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KR840005114A - 아제티딘 술폰산의 제조방법 - Google Patents

아제티딘 술폰산의 제조방법 Download PDF

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Publication number
KR840005114A
KR840005114A KR1019830002746A KR830002746A KR840005114A KR 840005114 A KR840005114 A KR 840005114A KR 1019830002746 A KR1019830002746 A KR 1019830002746A KR 830002746 A KR830002746 A KR 830002746A KR 840005114 A KR840005114 A KR 840005114A
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KR
South Korea
Prior art keywords
compound
hydrogen
general formula
group
amino protecting
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KR1019830002746A
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English (en)
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KR880001048B1 (ko
Inventor
레온 모니오트(외 2) 제롬
Original Assignee
조오지 제이.코에서
이이 아아트 스퀴브 앤드 산즈 인코포레이팃드
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Application filed by 조오지 제이.코에서, 이이 아아트 스퀴브 앤드 산즈 인코포레이팃드 filed Critical 조오지 제이.코에서
Publication of KR840005114A publication Critical patent/KR840005114A/ko
Application granted granted Critical
Publication of KR880001048B1 publication Critical patent/KR880001048B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

아제티딘 술폰산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식(Ⅳ)로 표시되는 화합물을 2-아미노옥시-2-메틸-프로판산 또는 그 염과 반응시키고, 하기 일반식중 R이 아미노 보호기인 경우에는 그 화합물을 탈보호 반응시킴을 특징으로 하는 하기 일반식(Ⅴ)로 표시되는 화합물의 제조 방법.
    상기식중, R은 수소 또는 아미노 보호기이고, R1은 수소 또는 C1-C4알킬기이며, M는무기양이온 또는 치환암모늄이온이고, M1은 수소원자, 무기양이온 또는 치환암모늄 이온이다.
  2. 제1항에 있어서, 하기 일반식(I)의 화합물 또는 그 염을 하기 일반식(Ⅱ)의 화합물과 커플링시켜 하기 일반식(Ⅲ)의 화합물을 수득한 다음 이 화합물을 산화 시켜서 상기 일반식(Ⅳ)로 표시되는 반응물질으르 수득함을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서, R이 아미노 보호기인 것이 특징인 방법.
  4. 제1항 또는 제2항에 있어서, R1이 수소인 것이 특징인 방법.
  5. 제1항 또는 제2항에 있어서, R1이 α-메틸기인 것이 특징인 방법.
  6. 제1항 또는 제2항에 있어서, R이 포르밀기 또는 수소인 것이 특징인 방법.
  7. 하기 일반식으로 표시되는 화합물.
    상기 일반식에서 나타낸 기호들은 제1항에서 정의한 바와같다.
  8. 하기 일반식으로 표시되는 화합물.
    상기 일반식에서 나타낸 기호들은 제1항에 정의한 바와 같다.
  9. 제7항 또는 제8항에 있어서, R이 아미노 보호기인 것이 특징인 화합물.
  10. 제7항 또는 제8항에 있어서, R가 수소원자인 것이 특징인 화합물.
  11. 제7항 또는 제8항에 있어서, R1이 α-메탈기인 것이 특징인 화합물.
  12. 제7항 또는 제8항에 있어서, R이 포르밀기 또는 수소인 것이 특징인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002746A 1982-06-21 1983-06-20 아제티딘 술폰산의 제조방법 KR880001048B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US390,728 1982-06-21
US06/390,728 US4704457A (en) 1982-06-21 1982-06-21 Process for the preparation of (3S)-3-[[[2-(protected amino)-4-thiazolyl]-oxoacetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof

Publications (2)

Publication Number Publication Date
KR840005114A true KR840005114A (ko) 1984-11-03
KR880001048B1 KR880001048B1 (ko) 1988-06-18

Family

ID=23543684

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002746A KR880001048B1 (ko) 1982-06-21 1983-06-20 아제티딘 술폰산의 제조방법

Country Status (18)

Country Link
US (1) US4704457A (ko)
EP (1) EP0097352B1 (ko)
JP (1) JPS597190A (ko)
KR (1) KR880001048B1 (ko)
AT (1) ATE30155T1 (ko)
AU (1) AU563938B2 (ko)
CA (1) CA1205076A (ko)
DE (1) DE3374008D1 (ko)
DK (3) DK163510C (ko)
ES (2) ES8503682A1 (ko)
GR (1) GR78278B (ko)
HU (3) HU194558B (ko)
IE (1) IE55234B1 (ko)
NO (1) NO832229L (ko)
NZ (1) NZ204214A (ko)
PH (2) PH18423A (ko)
PT (1) PT76896B (ko)
ZA (1) ZA833623B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484928A (en) * 1984-04-10 1996-01-16 Biochemie Gesellschaft M.B.H. 2-(2-aminothiazol-4-yl)-2-oxoacetic acid derivatives
US4647660A (en) * 1985-05-02 1987-03-03 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US4675398A (en) * 1985-08-16 1987-06-23 E. R. Squibb & Sons, Inc. Copper-mediated oximation reaction
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575803A (en) * 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
NZ205240A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
EP0048953B1 (en) * 1980-09-29 1988-03-09 E.R. Squibb & Sons, Inc. Beta-lactam antibiotics
US4443374A (en) * 1982-02-01 1984-04-17 E. R. Squibb & Sons, Inc. Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives

Also Published As

Publication number Publication date
ATE30155T1 (de) 1987-10-15
AU563938B2 (en) 1987-07-30
DK146591D0 (da) 1991-08-14
NO832229L (no) 1983-12-22
IE55234B1 (en) 1990-07-04
EP0097352B1 (en) 1987-10-07
DK163510B (da) 1992-03-09
KR880001048B1 (ko) 1988-06-18
DK280783A (da) 1983-12-22
DK106592A (da) 1992-08-27
JPH0348910B2 (ko) 1991-07-25
HU194560B (en) 1988-02-29
GR78278B (ko) 1984-09-26
DE3374008D1 (en) 1987-11-12
DK146591A (da) 1991-08-14
DK166209B (da) 1993-03-22
PT76896B (en) 1986-01-24
ES537960A0 (es) 1985-11-01
EP0097352A2 (en) 1984-01-04
DK166209C (da) 1993-08-16
PH22121A (en) 1988-06-01
ES523420A0 (es) 1985-03-16
NZ204214A (en) 1986-01-24
DK163510C (da) 1992-07-27
ES8601984A1 (es) 1985-11-01
HU190903B (en) 1986-12-28
EP0097352A3 (en) 1984-09-12
DK106592D0 (da) 1992-08-27
JPS597190A (ja) 1984-01-14
IE831382L (en) 1983-12-21
CA1205076A (en) 1986-05-27
ZA833623B (en) 1984-02-29
DK166322B (da) 1993-04-05
PH18423A (en) 1985-06-26
ES8503682A1 (es) 1985-03-16
AU1449983A (en) 1984-01-05
PT76896A (en) 1983-07-01
DK166322C (da) 1993-08-23
US4704457A (en) 1987-11-03
HU194558B (en) 1988-02-29
DK280783D0 (da) 1983-06-17

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