 1984-04-30
PL127843B1 (en) 1983-11-30
DE3161475D1 (en) 1983-12-29
GR73517B (ko) 1984-03-08
IL62486A (en) 1984-12-31
RO81951A (ro) 1984-02-21
FI810917A7 (fi) 1981-09-28
GB2073204A (en) 1981-10-14
NO811039L (no) 1981-09-28
KR840000946B1 (ko) 1984-07-01
EP0037255A1 (en) 1981-10-07
EP0037255B2 (en) 1989-04-05
IE810679L (en) 1981-09-27
GB2073204B (en) 1983-09-21
EP0037255B1 (en) 1983-11-23
DK149863C (da) 1987-06-01
PT72732B (en) 1982-03-23
IE51172B1 (en) 1986-10-29
IL62486A0 (en) 1981-05-20
AU6871981A (en) 1981-10-01

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