JP2004224702A - External preparation for skin containing mushroom extract - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new and safe humectant, prophylactic agent for immune depression or external preparation for skin. <P>SOLUTION: The humectant and prophylactic agent for the immune depression comprise one or more kinds of extracts selected from Pleurotus cystidiosus (=Pleurotus abalonus), Coriolus versicolor (=Polyporous versicolor), Elfvinga applanata (=Fomes applantus), Fuscoporia obliqua (=Inonotus obliquus), Boletus edulis, Tricholoma matsutake (=Armillaria matsutake), Tuber indicum and Phellinus linteus (=Phellinus yucatensis). The humectant and prophylactic agent for the immune depression comprise an extract from Lyophyllum shimeji or an extract from Flammulina velutipes in combination. The external preparation for the skin comprises the extracts. The extracts can be applied as the humectant, prophylactic agent for the immune depression or external preparation for the skin and even prophylaxis/amelioration of skin roughening or dry skin or luster/firmness can be imparted to the skin. Furthermore, the extracts can be utilized even as an antioxidant for the skin. Since skin immunity can be enhanced by effects on maintenance of Langerhans' cells (LC cells) normal, effects on the humectant, prophylactic agent for the immune depression or skin cancer or pigmentation caused by the immune depression can be expected. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

【００９７】
（試験結果）
表１の通り、本発明のオオヒラタケ、カワラタケ、コフキサルノコシカケ、カバアナタケ、ヤマドリタケ、マツタケ、トリュフ、メシマコブの各種抽出物については、精製水に比べ電気伝導度が高く、優れた保湿作用を有することが確認された。
更に、シメジ、エノキタケ抽出物と上記各種抽出物を併用することにより、より優れた保湿作用が確認された。
【００９８】
（試験２）紫外線によって誘導される免疫低下予防試験
紫外線（ＵＶ−Ｂ）により皮膚の免疫機能が低下されることが、近年になって知られるようになり、これらの現象は、皮膚を構成する細胞中のランゲルハンス細胞（以下、ＬＣ細胞という）が、ＵＶ−Ｂ照射により、消失することや機能低下等が原因であると考えられている。尚、ＬＣ細胞は、抗原或いはガン細胞の情報を免疫系細胞（Ｔ細胞）に伝達する機能を有し、接触過敏反応に深く関与しているものと考えられている（上田、第９回ＳＣＣＪセミナーテキスト １０（１９９６））。本試験では皮膚の免疫低下予防効果を調べるために、紫外線によって誘導される接触過敏反応の低下に対する予防効果（堀尾ら：日皮会誌 １０５（１２），１６２１（１９９５）、内田：フレグランスジャーナル９，２９（１９９１））を接触過敏反応を指標として測定し検討した。
【００９９】
（試験方法）
ａ．試料
本発明の製造例１並びに製造例３で得られた抽出液を減圧下で溶媒を留去して濃縮後、固形分濃度に換算して５．０％になる量を含有する親水ワセリン軟膏を常法により製造、使用した。
ｂ．浮腫腫脹率の測定
即ち、３日前に電気バリカン及び電気シェーバーで除毛したマウス背部に、紫外線（ＵＶ−Ｂランプとして東芝製ＦＬ−２０Ｓ・Ｅランプ使用）を、 ５０ｍＪ／ｃｍ^２照射した。その直後、被験薬物を照射部位に塗布し、さらに翌日、翌々日同様に塗布し、計３回行った。最終塗布６時間後にマウス背部に０．２％（Ｗ／Ｗ）ＤＮＦＢ溶液（１−Ｆｌｕｏｒｏ−２，４−ｄｉｎｉｔｒｏｂｅｎｚｅｎｅ，和光純薬製を、アセトン：オリーブ油４：１にて溶解したもの）２５μＬを塗布し感作させた。若起は、感作７日後マウス片側耳介部に０．２％ＤＮＦＢを２０μＬ塗布して行った。評価方法は、若起２４時間後に左右の耳介を、パンチにて切り抜き（直径約５ｍｍ）、切り抜いた耳介の重量を測定し、その差を耳介腫張値とした。尚、紫外線照射及び被験薬物で処置しない、感作操作のみを実施した動物（未照射群）を設けて比較した。尚、１０週齢のＣ３Ｈ／ＨｅＮ雌性マウスを一群につき８匹を使用した。各試料の浮腫腫脹率を表２に示した。
【０１００】
【表２】

【０１０１】
（試験結果）
本試験法で実施したＤＮＦＢ溶液による接触過敏反応の炎症を観察した結果、紫外線を照射しなかった群（未照射）の浮腫腫脹率よりも、紫外線を照射した群（対照）の方が、浮腫腫脹率の低下傾向（皮膚の免疫反応低下）が認められた。しかしながら、紫外線を照射した後、本発明のオオヒラタケ、カワラタケ、コフキサルノコシカケ、カバアナタケ、ヤマドリタケ、マツタケ、トリュフ、メシマコブの各種抽出物を塗布した群は、何ら浮腫腫脹率の低下が抑制された。このことから、本発明のオオヒラタケ、カワラタケ、コフキサルノコシカケ、カバアナタケ、ヤマドリタケ、マツタケ、トリュフ、メシマコブの各種抽出物には、紫外線による免疫反応低下に対する予防効果があることが確認された。
更に、シメジ、エノキタケ抽出物と上記各種抽出物を併用することにより、より優れた免疫低下予防作用が確認された。
【０１０２】
又、皮膚の免疫抑制は、ＬＣ細胞の傷害が関わっており、ＬＣ細胞はＥＧＦ（表皮細胞増殖因子）、ＦＧＦ（繊維芽細胞増殖因子）を分泌し、皮膚構造の維持の上で不可欠なものであり、本発明品は、皮膚構造の維持に重要なものであることが示唆できる。また、本発明品はＬＣ細胞を正常に維持させる効果により皮膚免疫を強めるため、免疫低下が原因となる皮膚ガンや色素沈着に対する効果が期待できる。
【０１０３】
（試験３）安全性試験
（１）皮膚一次刺激性試験
製造例１〜４によって得られた本発明品を乾燥固形分濃度が約１．０Ｗ／Ｖ％となるように精製水にて調製し、背部を剪毛した日本白色家兎（雌性，１群３匹，体重２．３ｋｇ前後）の皮膚に適用した。判定は、適用後２４，４８，７２時間に一次刺激性の評点法にて紅斑及び浮腫を指標として行った。その結果は、すべての動物において、何等、紅斑及び浮腫を認めず陰性と判定された。
【０１０４】
（試験４）安全性試験
（２）皮膚累積刺激性試験
同様に製造例１〜４によって得られた本発明品を乾燥固形分濃度が約１．０Ｗ／Ｖ％となるように精製水にて調製し、側腹部を剪毛したハートレー系モルモット（雌性，１群３匹，体重３２０ｇ前後）の皮膚に１日１回、週５回，０．５ｍＬ／匹を塗布した。塗布は２週に渡って行い、剪毛は各週の最終塗布日に行った。判定は、各塗布日及び最終塗布日の翌日に一次刺激性の評点法にて紅斑及び浮腫を指標として行った。その結果は、すべての動物において、２週間に渡って何等、紅斑及び浮腫を認めず陰性と判定された。
【０１０５】
（試験５）安全性試験
（３）急性毒性試験
同様に製造例１〜４によって得られた本発明品を減圧濃縮・乾燥して得られた粉末（乾燥固形分約１．０Ｗ／Ｖ％）を試験前、４時間絶食させたｄｄｙ系マウス（雄性及び雌性，１群５匹，５週齢）に２，０００ｍｇ／ｋｇ量経口投与し、毒性症状の発現、程度等を経時的に観察した。その結果、すべてのマウスにおいて１４日間何等異状を認めず、又、解剖の結果も異状がなかった。よって、ＬＤ５０は２，０００ｍｇ／ｋｇ以上と判定された。
【０１０６】
（処方例）各種保湿剤、免疫低下予防剤、皮膚外用剤の製造
上記の評価結果に従い、以下にその処方例を示すが、処方例は各製品の製造における常法により製造したもので良く、配合量のみを示した。又、本発明はこれらに限定されるわけではない。
【０１０７】

【０１０８】

【０１０９】

【０１１０】

【０１１１】

【０１１２】

【０１１３】

【０１１４】

【０１１５】

【０１１６】

【０１１７】

【０１１８】

【０１１９】

【０１２０】

【０１２１】

【０１２２】

【０１２３】

【０１２４】

【０１２５】

【０１２６】

【０１２７】

【０１２８】

【０１２９】

【０１３０】

【０１３１】

【０１３２】

【０１３３】

【０１３４】

【０１３５】
（処方例２９）被覆保護剤
ガーゼ又はリニメント布にシメジ、エノキタケ、カワラタケ熱水抽出液及び抗生物質、抗炎症剤等、適量を混合した処方液を含浸させ、外傷部に添付する。又、これらを直接、局所に散布し、ガーゼ等で被覆しても良い。
【０１３６】
（試験６）使用効果試験
本発明の皮膚外用剤及び浴用剤を実際に使用した場合の効果について検討を行った。使用テストは皮膚のツヤ・張りがない肌で悩む３０〜６０歳の１０名をパネラーとし、毎日、朝と夜の２回、洗顔後に処方例１の乳液の適量を顔面に３ヶ月に渡って塗布することにより行った。
【０１３７】
更に、処方例２８の浴用剤についても、皮膚のツヤ・張りがない肌で悩む、３０〜６０歳の１０名を対象に、３ヶ月間、必ず１日１回適量の浴用剤を溶解させた浴湯に入浴してもらい、使用テストを実施した。対照には、乳液，浴用剤から浴用剤から本発明の植物抽出物を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表３〜４の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
【０１３８】
「皮膚感触改善効果」
有 効：皮膚のツヤ・張りが増し、肌が改善された。
やや有効：皮膚のツヤ・張りがやや増し、肌が改善された。
無 効：使用前と変化なし。
【０１３９】
【表３】

【０１４０】
【表４】

【０１４１】
（試験結果）
表３，表４より、本発明のオオヒラタケ、カワラタケ、コフキサルノコシカケ、カバアナタケ、ヤマドリタケ、マツタケ、トリュフ、メシマコブの各種抽出物は、有意に肌荒れ，乾燥肌を改善し、又、肌にツヤ・張りを与えることが確認された。
【０１４２】
【発明の効果】
本発明のオオヒラタケ、カワラタケ、コフキサルノコシカケ、カバアナタケ、ヤマドリタケ、マツタケ、トリュフ、メシマコブから選ばれる１種以上の抽出物は保湿作用、免疫低下予防作用を有する。また、シメジ、エノキタケ抽出物を併用することにより、より優れた効果を発揮し、これらはヒト又は動物に対して内用又は外用しても安全なものである。
従って、保湿剤、免疫低下予防剤又は皮膚外用剤として応用することができ、肌荒れや乾燥肌の予防・改善、又は肌にツヤ・張りも与えることもできる他、皮膚老化防止用としても利用できる。又、本発明品はＬＣ細胞を正常に維持させる効果により皮膚免疫を強めるため、免疫低下が原因となる皮膚ガンや色素沈着に対する効果が期待できる。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a novel and safe humectant, immunosuppressant, and application to a skin external preparation.
[0002]
[Prior art]
Human skin is covered by the stratum corneum, a thin biological defense membrane, and the only way to live in a dry atmosphere without losing water is the stratum corneum of the skin epidermis, which is in contact with the outside world Because. That is, the stratum corneum is kept thin and supple, and the skin is adjusted in a normal state while keeping the body from losing water. However, due to various factors (for example, temperature change, humidity change, light, contact with water, etc.), the skin undergoes some changes or injuries to the skin epidermis, resulting in a functionally incomplete stratum corneum. The resulting skin, which is the so-called skin that has reached such a state, is hard, loses elasticity, and becomes dry and moist and dry. In recent years, it has also been said that such dry skin, especially Kasatsuki, is one of the causes of atopic dermatitis.
[0003]
Therefore, various cosmetic raw materials have been conventionally applied and used to prevent and supplement these points. For example, an oil or fat such as squalane is applied on the skin to form an oil or fat film, which prevents evaporation of water in the stratum corneum, or supplements intercellular lipids and the like while retaining water between lipids. Attempts have been made to form a lipid membrane to prevent the evaporation of water. However, these conventionally used substitutes are basically used only with the idea of preventing desiccation by applying to the skin epithelium. No effect can be expected. On the other hand, if the amount is too large, oily and sticky feeling is produced, and it is hard to say that the feeling of use is good.
[0004]
Therefore, in recent years, it is ideal to apply and reproduce on the skin a substance that is substantially the same as a component on the skin surface. Are coming. It should be noted that these series of natural moisturizing factors (hereinafter referred to as NMF) are known to include stratum corneum components such as amino acids, organic acids such as lactic acid and salts thereof, pyrrolidonecarboxylic acid, urea and saccharides, and others. Have been. Since the characteristics and characteristics of NMF make the skin stratum corneum hydrophilic and take in water and have a water retention action, it plays the most important role in regulating the skin stratum corneum. However, NMF causes elution due to prolonged contact with water or the like, leading to so-called dry skin, leading to rough skin, scabble, cracks and reddish creeps, reduced elasticity of the skin, and various causes of skin troubles. It is said to be.
[0005]
Therefore, recently, a substance having high hygroscopicity, such as water-soluble, is called a humectant, and is added to an external preparation for skin. Incidentally, typical humectants currently used include, for example, glycerin, sorbitol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, maltitol, sodium pyrrolidone carboxylate, hydroxyproline, ethylene oxide, In addition to propylene oxide copolymers, chitosan, and the like (see, for example, Non-patent Document 1), natural products and extracts thereof (aloe extract, Eigetsu extract, okra extract, chamomile extract, cucumber extract, lysium extract) Liquid, chlorella extract, rice extract, collagen, soybean extract, syrup extract, chimney extract, touki extract, trehalose, Bakmondou extract, beech extract, chikarasuuri extract, silane extract, mokutsu extract Etc.) (for example, see Non-Patent Document 2).
[Non-Patent Document 1] Collection of well-known and commonly used techniques (cosmetics and similar products) (1984) 22-23
[Non-Patent Document 2] FRAGANCE JOURNAL Extra Number No. 17 (2000) p. 112-115
[0006]
On the other hand, the immune function is raised as an important role of the skin. Immune function is the ability to eliminate pathogens and cells committed by pathogens that enter the living body from the outside world by phagocytosis, neutralization, destruction, etc., and the ability to destroy tumor cells, which are foreign substances generated in the living body. Can be raised. Immune function is the ability to exist not only in the skin but also in the living body as an important factor that protects the living body from foreign substances, but as described above, the skin is in contact with the outside world, so it is attacked by pathogens and ultraviolet rays from the outside world It is in an environment that is easy to receive.
[0007]
Reduced immunity leads to reduced resistance to infection from foreign pathogens and reduced ability to eliminate tumor cells, which are foreign substances generated in vivo by ultraviolet rays. In recent years, sporadic pigmentation of the skin is also considered to be a tumor of pigment cells formed by ultraviolet rays (for example, see Non-Patent Document 3), and a decrease in immunity also causes pigmentation.
[Non-Patent Document 3] Pigment cells 254-255 Keio University Press 2001
[0008]
Therefore, recently, research and development have been carried out for the purpose of solving the above problems, and it has been disclosed that an extract such as shiitake mushroom is used as a humectant or an immunosuppressive agent (for example, see Patent Document 1).
[Patent Document 1] Japanese Patent Application Laid-Open No. 11-263732
[0009]
[Problems to be solved by the invention]
However, the above-mentioned humectant has poor stability and solubility in a formulation system, and produces an unpleasant odor and coloring due to sedimentation and decomposition, and the effect at the biological level is not sufficient. Research on the usefulness of mushrooms, such as immunosuppressants, has not yet been completed.
[0010]
Therefore, an object of the present invention is to solve such a conventional problem, and an object of the present invention is to provide a novel and safe humectant, an immunosuppressant, or a skin external preparation.
[0011]
[Means for Solving the Problems]
In view of these circumstances, the present inventors have developed various extracts useful as moisturizers as the theme of their development, and as a result, selected from Ohitake mushrooms, Kawatake mushrooms, Kofukisarunokoshake, Kabaanatake, Yamadoritake, Matsutake, Truffle, Mesimakob It was confirmed that the extract obtained from more than one species had a moisturizing effect and an immune lowering preventing effect.
[0012]
Furthermore, by using the above extract in combination with an extract obtained from shimeji mushrooms and enokitake mushrooms, it has become possible to provide better moisturizers and immunosuppressants.
[0013]
In addition, by providing an external preparation for skin containing these moisturizing agents and immunosuppressants, it is useful for prevention and treatment of dryness and roughness of the skin or scalp and prevention of immunosuppression induced by ultraviolet rays. A new skin external preparation was completed.
[0014]
BEST MODE FOR CARRYING OUT THE INVENTION
As “Ohiirake” used in the present invention, Pleurotusae (also known as abalone mushroom), Pleurotus oyster mushroom (P. cystiosus (= P. Abalonus)) and the like can be used.
[0015]
The term "Kawatake mushrooms: tile mushrooms" refers to spider mushrooms (Polyaceaceae), also known as Kurotake mushrooms, the genus Coriolus (Coriolus), and the agaric mushrooms (C. versicolor (= Polyporus versicolor) (= Trametesver, etc. that can use Polyporus versicolor)).
[0016]
"Kofukusaronokishikae" is also referred to as Kofukitake mushroom (Polyporaceae), the genus Elfvinga, and the genus Elfvinga (E. applanata (= Fomes apparantus, etc.) can be used). These fruit bodies are medicinal and are called baikisei (plum infestation).
[0017]
The term "Kanaanatake" means "Hymenochaeaceae", also referred to as "Kanaanatake", "Fuscoporia", and "Kanaanatake" (F. oblique) (= Inonotus oblique).
[0018]
The term "yamatake mushroom" refers to B. edulis (B. edulis) of the genus Boletus (Boletus), which is called Boletus mushroom, Boletus, Sepp, Steinpilz, and the like in all European countries.
[0019]
The term "Matsutake: Matsutake mushroom" includes Trichomaceae (Tricholomaceae), genus Tricholoma (Tricholoma), matsutake (T. matutake) (= Armiliaria matukake), and S. matsutake (T. caligatum).
[0020]
As the "truffle", edible fungi belonging to the family Agaricaceae and the genus Agaricus (Tuber) can be used. For example, E. ginseng (T. indicum), T. magnatum, T. melanosporum, T .; aestibum, T .; macrosporum, T .; albidum and the like.
[0021]
As the “meshimakobu”, there can be used, for example, Hymenochaeaceae, Phellinus, P. linteus (= P. Yucatensis), and the like. The whole plant is medicinal and called Sou-Oh (mulberry yellow).
[0022]
In addition, “Shimeji: occupied land” can be used for Tribolomataceae, Lymophyllum, and L. shimeji, as well as L. fumosum and L. fumesum. Descastes), L. connatum, L. conger, Hypsizigus, H. marmoreus, H. ulmarius and the like can also be used.
[0023]
As the “Enokitake mushroom: Enokitake”, Trichomoloceaceae, Flammulina enokitake (F. velutipes) and the like can be used.
[0024]
The giant oyster mushroom, Kawatake mushroom, Kofukisaronokoshikake, Kabaanatake, Yamadoritake, Matsutake, Truffle, Mesimacob, Shimeji mushroom, Enokitake mushroom used in the present invention can use various parts (umbrella or handle, fruit body, mycelium, fungal nucleus), Preferably, fruiting bodies are used. The extract can be obtained by extracting these various parts as they are or after pulverizing them with a solvent, and those extracted as they are or after pulverizing can be used.
[0025]
Examples of the extraction solvent include water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol, and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, diethyl ether, and dioxane. , Acetonitrile, ethyl acetate and other esters, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more. It can be used even if it is done.
[0026]
In addition, Ohitake mushroom, Kawaratake mushroom, Kofukisaronoshikamake, Kanaanatake mushroom, Yamadoritake mushroom, Matsutake mushroom, Truffle, and various extracts of Meshimakobu, and mixtures of these with Shimeji mushroom and Enokitake mushroom extract are applied moisturizing agents, immunosuppressive preventive agents, agents for external skin preparations. Drying, concentration, dilution, or the like may be arbitrarily performed depending on the type and form to adjust.
[0027]
In addition, the production method is not particularly limited, but it is usually sufficient if it is in the range of the boiling point of the solvent under normal pressure from normal temperature, and after extraction, filtration or use of an ion exchange resin, adsorption, decolorization, and purification are performed. It may be in the form of a solution, paste, gel, or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to an extracted substance may be arbitrarily selected.
[0028]
Ohitake mushroom, Kawaratake mushroom, Kofu sarakoshikamaki, Kabaanatake mushroom, Yamadoritake mushroom, matsutake mushroom, truffle, various extracts of Meshimakobu, and a mixture of these with Shimeji mushroom and Enokitake mushroom extract as they are, as moisturizing agents, immunosuppressants, and external preparations for skin It can be blended, and its blending amount is not particularly limited, but slightly varies depending on the type, quality, expected degree of action of the moisturizing agent, immunosuppressant, and external preparation for skin, and is usually 0.0001% by mass or more. (Hereinafter, expressed in%) Preferably, 0.01 to 50.0% is good.
[0029]
In addition, the moisturizing agent, the immunosuppressive agent, and the external preparation for skin of the present invention may be, if necessary, in addition to the above-mentioned essential components, pharmaceuticals, quasi-drugs, cosmetics, etc. within a range not to impair the effects of the present invention. It can be manufactured by arbitrarily selecting and using the components and additives used in the preparation of (1).
(1) Various fats and oils
(1) Various fats and oils
Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard , Squalene, squalane, pristane, hydrogenated products of these oils and fats (hardened oils, etc.) and the like.
[0031]
(2) waxes
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.
[0032]
(3) Mineral oil
Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.
[0033]
(4) Fatty acids
Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acids, Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid.
[0034]
(5) Alcohols
Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.
[0035]
(6) Polyhydric alcohols
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.
[0036]
(7) Esters
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.
[0037]
(8) Metal soaps
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.
[0038]
(9) Gum, sugar or water-soluble polymer compound
Gum arabic, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan, alkylene (C2-C4) oxide, such as ethylene oxide, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, potassium Boxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or a crosslinked polymer thereof, a carboxyvinyl polymer, polyethyleneimine and the like.
[0039]
(10) Surfactant
Anionic surfactants (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactants (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing nonionic surfactant), other surfactants (natural surfactant, protein) Derivatives of hydrolysates, polymeric surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0040]
(11) Various vitamins
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxerol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0041]
(12) Various amino acids
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And their amino acids such as sulfates, phosphates, nitrates, citrates, and pyrrolidone carboxylic acids.
[0042]
(13) Various additives derived from plant or animal raw materials
These are processed in a conventional manner according to the type and form of the product to be added (eg, pulverization, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization). , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., are arbitrarily selected and combined), and arbitrarily selected from various materials.
[0043]
The solvent used in the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but is usually selected from water, methanol, ethanol, propyl alcohol, isopropyl alcohol, and butanol. , One selected from lower alcohols such as isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone and ethyl acetate. Alternatively, it is desirable to use a mixture of two or more. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.
[0044]
In addition, when an additive derived from a plant or animal-based material is applied to a systemic or topical external preparation or cosmetics, the skin and hair are protected, the moisturizer is improved, the feel / feel is improved, flexibility is imparted, and stimulation is provided. Mitigation, alleviation of stress by aroma, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin and hair quality, prevention and improvement of rough skin, hair growth, hair growth, hair loss prevention, gloss imparting, cleaning effect, In addition to cosmetic effects such as alleviation of fatigue, promotion of blood flow, and warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.
[0045]
In foods and drinks, nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and other health and cosmetic effects, improvement of taste, color and aroma, gloss imparting, stabilization, thickening, It can be used for antiseptic purposes. Furthermore, in addition to the above, various cosmetic and pharmacological effects of each raw material known so far are expected, and by combining these, the intended effect can be enhanced or multifunctional. It is also possible to make a product that expects an effect.
[0046]
Specific plants (herbal medicines) as raw materials include, for example, almonds (herring peach), eyes (blue leaves), blue moss (Seifu wisteria), blue oysters (Aoki), blue oysters, or kenashiogiri (Otogi), and blue oysters (Komi) , Aotema, acacia, red ginger (red maize), red crocodile "fruit", red clover, red grape, red akaminoki (logwood), red akameshiwa (red bud), red akamane or rape or madder (akane grass root), red pheasant or pheasant (land yellow), Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Omiten palm), Akebi (Kidori), Asa (Jinji), Malva Asagao or Asagao (Toshiboshi), Hydrangea (Hydrangea), Ashitaba (morning leaves), Azuki (red azuki bean), Asunaro, Acerola, Acene Ku (Asenyaku), Achilla (Shokuyoukanna), Anise, Abiu, Abiurana, Brassica, Abemaki "fruit", Avocado, Ama, Amacha (sweet tea), Amacadul, Amadokoro (Tamatake), Amana (Kojingi), Amaranth (Amaranthus, Balsam pear, Hymenoptera, Senninkoku, Sugimorigeito, Hosoaoigato, Aogaito, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Yurizisen), Arcana (Alcanabo), Alcana , Althea, Arnica, Alpinia or Katsumadai (Sou-zuku), Aloe (lux), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azuka), Yellow sapote, Igakouzolina , Epimedium or Epimedium (Indian kaku), Igusa (Water heart grass), Itadori (Tiger root), Yew (No. 1), Strawberry, Fig (Figurine "fruit, leaf"), Ichihatsu (Primary), Ichibi (Winter Aiko) ), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo "seed, leaves"), Itohimemegi (Enshi), Carob, Inosumanus (Teilexi), Inuyuyu (Honaguinubiyu), Rice "seed, seed coat", Inondo "seed", Ibukijakosou, Nettle, ylang-ylang, iwa tobacco (Iwagashi chi), iwahiba or iwamatsu (makikashi), kidney bean, oolong tea, fennel (feng scent), wheat (chibusanoki), ukiyagara (sanraku), squid "fruit", hime uikyo, turmeric Ukukushi), duckweed (floating), usubasaishin or keirinsaishin or cattle Hyacinthus (spicy), Usbania oyster, Usbenitachiaoi, Uchouran, Utsubogusa (summer hay), Udo or Shisiudo (Qanggai, Independent, Tang Dungyo), Unyadegato (Unkaria, Cat's Claw), Uba tea, Ume (Ume (seed, flesh) )), Vladimir, Elephant's walnut (Kusakomomo), Unshurikan (Chen skin), Eunboku, Estragon, Ezocogi (Ezo Goka), Ezo lily of the valley, Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (Enotake mushroom), Ebisugusa or Mise ), Elcampre, Elderberry "fruit", Elemi, Eryngii or Pre-Lotus Erinji, Enju (Gooseblossom, Sophora blossom rice), Pea, Ohgi or Kibanaohagi (Ascot radix), Narco lily or Kagikurumabanarukoyuri (Yoshisei), Ohisasanoyuki Is Sasanoyuki, Ouren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Public engineering incense), Ootsu ヅ rafuji (self-defense), Oobako (car forehead, car front grass), Obanana thistle (Keju oakashi, baekshio), toucan (Haruko), Toucan cactus, Obanana okera or Okera (white jujube), Obanassarsbergi (Banaba), Obanayashabushi "fruit", Ochosigusa (grain sperm), Oumia catechu, O hawthorn or hawthorn (mountain sprout), Omi palm, barley ), Oka, okazeri (snake bed), okra "fruit", ogura (turnover), okururihigotai (Ushu sashimi, indigo sashimi), panax ginseng or horseshoe ginseng (carrot), hypericum or lycopodium perforatum or periwinkle Younger cut grass), dragonfly (intermittent), oh Fir (blue ears), onigorumi, onidokoro or tokoro or nagadokoro (hikai), oninoyagara (Tianma), onyuri or sasasayuri or hakatayuri (yuri), onoelan, ononis, halibut (hibayu), ominaeshi (soy sauce), oyuko , Dutch mustard (watercress), Dutch jelly, Dutch biyu, Dutch honeybee, olive "fruits, seeds, leaves", oregano, orange "fruits, pericarp", caycaio (ripe yellow), cacao "fruits, pericarp, seeds", oysters (Persimmon "leaf"), kagi kazura (chou hook), kakidooshi or kantosou (rensensou), kakiran, gaku hydrangea, cassia, casino (kozomi "fruit"), gajutsu (shadowjutsu), kashiwa (shiki, Shakuha), Kascarilla, Kascara sagrada, Gypsophila, Kaffir lily, Kanixa (Kin Sato), Kaniwa, Ka Nation, valerian root (valerian root), hippopotamus, birch or weeping birch (white birch), gerbera, squash, kapok-no-ki (seed), kahoku sansho (pepper), gama (bamboo), chamomile or roman chamomile, chamite (herb), camu cam (Duck), Karaguwa or Yamaguwa (mushroom), color, karaksakeman, crow squirrel or cinnamon cucurbite (roasted melon), crow sabisaku (midsummer), mussels, guarana "seed", karahoo (thick), karaya, galyu, karin ), Garcinia, Kawamidori, Kawara Psycho (Kelyo greens, white-leaved grass), Kawazusha, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawarangin (Blue potato), Kawamuragi (In ??) Ko), Kansui (sweet), Licorice (licorice), Kantarasa, Kandelilla, Kanto, Canna, Kanran, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Maple strawberry, European strawberry), Kiwi "Fruits, leaves", Kikarasuuri (Kuroro root), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Shima kaniku, Daffodilium), Chrysanthemum, Catalpa (Azusa), Giant stalk (Yotei root), Pheasant (Komi), Kizuta, Kidachi aloe, Kidachiha, Kinna , Linden (shincona, red linden), quinoa (quinoa), yellowfin (huangbashi), pigeon pea, gymnema sylvesta, kimmenkaku, cabbage, cabbage "immature fruit", caraway, cucumber, goryuu (Nishikawayanagi, teriyaki), kiraja Saponaria, Kiraya, Kiranso Peanut grass), kumquat "fruit", kinkiju, ginsekai, kimbusen, betel, kinmizukiki (senkaku grass), quinran, ginran, kinryohen, guapeba vermelha, guava "fruit", guayule, quelux infectria (gallicate), kukuinuts , Kugenumaran, wolfberry (Gugi, gugi, gugi leaf, ground bone bark), Sugisugi Kazura (Tenmen Fuyu), Kuzu (Kakkon), camphor tree, gooseberry "fruit", Xining ginseng (Huanghuako), cutiti river, gardenia ( Gardenia), kunugi (bokusou), kupuasu, kubeba, kumazasa, kumamatsura (horse whip grass), clara (bitter scallop), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit " Fruits and leaves ", buckthorn, black stalk (rescue required) Kameba Hikioko or Kurobana Hikioko or Hikiokoshi (extended life grass), clove (clove, clove), gumbinazuna (sekimei, sekimeishi), kaigai (infestation, infestation spike), cadmium (corolla, cockscomb), gekkavidin, bayberry (laurel tree) Sartorii rose (Tokubukuryo, mountain return), gentian, genoshoko (Oirou grass), Kemponashi (Kigushi), Koukisekikoku, Kishumican (Koji, Tachibana, Obeninican, Fucremican, Sagamikouji, Ponkan, Santara (tachibana)), Koshinbara (Tachibana) Monthly flower), Kosui mentha, Kozo "fruit", Kocha (tea), Kouhone (river bone), Kouhon (straw and kara straw), Kouriang, Kourikyo (Korajang), Cilantro "fruit", Kouren (huohren), Sorghum (Yellow Gon), Cowberry (Koshibachi), coconut "fruit", goshuyu (goshuyu), goshoichigo (covered bunko), pepper (pepper), cosmos, copaiba balsam, coffee "seed, leaf", kobushi or magnolia (spice), burdock (burdock) Burdock, burdock, sesame seeds, sesame, sesame seeds, sesame seeds, sesame seeds, gomeshi, scallop or binankazura or pine bush, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata "Seeds", Cola Vera "Seeds", Coleus Forskoli, Colony Lya, Fenugreek "Fruits", Colombo, Kondulango, Kombu, Konjac, Comfrey (finnari grass), Sisal (Sisal Asa), Saihailan, Sakanelan (Ezosakaneran), Sakisima button or sina button or sap Kura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "Leaf, flower, fruit, bark (cherry bark)"), cherry, pomegranate, sasa, sasabagi Sasanqua, Sajiomodaka (Sawahka), Sweet potato, Sugar cane, Sugar beet, Sanebu jujube (Satsumitsujin), Saffron (Safflower, West safflower), Sapodilla, Sapotea mariyo, Pomelo "Fruit", Sabonsou, Salmonberry "Fruit", Sarasin Hemp), saransitou (sand sashimi head), salvia (sage), sawagyoukyo (yamakonasai), sawagumi (yamawalnut), sankaku cactus, sangre degrad (croton), sansouyousou, sanshinjinjin (seven carrots) , Sanshi Yu (Susyuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shitake mushroom), Shion (Shion), Shikaku bean, Dikitaris, Shikunshi (Kimiko), Shiso or Aodiso or Chirimenzo or Katamenziso (Shiyo leaf, Shiso), Rosewood, Linden tree, Chinese pine, Chinese beetle (ream forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiiroshimeji, Bunashimeji, Honjimesi, Shirotamotake mushroom) , Potatoes, peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat stalks), ginkgo salmon, sycamore, sakushamitsu (sand vines, sand compaction), juzdama, palm "fruit" , Shunran, palm palm, ginger (raw) Kiang), Japanese hydrangea (Tsuneyama), Shobu (irises, iris root), Shozuku "fruit", Shirazak "seed", Silane (Byancyuu), Shirogoshi butterfly "seed", White clover (clover), White adzuki (chicken bone grass), Shirobanairisu (Small iris), Shirobanatsuta "flower", Shirobanana lupine, Shirominanten (Minami Tenmi), Cinchona sassil Silbra, Jinchouge (Mizuka, Mizuka, Shencho flower), Cinnamon, Cinnammum cassia (Citrus), Watermelon (watermelon), Honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid pattern), swim berry "fruit", star apple, stevia, strawberry "fruit", suzu psycho (successor lord), horsetail (question), suberhide (horse ken, horse teeth kenko) ), Plum “fruit”, Surugaran (Oran), Scots pine “cone”, European larch, Scots vine, Scots walnut, Scots hawthorn, Scots blossom, Scots dandelion, Scots cypress (Marronnier), Scots pear "fruit", Scots sycamore, Scots stalk (Elder), Scots squirrel (Junipa, swordfish) ), Rose, cornflower, mistletoe, mint or mint, horseradish, horseradish (stone iris), seaweed (seaweed, seaweed, seaweed, seaweed, seaweed) Noseckko (Dendrobium, Ishimasu), Cedron (Bowshukuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Senkyu ( Cucumber), sensin ren (percussion ream), sendan, sennin cactus, senna "fruit, leaf", senninsou (great tate), senburi (medicine), senboku, souka (grass), elegans, shinshinbai, buckwheat "seed" , Somenimo, Broad bean, Rhubarb (Daihuang), Radish, Soybean, Daidai (Orange, Kikomi), Takasagouri Rigogotai (Southeast indigo sashimi), Takasaburo (Dried lotus grass), Takatodai (Daigo), Takagawarabi , Dark sweet cherry "fruit", hollyhock, tachi-kosou (thyme, momoka), hachidokoro (hikari), hollywood, tamarind "seed", onion, tamashiba (spicy), taro tree "fruit, leaf, root bark", tarayou (large leaf) Winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenjikubotan), tarwi, tankiri bean, tanshiu Chihuahua, Tanjin (Dan ginseng), Dandelion (Gambakoei) or White dandelion or Moko dandelion, Dammar, Cherry "fruit", Tigaya "fruit, root, bud", Chixet ginseng (Bamboo ginseng), Chicory, Chancapiedra (Kidachiko Mikansou) , Tulip, Choconostay, Artichoke (Artichoke), Artichoke (Ohta), Artichoke (Wuyi), Artemisia (Aoba), Choreimaitake (Irei), Chorogi, Tsukimimiso, Tsukushikaneran, Tsukuritake (mushroom) , Tsuchiakebi, Camellia, Camellia, Tsumekusa (lacquer lacustrine), Tsujukusa (Duckweed grass), Tsuruazuki (red azuki bean), Tsurutsuchiakebi, Tsurudukudami (What's neck crow), Tsuruna (Kyoto), Tsurujinjin (Four leaf ginseng), Tsuruame, Tsuwabuki, Deiko, Teuchigurumi Duberry "fruit", tengusa, tencha (tencha), tendaiyaku (crowd), touga (winter gourd), toukagizura, capsicum (bancho), touki (return), tokinsenka (marigold), toukaichi, tounabena ( River cut), corn or corn hair (Nanbaru hair), horned rice mochi (female child), lindeau or Korean gentian (dragon and gall), foxtail (pirate), dokudami (ten medicines), konkon (sore root), sushi or mamedaoshi or Asparagus, Eucommia (Tochu "bark, leaves, roots"), Ash (Hata bark), tomato, tragacanth, triacanthos "seed", eustoma, tormentilla, dronoki, troroaoi, tongue bean, nigeria berry "fruit", potato or yam Yamayaku), Nagi-kida (butcher bloom), Ginata Kouju, Nazuna, Rapeseed, Rape Beans or Nail Bean (Sword Beans), Natsumikan, Jujube (Dajutsu), Naniwaibara (Kanekurako), Navena (Continuous), Nameko, Peanut (Peanut), Nanten (Nantenmi), Namban Karamushi ( Ramie), Scented violet, Nigaki (bitter tree), Artemisia (bitter tree), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabunikei (cinnamon bark) or Keishi (Keishi), Gyokubuchidori, Chive (Niriko), Elderberry (Negishi) "Fruits, flowers, stems, leaves"), garlic (garlic), nurde (fivefold), green onion, nemuki or neb or nebi or nemlinoki or digokubana (healing), nozami (daiji), noybara (business fruit), nozenkazura (ryohana) ), Scallop, yarrow, sawdust (maehu), nobara, peach, pineapple "fruit", ha Ibiscus (Bussouge, Furin-Bussouge, Roselle), Hi-Gindo, Hauchiwa, Pau Dosse, Hakamauraboshi (Bone Crusher), Hakuka Yumatou, Hakusanchidori, Hakusen (Rinosaur), Hakuruberry "Fruit", Hakomi (Horoshi), Hashibami (Haruko) ), Hasiridokoro (Roth root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland jelly), Naked mulberry, Batata, Hachik or Madake (Bamboo-boiled), Patchouli, Mint (Light-weight, Light-weight leaf), Hashi-shome, Adlay (Yokuinin), Hanasuge (Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Japonica (Rabbit malt), Pahalobobo, Hub "Whole grass, stem, leaf", Paprika, Hamakakiran, Hamago Or mitsubahamago (vine thorns), hamasuge (katsuki), ha Bishi (Situriko), Hamanas (Maikai flower), Hamabofu (Beach storm), Hamamelis, Palm, Rose (Roses), Balata, Balata rubber tree, Haratake (Haratake, White-faced Oharatake, Usukimori no Kasa), Haran, Paliurus , Harkanran, Balsamina (Tsurureishi, Nigari), Harunire (Yellow, Yuhakuh, Yuba), Barbasco, Harindou, Handaikai (Matsudaikai), Breadfruit, Hiougi (Shadow), Hikagetsurinjin (Partisan), Pecannut, Amaryllidaceae (Shirubana, Hiragana), Higuru Madaria, Higashitai, Hishi (Ryomi), Pistachio, Beet, Aedes (Ashiedashi), Aedes aegypti, Daisies (Daisy), Aesculus chinensis (Cow Knee), Hinata Bulrush, Hinoki , Hiba, Castor, Sunflower Bell pepper, Himeuzu (Tamaoi), Himegama (incense blossom), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta "Fruit", Juniper, Beakkyuu, Hiyu "Fruit", Chickpea, Flounder, Beloudooi, Hiroohinagusa , Loquat "fruit, leaf, stem", betel nut (large clothes skin, betel nut), Puer tea (pu? Tea), spruce buds (southern rattan), butterflies, butterbur poppies (winter flowers, winter leaves), fujibakama (orchid grass), wisteria beans (flat beans), fujimodoki (butterfly clover, pine flowers), grapes "fruit, peel, seeds, leaves", beech , Fuyumushinatsukutake (Cordyceps sinensis), Brazilian liquorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry, Branjen, Plum "fruit", Flucellaria, Blueberry (Prunus avium), Prune , Floral Blanca, Blond Psyllium, Bundo (Mung Bean), Hazelnut, Loofah, Hetkaran, Safflower (Safflower), Henneken, Belladonna, Berry "Fruit", Persair, Perbianberg, Pereschia Grandifolia, Benkeiiso or Ikuxa (Keiten), Boy Berry “fruit”, squirrel or mulberry or gentian or squirrel or kokia (skin), spinach, balsam (blossoms, acute offspring, osteophyte), potteria sapota, potteria lukma, spinach, spinach, squirrel (toro root) ), Bonito (Japanese magnolia, magnolia), bokeh (gourd), hosoba aburagiku (bitter gourd), hosobaoguruma, hosobananaokera (sojutsu), hosobanokirinsou (Kageten Sanshichi), hosobabarengiku, bodaiju (bodice tree), button ( Peony "flower, leaf, stem, bark"), buttonpi (peony bark), hop, jojoba, borage (ruriichisha), bordeaux, white berry "fruit", hon-onik (meat porcelain, daigei), hon-sekko (iron skin) Stone mackerel, sparrow mountain stone mascara), myzurutennanshaw (Tennan star), maitake (maitake), ephedra (maoh), maca, Cademia nuts, Margaret (Mokshungiku), Macri (Martian grass), Magwa (Mulberry white bark "bark, leaves"), Magnolia splengeri, Masalampuba, Masaranzuba do Ceara, Masaira de Boi, Mashua (Tamanowen) Haren, Kyukonkinrenka, Matatabi (Kiten Tate), Matsukasa, Pine "leaves, bark, roots", Matta Oryo, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanahakka), Malvanozadin (Together), Mulberry "Fruit", quince, malein (belowed squid), mango, mangosteen, mansagna (andesukamitsure), manshugulumi, mandarin "fruit", Mannentake (reishi), pheasant (Komimi "fruit"), Mishimasaiko (Shibako) ), Japanese plantain or Japanese morning glory ( Dragon tongue grass), mizokokushi (half-edge lotus), misohagi (senkakuna), beetle or elder willow (meditative), mitsugashiwa, honeywort, midori sapote, midorihakka, mimosa, myoga, miracle fruit "fruit", myrrh, mirobaran, mugiwaragiku , Mukuge (Mokugei), Mokumuki, Mokumoji (prolonged skin), Munya, Murasaki (purple root), Murasakisikibu or Omurasakikibu (purple bead), Murasaki maize, Murasaki natsufuji (Kunming chicken blood Fuji), Megakanza opuntica, Mehajiki ), Mebogi, Japanese primrose (Evening primrose), Melaleuca, Melissa, Meliloth, Melon "fruit", Mokogi mugi, Moso bamboo, Mok giraffe, Moje (Kouboku), Mochinoki, Mokko (mochi), Momijibadaio, Peach (peach "leaf, Seeds, flowers, berries "), sprouts Morero cherry "fruit", moroheiya (burlap), yakawamurasakiimo, yakuchi (masuchi), cornflower (cornflower), cornflower mint, yacon, yaba santa, yashabushi (arrow wheel) or himeyashabushi or himeyashabushi "fruit, peel, fruithead" ) , Dronoki), Salix spider “leaves, stems”, scabbard, squabium (purple beef), squid tobacco (crane squirrel, Tenna sei), pokeweed (land), yamanoki (yamaharu), yamamomo (yang plum skin), yamamogi, yu Li, Saxifraga (tiger ear grass), Yucca or flevifolia, Yuzu "fruit", lily, yorogusa, mugwort (Aiba), ligan (Rainaramaru), lime "fruit", rye, lacanca "fruit", raspberry "leaf, fruit" ”, Latania (Clameria), Rakkyo or Shallot (scallop), lavender, longan (longan meat), agave (Aono agave, fukurin agave), ryocha (green tea), apple“ fruit, seeds, leaves, roots ”, gentian, rubus or Suabisimus (sweeten), Ruritama thistle (Urajirohigotai, Xinjiang indigo head), litchi (Lichi, lichi nucleus), lettuce (Chisha), red currant "fruit", red pitaya, lemon "fruit", lemongrass, forsythia or Chinese Forsythia, Astragalus, Astragalus, Waimei, Uyashi, Lokon (Yoshi, Ashine), loganberry "fruit", rosemary (Rosmarinus officinalis), rose hip (Novara), wasabi, Watafujiutsugi (dense Komuhana), burnet (Chinire), and the like.
[0047]
Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usbaaonori, Sujiaonori, Hiraaonori, Bowaonori, Hosoedaaonori), Anaausa (Aosa) and seaweed [Brown algae] (Macomb, Resiliconbu, Hosomebu, Mitsuikonbu), Wakame, Hirome, Aookame, Giant Kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys Luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa, Kiribano Sea Prickly Pear, Akabumi Prickly Pear, Konau Prickly Pear, Okinawa Prickly Pear, Usuki Prickly Pear, Ecchi Prickly Pear], Seaweed [Red Algae: Hijirimen, Maxa (Tengusa), Hiracusa, Onixa, Obaku ) Kainori, Yaleus Banori, Kagius Banori, Sujius Banori, Hyus Banori, Akamomininori] and the like.
[0048]
In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Genus kuwanomimo, Volvox: Ohigemawari, Volvox, Palmera, Yotsumemo, Aomidro: Hizaori, Spirogyra, Papilio spp., Hibimidro spp .: Hibimidro spp. Echinacea spp .: Echinacea spp., Iwata spp .: Husaiwata, Sricogulata, Helaiwata, Crocita, Janemo, Mir spp .: Mill, Cromil, Sakibuchimil, Nagamil, Hira Le, Casanori: Casanoli, Jusmo: Futozuzumo, Tamazuzumo, Mizojusmo, Mikazukimo, Korekaete, Tsuzumimo, Kikkogusa: Kikkougusa, Hitoexa Genus: Hitougusa, Hirohanohitengusa, Utsutoegumo, Genus Sumiremo: Sumiremo, Hoshimidoro, Fushinashimidoro etc.).
[0049]
Blue-green algae (Genus L .: L., L., L .: Kawatake, Ishikurage, Hassai, Juremo, L. (spirulina): Spirulina, Trichodesmium (Aiakashio), etc.).
[0050]
Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami spp., Isogrape spp .: Isogrape, Isogawara spp .: Isogawara spp. , Genus Sanadagusa: Sanadagusa, Fukurinamiji, common genus: common rush, terrestrial genus: Ezoyahazu, Yahuzugusa, Uraboshiyahazu, genus Genus: jigamigususa, Umiuchiwa genus: Genus genus, genus genus, genus Genus : Nabarimo, Chasoumen: Motsucha-chasomen, Matsumo: Matsumo, Nagamatsumo: Nagamatsumo, Okinawamozuku: Okinawamozuku, fake Genus Tomozuku: Niseftomozuku, Genus Futomozuku: Genus Futomozuku, Genus Genus: Ishimozuku, Genus Cromo: Chromo, Genus Nisemozuku: Nisemozuku, Genus Mozuku: Mozuku, Genus Ishige: Ishige, Genus Genus: Ichimegasa, Callarial spp. Umibos, Urushigusa genus: Urushigusa, Keulushigusa, Tobacco moss, Kombmodoki: Kombudoki, Hambamodoki genus: Havamodoki, Habanori genus: Habanori, Hiranohabanori genus: Habanori, Commonbukuro genus: Commonbukuro, Ezobukurono, Ezobukurono, Ezobukuronozo, genus Genus genus: genus genus: genus kagomenori: genus kagomenori, muralidori: murachidori, sharksugusa genus: sharksugusa, iwahige genus: iwahige, yokojimanori genus: yokojimanori, Genus: Cyperus, Fennel: Fennel, Turmo: Turmo, Anana: Aname, Sujime: Sujime, Miss kelp: Miss kelp, Atsuba Miss kelp, kelp: Gatsugara kelp, Kakisima kelp, Oni kelp, Gohei sorghum, Gohei kelp, Gohei sorghum Genus Oleoptera, Trolocomb: Trolocomb, Antokume: Antokume, Swordfish: Swordfish, Tsurarame, Kurome, Asterina: Asterine, Nesulecomb: Nesirecomb, Kuroshiome: Kuroshiome, Nekoashikame: Acerium, Araumenu Genus: Ainu-Wakame, Chigaiso, Oniwakamezo-Ezoishige: Ezoishige, Yabanemoku: Yabanmoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jo Lomoku, Hiemoku, Hondawara: Tamanamoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametara, Tatsukuri, Yasumatamoku, Umitoranoo, Oobamoku, Hashimomoku, Haikumokugi, Hawk Mokumoku , Genus genus: genus oleum, genus bulumium: genus bulumium, genus kayamoris: kayamoris, etc.).
[0051]
Red algae (Coleoptera genus: genus oxenori, fenori no moss, Amanori genus: Asakusanori, Susabinori, Uppulinori, Oniamanori, Tasa, Filitasa, Benitasa, Rhodocorton genus: Milnoveni, Akebonomozuku, Agenidae, Genus: Sea elephant, Tsukumonori, Kamogashiranori, Benimozuku: Benimozuku, Hosobenimozuku, Kasamatsu: Casamatsu, Fusanori: Fusanori, Nisefusanori: Nisefusanori, Sodegarami: Sodegaramiragara, Gallaghera Genus: Tamaitadaki, genus genus: genus kaginori, genus chinensis, proboscis genus: scrophularus, scrophium, oobusa, nambugu , Kohira, Yohira, Kinukusa, Hibiroudo: Hibiroudo, Himehibiroudo, Isomemudoki: Isomemudoki, Michigaesou: Michigaesu, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekisuba, Nisekareqaba, Nisekarekubasa Genus Naminohana: Hosobanaminohana, Naminohana, Coralthrum Genus: Garagaramodoki, Shiogosagoromo Genus: Shiogosagoromo, Iwanokawa Genus: Etsukiiwanokawa, Kainokawa Genus: Kainokawa, Kaninote Genus: Kaninote, Kanonomi, Genus, Sagomo, Dessertica Cyanophora, Sakuranori, Nikumukade, Tambanori, Smooth, Fudarak, Malbahudarak, Isonohana: Nuracusa, Ronulaxa, Giant Coleoptera, Hirakintoki: Hirakintoki, Pleurotus genus: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aimatsumatsu, Fushikintoki, Tsunomukade, Nagakinotoki, Suzumekito, Kakutoitto, Kakutoto Genus Nagaobane: Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Kalexigusa: Kalexigusa, Tosakamokuki: Hosobanotosakamodo, Hirohanotosakamoki, Yatsudegatatosakamoki, Kurotosakanotoka, Japanese moss Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, genus genus: hornworm, lycaenoid genus: lycopodium, cypress, genus genus: nikhonoo, venicenago genus: venicenago, sukakebeni genus: sukakebeni, okamurasa genus: yamadagusa, mirin genus: mirin, saucaminae spp. , Isomocca: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Rhinoceros, Tachiibara, Kagiibaranori, Kizinoo: Kijinoo, Isosanthus: Isodantsuu, Atsubanori: Atsubanori, Ogononori, Ogonotori, Ogonotori, Mizo-Okonori, Kabanori, Beniogonori, Fukuroshinori, Murasaki Kabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogono Li, Sorbus americana, Cyperus sylvestris, Ligustrum serrata, Lily of the valley, Genus sylvestris, L. Genus: crocodile, saimi, crocodile, lotus spp .: lotus spp. Genus genus goats: genus goatsou, hanasakura, fukuronagi genus: fukurotsunagi, sujikonori, hananoeda genus: hananoeda, hiratagoata genus: hiratagoat, darsu : Darus, masagoshibari, anadarus, webagsa genus: webugsa, Benifukuronori: Benifukuronori, Fushitsunagi: Fushitsunagi, Himefushinagi, Hirohafushinagi, Watsunagisou: Hirawagnagisou, Utsuwagisuigi, Iriomota, Iriomota , Genus Egonori: Egonori, Futogigis, Saeda genus: Saeda, Chrysanthemum genus: Chirimomiji, Konohanoriaceae: Habutaenori, Konohanori, Suzurononori, Usveni genus: Usveni, Genus: Hasuziginu, Nagakonosuginonu Genus: Kagiusbanori, Yaleusbanori, Siusiusbanori, Hyusbanori, Usubanorimodoki Genus: Usubanolimodoki, Ayanishiki genus: Ayani Ki, Ayaginu: Ayaginu, Dadia: Enashidazia, Shimadada: Isohagi, Shimadada, Dazimodoki: Dazimomodoki, Itogusa: Moletogusa, Futigusa, Makri: Makuri, Sanaginori: Hanayanagi, Yuna, Yanaginaginamo, Yanaginaginamomori, Yanaginaginomibe, Yanaginaginomibe, and Yanaginaginomibe, Yanaginaginomibe, Yanaginarinamoyana, Yanaginaginoyamo, Yanaginarinamoyana, Yanaginayori, Yanaginayorimo, Yanaginayori, and Yanaginayori-namo-na-yagi-namo-nagi-na-gori , Sasabayanaginori, Sozogenus: Kurosozo, Kobusozo, Hanesozo, Sozonohana, Hanegusa: Hanegusa, Kehanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Genus: Himegoke, Kurohoshigoshi, Hioudoogoshigu Isomegusa, Aspergillus: Aspera, Aspera, Aspera, Aspergillus: Aspera, Aspergillus: Aspergillus, Aspergillus : Kawamozuku, Aokawamozuku, Himekamozuku, Ideyukogome spp .: Ideyukogome, Okichimozuku: Ochichimozuku, Itogusa, Chinorimo: Chinorimo, Chisinori: etc.).
[0052]
Axle algae (Erythra spp., Echinacea spp., Hoshiturimo genus: Hoshiturimo, Lichnotamus genus, Phalaenopsis genus: Himejirabamo, Chaboflavidium, Tripella genus, etc.), yellow algae (Hikarimo genus: Hikarimo etc.) and the like.
[0053]
In addition, as a material derived from animal-based raw materials, a cockscomb extract, a cow or pig, a human placenta extract, a cow or pig stomach, a duodenum, an intestine, an extract of a spleen or a decomposition product thereof, a cow or pig brain tissue Extract, collagen hydrolyzate (acid, alkali, enzyme, etc.) hydrolyzate of bovine / pork or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin or elastin hydrolyzate of bovine / pork / fish (acid, Alkali or enzyme) or water-soluble elastin derivative, keratin and its degradation product or their derivative, silk protein and its degradation product or their derivative, pig or bovine blood cell protein degradation product (globin peptide), cow or pig hemoglobin Decomposition products (hemin, hematin, heme, protohem, heme iron, etc.), milk, casein and its decomposition products or derivatives thereof, skim milk powder and its decomposition products or it Derivatives, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0054]
In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, or the like derived from a genetically modified product or a cell fusion can be used. Furthermore, for example, undifferentiated cells or cells undergoing differentiation, which are obtained by culturing cells at any site, cell, tissue, organ, or the like, can also be used.
[0055]
(14) Marine components
Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salt obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fungo), for example , Italian fango, German fango, Eifelfango, Freiburgfango, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide , Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintokushi, black pearl stone, etc.
[0056]
(15) Microbial culture metabolite
Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red bran, white bran) ) Fermented extract, Euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermentation product of raw milk or skim milk powder, lactic acid fermentation product of leguminous plant, lactic acid fermentation product of coconut genus plant, and the like.
[0057]
(16) α-hydroxy acids
Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0058]
(17) Inorganic pigment
Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0059]
(18) UV absorber / blocker
Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Sodium acid, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.) , Methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, paramethoxycinnamate 2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, etc., salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, Myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives , Dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative , Vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, Talc, kaolin, etc.
[0060]
(19) Whitening agent
Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives , Nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein , Berberine, placenta extract, ellagic acid, lucinol, etc.
[0061]
(20) Tyrosinase activity inhibitor
Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or its derivative, N-acetyltyrosine or its derivative , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, Admiral, bolet, hops, hawthorn, eucalyptus, yarrow, Altea, calyx, mankei, hammeris, caragua or yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, mahuang, senkyu, dokkatsu, psycho, Ufuu, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0062]
(21) Melanin pigment reduction / decomposition substance
Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether) and the like.
[0063]
(22) Turnover promoting action / cell activator
Hydroquinone, lactic acid bacterium extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, ogon, horsetail, gentian, burdock, sicon, carrot, Hamamelis, hops, okinin, edulis, assembly, touki, balsam, amacha, hypericum, cucumber, scotch, mannenrou, parsley) and the like.
[0064]
(23) Astringent
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds) and the like.
[0065]
(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.
[0066]
(25) Antioxidant
Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaseletenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamolin, gossypol, propolis etc.
[0067]
(26) Lipid peroxide production inhibitor
β-carotene, plant extracts (sesame cultured cells, amacha, Hypericum perforatum, hamamelis, clove, melissa, emisoso, birch, salvia, mannenrou, Nantenmi, Eijitsu, Ginkgo, green tea) and the like.
[0068]
(27) Anti-inflammatory agent
Icutamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof Salt, licorice extract, sicon extract, age extract, propolis and the like.
[0069]
(28) Antibacterial, disinfectant, disinfectant
Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine compound, iodoform, sorbin Acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophen, chlorohexidi , Ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether , Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benza chloride) Ruconium, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, Star Le violet, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.
[0070]
(29) Moisturizer
Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative , Pyrrolidonecarboxylic acid or a salt thereof, sodium lactate, urea, sorbitol, amino acid or a derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, Tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates, Acid, nitrate, citrate, or pyrrolidone carboxylic acid), oils and fats such as avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, Cucumber oil, beef tallow fatty acid, quince seed oil, kukuinut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, Peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, coconut oil, eucalyptus oil, tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (hardened) Oil) ", waxes (bee wax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin) , Hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax), natto metabolite, natto extract, silk fiber extract, plant extract (Akamatsu sap, aloe, kakkon, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assemblage, mulberry bark, biwa leaf, loofah, peony, penguin) and the like.
[0071]
(30) Elastase activity inhibitor
Diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, Mulberry leaf, Calyx, Gennoshoko, Comfrey, Salvia, Agaricus japonicus, Bodaiju, Botanpi), seaweed extract and the like.
[0072]
(31) Hair agent
Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0073]
(32) Antiandrogen agent
Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone, etc.
[0074]
(33) Peripheral vascular blood flow promoter
Vitamin E or its derivatives, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.
[0075]
(34) Stimulant
Pepper tincture, nonyl acid vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.
[0076]
(35) Metabolic activator
Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate, and the like.
[0077]
(36) Antiseborrheic
Pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.
[0078]
(37) Keratolytic agent
Resorcinol, salicylic acid, lactic acid, urea, etc.
[0079]
(38) Oxidizing agent
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.
[0080]
(39) Hair remover
Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide and calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0081]
(40) Hair swelling agent
Ethanolamine, urea, guanidine, etc.
[0082]
(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol P-nitroorthophenylenediamine, p-phenylenediamine, p-methylaminophenol, picramic acid, sodium piclamate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- ( 2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, sulfuric acid Orthochloroparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitrophenol sulfate Tophenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcinol , Tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.
[0083]
(42) Fragrance
Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black character Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, large fragrance essential oil, Tuberose essential oil, T-shaped essential oil, orange flower essential oil, winter green essential oil, Truval sam essential oil, baturi essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil, sandalwood essential oil, petitgren essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, perl Vegetable flavors such as balsam essential oil, boad rose essential oil, camphor essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannen wax) essential oil, Japanese mint essential oil, etc. Synthetic fragrances, etc.
[0084]
(43) Dyes / colorants
Red cabbage pigment, red rice pigment, Akane pigment, anato pigment, squid pigment, turmeric pigment, endju pigment, krill pigment, persimmon pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, Buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.
[0085]
(44) Other
Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / antibiotics, cooling agents, stabilizers, emulsifiers, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products , Animal and plant glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters) Etc.), oral agents, deodorants / deodorants, bittering agents, seasonings, etc., are expected to be added or synergistically improved in the effects of the present invention or other cosmetic effects when used in combination therewith. it can.
[0086]
In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, cooling agents, stabilizers, emulsifiers, animal / vegetable proteins and their degradation products, animal / vegetable Saccharides and their degradation products, animal and plant glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents / antiallergic agents, cell activators, keratolytic agents, wound treatment agents, foaming agents, thickening agents, oral cavity Ingredients, deodorants / deodorants, bitters, seasonings, enzymes, etc. are used, and when used in combination therewith, various additive and synergistic effects can be expected.
[0087]
Further, the dosage form and form of the humectant, immunosuppressant, and external preparation for skin of the present invention are arbitrary, and include capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets and the like. Can be used in combination.
[0088]
The field of use can be used, for example, in various external preparations (including preparations used for animals) in general, and specifically, ampules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) quasi-drugs, 3) Topical or systemic skin cosmetics (eg, lotions, emulsions) in suitable forms for use such as air bubbles, emulsions, sheets, mist, sprays, etc. , Creams, ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, depilatory agents, shaving treatments, after-shave lotions, pre-show lotions, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfume, nail polish, nail enamel, nail Namel removers, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.) 4) Medicinal or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, Hair treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair tonic agents, hair restoration / hair restoration, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.) 5) Bath Bath agents used in hot water; 6) Others include axillary deodorants, deodorants, deodorants, antiperspirants, sanitary products, sanitary cotton, wet tissues, toothpastes, mouth fresheners, gargles, etc. Can be
[0089]
The moisturizing agent of the present invention, the method for preventing immunity lowering, and the method for adding to the external preparation for skin may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability. .
[0090]
【Example】
Hereinafter, production examples, test examples, and prescription examples will be described, but the present invention is not limited thereto.
[0091]
(Production Example 1)
100 g of each of Pleurotus ostreatus, Kawatake mushroom, Kofukisaronokoshika, Kanaanatake, Yamadoritake, Matsutake, Truffle, and Mesimakobu are each extracted by heating with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solids: about 0). .1 to 2.5%).
[0092]
(Production Example 2)
100 g of Ohitake mushroom, Kawaratake mushroom, Kofukisaronokoshikam, Kanaanatake mushroom, Yamadoritake mushroom, Matsutake mushroom, Truffle, Mesimakobu mushroom are each 30% ethanol solution or 30% 1,3-butylene glycol solution, or 30% propylene glycol solution, or purified water (about 30 ° C). ), Extract at room temperature for 5 days and nights, and filter to obtain about 1.0 kg of extract (dry solids: about 0.1 to 2.5%).
[0093]
(Production Example 3)
50 g each of Shimeji mushroom and Enokitake mushroom, and 50 g each of Ohitake mushroom, Kawaratake mushroom, Kofukisaronokoshake, Kanaanatake mushroom, Yamadritake mushroom, Matsutake mushroom, Truffle and Mesimakobu were heated and extracted with purified water (about 80 ° C) for about 5 hours, filtered and extracted. About 1.5 kg of liquid (dry solids: about 0.1-2.5%) is obtained.
[0094]
(Production Example 4)
50 g each of Shimeji mushroom and Enokitake mushroom, and 50 g each of Ohitake mushroom, Kawaratake mushroom, Kofukisaronokoshake, Kanaanatake mushroom, Yamatori mushroom, Matsutake mushroom, Truffle, Mesimakobu mushroom, 30% ethanol solution or 30% 1,3-butylene glycol solution, or 30% propylene glycol solution Or, it is immersed in purified water (about 30 ° C.), extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.5 kg of an extract (dry solid content: about 0.1 to 2.5%).
[0095]
(Test 1) Moisturizing test
(Test method)
a. sample
The extract obtained in Production Example 1 and Production Example 3 of the present invention, which had been adjusted to a solid concentration of 1.0%, was subjected to a test. Purified water was used as a control.
b. Test method
The electrical conductivity of the skin was measured with an electrode having an outer diameter of 6 mm and a center diameter of 1 mm using an epidermis horny layer moisture content measuring device (high frequency IMPERDANCE METER model IB 335, manufactured by IBS Co., Ltd.). The measurement site is the inside of the forearm flexion side, and the electrical conductivity of the measurement site is measured in advance. Next, about 1 mL of each sample was applied to the measurement site, an excess sample was removed 30 seconds later, the electric conductivity was measured 5 minutes later, and a moisture retention test was performed. The results are shown in Table 1.
c. Test condition
Temperature: 22-24 ° C, relative humidity: 50-52%
[0096]
[Table 1]

[0097]
(Test results)
As shown in Table 1, it was confirmed that the various extracts of Pleurotus ostreatus, Kawatake mushroom, Kofukisaronoshikake, Kabaanatake, Yamadoritake, Matsutake, Truffle and Meshimakobu of the present invention have higher electric conductivity than purified water and have an excellent moisturizing effect. Was done.
Furthermore, the combined use of the Shimeji and Enokitake mushroom extracts and the above-mentioned various extracts confirmed a more excellent moisturizing effect.
[0098]
(Test 2) Prevention test of immunological decline induced by ultraviolet rays
It has recently been known that the ultraviolet (UV-B) reduces the immune function of the skin, and these phenomena are caused by Langerhans cells (hereinafter referred to as LC cells) in the cells constituting the skin. , UV-B irradiation is considered to be caused by disappearance or deterioration of function. LC cells have a function of transmitting antigen or cancer cell information to immune cells (T cells), and are considered to be deeply involved in the contact hypersensitivity reaction (Ueda, 9th SCCJ Seminar text 10 (1996)). In this study, in order to examine the effect of preventing skin from decreasing immunity, a protective effect on the reduction of contact hypersensitivity reaction induced by ultraviolet rays (Horio et al .: Nisshinkai 105 (12), 1621 (1995), Uchida: Fragrance Journal 9, 29 (1991)) was measured and examined using the contact hypersensitivity reaction as an index.
[0099]
(Test method)
a. sample
The extract obtained in Production Examples 1 and 3 of the present invention was concentrated under reduced pressure by evaporating the solvent under reduced pressure, and then a hydrophilic petrolatum ointment containing 5.0% in terms of solid content was prepared. Manufactured and used by conventional methods.
b. Measurement of edema swelling rate
That is, 50 mJ / cm of ultraviolet rays (using a FL-20SE lamp manufactured by Toshiba as UV-B lamp) was applied to the back of the mouse whose hair had been removed with an electric clipper and an electric shaver three days ago. ² Irradiated. Immediately thereafter, the test drug was applied to the irradiated site, and the same was applied the next day and the next two days, and the test was performed a total of three times. Six hours after the final application, 25 μL of 0.2% (W / W) DNFB solution (1-Fluoro-2,4-dinitrobenzene, Wako Pure Chemical, dissolved in acetone: olive oil 4: 1) was applied to the back of the mouse. Coated and sensitized. 7 days after sensitization, 20% of 0.2% DNFB was applied to the auricle of one side of the mouse. In the evaluation method, the left and right auricles were cut out with a punch (about 5 mm in diameter) 24 hours after ripening, the weight of the cut out auricles was measured, and the difference was defined as the auricle swelling value. In addition, the animals which were not subjected to the ultraviolet irradiation and the test drug and were subjected to only the sensitizing operation (unirradiated group) were provided for comparison. In addition, eight 10-week-old C3H / HeN female mice were used per group. Table 2 shows the edema swelling ratio of each sample.
[0100]
[Table 2]

[0101]
(Test results)
As a result of observing the inflammation of the contact hypersensitivity reaction caused by the DNFB solution performed in this test method, the edema swelling rate was higher in the group irradiated with ultraviolet rays (control) than in the group not irradiated with ultraviolet rays (unirradiated). A tendency to decrease the swelling rate (decreased skin immune response) was observed. However, in the group to which the various extracts of Ohitake mushroom, Kawatake mushroom, Kofukisaronokoshika, Kanaanatake, Yamadoritake, Matsutake, Truffle and Meshimakobu of the present invention were applied after irradiation with ultraviolet rays, the reduction of the edema swelling rate was suppressed at all. From these results, it was confirmed that the extracts of Ohitake mushroom, Kawatake mushroom, Kofukisaronokoshikatake, Kanaanatake, Yamadoritake, Matsutake, Truffle, and Meshimakobu of the present invention have a preventive effect against a decrease in an immune reaction caused by ultraviolet rays.
Furthermore, the combined use of the Shimeji mushroom and Enokitake mushroom extracts and the above-mentioned various extracts confirmed a more excellent immunosuppressive preventive action.
[0102]
In addition, the immunosuppression of the skin is related to the damage of LC cells, which secrete EGF (epidermal growth factor) and FGF (fibroblast growth factor) and are indispensable for maintaining the skin structure. Thus, it can be suggested that the product of the present invention is important for maintaining the skin structure. In addition, since the product of the present invention enhances skin immunity by maintaining LC cells normally, it can be expected to have an effect on skin cancer and pigmentation caused by reduced immunity.
[0103]
(Test 3) Safety test
(1) Skin primary irritation test
Japanese white rabbits (female, group 3) were prepared by preparing the product of the present invention obtained in Production Examples 1 to 4 with purified water so as to have a dry solid concentration of about 1.0 W / V%, and shaving the back. (Approximately 2.3 kg body weight per animal). Judgment was made 24, 48, and 72 hours after application by primary irritation scoring using erythema and edema as indices. The result was negative in all animals without any erythema and edema.
[0104]
(Test 4) Safety test
(2) Skin irritation test
Similarly, the product of the present invention obtained in Production Examples 1 to 4 was prepared with purified water so as to have a dry solid content of about 1.0 W / V%, and a Hartley guinea pig (female, 1 0.5 mL / animal was applied once a day, 5 times a week to the skin of a group of 3 animals, weighing about 320 g). Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day following each application day and the day after the last application day by using the primary irritancy scoring method as an index of erythema and edema. The results were negative for all animals without any erythema and edema over 2 weeks.
[0105]
(Test 5) Safety test
(3) Acute toxicity test
Similarly, a ddy mouse (powder obtained by fasting for 4 hours before the test with a powder (dry solid content: about 1.0 W / V%) obtained by concentrating and drying the product of the present invention obtained in Production Examples 1 to 4 under reduced pressure was used. Male and female, 5 animals per group, 5 weeks old) were orally administered at a dose of 2,000 mg / kg, and the appearance and degree of toxicity symptoms were observed over time. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, LD50 was determined to be 2,000 mg / kg or more.
[0106]
(Prescription examples) Manufacture of various moisturizers, immunosuppressants, and external preparations for skin
In accordance with the above evaluation results, formulation examples are shown below, and the formulation examples may be those manufactured by a usual method in the manufacture of each product, and only the compounding amounts are shown. Further, the present invention is not limited to these.
[0107]

[0108]

[0109]

[0110]

[0111]

[0112]

[0113]

[0114]

[0115]

[0116]

[0117]

[0118]

[0119]

[0120]

[0121]

[0122]

[0123]

[0124]

[0125]

[0126]

[0127]

[0128]

[0129]

[0130]

[0131]

[0132]

[0133]

[0134]

[0135]
(Formulation Example 29) Coating protective agent
A gauze or liniment cloth is impregnated with a prescription solution prepared by mixing an appropriate amount of shimeji, enokitake, kawatake mushroom hot water extract, antibiotics, anti-inflammatory agents, etc., and attaches it to the wound. Alternatively, these may be directly sprayed locally and covered with gauze or the like.
[0136]
(Test 6) Use effect test
The effect when the skin external preparation and bath agent of the present invention were actually used was examined. The use test was conducted by a panel of 10 people aged 30 to 60 who were worried about skin with no shiny or firm skin, and applied the appropriate amount of the emulsion of Formulation Example 1 to the face twice a day, morning and night, and after washing the face for 3 months. It was performed by coating.
[0137]
Furthermore, as for the bath preparation of Prescription Example 28, an appropriate amount of bath preparation was always dissolved once a day for 10 months for 10 persons aged 30 to 60 who were worried about skin without gloss and tension. We had you take a bath and performed use test. As a control, an emulsion or a bath preparation prepared by removing the plant extract of the present invention from the bath preparation by the same method was used. The evaluation was performed according to the following criteria. The results are as shown in Tables 3 and 4, and the numbers in the table represent the number of persons. No one complained of skin abnormalities during the use period.
[0138]
"Skin feel improvement effect"
Effective: Skin gloss / tension increased and skin improved.
Slightly effective: The gloss and tension of the skin increased slightly, and the skin was improved.
Ineffective: No change from before use.
[0139]
[Table 3]

[0140]
[Table 4]

[0141]
(Test results)
From Tables 3 and 4, it can be seen that the extracts of Ohitake mushroom, Kawatake mushroom, Kofukisaronokoshikatake, Kanaanatake, Yamadoritake, Matsutake, Truffle and Meshimakobu of the present invention significantly improve rough and dry skin, and also provide gloss and tension to skin. It was confirmed to give.
[0142]
【The invention's effect】
One or more extracts selected from Pleurotus ostreatus, Kawatake mushroom, Kofukisaronokoshitake, Kabaanatake, Yamadoritake, Matsutake, Truffle, and Mesimakobu of the present invention have a moisturizing action and an immunosuppressive action. Further, the combined use of Shimeji mushroom and Enokitake mushroom extract exerts a more excellent effect, and these are safe even when used internally or externally for humans or animals.
Therefore, it can be applied as a moisturizing agent, a preventive agent for lowering immunity or an external preparation for skin, and can also be used for preventing and improving rough and dry skin, or for giving gloss and tension to the skin, and for preventing skin aging. . In addition, since the product of the present invention enhances skin immunity due to its effect of maintaining LC cells normally, it can be expected to have an effect on skin cancer and pigmentation caused by decreased immunity.

Claims (5)

A moisturizing agent comprising an extract obtained from one or more selected from Pleurotus ostreatus, Kawatake mushroom, Kofukisaronoshikake, Kanaanatake, Yamadoritake, Matsutake, Truffle, and Mesimakobu. An immunosuppressive agent comprising an extract obtained from one or more selected from Oyster mushroom, Kawatake mushroom, Kofukisaronokoshake, Kanaanatake mushroom, Yamadoritake mushroom, Matsutake mushroom, Truffle, Mesimakobu mushroom. A humectant comprising the following (A) and (B) as essential components:
(A) an extract obtained from one or two or more selected from Pleurotus ostreatus, Kawatake mushroom, Kofukisaronokoshikame, Kabaanatake, Yamadoritake, Matsutake, Truffle, Mesimakobu,
(B) Extract obtained from Shimeji and Enokitake An agent for preventing immunity, comprising the following (A) and (B) as essential components:
(A) an extract obtained from one or two or more selected from Pleurotus ostreatus, Kawatake mushroom, Kofukisaronokoshikame, Kabaanatake, Yamadoritake, Matsutake, Truffle, Mesimakobu,
(B) Extract obtained from Shimeji and Enokitake An external preparation for skin, comprising the moisturizing agent or the immunosuppressant according to any one of claims 1 to 4.